@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr2045: (2018-01-25 )
MEANMKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSANRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISSEKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLINIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVIVRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80......--------..-90........100.......110.......120.......130-----------....-...140-........150.......160...--.--.-..170.......180.......190.-......--200.......210........220.......230.......240.......250......-.260........270.......280.......290-.......300--.........-----310.....------.----..320.......330....-.-.----..340---------.........350......----------.360.......370.....-..380.......390.....--------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEA
N
M
K
H
L
K
T
F
Y
K
K
W
F
Q
L
L
V
V
I
V
I
S
F
F
SGALGS
F
S
I
T
Q
L
TQKSSVNNSNNN
S
T
I
T
Q
T
A
YKNEN
S
T
T
Q
A
V
N
K
V
K
D
A
V
V
S
V
I
T
YSANRQ--------NS-VFGNDDTDT
D
S
Q
RISSEG
S
G
V
I
Y
K
KND
K
E
A
Y
I
V
TN
N
H
V
INGA
S
-----------
K
V
D
I
-
R
LSDG--TKVPG
E
I
VGADTFS
D
I
A
V
V
K
ISSE--K--
V
-
T
T
V
AEFGDSS
K
L
T
VG
E
T
A
I
A
IGSP
L
G
-
S
E
Y
A
N
T
--
V
T
Q
G
I
V
S
S
LNRN-
V
S
LKSEDG
Q
A
I
S
T
K
A
IQTDTAINPGNSGG
P
L
I
N
IQ
G
Q
V
I
G
I
TS
S
K
I
A-TNG-GTSVEG
L
G
F
AIPA
N
D
A
I
N
I
I
E
Q
L
E
KNGKVTR-PAL
G
I
Q
M
V
----NLSNVSTS
D
-----
I
-
R
RLNIP------S----NVT
S
G
V
I
V
R
S
V
Q
SN-MPAN-G-H----
L
E
K
-----------
Y
D
V
I
T
KVD
D
K
E
IAS
S
T
D
L
----------
Q
S
A
L
YNHSIG
D
T
I
K
I
T
Y
Y
R-NGKEE
T
T
S
I
K
L
NKSSGDLES--------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
82.09
35%
-
- C- -
-
3PV2
-
?
A:
[6-439]
-------------------------------------------------------------
M
P
S
M
A
P
V
L
K
N
I
M
P
A
I
V
N
V
A
V
Q
G
Y
L
P
N
----------------------
R
K
F
E
S
I
G
S
G
V
I
I
D
P
N
N
--
G
V
I
I
T
N
D
H
V
I
R
N
A
S
-----------
L
I
T
V
-
T
L
Q
D
G
--
R
R
L
K
A
R
L
I
G
G
D
S
E
T
D
L
A
V
L
K
I
D
A
K
--
N
--
L
-
K
S
L
-
V
I
G
D
S
D
K
L
E
V
G
D
F
V
V
A
I
G
N
P
F
G
---
L
S
Q
S
--
A
T
F
G
I
V
S
A
L
K
N
F
----------------
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
A
L
V
N
A
K
G
E
L
I
G
I
N
T
A
I
L
V
----------
G
I
G
F
A
I
P
I
N
M
V
K
D
V
A
Q
Q
I
I
K
F
G
S
I
H
R
-
G
L
M
G
I
F
V
Q
----
H
L
T
---
P
E
L
-----
A
-
Q
A
M
G
Y
P
------
E
----
D
-
F
Q
G
A
L
V
S
Q
V
N
P
N
-
S
P
A
E
-
L
A
G
----
L
K
A
-----------
G
D
I
I
T
Q
I
N
D
T
K
I
T
Q
A
T
Q
V
----------
K
T
T
I
S
L
L
R
V
G
S
T
V
K
I
I
V
E
R
-
D
N
K
P
L
T
L
S
A
V
V
T
D
I
K
S
H
E
Q
K
L
Q
S
N
N
PFLYG
L
A
L
R
A
F
E
Q
ESPPH
G
N
V
I
G
V
Q
VVGASENS
A
G
W
R
A
GIRPG
D
I
I
ISANKKPVTD
V
K
S
L
Q
T
I
A
Q
EKKK
E
L
L
V
Q
V
L
R
GP
G
S
M
Y
L
L
V
I------------------------------------------------------
79
HHSearch
75.16
36%
-29
- C1 -
-
5T69
-
HHOA_SYNY3
A:
[27-361]
------------------------------------------------------------
S
E
S
F
V
A
A
A
V
S
R
S
G
P
A
V
V
R
I
D
T
E
--------------------------------
Q
G
S
G
F
I
I
D
N
---
S
G
I
I
L
T
N
A
H
V
V
D
G
A
S
-----------
K
V
V
V
-
T
L
R
D
G
--
R
T
F
D
G
Q
V
R
G
T
D
E
V
T
D
L
A
V
V
K
I
E
P
Q
G
S
A
--
L
--
P
V
A
P
L
G
T
S
S
N
L
Q
V
G
D
W
A
I
A
V
G
N
P
V
G
-
L
--
D
N
T
--
V
T
L
G
I
I
S
T
L
G
---------------
V
E
F
I
Q
T
D
A
A
I
N
P
G
N
A
G
G
P
L
L
N
A
R
G
E
V
I
G
I
N
T
A
I
-----------
T
G
I
G
F
A
I
P
I
D
Q
A
K
A
I
Q
N
T
L
A
A
G
G
T
V
P
H
-
P
Y
I
G
V
Q
M
M
----
N
I
T
V
D
Q
A
---------
Q
Q
N
N
R
N
PNSPFI
I
----
P
E
V
D
G
I
L
V
M
R
V
L
P
G
-
T
P
A
E
R
A
-
G
----
I
R
R
-----------
G
D
V
I
V
A
V
D
G
T
P
I
S
D
G
A
R
L
----------
Q
R
I
V
E
Q
A
G
L
N
K
A
L
K
L
D
L
L
R
---
R
R
L
S
L
T
V
Q
T
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
72.81
30%
-13
- C1 -
-
1TE0
-
DEGS_ECOLI
A:
[43-352]
------------------------------------------------------------
T
P
A
S
Y
N
L
A
V
R
R
A
A
P
A
V
V
N
V
Y
N
R
G
L
N
T
N
------------
S
H
------
N
Q
L
E
I
R
T
L
G
S
G
V
I
M
D
Q
---
R
G
Y
I
I
T
N
K
H
V
I
N
D
A
D
-----------
Q
I
I
V
-
A
L
Q
D
G
--
R
V
F
E
A
L
L
V
G
S
D
S
L
T
D
L
A
V
L
I
I
K
A
T
G-
G
--
L
--
P
T
I
P
I
N
A
R
R
V
P
H
I
G
D
V
V
L
A
I
G
N
P
Y
N
-
L
--
G
Q
T
--
I
T
Q
G
I
I
S
A
T
G
R
I
-
G
L
N
P
T
-----
G
R
Q
N
F
L
Q
T
D
A
S
I
N
H
G
N
S
G
G
A
L
V
N
S
L
G
E
L
M
G
I
N
T
L
S
F
D
-
K
S
N
D
G
E
T
P
E
G
I
G
F
A
I
P
F
Q
L
A
T
K
I
M
D
K
L
I
R
D
G
R
V
I
R
-
G
Y
I
G
I
G
G
R
----
E
I
A
P
L
H
--------
A
-
Q
G
G
G
I
D
------------
Q
L
Q
G
I
V
V
N
E
V
S
P
D
-
G
P
A
A
N
A
-
G
----
I
Q
V
-----------
N
D
L
I
I
S
V
D
N
K
P
A
I
S
A
L
E
T
----------
M
D
Q
V
A
E
I
R
P
G
S
V
I
P
V
V
V
M
R
-
D
D
K
Q
L
T
L
Q
V
T
I
Q
E
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
72.11
33%
-
- C1 -
-
4IC6
-
DEGP8_ARATH
A:
[112-447]
---------------------------------------------------------
L
F
P
T
E
G
R
I
V
Q
L
F
E
K
N
T
Y
S
V
V
N
I
F
D
V
T
L
R
P
---------------------------
G
N
G
S
G
V
V
W
D
G
---
Q
G
Y
I
V
T
N
Y
H
V
I
G
N
A
L
S
R
NPSPGDVV
G
R
V
N
I
-
L
A
S
D
G
V
Q
K
N
F
E
G
K
L
V
G
A
D
R
A
K
D
L
A
V
L
K
V
D
A
P
--
E
TL
L
--
K
P
I
K
V
G
Q
S
N
S
L
K
V
G
Q
Q
C
L
A
I
G
N
P
F
G
-
F
--
D
H
T
--
L
T
V
G
V
I
S
G
L
N
R
D
-
I
F
S
Q
T
G
---
V
T
I
G
G
G
I
Q
T
D
A
A
I
N
P
G
N
A
G
G
P
L
L
D
S
K
G
N
L
I
G
I
N
T
A
I
F
T
-
Q
T
---
G
T
S
A
G
V
G
F
A
I
P
S
S
T
V
L
K
I
V
P
Q
L
I
Q
F
S
K
V
L
R
-
A
G
I
N
I
E
L
A
----
P
D
P
V
----------
A
-
N
Q
L
N
V
--------------
R
N
G
A
L
V
L
Q
V
P
G
K
-
S
L
A
E
K
A
-
G
----
L
H
P
T
S
R
G
FAGNIVL
G
D
I
I
V
A
V
D
D
K
P
V
K
N
K
A
E
L
----------
M
K
I
L
D
E
Y
S
V
G
D
K
V
T
L
K
I
K
R
-
G
N
E
D
L
E
L
K
I
S
L
E
E
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
71.67
33%
-67
- C1 -
-
3LGI
-
DEGS_ECOLI
B:
[4-231]
----------------------------------------------
L
N
P
L
S
T
P
Q
F
D
S
T
D
E
T
P
A
S
Y
N
L
A
V
R
R
A
A
P
A
V
V
N
V
Y
N
R
G
L
N
T
N
--------
S
----------
H
N
Q
L
E
I
R
T
L
G
S
G
V
I
M
D
Q
R
G
---
Y
I
I
T
N
K
H
V
I
N
D
A
D
-----------
Q
I
I
V
-
A
L
Q
D
G
--
R
V
F
E
A
L
L
V
G
S
D
S
L
T
D
L
A
V
L
K
I
N
A
T
--
G
--
G
-
L
P
T
I
P
I
N
A
R
R
V
P
H
I
G
D
V
V
L
A
I
G
N
P
Y
N
-
L
G
--
Q
T
--
I
T
Q
G
I
I
S
A
T
G
R
------
I
G
L
N
P
T
G
R
Q
N
F
L
Q
T
D
A
S
I
N
H
G
N
S
G
G
A
L
V
N
S
L
G
E
L
M
G
I
N
T
L
S
F
D
K
S
N
D
-
G
E
T
P
E
G
I
G
F
A
I
P
F
Q
L
A
T
K
I
M
D
K
L
I
R
D
G
R
V
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
71.39
36%
-23
- C1 -
-
5B6L
-
HHOA_SYNY3
A:
[3-336]
---------------------------------------------------------------
F
V
A
A
A
V
S
R
S
G
P
A
V
V
R
I
D
---------------------------------
G
Q
G
S
G
F
I
I
D
N
---
S
G
I
I
L
T
N
A
H
V
V
D
G
A
S
------------
V
V
V
-
T
L
R
D
G
--
R
T
F
D
G
Q
V
R
G
T
D
E
V
T
D
L
A
V
V
K
I
E
P
Q
GS
A
--
L
--
P
V
A
P
L
G
T
S
S
N
L
Q
V
G
D
W
A
I
A
V
G
N
P
V
G
-
L
--
D
N
T
--
V
T
L
G
I
I
S
T
L
G
---------------
V
E
F
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
P
L
L
N
A
R
G
E
V
I
G
I
N
T
A
I
------------
G
I
G
F
A
I
P
I
D
Q
A
K
A
I
Q
N
T
L
A
A
G
G
T
V
P
H
-
P
Y
I
G
V
Q
M
M
----
N
I
T
V
D
Q
A
Q
Q
N
N
R
NP
N
-
S
P
F
I
I
P
------
E
------
V
D
G
I
L
V
M
R
V
L
P
G
-
T
P
A
E
R
A
-
G
----
I
R
R
-----------
G
D
V
I
V
A
V
D
G
T
P
I
S
D
G
A
R
L
----------
Q
R
I
V
E
Q
A
G
L
N
K
A
L
K
L
D
L
L
R
-
G
D
R
R
L
S
L
T
V
Q
T
A
Q
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
69.86
25%
-13
- C1 -
-
4FLN
-
DEGP2_ARATH
A:
[42-509]
-------------------------------------------------------------------
H
D
A
S
F
L
N
A
V
V
K
V
Y
C
T
H
T
A
--------------
P
D
Y
S
L
P
W
Q
K
Q
R
Q
F
T
S
T
G
S
A
F
M
I
G
D
G
----
K
L
L
T
N
A
H
C
V
E
H
D
T
-----------
Q
V
K
V
K
R
R
G
D
D
--
R
K
Y
V
A
K
V
L
V
R
G
V
D
C
D
I
A
L
L
S
V
E
S
E
--
D
--
F
W
K
G
A
E
P
L
R
L
G
H
L
P
R
L
Q
D
S
V
T
V
V
G
Y
P
L
G
-
G
D
-
T
I
S
--
V
T
K
G
V
V
S
R
I
E
V
T
-
S
Y
----
A
H
G
S
S
D
L
L
G
I
Q
I
D
A
A
I
N
P
G
N
S
G
G
P
A
F
N
D
Q
G
E
C
I
G
V
A
F
Q
V
Y
----------
E
N
I
G
Y
V
I
P
T
T
V
V
S
H
F
L
T
D
Y
E
R
N
G
K
Y
T
G
Y
P
C
L
G
V
L
L
Q
----
K
L
E
N
P
A
L
R
E
-----
C
-
L
K
V
P
T
N
------
E
--------
G
V
L
V
R
R
V
E
P
T
-
S
D
A
S
-
K
-
V
----
L
K
E
-----------
G
D
V
I
V
S
F
D
D
L
H
V
G
C
E
G
T
V
PFRSS
E
R
I
A
F
R
Y
L
I
S
Q
K
F
A
G
D
I
A
E
I
G
I
I
R
-
A
G
E
H
K
K
V
Q
V
V
L
R
P
R
V
H
L
V
P
Y
HIDG
G
Q
P
S
Y
I
I
VAG
L
V
F
T
P
LS
E
P
L
I
E
EECEDTIG
L
K
L
L
T
K
A
R
YSVARFRGEQIVILSQVLANEVNIGYEDMNN
Q
Q
V
L
K
FNGIPIRN
I
H
H
L
A
H
L
I
D
M
CKDK
Y
L
V
F
E
F
EDNY
V
A
V
L
E
R
E
A
S
N
S
A
S
L
C
I
L
K
D
Y
GIPSERSADLLEPYVD
2
PsiBlast_PDB
68.90
35%
-3
- C1 -
-
3STJ
-
DEGQ_ECOLI
A:
[14-334]
---------------------------------------------------------------
S
L
A
P
M
L
E
K
V
L
P
A
V
V
S
V
R
V
E
G
T
-------------------------
Q
P
F
E
G
L
G
S
G
V
I
I
--
N
A
S
K
G
Y
V
L
T
N
N
H
V
I
N
Q
A
Q
-----------
K
I
S
I
-
Q
L
N
D
G
--
R
E
F
D
A
K
L
I
G
S
D
D
Q
S
D
I
A
L
L
Q
I
Q
N
P
--
S
--
K
-
L
T
Q
I
A
I
A
D
S
D
K
L
R
V
G
D
F
A
V
A
V
G
N
P
F
G
---
L
G
Q
T
--
A
T
S
G
I
V
S
A
L
G
R
S
G
L
N
L
E
G
L
E
------
N
F
I
Q
T
D
A
S
I
N
R
G
N
S
G
G
A
L
L
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
G
G
-
G
S
V
--
G
I
G
F
A
I
P
S
N
M
A
R
T
L
A
Q
Q
L
I
D
F
G
E
I
K
R
-
G
L
L
G
I
K
G
T
----
E
M
S
----
A
D
-----
I
A
K
A
F
N
L
------------
D
V
Q
R
G
A
F
V
S
E
V
----
L
P
G
S
-
G
-
S
A
K
A
G
V
K
A
-----------
G
D
I
I
T
S
L
N
G
K
P
L
N
S
F
A
E
L
----------
R
S
R
I
A
T
T
E
P
G
T
K
V
K
L
G
L
L
R
-
N
G
K
P
L
E
V
E
V
T
L
D
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.17
36%
-38
- C1 -
-
3CS0
-
DEGP_ECOLI
A:
[83-358]
--------------------------------------------------------------------------------------------------------------
K
F
M
A
L
G
S
G
V
I
I
D
A
D
--
K
G
Y
V
V
T
N
N
H
V
V
D
N
A
T
-----------
V
I
K
V
-
Q
L
S
D
G
--
R
K
F
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
I
Q
I
Q
N
P
--
K
--
N
-
L
T
A
I
K
M
A
D
S
D
A
L
R
V
G
D
Y
T
V
A
I
G
N
P
F
G
---
L
G
E
T
--
V
T
S
G
I
V
S
A
L
G
R
S
--
G
L
N
A
E
N
Y
E
N
F
----
I
Q
T
D
A
A
I
N
R
G
N
S
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
D
G
-
G
N
I
--
G
I
G
F
A
I
P
S
N
M
V
K
N
L
T
S
Q
M
V
E
Y
G
Q
V
K
R
-
G
E
L
G
I
M
G
T
----
E
L
-
N
S
E
L
A
K
-----
A
-
M
K
V
--------------
D
A
Q
R
G
A
F
V
S
Q
V
L
P
N
S
S
A
A
K
-
A
-
G
----
I
K
A
-----------
G
D
V
I
T
S
L
N
G
K
P
I
S
S
F
A
A
L
----------
R
A
Q
V
G
T
M
P
V
G
S
K
L
T
L
G
L
L
R
-
D
G
K
Q
V
N
V
N
L
E
L
Q
Q
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.06
35%
-
- C1 -
-
4A8C
-
DEGQ_ECOLI
A:
[14-332]
---------------------------------------------------------------
S
L
A
P
M
L
E
K
V
L
P
A
V
V
S
V
R
V
E
G
T
A
------------------------
Q
P
F
E
G
L
G
S
G
V
I
I
--
N
A
S
K
G
Y
V
L
T
N
N
H
V
I
N
Q
A
Q
-----------
K
I
S
I
-
Q
L
N
D
G
--
R
E
F
D
A
K
L
I
G
S
D
D
Q
S
D
I
A
L
L
Q
I
Q
N
P
--
S
--
K
-
L
T
Q
I
A
I
A
D
S
D
K
L
R
V
G
D
F
A
V
A
V
G
N
P
F
G
---
L
G
Q
T
--
A
T
S
G
I
V
S
A
L
G
R
S
G
L
N
L
E
G
L
E
------
N
F
I
Q
T
D
A
S
I
N
R
G
N
A
G
G
A
L
L
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
G
G
-
G
S
V
--
G
I
G
F
A
I
P
S
N
M
A
R
T
L
A
Q
Q
L
I
D
F
G
E
I
K
R
-
G
L
L
G
I
K
G
T
----
E
M
S
----
A
D
-----
I
A
K
A
F
N
L
------------
D
V
Q
R
G
A
F
V
S
E
V
----
L
P
G
S
-
G
-
S
A
K
A
G
V
K
A
-----------
G
D
I
I
T
S
L
N
G
K
P
L
N
S
F
A
E
L
----------
R
S
R
I
A
T
T
E
P
G
T
K
V
K
L
G
L
L
R
-
N
G
K
P
L
E
V
E
V
T
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.03
36%
-39
- C1 -
-
3MH7
-
DEGP_ECOLI
A:
[83-358]
--------------------------------------------------------------------------------------------------------------
K
F
M
A
L
G
S
G
V
I
I
D
A
D
--
K
G
Y
V
V
T
N
N
H
V
V
D
N
A
T
-----------
V
I
K
V
-
Q
L
S
D
G
--
R
K
F
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
I
Q
I
Q
N
P
--
K
--
N
-
L
T
A
I
K
M
A
D
S
D
A
L
R
V
G
D
Y
T
V
A
I
G
N
P
F
G
---
L
G
E
T
--
V
T
S
G
I
V
S
A
L
G
R
S
--
G
L
N
A
E
N
Y
E
N
F
----
I
Q
T
D
A
A
I
N
R
G
N
A
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
D
G
-
G
N
I
--
G
I
G
F
A
I
P
S
N
M
V
K
N
L
T
S
Q
M
V
E
Y
G
Q
V
K
R
-
G
E
L
G
I
M
G
T
----
E
L
-
N
S
E
L
A
K
-----
A
-
M
K
V
--------------
D
A
Q
R
G
A
F
V
S
Q
V
L
P
N
S
S
A
A
K
-
A
-
G
----
I
K
A
-----------
G
D
V
I
T
S
L
N
G
K
P
I
S
S
F
A
A
L
----------
R
A
Q
V
G
T
M
P
V
G
S
K
L
T
L
G
L
L
R
-
D
G
K
Q
V
N
V
N
L
E
L
Q
Q
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
67.98
34%
-7
- C1 -
-
3QO6
-
DEGP1_ARATH
C:
[17-334]
--------------------------------------------------------------
L
A
T
V
R
L
F
Q
E
N
T
P
S
V
V
Y
I
T
N
L
A
V
R
Q
----------
D
-
A
F
T
----
L
D
V
L
E
V
P
Q
G
S
G
S
G
F
V
W
D
K
---
Q
G
H
I
V
T
N
Y
H
V
I
R
G
A
S
-----------
D
L
R
V
-
T
L
A
D
Q
--
T
T
F
D
A
K
V
V
G
F
D
Q
D
K
D
V
A
V
L
R
I
D
A
P
KN
K
--
L
--
R
P
I
P
V
G
V
S
A
D
L
L
V
G
Q
K
V
F
A
I
G
N
P
F
G
-
L
--
D
H
T
--
L
T
T
G
V
I
S
G
L
R
R
E
-
I
S
S
A
A
T
--
G
R
P
I
Q
D
V
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
P
L
L
D
S
S
G
T
L
I
G
I
N
T
A
I
Y
S
-
P
S
---
G
A
S
S
G
V
G
F
S
I
P
V
D
T
V
G
G
I
V
D
Q
L
V
R
F
G
K
V
T
R
-
P
I
L
G
I
K
F
A
----
P
D
Q
S
V
-----------
E
Q
L
---------------
G
V
S
G
V
L
V
L
D
A
P
P
S
-
G
P
A
G
K
A
-
G
----
L
Q
S
TKRDGYGRLVL
G
D
I
I
T
S
V
N
G
T
K
V
S
N
G
S
D
L
----------
Y
R
I
L
D
Q
C
K
V
G
D
E
V
T
V
E
V
L
R
-
G
D
H
K
E
K
I
S
V
T
L
E
P
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
67.60
35%
-
- C1 -
-
4A8C
-
DEGQ_ECOLI
D:
[11-333]
------------------------------------------------------------
P
L
P
S
L
A
P
M
L
E
K
V
L
P
A
V
V
S
V
R
V
E
G
T
A
------------------------
Q
P
F
E
G
L
G
S
G
V
I
I
N
A
--
S
K
G
Y
V
L
T
N
N
H
V
I
N
Q
A
Q
-----------
K
I
S
I
-
Q
L
N
D
G
--
R
E
F
D
A
K
L
I
G
S
D
D
Q
S
D
I
A
L
L
Q
I
Q
N
P
--
S
--
K
-
L
T
Q
I
A
I
A
D
S
D
K
L
R
V
G
D
F
A
V
A
V
G
N
P
F
G
-
L
--
G
Q
T
--
A
T
S
G
I
V
S
A
L
G
R
S
-
G
L
N
L
E
-----
G
L
E
N
F
I
Q
T
D
A
S
I
N
R
G
N
A
G
G
A
L
L
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
G
---
G
G
S
V
G
I
G
F
A
I
P
S
N
M
A
R
T
L
A
Q
Q
L
I
D
F
G
E
I
K
R
-
G
L
L
G
I
K
G
T
----
E
M
S
A
D
I
--------
A
-
K
A
F
N
L
D
------
V
------
Q
R
G
A
F
V
S
E
V
L
P
G
-
S
G
S
A
K
A
-
G
----
V
K
A
-----------
G
D
I
I
T
S
L
N
G
K
P
L
N
S
F
A
E
L
----------
R
S
R
I
A
T
T
E
P
G
T
K
V
K
L
G
L
L
R
-
N
G
K
P
L
E
V
E
V
T
L
D
T
---------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
67.49
35%
-
- C1 -
-
4A9G
-
DEGQ_ECOLI
A:
[14-332]
---------------------------------------------------------------
S
L
A
P
M
L
E
K
V
L
P
A
V
V
S
V
R
V
E
G
T
A
----------------------------
G
L
G
S
G
V
I
I
--
N
A
S
K
G
Y
V
L
T
N
N
H
V
I
N
Q
A
Q
-----------
K
I
S
I
-
Q
L
N
D
G
--
R
E
F
D
A
K
L
I
G
S
D
D
Q
S
D
I
A
L
L
Q
I
Q
N
P
--
S
--
K
-
L
T
Q
I
A
I
A
D
S
D
K
L
R
V
G
D
F
A
V
A
V
G
N
P
F
G
---
L
G
Q
T
--
A
T
S
G
I
V
S
A
L
G
R
S
G
L
N
L
E
G
L
E
------
N
F
I
Q
T
D
A
S
I
N
R
G
N
A
G
G
A
L
L
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
G
G
-
G
S
V
--
G
I
G
F
A
I
P
S
N
M
A
R
T
L
A
Q
Q
L
I
D
F
G
E
I
K
R
-
G
L
L
G
I
K
G
T
----
E
M
S
----
A
D
-----
I
A
K
A
F
N
L
------------
D
V
Q
R
G
A
F
V
S
E
V
----
L
P
G
S
-
G
-
S
A
K
A
G
V
K
A
-----------
G
D
I
I
T
S
L
N
G
K
P
L
N
S
F
A
E
L
----------
R
S
R
I
A
T
T
E
P
G
T
K
V
K
L
G
L
L
R
-
N
G
K
P
L
E
V
E
V
T
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.32
35%
-9
- C1 -
-
3PV3
-
?
A:
[73-347]
-------------------------------------------------------------------------------------------------------------
R
K
F
E
S
I
G
S
G
V
I
I
D
P
N
N
--
G
V
I
I
T
N
D
H
V
I
R
N
A
S
-----------
L
I
T
V
-
T
L
Q
D
G
--
R
R
L
K
A
R
L
I
G
G
D
S
E
T
D
L
A
V
L
K
I
D
A
K
--
N
--
L
-
K
S
L
V
-
I
G
D
S
D
K
L
E
V
G
D
F
V
V
A
I
G
N
P
F
G
L
N
----
S
Q
S
A
T
F
G
I
V
S
A
L
K
R
S
--
D
------
E
N
F
----
I
Q
T
D
A
A
I
N
P
G
N
A
G
G
A
L
V
N
A
K
G
E
L
I
G
I
N
T
A
I
L
S
-------
V
--
G
I
G
F
A
I
P
I
N
M
V
K
D
V
A
Q
Q
I
I
K
F
G
S
I
H
R
-
G
L
M
G
I
F
V
Q
----
H
L
----
T
P
E
-----
L
A
Q
A
M
G
Y
P
------
E
----
D
F
-
Q
G
A
L
V
S
Q
V
N
P
N
-
S
P
A
E
L
A
-
G
----
L
K
A
-----------
G
D
I
I
T
Q
I
N
D
T
K
I
T
Q
A
T
Q
V
----------
K
T
T
I
S
L
L
R
V
G
S
T
V
K
I
I
V
E
R
-
D
N
K
P
L
T
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.12
36%
-49
- C1 -
-
2ZLE
-
DEGP_ECOLI
A:
[51-313]
-------------------------------------------------------------------------------------------------------------------
G
S
G
V
I
I
D
A
D
--
K
G
Y
V
V
T
N
N
H
V
V
D
N
A
T
-----------
V
I
K
V
-
Q
L
S
D
G
--
R
K
F
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
I
Q
I
Q
N
P
--
K
--
N
-
L
T
A
I
K
M
A
D
S
D
A
L
R
V
G
D
Y
T
V
A
I
G
N
P
F
G
---
L
G
E
T
--
V
T
S
G
I
V
S
A
L
G
R
----------
E
N
F
----
I
Q
T
D
A
A
I
N
R
G
N
S
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
D
G
-
G
N
I
--
G
I
G
F
A
I
P
S
N
M
V
K
N
L
T
S
Q
M
V
E
Y
G
Q
V
K
R
-
G
E
L
G
I
M
G
T
----
E
L
N
S
E
L
A
K
A
-----
M
-
K
-----------
V
----
D
A
Q
R
G
A
F
V
S
Q
V
L
P
N
S
S
A
A
K
-
A
-
G
----
I
K
A
-----------
G
D
V
I
T
S
L
N
G
K
P
I
S
S
F
A
A
L
----------
R
A
Q
V
G
T
M
P
V
G
S
K
L
T
L
G
L
L
R
-
D
G
K
Q
V
N
V
N
L
E
L
Q
Q
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
65.64
35%
28
- C1 -
-
2ZLE
-
DEGP_ECOLI
H:
[2723-3032]
------------------------------------------------------------
Q
M
P
S
L
A
P
M
L
E
K
V
M
P
S
V
V
S
I
N
V
E
G
S
T
T
V
NTPRMPRN
F
Q
Q
F
F
G
-----
G
Q
Q
Q
K
F
M
A
L
G
S
G
V
I
I
D
A
D
--
K
G
Y
V
V
T
N
N
H
V
V
D
N
A
T
-----------
V
I
K
V
-
Q
L
S
D
G
--
R
K
F
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
I
Q
I
Q
N
P
K-
N
--
L
--
T
A
I
K
M
A
D
S
D
A
L
R
V
G
D
Y
T
V
A
I
G
N
P
F
G
-
L
--
G
E
T
--
V
T
S
G
I
V
S
A
L
G
R
--------------
E
N
F
I
Q
T
D
A
A
I
N
R
G
N
S
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
D
---
G
G
N
I
G
I
G
F
A
I
P
S
N
M
V
K
N
L
T
S
Q
M
V
E
Y
G
Q
V
K
R
-
G
E
L
G
I
M
G
T
----
E
L
N
S
E
L
--------
A
-
K
A
M
K
V
D
------------
A
Q
R
G
A
F
V
S
Q
V
L
P
N
-
S
S
A
A
K
A
-
G
----
I
K
A
-----------
G
D
V
I
T
S
L
N
G
K
P
I
S
S
F
A
A
L
----------
R
A
Q
V
G
T
M
P
V
G
S
K
L
T
L
G
L
L
R
-
D
G
K
Q
V
N
V
N
L
E
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
65.62
42%
22
- C1 -
-
2Z9I
-
?
A:
[6-314]
--------------------------------------------------------------
G
S
V
E
Q
V
A
A
K
V
V
P
S
V
V
M
L
E
T
D
L
------------------------------
E
E
G
S
G
I
I
L
S
A
---
E
G
L
I
L
T
N
N
H
V
I
A
A
A
A
KP
P
--------
K
T
T
V
-
T
F
S
D
G
--
R
T
A
P
F
T
V
V
G
A
D
P
T
S
D
I
A
V
V
R
V
Q
G
V
S-
G
--
L
--
T
P
I
S
L
G
S
S
S
D
L
R
V
G
Q
P
V
L
A
I
G
S
P
L
G
-
L
--
E
G
T
--
V
T
T
G
I
V
S
A
L
N
R
P
-
V
S
T
------
N
T
V
L
D
A
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
A
L
V
N
M
N
A
Q
L
V
G
V
N
S
A
I
A
T
-
L
---
Q
S
G
S
I
G
L
G
F
A
I
P
V
D
Q
A
K
R
I
A
D
E
L
I
S
T
G
K
A
S
H
-
A
S
L
G
V
Q
V
T
----
N
D
K
--------------------------------
T
L
G
A
K
I
V
E
V
V
A
G
-
G
A
A
A
N
A
-
G
----
V
P
K
-----------
G
V
V
V
T
K
V
D
D
R
P
I
N
S
A
D
A
L
----------
V
A
A
V
R
S
K
A
P
G
A
T
V
A
L
T
F
Q
D
P
S
G
G
S
R
T
V
Q
V
T
L
G
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
65.56
29%
-19
- C1 -
-
5FHT
1
HTRA2_HUMAN
A:
[12-326]
----------------------------------------------------------
R
S
Q
Y
N
F
I
A
D
V
V
E
K
T
A
P
A
V
V
Y
I
E
I
L
D
R
H
P
-------------
F
L
------
G
R
E
V
P
I
S
N
G
S
G
F
V
V
A
A
---
D
G
L
I
V
T
N
A
H
V
V
A
D
R
R
-----------
R
V
R
V
-
R
L
L
S
G
--
D
T
Y
E
A
V
V
T
A
V
D
P
K
A
D
I
A
T
L
R
I
Q
T
K
E-
P
--
L
--
P
T
L
P
L
G
R
S
A
D
V
R
Q
G
E
F
V
V
A
M
G
S
P
F
A
-
L
--
Q
N
T
--
I
T
S
G
I
V
S
S
A
Q
R
-------
L
--
P
Q
T
N
V
E
Y
I
Q
T
D
A
A
I
D
F
G
N
A
G
G
P
L
V
N
L
D
G
E
V
I
G
V
N
T
M
K
V
T
---------
A
G
I
S
F
A
I
P
S
D
R
L
R
E
F
L
H
R
-------
Q
R
-
R
Y
I
G
V
M
M
L
----
T
L
S
P
S
I
--------
L
-
A
E
L
Q
L
R
------
E
PSFP
D
V
Q
H
G
V
L
I
H
K
V
I
L
G
-
S
P
A
H
R
A
-
G
----
L
R
P
-----------
G
D
V
I
L
A
I
G
E
Q
M
V
Q
N
A
E
D
V
----------
Y
E
A
V
R
---
T
Q
S
Q
L
A
V
Q
I
R
R
-
G
R
E
T
L
T
L
Y
V
T
P
E
V
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.17
36%
-26
- C1 -
-
3OU0
-
DEGP_ECOLI
A:
[83-358]
--------------------------------------------------------------------------------------------------------------
K
F
M
A
L
G
S
G
V
I
I
D
A
D
--
K
G
Y
V
V
T
N
N
H
V
V
D
N
A
T
-----------
V
I
K
V
-
Q
L
S
D
G
--
R
K
F
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
I
Q
I
Q
N
P
--
K
--
N
-
L
T
A
I
K
M
A
D
S
D
A
L
R
V
G
D
Y
T
V
A
I
G
N
P
F
G
---
L
G
E
T
--
V
T
S
G
I
V
S
A
L
G
R
S
--
G
L
N
A
E
N
Y
E
N
F
----
I
Q
T
D
A
A
I
N
R
G
N
A
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
D
G
-
G
N
I
--
G
I
G
F
A
I
P
S
N
M
V
K
N
L
T
S
Q
M
V
E
Y
G
Q
V
K
R
-
G
E
L
G
I
M
G
T
E
LN
S
E
L
A
K
A
M
K
V
D
-----
A
-
Q
R
-------------------
G
A
F
V
S
Q
V
L
P
N
S
S
A
A
K
-
A
-
G
----
I
K
A
-----------
G
D
V
I
T
S
L
N
G
K
P
I
S
S
F
A
A
L
----------
R
A
Q
V
G
T
M
P
V
G
S
K
L
T
L
G
L
L
R
-
D
G
K
Q
V
N
V
N
L
E
L
Q
Q
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
60.94
36%
-36
- C1 -
-
3MH6
1
DEGP_ECOLI
A:
[88-358]
-------------------------------------------------------------------------------------------------------------------
G
S
G
V
I
I
D
A
D
--
K
G
Y
V
V
T
N
N
H
V
V
D
N
A
T
-----------
V
I
K
V
-
Q
L
S
D
G
--
R
K
F
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
I
Q
I
Q
N
P
--
K
--
N
-
L
T
A
I
K
M
A
D
S
D
A
L
R
V
G
D
Y
T
V
A
I
G
N
P
F
G
---
L
G
E
T
--
V
T
S
G
I
V
S
A
L
G
R
S
--
G
L
N
A
E
N
Y
E
N
F
----
I
Q
T
D
A
A
I
N
R
G
N
S
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
-
P
D
G
-
G
N
I
--
G
I
G
F
A
I
P
S
N
M
V
K
N
L
T
S
Q
M
V
E
Y
G
Q
V
K
R
-
G
E
L
G
I
M
G
T
----
E
L
N
S
E
L
A
K
A
-----
M
-
K
-----------
V
----
D
A
Q
R
G
A
F
V
S
Q
V
L
P
N
S
S
A
A
K
-
A
-
G
----
I
K
A
-----------
G
D
V
I
T
S
L
N
G
K
P
I
S
S
F
A
A
L
----------
R
A
Q
V
G
T
M
P
V
G
S
K
L
T
L
G
L
L
R
-
D
G
K
Q
V
N
V
N
L
E
L
Q
Q
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
49.70
38%
-66
- C1 -
-
3TJO
5
HTRA1_HUMAN
B:
[63-219]
-----------------------------------------------------------------------------------------------------------------
A
S
G
S
G
F
I
V
---
S
E
D
G
L
I
V
T
N
A
H
V
V
T
N
K
H
-----------
R
V
K
V
-
E
L
K
N
G
--
A
T
Y
E
A
K
I
K
D
V
D
E
K
A
D
I
A
L
I
K
I
D
H
Q
--
G
--
K
-
L
P
V
L
L
L
G
R
S
S
E
L
R
P
G
E
F
V
V
A
I
G
S
P
F
S
-
L
Q
--
N
T
--
V
T
T
G
I
V
S
T
T
Q
----------------
D
Y
I
Q
T
D
A
I
I
N
Y
G
N
A
G
G
P
L
V
N
L
D
G
E
V
I
G
I
N
T
L
K
V
T
-
A
--------
G
I
S
F
A
I
P
S
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------