@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VK98: (2017-10-25 )
MLHFTFLGTSSGVPTLSRNVSGLAVRNSKNKDWILVDAGEGTQHRIQQARLSLQNLIAICITHVHGDHCYGLVGLLASAGMNARNNPLIVIAPKEIQQWFEITAQLTDLHLPYSIKFIDVNEATRPQQLTDELFIQAHPLSHRVPSFAFSIYIKSTQKKIDIQALTQLGIPKGDIWGHLKRGYDVEFEGRILKSQDFIKIQNQQIHAIIGGDNDRPELLADACKDAQLLIHEATYLQTVLDKVGKGPMHSSAKMVAEFAEQQSLDNLILTHFSPRHQDKTGQQAIIEEVRQFYKGHFYLANDFDEFTLNETGQLLKIE
Atome Classification :
(20 SA)
----...-.-.....10..--..--------------------.------------------...20.--.---...----...---30.-........40....---...-------.50------------------------------------------------------.........60........70------.........80--.----...----....90........100..-....--.-----110-.--......-..120.......--..-130--....--.....140.----------------.-------------.--------...-.150--------.......160.......170.....------..180......-.190.......200.......210--.-....-----..-----220.-----.--.....230..-.....240-------........-----250--....-.---...260---------.....---------...270.......280.......290-----..-.-....300.......310......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----
M
L
H
-
F
-
T
F
LGTSSGV--P
T
--------------------
L
------------------SRNV
S
G
--
L
---
A
V
R----NSK---N-K-
D
W
I
L
V
DAGE
G
T
Q
H
R
---
I
Q
Q
-------
A
R
-------------------------------------------------------
L
S
L
Q
N
L
I
A
I
C
I
THVHG
D
H
C
Y
-------
G
L
V
G
L
L
A
SAGM--N----ARN----N
P
L
I
V
I
A
P
K
E
I
Q
Q
W
F
E
I
T
A
-
Q
L
TD--L-----H---L--
P
Y
S
I
K
F
-
I
DV--NEAT
R
P
Q
--
Q
L
-
T
----
D
E
L
F
--
I
QAHPLSHR----------------V-------------P--------S
F
A
-
F
S
I
Y
--------
I
KSTQK
K
I
D
I
Q
A
L
T
Q
LGIP
K
G
D
I
W
G
------
H
LKRGY
D
V
E
FE-
G
R
I
LKSQ
D
F
I
K
I
QN
Q
Q
I
H
A
I
IGGD--N-D
R
P
E
-----
L
L
-----
A
D
A
C
-----
K
--
D
A
Q
L
L
I
H
E
A
T
-
Y
L
Q
T
V
L
D
--------KVGKGPM
H
-----
S
-
S
--
A
K
M
V
-
A
---
E
F
A
E
Q
----------
Q
S
L
D
N
---------
L
I
L
THFSPRHQDKTG
Q
Q
A
I
I
E
E
V
R
Q
F
-----YK-G-
H
F
Y
L
ANDFDEFTLNETG
Q
L
L
KIE
23
HHSearch
80.32
30%
-13
- C1 -
-
2CBN
-
RBN_ECOLI
A:
[1-306]
----
A
M
N
-
L
-
I
F
L
G
T
S
A
G
V
--
P
T
--------------------
R
------------------
T
R
N
V
T
A
--
I
---
L
L
N
----
L
Q
H
PT-
Q
-
S
-
G
L
W
L
F
D
C
G
E
G
T
Q
H
Q
---
L
L
H
-------
T
A
-------------------------------------------------------
F
N
P
G
K
L
D
K
I
F
I
S
H
L
H
G
D
H
L
F
-------
G
L
P
G
L
L
C
S
R
S
M
--
S
----
G
I
I
----
Q
P
L
T
I
Y
G
P
Q
G
I
R
E
F
V
E
T
A
L
-
R
I
S
G
--
S
-----
W
---
T
--
D
Y
P
L
E
I
-
V
E
I
--
G
A
-
G
-
E
I
--
L
D
-
D
----
G
L
R
K
--
V
T
A
Y
P
L
E
H
P
----------------
L
-------------
E
--------
C
Y
G
-
Y
R
I
E
--------
E
H
D
A
P
G
A
L
N
A
Q
A
L
K
A
A
G
V
P
P
G
P
L
F
Q
------
E
L
K
A
G
K
T
I
T
L
E
D
G
R
Q
I
N
G
A
D
Y
L
A
A
P
V
P
G
K
A
L
A
I
F
G
D
--
T
-
G
P
C
D
-----
A
A
-----
L
D
L
A
-----
K
--
G
V
D
V
M
V
H
E
A
T
-
L
D
I
T
M
E
A
--------
K
A
N
S
-
R
G
H
-----
S
-
S
--
T
R
Q
A
-
A
---
T
L
A
R
E
----------
A
G
V
G
K
---------
L
I
I
T
H
V
S
S
R
Y
D
D
K
G
C
-
Q
H
L
L
R
E
C
R
S
I
-----
F
P
---
A
T
E
L
A
N
D
F
T
V
F
N
V
----------
1
PsiBlast_PDB
79.94
30%
-2
- C1 -
-
2CBN
-
RBN_ECOLI
A:
[2-306]
-----
M
N
-
L
-
I
F
L
G
T
S
A
G
V
--
P
T
--------------------
R
------------------
T
R
N
V
T
A
I
L
L
---
N
L
Q
----
H
P
T
---
Q
-
S
-
G
L
W
L
F
D
C
G
E
G
T
Q
H
Q
---
L
L
H
-------
T
A
-------------------------------------------------------
F
N
P
G
K
L
D
K
I
F
I
S
H
L
H
G
D
H
L
F
-------
G
L
P
G
L
L
C
S
R
S
M
--
S
----
G
I
I
----
Q
P
L
T
I
Y
G
P
Q
G
I
R
E
F
V
E
T
A
L
-
R
I
S
G
--
S
-----
W
---
T
--
D
Y
P
L
E
I
-
V
E
I
--
G
A
G
---
E
--
I
L
-
D
----
D
G
L
R
K
-
V
T
A
Y
P
L
E
H
P
----------------
L
-------------
E
--------
C
Y
G
-
Y
R
I
E
--------
E
H
D
A
P
G
A
L
N
A
Q
A
L
K
A
A
G
V
P
P
G
P
L
F
Q
------
E
L
K
A
G
K
T
I
T
L
E
D
G
R
Q
I
N
G
A
D
Y
L
A
A
P
V
P
G
K
A
L
A
I
F
G
D
--
T
-
G
P
C
D
-----
A
A
-----
L
D
L
A
-----
K
--
G
V
D
V
M
V
H
E
A
T
--
L
D
I
T
M
E
--------
A
K
A
N
S
R
G
H
-----
S
-
S
--
T
R
Q
A
-
A
---
T
L
A
R
E
----------
A
G
V
G
K
---------
L
I
I
T
H
V
S
S
R
Y
D
D
K
-
G
C
Q
H
L
L
R
E
C
R
S
I
-----
F
P
-
A
--
T
E
L
A
N
D
F
T
V
F
N
V
----------
22
HHSearch
75.50
28%
8
- C1 -
-
2FK6
2
RNZ_BACSU
A:
[1-307]
-----
M
E
-
L
-
L
F
L
G
T
G
A
G
I
--
P
A
--------------------
K
------------------
A
R
N
V
T
S
--
V
A
L
K
L
L
E
----
E
-----
R
-
R
-
S
V
W
L
F
D
C
G
E
A
T
Q
H
Q
---
M
L
H
-------
T
T
-------------------------------------------------------
I
K
P
R
K
I
E
K
I
F
I
T
H
M
A
G
D
H
V
Y
-------
G
L
P
G
L
L
G
S
R
S
F
--
Q
----
G
G
E
----
D
E
L
T
V
Y
G
P
K
G
I
K
A
F
I
E
T
S
L
-
A
V
T
K
--
T
-----
H
---
L
--
T
Y
P
L
A
I
-
Q
E
I
--
E
E
-
G
-
I
V
--
F
E
-
D
----
D
Q
F
I
--
V
T
A
V
S
V
I
H
G
----------------
V
-------------
E
--------
A
F
G
-
Y
R
V
Q
--------
E
K
D
V
P
G
S
L
K
A
D
V
L
K
E
M
N
I
P
P
G
P
V
Y
Q
------
K
I
K
K
G
E
T
V
T
L
E
D
G
R
I
I
N
G
N
D
F
L
E
P
P
K
K
G
R
S
V
V
F
S
G
D
--
T
-
R
V
S
D
-----
K
L
-----
K
E
L
A
-----
R
--
D
C
D
V
M
V
H
E
A
T
-
F
A
K
E
D
R
K
--------
L
A
Y
D
-
Y
Y
H
-----
S
-
T
--
T
E
Q
A
-
A
---
V
T
A
K
E
----------
A
R
A
K
Q
---------
L
I
L
T
H
I
S
A
R
Y
Q
G
D
A
S
-
L
E
L
Q
K
E
A
V
D
V
-----
F
P
---
N
S
V
A
A
Y
D
F
L
E
V
N
V
P
R
G
-------
24
HHSearch
74.38
28%
5
- C1 -
-
1Y44
2
RNZ_BACSU
B:
[1-307]
-----
M
E
-
L
-
L
F
L
G
T
G
A
G
I
--
P
A
--------------------
K
------------------
A
R
N
V
T
S
--
V
A
LK
L
L
E
----
E
-----
R
-
R
-
S
V
W
L
F
D
C
G
E
A
T
Q
H
Q
---
M
L
H
-------
T
T
-------------------------------------------------------
I
K
P
R
K
I
E
K
I
F
I
T
H
M
H
G
D
H
V
Y
-------
G
L
P
G
L
L
G
S
R
S
F
--
Q
----
G
G
E
----
D
E
L
T
V
Y
G
P
K
G
I
K
A
F
I
E
T
S
L
-
A
V
T
K
--
T
-----
H
---
L
--
T
Y
P
L
A
I
-
Q
E
I
--
E
E
-
G
-
I
V
--
F
E
-
D
----
D
Q
F
I
--
V
T
A
V
S
V
I
H
G
----------------
V
-------------
E
--------
A
F
G
-
Y
R
V
Q
--------
E
K
D
V
P
G
S
L
K
A
D
V
L
K
E
M
N
I
P
P
G
P
V
Y
Q
------
K
I
K
K
G
E
T
V
T
L
E
D
G
R
I
I
N
G
N
D
F
L
E
P
P
K
K
G
R
S
V
V
F
S
G
D
--
T
-
R
V
S
D
-----
K
L
-----
K
E
L
A
-----
R
--
D
C
D
V
M
V
H
E
A
T
-
F
A
K
-------------------
H
-----
S
-
T
--
T
E
Q
A
-
A
---
V
T
A
K
E
----------
A
R
A
K
Q
---------
L
I
L
T
H
I
S
A
R
Y
Q
G
D
A
S
-
L
E
L
Q
K
E
A
V
D
V
-----
F
P
---
N
S
V
A
A
Y
D
F
L
E
V
N
V
P
R
G
-------
2
PsiBlast_PDB
73.39
30%
10
- C1 -
-
4GCW
1
RNZ_BACSU
A:
[1-275]
-----
M
E
-
L
-
L
F
L
G
T
G
A
G
I
--
P
A
--------------------
K
------------------
A
R
N
V
T
S
--
V
---
A
L
K
LL--
E
E
R
---
R
-
S
-
V
W
-
L
F
D
C
G
E
A
T
Q
H
Q
---
M
L
H
-------
T
T
-------------------------------------------------------
I
K
P
R
K
I
E
K
I
F
I
T
H
M
H
G
D
H
V
Y
-------
G
L
P
G
L
L
G
S
R
S
F
--
Q
----
G
G
E
----
D
E
L
T
V
Y
G
P
K
G
I
K
A
F
I
E
T
S
L
-
A
V
T
K
--
T
-----
H
---
L
--
T
Y
P
L
A
I
-
Q
E
I
--
E
E
G
I
V
F
E
--
D
-------
D
Q
F
I
--
V
T
A
V
S
V
I
H
G
----------------
V
-------------
E
--------
A
F
G
-
Y
R
V
Q
--------
E
K
D
V
P
G
S
L
K
A
D
V
L
K
E
M
N
I
P
P
G
P
V
Y
Q
------
K
I
K
K
G
E
T
V
T
L
E
D
G
R
I
I
N
G
N
D
F
L
E
P
P
K
K
G
R
S
V
V
F
S
G
D
--
T
-
R
V
S
D
-----
K
L
-----
K
E
L
A
-----
R
--
D
C
D
V
M
V
H
E
A
T
-
F
A
K
E
D
-
R
--------
K
L
A
Y
D
Y
Y
H
-----
S
-
T
--
T
E
Q
A
-
A
---
V
T
A
K
E
----------
A
R
A
K
Q
---------
L
I
L
T
H
I
S
A
R
Y
Q
------------------------------------------------
3
PsiBlast_PDB
72.52
29%
8
- C1 -
-
2FK6
2
RNZ_BACSU
A:
[1-275]
-----
M
E
-
L
-
L
F
L
G
T
G
A
G
I
--
P
A
--------------------
K
------------------
A
R
N
V
T
S
--
V
---
A
L
K
LL--
E
E
R
---
R
-
S
-
V
W
-
L
F
D
C
G
E
A
T
Q
H
Q
---
M
L
H
-------
T
T
-------------------------------------------------------
I
K
P
R
K
I
E
K
I
F
I
T
H
M
A
G
D
H
V
Y
-------
G
L
P
G
L
L
G
S
R
S
F
--
Q
----
G
G
E
----
D
E
L
T
V
Y
G
P
K
G
I
K
A
F
I
E
T
S
L
-
A
V
T
K
--
T
-----
H
---
L
--
T
Y
P
L
A
I
-
Q
E
I
--
E
E
G
I
V
F
E
--
D
-------
D
Q
F
I
--
V
T
A
V
S
V
I
H
G
----------------
V
-------------
E
--------
A
F
G
-
Y
R
V
Q
--------
E
K
D
V
P
G
S
L
K
A
D
V
L
K
E
M
N
I
P
P
G
P
V
Y
Q
------
K
I
K
K
G
E
T
V
T
L
E
D
G
R
I
I
N
G
N
D
F
L
E
P
P
K
K
G
R
S
V
V
F
S
G
D
--
T
-
R
V
S
D
-----
K
L
-----
K
E
L
A
-----
R
--
D
C
D
V
M
V
H
E
A
T
-
F
A
K
E
D
-
R
--------
K
L
A
Y
D
Y
Y
H
-----
S
-
T
--
T
E
Q
A
-
A
---
V
T
A
K
E
----------
A
R
A
K
Q
---------
L
I
L
T
H
I
S
A
R
Y
Q
------------------------------------------------
4
PsiBlast_PDB
60.61
30%
11
- C1 -
-
1Y44
2
RNZ_BACSU
A:
[5-275]
-----------
F
L
G
T
G
A
G
I
--
P
A
--------------------
K
------------------
A
R
N
V
T
S
--
V
---
A
L
K
LL--
E
E
R
---
R
-
S
-
V
W
-
L
F
D
C
G
E
A
T
Q
H
Q
---
M
L
H
-------
T
T
-------------------------------------------------------
I
K
P
R
K
I
E
K
I
F
I
T
H
M
H
G
D
H
V
Y
-------
G
L
P
G
L
L
G
S
R
S
F
--
Q
----
G
G
E
----
D
E
L
T
V
Y
G
P
K
G
I
K
A
F
I
E
T
S
L
-
A
V
T
K
--
T
-----
H
---
L
--
T
Y
P
L
A
I
-
Q
E
I
--
E
E
G
I
V
F
E
--
D
-------
D
Q
F
I
--
V
T
A
V
S
V
I
H
G
----------------
V
-------------
E
--------
A
F
G
-
Y
R
V
Q
--------
E
K
D
V
P
G
S
L
--------------------------------------------
L
E
P
P
K
K
G
R
S
V
V
F
S
G
D
--
T
-
R
V
S
D
-----
K
L
-----
K
E
L
A
-----
R
--
D
C
D
V
M
V
H
E
A
T
-
F
A
K
E
D
-
R
--------
K
L
A
Y
D
Y
Y
H
-----
S
-
T
--
T
E
Q
A
-
A
---
V
T
A
K
E
----------
A
R
A
K
Q
---------
L
I
L
T
H
I
S
A
R
Y
Q
------------------------------------------------
38
HHSearch
57.52
22%
-29
- C1 -
-
3QH8
3
?
A:
[9-273]
----
C
L
R
-
F
-
T
L
L
G
C
G
S
S
P
GV
P
R
INGDWGKCDPKNPK------
N
------------------
R
R
R
R
A
S
--
L
---
L
V
E
----
R
Y
D
AEG
N
-
N
-
T
V
V
V
I
D
T
G
P
D
F
R
M
Q
---
M
I
D
-------
S
---------------------------------------------------------
G
V
H
M
L
D
A
A
V
Y
T
H
P
H
A
D
H
I
H
-------
G
I
D
D
L
R
T
Y
V
V
D
--------
N
G
----
R
L
M
D
V
Y
A
N
R
L
T
R
N
R
L
Y
D
T
F
-
G
Y
C
F
--
E
-----
T
PVG
S
SY
P
P
I
L
S
M
-
H
D
I
--
A
P
-
E
-
T
P
--
F
S
-
I
E
G
AG
G
A
I
R
--
F
E
P
F
S
Q
V
H
G
D---------------
I
-------------
E
--------
S
L
G
-
F
R
I
--------------------------------------------------------------------
G
S
V
V
Y
C
T
D
--
V
-
S
A
F
P
E----
Q
S
-----
L
Q
Y
I
-----
K
--
D
A
D
V
L
I
I
G
A
L
-
Q
Y
R
P
--------------
H
-
P
S
H
-----
F
-
S
--
L
G
E
A
-
L
---
E
W
I
E
K
----------
L
S
P
K
R
---------
A
I
L
T
H
M
H
V
P
L
D
Y
E
T
----
V
----
M
R
E
-----
T
P
-
H
-
H
V
E
P
G
Y
D
G
L
R
F
E
V
A
---------
29
HHSearch
56.73
21%
-46
* C1 *
-
1ZKP
-
?
D:
[24-267]
----
A
M
K
-
M
-
T
V
V
G
F
W
G
G
F
--
P
E
--------------------
A
------------------
G
E
A
T
S
G
--
Y
---
L
F
E
----
H
-----
D
-
G
-
F
R
L
L
V
D
C
G
S
G
V
L
A
Q
---
L
Q
K
-------
Y
--------------------------------------------------------
I
T
P
S
D
I
D
A
V
V
L
S
H
Y
H
H
D
H
V
A
-------
D
I
G
V
L
Q
Y
A
R
L
I
--
T
SATK
G
Q
L
----
P
E
L
P
I
Y
G
H
T
F
D
E
N
G
F
H
S
L
T
-
H
E
------------------
P
H
T
K
G
-
I
P
Y
--
N
P
-
E
-
E
T
--
L
Q
-
I
----
G
P
F
S
--
I
S
F
L
K
T
V
H
P
----------------
V
-------------
T
--------
C
F
A
-
M
R
I
T
--------
A
--------------------------------------------------------
G
N
D
I
V
V
Y
S
A
D
--
S
-
S
Y
I
P
-----
E
F
-----
I
P
F
T
-----
K
--
D
A
D
L
F
I
C
E
C
N
-
M
Y
A
H
Q
E
----------
A
A
K
-
A
G
H
-----
M
-
N
--
S
T
E
V
-
A
---
S
I
A
K
D
----------
A
N
V
K
E
---------
L
L
L
T
H
L
P
H
T
G
N
P
A
D
----
L
V
T
E
A
K
Q
I
-----
F
S
-
G
-
H
I
T
L
A
H
S
G
Y
V
W
N
-----------
30
HHSearch
55.22
21%
-31
- C1 -
-
3MD7
2
?
A:
[28-292]
----
C
L
R
-
F
-
T
L
L
G
C
G
S
S
P
--
G
V
PRINGDWGKCDPKNPK----
N
------------------
R
R
R
R
A
S
--
L
---
L
V
E
----
R
Y
D
AEG
N
-
N
-
T
V
V
V
I
D
T
G
P
D
F
R
M
Q
---
M
I
D
-------
S
---------------------------------------------------------
G
V
H
M
L
D
A
A
V
Y
T
H
P
H
A
D
H
I
H
-------
G
I
D
D
L
R
T
Y
V
V
D
--------
N
G
----
R
L
M
D
V
Y
A
N
R
L
T
R
N
R
L
Y
D
T
F
-
G
Y
C
F
--
E
-----
T
PVG
S
SY
P
P
I
L
S
M
-
H
D
I
--
A
P
-
E
-
T
P
--
F
S
-
I
E
G
AG
G
A
I
R
--
F
E
P
F
S
Q
V
H
G
D---------------
I
-------------
E
--------
S
L
G
-
F
R
I
--------------------------------------------------------------------
G
S
V
V
Y
C
T
D
--
V
-
S
A
F
P
E----
Q
S
-----
L
Q
Y
I
-----
K
--
D
A
D
V
L
I
I
G
A
L
-
Q
Y
R
P
--------------
H
-
P
S
H
-----
F
-
S
--
L
G
E
A
-
L
---
E
W
I
E
K
----------
L
S
P
K
R
---------
A
I
L
T
H
M
H
V
P
L
D
Y
E
----
T
V
----
M
R
E
-----
T
P
-
H
-
H
V
E
P
G
Y
D
G
L
R
F
E
V
A
---------
31
HHSearch
54.82
22%
-20
- C1 -
-
2E7Y
3
?
A:
[9-278]
----------------------------------------------------------------
A
L
F
S
--
T
---
W
I
Y
----
Y
-----
S
-
P
-
E
R
I
L
F
D
A
G
E
G
V
S
T
T
---
L
G
-----------------------------------------------------------------
S
K
V
Y
A
F
K
Y
V
F
L
T
H
G
H
V
D
H
I
A
-------
G
L
W
G
V
V
N
I
R
N
N
G
M
G
----
D
R
E
----
K
P
L
D
V
F
Y
P
E
G
N
R
A
-
V
E
E
Y
T
-
E
F
I
K
--
R
A
N
P--
D
---
L
--
R
F
S
F
N
V
-
H
P
L
--
K
E
-
G
-
E
R
--
V
F
-
L
R
N
A
-
G
G
F
K
R
Y
V
Q
P
F
R
T
K
H
V
----------------
S
S
E
-----------
V
--------
S
F
G
-
Y
H
I
F
--------
E
V
R
R
--
K
L
K
K
E
---
F
Q
G
L
D
S
-
K
E
I
S
------
R
L
V
-----------
K
E
K
G
R
D
F
V
T
E
E
Y
H
K
K
V
L
T
I
S
G
D
--
S
-
L
A
L
D
------------
P
E
E
I
-----
R
--
G
T
E
L
L
I
H
E
C
T
-
F
L
-------------------
N
H
-----
A
-
A
--
I
D
E
V
-
M
---
E
S
V
K
A
----------
A
G
V
K
K
---------
V
I
L
Y
H
I
S
T
R
Y
I
R
Q
L
--
K
S
V
I
K
K
Y
R
E
E
-----
M
P
D
V
-
E
I
L
Y
M
D
P
R
K
V
F
------------
47
Fugue
53.92
21%
1
- C1 -
-
1ZKP
-
?
A:
[18-268]
LYFQ
S
N
A
M
K
M
T
V
V
G
F
W
G
G
F
--
P
E
--------------------
A
------------------
G
E
A
T
S
G
--
Y
---
L
F
E
----
H
-----
D
-
G
-
F
R
L
L
V
D
C
G
S
G
V
L
A
Q
---
L
Q
K
-------
Y
--------------------------------------------------------
I
T
P
S
D
I
D
A
V
V
L
S
H
Y
H
H
D
H
V
A
-------
D
I
G
V
L
Q
Y
A
R
L
I
--
T
----
S
A
T
KGQL
P
E
L
P
I
Y
G
H
T
F
D
E
N
G
F
H
-------
S
--
L
-----
T
---
H
--
E
P
H
T
K
G
-
I
P
Y
--
N
P
E
E
--
T
--
L
Q
-
I
----
G
P
F
S
--
I
S
F
L
K
T
V
H
P
----------------
V
-------------
T
--------
C
F
A
M
R
I
T
A
-----------------------------------------------------------------
G
N
D
I
V
V
Y
S
A
D
--
S
-
S
Y
I
P
-----
E
F
-----
I
P
F
T
-----
K
--
D
A
D
L
F
I
C
E
C
N
M
Y
A
H
Q
E
A
A
--------
K
A
-----
G
-----
H
M
N
--
S
T
E
V
-
A
---
S
I
A
K
D
----------
A
N
V
K
E
---------
L
L
L
T
H
L
P
H
T
G
N
P
----
A
D
L
V
T
E
A
K
Q
I
-----
F
S
-
G
-
H
I
T
L
A
H
S
G
Y
V
W
N
S
----------
27
HHSearch
47.68
16%
-6
- C1 -
-
4Z6X
-
PQQB_PSEPK
A:
[1-307]
----
M
M
Y
-
I
-
Q
V
L
G
S
A
A
G
G
--
G
F
PQWNCNC
V
N
C
K
G
Y
R
D
GTLK
A
T
------------------
A
R
T
Q
S
S
--
I
---
A
L
S
----
D
-----
D
-
G
V
H
W
I
L
C
N
A
S
P
D
I
R
A
Q
---
L
Q
A
-------
F
A
PMQPARA------------------------------------------------
L
R
D
T
G
I
N
A
I
V
L
L
D
S
Q
I
D
H
T
T
-------
G
L
L
S
L
R
E
-------------
G
----
C
P
H
Q
V
W
C
T
D
M
V
H
Q
D
L
T
T
G
F
-
P
L
F
N
--
M
-----
L
---
S
HW
N
G
G
L
Q
W
-
N
R
I
--
E
L
-
E
-
G
S
--
F
V
-
I
DAC-
P
N
L
K
--
F
T
P
F
P
L
R
S
A
----------------
A
PPYSPHRFDPHPG
D
--------
N
L
G
-
L
M
V
E
--------
D
T
R
------------------------------------------------------
T
G
G
K
L
F
Y
A
P
G
--
L
G
Q
V
D
E
-----
K
L
-----
L
A
M
M
-----
H
--
G
A
D
C
L
L
V
D
G
T
-
L
W
E
D
D
E
M
Q
R
R
GVGTR
T
G
R
E
-
M
G
H
-----
L
-
A
--
Q
N
G
P
-
G
G
T
L
E
V
L
D
G
----------
F
P
R
Q
R
---------
K
V
L
I
H
I
N
N
T
N
P
I
L
D
---
E
N
S
P
E
R
A
E
V
-----
L
R
-
R
-
G
V
E
V
A
F
D
G
M
S
I
E
L
L
E
H
-------
39
HHSearch
46.44
18%
23
- C1 -
-
4OJV
1
PDE1_YEAST
A:
[3-369]
----
V
F
E
-
I
-
T
I
L
G
A
N
G
G
P
---
T
---------------------------------------
E
Y
G
T
Q
C
--
F
---
I
L
K
P
A
RT
E
-----
D
-
P
-
E
L
I
A
V
D
G
G
A
G
M
Y
Q
L
R
E
M
L
V
Q
-------
G
-DD
E
L
V
P
S
FYEHDREP
I
E
F
F
I
DSKLNIQKGLS
K
S
L
L
Q
S
L
K
RQ
G
E
H
F
E
S
AN
T
M
K
K
T
Y
E
V
F
Q
G
I
T
D
Y
Y
I
T
H
P
H
L
D
H
I
S
-------
G
L
V
V
N
S
P
S
I
Y
E
--
Q
----
E
N
S
----
K
K
K
T
I
W
G
L
P
H
T
I
D
V
L
Q
K
H
V
F
N
D
L
I
--
W
PDL--
T
AE-
R
--
S
R
K
L
K
L
-
K
C
L
--
N
P
-
K
-
E
V
QK
C
T
-
I
----
F
P
W
D
--
V
I
P
F
K
V
H
H
G
----------------
I
-------------
G
VKTG
A
P
V
Y
S
T
F
-
Y
I
F
R
--------
D
R
K
------------------------------------------------------
S
K
D
C
I
I
V
C
G
D
--
V
-
E
Q
D
R
RESEE
S
L
L
E
E
F
W
S
Y
V
A
E
N
IPL
V
--
H
L
K
G
I
L
V
E
C
S
-
C
P
L
S
S
K
P
---------
E
Q
L
-
Y
G
H
-----
L
-
S
--
P
I
Y
L
-
I
---
N
E
L
S
N
L
N
T
L
Y
NSSKG
L
S
G
L
N
---------
V
I
V
T
H
V
K
S
T
P
A
K
R
D
P
R
L
T
I
L
E
E
L
R
F
L
A
E
E
R
N
L
G
-
D
L
R
I
S
I
A
L
E
G
H
T
L
F
L
----------
28
HHSearch
46.07
16%
-6
- C1 -
-
4Z67
1
PQQB_PSEPK
A:
[1-307]
----
M
M
Y
-
I
-
Q
V
L
G
S
A
A
G
G
--
G
F
PQWNCNC
V
N
C
K
G
Y
R
D
GTLK
A
T
------------------
A
R
T
Q
S
S
--
I
---
A
L
S
----
D
-----
D
-
G
V
H
W
I
L
C
N
A
S
P
D
I
R
A
Q
---
L
Q
A
-------
F
A
PMQPARA------------------------------------------------
L
R
D
T
G
I
N
A
I
V
L
L
D
S
Q
I
D
H
T
T
-------
G
L
L
S
L
R
E
-------------
G
----
C
P
H
Q
V
W
C
T
D
M
V
H
Q
D
L
T
T
G
F
-
P
L
F
N
--
M
-----
L
---
S
HW
N
G
G
L
Q
W
-
N
R
I
--
E
L
-
E
-
G
S
--
F
V
-
I
DAC-
P
N
L
K
--
F
T
P
F
P
L
R
S
A
----------------
A
P
PYSPHRFDPHPG
D
--------
N
L
G
-
L
M
V
E
--------
D
T
R
------------------------------------------------------
T
G
G
K
L
F
Y
A
P
G
--
L
G
Q
V
D
E
-----
K
L
-----
L
A
M
M
-----
H
--
G
A
D
C
L
L
V
D
G
T
-
L
W
E
D
D
E
M
Q
R
R
GVGTR
T
G
R
E
-
M
G
H
-----
L
-
A
--
Q
N
G
P
-
G
G
T
L
E
V
L
D
G
----------
F
P
R
Q
R
---------
K
V
L
I
H
I
N
N
T
N
P
I
L
D
---
E
N
S
P
E
R
A
E
V
-----
L
R
-
R
-
G
V
E
V
A
F
D
G
M
S
I
E
L
L
E
H
-------
48
Fugue
46.06
20%
-8
- C1 -
-
1WW1
-
?
A:
[1-280]
----------------
M
N
I
--
I
G
--------------------
F
------------------
S
K
A
L
F
S
--
T
---
W
I
Y
----
Y
S
P
---
E
-
R
---
I
L
F
D
A
G
E
G
V
S
T
T
---
L
----------
G
-------------------------------------------------------
S
K
V
Y
A
F
K
Y
V
F
L
T
H
G
H
V
D
H
I
A
-------
G
L
W
G
V
V
N
I
R
N
N
GM
G
----
D
R
E
----
K
P
L
D
V
F
Y
P
E
G
N
R
A
V
E
E
Y
T
E
-
F
I
K
R
A
N
P
-----
D
---
L
--
R
F
S
F
N
V
-
H
P
L
K
E
G
E
R
V
F
L
R
--
N
A
-
G
----
G
F
K
R
--
Y
V
Q
P
F
R
T
K
S
----------------
E
-------------
V
--------
S
F
G
-
Y
H
I
F
--------
E
V
R
R
K
F
V
-----------------
T
------
E
E
Y
H
K
K
V
L
T
I
S
-
G
---------------------------
D
S
L
A
-----
L
D
-----
P
E
E
I
-----
R
--
G
T
E
L
L
I
H
E
C
T
-
F
L
D
---------------
A
R
D
N
H
-----
A
-
A
--
I
D
E
V
-
M
---
E
S
V
K
A
----------
A
G
V
K
K
---------
V
I
L
Y
H
I
S
T
R
Y
-
I
R
Q
L
K
S
V
I
K
K
Y
R
E
E
M
-----
P
D
-
V
-
E
I
L
Y
M
D
P
R
K
V
F
E
M
----------
51
Fugue
45.40
17%
14
- C1 -
-
4OJV
1
PDE1_YEAST
A:
[1-369]
--MV
V
F
E
-
I
-
T
I
L
G
A
N
G
G
P
--
T
E
--------------------
Y
------------------
G
T
Q
C
F
I
--
L
---
K
P
A
----
R
T
E
---
D
-
P
-
E
L
I
A
V
D
G
G
A
G
M
Y
Q
L
---
R
E
M
-------
L
V
-------------------------------------------------------
Q
G
D
D
E
L
V
P
S
F
Y
E
H
D
R
E
P
I
E
F
F
I
DSKLN
I
Q
K
G
L
S
K
S
L
L
Q
--
S
----
L
K
R
----
Q
G
E
H
F
E
S
A
N
T
M
K
K
T
Y
E
V
F
Q
-
G
I
T
D
--
Y
Y
I
THP
H
---
L
--
D
H
I
S
G
L
-
V
V
N
--
S
P
S
I
Y
E
Q
--
E
N
-
S
----
K
K
K
T
--
I
W
G
--
L
P
H
T
----------------
I
-------------
D
--------
V
L
Q
-
K
H
V
F
NDLIWPDL
T
A
E
R
S
R
K
L
K
L
K
C
L
N
P
K
E
V
Q
K
C
T
I
F
P
W
D
V
I
P
F
K
V
H
H
G
I
G
V
K
T
G
-
A
P
V
Y
S
T
F
Y
I
F
R
D
R
K
S
K
D
C
I
I
V
C
G
D
V
E
Q
-
D
R
R
E
SEES-
L
L
-----
E
E
F
W
-----
S
--
Y
V
A
E
N
I
P
L
V
H
-
L
K
G
I
L
V
E
CSC-----
P
L
S
S
K
P
E
Q
LYGHL
S
-
P
--
I
Y
L
I
-
N
---
E
L
S
N
L
----------
N
T
L
Y
N
SSKGLSG
L
N
V
I
V
T
H
V
K
S
T
P
A
K
R
D
P
R
L
T
I
L
E
E
L
R
F
L
-----
A
E
-
E
-
R
N
L
--
G
D
L
-
R
I
S
I
A
L
E
G
H
T
L
F
L
-
33
HHSearch
44.22
19%
-28
- C1 -
-
3G1P
-
PHNP_ECOLI
B:
[2-251]
----
S
L
T
-
L
-
T
L
T
G
T
G
G
A
Q
--
G
V
--------------------
P
AWGCECAACARARRSPQY
R
R
Q
P
C
S
--
G
---
V
V
K
----
F
-----
N
-
D
-
A
I
T
L
I
D
A
G
L
H
D
L
A
D
--------------
R
-------------------------------------------------------
W
S
P
G
S
F
Q
Q
F
L
L
T
H
Y
H
M
D
H
V
Q
-------
G
L
F
P
L
R
W
G
V
-----------
G
----
D
P
I
P
V
Y
G
P
P
D
E
Q
G
C
D
D
L
F
K
-
H
P
-
G
-----------------
L
L
D
F
S
H
T
V
--
E
P
-
F
-
V
V
--
F
D
-
L
----
Q
G
L
Q
--
V
T
P
L
P
L
N
H
S
----------------
K
-------------
L
--------
T
F
G
-
Y
L
L
E
--------
T
--------------------------------------------------------
A
H
S
R
V
A
W
L
S
D
--
T
-
A
G
L
P
E----
K
T
-----
L
K
F
L
-----
R
NN
Q
P
Q
V
M
V
M
D
C
S
-
H
P
P
R
A
D
A
-----------
P
-
R
N
H
-----
C
-
D
--
L
N
T
V
-
L
---
A
L
N
Q
V
----------
I
R
S
P
R
---------
V
I
L
T
H
I
S
H
Q
F
D
A
W
L
M
--------
E
N
A
-----
L
P
-
S
-
G
F
E
V
G
F
D
G
M
E
I
G
V
----------
45
HHSearch
43.00
16%
-75
- C1 -
-
3X2Y
-
Y1162_THEMA
A:
[1-227]
----
G
M
K
-
V
-
T
F
L
G
A
---------------------------------------------------
A
V
--
V
---
L
I
E
----------
G
-
K
-
K
N
I
I
I
D
P
F
I
S
G
N
P
V
---
C
P
V
-------
K
L
-------------------------------------------------------
E
G
L
P
K
I
D
Y
I
L
V
T
H
G
H
G
D
H
L
G
-------
D
A
V
E
I
A
K
K
-----------------
N
D
A
T
V
I
S
N
Y
E
I
C
H
Y
L
G
K
K
G
-----------------------
V
K
T
-
H
A
M
--
H
I
-
G
-
G
S
--
Y
L
-
F
----
D
F
G
R
--
V
K
M
T
P
A
V
H
G
----------------
S
G
I
L
D
GD
S
M
I
Y
G
G
-
N
--------
P
S
G
-
F
L
I
T
--------
I
--------------------------------------------------------
E
G
K
K
I
Y
H
A
G
D
--
T
-
G
L
T
R
-----
E
M
-----
E
L
L
A
E----
E
--
N
V
D
V
A
F
L
P
I
G
-
G
-------------------
N
F
V
-----
M
-
D
--
V
E
D
A
-
V
---
R
A
A
V
M
----------
I
K
P
K
K
---------
V
V
P
M
H
Y
G
T
W
E
L
I
F
A
D
V
E
L
F
K
K
K
V
E
E
------
K
G
-
V
-
E
C
V
I
L
E
P
G
E
S
L
E
L
----------
37
HHSearch
42.32
17%
7
- C1 -
-
4Z7R
-
PQQB_METEA
A:
[1-299]
-----
M
H
-
V
-
V
I
L
G
S
A
A
G
G
GV
P
Q
--------------------
W
NCRC
S
I
C
S
L
A
W
A
GDSR
V
R
P
R
T
Q
S
S
--
I
---
A
V
S
----
P
-----
D
G
E
-
R
W
L
L
L
N
A
S
P
D
I
R
Q
Q
---
I
Q
A
N
PQMHPR
E
G
-------------------------------------------------------
L
R
H
S
P
I
H
A
V
L
L
T
N
G
D
V
D
H
V
A
-------
G
L
L
T
L
R
E
G
-----------------
Q
P
F
T
L
Y
A
T
P
G
I
L
A
S
V
S
D
N
R
-
V
F
D
V
--
M
---------
A
--
A
D
V
V
K
R
-
Q
T
I
--
A
L
-
N
-
E
T
--
F
E
P
V
----
P
G
L
S
--
V
T
L
F
S
V
P
G
K
VPLWLEDASMEIGAET
E
-------------
T
--------
T
V
G
-
T
M
I
E
--------
A
--------------------------------------------------------
G
G
K
R
L
A
Y
I
P
G
--
C
-
A
R
V
T
E
----
D
L
-----
K
A
R
I
-----
A
--
G
A
D
A
L
L
F
D
G
T
-
V
L
E
D
D
D
M
I
R
A
GVGTK
T
G
W
R
-
M
G
H
-----
I
-
Q
MN
G
E
T
G
S
I
---
A
S
L
A
D
----------
I
E
I
G
R
---------
R
V
F
V
H
I
N
N
T
N
P
V
L
I
E
--
D
S
Y
E
R
-
A
S
V
-----
E
A
-
R
-
G
W
T
V
A
H
D
G
L
T
L
D
L
----------