@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKB1: (2017-10-25 )
MTSGFETLNLHPQLKKAIDALGFTQMTPIQQKVLKYTLAGHDAIGRAQTGTGKTAAFLISVINDLLNNPVQEQRFRGEPRALILAPTRELALQIESDAKSLTKFSNLHLVTLLGGVDFDKQKKQLDANFVDIMVATPGRLIDFVEQKEVWLDQIEFLVIDEADRLLDMGFIPSVKRIVRYSPRKEQRQTLMFSATFSYDVLNLARQWLFEPVTVEIEPEQKTNNDVEQRVYVVAKQDKYRLLQDILREEPIDKVMIFANRRDQVRRLYDHLKKDGYKVGMLSGEIAQDKRLKMLEQFKQGKHNIMIATDVAGRGIHVEGVSHVVNFTLPEQSDDYVHRIGRTGRAGAQGVSISFLSEDDAFYLPEIEKAIGKKLPLTRLDGYC
Atome Classification :
(26 SA)
.........10........20........30........40........50........60..--......--70.--.....-..80........90........100.-......110.......120.......130.......140.......150.......160.......170.......180.....--....190.......200.......210.......220.......230.....-..240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTSGFETLNL
H
P
Q
L
K
K
A
I
D
A
LGFTQMT
P
I
Q
Q
K
V
L
K
Y
T
LAGHDAIGRAQTGT
G
K
T
A
A
F
L
I
S
V
I
N
--
D
L
LNN
P
--
V
Q
E
--
Q
RFRG-EP
R
A
L
I
LAPTR
E
L
A
L
Q
IES
D
A
K
S
L
T
K-FSN
L
H
L
V
T
L
LGGVD
F
D
K
Q
K
K
QLDA
N
F
V
D
I
M
VATP
G
R
L
I
D
F
V
E
Q
K
E
V
W
L
D
Q
I
E
F
L
V
IDEA
D
R
L
L
DMG
F
I
P
S
V
K
R
I
VRY--SP
R
K
E
--
Q
R
Q
T
L
M
F
S
ATF
S
Y
D
V
L
N
L
A
R
Q
WLFEP
V
T
V
E
I
EPEQKTNN
D
V
E
Q
R
V
Y
V
V
AKQ
D
-
K
Y
R
L
L
Q
D
I
L
R
EEPI
D
K
V
M
I
FANR
R
D
Q
V
R
R
L
Y
D
H
L
K
KDG
Y
K
V
GMLSGEI
A
Q
D
K
R
L
K
M
L
E
Q
F
KQGKH
N
I
M
I
A
TDVAGR
G
I
H
V
EG
V
S
H
V
V
N
FTLPEQS
D
D
Y
V
H
R
IGRTGRAGAQ
G
V
S
I
S
F
LSEDDAF
Y
L
P
E
I
E
K
A
IGKKLPLTRLDGYC
24
PsiBlast_CBE
88.83
35%
-114
- C2 -
-
2DB3
2
VASA1_DROME
B:
[58-416]
----
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
--
K
L
L
E
D
P
--
H
E
L
--
E
L
--
G
-
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
--
V
T
M
R
P
--
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
Q
-
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
-------
P
E
K
D
R
A
I
A
A
D
L
---------
22
PsiBlast_CBE
88.48
35%
-112
- C2 -
-
2DB3
2
VASA1_DROME
D:
[58-416]
----
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
--
K
L
L
E
D
P
--
H
E
L
--
E
L
--
G
-
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
--
V
T
M
R
P
--
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
Q
-
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
-------
P
E
K
D
R
A
I
A
A
D
L
---------
23
PsiBlast_CBE
88.26
35%
-112
- C2 -
-
2DB3
2
VASA1_DROME
C:
[58-416]
----
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
--
K
L
L
E
D
P
--
H
E
L
--
E
L
--
G
-
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
--
V
T
M
R
P
--
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
Q
-
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
-------
P
E
K
D
R
A
I
A
A
D
L
---------
9
PsiBlast_PDB
88.00
35%
-113
- C2 -
-
2DB3
2
VASA1_DROME
A:
[58-416]
----
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
--
K
L
L
E
D
P
--
H
E
L
--
E
L
--
G
-
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
T
R
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
--
V
T
M
R
P
--
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
Q
-
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
-------
P
E
K
D
R
A
I
A
A
D
L
---------
119
HHSearch
86.92
36%
-114
- C2 -
-
2DB3
2
VASA1_DROME
A:
[57-407]
---
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
--
K
L
L
E
D
P
--
H
E
----
L
E
L
G
-
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
E
D
M
R
R
I
M
T
H
--
V
T
M
R
P
--
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
K
Y
A
-
K
R
S
K
L
I
E
I
L
S
E
-
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
-------------------------
113
HHSearch
82.39
37%
-111
- C2 -
-
5IVL
-
?
B:
[4-351]
----
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
T
P
I
Q
A
K
T
I
P
L
S
L
Q
N
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
--
K
V
D
V
K
-----------
N
G
-
A
I
Q
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
I
G
A
-
V
K
R
V
R
V
L
P
I
Y
G
G
Q
D
I
E
R
Q
I
R
-
A
L
K
K
H
P
H
V
I
V
G
T
P
G
R
I
I
D
H
I
N
R
G
T
L
R
L
E
H
V
H
T
V
V
L
D
E
A
D
E
M
L
--
G
F
I
E
D
I
E
A
I
L
S
H
--
V
P
--
A
--
E
R
Q
T
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
E
L
V
K
V
K
A
----
V
P
N
I
Q
Q
Y
Y
L
E
V
H
E
K
K
-
K
F
D
I
L
T
R
L
L
D
I
Q
A
P
E
L
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
Q
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
T
P
R
E
------------------------
123
HHSearch
82.22
32%
-135
- C2 -
-
1S2M
-
DHH1_YEAST
A:
[46-400]
--
N
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
--
K
V
K
P
K
-----------
L
N
-
K
I
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
-
H
C
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
T
I
I
E
Q
I
L
S
F
--
L
P
--
P
--
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
-
L
T
L
K
G
I
T
Q
Y
Y
A
F
V
E
E
R
Q
-
K
L
H
C
L
N
T
L
F
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
E
Q
---------------
117
HHSearch
82.07
38%
-13
- C2 -
-
4D25
3
?
A:
[51-409]
---
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
--
M
L
L
Q
D
P
--
K
D
L
I
S
E
N
G
C
A
-
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
-
G
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
PT
M
V
E
T
T
--
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
K
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
------------------------
116
HHSearch
81.56
38%
-15
- C2 -
-
4D26
2
?
A:
[51-409]
---
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
--
M
L
L
Q
D
P
--
K
D
L
I
S
E
N
G
C
A
-
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
-
G
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
PT
M
V
E
T
T
--
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
K
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
------------------------
2
PsiBlast_PDB
80.22
37%
-14
- C2 -
-
4D25
3
?
A:
[52-408]
----
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
--
M
L
L
Q
D
P
KD
L
I
S
--
E
N
G
C
A
-
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
-
G
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
--
P
T
M
V
E
TT
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
K
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
-------------------------
12
PsiBlast_PDB
79.96
32%
-88
- C2 -
-
3EX7
3
IF4A3_HUMAN
C:
[36-394]
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
--
C
L
---
D
--
I
Q
V
--
R
-----
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
P
--
P
--
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
Q
---------------
15
PsiBlast_PDB
79.91
32%
-86
- C2 -
-
2J0S
2
IF4A3_HUMAN
A:
[35-393]
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
--
C
L
---
D
--
I
Q
V
--
R
-----
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
P
--
P
--
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
Q
---------------
3
PsiBlast_PDB
79.86
37%
-16
- C2 -
-
4D26
2
?
A:
[52-408]
----
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
--
M
L
L
Q
D
P
K
D
L
I
S
--
E
N
G
C
A
-
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
-
G
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
--
P
T
M
V
E
TT
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
K
Y
E
-
K
R
N
S
L
K
Q
L
I
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
-------------------------
27
PsiBlast_CBE
79.43
32%
-83
- C2 -
-
2XB2
1
IF4A3_HUMAN
X:
[36-394]
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
--
C
L
---
D
--
I
Q
V
--
R
-----
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
P
--
P
--
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
Q
---------------
14
PsiBlast_PDB
79.37
32%
-81
- C2 -
-
2J0Q
2
IF4A3_HUMAN
A:
[35-393]
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
--
C
L
---
D
--
I
Q
V
--
R
-----
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
P
--
P
--
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
Q
---------------
28
PsiBlast_CBE
79.36
32%
-81
- C2 -
-
2J0Q
2
IF4A3_HUMAN
B:
[35-393]
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
--
C
L
---
D
--
I
Q
V
--
R
-----
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
P
--
P
--
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
Q
---------------
13
PsiBlast_PDB
79.25
32%
-82
- C2 -
-
2XB2
1
IF4A3_HUMAN
A:
[36-394]
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
--
C
L
---
D
--
I
Q
V
--
R
-----
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
P
--
P
--
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
Q
---------------
11
PsiBlast_PDB
79.18
32%
-87
- C2 -
-
2HYI
2
IF4A3_HUMAN
C:
[36-394]
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
--
C
L
---
D
--
I
Q
V
--
R
-----
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
P
--
P
--
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
Q
---------------
25
PsiBlast_CBE
79.01
32%
-82
- C2 -
-
3EX7
3
IF4A3_HUMAN
H:
[36-394]
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
--
C
L
---
D
--
I
Q
V
--
R
-----
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
P
--
P
--
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
Q
---------------
26
PsiBlast_CBE
78.51
32%
-83
- C2 -
-
2HYI
2
IF4A3_HUMAN
I:
[36-394]
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
--
C
L
---
D
--
I
Q
V
--
R
-----
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
--
L
P
--
P
--
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
E
Q
---------------
73
PsiBlast_CBE
57.63
40%
-49
- C2 -
-
3NBF
2
?
A:
[3-205]
----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
--
R
L
--
A
P
--
S
Q
E
-----
R
G
R
K
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
---
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
E
E
V
E
A
L
L
S
A
--
T
P
--
P
--
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
57.33
40%
-52
- C2 -
-
3NBF
2
?
B:
[3-205]
----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
--
R
L
--
A
P
--
S
Q
E
-----
R
G
R
K
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
---
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
E
E
V
E
A
L
L
S
A
--
T
P
--
P
--
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
57.13
40%
-53
- C2 -
-
3NBF
4
?
C:
[3-205]
----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
--
R
L
--
A
P
--
S
Q
E
-----
R
G
R
K
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
---
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
E
E
V
E
A
L
L
S
A
--
T
P
--
P
--
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
55.47
40%
-57
- C2 -
-
3NBF
2
?
D:
[3-205]
----
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
K
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
--
R
L
--
A
P
--
S
Q
E
-----
R
G
R
K
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
---
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
E
E
V
E
A
L
L
S
A
--
T
P
--
P
--
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
51.13
31%
-43
- C2 -
-
1VEC
1
DDX6_HUMAN
B:
[5-202]
----
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
RL
D
L
K
K
D
N
--
I
Q
------------
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
D
-
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
G
V
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
D
F
V
Q
I
M
E
D
I
I
L
T
--
L
P
K
----
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
E
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
38.33
34%
-133
- C2 -
-
4DB2
4
MS116_YEAST
C:
[53-154]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
E
F
K
K
D
-
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
L
P
F
V
R
E
L
E
D
A
--------------