@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKB4: (2017-10-25 )
MAEFKFTDLVEPVAVDKKTALRITVLGGGSFGTAMANLAARNGCDTMIWIRDAETAEEINKTHINKRYLPDFTLESSLRAVSDLEQAVCDRDIILVAIPSHSFRDVLKQIAPYITAQAVVSLTKGIEAKTFSFMSDIIREELPEVPYGVLSGPNLAKEIMAGMPSGTVIASDSELVRYAVQHALHSALFRVFGSDDVHGVELGGALKNIYAVAMGIGAAYKIGENTKSMILTRALAEMSRFAVKQGANPLTFLGLSGVGDLFATCNSPLSRNYQIGYALGSGKTLEQASKELGQTAEGINTIVQVRGKAQELDVYMPITNALYEVIFEGAPPLNIALSLMKNGHRSDVEFVLPHHEV
Atome Classification :
(20 SA)
.........10........20........30........40.-------..--------.---------....50..-----..-----....60........70........80........90........100.......110..------.-...------.-120-.....--.--.130-........140.......150.......160.......170------....---------.....180..-...--..190.......200.......210.......220.......230.......240---.....--..250.-......260.......270..-..--------------.-----..280---------..----.......290--...--....300.....--..310..--.--....320.......330.......340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAEFKFTDLVEPVAVDKK
T
A
L
R
I
T
V
LGGG
S
F
G
T
A
M
A
N
L
A
ARN-------GC--------
D
---------
T
M
I
W
I
RDA-----
E
T
-----
A
E
E
I
N
K
THINKRYLPD
F
T
L
E
S
S
L
R
A
V
S
D
L
E
Q
A
VCDR
D
I
I
L
V
A
IP
S
H
S
F
R
D
V
L
K
Q
I
A
P
Y
I
------
T
-
A
Q
A
------
V
-
V
S
L
-
T
KGIE--
A
--
K
T
F
--
S
F
M
S
D
I
I
R
E
ELPEVPYGVLSG
P
N
L
A
K
E
I
M
AGMPS
G
T
V
IA--------S
D
S
E
---------
L
V
R
Y
A
V
Q
H
A
L
-
H
S
A
--
L
F
R
V
FGSDDV
H
G
V
E
L
G
G
A
L
K
N
I
Y
A
V
A
MGIG
A
A
Y
KIGE
N
T
K
S
M
I
L
T
R
A
L
A
E
M
S
R
F
A
---
V
K
QGA--N
P
L
T
F
L
-GLSG
V
G
D
L
F
A
TCNSPLSRN
Y
Q
-
I
G
--------------
Y
-----
A
LG-----------SG----
K
T
L
E
Q
A
S
K
E
L--G
Q
T
--
A
E
G
I
N
T
I
V
Q
VRG--KAQ
E
L
D
V
--
Y
--M
P
I
T
N
A
L
Y
E
V
I
FEGAP
P
L
N
I
A
L
S
L
M
KNGHRSD
V
E
F
VLPHHEV
1
PsiBlast_PDB
87.64
34%
-65
* C2 *
-
3K96
1
GPDA_COXBU
A:
[32-352]
----------------------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
-------
G
Q
--------
K
---------
V
R
L
W
S
Y
E
S
-----
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
M
K
P
L
I
------
D
-
A
K
T
------
R
-
I
A
W
G
T
K
G
L
---
A
--
K
G
S
--
R
L
L
H
E
V
V
A
T
E
L
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
--------
S
N
N
S
---------
Q
F
S
K
D
L
I
E
R
L
-
H
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
---
S
V
F
G
G
--
K
Q
E
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
-
F
G
--------------
L
-----
A
L
G
-----------
E
G
----
V
D
K
K
E
A
Q
Q
A
I
--
G
Q
A
--
I
E
G
L
Y
N
T
D
Q
V
H
A
--
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
--------------
21
PsiBlast_CBE
85.91
34%
-67
- C2 -
-
3K96
2
GPDA_COXBU
B:
[32-351]
----------------------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
-------
G
Q
--------
K
---------
V
R
L
W
S
Y
E
S
-----
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
M
K
P
L
I
------
D
-
A
K
T
------
R
-
I
A
W
G
T
K
G
L
---
A
--
K
G
S
--
R
L
L
H
E
V
V
A
T
E
L
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
--------
S
N
N
S
---------
Q
F
S
K
D
L
I
E
R
L
-
H
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
---
S
V
F
G
G
--
K
Q
E
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
-
F
G
--------------
L
-----
A
L
G
-----------
E
G
----
V
D
K
K
E
A
Q
Q
A
I
--
G
Q
A
--
I
E
G
L
Y
N
T
D
Q
V
H
A
--
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
---------------
61
HHSearch
82.77
31%
-59
- C2 -
-
3K96
1
GPDA_COXBU
A:
[27-352]
-----------------
P
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
-------
G
Q
--------
K
---------
V
R
L
W
S
Y
E
S
-----
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
M
K
P
L
I
------
D
A
K
T
R
------
I
-
A
W
G
-
T
K
G
L
A
--
K
--
G
S
R
---
L
L
H
E
V
V
A
T
E
L
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
--------
S
N
N
S
---------
Q
F
S
K
D
L
I
E
R
L
-
H
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
---
S
V
F
G
G
--
K
Q
E
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
--------------
A
L
G
E
GV
D
K
K
E
A
Q
Q
A
------
I
G
----
Q
A
I
E
-------------
G
L
Y
N
--
T
D
Q
V
H
A
--
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
--------------
76
Fugue
80.65
29%
-50
- C2 -
-
1EVY
1
GPDA_LEIME
A:
[9-357]
-------------
K
D
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
------
I
-
A
Y
A
K
E
K
Q
V
P
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
-----
R
A
V
--
A
E
G
V
A
T
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
---
14
PsiBlast_PDB
79.90
29%
-
- C2 -
-
4FGW
-
GPD1_YEAST
A:
[35-379]
--------------------
F
K
V
T
V
I
G
S
G
N
W
G
T
T
I
A
K
V
V
A
E
N
--------
C
--------
K
G
Y
P
EVFAP
I
V
Q
M
W
V
F
E
E
-----
E
I
NGEK
L
T
E
I
I
N
T
R
H
Q
N
V
K
Y
L
P
G
I
T
L
P
D
N
L
V
A
N
P
D
L
I
D
S
V
K
D
V
D
I
I
V
F
N
I
P
H
Q
F
L
P
R
I
C
S
Q
L
K
G
H
V
------
D
-
S
H
V
R
-----
A
-
I
S
C
-
L
K
G
F
E
V
G
A
--
K
G
V
--
Q
L
L
S
S
Y
I
T
E
E
L
G
-
I
Q
C
G
A
L
S
G
A
N
I
A
T
E
V
A
Q
E
H
W
S
E
T
T
V
A
Y
H
IPKD
F
R
G
E
G
K
---------
D
V
D
H
K
V
L
K
A
L
F
H
R
P
--
Y
F
H
V
S
V
I
E
D
V
A
G
I
S
I
C
G
A
L
K
N
V
V
A
L
G
C
G
F
V
E
G
L
G
W
G
N
N
A
S
A
A
I
Q
R
V
G
L
G
E
I
I
R
F
G
Q
M
F
F
P
E
S
R
--
E
E
T
Y
Y
Q
-
E
S
A
G
V
A
D
L
I
T
T
C
A
G
--
G
R
N
V
K
-
V
A
--------------
R
-----
L
M
A
T
----------
S
G
----
K
D
A
W
E
C
E
K
E
L
LN
G
Q
S
--
A
Q
G
L
I
T
C
K
E
V
H
E
--
W
L
E
T
C
G
S
--
V
ED
F
P
L
F
E
A
V
Y
Q
I
V
Y
N
N
Y
P
M
K
N
L
----------------------
63
HHSearch
79.83
37%
-97
- C2 -
-
1Z82
7
?
A:
[14-325]
-------------------
E
M
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
E
N
-------
G
E
--------
E
---------
V
I
L
W
A
R
R
K
-----
E
I
-----
V
D
L
I
N
V
S
H
T
S
P
-
Y
V
E
E
S
--
K
I
T
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
E
H
L
L
R
L
P
V
--------
K
-
P
S
M
------
V
-
L
N
L
-
S
K
G
I
E
--
I
--
K
T
G
--
K
R
V
S
E
I
V
E
E
I
L
G
-
C
P
Y
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
--------
G
E
N
S
------------
K
E
L
Q
K
R
I
-
S
T
E
--
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
A
R
F
G
---
M
F
F
G
A
--
D
Q
K
T
F
M
-
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
-
F
G
--------------
E
-----
L
I
A
R
GFN
P
L
K
L
L
E
S
S
N
----
Q
V
V
E
---------------
G
A
F
T
V
K
A
V
M
K
--
I
A
K
E
N
K
I
--
D
--
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
----------------
62
HHSearch
79.61
31%
-59
- C2 -
-
3K96
2
GPDA_COXBU
B:
[27-351]
-----------------
P
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
-------
G
Q
--------
K
---------
V
R
L
W
S
Y
E
S
-----
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
M
K
P
L
I
------
D
A
K
T
R
------
I
-
A
W
G
-
T
K
G
L
A
--
K
--
G
S
R
---
L
L
H
E
V
V
A
T
E
L
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
--------
S
N
N
S
---------
Q
F
S
K
D
L
I
E
R
L
-
H
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
---
S
V
F
G
G
--
K
Q
E
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
--------------
A
LGEGV
D
K
K
EAQQA------
I
G
----
Q
A
I
E
-------------
G
L
Y
N
--
T
D
Q
V
H
A
--
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
---------------
6
PsiBlast_PDB
79.14
29%
-50
- C2 -
-
1M66
2
GPDA_LEIME
A:
[17-350]
---------------------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
------
I
-
A
Y
A
K
E
K
Q
V
P
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
R
-----
A
V
--
A
E
G
V
A
T
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
----------
4
PsiBlast_PDB
78.92
29%
-52
- C2 -
-
1EVZ
2
GPDA_LEIME
A:
[17-350]
---------------------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
------
I
-
A
Y
A
K
E
K
Q
V
P
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
R
-----
A
V
--
A
E
G
V
A
T
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
----------
3
PsiBlast_PDB
78.91
29%
-51
- C2 -
-
1EVY
1
GPDA_LEIME
A:
[17-350]
---------------------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
------
I
-
A
Y
A
K
E
K
Q
V
P
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
R
-----
A
V
--
A
E
G
V
A
T
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
----------
9
PsiBlast_PDB
78.43
29%
-51
- C2 -
-
1N1G
3
GPDA_LEIME
A:
[17-350]
---------------------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
------
I
-
A
Y
A
K
E
K
Q
V
P
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
R
-----
A
V
--
A
E
G
V
A
T
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
----------
5
PsiBlast_PDB
78.38
29%
-51
- C2 -
-
1JDJ
2
GPDA_LEIME
A:
[17-350]
---------------------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
------
I
-
A
Y
A
K
E
K
Q
V
P
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
R
-----
A
V
--
A
E
G
V
A
T
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
----------
56
HHSearch
78.30
28%
-41
- C2 -
-
1N1E
1
GPDA_LEIME
B:
[9-356]
-------------
K
D
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
IAYAKE
K
-
Q
V
P
------
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
R
T
S
--
K
A
V
AE
G
V
A
T
--
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
L
F
----
57
HHSearch
78.24
28%
-46
- C2 -
-
1EVY
1
GPDA_LEIME
A:
[9-356]
-------------
K
D
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
I
A
Y
A
K
E
K
-
Q
V
P
------
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
R
-----
A
V
A
E
G
V
A
T
--
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
L
F
----
7
PsiBlast_PDB
78.05
29%
-54
- C2 -
-
1M67
2
GPDA_LEIME
A:
[17-350]
---------------------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
------
I
-
A
Y
A
K
E
K
Q
V
P
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
R
-----
A
V
--
A
E
G
V
A
T
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
----------
8
PsiBlast_PDB
78.00
29%
-44
- C2 -
-
1N1E
1
GPDA_LEIME
A:
[17-350]
---------------------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
---------
V
C
V
W
H
M
N
E
-----
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
G
N
L
------
I
-
A
Y
A
K
E
K
Q
V
P
V
-
L
V
C
-
T
K
G
I
E
--
R
--
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
--------
S
A
D
I
---------
N
V
A
R
R
L
Q
R
I
M
-
S
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
---
A
A
L
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
--------------
K
-----
K
L
G
-----------
K
G
----
L
P
I
E
E
I
Q
R
T
S
--
K
A
V
--
A
E
G
V
A
T
A
D
P
L
M
R
--
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
----------
2
PsiBlast_PDB
77.73
35%
-113
- C2 -
-
1Z82
7
?
A:
[16-325]
---------------------
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
E
N
-------
G
E
--------
E
---------
V
I
L
W
A
R
R
K
-----
E
I
-----
V
D
L
I
N
V
S
H
T
S
P
-
Y
V
E
E
S
K
I
--
T
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
E
H
L
L
R
L
P
--
V
------
K
-
P
S
M
------
V
-
L
N
L
-
S
K
G
I
E
--
I
--
K
T
G
--
K
R
V
S
E
I
V
-
E
E
I
L
G
C
P
Y
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
--------
G
E
N
S
------------
K
E
L
Q
K
R
I
-
S
T
E
--
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
A
R
F
G
---
M
F
F
G
A
--
D
Q
K
T
F
M
-
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
-
F
G
--------------
E
-----
L
I
A
-----------
R
G
FN
P
L
K
L
L
E
S
S
N
------
Q
V
--
V
E
G
A
F
T
V
K
A
V
M
K
--
I
A
K
E
N
K
I
--
D
--
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
----------------
60
HHSearch
75.19
27%
-
- C2 -
-
4FGW
-
GPD1_YEAST
B:
[33-385]
------------------
K
P
F
K
V
T
V
I
G
S
G
N
W
G
T
T
I
A
K
V
V
A
E
N
-------
C
K
GYPEVFAP
I
---------
V
Q
M
W
V
F
E
E
-----
E
I
NGEKL
T
E
I
I
N
T
R
H
Q
N
V
K
Y
L
P
G
I
T
L
P
D
N
L
V
A
N
P
D
L
I
D
S
V
K
D
V
D
I
I
V
F
N
I
P
H
Q
F
L
P
R
I
C
S
Q
L
K
G
H
V
------
D
S
H
V
R
------
A
-
I
S
C
-
L
K
G
F
E
--
V
--
G
A
K
GV
Q
L
L
S
S
Y
I
T
E
E
L
G
-
I
Q
C
G
A
L
S
G
A
N
I
A
T
E
V
A
Q
E
H
W
S
E
T
T
V
A
--------
Y
H
I
P
KDFRGEGKD
V
D
H
K
V
L
K
A
L
F
-
H
R
P
--
Y
F
H
V
S
V
I
E
D
V
A
G
I
S
I
C
G
A
L
K
N
V
V
A
L
G
C
G
F
V
E
G
L
G
W
G
N
N
A
S
A
A
I
Q
R
V
G
L
G
E
I
I
R
F
G
---
Q
M
F
F
P
ES
R
E
E
T
Y
Y
Q
E
S
A
G
V
A
D
L
I
T
T
C
A
G
--
G
R
N
V
K
-
V
A
RLMATSGKDAWECE
K
-----
E
L
L
-----------
N
G
----
Q
S
A
Q
-------------
G
L
I
T
--
C
K
E
V
H
E
--
W
L
E
T
C
G
S
VE
D
--
F
P
L
F
E
A
V
Y
Q
I
V
Y
N
N
Y
P
M
K
N
L
P
D
M
I
E
E
----------------
10
PsiBlast_PDB
73.75
31%
-6
- C2 -
-
2PLA
1
GPD1L_HUMAN
A:
[6-336]
--------------------
L
K
V
C
I
V
G
S
G
N
W
G
S
A
V
A
K
I
I
G
N
N
V
K
K
LQKF
A
S
--------
T
---------
V
K
M
W
V
F
E
E
T
V
NGR
K
L
-----
T
D
I
I
N
N
D
H
E
N
V
K
Y
L
P
G
H
K
L
P
E
N
V
V
A
M
S
N
L
S
E
A
V
Q
D
A
D
L
L
V
F
V
I
P
H
Q
F
I
H
R
I
C
D
E
I
T
G
R
V
------
P
-
K
K
A
------
L
G
I
T
L
-
I
K
G
I
D
--
E
G
P
E
G
L
--
K
L
I
S
D
I
I
R
E
K
M
G
-
I
D
I
S
V
L
M
G
A
N
I
A
N
E
V
A
A
E
K
F
C
E
T
T
I
G
--------
S
K
V
M
---------
E
N
G
L
L
F
K
E
L
L
-
Q
T
P
--
N
F
R
I
T
V
V
D
D
A
D
T
V
E
L
C
G
A
L
K
N
I
V
A
V
G
A
G
F
C
D
G
L
R
C
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
I
A
F
A
R
I
F
C
K
G
Q
V
--
S
T
A
T
F
L
-
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
R
-
V
A
--------------
E
-----
A
F
A
R
----------
T
G
----
K
T
I
E
E
L
E
K
E
M
LN
G
Q
K
--
L
Q
G
P
Q
T
S
A
E
V
Y
R
I
L
K
Q
K
G
L
L
D
--
K
--
F
P
L
F
T
A
V
Y
Q
I
C
Y
E
S
R
P
--------------------------
22
PsiBlast_CBE
73.52
31%
-2
- C2 -
-
2PLA
1
GPD1L_HUMAN
B:
[6-336]
--------------------
L
K
V
C
I
V
G
S
G
N
W
G
S
A
V
A
K
I
I
G
N
N
VKKLQKF
A
S
--------
T
---------
V
K
M
W
V
F
E
E
TVNGR
K
L
-----
T
D
I
I
N
N
D
H
E
N
V
K
Y
L
P
G
H
K
L
P
E
N
V
V
A
M
S
N
L
S
E
A
V
Q
D
A
D
L
L
V
F
V
I
P
H
Q
F
I
H
R
I
C
D
E
I
T
G
R
V
------
P
-
K
K
A
------
L
G
I
T
L
-
I
K
G
I
D
--
E
GP
E
G
L
--
K
L
I
S
D
I
I
R
E
K
M
G
-
I
D
I
S
V
L
M
G
A
N
I
A
N
E
V
A
A
E
K
F
C
E
T
T
I
G
--------
S
K
V
M
---------
E
N
G
L
L
F
K
E
L
L
-
Q
T
P
--
N
F
R
I
T
V
V
D
D
A
D
T
V
E
L
C
G
A
L
K
N
I
V
A
V
G
A
G
F
C
D
G
L
R
C
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
I
A
F
A
RIF
C
K
G
Q
V
--
S
T
A
T
F
L
-
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
R
-
V
A
--------------
E
-----
A
F
A
R----------
T
G
----
K
T
I
E
E
L
E
K
E
M
LN
G
Q
K
--
L
Q
G
P
Q
T
S
A
E
V
Y
R
IL
K
Q
K
G
L
L
D
--
K
--
F
P
L
F
T
A
V
Y
Q
I
C
Y
E
S
R
P
--------------------------