@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKC1: (2017-10-26 )
MGLFTLKEVSHYLIENKNMAWSITMCLVAVLLTIFILNLILGLLVHFFDYSEPIWWHALSPYFIALLLFIMVWSVVTELYILRKGGHSLAKQLKARRLVKGESTPEEHAALKITEHLAQTFSLNVPTLYVLPDEVGVNALTAGFHSNDIVIILTWGALQNLDELELYGLLGHEFNQILSGEAVENTKLKILYSGLTTFSQWGSKLAKQGFKRYSPGYKHKFETVFVAVGGVIWLAGSLGVLITRFIKYLTLSGRTFRNDQKTMRLLKNSTNAQTLLRIYVHHSGSQIHSAYSESIAHMCFANSLSPQSWMNIHPSIRERIYELNPTLLQDLQLENLKKLRNRPLFILFHVLEESETEIYTPWSSPQPLPLLRLSPISFALNDAIKPLSSDIRRNKKRPELIQRALQTATGSREVMVAILMIRQYREFIPQDAPVSHAIVDALLNLDGRIHIQIFHDACKNIGHMPASIARQFLTKLALIIQEDGEIGLLDALLLERVKYELNLMPLHLPTAFEEVKPQIVRLIDALLHVQQINSPNQLEVRKRILRSLLNPDEMHIYDEISDEPLDLAEILNDIAGLLLRDRLSILAIVEMCLWSDRIITQDELDVLELLYWRFGFESDEIVEQMQKKNSVMII
Atome Classification :
(20 SA)
-----------------------------------------------.........---------10...--..-...20.---------------.......30...--.-----...-------.40........50------.----........60........70..----.---.....80........90.--....--.------..100.........110-.......120..----.-----------------....------.130------..---.....140..-..---...150--....----...160..-----.-....170-------------........180-----.........190..-------.....200...---....210-....-.....220.-----..----......230---------..------..-.....240.......250.--..---....-260......--------.270......-.---..280.......290.......---------300.-.-.....310....-----...320..---.....330......--...--------------340.....-..350...-....360......---.370.......-380----------........390------..-.....-----.400---------......--.410..------.-----.---...420-----------------------......-..430.-------.--.....440...--....450---------.........460...-------....470.....--------..480.......490.......500.......510.....----------------..520..-.----....530.----.-....--..540....-------------...550---....--...560..--------...-..570.......580..-.......590-.---......600.-----......610......---------.620.......630..----------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------MG
L
F
T
L
K
E
V
---------
S
H
Y
L
I--EN-KNM
A
W
S
---------------
I
T
M
C
L
V
A
V
L
L
T
I
--
F
-----
I
L
N
-------
L
I
L
G
L
L
V
H
F
FDY-------S----E
P
I
W
W
HAL
S
P
Y
F
I
A
L
L
L
F
I
M
V
W
----
S
---
V
V
T
E
L
Y
I
L
RKG
G
H
S
L
A
K
Q
--
L
K
A
R
--
R
------LVK--GEST
P
E
E
H
A
A
L
K
-
I
T
E
H
L
A
Q
T
-FSL----N-----------------V
P
T
L
------
Y
V
LP------DE---VG
V
N
A
L
TAGF-HS---N
D
I
V
I
I
--
L
T
W
G
----ALQ
N
L
D
E
L
-----
E
-
L
Y
G
L
L
G
--------------
H
E
F
N
Q
I
LSG-------EAVEN
T
K
L
K
I
L
YSG-------
L
T
T
F
S
Q
W
G
S
K
L
---
A
K
Q
G
F
---
K
RYS-PGYK
H
K
--
F
-----
E
T
----
V
F
V
AVGG-----------
V
I
------
W
L-AG
S
L
G
V
L
I
T
R
F
I
K
Y
L
TLSG--RT---FR
N
D
-
Q
K
T
M
R
L
L
KN--------ST--
N
A
Q
T
L
L
-
R
---
I
Y
V
HHSG
S
Q
I
H
S
A
Y
S
E
S
I
A
H
M
C
---------
F
ANS-L-SP
Q
S
W
M
NI
H
P
S
I
-----
R
E
R
I
Y
EL
N
---
P
T
L
L
Q
D
--
L
Q
L
E
N
L
--
K
K
L
--------------RNR
P
L
F
I
L
-
F
H
V
LEESE-T
E
I
YTPWSSPQP
L
---
P
L
L
R
LS
P
I
S
F
A
-
L
N
-----------
D
A
I
K
P
L
S
S
D
I
-------
R
R-NKK
R
P
-----
E
L
I
Q
---------
R
A
L
Q
TA--TG
S
R
E
V
------
M
-----
V
---
A
I
L
M
I
------------------------
R
Q
Y
R
E
F-IPQDAP-------
V
--
S
H
A
I
V
D
A
L
LNL--D
G
R
I
H
-----------
I
Q
I
F
H
D
A
C
K
NIGHM
P
-------
A
S
I
A
R
Q
F
L
T
K
L
A
--------
L
I
IQEDGEI
G
L
L
D
A
L
L
L
E
R
V
K
Y
E
L
N
L
M
PLHLP
T
A
F
E
E
V
K
P
----------------
Q
I
V
R
L
I
D
-
A
----
L
L
H
V
Q
Q-I----N-S
P
N
Q
--
L
E
V
R
K
R
I
L
R
-------------
S
LL
N
P
D
---
E
M
H
I
--
Y
D
EISDEP--------L
D
L
-
A
E
I
L
N
D
I
A
G
L
L
L
R
--
D
R
-
L
S
I
L
A
I
V
E
M
C
-L---WSDRII
T
Q
D
E
-----
L
D
V
L
E
L
L
Y
W
RFGF
E
S
---------
D
E
I
V
E
Q
M
Q
KKNS
V
M
II----------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
54.41
20%
11
- C3 -
-
4BQ2
6
?
A:
[2-747]
-----------------------------------------------------------------
S
H
M
L
F
DF
E
N
-
D
Q
V
P
S
N
---------------
I
H
F
L
N
A
R
A
S
I
E
T
--
Y
-----
T
G
I
NG
E
P
S
K
G
L
K
L
A
M
Q
S
K
Q
H
S
Y
-------
T
G
L
A
I
V
P
E
Q
P
W
D
W
S
E
F
T
S
A
S
L
Y
F
D
I
V
S
V
G
D
H
S
---
T
Q
F
Y
L
D
V
T
D
Q
N
G
A
V
F
T
R
S
--
I
D
I
P
--
V
G
K
M
Q
S
Y
Y
A
K
LS
G
H
D
L
E
V
P
D
S
G
D
V
-
N
D
L
N
L
A
S
G
-
L
R
S
----
N
-----------------
P
P
T
W
TSDDRQ
F
V
W
M
WGVKNL
D
L
---
S
G
I
A
K
I
S
L
S
V
-
Q
S
AM
H
D
K
T
V
I
I
D
N
I
R
I
Q
----
P
N
P
P
Q
D
E
N
-----
F
-
L
V
G
L
V
D
EFGQNAKVDYKGKI
H
S
L
E
E
L
H
A
A
-------
R
D
V
E
L
A
E
L
D
--
G
K
P
-------
M
P
S
R
S
K
F
G
G
W
L
---
A
--
G
P
---
K
L
K
A
-
T
G
Y
F
R
T
--
E
-----
K
I
NG
K
W
M
L
V
D
P
E
G
-----------
Y
P
------
Y
F
-
A
T
--
G
L
D
I
I
R
L
S
N
S
S
T
M
T
G
--
Y
D
---
Y
D
Q
A
-
T
V
A
Q
R
S
A
D
D
--------
V
T
--
P
E
D
S
K
G
-
L
---
M
A
V
S
E
K
S
F
A
T
R
H
L
A
S
P
T
R
A
A
M
F
N
W
L
P
D
YDHP
L
A
N
H
-
Y
-
N
Y
R
R
S
A
H
S
G
P
L
K
-----
R
G
E
A
Y
S
F
Y
---
S
A
N
L
E
R
--
K
Y
G
E
T
Y
PG
S
Y
L
--------------
D
K
W
R
E
V
T
V
-
D
R
M
L
N
W
G
F
-
T
S
L
-
G
N
W
T
D
P
A
Y
Y
---
D
N
N
R
I
P
F
F
A
N
G
W
V
I
-----------
G
D
F
K
T
V
S
S
G
A
-------
D
F
-
W
G
A
M
P
DVFD
P
E
F
K
V
---------
R
A
M
E
T
A
--
R
V
V
S
E
E
------
I
KNSPW
C
---
V
G
V
F
I
------------------------
D
N
E
K
S
F
G
R
P
D
S
D
K
-------
A
--
Q
Y
G
I
P
I
H
T
L
G
R
PS
E
G
V
P
T
-----------
R
Q
A
F
S
K
L
L
K
A
K
Y
K
T
I
-------
A
A
L
N
N
A
W
G
L
K
L
S
S
W
A
E
F
D
L
G
V
D
V
K
A
L
P
V
T
D
T
L
R
A
D
Y
S
M
L
L
S
A
Y
A
D
Q
Y
F
K
V
V
H
G
A
V
E
H
Y
M
P
N
H
L
Y
L
G
ARFPDWGMP
M
E
V
V
K
A
A
A
-
K
----
Y
A
D
V
V
S
-
Y
----
N
-
S
Y
K
E
GL
P
K
Q
K
W
A
F
L
A
-------------
E
L
D
K
P
S
I
I
G
E
F
H
I
G
A
M
D
H
G
S
Y
H
P
GL
I
H
A
AS
Q
A
D
R
-
G
E
M
Y
K
D
Y
M
Q
S
V
I
D
--
N
P
-
Y
F
V
G
A
H
W
F
Q
Y
-
M
DSP
L
T
G
R
A
Y
D
G
E
N
YNVGF
V
D
V
T
D
T
P
Y
Q
E
M
V
D
A
A
---------
K
E
V
N
A
K
I
Y
T
E
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
49.56
19%
-23
- C2 -
-
3UGM
-
PTHX1_XANOP
A:
[169-1048]
-----------------------------KPKVRELVAHIVALSQHP
A
A
L
G
T
V
A
V
T
YQHIITALA
T
H
E
D
I
--
V
G
-
V
G
K
Q
W
S
---------------
G
A
R
A
L
E
A
L
L
T
D
A
--
G
E
L
RGP
P
L
Q
-------
L
D
T
G
Q
L
V
K
I
A
K
R
GG
V
T
A
M
E
A
----
V
H
A
S
R
N
A
L
T
P
L
N
L
T
P
A
Q
V
V
A
I
A
----
S
NNG
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
HG
L
T
P
A
--
Q
------
V
V
A
--
I
A
S
H
D
G
G
K
Q
A
L
E
-
T
M
Q
R
L
L
P
V
-
L
C
Q
----
A
HGLP
P
D
Q
V
V
A
I
A
SNIG
G
K
Q
A
L
------
E
T
V
Q
------
R
L
---
L
P
V
L
C
Q
A
H
G
L
-
T
P
---
D
Q
V
V
A
I
--
A
S
H
G
G
G
K
Q
A
L
E
T
V
Q
R
L
LPVLC
Q
-
A
H
G
L
T
P
--------------
D
Q
V
V
A
I
A
S
H
DG
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
GLT
P
D
Q
V
V
A
I
A
S
N
G
G
G
K
Q
---
A
L
E
T
V
---
Q
R
L
L
-
P
V
L
C
Q
A
--
H
GLT
P
D
Q
V
----
V
A
I
A
S
N
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
------
V
L
-
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
H
D
G
G
K
Q
A
---
L
E
T
V
-
Q
R
L
L
P
V
L
C
Q
--------
T
H
GL
T
P
A
Q
V
V
-
A
---
I
A
S
H
D
G
G
K
Q
A
L
E
T
V
Q
Q
L
L
P
V
L
C
---------
Q
A
H
G
-
L
-
T
P
D
Q
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
A
T
V
Q
R
L
L
---
P
V
L
C
Q
A
HG
L
T
P
D
Q
V
--
V
A
I
A
S
N
GGG
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
-
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
L
---
E
T
V
Q
R
L
L
P
V
L
C
-
Q
A
HGLTQ------
V
Q
V
V
A
I
A
S
N
I
GGKQA
L
E
T
V
-
Q
R
L
L
P
-----
V
L
C
Q
A
H
G
L
T
P
A
Q
V
V
A
I
A
S
H
--
D
G
G
K
Q
A
------
L
-----
E
---
T
V
Q
R
L
L
P
V
L
C
Q
AHGLT
P
D
Q
V
V
A
IASNGG
G
K
Q
A
L
E
T
-
V
Q
R
L
L
P
-------
G
LT
Q
E
Q
V
V
A
I
A
S
N
N
--
G
G
K
Q
A
-----------
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
GLT
P
D
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
--------
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
A
Q
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
E
T
V
Q
R
----------------
L
L
P
V
L
C
Q
-
D
HGLT
L
A
Q
V
V
A
-
I
A
SNI
G
-
G
K
Q
A
--
L
E
T
V
Q
R
L
L
P
-------------
V
L
C
Q
G
L
---
T
Q
D
Q
--
V
V
A
I
A
S
N
I
G
G
------
K
Q
A
-
L
E
T
V
Q
R
L
L
P
V
L
C
Q
--
D
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
---
I
G
G
K
Q
A
L
E
T
V
-----
Q
R
L
L
P
V
L
C
Q
D
H
G
L
T
L
---------
D
Q
V
V
A
I
A
S
N
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
DHGLTPDQVVAIASNSG------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
46.25
28%
-145
- C4 -
-
3CQB
2
HTPX_VIBPA
A:
[25-103]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
W
L
L
E
-
T
V
G
R
Q
A
Q
Q
-
A
G
I
----
G
-----------------
M
P
T
V
------
A
I
Y
-------
D
S
---
A
D
I
N
A
F
A
T
G
A
-
K
-----
D
S
L
V
A
--
V
S
T
G
----
L
L
H
N
M
T
R
D
-----
E
-
A
E
A
V
L
A
--------------
H
E
V
S
H
I
A
N
G
-------
D
M
V
T
M
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
43.97
18%
-194
- C4 -
-
2H5N
-
?
D:
[11-125]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
F
S
-------
G
Q
E
L
T
A
I
I
K
M
A
K
--------
S
M
V
M
A
D
G
K
I
K
P
A
E
I
A
V
M
T
R
E
F
M
R
F
G
----
I
L
Q
-------
D
----------------
Q
V
D
L
L
L
K
--------------------------------
A
S
D
-------------
S
I
-------------------
E
A
--------
S
Q
A
-
V
---
A
L
I
A
R
M
D
E
E
--
R
K
-
K
Y
V
A
S
Y
L
G
V
I
-
M
---
A
S
D
G
D
I
D
D
N
E
-----
L
A
L
W
T
L
I
S
T
L
C
G
L
P
T
---------
M
T
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
41.97
17%
-28
- C3 -
-
4ZFV
2
?
A:
[10-445]
--------------------------------------------------------------------------------
N
---------------
V
L
D
F
T
V
L
G
L
N
S
G
--
T
-----
S
M
D
-------
G
I
D
C
A
L
C
H
F
Y
Q
K
-------
T
----
P
D
------
A
P
----------------------
M
E
F
E
L
L
E
Y
G
E
V
P
L
A
Q
P
--
I
K
Q
R
V
M
R
------
M
I
L
--
E
D
T
T
S
-
P
S
E
L
S
E
-
V
N
V
I
L
G
E
H
-
F
A
D
----
A
-----------------
V
R
Q
F
------
A
A
E
R
-------------------
N
V
-
D
L
---
S
T
I
D
A
I
--
A
S
H
G
-----------
Q
-----
T
-
I
W
L
L
S
M
--------------
P
E
E
G
Q
V
K
S
A
-------
L
T
M
A
E
G
A
I
L
A
S
R
T
G
-------
I
T
S
I
T
D
F
R
I
S
D
---
Q
A
------------------------------------------------------------
A
G
R
Q
G
A
P
L
I
A
F
F
D
A
L
L
L
-----------------------------------
H
H
P
T
K
L
-
R
---
A
C
Q
N
I
G
G
----------
I
A
N
V
C
---------
F
I
P
P
---------
D
V
D
G
R
R
-----
T
D
E
Y
Y
D
F
D
TGP
G
N
V
F
I
D
--
A
V
V
R
H
F
--
T
N
G
--------------
E
Q
-----------
E
Y
D
K
-
D
G
A
M
G
K
R
G
K
V
D
Q
E
---
L
V
D
D
F
L
K
M
P
Y
F
-
Q
L
-----------
D
P
P
K
T
T
G
R
E
V
-------
F
R
-
D
T
L
A
H
-----
D
L
I
R
---------
R
A
E
A
K
G
--
L
S
P
D
D
I
V
A
T
T
T
R
I
-----
T
---
A
Q
A
I
V
------------------------
D
H
Y
R
R
Y
-
A
P
S
Q
---------------------
E
I
--
D
---
E
-----------
I
F
M
C
G
G
G
A
Y
N
-
P
N
I
V
-------
E
F
I
Q
Q
S
Y
P
N
T
K
I
--------
M
M
L
D
E
A
G
-----------------------
V
P
A
G
A
K
E
A
I
T
----------------
F
A
W
Q
G
M
E
-
A
----
L
V
G
-
R
S
-
I
----
P
-
V
P
T
R
--
V
E
T
R
Q
H
Y
V
L
-------------
G
K
V
S
P
G
-----
L
N
--
Y
R
S
V
M
K
K
G
--------
M
A
F
-
G
G
D
A
Q
Q
L
P
-------------------------
W
V
S
E
M
I
V
K
K
K
-----
G
K
V
I
T
N
-
N
W
A
G
S
H
H
H
---------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
41.78
18%
-186
- C4 -
-
2H5N
-
?
A:
[8-125]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
I
M
T
F
S
-------
G
Q
E
L
T
A
I
I
K
M
A
K
--------
S
M
V
M
A
D
G
K
I
K
P
A
E
I
A
V
M
T
R
E
F
M
R
F
G
----
I
L
Q
-------
D
----------------
Q
V
D
L
L
L
K
--------------------------------
A
S
D
-------------
S
I
-------------------
E
A
--------
S
Q
A
-
V
---
A
L
I
A
R
M
D
E
E
--
R
K
-
K
Y
V
A
S
Y
L
G
V
I
-
M
---
A
S
D
G
D
I
D
D
N
E
-----
L
A
L
W
T
L
I
S
T
L
C
G
L
P
T
---------
M
T
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
41.02
21%
-107
- C4 -
-
3CQB
3
HTPX_VIBPA
A:
[2-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
S
K
G
M
A
L
R
S
--
V
G
G
M
--
V
------
I
E
S
--
P
-
R
N
E
T
E
H
W
L
L
E
-
T
V
G
R
Q
A
Q
Q
-
A
G
I
----
G
-----------------
M
P
T
V
------
A
I
Y
D
------
S
A
----
D
I
N
A
F
A
T
G
A
-
K
-----
D
S
L
V
A
--
V
S
T
G
----
L
L
H
N
M
T
R
D
-----
E
-
A
E
A
V
L
A
--------------
H
E
V
S
H
I
A
N
G
-------
D
M
V
T
M
T
L
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
37.45
14%
-81
- C4 -
-
4JIX
5
Y123_METJA
A:
[9-79]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
D
I
K
D
-
I
V
N
E
I
L
I
S
-
L
N
I
----
N
E
----------------
S
I
N
I
------
E
I
K
P
------
M
K
----
Q
-
K
I
A
S
F
S
---
F
---
K
T
K
T
L
R
--
L
N
K
Y
----
V
V
E
N
F
D
E
E
-----
L
-
L
H
Y
I
I
L
--------------
H
E
L
I
H
F
K
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
37.33
14%
-97
- C4 -
-
4JIX
2
Y123_METJA
B:
[9-79]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
D
I
K
D
-
I
V
N
E
I
L
I
S
-
L
N
I
----
N
E
----------------
S
I
N
I
------
E
I
K
P
------
M
K
----
Q
-
K
I
A
S
F
S
---
F
---
K
T
K
T
L
R
--
L
N
K
Y
----
V
V
E
N
F
D
E
E
-----
L
-
L
H
Y
I
I
L
--------------
H
E
L
I
H
F
K
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
37.29
19%
-260
- C4 -
-
2H5N
-
?
A:
[10-61]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
M
T
F
S
G
Q
--
E
L
-
T
A
I
I
K
M
A
K
S
M
-
V
---
M
A
D
G
K
I
K
P
A
E
-----
I
A
V
M
T
R
E
F
M
R
F
G
I
L
Q
---------
D
Q
V
D
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
36.40
15%
-50
- C4 -
-
4QHI
2
Y1213_METJA
B:
[4-81]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
I
L
N
E
-
I
L
S
N
T
I
N
E
-
L
N
L
NDKK
A
-----------------
N
I
K
I
------
K
I
K
P
------
L
K
------
W
K
I
A
S
-
I
-
S
L
---
T
N
K
T
I
Y
--
I
N
K
N
----
I
L
P
Y
L
S
D
E
-----
E
-
I
R
F
I
L
A
--------------
H
E
L
L
H
L
K
Y
G
K------
Y
H
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
36.14
16%
-17
- C4 -
-
4QHJ
-
Y1213_METJA
A:
[4-77]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
I
L
N
E
-
I
L
S
N
T
I
N
E
-
L
N
L
NDKK
A
-----------------
N
I
K
I
------
K
I
K
P
------
L
K
----
R
----
K
I
A
S
I
S
L
---
T
N
K
T
I
Y
--
I
N
K
N
----
I
L
P
Y
L
S
D
E
-----
E
-
I
R
F
I
L
A
--------------
H
E
L
L
H
L
K
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
34.85
19%
-92
- C4 -
-
4JIU
-
?
A:
[1-69]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
E
D
-
L
L
E
H
A
K
D
I
-
L
G
Y
----
Q
R----------------
P
V
K
V
------
R
I
R
P
------
L
K
-----
M
S
I
A
R
V
S
F
------
K
Y
G
T
I
T
--
L
D
P
A
----
V
-
L
N
L
E
E
E
-----
E
-
M
F
Y
I
L
I
--------------
H
E
L
A
H
L
K
A
E
-------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
34.74
19%
-236
- C4 -
-
2H5N
-
?
D:
[11-61]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
F
S
G
Q
--
E
L
-
T
A
I
I
K
M
A
K
S
M
-
V
---
M
A
D
G
K
I
K
P
A
E
-----
I
A
V
M
T
R
E
F
M
R
F
G
I
L
Q
---------
D
Q
V
D
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
33.64
17%
-49
- C4 -
-
4IL3
-
?
B:
[229-446]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
E
L
K
K
-
S
I
E
S
L
A
D
R
-
V
G
F
----
P
-----------------
L
D
K
I
------
F
V
I
D
------
G
S
KRS
S
H
S
N
A
Y
F
T
G
L
-
P
F
---
T
S
K
R
I
V
--
L
F
D
T
----
L
V
N
S
N
S
T
D
-----
E
-
I
T
A
V
L
A
--------------
H
E
I
G
H
W
Q
K
N
-------
H
I
V
N
M
V
I
F
S
Q
L
H
T
F
-------
L
I
F
-
S
L
F
T
S
I
Y
---
R
N
S
S
F
Y
N
T
F
G
F
F
V
E
K
S
S
S
G
FV
D
P
V
I
TK
E
F
----
P
-
I
I
I
G
F
-----------
M
L
------
F
N
D
L
L
T
P
L
E
C
A
M
Q
F
I
M
S
L
I
S
R
T
--
H
E
---
Y
Q
A
D
-
A
Y
A
K
K
L
G
-
Y
--------
K
Q
--
N
L
C
R
A
L
I
D
---
L
Q
I
K
N
L
S
T
M
--------
N
V
D
P
L
-----------------
Y
S
S
Y
H
Y
S
H
P
T
L
-----
A
E
R
L
T
A
L
D
---
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
32.15
16%
-48
- C3 -
-
4ID9
2
?
A:
[21-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
------
L
V
-
T
G
S
A
G
R
V
G
R
A
V
V
A
A
L
R
T
Q
G
--
R
T
----------
V
R
G
F
D
L
R
--------
P
S
--
G
T
G
G
E
E
-
V
---
V
G
S
L
E
D
G
Q
A
L
S
D
A
I
M
G
V
S
A
V
L
H
---------
L
G
--------
A
F
M
S
W
A
P
A
D
-----
R
D
R
M
F
A
V
N
---
V
E
G
T
R
R
--
L
-
L
D
A
A
--
S
A
A
--------------
G
V
R
R
F
V
F
A
-
S
S
-------
G
E
V
Y
-
P
E
N
R
P
E
F
L
---
P
V
T
E
D
H
P
---------------------
L
C
P
N
S
P
Y
-------
G
L
-
T
K
L
L
G
-----
E
E
L
V
---------
R
F
H
Q
R
S
--
G
A
M
E
T
V
------
I
-----
L
---
R
F
S
H
T
------------------------
Q
D
A
T
E
L
-
L
D
E
D
S
F
F
S
G
P
R
F
F
L
--
R
P
R
I
H
Q
Q
Q
N
F
G
--
N
A
A
I
A
-----------
E
L
L
Q
S
R
D
I
G
E
P
S
H
I
L
-------
A
R
N
E
N
G
R
P
F
R
M
H
--------
I
T
D
T
R
D
M
V
A
G
I
L
L
A
L
D
H
P
E
A
A
G
G
T
F
N
L
G
A
D
E
P
A
D
F
A
A
L
L
P
----------------
K
I
A
A
L
T
G
L
P
----
I
V
T
V
D
F
-
P
----
G
-
D
G
V
Y
--
Y
H
T
S
N
E
R
I
R
-------------
N
T
L
G
F
E
---
A
E
W
T
--
M
D
R
M
L
E
E
A
--------
A
T
A
-
R
R
Q
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
32.15
10%
-34
- C3 -
-
1Z3H
-
CSE1_YEAST
A:
[2-959]
S
D
L
E
T
V
A
K
F
L
A
E
S
V
IAST
A
K
T
S
E
R
N
L
R
Q
L
ETQDG
F
G
L
T
L
L
H
V
I
A
STN
L
P
L
S
T
R
L
A
G
---------
A
L
F
F
K
--
N
F
-
I
K
R
K
W
V
DENGNHLLP
A
N
N
V
E
L
I
K
K
E
I
V
P
L
M
I
S
L
P
N
N
-----
L
Q
V
-------
Q
I
G
E
A
I
S
S
I
A
D
S
-------
D
----
F
P
D
R
W
P
T
L
L
S
D
L
A
S
R
L
S
N
--------
D
---
D
M
V
T
N
K
G
V
L
T
V
A
H
S
I
F
K
R
--
W
R
P
L
--
F
------
R
S
D
--
E
L
F
L
E
I
K
L
V
L
D
V
-
F
T
A
P
F
L
N
L
-
L
K
T
----
V
-----------------
D
E
Q
I
------
T
A
N
E
------
N
N
---
K
A
S
L
N
I
L
F
D
V
-
L
L
---
V
L
I
K
L
Y
--
Y
D
F
N
----
C
Q
D
I
P
E
F
F
-----
E
D
N
I
Q
V
G
M
--------------
G
I
F
H
K
Y
L
S
Y
SN-----
P
L
L
E
D
P
D
E
T
E
H
A
S
V
-------
L
I
K
V
K
S
S
I
Q
E
L
---
V
Q
L
Y
T
---
T
R
Y
E
-
D
V
F
G
P
M
--
I
-----
N
E
----
F
I
Q
I
T
W
N
-----------
L
L
T
S
ISNQ
P
K
-
Y
D
I
L
V
S
K
S
L
S
F
L
T
A
V
T
R
I
P
--
K
Y
F
E
I
F
N
N
E
-
S
A
M
N
N
I
T
E
Q
IILPNVTL
R
E
--
E
D
V
E
L
F
-
E
D
D
P
I
E
Y
I
R
R
D
L
E
G
S
D
T
D
T
R
R
R
A
C
T
D
---------
F
L
K
E
-
L
-
K
E
K
N
E
V
L
V
T
N
I
F
-----
L
A
H
M
K
G
F
V
---
D
Q
Y
M
S
D
--
P
S
K
N
W
K
--
F
K
D
--------------
L
Y
I
Y
L
F
T
A
-
L
A
I
N
G
N
I
T
-
N
A
G
V
S
S
T
N
N
L
L
N
V
---
V
D
F
F
T
K
E
I
A
P
D
-
L
T
SNNIPH
I
I
L
R
V
D
A
I
K
Y
I
Y
T
F
R
-------
N
Q
L
T
K
A
Q
L
-----
I
E
L
M
---------
P
I
L
A
T
F
--
L
Q
T
D
E
Y
------
V
-----
V
Y
T
Y
A
A
I
T
I
------------------------
E
K
I
L
T
I
-
R
E
S
S
N
S
-------
T
--
E
I
L
L
K
N
L
I
A
L
I
--
L
K
H
G
S
S
P
E
K
L
A
EN
E
F
L
M
R
S
I
F
R
V
L
Q
T
S
E
D
S
I
-------
Q
P
L
F
P
Q
L
L
A
Q
F
I
--------
E
I
V
T
I
M
A
K
N
P
S
N
P
R
F
T
H
Y
T
F
E
S
I
G
A
I
L
N
Y
T
Q
R
Q
N
L
P
L
L
V
D
----------------
S
M
M
P
T
F
L
-
T
----
V
F
S
E
D
I
-
Q
----
E
F
I
P
Y
V
--
F
Q
I
I
A
F
V
V
E
Q
SATIPESI
K
P
L
A
Q
P
L
L
A
P
---
N
V
W
E
--
L
K
G
N
I
P
A
V
--------
T
R
L
-
L
K
S
F
I
K
T
D
S
S
I
F
P
--
D
L
-
V
P
V
L
G
I
F
Q
R
L
-
I
----
A
S
K
A
Y
E
V
H
G
-----
F
D
L
L
E
H
I
M
L
L
I
D
M
N
R
LRPY
I
K
Q
I
A
V
L
L
L
Q
R
L
Q
N
S
K
T
E
R
Y
V
K
K
L
T
V
F
F
G
L
I
S
N
K
LG
S
D
F
L
I
H
F
I
D
E
V
QDG
L
F
Q
Q
I
W
G
N
FIITTLPTIGN
L
L
D
R
K
I
A
L
I
G
V
L
N
M
V
I
NGQFFQSKYPTL
I
S
S
T
M
N
S
I
I
E
T
A
S
SQSGSHFSKLVSISEKPFDPLPEIDVNNG
V
R
L
Y
V
A
E
A
L
N
K
Y
N
A
I
S
GNT
F
L
N
T
I
L
PQLT
Q
E
N
Q
V
K
L
N
Q
L
L
V
G
22
HHSearch
32.00
19%
-249
- C4 -
-
3DTE
-
IRRE_DEIDV
A:
[61-101]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
H
V
I
L
--
I
N
S
Q
--------
V
R
P
E
-----
R
-
Q
R
F
T
L
A
--------------
H
E
I
S
H
A
L
L
L
-------
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
31.55
19%
-221
* C4 *
-
3DTK
-
IRRE_DEIDV
A:
[81-121]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
H
V
I
L
--
I
N
S
Q
--------
V
R
P
E
-----
R
-
Q
R
F
T
L
A
--------------
H
E
I
S
H
A
L
L
L
-------
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
29.69
14%
-8
- C3 -
-
4JW1
1
?
A:
[18-625]
--------------------------------------------VRF
A
G
F
Y
K
D
N
D
G
---------
G
K
F
F
I
--
K
K
P
G
D
P
R
E
L
---------------
F
T
E
L
F
A
G
L
L
L
K
E
--
F
M
----
K
R
G
-------
L
I
----------------------
D
E
S
Y
F
P
S
L
----------------------
I
C
A
D
V
I
Q
F
E
D
K
S
Y
G
L
I
Q
P
--
L
V
S
F
--
D
------
E
L
H
--
K
V
I
G
Q
N
K
Y
F
G
L
S
M
A
L
------
M
F
S
L
----
L
-----------------
L
G
A
H
------
S
V
------------------------
H
S
---
G
N
I
V
V
L
--
N
------------------------------------------------
G
E
E
-------
K
E
K
S
K
Q
F
G
R
I
----------------
D
W
G
D
R
Y
FAH
P
N
N
N
D
---
N
L
Y
A
-
K
D
Y
--------------------------------------------------------
F
L
N
Y
K
K
I
N
G
-------
L
F
P
A
M
A
E
K
A
R
Q
L
Q
S
--------
K
L
--
N
P
E
L
L
V
-
K
---
I
-
V
T
S
A
L
K
N
I
P
A
D
L
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D
E
K
T
K
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Q
---------
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A
A
Y
M
C
M
D
S
F
K
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A
T
F
G
T
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-----
N
C
K
D
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A
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--
A
T
L
L
E
N
--
R
-
L
G
K
I
--
A
V
L
--------------
K
L
K
P
L
T
L
L
M
T
S
--
S
T
S
F
-
S
E
T
I
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W
A
D
I
L
K
T
T
DM
E
K
F
S
F
D
S
N
P
I
N
-
L
L
-----------
E
L
V
K
Q
F
N
L
Y
V
-------
D
E
-
L
A
I
T
C
-----
E
A
N
N
---------
V
W
L
F
A
L
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N
S
G
G
E
A
------
I
-----
H
---
G
H
A
F
V
------------------------
P
Y
Y
K
------
E
S
I
-------
V
--
L
R
R
L
F
T
V
D
P
N
T
--
F
N
L
S
R
-----------
F
A
A
F
E
G
P
C
Q
L
Y
C
K
E
H
-------
K
D
---
S
A
W
V
K
I
Q
--------
T
L
L
T
L
G
N
G
I
-
I
N
T
L
K
I
I
K
Q
A
Q
------
A
F
G
I
D
E
A
V
T
E
N
L
K
----------------
A
L
K
E
Q
F
I
-
A
----
F
Q
L
A
E
A
D
I
----
K
-
E
P
N
------------------------------
K
---
E
S
E
F
--
F
Y
P
I
D
E
K
A
--------
L
A
K
M
N
--
G
Y
Q
L
A
T
I
C
L
E
E
L
N
S
-
P
K
P
S
P
L
I
E
R
I
-
L
---
S
N
K
K
F
W
K
R
I
N
-----
S
A
F
E
S
G
V
F
K
G
R
T
D
D
P
---------
A
G
K
I
A
K
I
R
E
W
H
Q
L
L
Q
I
S---------------------------------------------------------------------------------------------------------------------------------------------------------------