@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKD0: (2017-10-26 )
MFEKIRSDMNPHQAYRIKKLQCQLDMAESYEEWKSFALKLDEETGAQEWKFDNSSPYFDAELISYRYTLLKRYRQQHRTLDLIYLLKEGLTYDIANIGHPMLFAATHVGTKKLIEDYIEEVSQSLAYIASSECITFQRKEKIEFFENCEKAYGQPALMFSGGATLGLFHTGVCKALIEQDLMPKVLSGSSAGAIMTGMLGISASEDIQNLLNGEQFFSDAFHFRKLRELIKGNGGIADVHYLKKFLIENLGDLTFEEAFKKSGLNINVAVAPYDATENPRIMNAIMTPNVLVWSAVLASCAVPVLFPPVRLTSKRYDGEHTPYMANTKWVDGSVRSDFPQERMARLYNLNYTIASQVNPHVVPFMQDDARRFRKDVLSWPERILRRQGKVLSMGLMDFTRQRLGAISPVRRLLDHGYGVVGQRYYGDVNIIAKYSLKHYAYTLQNPRPHLFKRLQREGERATWPKISSIETHARIGKTIQHCLEVLRFEEKKQQPESYYAEA
Atome Classification :
(20 SA)
-----------------------------------------------------......-..--.10........----------20..-------.-....-------------.30.--------.......40-------------......---------..50...-.....-60...-----.....70..----..----------....-80........90........--100---.......-.110-------.......120........----130..---....-----------------.140.......150..-------.....160----------------.....----..-------170......------------------.-------------180----------.--.--..-.....190.....-..200------------.-.--------.....----..210......--.220.--------.------------..---------------------------...-------------------------230..---....-----.240--..-...-...250------------.----.-----....-.--.260--------.........270.......280.....-----..290------------------.......300.--------------------.....--.310........320....-----------------------...330....-...340...-....350.....---..360-------.........370.......380.......----.390....-----.....400...-..------------------..410--------...---..-...420.-....-..430....--...440......------------.450........460........--470....----..-.480.......490..--.---....500----------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------M
F
E
K
I
R
-SD--MN
P
H
Q
A
Y
R
I
K
K
----------
L
Q
C
Q
-------L-
D
M
A
E
-------------
S
Y
E
E
--------
W
K
S
F
A
L
K
LD-------------EETGAQ---------EWKFDNS-SPYF
D
-
A
E
L
I
S
-----
Y
R
Y
T
L
L
K
R
Y
----
R
Q
----------
Q
HR
T
-
L
D
L
I
Y
L
L
K
EGLT
Y
D
I
A
NIGH--P
M
----
L
F
A
A
THV-
G
T
K
K
-------
L
I
E
D
Y
I
E
E
-
V
S
Q
S
L
A
Y
I
A----SSE
C
I
---
T
F
Q
R
-----------------
K
E
K
I
E
F
F
E
N
C
E
K
A
YGQ-------
P
A
L
M
FSGG----------------
A
T
L
G
L
----
F
H
-------
T
G
V
C
K
A
L
I
E
------------------
Q
-------------
D
------------
L
--
M
--
P
K
-
V
LSGSS
A
G
A
I
M
T
G
-
M
LG--------------I-S--------
A
S
E
D
I
----
Q
N
L
L
N
G
E
Q
F
F
S
--
D
A
F
H
F
--------
R
------------
K
L
---------------------------
R
E
L
-------------------------
I
KGNG---GI
A
D
-----
V
H
Y
---
L
K
-
K
F
L
-
I
E
N
LG-------------D----
L
-----
T
F
E
E
-
A
--
F
K
----------KSG
L
N
I
N
V
A
VAPYDATENP
R
I
M
N
A
IMT-----P
N
V
L
V
------------------
W
S
A
V
L
A
SCAV
P
--------------------
V
LFPP--VR-
L
T
SKRYDGEHTPYMAN-----------------------TKWVDGSVRS-D
F
P
Q
E
R
M
A
R
-
L
YNL
N
Y
T
I
ASQV---NP
H
---------
V
V
P
F
M
Q
D
D
A
R
R
F
R
K
D
V
L
S
W
P
E
-
R
I
L
R
RQG----
K
V
--
L
S
M
G
-----
L
M
D
F
T
R
Q
R
LG
A
-
I
S
------------------
P
V
R
R
---------
L
L
D
---HG-YGVVG
Q
R
-YYG
D
-
V
N
I
I
A
K
YSL--
K
H
Y
A
Y
TLQNP
R
P
------------
H
L
F
-
K
R
L
Q
REGER-ATWPKIS
S
I
--
E
T
H
A
R
I
G
----
K
T
-
I
Q
H
C
L
E
V
L
R
F
E
E
K
KQQ--
P
---
E
S
YYAEA----------------------------------------------------------
37
Fugue
68.51
20%
-76
- C6 -
-
5FYA
-
?
A:
[4-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-------
I
G
L
V
L
S
G
G
----------------
A
A
R
G
L
----
A
H
-------
I
G
V
L
K
A
L
D
E
------------------
Q
-------------
G
------------
I
--
Q
--
I
D
-
A
I
A
G
T
S
M
G
A
V
V
G
G
-
L
Y
A
--------------
S
-
G
--------------------
Y
T
P
A
E
L
E
R
--
I
A
L
E
M
--------
D
------------
W
Q
---------------------------
Q
A
L
----------------------------
P
L
---
G
V
I
Q
-----
G
Q
N
---
L
A
-
M
V
L
-
E
S
L
L
V
-------------
H
----
T
-----
S
D
N
R
-
D
--
F
D
----------
K
--
L
A
I
P
F
R
A
V
S
T
D
I
A
T
G
E
K
V
V
F
---------
R
K
G
H
L
------------------
P
Q
A
I
R
A
S
M
S
I
P
--------------------
A
V
F
A
P
--
V
E
-
I
D
-------------
G
-----------------------
R
L
L
V
D
G
G
M
V
D
-
N
I
P
V
D
V
A
R
D
-
M
-
G
V
D
V
V
I
V
V
D
I
---
G
N
P
L
R
D
RKDLST
V
L
D
V
M
N
Q
S
I
T
L
M
T
R
K
N
S
E
A
Q
L
-
A
T
L
K
P
G
D
----
V
L
--
I
Q
P
P
-----
L
S
G
Y
G
T
T
D
F
G
R
-
V
P
------------------
Q
L
I
D
---------
A
G
Y
---
R
A
-
T
T
V
L
A
A
R
-
L
A
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
68.31
21%
-22
- C6 -
-
5FYA
-
?
A:
[4-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-------
I
G
L
V
L
S
G
G
----------------
A
A
R
G
L
----
A
H
-------
I
G
V
L
K
A
L
D
E
------------------
Q
-------------
G
------------
I
--
Q
--
I
D
-
A
I
A
G
T
S
M
G
A
V
V
G
G
-
L
Y
A
--------------
S
G
Y
--------
T
P
A
E
L
----
E
R
I
A
L
E
M
D
W
Q
Q
AL--------------------------------------------------------------------------------------
P
L
---
G
V
I
Q
-----
G
Q
N
---
L
A
-
M
V
L
-
E
S
L
L
V
-------------
H
TSDN
R
-----
D
F
D
K
-----------------
L
A
I
P
F
R
A
V
S
-
T
D
I
A
T
G
E
K
V
V
F
R
K
----------
G
H
L
------------------
P
Q
A
I
R
A
S
M
S
I
P
--------------------
A
V
F
A
P
--
V
E
-
I
D
G
R
------------------------------------
L
L
V
D
G
G
M
V
D
-
N
I
P
V
D
V
A
R
D
--
M
G
V
D
V
V
I
V
V
D
I
---
G
N
P
---------
L
R
D
R
-
K
-
D
L
S
T
--------------------------
V
L
D
V
-----
M
N
-------
Q
S
-
I
T
------------------
L
M
T
R
---------
K
N
S
---
E
---
A
Q
L
A
T
L
-
K
P
G
D
-
V
L
I
Q
P
P
L
S
G
----
Y
-
G
T
T
---
D
F
------------
G
R
V
-
P
Q
L
I
D
A
G
Y
R
-
A
T
T
V
L
A
A
R
L
--
A
E
L
--------------------------------------------------------------------------------------------------
11
HHSearch
66.38
21%
-27
- C6 -
-
5FYA
-
?
B:
[3-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
K
-------
I
G
L
V
L
S
G
G
----------------
A
A
R
G
L
----
A
H
-------
I
G
V
L
K
A
L
D
E
------------------
Q
-------------
G
------------
I
--
Q
--
I
D
-
A
I
A
G
T
S
M
G
A
V
V
G
G
-
L
Y
A
--------------
S
G
Y
--------
T
P
A
E
L
----
E
R
I
A
L
E
M
D
W
Q
Q
------------------------------------------------------------DGT----------------------
L
G
-------
V
I
Q
-----
G
Q
N
---
L
A
-
M
V
L
-
E
S
L
L
V
-------------
H
TSDN
R
-----
D
F
D
K
-----------------
L
A
I
P
F
R
A
V
S
-
T
D
I
A
T
G
E
K
V
V
F
R
K
----------
G
H
L
------------------
P
Q
A
I
R
A
S
M
S
I
P
--------------------
A
V
F
A
P
--
V
E
-
I
D
G
R
------------------------------------
L
L
V
D
G
G
M
V
D
-
N
I
P
V
D
V
A
R
D
--
M
G
V
D
V
V
I
V
V
D
I
---
G
N
P
---------
L
R
D
R
-
K
-
D
L
S
T
--------------------------
V
L
D
V
-----
M
N
-------
Q
S
-
I
T
------------------
L
M
T
R
---------
K
N
S
---
E
---
A
Q
L
A
T
L
-
K
P
G
D
-
V
L
I
Q
P
P
L
S
G
----
Y
-
G
T
T
---
D
F
------------
G
R
V
-
P
Q
L
I
D
A
G
Y
R
-
A
T
T
V
L
A
A
R
L
--
A
E
L
R
-------------------------------------------------------------------------------------------------
46
Fugue
64.04
16%
12
- C5 -
-
3WMT
6
FAEB1_ASPOR
A:
[18-522]
---------------------------------------------S
F
Q
A
E
C
E
S
F
K
A
K
I
N
V
T
N
--
A
N
V
H
S
V
T
Y
V
P
A
GVNISMADNP
S
I
C
G
-------
G
-
D
P
I
T
-------------
S
T
F
A
--------
F
C
R
I
A
L
N
V
T
-------------
T
S
S
-----------------
K
S
-
Q
I
F
M
E
-
A
W
L
P
S
NYSG
R
F
L
S
T
G
N
G
G
L
----
G
G
----------
C
V
K
Y
-
D
D
M
A
Y
A
A
G
Y
G
F
A
T
V
G
T
N
N
G
H
--
F
G
----
N
N
G
V
S
F
Y
-
Q
N
T
E
-------
V
V
E
D
F
A
Y
R
-
A
L
H
T
G
V
V
V
G
----
K
E
L
T
K
---
N
F
Y
P
-----------------
Q
G
Y
N
K
S
Y
Y
L
G
C
S
T
G
G
R
-------
Q
G
W
K
S
V
Q
T
--------------------------
F
-------
P
D
D
F
D
G
V
V
A
------------------
G
-------------
A
------------
P
--
A
--
F
N
-
F
I
N
L
T
S
W
G
A
R
F
L
T
-
L
T
G
--------------
D
-
S
--------
S
A
E
-------
T
F
V
T
E
T
Q
W
----
T
A
V
H
N
--------
E
------------
I
I
---------------------------
R
Q
C
-------------------------
D
S
L
D
G
AKD
G
I
I
E
-----
D
P
D
---
L
C
-
Q
P
I
-
I
E
A
L
L
-------------
C
----
N
-----
A
T
Q
S
-
S
--
T
S
----------
G
T
C
L
T
----------
G
A
Q
V
K
T
V
N
G
V
F
S
-----
A
T
Y
----------------------
G
L
N
G
S
F
L
Y
P
--------------------
R
M
Q
P
G
S
E
L
A
-
A
Y
S
S
Y
Y
S
G
--
T
P
F
A
Y
A
-----------------------
E
D
W
Y
R
Y
V
V
F
N
-
N
T
N
W
D
-
V
A
T
-
W
T
V
Q
D
A
A
I
A
N
A
Q
---
D
P
Y
---------
Q
I
S
T
W
N
G
D
L
S
P
F
Q
K
K
----
G
G
-
K
V
L
H
Y
H
G
MEDA
I
I
--
S
S
E
S
-----
S
K
V
Y
Y
K
H
V
A
D
T
-
M
N
------------------
L
S
P
S
---------
E
L
D
S
F
Y
R
F
-
F
P
I
S
G
M
A
-
H
C
A
N
-
A
D
G
P
S
A
I
G
Q
--
G
T
G
T
F
A
G
N
N
P
Q
D
------------
N
V
L
-
L
A
M
V
Q
W
V
E
E
-
G
V
A
P
D
--
F
V
--
R
G
A
K
L
N
G
----
S
T
-
V
E
Y
R
R
K
H
C
K
Y
P
K
R
N
R
Y
V
G
P
---
G
S
Y
T
D
E
N
AWECV-----------------------------------------------------
39
Fugue
59.01
19%
-9
- C1 -
-
4UOX
9
PAT_ECOLI
A:
[7-459]
----------------------------------------------------------
S
-
A
S
--
A
L
A
C
S
A
H
A
L
N
L
----------
I
E
K
R
T------
L
-
D
H
E
E
-------------
M
K
A
L
--------
N
R
E
V
I
E
Y
F
K
-------------
E
H
V
N
P
G
---------
F
L
E
Y
R
K
S
V
T
A
G
G
D
-
Y
G
A
V
E
-----
W
Q
A
G
S
L
N
T
L
----
V
D
----------
T
Q
G
Q
--
E
F
I
D
C
L
G
G
---
F
G
I
F
N
V
G
H
RN
P
V
----
V
V
S
A
V
Q
N
-
Q
L
A
K
QPLHSQE
L
L
D
P
L
R
A
M
-
L
A
K
T
L
A
A
L
T
PGKL
K
Y
S
F
F
---
C
N
S
G
-----------------
T
E
S
V
E
A
A
L
K
L
A
K
A
Y
Q
S
-------
P
R
G
K
F
T
F
I
----------------
A
T
S
G
A
----
F
H
GKS
L
G
A
L
S
A
T
A
K
S
T
F
R
------------------
K
-------------
P
------------
F
--
M
--
P
-----------
L
L
P
G
-
F
R
H
--------------
V
-
P
FG------
N
I
E
A
M
----
R
T
A
L
N
E
C
K
K
T
G
--
D
D
V
A
A
--------
V
------------
I
L
----------------------------
E
P
-------------------------
I
Q
G
E
G
---
G
V
I
L
PPPG
Y
L
T
A
---
V
R
-
K
L
C
-
D
E
F
G
A
-------------
L
----
M
-----
I
L
D
E
-
V
--
Q
T
----------
G
M
G
R
T
G
K
M
F
A
C
E
H
E
N
V
Q
---------------
P
D
I
L
C
------------------
L
A
K
A
L
G
G
G
V
M
P
I
G
------------------
A
T
I
A
T
--
E
E
-
V
F
S
V
L
F
D
---
N
P
F
L
H
T
-----------------------
T
T
F
------
G
-
G
N
P
L
A
C
A
A
A
-
L
A
T
I
N
V
L
L
E
Q
N
L
---
P
A
Q
---------
A
E
Q
K
G
D
M
L
L
D
G
F
R
Q
L
A
R
E
Y
P
D
-
L
V
Q
E
A
R
G
----
K
G
--
M
L
M
A
-----
I
E
F
V
D
-----------------------------------------
N
E
---
I
G
-
Y
N
F
A
S
E
M
-
F
R
Q
R
-
V
L
V
-----------
A
G
T
L
N
N
A
K
-----------------------
T
I
R
-
I
E
P
P
L
T
L
T
I
--
E
Q
C
E
L
V
I
----
K
A
-
A
R
K
A
L
A
A
M
R
V
S
V
E
E
A
------------------------------------------------------------------------
38
Fugue
56.59
16%
25
* C4 *
-
4D10
-
CSN2_HUMAN
B:
[34-447]
----------------------------------------------------------------
V
D
L
E
N
Q
Y
Y
N
S
K
----------
A
----------
L
-
K
E
D
D
-------------
P
K
A
A
--------
L
S
S
F
Q
K
V
L
E
-------------
L
E
G
E
K
G
---------
E
W
G
F
K
------
A
L
-
K
Q
M
I
K
-----
I
N
F
K
L
T
N
F
P
----
E
M
----------
M
N
R
Y
-
K
Q
L
L
T
Y
I
R
S
A
V
T
R
N
Y
S
E
K
S
I
--
N
S
----
I
L
D
Y
I
S
T
S
K
Q
M
D
-------
L
L
Q
E
F
Y
E
T
-
T
L
E
A
L
------------------------------------------------
K
D
A
K
N
-------
D
R
L
W
F
K
T
N
----------------
T
K
L
G
K
----
L
Y
-------
L
E
R
E
E
Y
G
K
L
------------------
Q
-------------
K
------------
I
--
L
--
R
Q
-
L
H
Q
S
C
Q
T
Q
L
L
E
I
Y
-
A
L
E
--------------
I
-
Q
--------
M
Y
T
A
Q
----
K
N
N
K
K
L
K
A
L
Y
E
--
Q
S
L
H
I
--------
K
------------
S
----------------------------------------------------------------
A
I
P
H
------
P
L
---
I
M
-
G
V
I
-
R
E
C
G
G
-------------
K
----
M
-----
H
L
R
E
G
E
--
F
E
----------
K
A
H
T
D
F
F
E
A
F
K
N
Y
D
E
S
G
S
P
R
R
T
T
C
L
K
--------
Y
L
V
------------------
L
A
N
M
L
M
K
---
S
--------------------
G
I
N
P
F
--
D
S
-
Q
E
A
K
P
Y
K
N
D
P
E
I
-
L
A
M
-----------------------
T
N
L
V
S
A
Y
Q
N
N
-
D
-----
I
T
E
-
F
E
K
I
L
K
T
N
H
S
N
I
---
M
D
D
-----------
P
F
I
R
E
H
I
E
E
L
L
R
N
I
R
T
Q
V
L
-
I
K
L
I
K
P
Y
----
T
R
--
I
H
--------
I
P
F
I
S
K
E
L
N
I
D
V
A
------------------
D
V
E
S
---------
L
L
V
---
Q
C
-
I
L
---------
D
-
N
T
I
H
G
R
I
D
Q
--
V
N
Q
L
L
E
L
D
H
Q
K
R
-------------------------------------------
G
----
G
A
-
R
Y
T
A
L
D
K
W
T
N
Q
L
N
S
L
N
--
Q
---
A
V
V
S
K
L
A
----------------------------------------------------------
16
HHSearch
56.39
23%
22
- C6 -
-
4AKF
-
?
A:
[30-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
A
P
E
H
-------
K
G
L
V
L
S
G
G
----------------
G
A
K
G
I
----
S
Y
-------
L
G
M
I
Q
A
L
Q
E
------------------
R
-------------
G
------------
K
IK
N
--
L
T
-
H
V
S
G
A
S
A
G
A
M
T
A
S
-
I
L
A
--------------
V
G
M
--------
D
I
K
D
I
----
K
K
L
I
E
G
L
D
I
-
T
--
K
L
L
D
N
--------
S
GVGFRARG
D
R
F
R
N
I
L
D
V
I
Y
M
M
Q
M
K
K
H
L
E
S
VQQPIPPE
Q
Q
M
N
Y
G
I
L
K
Q
K
I
A
L
Y
E
D
K
L
S
R
A
GIVINN
V
D
D
I
I
N
L
T
K
---
S
V
K
D
-----
L
E
K
---
L
D
-
K
A
L
-
N
S
I
P
T
E
L
K
G
AKGEQLENP
R
----
L
-----
T
L
G
D
-
L
--
G
R
L
R
E
L
LPEENK
H
L
I
K
N
L
S
V
V
V
-
T
N
Q
T
K
H
E
L
E
R
Y
S
E
D
T
T
-----
P
Q
Q
S
I
------------------
A
Q
V
V
Q
W
S
G
A
H
P
--------------------
V
L
F
V
P
--
G
R
N
A
K
G
E
------------------------------------
Y
I
A
D
G
G
I
L
D
-
N
M
P
E
I
E
G
L
----
D
R
E
E
V
L
C
V
K
A
---
E
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
48.98
16%
36
- C4 -
-
4HNY
4
NAT1_YEAST
A:
[54-862]
V
D
S
L
A
L
K
G
L
D
L
Y
S
V
GE
K
D
D
A
A
S
Y
V
A
N
A
I
RAS
P
I
C
C
H
V
L
G
I
Y
M
R
N
T
KE
Y
K
E
S
I
K
W
F
T
A
A
L
-
N
N
GS
T
N
K
Q
I
Y
R
D
L
A
T
----------
L
Q
S
Q
I
GD
F
K
N
A
L
-
V
S
R
K
-------------
K
Y
W
E
A
F
LGY
R
A
N
W
T
S
L
A
V
A
Q
D
V
N
GE
R
Q
Q
A
I
N
T
L
S
Q
F
E
K
L
A
---------
E
G
K
I
S
D
S
-
E
K
Y
E
H
-
S
E
C
L
M
-----
Y
K
N
D
I
M
Y
K
A
A
SDN
Q
D
----------
K
L
Q
N
-
V
L
K
H
L
N
D
I
E
P
C
V
F
D
K
F
G
L
L
E
--
R
K
----
A
T
I
Y
M
K
L
-
G
Q
L
K
D
A
S
I
---
V
Y
R
T
L
I
K
R
-
N
P
D
N
F
K
Y
Y
K
----
L
L
E
V
S
L
GI
Q
G
D
N
-----------------
K
L
K
K
A
L
Y
G
K
L
E
Q
F
Y
P
R
CEPPKFI
P
L
T
F
L
Q
D
K
----------------
E
E
L
S
K
----
K
L
-------
R
E
Y
V
L
P
Q
L
E
------------------
R
GVPA
T
F
S
N
V
K
P
L
Y
Q
------------
R
--
R
--
K
S
-
K
V
S
P
L
L
E
K
I
V
L
D
Y
-
L
S
G
--------------
L
-
D
--------
P
T
Q
D
P
----
I
P
F
I
W
T
N
Y
Y
L
S
--
Q
H
F
L
F
L
KD
F
P
K
A
Q
E
------------
Y
I
---------------------------
D
A
A
-------------------------
L
D
H
T
P
---
T
L
V
E
-----
F
Y
I
---
L
K
-
A
R
I
-
L
K
H
L
G
-------------
L
----
M
D
T
A
A
G
I
L
E
E
-
G
R
Q
L
D
----------
L
Q
D
R
F
I
N
C
K
T
V
K
Y
F
L
R
A
N
N
-
I
D
K
A
V
E
V
-----
A
S
L
F
T
KNDDSVNGIKDLHLVEA
S
W
F
I
V
E
Q
A
E
A
Y
Y
--------------------
R
L
Y
L
D
--
R
K
-
K
K
L
D
D
L
A
S
Q
I
A
N
D
I
K
E
-----------------------
N
Q
W
L
V
R
K
Y
K
G
--
L
A
L
K
R
F
N
A
-
I
P
K
F
Y
K
Q
F
E
D
D
Q
---
L
D
F
---------
H
S
Y
C
M
R
K
G
T
P
R
A
Y
L
E
M
L
E
W
G
K
-
A
L
Y
T
K
P
M
----
Y
V
--
R
A
M
K
E
A
S
K
L
Y
F
Q
M
H
D
D
R
L
K
R
-
K
S
D
S
L
DENDVFG
E
K
L
I
E
TST
P
M
E
D
---------
F
A
T
---
E
F
-
Y
N
N
Y
S
M
Q
-
V
R
E
D
E
R
D
Y
I
L
D
F
E
F
--
N
Y
R
I
G
K
L
A
L
C
F
A
------------
S
L
N
-
K
F
A
K
R
F
G
T
T
S
G
L
F
G
S
M
A
I
V
--
L
L
H
A
T
R
P
----
F
D
-
P
I
L
K
K
V
V
T
K
S
L
E
K
E
Y
S
--
E
FD
W
L
N
F
Y
Q
E
K
FGKND
I
N
G
L
L
F
L
Y
R
Y
R
DDVPIG
S
S
N
L
K
E
M
I
I
S
S
L
SPLE
P
H
S
Q
N
E
I
L
Q
Y
YLYPYDVPDY
40
Fugue
48.15
16%
30
* C5 *
-
4XA2
3
MALE_ECOLI
A:
[1-490]
-------------------------------------------------------
M
K
I
E
-
E
G
------------
K
----------
L
V
I
W
-------
I
-
N
G
D
K
-------------
G
Y
N
G
--------
L
A
E
V
G
K
K
F
E
-------------
K
D
T
G
I
K
V
T
V
E
H
P
DK
L
E
E
K
F
P
Q
V
-
A
A
T
G
D
G
P
D
I
I
F
-----
W
A
H
D
R
F
G
G
Y
----
A
Q
S
GLL
A
E
I
T
P
A
A
A
F
Q
-
D
K
L
Y
P
F
T
W
D
A
V
R
Y
N
G
K
L
I
A
Y
--
P
I
----
A
V
E
A
L
S
L
-
I
Y
N
K
----------
D
L
L
P
N
-
P
P
K
T
W
E
E
I
P
----
A
L
D
K
E
---
L
K
A
K
-----------------
G
K
S
A
L
M
F
N
L
Q
E
P
Y
F
T
W
-------
P
L
I
A
A
D
G
G
----------------
Y
A
F
K
Y
----
A
A
-------
G
-------
K
------------------
Y
-------------
D
------------
I
--
K
--
D
V
-
G
V
D
N
A
G
A
K
A
G
L
T
F
-
L
V
D
--------------
L
-
I
--------
K
N
K
H
M
----
N
A
D
T
D
-
Y
S
I
A
E
--
A
A
F
N
K
--------
G
------------
E
T
---------------------------
A
M
T
-------------------------
I
N
G
P
W
---
A
W
S
N
-----
I
D
T
---
S
A
V
N
Y
G
-
V
T
V
L
-------------------
P
-----
T
F
K
G
-----
Q
----------
P
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
-----
E
N
Y
L
L
------------------
T
D
E
G
L
E
A
V
N
K
D
--------------------
K
P
L
G
A
--
V
A
-
L
K
S
Y
E
E
E
L
A
K
D
P
R
I
A
A
-----------------------
T
M
E
N
A
Q
K
G
E
I
-
M
P
N
I
P
Q
M
S
A
-
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
T
---------
V
D
A
A
L
A
A
A
Q
T
N
A
A
A
---
A
Y
Q
N
-
Y
I
A
K
S
Q
---------
V
S
T
G
-----
L
A
D
I
T
A
G
K
T
N
A
-
E
T
------------------
K
L
A
E
---------
G
L
T
---
A
A
-
L
T
D
V
E
A
L
-
G
L
Q
K
-----
S
T
N
A
C
--
S
T
I
T
T
S
I
G
T
N
G
A
------------
S
N
I
-
T
C
T
L
K
G
T
S
Q
-
I
N
S
K
K
I
E
W
I
R
D
A
D
N
A
T
N
G
----
T
T
G
A
W
R
C
K
T
D
V
---
A
E
N
L
R
--
P
---
K
S
C
G
A
S
G
S---------------------------------------------------------
43
Fugue
47.74
15%
37
- C6 -
-
1OXW
-
PAT17_SOLCD
A:
[25-384]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
M
V
T
V
L
S
I
D
G
G
G
------------------
I
R
G
I
I
P
A
-
T
I
L
E
-------
F
L
E
G
Q
L
Q
E
M
D
N
N
A
D
A
R
L
A
----
D
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
-
V
I
G
G
T
S
T
G
G
L
L
T
A
M
I
S
T
--------------
P
-
N
--------
E
N
N
R
P
----
F
A
A
----
A
K
E
I
--
V
P
F
Y
F
--------
E
------------
H
G
---------------------------
P
Q
I
-------------------------
F
N
P
S
G
---
Q
I
L
G
-----
P
K
Y
DG
K
Y
L
M
Q
V
L
-
Q
E
K
L
G
-------------
E
----
T
-----
R
V
H
Q
-
A
--
L
T
---------------
E
V
V
I
S
S
F
D
I
K
T
N
K
P
V
I
F
T
K
S
N
L
-----
A
N
S
P
E
LDAK
M
-------------
Y
D
I
S
Y
S
T
A
A
A
P
--------------------
T
Y
F
P
P
--
H
Y
-
F
V
T
N
T
S
N
G
D
----
E
Y
E
-----------------------
F
N
L
V
D
G
A
V
A
T
---------------
V
A
D
P
A
L
L
S
---
I
S
V
---------
A
T
R
L
A
Q
K
D
P
A
F
A
S
I
R
S
L
N
Y
K
K
M
L
L
L
S
L
G
T
----
G
T
--
T
S
E
F
-----
D
K
T
Y
T
A
K
E
A
A
T
-
W
T
------------------
A
V
H
W
M
--------
L
V
I
---
Q
K
M
T
D
A
A
S
S
Y
M
T
D
Y
Y
-
L
S
T
A
F
Q
A
L
D
--
S
K
N
N
Y
L
R
V
Q
E
N
A
LTGTTTEMDDAS
E
A
N
M
E
L
L
V
Q
V
G
E
N
-
L
L
K
K
P
V
S
E
D
--
N
P
E
-
T
Y
E
----
E
A
-
L
K
R
F
A
K
L
L
S
D
R
K
K
L
R
A
--
N
---
K
A
---------------------------------------------------------------
20
HHSearch
39.90
22%
-152
- C6 -
-
5IZ5
-
PA24D_HUMAN
A:
[323-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
V
-------
V
G
I
M
A
T
G
G
----------------
G
A
R
A
M
T
---
S
L
-------
Y
G
H
L
L
A
L
Q
K
------------------
L
-------------
G
------------
L
--
L
DC
V
T
-
Y
F
S
G
I
S
G
S
T
W
T
M
A
-
H
L
Y
--------------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
39.81
16%
13
- C3 -
-
4WRT
-
?
B:
[10-758]
--------------MNINPYF
L
F
I
D
V
PIQAAISTTFPYTGV
P
P
Y
S
H
G
TG
T
G
Y
T
I
D
T
V
I
R
-
T
H
--
E
Y
S
N
K
G
K
Q
Y
I
S
----------
D
V
T
G
-------
C
-
T
M
V
D
PTNGPLPEDNEPS
A
Y
A
Q
--------
L
D
C
V
L
E
A
L
D
-------------
R
M
D
E
E
H
---------
P
G
L
F
Q
A
A
-
S
Q
N
A
M
-
E
T
L
M
V
--------
T
T
V
D
K
L
----
T
Q
----------
G
R
Q
T
-
F
D
W
T
V
C
R
N
Q
P
A
A
T
A
L
N
T
T
I
T
--
S
F
R
L
N
D
L
N
G
A
D
K
G
-
G
L
I
P
-------
F
C
Q
D
I
I
D
S
-
L
D
R
P
E
M
T
F
F
----
S
V
K
N
I
---
K
K
K
L
PAKNRKG
F
L
I
K
R
I
P
M
K
V
K
D
K
I
T
K
V
E
Y
I
K
R
A
L
S
L
-------
N
T
M
T
K
D
A
E
RGKL
K
R
R
A
I
A
T
A
G
IQI
R
G
F
V
L
----
V
V
-------
E
N
L
A
K
N
I
C
E
N
LEQSGLPVGG
N
E
K
K
A
K
L
S
-------------
N
------------
A
--
V
--
A
K
-
M
L
S
N
C
P
P
G
G
I
S
M
T
-
V
T
G
D
N
T
KWNECLN
P
R
I
F
L
-
A
--------
M
T
E
R
I
T
R
DS
P
I
W
F
R
D
F
C
S
I
A
--
P
V
L
F
S
--------
N
------------
K
I
---------------------------
A
R
L
-------------------------
G
K
G
F
M
---
I
T
S
K
-----
T
K
R
---
L
K
-
A
Q
I
P
C
P
D
L
F
-------------
S
----
I
-----
P
L
E
R
-
Y
--
N
E
----------
E
T
R
A
K
L
K
K
L
K
P
F
F
N
E
E
G
T
A
S
L
S
P
G
M
M
M
-----
G
M
F
N
M
------------------
L
S
T
V
L
G
V
A
A
L
G
I
KNIGNKE
Y
L
W
D
G
L
Q
S
SD
D
F
A
L
F
V
N
--
A
K
-
D
E
E
T
C
M
E
G
I
N
D
F
Y
R
T
C
K
L
L
G
I
N
M
S
KKK
S
Y
C
N
ETG
M
F
E
F
T
S
M
F
Y
R
D
G
F
V
S
-
N
F
A
M
E
L
P
S
F
G
V
A
G
V
N
E
S
A
D
M
A
I
---
G
M
T
---------
I
I
K
N
N
M
I
N
N
G
M
G
P
A
T
A
Q
T
A
I
Q
-
L
F
I
A
D
Y
R
----
Y
T
Y
K
C
H
R
G
-----
D
S
K
V
E
G
K
R
M
K
I
-
I
K
------------------
E
L
W
E
N
TKGRDGLL
V
A
D
---
G
G
-
P
N
I
Y
N
L
R
-
N
L
H
I
-
P
E
I
V
L
K
Y
N
L
MD
P
E
Y
K
G
R
L
L
H
P
Q
N
------------
P
F
V
-
G
H
L
S
I
E
G
I
K
-
E
A
--
D
I
T
K
M
--
D
Y
D
A
V
S
G
THS
W
R
T
-
K
R
N
R
S
I
L
N
T
D
Q
R
N
M
I
L
--
E
---
E
Q
C
Y
A
K
C
C
N
L
F
E
A
C
F
NSASY
R
K
P
V
G
QHS
M
L
E
A
M
A
H
R
L
R
M
D
A
R
L
D
Y
E
S
GRMS
K
D
D
F
E
K
A
M
A
H
L
G
E
I
31
HHSearch
39.44
23%
-119
- C6 -
-
5IE7
1
?
A:
[92-122]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
------------
I
--
K
--
H
A
-
T
V
W
G
C
A
S
G
A
S
T
V
V
-
A
L
L
--------------
L
-
G
--------
Y
P
D
R
I
----
R
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
37.82
20%
-10
- C6 -
-
1OXW
-
C:
[2022-2230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Q
L
G
E
M
V
-------
T
V
L
S
I
D
G
G
----------------
G
I
R
G
I
----
I
P
-------
A
T
I
L
E
F
L
E
G
------------------
Q
-------------
L
Q
E
M
D
NNADARLA
D
--
Y
--
F
D
-
V
I
G
G
T
S
T
G
G
L
L
T
A
-
M
I
S
--------------
T
-
P
NENNRPFA
A
A
K
E
I
----
V
P
F
Y
F
E
H
G
--
P
--
Q
I
F
N
P
----------------------
S
---------------------------
G
----------------------------
Q
I
L
G
---
P
K
Y
D
-----
G
K
Y
---
L
M
-
Q
V
L
-
Q
E
K
L
G
-------------
E
----
T
-----
R
V
H
Q
-
A
----------------
L
T
E
V
V
I
S
S
-
F
D
I
K
T
N
K
P
V
I
F
T
K
S
N
L
ANSPE
L
D
A
K
M
------------------
Y
D
I
S
Y
S
T
A
A
A
P
--------------------
T
Y
F
P
P
--
H
Y
-
F
V
T
N
T
S
N
G
D
E
Y
----
E
-----------------------
F
N
L
V
D
G
A
V
A
T
V
A
D
P
A
L
L
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
34.35
26%
-108
- C6 -
-
2P62
-
?
A:
[71-157]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
P
K
-
V
L
K
-
S
V
L
D
S
V
K
L
G
-
L
L
N
--------------
V
-
E
--------
E
V
Y
V
V
----
R
D
V
D
E
G
N
D
V
F
E
--
W
V
L
S
F
--------
L
------------
R
E
---------------------------
R
E
V
-------------------------
R
V
D
N
G
---
A
I
-------
V
T
E
---
G
V
-
K
I
Y
-
P
Y
G
M
G
-------------
N
----
L
-----
T
L
N
E
-
P
--
F
V
----------
K
E
K
K
E
L
E
L
S
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
34.02
26%
-84
- C6 -
-
3EN0
-
CPHB_SYNY3
A:
[111-161]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
-------
T
G
I
F
M
T
G
G
----------------
D
Q
L
R
L
C
G
L
L
A
D
-------
T
P
L
M
D
R
I
R
Q
------------------
R
-------------
V
------------
H
--
N
--
G
E
I
S
L
A
G
T
S
A
G
A
A
V
M
G
-
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
30.68
21%
-132
- C6 -
-
2OCG
1
BPHL_HUMAN
A:
[92-115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------------
F
--
K
--
K
V
-
S
L
L
G
W
S
D
G
G
I
T
A
L
-
I
A
A
--------------
A
-
K
--------
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
30.63
21%
-129
- C6 -
-
2OCI
1
BPHL_HUMAN
A:
[92-115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------------
F
--
K
--
K
V
-
S
L
L
G
W
S
D
G
G
I
T
A
L
-
I
A
A
--------------
A
-
K
--------
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
29.43
20%
-
- C- -
-
4PK9
-
PAT17_SOLCD
A:
[24-230]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
G
E
M
V
-------
T
V
L
S
I
D
G
G
----------------
G
I
R
G
I
----
I
P
-------
A
T
I
L
E
F
L
E
G
------------------
Q
-------------
L
Q
E
M
D
NNADARLA
D
--
Y
--
F
D
-
V
I
G
G
T
S
T
G
G
L
L
T
A
-
M
I
S
--------------
T
-
P
NENNRPFA
A
A
K
E
I
----
V
P
F
Y
F
E
H
G
--
P
--
Q
I
F
N
P
----------------------
S
---------------------------
G
----------------------------
Q
I
L
G
---
P
K
Y
D
-----
G
K
Y
---
L
M
-
Q
V
L
-
Q
E
K
L
G
-------------
E
----
T
-----
R
V
H
Q
-
A
----------------
L
T
E
V
V
I
S
S
-
F
D
I
K
T
N
K
P
V
I
F
T
K
S
N
L
ANSPE
L
D
A
K
M
------------------
Y
D
I
S
Y
S
T
A
A
A
P
--------------------
T
Y
F
P
P
--
H
Y
-
F
V
T
N
T
S
N
G
D
E
Y
----
E
-----------------------
F
N
L
V
D
G
A
V
A
T
V
A
D
P
A
L
L
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
26.13
25%
28
- C6 -
-
5B64
-
?
B:
[68-122]
--------------------------------------------------------
Q
V
R
-
R
K
--
G
K
G
K
Q
I
W
S
L
E
K
----------
L
E
N
R
-------
L
L
D
M
R
D
-------------
L
Y
Q
E
--------
W
K
----
E
C
E
-------------
E
D
S
P
V
S
---------
R
S
Y
F
K
R
A
-
D
P
F
Y
D
-
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------