@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKD1: (2017-10-26 )
MKKRNNSQNLIMLKHDFASHIEDLKCATKPRSEALGRHLWTCTIDADFYWLKFHLPNVHAQSEQDFLHELQFYEDITYKKANWLLPFKIIEGRTISQQTQFQGKVLVLPDTECWFDDLDQKQNLKNINEKIYLALVKLAELHELGWIHGDIKKEHFRKFKQELYLIDFEKTRLISSPDPITDATPRYMAPELFHGANKTVQSDLYALGIVLYEWLTQTRLQANSYHEWAVLHCQKLNVELPSSFQIFLPLLSGLLQKQQQNRFSNVHEAINCLKALST
Atome Classification :
(20 SA)
-------.........10........20........30........40..-------.---------.-....50........60........70.....-.-..80........90........100.....--..110.--.....---.120----------------.........130.....-----..140...--....150.....---..---160-.-----.......170.....-----.-----------.180--.......190..---..------.-..200.......210....-----------------...220.....-.-.230--.-...---.----..240.-.-----..-------------...250.......260--.......270-.......---------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------MKKRNNSQ
N
L
I
M
L
K
H
D
F
A
S
H
I
E
D
L
KCATK
P
R
S
E
A
LGR
H
L
W
T
C
T
-------I---------D-A
D
F
Y
W
L
K
F
HLPNVHAQ
S
E
Q
D
F
L
H
E
L
Q
F
Y
E
DI-T-YKKA
N
W
L
L
P
F
K
I
IEGRTISQQTQFQ
G
K
V
L
V
--
L
PDT
E
C
--
W
F
D
D
L
---
D
Q
------------------
K
Q
N
L
K
N
I
N
E
K
I
Y
L
A
L
V
K
-----
L
A
E
L
H
E
L
G
--
W
IH
G
D
I
K
K
E
H
F
R
---
K
F
---
K
-Q-E-----
L
Y
L
I
DF
E
K
TRLISSP-----D-----------PITD--ATPRYM
A
P
E
L
FH---GA------N-
K
T
V
Q
S
D
L
Y
A
L
G
I
V
L
Y
E
W
L
T
-----------------
Q
TRLQANSYH
E
-
W
-
A
V
L
H
--
C
-
Q
K
L---N----VELPS
S
-
F
-----
Q
I
-------------
F
L
P
L
L
S
G
L
L
Q
K
Q
Q
Q
N
R
--
F
S
N
V
H
E
A
I
N
--
C
L
K
A
LST---------------------------------------------------------------------------
58
HHSearch
70.61
18%
-36
- C1 -
-
1TKI
-
B:
[21-274]
---------------------------
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
-
V
H
R
C
V
-------
E
TS-------
S
-
K
K
T
Y
M
A
K
F
V
K
V
K
G
--
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
-
H
--
R
N
I
L
H
L
H
E
S
F
E
S
--------
M
E
E
L
V
M
I
FE
F
I
S
G
L
D
--
I
F
E
R
I
---
N
T
SAF---------------
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
-----
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
---
Y
Q
TRR
S
-
S
-
T
-----
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
DN---
F
-----------
R
L
L
F
--
T
A
P
E
Y
Y
A
P
E
V
H
Q
---
H
D
------
V
-
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-----------------
G
I
N
P
F
L
A
E
T
N
Q
-
Q
-
I
I
E
N
--
I
-
M
N
A
---
E
YTFD
E
E
A
F
K
E
I
S
-----
I
E
-------------
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
--
M
T
-
A
S
E
A
L
Q
------------------------------------------------------------------------------------
35
Fugue
69.09
17%
13
- C1 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
---------
G
S
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
---------------------------
T
-
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
R
P
V
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
-
H
K
N
--------
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
--
M
E
F
C
P
C
GS
L
Y
T
V
L
---
E
E
------------------
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
--
I
V
H
R
N
I
K
P
G
N
I
M
---
R
V
---
I
-
G
-
E
DG
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
-----
E
-----------
Q
F
V
S
LY
G
T
E
E
Y
L
H
P
D
M
Y
E
---
R
A
VLD
H
Q
K
K
-
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
GSLPFRPFEGPRRN
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
-
A
-
I
S
G
V
--
Q
-
K
A
E
---
N
----
G
P
I
D
W
S
-
G
-----
D
M
PVSCSLS
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
WG
F
D
Q
F
F
A
E
T
S
--
D
I
L
H
R
M
V
I
H
V
F
S
LQQM
T
A
H
K
I
Y
I
H
SYNT
A
T
I
F
H
E
L
V
Y
K
Q
T
KIISSN
Q
E
L
I
Y
EG
R
R
L
V
L
E
PGRLAQHFPKTTEE
N
P
I
F
V
V
S
RE
47
HHSearch
67.11
19%
9
- C1 -
-
4Y0X
1
PKNG_MYCTU
A:
[115-364]
------------------------
D
I
V
A
G
Q
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
-
I
Y
L
A
L
-------
D
RNV------
N
-
G
R
P
V
V
L
K
G
L
V
H
S
G
D
A
E
A
Q
A
M
A
M
A
E
R
Q
F
L
A
E
V
-
V
-
H
--
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
R
---
H
G
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
--
L
K
R
S
K
---
G
Q
------------------
K
L
P
V
A
E
A
I
A
Y
L
L
E
I
L
P
A
-----
L
S
Y
L
H
S
I
G
--
L
V
Y
N
D
L
K
P
E
N
I
M
---
L
T
---
E
-
E
-
Q
-----
L
K
L
I
D
L
G
A
V
S
R
I
N
S
------
F
-----------
G
Y
L
Y
--
G
T
P
G
F
Q
A
P
E
I
V
R
---
T
G
------
P
--
T
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
-----------------
D
L
P
T
R
N
G
R
Y
V
D
-
G
---
L
P
--
E
-
D
D
P
---
V
----
L
---
K
T
-
Y
-----
D
S
-------------
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
--
F
T
T
A
E
E
M
S
A
--
Q
L
T
G
------------------------------------------------------------------------------
41
HHSearch
66.64
16%
-5
* C1 *
-
3BKB
7
A:
[106-372]
--------------------
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
-
V
F
S
G
R
-------
L
RA-------
D
-
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
--
P
N
I
V
R
L
I
G
V
C
T
Q
------
K
Q
P
I
Y
I
V
M
E
--
L
V
Q
G
G
D
--
F
L
T
F
L
---
R
T
EGA---------------
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
-----
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
---
V
T
---
E
K
N
-
V
-----
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
-----------
G
L
R
Q
--
V
P
V
K
W
T
A
P
E
A
L
N
---
Y
G
------
R
-
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
----------------
G
A
S
P
Y
P
N
L
S
N
Q
-
Q
-
T
R
E
F
--
V
E
K
G
G
---
R
----
L
P
C
P
E
L
C
P
-----
D
A
-------------
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
--
P
S
-
F
S
T
I
Y
Q
--
E
L
Q
S
I
-----------------------------------------------------------------------------
49
HHSearch
66.34
16%
-56
- C1 -
-
5TE0
10
AAK1_HUMAN
A:
[13-286]
----------------------
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
-
V
F
L
V
R
-------
T
S--------
N
-
G
M
K
C
A
L
K
R
M
F
V
N
N
-
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
-
S
G
H
--
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
------
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
--
V
V
N
L
M
---
N
Q
R
L
QT--------------
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
-----
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
---
L
H
---
D
R
G
-
H
-----
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
-----
P
QTEG
V
N
A
V
E
D
E
I
K
K
Y
--
T
T
L
S
Y
R
A
P
E
M
V
N
LYS
G
K
------
I
-
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
-----------------
F
T
L
P
F
G
E
S
Q
V
A
-
I
---
C
D
--
G
-
N
F
T
---
I
----
P
D
N
S
R
Y
-
S
-----
Q
D
-------------
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
--
P
D
-
I
Y
Q
V
S
Y
--
F
S
--------------------------------------------------------------------------------
50
HHSearch
65.72
19%
9
- C1 -
-
4Y12
1
PKNG_MYCTU
A:
[115-364]
------------------------
D
I
V
A
G
Q
Y
E
V
K
G
C
I
A
H
G
G
L
G
W
-
I
Y
L
A
L
-------
D
RNV------
N
-
G
R
P
V
V
L
K
G
L
V
H
S
G
D
A
E
A
Q
A
M
A
M
A
E
R
Q
F
L
A
E
V
-
V
-
H
--
P
S
I
V
Q
I
F
N
F
V
E
H
T
D
R
H
---
G
D
P
V
G
Y
I
V
M
E
Y
V
G
G
Q
S
--
L
K
R
S
K
---
G
Q
------------------
K
L
P
V
A
E
A
I
A
Y
L
L
E
I
L
P
A
-----
L
S
Y
L
H
S
I
G
--
L
V
Y
N
D
L
K
P
E
N
I
M
---
L
T
---
E
-
E
-
Q
-----
L
K
L
I
D
L
G
A
V
S
R
I
N
S
------
F
-----------
G
Y
L
Y
--
G
T
P
G
F
Q
A
P
E
I
V
R
---
T
G
------
P
--
T
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
-----------------
D
L
P
T
R
N
G
R
Y
V
D
-
G
---
L
P
--
E
-
D
D
P
---
V
----
L
K
T
----
Y
-----
D
S
-------------
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
--
F
T
T
A
E
E
M
S
A
--
Q
L
T
G
------------------------------------------------------------------------------
57
HHSearch
60.59
16%
-19
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-258]
--------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
-
V
K
L
A
C
-------
H
IL-------
T
-
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
--
Q
H
I
C
Q
L
Y
H
V
L
E
T
--------
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
--
L
F
D
Y
I
---
I
S
Q
D----------------
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
-----
V
A
Y
V
H
S
Q
G
--
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
D
---
E
Y
H
-
K
-----
L
K
L
I
D
F
G
L
C
A
K
P
---------------------------
S
L
A
Y
A
A
P
E
L
I
Q
---
G
K
------
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-----------------
G
F
L
P
F
D
D
D
N
V
M
-
A
-
L
Y
K
K
--
I
-
M
R
G
---
K
----
Y
D
V
P
K
W
L
S
-----
P
S
-------------
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
--
I
S
-
M
K
N
L
L
N
------------------------------------------------------------------------------------
43
HHSearch
60.46
15%
-6
- C1 -
-
3CBL
3
A:
[107-372]
---------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
-
V
F
S
G
R
-------
L
RA-------
D
-
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
--
P
N
I
V
R
L
I
G
V
C
T
Q
------
K
Q
P
I
Y
I
V
M
E
--
L
V
Q
G
G
D
--
F
L
T
F
L
---
R
T
EGA---------------
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
-----
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
---
V
T
---
E
K
N
-
V
-----
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
VYAAS
G
-----------
G
L
R
Q
--
V
P
V
K
W
T
A
P
E
A
L
N
---
Y
G
------
R
-
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L----------------
G
A
S
P
Y
P
N
L
S
N
Q
-
Q
T
R
E
F
V
--
E
-
K
G
G
---
R
----
L
P
C
P
E
L
C
P
-----
D
A
-------------
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
--
P
S
-
F
S
T
I
Y
Q
--
E
L
Q
S
I
-----------------------------------------------------------------------------
34
Fugue
59.28
17%
29
- C1 -
-
1KOB
1
?
A:
[23-374]
INDYDKF
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
-------
K
---------
A
-
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
-
H
P
K
--------
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
--
F
L
S
G
G
E
--
L
F
D
R
I
A
AE
D
Y
------------------
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
-----
L
K
H
M
H
E
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
CET
K
K
---
A
-
S
-
S
-----
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
-----
E
-----------
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
---
R
E
------
P
-
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-----------------
G
L
S
P
F
A
G
E
D
D
L
-
E
-
T
L
Q
N
--
V
-
K
R
C
---
D
----
W
E
F
D
E
D
-
A
FSSVS
P
E
-------------
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
--
L
T
-
V
H
D
A
L
E
HP
W
L
K
G
D
H
S
NLTSRIPSSRY
N
K
I
R
Q
K
I
K
E
K
Y
ADWPAPQPAIGRIANFSSLRKHRPQEYQ
I
Y
D
S
Y
F
DRKEA--------------
40
HHSearch
58.78
13%
-7
- C1 -
-
2PSQ
-
FGFR2_HUMAN
A:
[72-362]
-------------------
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
-
V
V
M
A
E
-------
A
V
GIDKDKPK
E
-
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
--
K
N
I
I
N
L
L
G
A
C
T
Q
--------
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
--
L
R
E
Y
L
---
R
A
R
RPPPEE-----------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
-----
M
E
Y
L
A
S
Q
K
--
C
I
H
R
D
L
A
A
R
N
V
L
---
V
T
---
E
N
N
-
V
-----
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
DYYKK
T
-----------
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
---
D
R
------
V
-
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
----------------
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
K
L
--
L
K
E
G
H
---
R
----
M
D
K
P
A
N
-
C
T----
N
E
-------------
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
--
P
T
-
F
K
Q
L
V
E
--
D
L
D
R
I
-----------------------------------------------------------------------------
52
HHSearch
56.30
14%
26
- C1 -
-
4CKJ
16
A:
[16-309]
---------------------
P
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
-
V
V
K
A
T
-------
A
F
HLKGRA--
G
-
Y
T
T
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
--
P
H
V
I
K
L
Y
G
A
C
S
Q
--------
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
--
L
R
G
F
L
---
R
E
SRKVR-------------
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
-----
M
Q
Y
L
A
E
M
K
--
L
V
H
R
D
L
A
A
R
N
I
L
---
V
A
---
E
G
R
-
K
-----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
DSYVK
R
-----------
S
Q
G
R
--
I
P
V
K
W
M
A
I
E
S
L
F
---
D
H
------
I
-
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L----------------
G
G
N
P
Y
P
G
I
P
P
E
R
L
-
F
N
L
L
--
K
-
T
G
H
---
R
----
M
E
R
P
D
N
C
S
-----
E
E
-------------
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
--
P
V
-
F
A
D
I
S
K
--
D
L
E
K
M
-----------------------------------------------------------------------------
60
HHSearch
56.19
14%
10
- C1 -
-
5AMN
7
A:
[16-295]
---------------------
P
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
-
V
V
K
A
T
-------
A
F
HLKGRA--
G
-
Y
T
T
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
--
P
H
V
I
K
L
Y
G
A
C
S
Q
--------
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
--
L
R
G
F
L
---
R
E
S
R
KVER------------
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
-----
M
Q
Y
L
A
E
M
K
--
L
V
H
R
D
L
A
A
R
N
I
L
---
V
A
---
E
G
R
-
K
-----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
DSYVK
R
-----------
S
Q
G
R
--
I
P
V
K
W
M
A
I
E
S
L
F
---
D
H
------
I
-
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L----------------
G
G
N
P
Y
P
G
I
P
P
E
-
R
L
F
N
L
L
--
K
-
T
G
H
---
R
----
M
E
R
P
D
N
C
S
-----
E
E
-------------
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
--
P
V
-
F
A
D
I
S
K
--
D
L
E
K
M
-----------------------------------------------------------------------------
48
HHSearch
54.74
14%
-1
- C1 -
-
3TT0
1
FGFR1_HUMAN
A:
[61-350]
--------------------
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
-
V
V
L
A
E
-------
A
I
GLDKDKPN
R
-
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
--
K
N
I
I
N
L
L
G
A
C
T
Q
------
D
G
P
L
Y
V
I
V
E
--
Y
A
S
K
G
N
--
L
R
E
Y
L
---
Q
A
R
RPPGLEYSYNPSHNP
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
-----
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
---
V
T
---
E
D
N
-
V
-----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
YYKK
T
-----------
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
---
D
R
------
I
-
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
----------------
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
K
L
--
L
K
E
G
H
---
R
----
M
D
K
P
S
N
C
T
-----
N
E
-------------
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
--
P
T
-
F
K
Q
L
V
E
--
D
L
D
R
I
-----------------------------------------------------------------------------
56
HHSearch
54.37
14%
6
- C1 -
-
5A46
4
FGFR1_HUMAN
A:
[32-321]
--------------------
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
-
V
V
L
A
E
-------
A
I
GLDKDKPN
R
-
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
--
K
N
I
I
N
L
L
G
A
C
T
Q
------
D
G
P
L
Y
V
I
V
E
--
Y
A
S
K
G
N
--
L
R
E
Y
L
---
Q
A
R
RPPGLE
E
----------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
-----
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
---
V
T
---
E
D
N
-
V
-----
M
K
I
A
D
F
G
L
A
R
D
---
I
DYYKK
T
-----------
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
---
D
R
------
I
-
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
----------------
G
G
S
P
Y
P
G
V
P
V
E
E
L
-
F
K
L
L
--
K
-
E
G
H
---
R
----
M
D
K
P
S
N
C
T
-----
N
E
-------------
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
--
P
T
-
F
K
Q
L
V
E
--
D
L
D
R
I
-----------------------------------------------------------------------------
46
HHSearch
52.83
14%
-7
- C1 -
-
4ASE
1
A:
[57-345]
---------------------
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
-
V
I
E
A
D
-------
A
F
GIDKTA--
T
-
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
-
G
-
H
-
H
L
N
V
V
N
L
L
G
A
C
T
K
-------
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
--
L
S
T
Y
L
---
R
S
K
R
NEFVPYYKD-------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
-----
M
E
F
L
A
S
R
K
--
C
I
H
R
D
L
A
A
R
N
I
L
---
L
S
---
E
K
N
-
V
-----
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
PD
Y
V
R
K
-----------
G
D
A
R
--
L
P
L
K
W
M
A
P
E
T
I
F
---
D
R
------
V
-
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
----------------
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
-
E
G
T
---
R
----
M
R
A
P
D
Y
T
T
-----
P
E
-------------
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
--
P
T
-
F
S
E
L
V
E
--
H
L
G
N
L
-----------------------------------------------------------------------------
54
HHSearch
52.58
13%
-14
- C1 -
-
4Y95
4
?
C:
[2-261]
-----------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
-
V
K
Y
G
K
-------
W
---------
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
--
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
--
E
K
L
V
Q
L
Y
G
V
C
T
--------
K
Q
R
P
I
F
I
I
TE
Y
M
A
N
G
C
--
L
L
N
Y
L
---
R
E
MRH---------------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
-----
M
E
Y
L
E
S
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
---
V
N
---
D
Q
G
-
V
-----
V
K
V
S
D
F
G
M
T
R
F
V
L
D
D
EYTS-
S
-----------
T
G
T
K
--
F
P
V
K
W
A
S
P
E
V
L
M
---
Y
S
------
K
-
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L----------------
G
K
M
P
Y
E
R
F
T
N
S
-
E
-
T
A
E
H
I-
A
-
Q
G
L
---
R
----
L
P
R
P
H
L
A
S
-----
E
R
-------------
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
--
P
T
-
F
K
I
L
L
S
--
N
I
L
D
V
-----------------------------------------------------------------------------
53
HHSearch
51.93
12%
-9
- C1 -
-
5J87
1
BTK_HUMAN
B:
[8-270]
--------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
-
V
K
Y
G
K
-------
W
---------
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
--
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
--
E
K
L
V
Q
L
Y
G
V
C
T
--------
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
--
L
L
N
Y
L
---
R
E
MRH---------------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
-----
M
E
Y
L
E
S
K
Q
--
F
L
H
R
D
L
A
A
R
N
C
L
---
V
N
---
D
Q
G
-
V
-----
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
EYTS-
S
-----------
V
G
S
K
--
F
P
V
R
W
S
P
P
E
V
L
M
---
Y
S
------
K
-
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L----------------
G
K
M
P
Y
E
R
F
T
N
S
-
E
-
T
A
E
H
--
I
A
Q
G
L
---
R
----
L
Y
R
P
H
L
A
S
-----
E
K
-------------
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
--
P
T
-
F
K
I
L
L
S
--
N
I
L
D
V
-----------------------------------------------------------------------------
51
HHSearch
51.83
15%
-11
- C1 -
-
4G3F
1
A:
[54-314]
------------------------
R
E
E
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
-
V
H
R
M
K
-------
D
KQ-------
T
-
G
F
Q
C
A
V
K
K
V
R
L
E
------
V
F
R
V
E
E
L
V
A
C
A
G
L
-
S
-
S
--
P
R
I
V
P
L
Y
G
A
V
R
E
--------
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
--
L
G
Q
L
I
---
K
Q
M
G----------------
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
-----
L
E
Y
L
H
T
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
---
L
S
---
S
D
G
S
R
-----
A
A
L
C
D
F
G
H
A
L
C
L
--------------------
D
Y
I
P
--
G
T
E
T
H
M
A
P
E
V
V
M
---
G
K
------
P
-
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-----------------
G
C
H
P
W
T
Q
Y
F
R
G
-
P
-
L
C
L
K
--
I
-
A
S
E
PPP
I
----
R
E
I
P
P
S
-
C
A----
P
L
-------------
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
--
A
S
-
A
M
E
L
R
R
--
K
V
G
K
A
-----------------------------------------------------------------------------
55
HHSearch
50.88
14%
17
- C1 -
-
5A46
2
B:
[32-321]
--------------------
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
-
V
V
L
A
E
-------
A
I
GLDKPN--
R
-
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
--
K
N
I
I
N
L
L
G
A
C
T
Q
------
D
G
P
L
Y
V
I
V
E
--
Y
A
S
K
G
N
--
L
R
E
Y
L
---
Q
A
R
RPPHNPE
E
---------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
-----
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
---
V
T
---
E
D
N
-
V
-----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
DYYKK
T
-----------
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
---
D
R
------
I
-
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
----------------
G
G
S
P
Y
P
G
V
P
V
E
E
L
-
F
K
L
L
--
K
-
E
G
H
---
R
----
M
D
K
P
S
N
C
T
-----
N
E
-------------
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
--
P
T
-
F
K
Q
L
V
E
--
D
L
D
R
I
-----------------------------------------------------------------------------
42
HHSearch
49.82
12%
-6
- C1 -
-
3ZZW
-
ROR2_HUMAN
A:
[4-288]
-----------------------
K
E
I
S
L
S
A
V
R
F
M
E
E
L
G
E
D
R
F
G
K
-
V
Y
K
G
H
L
F
G
PAPG
E
---------
Q
-
T
Q
A
V
A
I
K
T
L
K
D
K
A
E
G
P
L
R
E
E
F
R
H
E
A
M
L
R
A
R
L
-
Q
-
H
--
P
N
V
V
C
L
L
G
V
V
T
K
--------
D
Q
P
L
S
M
I
F
S
Y
C
S
H
G
D
--
L
H
E
F
L
V
M
R
-
S
------------------
A
L
E
P
P
D
F
V
H
L
V
A
Q
I
A
A
G
-----
M
E
Y
L
S
S
H
H
--
V
V
H
K
D
L
A
T
R
N
V
L
---
V
Y
---
D
K
L
-
N
-----
V
K
I
S
D
L
G
L
F
R
E
V
Y
A
A
D
Y
Y
K
L
L
-----------
G
N
S
L
--
L
P
I
R
W
M
A
P
E
A
I
M
---
Y
G
------
K
-
F
S
I
D
S
D
I
W
S
Y
G
V
V
L
W
E
V
F
S
Y
----------------
G
L
Q
P
Y
C
G
Y
S
N
Q
-
D
-
V
V
E
M
I
-
R
-
N
R
Q
---
V
----
L
P
C
P
D
D
C
P
-----
A
W
-------------
V
Y
A
L
M
I
E
C
W
N
E
F
P
S
R
R
--
P
R
-
F
K
D
I
H
S
--
R
L
R
A
W
G
----------------------------------------------------------------------------