@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKE6: (2017-10-26 )
MSLLLKVRQNVPQVQSIKTSLKKRAGQKIPHMLSNASDLFFRGSEIALSGKTPFDVIYKHEIISLRHYRIETEASAHKHRVPLVIVPPLAVNMLIYDLFPTRSLIRYFLDQGFEVYLIDWGVPTRNQAKYNFGTYVKVFMPEMLKQVRIHSGQQQLSLHGWSLGGALSLCYTALFKDKDIKNLMILASPIDTHKAGYMGKLYGSLTKPAQWVRKHTPFRIRQHVPSEVFHIHGWQNTLGFKLTAPIGNLKTYWQLLKNLDNREFIVDHATSSSFIDNMLAYPGGVMRDIILRFWIDNELSTGVIKFGELTAYLKDIDCSVLAVGGDTDIIVTADAVKPLMDLISSQDKTFKTVPSGHMGVVSGSQAPTSVWPEMSNWLAMRSD
Atome Classification :
(20 SA)
-.........10.---.......20.-.......30........40........50........60........70........80........90........-100.......110.......------------120-.---...-------.....-----130---...------......140.......150-........160.....---..170----....---..-.--180...--....190....-...200..---...-..210....-------...220..-...-..230.......240........250....-...260-..--...----....270...--....280.-----..---....290.-......300.......310-....--...320.......330.......340.......350...-....360--.......370.......380.-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-M
S
L
L
L
K
V
R
QNVP---
Q
V
Q
S
I
K
T
S
L
K
-
K
RAGQKI
P
H
M
LSNAS
D
L
F
F
RG
S
E
I
A
LSGKT
P
F
D
V
I
Y
K
H
E
I
I
S
L
R
H
Y
R
I
ETEASAHKHRV
P
L
V
I
VP
P
L
A
V
N
M
L
I
Y
DLF-P
T
R
S
L
I
R
Y
F
L
DQG
F
E
V
Y
L
I
D------------W---G---VPT-------RNQAK-----Y-----NF
G
------
T
Y
V
K
V
F
M
P
E
M
L
K
Q
V
R
IHS--GQ
Q
Q
L
S
LHGWSL
G
G
A
L
---
S
L
C
Y
T
----
A
L
FK---DK-D--IK
N
L
M
I
--
L
ASPIDTHKAG-
Y
M
G
K
L
Y
GS---LT
K
-
P
A
Q
W
V
R
KHT-------P
F
R
I
R
QHV-PSE-
V
F
H
I
HGWQNTL
G
F
K
-
L
TAPIG
N
L
K
T
Y
W
Q
L
L
-
K
NLD---N
R
--
E
F
I
----
V
DHAT
S
S
S
F
I
--
D
N
M
LAYP
G
-----
G
V
---
M
R
D
I
I
L
R
F
-WIDNELST
G
V
I
K
F
G
E
L
T
A
Y
-
L
K
DI--
D
C
S
V
L
A
VGGDT
D
I
I
V
T
A
D
A
V
K
P
L
M
D
L
I
SSQDK
T
F
K
TVPS-GH
M
G
V
VS--GSQAPTSV
W
P
E
M
S
N
W
L
AMRSD-----------------------------
21
Fugue
82.54
21%
-83
- C2 -
-
5T6O
-
PHAC_CUPNH
A:
[1-389]
------------------------------------------
S
A
F
E
V
G
R
N
V
A
V
---
T
E
G
A
V
V
F
E
N
E
Y
F
Q
L
L
Q
Y
K
P
L
T
D
---
K
V
H
A
R
P
L
L
M
V
P
P
C
I
N
K
Y
Y
I
L
D
L
Q
-
P
E
S
S
L
V
R
H
V
V
E
Q
G
H
T
V
F
L
V
S
------------
W
---
R
---
N
P
D
-------
A
S
M
A
G
-----
S
-----
T
W
D
------
D
Y
I
E
H
A
A
I
R
A
I
E
V
A
R
D
I
S
--
G
Q
D
K
I
N
V
L
G
F
A
V
G
G
T
I
---
V
S
T
A
L
----
A
V
L
A
A
R
G
E
H
-
P
--
A
A
S
V
T
L
--
L
T
T
L
L
D
F
A
D
T
G
-
I
L
D
V
F
V
D
E
GHV
Q
G
A
-
P
C
A
L
L
R
G
L
E
-------
L
A
N
T
F
S
F
L
R
P
N
D
-
L
V
W
N
Y
V
V
D
N
Y
L
K
G
N
-
T
P
V
P
-------
F
D
L
L
-
F
W
N
G
---
D
A
--
T
N
L
P
G
P
W
Y
C
W
Y
L
R
H
T
Y
L
--
Q
N
E
L
K
V
P
G
KLTVC
G
V
P
V
D
L
A
S
I
D
V
P
T
-
Y
I
Y
G
S
R
E
D
H
I
V
P
W
T
A
A
Y
A
S
-
T
A
L
L
--
A
N
K
L
R
F
V
L
G
A
S
G
H
I
A
G
V
--
I
N
P
P
A
K
N
K
R
S
H
W
T
N
D
A
L
P
E
S
-
P
Q
Q
W
L
A
G
--
A
I
E
H
H
G
S
W
W
P
D
W
T
A
W
L
A
G
Q
A
G
AKRAAPANYGNARYRAIEPAPGRYVKAKA
29
Fugue
68.90
21%
6
- C2 -
-
4ZWN
-
MGLL_YEAST
A:
[22-331]
S
A
P
Y
P
Y
K
V
Q
T
T
V
P
---
E
L
Q
Y
E
N
F
D
G
A
-
K
F
G
Y
M
F
W
P
--
V
Q
N
G
T
N
-
E
V
R
G
R
V
L
L
I
H
G
F
G
E
Y
------------------------
T
K
I
Q
F
R
L
M
D
H
L
S
L
N
--------------------
G
Y
E
S
F
T
F
D
------------
Q
RGA
G
---
V
T
S
-------
P
G
R
S
K
GVTD
E
Y
-----
H
V
F
------
N
D
L
E
H
F
V
E
K
N
L
S
E
C
K
A
K
G
----
I
P
L
F
M
W
G
H
S
M
G
G
G
I
---
C
L
N
Y
A
----
C
Q
G
K
---
H
K
-
N
--
E
I
S
G
Y
I
--
G
S
G
P
L
I
--------------------------------------------------
I
L
H
P
H
T
M
Y
N
----
K
-
P
T
Q
I
I
A
P
L
L
A
K
F
S
P
R
-
V
R
I
D
---
T
G
--
L
D
L
----
K
G
I
T
S
D
K
A
Y
R
--
A
F
L
G
S
D
P
M
-----
S
V
---
P
L
Y
G
S
F
R
Q
-
I
H
D
F
M
Q
R
G
A
K
L
Y
K
N
E
N
N
Y
I
-
Q
K
N
F
AK
D
K
P
V
I
I
M
H
G
Q
D
D
T
I
N
D
P
K
G
S
E
K
F
I
R
D
C
P
S
A
D
K
E
L
K
L
Y
P
G
-
A
R
H
S
I
F
S
LE
T
D
K
V
F
N
T
V
F
N
D
M
K
Q
W
L
D
K
H
T
T
TE---------------------------
22
Fugue
68.38
13%
-29
- C2 -
-
1HLG
4
LIPG_HUMAN
A:
[1-371]
----------
S
P
E
---
V
T
M
N
I
S
Q
M
I
T
-
Y
W
G
Y
P
N
E
E
Y
E
V
V
T
E
D
G
------------------------
Y
I
L
E
V
N
R
I
P
Y
G
K
K
N
S
G
Q
R
P
V
V
F
L
Q
H
G
L
L
A
S
A
T
N
W
I
S
N
L
P
N
N
S
L
A
F
I
L
A
D
A
G
Y
D
V
W
L
G
N
S
RGNTWARRNLY
Y
---
S
---
P
D
S
-------
V
E
F
W
A
-----
F
-----
S
F
D
------
E
M
A
K
Y
D
L
P
A
T
I
D
F
I
V
K
K
T
--
G
Q
K
Q
L
H
Y
V
G
H
S
Q
G
T
T
I
---
G
F
I
A
F
----
S
T
N
P
---
S
L
-
A
K
R
I
K
T
F
Y
A
--
L
A
P
V
A
T
V
K
Y
T
K
S
L
I
N
K
L
R
F
V
---
P
Q
S
-
L
F
K
F
I
F
G
D
K
-------
I
F
Y
P
H
N
F
F
-
D
Q
F
-
L
A
T
E
V
C
S
R
E
M
L
N
L
L
-
C
S
N
A
L
F
I
I
C
G
F
D
S
K
N
-
F
N
T
S
---
R
L
--
D
V
Y
----
L
S
H
N
P
A
G
T
S
V
--
Q
N
M
F
H
W
T
Q
-----
A
V
---
K
S
G
K
F
Q
A
Y
D
W
G
S
P
V
Q
N
R
M
H
Y
D
Q
S
Q
P
P
Y
Y
N
V
T
A
M
--
N
V
P
I
A
V
W
N
G
G
K
D
L
L
A
D
P
Q
D
V
G
L
L
L
P
K
L
P
N
L
I
Y
H
K
E
I
P
F
Y
-
N
H
L
D
F
I
W
--
A
M
D
A
P
Q
E
V
Y
N
D
I
V
S
M
I
S
E
D
K
K
-----------------------------
42
HHSearch
68.29
16%
-75
- C2 -
-
1U2E
-
MHPC_ECOLI
A:
[25-288]
-------------------------------------------------------------------
L
R
I
H
F
N
D
C
G
------
Q
G
D
E
T
V
V
L
L
H
G
S
G
P
G
A
T
G
W
A
N
---
F
S
R
N
I
D
P
L
V
E
A
G
Y
R
V
I
L
L
D
------------
C
---
P
---
G
W
G
-------
K
S
D
S
V
-----
V
-----
N
S
G
------
S
R
S
D
-
L
N
A
R
I
L
K
S
V
V
D
Q
L
--
D
I
A
K
I
H
L
L
G
N
S
M
G
G
H
S
---
S
V
A
F
T
----
L
K
W
P
----
E
-
R
--
V
G
K
L
V
L
--
M
G
G
G
T
G
G
M
S
L
F
-
T
P
M
P
T
E
------------
G
I
K
R
L
--------------
N
---
Q
----
L
Y
R
Q
P
T
I
E
-----------
N
L
K
L
M
M
D
I
F
-
V
F
D
T
SDL
T
D
--
A
L
F
----
E
------
A
R
L
--
N
N
M
L
S
R
-
R
-----
D
H
---
L
E
N
F
V
K
S
L
-
E
A
N
P
------
K
Q
F
P
D
F
G
P
R
-
L
A
E
I
--
K
A
Q
T
L
I
V
W
G
R
N
D
R
F
V
P
M
D
A
G
L
R
L
L
S
G
I
A
--
G
S
E
L
H
I
F
R
D
C
G
H
W
A
Q
W
E
-----
H
A
D
A
F
N
Q
L
V
L
N
F
L
A
R
--------------------------------
32
HHSearch
67.91
26%
-168
- C2 -
-
5HZ2
1
A:
[5-153]
--------------------------------------------------
G
R
N
V
A
V
T
E
G
A
V
V
F
E
N
E
Y
F
Q
L
L
Q
Y
K
P
L
T
---
D
K
V
H
A
R
P
L
L
M
V
P
P
C
I
N
K
Y
Y
I
L
D
L
Q
-
P
E
S
S
L
V
R
H
V
V
E
Q
G
H
T
V
F
L
V
S
------------
W
---
R
---
N
P
D
-------
A
S
M
A
G
-----
S
-----
T
W
D
------
D
Y
I
E
H
A
A
I
R
A
I
E
V
A
R
D
I
S
--
G
Q
D
K
I
N
V
L
G
F
C
V
G
G
T
I
---
V
S
T
A
L
A
V
L
A
A
R
G
E
----
H
-
P
--
A
A
S
V
T
L
--
L
T
T
L
L
D
F
A
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.02
26%
-188
- C2 -
-
5HZ2
1
A:
[15-157]
------------------------------------------------------------
V
V
F
E
N
E
Y
F
Q
L
L
Q
Y
K
P
L
T
D
---
K
V
H
A
R
P
L
L
M
V
P
P
C
I
N
K
Y
Y
I
L
D
L
Q
-
P
E
S
S
L
V
R
H
V
V
E
Q
G
H
T
V
F
L
V
S
------------
W
---
R
---
N
P
D
-------
A
S
M
A
G
-----
S
-----
T
W
D
------
D
Y
I
E
H
A
A
I
R
A
I
E
V
A
R
D
I
S
--
G
Q
D
K
I
N
V
L
G
F
C
V
G
G
T
I
V
S
T
A
L
A
V
L
----
A
A
R
G
---
E
H
-
P
--
A
A
S
V
T
L
--
L
T
T
L
L
D
F
A
D
T
G
-
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
66.42
26%
-187
- C2 -
-
5T6O
-
A:
[16-168]
------------------------------------------------------------
V
V
F
E
N
E
Y
F
Q
L
L
Q
Y
K
P
L
T
D
---
K
V
H
A
R
P
L
L
M
V
P
P
C
I
N
K
Y
Y
I
L
D
L
Q
-
P
E
S
S
L
V
R
H
V
V
E
Q
G
H
T
V
F
L
V
S
------------
W
---
R
---
N
P
D
-------
A
S
M
A
G
-----
S
-----
T
W
D
------
D
Y
I
E
H
A
A
I
R
A
I
E
V
A
R
D
I
S
--
G
Q
D
K
I
N
V
L
G
F
A
V
G
G
T
I
V
S
T
A
L
A
V
L
----
A
A
R
G
---
E
H
-
P
--
A
A
S
V
T
L
--
L
T
T
L
L
D
F
A
D
T
G
-
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
61.55
14%
-64
- C2 -
-
3OM8
2
?
B:
[7-266]
-----------------------------------------------------------
S
F
L
A
T
S
D
G
A
S
L
A
Y
R
L
D
G
A
-----
A
E
K
P
L
L
A
L
S
N
S
I
G
T
T
L
H
M
W
------
D
A
Q
L
P
A
L
T
-
R
H
F
R
V
L
R
Y
D
------------
A
---
R
---
G
H
G
-------
A
S
S
V
P
P
GP--
Y
-----
T
L
A
------
R
L
G
E
D
V
L
-
E
L
L
D
----
A
L
--
E
V
R
R
A
H
F
L
G
L
S
L
G
G
I
V
---
G
Q
W
L
A
----
L
H
A
P
----
Q
-
R
--
I
E
R
L
V
L
--
A
N
T
S
A
W
L
G
P
A
A
-
Q
W
D
E
-----------------
R
I
-----------
A
------
A
----
V
L
Q
A
E
D
M
S
E
T
A
A
------
G
F
L
G
N
W
F
P
P
A
-
L
L
E
R
---
A
E
--
P
V
V
----
E
------
R
F
R
--
A
M
L
M
A
T
N
R
-----
H
G
---
L
A
G
S
F
A
A
------------
V
R
D
T
D
L
R
A
Q
-
L
A
R
I
--
E
R
P
T
L
V
I
A
G
A
Y
D
T
V
T
A
A
S
H
G
E
L
I
A
A
S
I
A
--
G
A
R
L
V
T
L
P
A
-
V
H
L
S
N
V
E
-----
F
P
Q
A
F
E
G
A
V
L
S
F
L
G
A
--------------------------------
28
Fugue
61.12
12%
-43
- C2 -
-
1AZW
-
PIP_XANCI
A:
[1-313]
-------
M
R
T
L
Y
P
---
E
I
T
P
Y
Q
Q
G
S
L
-
K
V
D
D
----------------------------------------
R
H
T
L
Y
F
E
Q
C
G
N
P
H
G
K
P
V
V
M
L
H
G
G
P
G
G
G
C
-------
N
D
K
M
R
R
F
H
D
P
A
K
Y
R
I
V
L
F
D
------------
Q
---
R
---
G
S
G
-------
R
S
T
P
H
-----
A
-----
D
L
V
------
D
N
T
T
W
D
L
V
A
D
I
E
R
L
R
T
H
L
--
G
V
D
R
W
Q
V
F
G
G
S
W
G
S
T
L
---
A
L
A
Y
A
----
Q
T
H
P
---
Q
Q
----
V
T
E
L
V
L
--
R
G
I
F
L
L
R
R
F
E
L
-
E
W
F
Y
Q
E
G
A
---
S
R
L
-
F
P
D
A
W
E
H
Y
L
-------
N
A
I
P
P
V
E
R
-
A
D
L
-
M
S
A
F
H
R
R
L
T
S
D
D
E
A
-
T
R
L
A
A
A
K
A
W
S
V
W
E
G
A
T
S
F
L
H
---
V
D
--
E
D
F
----
V
T
G
H
E
D
A
H
F
A
--
L
A
F
A
R
I
E
N
-----
H
Y
---
F
V
N
------------
G
G
F
F
E
V
E
D
Q
L
L
R
D
-
A
H
R
I
A-
D
I
P
G
V
I
V
H
G
R
Y
D
V
V
C
P
L
Q
S
A
W
D
L
H
K
A
W
P
K
A
Q
L
Q
I
S
P
-
A
S
-
G
H
--------
S
A
F
E
P
E
N
V
D
A
L
V
R
A
T
D
G
F
A
------------------------------
39
HHSearch
60.83
16%
-39
- C2 -
-
3E0X
1
?
A:
[1-245]
-----------------------------------------------------------------
S
N
A
M
L
H
Y
V
H
V
G
N
----
K
K
S
P
N
T
L
L
F
V
H
G
S
G
C
N
L
K
I
F
------
G
E
L
E
K
Y
L
--
E
D
Y
N
C
I
L
L
D
------------
L
---
K
---
G
H
G
-------
E
S
K
G
Q
CP---
S
-----
T
V
Y
------
G
Y
I
D
N
V
A
-
N
F
I
T
N
S
E
V
T
K
--
H
Q
K
N
I
T
L
I
G
Y
S
M
G
G
A
I
---
V
L
G
V
A
----
L
K
K
L
----
P
-
N
--
V
R
K
V
V
S
--
L
S
G
G
A
R
F
D
K
L
D
-
K
D
--
F
--------------
M
E
K
I
-----------
Y
------
H
---
N
Q
L
D
N
N
--------------
Y
L
L
E
C
I
G
G
I
-
D
N
P
L
---
S
E
--
K
Y
F
----
E
------
T
L
E
--
K
D
P
----------------
D
I
M
I
N
D
L
-
I
A
--------
C
K
L
I
D
L
V
D
N
-
L
K
N
I
--
D
I
P
V
K
A
I
V
A
K
D
E
L
L
T
L
V
E
Y
S
E
I
I
K
K
E
V
E
--
N
S
E
L
K
I
F
E
T
G
K
H
F
L
L
V
V
-----
N
A
K
G
V
A
E
E
I
K
N
F
I
----------------------------------
46
HHSearch
60.06
13%
-74
- C2 -
-
4Q3L
1
?
B:
[22-292]
-----------------------------------------------------------
V
S
I
F
T
Y
Q
E
K
D
I
Y
Y
E
I
D
G
T
---
L
D
I
N
S
D
V
I
V
I
L
N
G
I
M
M
S
T
K
S
W
------
D
A
F
V
E
N
F
S
K
-
N
H
V
L
L
R
Y
D
------------
M
---
F
---
D
Q
G
-------
Q
S
S
K
I
-----
E
ESY--
T
Q
T
------
I
Q
V
-----
E
L
L
K
N
L
L
E
H
L
--
G
I
A
Q
A
N
I
V
G
I
S
Y
G
A
S
I
---
A
L
Q
F
A
----
A
K
Y
P
----
T
-
M
--
I
K
R
M
V
V
--
A
N
V
V
A
K
T
S
P
W
L
-
K
--
D
I
--------------
G
D
G
W
N
-------
E
-
V
A
------
K
T
-
G
N
G
L
A
Y
--
Y
H
I
T
I
P
-
Y
I
Y
S
----
P
Q
F
Y
T
L
---------
H
N
--
D
W
M
----
E
K
R
K
---
E
L
L
--
V
P
L
--
F
S
T
-----------
R
T
F
L
D
R
M
-
I
R
L
T
K
----
S
A
E
T
H
D
V
I
K
D
-
L
P
N
I
--
K
T
P
T
L
I
I
S
S
E
E
D
Y
L
T
P
P
F
E
Q
K
Y
L
Q
E
H
L
Q
--
N
A
E
L
V
S
I
P
N
C
G
H
A
S
M
Y
E
-----
V
P
K
T
F
T
A
L
V
L
G
F
F
G
Q
T
K
------------------------------
45
HHSearch
59.26
13%
-71
- C2 -
-
4Q3L
1
?
G:
[22-292]
-----------------------------------------------------------
V
S
I
F
T
Y
Q
E
K
D
I
Y
Y
E
I
D
G
T
---
L
D
I
N
S
D
V
I
V
I
L
N
G
I
M
M
S
T
K
S
W
------
D
A
F
V
E
N
F
S
K
-
N
H
V
L
L
R
Y
D
------------
M
---
F
---
D
Q
G
-------
Q
S
S
K
I
-----
E
ESY--
T
Q
T
------
I
Q
V
-----
E
L
L
K
N
L
L
E
H
L
--
G
I
A
Q
A
N
I
V
G
I
S
Y
G
A
S
I
---
A
L
Q
F
A
----
A
K
Y
P
----
T
-
M
--
I
K
R
M
V
V
--
A
N
V
V
A
K
T
S
P
W
L
-
K
--
D
I
--------------
G
D
G
W
N
-------
E
-
V
A
------
K
T
-
G
N
G
L
A
Y
--
Y
H
I
T
I
P
-
Y
I
Y
S
----
P
Q
F
Y
T
L
---------
H
N
--
D
W
M
----
E
K
R
K
---
E
L
L
--
V
P
L
--
F
S
T
-----------
R
T
F
L
D
R
M
-
I
R
L
T
K
----
S
A
E
T
H
D
V
I
K
D
-
L
P
N
I
--
K
T
P
T
L
I
I
S
S
E
E
D
Y
L
T
P
P
F
E
Q
K
Y
L
Q
E
H
L
Q
--
N
A
E
L
V
S
I
P
N
C
G
H
A
S
M
Y
E
-----
V
P
K
T
F
T
A
L
V
L
G
F
F
G
Q
T
K
------------------------------
41
HHSearch
56.13
13%
-41
- C2 -
-
5H3H
1
?
B:
[4-269]
------------------------------------------------------------
F
I
Q
A
V
D
G
T
K
I
Y
V
E
D
I
G
-------
S
G
Q
P
V
V
M
L
H
G
W
P
A
N
N
N
M
F
------
E
Y
Q
K
N
R
L
L
E
E
G
Y
R
Y
I
G
V
D
------------
Y
---
R
---
G
Y
G
-------
K
S
D
A
P
-----
A
TGY--
D
Y
T
------
T
M
A
S
D
-----
I
N
E
V
I
Q
Q
L
--
K
L
T
N
V
T
L
L
G
F
S
M
G
G
G
I
---
A
L
K
Y
L
----
L
N
H
G
----
E
S
N
--
V
S
K
L
I
L
--
A
G
A
A
A
P
V
F
T
Q
R
-
D
G
Y
P
Y
----------------
G
M
----------
T
K
------
D
----
E
V
D
A
L
-
I
E
D
T
K
Q
---
D
R
P
S
M
L
K
G
F
G
E
I
F
-
F
A
K
E
---
H
P
--
E
P
L
----
Q
------
Q
W
F
--
H
N
L
S
-
V
D
A
------
S
---
S
H
G
T
I
Q
S
A
-
I
A
--------
L
R
D
E
D
L
R
D
G
-
L
P
K
I
--
T
V
D
T
L
I
M
H
G
K
K
D
Q
V
C
P
F
E
F
A
E
V
M
H
E
N
I
A
--
G
S
R
L
E
V
F
E
E
S
G
H
G
M
F
L
D
-----
E
R
E
K
F
T
E
T
L
V
S
Y
V
K
S
S
-------------------------------
26
Fugue
55.12
17%
2
- C2 -
-
2RAU
7
?
A:
[3-354]
-
Y
E
E
W
K
I
V
K
R
E
A
P
ILG
N
D
Q
L
I
E
N
I
W
K
M
K
R
E
D
-------------------------
S
P
Y
D
I
I
S
L
H
K
V
N
L
I
G
G
G
N
D
A
V
L
I
L
P
G
T
W
S
S
G
E
Q
L
V
T
I
S
W
N
G
V
H
Y
T
I
P
D
-
Y
R
K
S
I
V
L
Y
L
A
R
N
G
F
N
V
Y
T
I
D
YRT---------
H
---
Y
---
V
P
P
-------
F
L
K
D
R
-----
Q
-----
L
S
F
TANWG
W
S
T
W
I
S
D
I
K
E
V
V
S
F
I
K
R
D
S
--
G
Q
E
R
I
Y
L
A
G
E
S
F
G
G
I
A
---
A
L
N
Y
S
----
S
L
Y
W
---
K
N
-
D
--
I
K
G
L
I
L
--
L
D
G
G
P
T
K
H
G
I
R
-
F
Y
T
P
E
V
N
S
---
I
E
E
M
E
A
K
G
I
Y
V
I
P
S
RGGPNN
P
I
W
S
Y
A
L
A
-
N
P
D
M
P
S
P
D
P
K
Y
K
S
I
S
D
F
L
M
D
S
L
Y
V
T
G
S
A
N
P
Y
D
Y
P
-
Y
S
K
K
---
E
D
M
-
F
P
I
----
L
A
S
F
D
P
Y
W
P
Y
------------------------
R
L
S
L
-
E
R
D
L
K
F
D
Y
E
G
I
L
V
P
T
I
A
F
V
-
S
E
R
-------------------
F
G
I
Q
I
F
D
S
K
I
L
P
S
N
S
E
I
I
L
L
K
G
Y
-
G
H
L
D
V
Y
T
--
G
E
N
S
E
K
D
V
N
S
V
V
L
K
W
L
S
Q
Q
R
------------------------------
30
Fugue
53.07
11%
-54
- C2 -
-
4BZW
-
?
A:
[1-275]
-
M
Q
V
E
Q
R
T
L
N
T
A
A
---
H
P
F
Q
I
T
A
Y
W
L
-
D
Q
-----------------------------------------------
I
S
D
F
E
T
A
V
D
Y
P
I
M
I
I
C
P
-
G
G
G
F
T
Y
H
S
G
R
-
E
E
A
P
I
A
T
R
M
M
A
A
G
M
H
T
V
V
L
N
------------
Y
---
Q
---
L
I
V
-------
G
D
Q
S
V
-----
Y
-----
P
W
A
------
L
Q
Q
L
G
A
T
I
D
W
I
T
T
Q
A
S
A
H
HV
D
C
Q
R
I
I
L
A
G
F
S
A
G
G
H
V
---
V
A
T
Y
N
----
G
V
A
T
---
Q
P
-
E
--
L
R
T
R
Y
H
--
L
D
H
Y
Q
G
Q
H
A
A
I
-
I
L
G
--
Y
P
V
---
I
D
L
-
T
A
G
F
P
T
T
----------------------------------
S
A
-
A
R
N
Q
I
T
T
D
A
R
L
W
A
A
Q
-
R
L
V
T
---
P
A
S
K
P
A
F
----
V
W
Q
T
A
T
D
E
S
V
PP
I
N
S
L
K
Y
V
Q
-----
A
M
---
L
Q
H
Q
V
--------
A
T
A
Y
H
L
F
G
S
G
I
H
G
L
A
-
L
A
N
H
--
V
T
Q
-----
K
P
G
K
D
K
Y
L
N
D
Q
A
A
I
W
P
Q
L
A
L
R
W
L
Q
E
Q
G
L
L
A
G
-
N
----------------------------------------------------------
37
HHSearch
53.06
11%
-50
- C2 -
-
2XUA
1
?
H:
[6-264]
-------------------------------------------------------------
Y
A
A
V
N
G
T
E
L
H
Y
R
I
D
G
E
---
R
H
G
N
A
P
W
I
V
L
S
N
S
L
G
T
D
L
S
M
W
------
A
P
Q
V
A
A
L
S
-
K
H
F
R
V
L
R
Y
D
------------
T
---
R
---
G
H
G
-------
H
S
E
A
P
KGP--
Y
-----
T
I
E
------
Q
L
T
G
D
V
L
-
G
L
M
D
----
T
L
--
K
I
A
R
A
N
F
C
G
L
S
M
G
G
L
T
---
G
V
A
L
A
----
A
R
H
A
----
D
-
R
--
I
E
R
V
A
L
--
C
N
T
A
A
R
I
G
S
P
E
-
V
W
--
V
P
---------------
R
A
-----------
V
K
-----
A
R
-
T
E
G
M
H
A
L
-
A
D
A
----------
V
L
P
R
W
F
T
A
D
-
Y
M
E
R
---
E
P
--
V
V
L
----
A
M
I
---
R
D
V
F
--
V
H
---
T
D
K
-----
E
G
---
Y
A
S
N
C
E
A
------------
I
D
A
A
D
L
R
P
E
-
A
P
G
I
--
K
V
P
A
L
V
I
S
G
T
H
D
L
A
A
T
P
A
Q
G
R
E
L
A
Q
A
I
A
--
G
A
R
Y
V
E
L
D
A
-
S
H
I
S
N
I
E
-----
R
A
D
A
F
T
K
T
V
V
D
F
L
T
E
--------------------------------
40
HHSearch
50.74
20%
-113
- C2 -
-
5A62
-
?
A:
[3-127]
-----------------------------------------------------------
F
L
S
S
P
S
N
S
V
S
T
Y
Y
E
D
H
G
D
-----
A
R
S
Y
P
L
V
L
I
H
P
I
G
G
N
I
L
I
W
------
D
Y
E
I
Q
L
L
L
K
S
G
F
R
V
I
A
Y
E
------------
L
---
R
---
G
H
H
-------
R
T
N
M
G
KTGA-
Y
-----
T
M
Q
------
D
L
I
D
D
-----
L
R
R
L
L
E
H
L
--
N
I
G
K
C
T
I
I
G
H
S
I
G
G
I
I
---
S
S
M
Y
A
----
A
Q
H
P
----
G
-
K
--
V
D
A
I
I
M
--
I
N
G
S
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
48.91
14%
-130
- C2 -
-
4JNC
1
A:
[6-127]
-------------------------------------------------------------
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
-------
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
------
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
------------
M
---
K
---
G
Y
G
-------
E
S
S
A
P
-----
P
EIEEY
C
M
E
------
V
L
C
K
-----
E
M
V
T
F
L
D
K
L
--
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
---
V
W
Y
M
A
----
L
F
Y
P
----
E
-
R
--
V
R
A
V
A
S
--
L
N
T
P
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
47.30
30%
-79
- C2 -
-
2RAU
6
?
A:
[83-178]
-----------------------------------------------------------------------------------------------------------
K
S
I
V
L
Y
L
A
R
N
G
F
N
V
Y
T
I
D
------------
Y
---
R
THY
V
P
P
FLKDRQL
S
F
T
A
N
-----
W
-----
G
W
S
------
T
W
I
S
D
-
I
K
E
V
V
S
F
I
K
R
D
S
--
G
Q
E
R
I
Y
L
A
G
E
S
F
G
G
I
A
---
A
L
N
Y
S
----
S
L
Y
W
---
K
N
-
D
--
I
K
G
L
I
L
--
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
46.36
22%
-104
- C2 -
-
5H3H
1
?
A:
[44-133]
-----------------------------------------------------------------------------------------------------------------
L
L
E
E
G
Y
R
Y
I
G
V
D
------------
Y
RGY
G
---
K
S
D
-------
A
P
A
T
G
-----
Y
-----
D
Y
T
------
T
M
A
S
D
-
I
N
E
V
I
Q
Q
L
K
L
------
T
N
V
T
L
L
G
F
S
M
G
G
G
I
---
A
L
K
Y
L
----
L
N
H
G
---
E
S
-
N
--
V
S
K
L
I
L
A
G
A
A
A
P
V
F
T
Q
R
D
G
-
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------