@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKE7: (2017-10-26 )
MEFVFNGFYTLISAVIVLLLGRFLVNRIDFLERYNIPEPVAGGLVAAVVSLLVHTFWGYSIVFSSELQTSFMLVFFASIGLSANFMKLKEGGTALVIFLICVASFIVVQNAVGMSLATLLGLDPLIGLIAGSITLTGGHGTAGAWGEILESQHGIQGALALGMASATFGLIMCVIGGPLAKLLINRYSLAQAKTNAEIQQRDTHVEQNSDDLAPFENPHQVRLITADNAITTLGMFAACLAFAEFMTGFSKGTWFELPTFVWALGGGVILRNILESVLKVDIFDRAIDVFGNASLSLYLAMALLSLKLWQLADLAGPLVVILVAQTLTMALYAAFVTFRVMGKNYDAAVLAASHCGFGMGATPTAVANMQAITNMYGPSHKAFLIVPLCGAFFVDLINATVIQLMLKFIA
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------.........10.--..--.....20.....-----..-.-------30.--.....-.--.40......-----..50-......-------------..60.-..----.-----....70-----...--.-....80-...----.....90-...-.....100-.........110....-...120----.....--...--.130-.--..-.....--.140-.......150...--....-160.....-------------..170-.......180...--....190--------------...---......200.......210......---.220...--....230.....---..240.......250-.-..-...----..260.......270-...-.--...--.280--------..-.......290...-----....300.........310---.....--....320...-....--------------------..330------.-----......-..340----------...----.-...350...-.----...360---.........-370.......--.380------..-..-....390...--....400.......410-----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------ME
F
V
F
N
G
F
Y
T
L
I
--
S
A
--
V
I
V
L
L
L
G
R
F
L
V
N
-----
R
I
-
D
-------
F
L
E
--RYNIP-E--PVA
G
G
L
V
A
A
-----
V
V
S
L
-
L
V
H
T
FW-------------G
Y
S
I
V
-
F
S----S-----EL
Q
T
S
F
-----
M
L
V
--
F
-
F
A
S
IGL-SA
N
----
F
M
K
LKEG-
G
T
A
-
L
V
I
F
L
I
---
C
V
A
S
F
I
V
V
Q
NAV
G
M
S
L
-
A
T
L
L------G
L
D
P
L
--
I
G
L
--IA---G--
S
I
-
T
L
TGG--HGTA-
G
A
W
G
E
I
L
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SQHG
I
--
Q
G
A
L
-
A
L
G
M
A
S
A
T
-------------
F
G
L
I
M
-
C
V
IG
G
P
L
A
K
L
L
I
N
--
R
Y
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LA----------------QAK---TNA
E
I
Q
QRDTHVEQNSDDLAPFENP---
H
Q
V
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L
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T--ADN
A
I
T
T
L
G
M
F
A
---
A
C
L
A
F
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FS-K-G-TW-FEL----
P
T
F
V
W
ALG
G
G
V
I
L
R
--
N
I
L
-
E
--
S
V
L
--
K
V
----------
D
I
-
F
D
R
A
I
D
V
FGN
A
S
L
-----
S
L
Y
L
A
--
M
A
L
L
S
L
K
L
W
Q
-----
L
A
DLA--G
P
L
V
V
--
I
L
V
-
A
Q
T
L
--------------------
T
M
A
--------
L
-----
Y
A
A
F
V
T
-
F
R
VMG----------KNY----
D
-
A
A
V
L
A
A
SHC-G----FGMG-----AT
P
T
A
V
A
N
M
-
Q
-
A
I
T
N
MYGP--SH
K
-------
A
F
-
L
I
-
V
P
L
C
G
A
F
F
V
D
--
L
I
N
A
T
V
I
Q
L
M
L
K
FIA-------
25
Fugue
83.69
19%
-138
- C5 -
-
4BWZ
-
?
A:
[3-386]
--------------------------------------------------------------------------------------------G
A
E
H
L
L
E
I
F
Y
L
L
L
--
A
A
--
Q
V
C
A
F
I
F
K
R
L
-------------------
N
Q
--
P
V
V
I
G
-
E
--
V
L
A
G
V
L
V
G
P
-----
A
L
L
G
-
L
V
H
E
---------------
G
E
I
L
E
-
F
L
----
A
-----
E
L
G
A
V
F
-----
L
L
F
--
M
-
V
G
L
E
T
R
-
L
K
D
----
I
L
A
V
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G
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-
F
L
V
A
V
L
---
G
V
A
L
P
F
L
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G
Y
L
Y
G
L
E
I
-----------
G
F
E
T
L
--
P
A
L
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F
L
---
G
--
T
A
-
L
V
A
T
-----
S
V
-
G
I
T
A
R
V
L
Q
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L
------
G
V
L
-
S
R
P
Y
S
R
I
I
-------------
L
G
A
A
V
-
I
D
D
V
L
G
L
I
V
L
A
C
V
--
N
G
V
A
E
----------------
T
G
Q
---
V
E
V
G
A
I
T
R
L
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L
S
V
V
F
V
G
L
A
V
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---
L
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R
L
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L
--
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R
L
P
V
G
S
P
L
G
F
A
---
L
A
L
G
V
G
M
A
A
L
A
A
S
-
I
-
G
------
L
----
A
P
I
V
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A
F
L
G
G
M
L
L
S
--
E
V
R
-
E
--
K
Y
-------------------
R
L
E
E
P
I
F
A
I
E
S
F
-----
L
A
P
I
F
--
F
A
M
V
G
V
R
L
-
E
-----
L
S
A
L
A
--
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P
V
V
L
--
V
A
G
-
T
V
V
T
--------------------
V
I
A
--------
I
-----
L
G
K
V
L
G
-
G
F
L
G
A
------------
L
----
T
-
Q
G
V
R
S
A
L
T
V
-
G
----
C
G
M
A
-----
P
R
G
E
V
G
L
I
V
-
A
-
A
L
G
L
K
A
G
A
--
V
N
E
-------
E
E
-
Y
A
-
I
V
L
F
M
V
V
F
T
T
--
L
F
A
P
F
A
L
K
P
L
I
A
W
T
E
R
E
R
A
A
K
E
31
Fugue
64.78
22%
-56
- C1 -
-
5L2R
14
?
A:
[64-604]
---------------------------------------------------------------D
F
H
F
S
A
IFQPTDPHHHQ
T
E
F
A
K
VEGSEKY
V
E
E
V
E
V
F
G
R
Q
A
L
K
V
N
P
E
--
A
L
T
I
L
A
H
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A
F
S
D
V
H
H
F
F
R
K
-
D
-------
H
L
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G
W
R
R
A
I
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-
D
--
P
E
A
S
D
N
D
R
Y
-----
V
A
T
T
-
L
L
K
N
A
C
I
A
A
GRVLPSCQDT
G
T
A
I
V
-
L
G
----
K
-----
R
G
E
L
C
W
TGGE
D
E
K
Y
--
L
-
S
K
G
I
W
N
-
A
Y
R
----
Y
H
N
L
R
Y
S
-
Q
T
A
A
L
D
M
F
K
E
---
C
N
T
G
D
---
N
L
P
A
Q
L
D
L
-
L
A
V
P
------
G
S
D
Y
E
--
F
L
F
--
I
A
KG
G
G
--
S
A
-
N
K
A
Y
L
--
Y
Q
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T
-
K
A
L
L
N
P
K
S
L
R
A
F
I
--
E
E
K
L
K
T
L
G
T
A
A
C
P
-------------
P
Y
H
I
A
-
L
V
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G
G
T
S
A
E
M
T
M
K
--
T
V
K
L
A
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C
RYYDSLPTTGDKYG
R
A
F
---
R
D
P
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W
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K
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H
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A
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A
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C
P
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G
L
A
V
---
S
C
S
A
D
R
Q
I
L
A
H
I
N
-
K
S
G
-
I
Y
-
I
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Q
L
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P
A
Q
Y
L
P
T
S
V
K
V
D
L
K
--
R
P
I
-
D
--
K
V
R
--
Q
Q
L
---------
S
Q
-
Y
P
V
G
T
R
V
M
L
N
G
-------
T
L
I
V
A
--
R
D
I
A
H
A
K
I
K
E
-----
M
M
D
N
G
--
E
P
L
P
E
--
Y
M
K
-
T
S
P
I
Y
Y
A
G
P
A
K
TPEGYAS
G
S
F
G
P
T
T
A
G
--------
R
-----
M
D
S
Y
V
D
L
F
Q
S
H
G
GSY
I
T
L
A
K
G
N
R
S
K
----
Q
-
V
T
D
A
C
K
K
H
G
-
G
----
F
Y
L
G
S
IGGP
A
A
I
L
A
K
D
S
I
-
K
-
Q
V
T
C
L
A
F
P
--
E
L
G
ME-----
A
V
-
W
K
-
I
E
V
E
D
F
P
A
F
I
--
V
V
D
D
K
G
N
D
M
Y
S
K
T
L
A
-------
7
HHSearch
63.94
15%
-101
- C5 -
-
5A1S
4
?
D:
[51-443]
---------------------------------------------------------------------------------------------------
L
V
G
G
F
A
--
L
M
--
F
V
M
G
A
I
F
G
E
I
G
K
-----
R
L
-
P
-------
I
F
N
--
K
Y
I
-
G
G
A
--
P
V
M
I
F
L
V
A
A
-----
Y
F
-----
V
Y
A
G
-------------
I
F
T
Q
K
-
E
I
D
A
I
S
N
V
M
DKS
N
F
L
N
L
F
-----
I
A
V
--
L
-
I
T
G
A
I
L
-
S
V
N
----
R
K
L
L
L
K
S
-
L
L
G
-
Y
I
---
P
---
T
I
L
A
G
I
V
G
A
S
L
F
G
I
V
I
-
G
L
C
F
------
G
I
P
V
D
--
R
I
M
--
M
L
---
Y
--
V
L
P
I
M
G
G
G
--
N
G
A
G
A
V
P
L
S
E
I
Y
H
S
V
T
G
R
S
R
E
E
Y
Y
-
S
T
A
I
A
I
L
T
-------------
I
A
N
I
F
A
I
I
F
A
A
L
L
D
M
V
G
K
K
--
Y
T
W
L
S
----------------
G
E
G
---
E
L
V
R
K
------
A
S
------
F
K
T
E
D
D
---
E
K
A
G
Q
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--
H
R
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T
A
V
G
M
V
L
S
T
---
T
C
F
L
L
A
Y
V
V
A
K
K
I
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P
-
S
I
G
G
-
V
S
I
----
H
Y
F
A
W
M
V
L
I
V
A
A
L
N
A
S
G
L
C
-
S
--
P
E
------------------
I
K
A
G
A
K
R
L
S
D
F
F
S
K
QL
L
W
V
L
M
V
G
--
V
G
V
C
Y
T
D
L
Q
E
-----
I
I
D
A
L
--
T
F
A
N
V
--
V
I
A
-
A
I
I
V
--------------------
V
G
A
--------
V
-----
V
G
A
A
I
G
-
G
W
L
I
G
----------
F
Y
P
----
I
-
E
S
S
I
T
A
G
L
C
-
M
----
A
N
R
G
-----
G
S
G
D
L
E
V
L
------
S
A
C
N
R
M
--
N
L
I
-------
S
Y
A
Q
I
-
S
S
R
L
G
G
G
I
V
L
--
V
I
A
S
I
V
F
S
--------------
8
HHSearch
63.44
15%
-109
- C5 -
-
5A1S
3
?
C:
[51-443]
---------------------------------------------------------------------------------------------------
L
V
G
G
F
A
--
L
M
--
F
V
M
G
A
I
F
G
E
I
G
K
-----
R
L
-
P
-------
I
F
N
--
K
Y
I
-
G
G
A
--
P
V
M
I
F
L
V
A
A
-----
Y
F
-----
V
Y
A
G
-------------
I
F
T
Q
K
-
E
I
D
A
I
S
N
V
M
DKS
N
F
L
N
L
F
-----
I
A
V
--
L
-
I
T
G
A
I
L
-
S
V
N
----
R
K
L
L
L
K
S
-
L
L
G
-
Y
I
---
P
---
T
I
L
A
G
I
V
G
A
S
L
F
G
I
V
I
-
G
L
C
F
------
G
I
P
V
D
--
R
I
M
--
M
L
---
Y
--
V
L
P
I
M
G
G
G
--
N
G
A
G
A
V
P
L
S
E
I
Y
H
S
V
T
G
R
S
R
E
E
Y
Y
-
S
T
A
I
A
I
L
T
-------------
I
A
N
I
F
A
I
I
F
A
A
L
L
D
M
V
G
K
K
--
Y
T
W
L
S
----------------
G
E
G
---
E
L
V
R
K
------
A
S
-----------
D
---
E
K
A
G
Q
I
T
--
H
R
E
T
A
V
G
M
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T
---
T
C
F
L
L
A
Y
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V
A
K
K
I
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P
-
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I
G
G
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V
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I
----
H
Y
F
A
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G
L
C
-
S
--
P
E
------------------
I
K
A
G
A
K
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L
S
D
F
F
S
K
QL
L
W
V
L
M
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G
--
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G
V
C
Y
T
D
L
Q
E
-----
I
I
D
A
L
--
T
F
A
N
V
--
V
I
A
-
A
I
I
V
--------------------
V
G
A
--------
V
-----
V
G
A
A
I
G
-
G
W
L
I
G
----------
F
Y
P
----
I
-
E
S
S
I
T
A
G
L
C
-
M
----
A
N
R
G
-----
G
S
G
D
L
E
V
L
------
S
A
C
N
R
M
--
N
L
I
-------
S
Y
A
Q
I
-
S
S
R
L
G
G
G
I
V
L
--
V
I
A
S
I
V
F
S
--------------
34
Fugue
55.20
16%
-85
- C4 -
-
5AB5
-
?
A:
[19-425]
--------------------------------------------------------------------------------------------------------
S
--
Q
V
--
V
R
I
V
G
V
G
R
---
T
-----
G
I
-
G
-------
K
L
H
--
K
-
S
V
D
-
E
--
L
A
A
S
A
L
K
C
A
-----
L
V
D
A
N
M
K
Q
C
D
L
-------------
Q
A
L
I
A
-
V
P
----
S
-----
L
A
S
P
Q
F
-----
M
Q
A
H
H
I
-
A
T
V
A
G
L
-
F
P
T
K
G
K
F
I
V
R
T
V
D
T
-
G
G
A
-
G
P
I
T
A
L
---
G
M
A
V
D
L
V
R
T
R
C
A
--
E
T
-
V
A
V
I
------
A
A
D
A
V
--
L
S
M
--
G
S
---
G
--
A
F
-
A
E
R
S
N
--
A
S
L
R
-
R
S
G
L
P
E
P
C
I
P
H
G
Y
--
D
R
Y
A
-
Q
W
Y
M
S
R
Y
G
-------------
L
K
R
E
Q
-
L
A
M
V
P
V
L
M
S
K
M
A
E
--
R
H
P
E
A
----------------
M
C
Q
K
A
Y
T
L
D
E
V
L
H
S
R
C
V
A
------------
P
---
V
T
N
L
L
E
C
--
A
R
R
A
D
G
A
V
A
L
I
V
---
S
G
--
E
A
H
Y
A
E
H
F
A
-
Q
-
G
-
K
---------
Q
E
Q
R
H
L
G
G
S
K
P
I
I
A
--
S
V
A
-
E
--
A
S
G
--
P
L
FPPGSS----
D
D
-
I
V
P
D
I
F
S
C
R
H
A
A
R
-----
D
A
F
L
S
A
N
L
N
V
G
D
I
H
F
F
G
-----
L
Y
D
C
F
---
P
I
C
L
--
I
Q
A
-
V
E
A
V
--------------------
G
L
C
PEGK
G
G
E
F
M
-----
E
T
A
Y
N
E
-
M
L
N
N
G
----------
G
V
L
----
D
-
P
S
K
F
P
I
N
T
H
-
G
GLQC
F
G
A
P
-----
W
E
V
P
A
M
Y
N
I
-
T
E
A
I
A
Q
L
S
E
E
--
A
G
D
-------
R
Q
-
L
T
P
V
P
K
R
A
L
V
Y
G
N
G
G
I
F
S
A
S
S
V
A
I
L
I
S
D
L
--------
28
Fugue
51.64
14%
-62
- C2 -
-
5MG3
-
SECD_ECOLI
D:
[8-619]
---------------------------------------------------------------------------------------------
M
L
N
R
Y
P
-
L
W
K
Y
V
--
M
L
--
I
V
V
I
V
I
G
L
L
-------------------------
Y
A
L
P
-
N
--
A
-----
V
Q
Q
-----
N
I
N
I
-
L
R
N
R
V
N
-------------
Q
L
G
V
A
-
E
P
----
V
-----
V
Q
R
Q
G
A
-----
D
R
I
--
V
-
V
E
L
P
G
I
Q
D
T
A
----
R
A
K
E
I
L
G
-
A
T
A
-
T
L
E
F
R
L
VNT
N
V
D
Q
A
A
A
A
S
G
R
V
P
G
D
S
-
E
V
K
Q
------
T
R
E
G
Q
--
P
V
V
--
L
Y
---
K
--
R
V
-
I
L
T
G
D
--
H
I
T
D
-
S
T
S
S
Q
D
E
Y
N
Q
P
Q
V
--
N
I
S
L
-
D
S
A
G
G
N
I
M
-------------
S
N
F
T
K
-
D
N
I
G
K
P
M
A
T
L
F
V
E
Y-
K
D
S
G
K
----------------
K
D
A
---
N
G
R
A
V
L
V
K
Q
E
E
V
I
N
I
A
N
I
Q
S
R
L
G
N
S
---
F
R
I
T
G
I
N
--
N
P
N
E
A
R
Q
L
S
L
L
L
---
R
A
G
A
L
I
A
P
I
Q
I
V
E
-
E
-
R
-
T
I
G
P
T
L
----
G
M
Q
N
I
E
Q
G
L
E
A
C
L
A
--
G
L
L
-
V
--
S
I
L
--
F
M
----------
I
I
-
F
Y
K
K
F
G
L
I
A
T
S
A
L
-----
I
A
N
L
I
--
L
I
V
G
I
M
S
L
L
P
GATLS
M
P
G
I
A
--
G
I
V
L
T
--
L
A
V
-
A
V
D
A
--------------------
N
V
L
--------
I
-----
N
E
R
I
K
E
-
E
L
S
N
G
----------
R
T
V
----
Q
-
Q
A
I
D
E
G
Y
R
G
-
A
----
F
S
S
I
-----
F
D
A
N
I
T
T
L
I
-
K
-
V
I
I
L
Y
A
V
G
TG
A
I
K
-------
G
F
-
A
I
-
T
T
G
I
G
V
A
T
S
M
--
F
T
A
I
V
G
T
R
A
I
V
N
L
L
Y
GGKRVKK
30
Fugue
48.43
20%
-31
- C3 -
-
5KVM
8
AGRG1_MOUSE
A:
[1-355]
---------------------------------------------------------------------------------PRED
F
R
F
C
G
Q
R
N
Q
T
Q
Q
S
T
L
H
Y
D
Q
S
--
S
E
P
H
I
F
V
W
N
T
E
E
T
L
T
I
-----
R
A
-
P
-------
F
L
A
--
A
P
D
I
P
-
R
FF
P
E
P
R
G
L
Y
H
F
-----
C
L
Y
W
-
S
R
H
T
-
G
-------------
R
L
H
L
R
-
Y
G
------------
K
H
D
Y
-----
L
L
S
--
S
-
Q
A
S
R
L
L
---
C
----
F
Q
K
Q
E
Q
---------------------------------
S
L
K
------
Q
G
A
P
L
--
I
A
T
--
S
V
---
S
--
S
W
-
Q
I
P
Q
N
--
T
S
L
P
-
G
A
-
P
S
F
I
F
S
F
H
N
A
--
P
H
K
V
-
S
H
N
A
S
V
D
------------------
M
-
C
D
L
K
K
E
L
Q
Q
L
--
S
--
R
Y
L
Q
H
----------------
P
Q
K
---
A
A
K
R
----------------
P
T
A
A
F
---
I
S
Q
Q
L
Q
S
--
L
E
S
K
L
T
S
V
S
F
L
G
---
D
T
L
S
F
E
E
D
--------------
R
V
----
N
A
T
V
W
K
L
P
P
T
A
G
L
E
--
D
L
H
-
I
--
H
S
Q
--
K
E
----------
E
-------
E
Q
S
E
V
Q
A
Y
-----
S
L
L
L
P
--
R
A
V
F
Q
Q
T
R
G
R
-----
R
R
D
D
A
--
K
R
L
L
V
--
V
D
F
S
S
Q
A
L
FQDKNS--------------
S
Q
V
--------
L
-----
G
E
K
V
L
G
-
I
V
V
Q
N
----------
T
K
V
T
NLS
D
-
P
V
V
L
T
F
Q
H
----------
Q
-----
P
Q
P
K
N
V
T
L
Q
C
V
-
F
W
V
E
D
P
A
S
--
S
S
T
-------
G
S
-
W
S
-
S
A
G
C
E
T
V
S
R
D
--
T
Q
T
S
C
L
C
N
H
L
------------
26
Fugue
47.36
13%
-54
- C5 -
-
4WBD
3
BSHC_BACSU
A:
[2-541]
H
M
Q
L
T
E
L
S
I
K
N
QN
V
F
V
Q
H
Y
I
D
GKEEMSSFFDYSIHHKD
M
W
R
E
R
L
E
D
L
S
S
RFFA
R
E
E
L
A
A
Y
L
T
S
Y
H
NKFGS
S
A
M
Q
S
A
I
E
K
L
K
DPS
S
A
A
V
V
G
GQQ
A
G
L
L
T
G
P
L
Y
T
I
H
--
K
I
--
I
S
I
I
V
L
A
K
Q
Q
E
K
-----
E
L
-
Q
V
P
V
I
P
I
F
W
V
A
--
G
E
D
H
D
-
L
--
D
E
I
N
F
V
H
T
S
E
EN
G
P
V
K
K
K
-
L
P
Q
S
Y
W
-------------
K
K
S
S
A
-
A
S
----
T
-----
S
L
D
Q
E
K
-----
C
A
A
--
W
-
I
D
D
V
F
A
-
A
------
F
E
E
T
D
H
T
-
N
T
L
-
L
D
N
V
K
R
---
C
L
R
E
S
V
T
F
T
D
F
F
E
L
L
I
-
A
D
L
F
------
Q
E
E
G
L
--
V
L
L
--
N
S
---
G
--
D
P
-
G
I
K
----
K
L
E
T
-
A
M
F
Q
K
I
L
R
E
N
D
E
L
--
A
R
A
V
-
S
D
Q
Q
A
F
M
R
Q
A
G
Y
K
P
I
IESGKE
Q
A
N
L
F
-
Y
E
Y
E
D
E
R
F
L
I
E
K
D
NG
R
F
V
I
K
----------------
E
L
D
---
L
G
W
T
R
D
E
L
H
T
H
M
E
E
H
P
E
R
---
F
S
N
N
---
V
V
T
R
P
L
M
--
Q
E
F
L
I
P
T
L
A
F
I
A
G
P
G
E
I
N
Y
W
G
E
L
K
Q
A
F
A
-
V
---
M
G
-
F
K
M
----
P
P
V
M
P
R
L
N
I
T
I
L
E
R
--
H
I
E
-
K
--
K
L
A
--
E
R
----------
N
I
S
L
Q
D
A
I
E
R
G
T
E
N
Q
R
-----
E
T
Y
F
E
--
R
Q
I
-
P
E
E
F
T
A
-----
V
M
D
Q
A
--
K
S
Q
I
E
--
A
I
H
-
K
T
V
R
--------------------
Q
E
A
--------
L
K
V
DQS
L
E
P
L
L
L
-
K
N
A
A
F
----------
I
Q
D
----
Q
-
L
Q
F
L
E
R
T
V
M
-
K
----
R
I
E
E
-----
K
E
G
Y
V
L
K
D
Y
-
E
-
R
I
Q
N
S
I
K
P
--
L
L
A
PQERIWN
I
M
-
Y
Y
-
L
N
R
Y
G
P
K
F
F
T
--
T
F
K
N
L
P
F
S
F
Q
N
Q
H
Q
V
V
K
L----
12
HHSearch
37.23
16%
-129
- C5 -
-
5A1S
2
?
C:
[269-445]
----------------------------------------------------------------------------------------------------
A
V
G
M
V
--
L
S
--
T
T
C
F
L
L
A
Y
V
V
A
K
-----
K
I
L
P
-------
S
I
G
--
G
V
S
I
H
-
Y
--
F
A
W
M
V
L
I
V
A
-----
A
L
-----
N
A
S
G
-------------
L
C
S
P
E
I
K
A
G
A
--
K
-----
R
L
S
D
F
F
S
K
QL-
L
W
V
--
L
-
M
V
G
V
G
V
C
Y
T
D
----
L
Q
E
I
I
D
A
L
T
F
A
-
N
V
---
V
---
I
A
A
I
I
V
V
G
A
V
V
G
A
A
I
G
-
G
W
L
I
------
G
F
Y
P
I
--
E
S
S
--
I
T
---
A
GL
C
M
-
A
N
R
G
G
--
S
G
D
L
-
E
V
L
S
---
A
C
-
N
-
R
--
M
N
L
I
-
S
Y
A
Q
I
S
S
R
-------------
L
G
G
G
I
V
L
V
I
A
S
I
V
F
S
M
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
37.22
17%
-215
- C5 -
-
4D0A
-
NAH1_METJA
B:
[14-135]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
L
G
S
L
V
A
K
I
A
-
E
----
K
-
L
K
I
----
P
D
I
P
L
L
L
L
L
G
L
I
I
G
--
P
F
L
-
Q
--
I
I
P
--
S
-----------
D
S
-
A
M
E
I
F
E
Y
A
G
P
I
G
L
-----
I
F
I
L
L
--
G
G
A
F
T
M
R
I
S
L
-----
L
K
R
V
I
--
K
T
V
V
R
--
L
D
T
-
I
T
F
L
--------------------
I
T
L
--------
L
-----
I
S
G
F
I
F
-
N
M
V
L
N
----------
L
P
Y
----
T
S
P
V
G
Y
L
---
F
-
G
----
A
I
T
A
-----
A
T
D
P
A
T
------------------------------------------------------------------
13
HHSearch
36.42
16%
-121
- C5 -
-
5A1S
4
?
D:
[269-445]
----------------------------------------------------------------------------------------------------
A
V
G
M
V
--
L
S
--
T
T
C
F
L
L
A
Y
V
V
A
K
-----
K
I
L
P
-------
S
I
G
--
G
V
S
I
H
-
Y
--
F
A
W
M
V
L
I
V
A
-----
A
L
-----
N
A
S
G
-------------
L
C
S
P
E
I
K
A
G
A
--
K
-----
R
L
S
D
F
F
S
K
QL-
L
W
V
--
L
-
M
V
G
V
G
V
C
Y
T
D
----
L
Q
E
I
I
D
A
L
T
F
A
-
N
V
---
V
---
I
A
A
I
I
V
V
G
A
V
V
G
A
A
I
G
-
G
W
L
I
------
G
F
Y
P
I
--
E
S
S
--
I
T
---
A
GL
C
M
-
A
N
R
G
G
--
S
G
D
L
-
E
V
L
S
---
A
C
-
N
-
R
--
M
N
L
I
-
S
Y
A
Q
I
S
S
R
-------------
L
G
G
G
I
V
L
V
I
A
S
I
V
F
S
M
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
36.31
17%
-204
- C5 -
-
4CZB
-
NAH1_METJA
A:
[14-135]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
L
G
S
L
V
A
K
I
A
-
E
----
K
-
L
K
I
----
P
D
I
P
L
L
L
L
L
G
L
I
I
G
--
P
F
L
-
Q
--
I
I
P
--
S
-----------
D
S
-
A
M
E
I
F
E
Y
A
G
P
I
G
L
-----
I
F
I
L
L
--
G
G
A
F
T
M
R
I
S
L
-----
L
K
R
V
I
--
K
T
V
V
R
--
L
D
T
-
I
T
F
L
--------------------
I
T
L
--------
L
-----
I
S
G
F
I
F
-
N
M
V
L
N
----------
L
P
Y
----
T
S
P
V
G
Y
L
---
F
-
G
----
A
I
T
A
-----
A
T
D
P
A
T
------------------------------------------------------------------
18
HHSearch
34.24
17%
-158
- C5 -
-
4CZ8
2
?
A:
[28-134]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
----
S
Y
V
P
I
F
I
L
T
G
L
V
I
G
--
P
L
L
-
K
--
L
I
P
--
R
D
-----------
L
-
A
H
E
I
F
D
F
V
R
V
F
G
L
-----
V
I
I
L
F
--
T
E
G
H
N
L
S
W
R
L
-----
L
K
K
N
M
--
P
T
I
V
T
--
L
D
T
-
I
G
L
I
--------------------
L
T
A
--------
L
-----
I
A
G
F
I
F
-
K
V
V
F
N
----------
S
S
F
----
L
-
L
G
F
-
L
---
F
-
G
----
A
I
I
G
-----
A
T
D
P
A
T
L
-----------------------------------------------------------------
1
PsiBlast_PDB
33.28
44%
-52
- C6 -
-
2LT2
-
?
A:
[31-57]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
--
V
H
L
-
E
--
K
T
S
--
E
I
----------
D
V
-
F
D
R
A
M
D
V
F
H
N
L
K
M
-----
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
33.03
44%
-56
* C6 *
-
2MPB
-
?
A:
[31-57]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
--
V
H
L
-
E
--
K
T
S
--
E
I
----------
D
V
-
F
D
R
A
M
D
V
F
H
N
L
K
M
-----
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
32.32
22%
-165
- C5 -
-
5BZ3
2
?
A:
[233-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
----
A
P
I
V
G
A
F
L
G
G
M
L
L
S
--
E
V
R
-
E
--
K
Y
R
---------------
L
-
E
E
-
P
I
F
A
I
E
S
F
L
A
-----
P
I
F
F
A
--
M
V
G
V
R
L
E
L
S
A
-----
L
A
S
P
V
V
L
V
A
G
T
V
--
V
T
V
-
I
A
I
L
--------------------
G
K
V
--------
L
-----
G
G
F
L
G
A
-
L
T
-
Q
-----------
G
V
R
----
S
-
A
L
T
V
G
---
C
G
M
----
A
P
R
G
-----
E
V
G
L
I
V
A
A
L
---------------------------------------------------------------
24
HHSearch
32.29
17%
-158
- C5 -
-
1ZCD
-
NHAA_ECOLI
A:
[18-175]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
I
A
A
I
L
A
M
I
M
A
--
N
S
G
A
T
S
G
W
Y
H
D
F
L
E
T
P
V
Q
L
R
V
GS
L
E
I
-
N
K
N
M
L
L
W
I
N
D
A
L
M
-----
A
V
F
F
L
--
L
V
G
L
E
V
K
R
E
L
M
QGS-
L
A
S
L
R
--
Q
A
A
F
P
V
I
A
A
I
-
G
G
M
I
--------------------
V
P
A
--------
L
-----
L
Y
L
A
F
N
-
Y
---
A
-----------
D
P
----
I
-
T
R
----
E
G
W
-
A
----
I
P
-
A
-----
A
T
D
I
A
F
A
L
G
-
V
-
L
A
L
L
G
S
R
---
V
P
L
-------
A
L
-
K
I
-
F
L
M
A
L
A
I
I
D
D
--
L
G
A
I
I
I
I
A
L
F
Y
-----------
23
HHSearch
31.12
18%
-193
- C5 -
-
3ZUX
6
?
A:
[7-109]
----------------------------------------------------------------------------------------------------------------------
N
I
L
S
K
-----
I
S
-
S
-------
F
I
G
--
K
T
F
S
L
-
W
---
A
A
L
F
A
A
A
A
-----
F
--
F
-
A
P
D
T
F
K
-------------
W
A
----------
G
-----
P
Y
I
P
W
L
-----
L
G
I
--
I
-
M
F
G
M
G
L
-
T
L
K
----
P
S
D
F
D
I
L
-
F
K
H
-
P
K
V
V
I
I
---
G
V
I
A
Q
F
A
I
M
P
A
T
A
W
C
L
-
S
K
L
L
------
N
L
P
A
E
I
A
V
G
V
--
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
30.21
18%
-136
- C5 -
-
1ZCD
-
NHAA_ECOLI
A:
[260-384]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
L
I
-----
L
P
L
--
F
A
F
A
N
A
G
V
-
S
L
Q
----
G
V
T
L
D
G
L
-
T
S
I
---
L
P
L
G
---
I
I
A
G
L
L
I
G
K
-
P
L
G
I
S
L
F
C
W
L
A
LRLKLA
H
L
P
E
G
--
T
T
Y
Q
Q
I
M
---
V
---
V
-
G
I
L
C
G
IG
F
T
M
S
-
I
F
I
A
S
L
A
F
G
-
S
V
D
--
P
E
L
I
-
N
W
A
K
L
G
I
L
-------------
V
G
S
I
S
S
A
V
I
G
Y
S
W
L
R
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
30.01
17%
-185
- C5 -
-
3ZUY
5
?
A:
[3-104]
-----------------------------------------------------------------------------------------------------------------------
I
L
S
K
-----
I
S
-
S
-------
F
I
G
--
K
T
F
S
L
-
W
--
A
A
L
F
-
A
A
A
A
-----
F
--
F
-
A
P
D
T
F
K
-------------
W
------
A
----
G
-----
P
Y
I
P
W
L
-----
L
G
I
--
I
-
M
F
G
M
G
L
-
T
L
K
----
P
S
D
F
D
I
L
-
F
K
H
-
P
K
V
V
I
I
---
G
V
I
A
Q
F
A
I
M
P
A
T
A
W
L
L
-
S
K
L
L
------
N
L
P
A
E
I
A
V
G
V
--
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------