@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKF1: (2017-10-26 )
MRTSEKQVKPIEIDDINIIENEKTKKAITAAALGNAIEWFDFGVYGYVAYVLGKVFFPDASPSVQMIAALATFSVPFIFRPLGGLFFGHLGDKYGRQKVLAITVIIMSISTFGIGLIPSYETIGLWAPILLLIVKIVQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAATVALITHAVGEARFAEWGWRIPFFLALPLGIIGLYLRNRLEETPVYQQHSEQQAQKSKPQKFSFKEIFVKHKRSLLVCIGLVISTNVTYYMLLTYLPSYFSHNLGYSEAHGALIIIAVMVGMLFVQPVIGYLSDKFGRRPFIFIGSFSLIFLSYPAFVLLNSGVNYQIFIGLLILALSLNMSIGVMASTLPALFPTEIRYSALGIAFNFSVVIAGLTPTLTATLVETTHNLMVPAYYLMICGVVGIATAMYLKETANKPLIGGVPIAHNIEEAQELLEEFHETIEQKIENIDQKIQELQQKRQKLADKHPDIA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60--........70....--.--...80........90........100.......110....---.--------..120--------....---------...-------..130------........140.......150.......160.......170.......180..--.....190.------......----200...-....210.....-.-.----------------------220......------.230---......----------------------------.----.------------240----........----.-250-..--..----------------------.....--------260....--------....-270..-.....280...-....290--------....---.....300.......310......--.320.......330--..--....-.-.340.-.---.----.----.-....350.......360--...-.-.-...370..-.....380.......------390....-...400.......410...--..---..420.......430..----.....440.......450.......460.......470.......480.......490...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRTSEKQVK
P
I
EID
D
I
N
I
IENE
K
T
K
K
A
I
T
A
A
A
LGN
A
I
E
W
F
D
F
G
V
Y
G
Y
V
A
Y
V
L
G
K
VFFPDAS--P
S
V
Q
M
I
A
A
L
A
T
FS
V
--
P
--
F
I
F
R
P
L
G
G
L
F
F
G
H
L
G
D
KYGR
Q
K
V
L
A
I
T
V
I
I
M
S
ISTF
G
I
GL---I--------PS
Y
----------
E
T
I
G
---------
L
W
A
-------
P
I
L
L
-------
L
I
V
K
I
V
Q
GFSIGGEYS
G
A
A
I
F
V
AEYSP
D
R
KRGFMGSWL
D
F
G
S
I
A
G
F
V
L
G
A
A
T
V
--
A
L
I
T
H
A
VGE------
A
R
F
A
EW----GWRI
P
F
-
F
L
A
L
P
L
G
I
I
G
L
Y
-
L
-
R
----------------------
N
R
LEETP
V
Y
------
Q
Q
H
----
S
E
Q
Q
A
Q
----------------------------K----S------------K------PQKF
S
F
K
E
----
I
-
F
---
V
K
--
H
K
----------------------
R
S
L
L
V
--------
C
-
I
G
L
V
I--------STN
V
-
T
Y
Y
M
L
-
L
T
Y
L
P
S
Y
F
SHN-LGYSE----------AH
G
A
---
L
I
I
I
A
V
M
V
G
M
L
F
V
Q
P
V
I
G
Y
L
S
D
KF--GRR
P
F
I
F
IGS
F
S
L
---
I
F
--LSY
P
-
A
-
F
V
--
L
-L---N----S----G-V
N
Y
Q
I
F
I
G
L
L
I
L
A
L
SL---NMS-I-
G
-
V
M
A
S
T
L
P
A
-LFPTE
I
R
Y
S
A
L
G
I
A
F
------
N
F
S
V
V
IA-GLT
P
T
L
T
A
T
L
V
E
TTHN
L
M
V
--
P
A
---
Y
Y
L
M
I
C
G
V
V
G
I
A
T
A
M
Y
L
----
K
E
TANKPLIGGVPIAH
N
I
E
E
A
Q
E
L
L
E
E
F
H
E
T
I
E
Q
K
I
E
N
I
D
Q
K
I
Q
E
L
Q
Q
K
R
Q
K
L
A
DKHPDIA
3
PsiBlast_PDB
78.65
23%
-111
- C2 -
-
4GC0
5
XYLE_ECOLI
A:
[17-479]
------------------------------
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
--
L
S
E
S
A
A
N
S
L
L
G
F
C
V
--
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
--
G
V
G
-------------
S
A
W
----------
P
E
L
G
---------
F
T
S
INPDNTV
P
V
Y
L
AGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
----
V
--
Y
C
V
N
Y
F
I
A
R
------
S
G
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
-
A
S
E
C
I
P
A
L
L
F
L
M
-
L
-
L
----------------------
Y
T
V
P
E
S
P
R
W
L
M
S
R
GK
Q
E
Q
----
A
E
G
I
L
R
----------------------------
K
----
I
------------
M
------
G
N
T
L
A
T
Q
A
----
V
Q
E
---
I
K
--
H
S
L
D
H
G
R
K
T
G
G
-------------
R
L
L
M
F
--------
G
-
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
-
G
I
N
V
V
-
L
Y
Y
A
P
E
V
F
-
K
T
-
L
G
A
S
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
--
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
--
S
L
G
T
-
A
-
F
Y
--
T
-
Q
---
A
----
P
----
G
-
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
---
A
M
S
-
W
-
G
P
V
C
W
V
L
L
S
E
-
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
-
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
------
G
---
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
KFV
P
E
T
K
G
K
T
L
----------
E
E
L
E
A
L
W
E
-----------------------------------
2
PsiBlast_PDB
77.89
23%
-109
- C2 -
-
4GBZ
5
XYLE_ECOLI
A:
[17-479]
------------------------------
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
--
L
S
E
S
A
A
N
S
L
L
G
F
C
V
--
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
--
G
V
G
-------------
S
A
W
----------
P
E
L
G
---------
F
T
S
INPDNTV
P
V
Y
L
AGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
----
V
--
Y
C
V
N
Y
F
I
A
R
------
S
G
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
-
A
S
E
C
I
P
A
L
L
F
L
M
-
L
-
L
----------------------
Y
T
V
P
E
S
P
R
W
L
M
S
R
GK
Q
E
Q
----
A
E
G
I
L
R
----------------------------
K
----
I
------------
M
------
G
N
T
L
A
T
Q
A
----
V
Q
E
---
I
K
--
H
S
L
D
H
G
R
K
T
GG-------------
R
L
L
M
F
--------
G
-
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
-
G
I
N
V
V
-
L
Y
Y
A
P
E
V
F
-
K
T
-
L
G
A
S
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
--
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
--
S
L
G
T
-
A
-
F
Y
--
T
-
Q
---
A
----
P
----
G
-
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
---
A
M
S
-
W
-
G
P
V
C
W
V
L
L
S
E
-
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
-
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
------
G
---
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
KFV
P
E
T
K
G
K
T
L
----------
E
E
L
E
A
L
W
E
-----------------------------------
1
PsiBlast_PDB
77.81
23%
-109
- C2 -
-
4GBY
5
XYLE_ECOLI
A:
[17-479]
------------------------------
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
--
L
S
E
S
A
A
N
S
L
L
G
F
C
V
--
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
--
G
V
G
-------------
S
A
W
----------
P
E
L
G
---------
F
T
S
INPDNTV
P
V
Y
L
AGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
----
V
--
Y
C
V
N
Y
F
I
A
R
------
S
G
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
-
A
S
E
C
I
P
A
L
L
F
L
M
-
L
-
L
----------------------
Y
T
V
P
E
S
P
R
W
L
M
S
R
GK
Q
E
Q
----
A
E
G
I
L
R
----------------------------
K
----
I
------------
M
------
G
N
T
L
A
T
Q
A
----
V
Q
E
---
I
K
--
H
S
L
D
H
G
R
K
T
G
G
-------------
R
L
L
M
F
--------
G
-
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
-
G
I
N
V
V
-
L
Y
Y
A
P
E
V
F
-
K
T
-
L
G
A
S
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
--
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
--
S
L
G
T
-
A
-
F
Y
--
T
-
Q
---
A
----
P
----
G
-
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
---
A
M
S
-
W
-
G
P
V
C
W
V
L
L
S
E
-
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
-
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
------
G
---
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
KFV
P
E
T
K
G
K
T
L
----------
E
E
L
E
A
L
W
E
-----------------------------------
26
Fugue
73.05
22%
-112
- C2 -
-
4QIQ
-
XYLE_ECOLI
A:
[7-470]
---------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
--
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
--
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
---
P
ELGFTSIN
P
D
N
----------
T
V
P
V
---------
Y
L
A
GY-----
V
P
E
F
-------
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
--
Y
F
I
A
R
S
G
D
A
------
S
W
L
N
T
D
----
G
W
R
Y
M
F
-
A
S
E
C
I
P
A
L
L
F
L
M
-
L
-
L
----------------------
Y
T
V
P
E
S
P
R
W
------
L
M
T
----
L
A
T
Q
A
V
----------------------------
Q
----
E
------------
I
------
K
H
S
L
D
R
L
L
----
M
-
F
---
G
V
--
G
V
----------------------
I
V
I
G
V
--------
M
-
L
S
I
F
Q
--------
Q
F
-
V
-
G
I
N
V
V
-
L
Y
Y
A
P
E
V
F
-
K
T
-
L
G
A
S
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
--
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
--
G
M
F
S
L
G
-
T
A
--
F
-
Y
---
T
----
Q
----
A
-
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
---
A
M
S
-
W
-
G
P
V
C
W
V
L
L
S
E
-
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
------
A
-
A
Q
W
L
A
-
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
--
H
F
HNG
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
----
W
K
F
V
P
E
T
-----------------------------------------
K
G
K
T
L
--------
23
Fugue
71.34
19%
-127
- C2 -
-
4GC0
5
XYLE_ECOLI
A:
[5-479]
------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
--
L
S
E
S
A
A
N
S
L
L
G
F
C
V
--
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
P--
E
--------
L
G
F
----------
T
S
I
N
PDNTVPVYL
A
G
Y
-------
V
P
E
F
-------
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
--
Y
F
I
A
R
S
G
D
A
------
S
W
L
N
T
D
----
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
-
Y
T
VPES
P
R
W
L
M
S
R
GK
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
------
T
Q
A
----
V
Q
E
I
K
H
----------------------------
S
----
L
------------
D
------
H
G
R
K
T
G
G
R
----
L
-
L
---
M
F
--
G
V
----------------------
G
V
I
V
I
--------
G
-
V
M
L
S
I
--------
F
Q
Q
F
-
V
G
I
N
V
-
V
L
Y
Y
A
P
E
V
F
K
T
-
L
G
A
S
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
--
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
G
-
M
F
S
L
-
G
-
T
A
--
F
-
Y
---
T
----
Q
----
A
-
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
---
A
M
S
-
W
-
G
-
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
------
A
A
Q
W
L
A
N
-
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
FH
N
G
---
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
----
W
K
F
V
P
------------------------
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-----------------
32
HHSearch
69.10
22%
-111
- C2 -
-
4GC0
4
XYLE_ECOLI
A:
[12-429]
-------------------------
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
LS
E
S
A
A
N
S
L
L
G
F
C
V
A
S
--
A
--
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
---
P
--------
E
L
G
FTSINPDNTV
P
V
Y
L
---------
A
G
Y
-------
V
P
E
F
-------
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
--
Y
F
I
A
R
S
G
D
A
------
S
W
L
N
T
D
----
G
W
R
Y
M
F
-
A
S
E
C
I
P
A
L
L
F
L
M
-
L
-
L
----------------------
Y
T
V
P
E
S
P
R
W
------
L
M
S
----
R
G
K
Q
E
Q
----------------------------
A
----
E
G
I
L
R
K
I
MG
N
T
L
A
T
------
Q
A
V
Q
E
I
K
H
----
S
-
L
D
H
G
R
K
--
T
G
----------------------
G
R
L
L
M
F
GVG
V
I
V
I
G
V
M
L
S
I
F
--------
Q
Q
F
V
-
G
I
N
V
V
-
L
Y
Y
A
P
E
V
F
K
-
T
-
L
G
A
S
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
--
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
---
G
M
F
-
S
-
L
G
--
T
-
A
F
--
Y
T
---
Q
A---
P
-
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
---
M
S
W
-
G
-
P
-
V
C
W
V
L
L
S
E
-
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
------
A
A
Q
W
L
A
N
-
Y
F
V
S
W
T
F
P
M
M
--------------------------------------------------------------------------------------------------
31
HHSearch
69.01
22%
-113
- C2 -
-
4GBY
4
XYLE_ECOLI
A:
[12-429]
-------------------------
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
LS
E
S
A
A
N
S
L
L
G
F
C
V
A
S
--
A
--
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
---
P
--------
E
L
G
FTSINPDNTV
P
V
Y
L
---------
A
G
Y
-------
V
P
E
F
-------
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
--
Y
F
I
A
R
S
G
D
A
------
S
W
L
N
T
D
----
G
W
R
Y
M
F
-
A
S
E
C
I
P
A
L
L
F
L
M
-
L
-
L
----------------------
Y
T
V
P
E
S
P
R
W
------
L
M
S
----
R
G
K
Q
E
Q
----------------------------
A
----
E
G
I
L
R
K
I
MG
N
T
L
A
T
------
Q
A
V
Q
E
I
K
H
----
S
-
L
D
H
G
R
K
--
T
G
----------------------
G
R
L
L
M
F
GVG
V
I
V
I
G
V
M
L
S
I
F
--------
Q
Q
F
V
-
G
I
N
V
V
-
L
Y
Y
A
P
E
V
F
K
-
T
-
L
G
A
S
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
--
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
---
G
M
F
-
S
-
L
G
--
T
-
A
F
--
Y
T
---
Q
A---
P
-
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
---
M
S
W
-
G
-
P
-
V
C
W
V
L
L
S
E
-
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
------
A
A
Q
W
L
A
N
-
Y
F
V
S
W
T
F
P
M
M
--------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.56
24%
-116
- C2 -
-
4JA4
-
XYLE_ECOLI
A:
[17-417]
------------------------------
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
--
L
S
E
S
A
A
N
S
L
L
G
F
C
V
--
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
--
G
V
G
-------------
S
A
W
----------
P
E
L
G
---------
F
T
S
I
N
P
D
N
T
V
P
V
Y
L
AGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
----
V
--
Y
C
V
N
Y
F
I
A
R
------
S
G
D
A
S
W
L
N
T
D
G
W
R
Y
M
F
-
A
S
E
C
I
P
A
L
L
F
L
M
-
L
-
L
----------------------
Y
T
V
P
E
S
P
R
W
LM----
Q
E
Q
----
A
E
G
I
L
R
----------------------------
K
----
I
------------
M
------
G
N
T
L
A
T
Q
A
----
V
Q
E
---
I
K
--
H
S
L
D
H
G---------------------
M
F
--------
G
-
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
-
G
I
N
V
V
-
L
Y
Y
A
P
E
V
-----------------------
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
--
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
--
S
L
G
T
-
A
-
F
Y
--
T
-
Q
---
A
----
P
----
G
-
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
---
A
M
S
-
W
-
G
P
V
C
W
V
L
L
S
E
-
I
F
P
N
A
I
R
G
K
A
L
A
I
A
---------------------------------------------------------------------------------------------------------------------------
35
HHSearch
63.34
21%
-
- C2 -
-
4LDS
-
?
A:
[8-399]
--------------------------
I
F
I
L
G
A
L
G
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
H
K
D
I
P
--
L
N
--
S
-
T
T
E
G
I
---
V
V
S
S
--
M
--
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
L
I
L
A
A
---
S
--------
T
N
L
----------
A
------------------------
L
L
-------
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
--
Y
A
F
A
D
--------------
I
E
----
G
W
R
W
M
L
-
G
L
A
V
V
P
S
V
I
L
L
V
-
G
-
I
----------------------
Y
F
M
P
E
S
P
R
W
------
L
L
E
----
N
R
N
E
E
A
A
R
Q
V
M
K
I
T
YDDSE
I
--------------
D
K
---
E
L
-----------
K
E
M
K
E
I
N
A
I
S
E
S
T
W
T
----
V
-
I
---
K
S
--
P
W
L
G
--------------------
R
I
L
I
V
--------
G
-
C
I
F
A
I
--------
F
Q
Q
F
I
G
I
N
A
V
-
I
F
Y
S
S
S
I
F
-
A
K
-
A
G
L
G
E
----------
A
A
S
I
---
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
--
D
R
K
K
L
L
V
G
G
N
I
G
M
---
I
A
--
S
L
L
I
-
M
A
I
L
I
W
T
-
I
G--
I
----
A
----
S
-
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
---
G
I
S
-
W
G
P
-
V
L
W
V
M
L
P
E
-
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
------
L
V
L
N
I
G
T
-
L
I
V
S
L
F
F
P
I
L
S
D
A
L
S
---------------------------------------------------------------------------------------------
5
PsiBlast_PDB
57.92
23%
-
- C2 -
-
4LDS
-
?
A:
[63-376]
---------------------------------------------------------------------------------------------
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
-----
F
I
I
G
A
---
L
--------
I
L
A
----------
A
S
T
N
---------
L
----------
A
L
L
-------
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
----
M
I
T
I
G
I
L
A
A
--
Y
L
V
N
Y
A
F
A
D
------
I
E
--------
G
W
R
W
M
L
-
G
L
A
V
V
P
S
V
I
L
L
V
-
G
-
I
----------------------
Y
F
M
P
E
S
P
R
W
L
L
----
E
N
R
----
N
E
E
A
A
R
----------------------------
Q
----
V
------------
M
------
K
I
T
Y
D
D
S
E
----
I
-
D
---
K
E
--
L
K
E
M
K
E
I
N
A
I
S
E
S
T
WTVIKSP
W
L
G
R
I
L
I
V
G
-------
C
-
I
F
A
I
F
--------
Q
Q
F
I
-
G
I
N
A
V
-
I
F
Y
S
S
S
I
F
A
K
A
--
G
L
G
E
----------
A
A
S
I
---
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
--
D
R
K
K
L
L
V
G
G
N
I
G
M
---
I
A
S
-
L
L
I
M
-
A
-
I
L
--
I
-
W
---
T
----
I
----
G
-
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
-
W
-
G
P
V
L
W
V
M
L
P
E
-
L
F
P
M
R
A
R
G
A
A
T
G
I
S
---------------------------------------------------------------------------------------------------------------------------
44
HHSearch
54.41
21%
-113
- C2 -
-
4J05
-
?
B:
[81-479]
---------------------------------------------------------------------------
A
A
--
A
--
N
I
G
C
V
V
G
Q
V
M
F
G
V
L
G
D
S
F
G
R
K
F
V
Y
G
K
E
L
I
L
I
I
V
A
T
I
F
Q
M
S
---
A
--------
P
S
H
----------
W
D
-
G
---------
N
R
V
-------
L
T
W
I
-------
T
I
C
R
V
F
L
G
I
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
I
H
R
R
G
T
L
L
C
F
I
F
A
N
Q
G
W
G
S
F
V
G
S
L
V
T
--
I
V
T
I
S
G
F
K
H
RLKSGH
T
H
D
V
D
K
----
A
W
R
I
L
I
-
G
L
S
L
I
P
A
F
G
T
L
Y
-
Q
-
R
---------------------------------------------------------------------------------------------------------
W
Q
E
F
V
A
----
Y
-
F
---
S
T
WN
H
F
----------------------
R
N
L
L
G
--------
S
-
M
L
G
W
F
--------
L
V
D
I
-
A
F
Y
G
I
-
N
L
N
Q
S
V
V
L
A
Q
I
--
G
F
A
G
KTGDVYDKLF
Q
L
A
T
---
G
N
I
I
V
T
A
L
G
F
L
P
G
Y
Y
F
T
L
F
L
I
D
I
V
--
G
R
K
K
L
Q
F
M
G
F
I
M
S
---
G
L
--
F
L
-
A
-
I
-
L
A
--
G
-
E
I--
D
H---
I
----
G
-
K
G
P
L
L
A
C
F
T
F
M
Q
F
F
F
N
---
F
G
A
-
N
-
T
-
T
T
F
I
V
A
A
E
-
L
F
P
T
R
I
R
A
S
A
H
G
I
S
A
------
A
A
G
K
C
G
A
-
I
L
S
S
L
V
F
N
Q
L
K
A
K
I
G
---------------------------------------------------------------------------------------------
22
Fugue
53.73
9%
-143
- C2 -
-
1PW4
-
GLPT_ECOLI
A:
[5-451]
-
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
E
Q
G
F
S
R
G
---------
D
L
G
F
A
L
S
G
--
I
--
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
--------
P
W
A
----------
T
S
S
I
---------
A
-----------
V
M
-------
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
--
L
L
G
M
A
W
F
N
-----------------
D
W
H
A
A
L
-
Y
M
P
A
F
C
A
I
L
V
A
L
-
F
-
A
----------------------
F
A
M
M
R
D
T
P
Q
------
S
C
G
----
L
P
P
I
E
E
----------------------------
Y
----
K
------------
N
------
D
T
A
K
Q
I
F
M
----
Q
-
Y
---
V
L
--
P
N
----------------------
K
L
L
W
Y
--------
I
-
A
I
A
N
V
--------
F
V
Y
L
-
L
R
Y
G
I
-
L
D
W
S
P
T
Y
L
K
E
V
-
K
H
F
A
L
----------
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
FR
G
N
R
G
A
T
G
V
F
F
M
T
L
---
V
T
--
I
A
T
I
-
V
-
Y
W
--
M
-
N
---
P
----
A
----
G
-
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
---
Y
G
P
-
V
-
M
-
L
I
G
L
H
A
L
E
-
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
------
L
F
G
Y
L
G
G
-
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
------------------------------------------------
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----
45
HHSearch
53.71
16%
-121
- C2 -
-
5C65
8
GTR3_HUMAN
A:
[68-428]
---------------------------------------------------------------------------
A
I
--
F
--
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
C
KV
A
--------
K
S
V
----------------------------------
E
M
L
-------
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
--
L
E
F
I
L
G
------------
S
E
E
----
L
W
P
L
L
L
-
G
F
T
I
L
P
A
I
L
Q
S
A
-
A
-
L
----------------------
P
F
C
P
E
S
P
R
F
------
L
L
I
----
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
----
S
------------
Q
------
E
K
Q
V
T
V
L
E
----
L
-
F
---
R
---
V
S
----------------------
S
Y
R
Q
P
--------
I
-
I
I
S
I
V
---------
L
Q
L
-
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--------------
P
I
---
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
--
G
R
R
T
L
H
M
I
G
L
G
G
M
---
A
F
--
C
S
T
--
L
-
M
T
--
V
-
S
L
L
L
K
D--------
M
-
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
---
I
G
P
-
G
-
P
-
I
P
W
F
I
V
A
E
-
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
------
C
S
N
W
T
S
N
-
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
---------------------------------------------------------------------------------------------
34
HHSearch
52.85
16%
-98
- C2 -
-
4ZW9
4
GTR3_HUMAN
A:
[90-450]
---------------------------------------------------------------------------
A
I
--
F
--
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
CKV
A
--------
K
S
V
----------------------------------
E
M
L
-------
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
--
L
E
F
I
L
------------
G
S
E
E
----
L
W
P
L
L
L
-
G
F
T
I
L
P
A
I
L
Q
S
A
-
A
-
L
----------------------
P
F
C
P
E
S
P
R
F
------
L
L
I
----
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
----
S
------------
Q
------
E
K
Q
V
T
V
L
E
----
L
-
F
---
R
---
V
S
----------------------
S
Y
R
Q
P
--------
I
-
I
I
S
I
V
--------
L
Q
L
S
-
Q
Q
L
S
G
-
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
----------
Q
E
P
I
---
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
--
G
R
R
T
L
H
M
I
G
L
G
G
M
---
A
F
--
C
S
T
--
L
-
M
T
--
V
-
S
L
L
L
K
DNY
N
G
----
M
-
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
---
I
G
P
-
G
-
P
-
I
P
W
F
I
V
A
E
-
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
------
C
S
N
W
T
S
N
-
F
L
V
G
L
L
F
P
S
A
A
H
Y
L
G
---------------------------------------------------------------------------------------------
42
HHSearch
51.08
14%
-117
- C2 -
-
5EQG
1
GTR1_HUMAN
A:
[70-430]
---------------------------------------------------------------------------
A
I
--
F
--
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
---
S
KLG-----
K
S
F
----------------------------------
E
M
L
-------
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
--
L
D
S
I
M
------------
G
N
K
D
----
L
W
P
L
L
L
-
S
I
I
F
I
P
A
L
L
Q
C
I
-
V
-
L
----------------------
P
F
C
P
E
S
P
R
F
------
L
L
I
NRNE
E
N
R
A
K
S
V
L
K
K
L
R
GTADV
T
H
D
L
Q
E
M
K
E
E
S
R
Q
----
M
----
M
------------
R
------
E
K
K
V
T
I
L
E
----
L
-
F
---
R
S
--
P
A
Y
R
--------------------
Q
P
I
L
I
--------
A
-
V
V
L
Q
L
--------
S
Q
Q
L
S
G
I
N
A
V
-
F
Y
Y
S
T
S
I
F
E
-
K
-
A
G
V
------------
Q
Q
P
V
---
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
--
G
R
R
T
L
H
L
I
G
L
A
G
M
---
A
G
--
C
A
I
L
-
M
-
T
I
--
A
L
A
L
--
L
E---
Q
LPW-
M
-
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
---
V
G
P
-
G
-
P
-
I
P
W
F
I
V
A
E
-
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
------
F
S
N
W
T
S
N
-
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
C
G
---------------------------------------------------------------------------------------------
27
Fugue
50.95
10%
-148
- C2 -
-
1PV6
-
LACY_ECOLI
A:
[1-417]
-------------------
M
Y
Y
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
H
I
S
K
--
S
D
T
G
I
I
F
A
A
I
S
L
F
S
--
L
--
L
F
-----
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
---
F
--------
I
F
G
----------
P
L
L
Q
---------
Y
N
I
-------
L
V
G
S
-------
I
V
G
G
I
Y
L
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
-----------
F
G
R
A
R
M
F
G
C
V
--
G
W
A
L
G
A
S
I
V
------
G
I
M
F
T
I
----
N
N
Q
F
V
F
-
W
L
G
S
G
C
A
L
I
L
A
V
-
L
-
L
----------------------
F
F
A
K
T
D
A
P
S
------
S
A
T
----
V
A
N
A
V
G
----------------------------
A
----
N
------------
H
------
S
A
F
S
L
K
L
A
----
L
-
E
---
L
F
--
R
Q
----------------------
P
K
L
W
F
--------
L
-
S
L
Y
V
I
--------
G
V
S
C
-
T
Y
D
V
F
-
D
Q
Q
F
A
N
F
F
T
S
F
-
F
A
T
G
E
----------
Q
G
T
R
---
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
--
N
R
I
G
G
K
N
A
L
L
L
A
G
---
T
I
--
M
S
V
R
-
I
-
I
G
--
S
-
S
---
F
----
A
----
T
-
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
---
P
F
L
-
L
-
V
-
G
C
F
K
Y
I
T
S
-
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
------
C
F
F
K
Q
L
A
-
M
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
---------------------------------------------------
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-
41
HHSearch
50.30
14%
-114
* C2 *
-
5EQH
1
GTR1_HUMAN
A:
[70-430]
---------------------------------------------------------------------------
A
I
--
F
--
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
---
S
KLG-----
K
S
F
----------------------------------
E
M
L
-------
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
--
L
D
S
I
M
------------
G
N
K
D
----
L
W
P
L
L
L
-
S
I
I
F
I
P
A
L
L
Q
C
I
-
V
-
L
----------------------
P
F
C
P
E
S
P
R
F
------
L
L
I
NRNE
E
N
R
A
K
S
V
L
K
K
L
RGTADV
T
H
D
L
Q
E
M
K
E
E
S
R
Q
----
M
----
M
------------
R
------
E
K
K
V
T
I
L
E
----
L
-
F
---
R
S
--
P
A
Y
R
--------------------
Q
P
I
L
I
--------
A
-
V
V
L
Q
L
--------
S
Q
Q
L
S
G
I
N
A
V
-
F
Y
Y
S
T
S
I
F
E
-
K
-
A
G
V
------------
Q
Q
P
V
---
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
--
G
R
R
T
L
H
L
I
G
L
A
G
M
---
A
G
--
C
A
I
L
-
M
-
T
I
--
A
L
A
L
--
L
E---
Q
LPW-
M
-
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
---
V
G
P
-
G
-
P
-
I
P
W
F
I
V
A
E
-
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
------
F
S
N
W
T
S
N
-
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
C
G
---------------------------------------------------------------------------------------------
47
HHSearch
47.29
15%
-
- C2 -
-
4YB9
-
GTR5_BOVIN
D:
[76-438]
---------------------------------------------------------------------------
S
M
--
F
--
P
F
G
G
F
L
G
S
L
M
V
G
P
L
V
N
N
L
G
R
K
G
T
L
L
F
N
N
I
F
S
I
V
P
A
L
L
M
G
F
---
S
ELA-----
K
S
F
----------------------------------
E
M
I
-------
I
V
A
R
V
L
V
G
I
C
A
G
L
S
S
N
V
V
P
M
Y
L
G
E
L
A
P
K
N
W
R
G
A
L
G
V
V
P
Q
L
F
I
T
I
G
I
L
V
A
Q
I
F
G
LR
S
L
L
A
--------------
N
E
E
----
G
W
P
I
L
L
-
G
L
T
G
I
P
A
V
L
Q
L
L
-
F
-
L
----------------------
P
F
F
P
E
S
P
R
Y
------
L
L
I
----
Q
K
K
D
E
A
AAKSALRRLAEIEEILE-----------
E
DRAE
K
------------
A
------
V
G
F
I
S
V
L
K
----
L
-
F
---
K
M
--
R
S
LR--------------------
W
Q
V
I
S
--------
I
-
I
V
L
M
A
--------
G
Q
Q
L
-
S
G
V
N
A
-
I
Y
Y
Y
A
D
Q
I
Y
L
S
-
A
G
V
N
E
----------
D
D
V
Q
---
Y
V
T
A
G
T
G
A
V
N
V
L
I
T
V
C
A
I
F
V
V
E
L
M
--
G
R
R
F
L
L
L
L
G
F
S
V
C
---
F
T
--
A
C
C
V
-
L
-
T
G
--
A
-
L
---
A
----
L
QDVI
S
W
M
P
Y
V
S
I
A
C
V
I
S
Y
V
I
G
H
---
A
L
G
P
S
-
P
-
I
P
A
L
L
V
T
E
-
I
F
L
Q
S
S
R
P
A
A
Y
M
V
A
G
------
T
V
H
W
L
S
N
-
F
T
V
G
L
V
F
P
F
I
Q
V
G
L
G
---------------------------------------------------------------------------------------------
53
HHSearch
47.27
14%
-108
- C2 -
-
3WDO
-
?
A:
[55-366]
---------------------------------------------------------------------------
G
I
--
Y
--
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
I
A
A
L
---
S
--------
D
S
I
----------
W
------------------------
G
I
-------
I
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
--
P
I
I
T
H
--------------
K
L
----
G
L
H
A
L
F
-
W
M
I
A
I
L
A
T
T
G
I
A
-
L
T
I
----------------------
W
V
V
P
N
S
S
T
H
------
V
L
N
----
R
E
-------------------------------------
S
------------
G
------
M
V
K
G
S
F
S
K
----
V
-
L
----
A
--
E
P
----------------------
R
L
L
K
L
--------
N
-
F
-
G
I
M
--------
C
L
H
M
-
L
L
M
S
T
-
F
V
A
L
P
G
Q
L
A
D
--
A
G
F
P
A
----------
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
--
K
Q
V
F
V
F
C
V
G
L
I
-----
V
---
V
A
E
I
-
V
-
L
---
W
-
N
---
A
----
Q
----
T
-
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
---
N
L
M
-
E
-
A
-
L
L
P
S
L
I
S
K
-
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
------
T
S
Q
F
L
G
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
---------------------------------------------------------------------------------------------
43
HHSearch
44.44
13%
-123
- C2 -
-
1PW4
-
GLPT_ECOLI
A:
[71-412]
----------------------------------------------------------------------------
G
--
I
--
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
--------
P
W
A
----------
T
S
-------------
S
-------
I
A
V
M
-------
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
--
L
L
G
M
A
-------------
W
F
N
----
D
W
H
A
A
L
-
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
-
F
----------------------
A
M
M
R
D
T
P
Q
S
------
C
G
L
PPI-
E
E
Y
K
N
D
---------------------------------------------------------
T
A
K
Q
I
F
M
Q
Y
-
V
---
L
P
--
N
K
----------------------
L
-
L
W
Y
--------
I
-
A
I
A
N
V
--------
F
V
Y
L
-
L
R
Y
G
I
-
L
D
W
S
P
T
Y
L
K
E
V
-
K
H
F
A
L
----------
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
--
F
R
G
N
R
G
A
T
G
V
F
F
M
---
T
L
V
T
I
A
T
I
-
V
-
Y
W
--
M
-
N
---
P
----
A
----
G
-
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
---
Y
G
P
-
V
-
M
-
L
I
G
L
H
A
L
E
-
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
------
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
---------------------------------------------------------------------------------------------