@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKI1: (2017-10-26 )
MKKPVPKIYRTTNWSSYNQALIKRGNISIWFDPKTQWYAQPQGKHGRNQTYSDTAIQCCLMIKSLFRLSLRMVTGFAQSLIKLCGLNWTAPDYSTVCRRKKHIDIAISYQQSRDGLHLLVDSTGLKFLGEGEWKRKKHQPEYRRQWRKLHIGIDAKTLQIRAVQLTTNNVSDSQVLGDLLDQIPLDERIDSVYTDGAYDTKHCRQVILDRDAHAVIPPRKNAKPWKDKKLRSLERNELLKTVKRLGRSLWKKWSGYHRRSLVETKMHCIK
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.....------....----10..---.---.....20----.------....------.---.---..30..---......40...---......------50........---60-------.---------------......------..70.....---------------------.-----------..------80....----------------------.-.--..90......-----------.----.---------.100-------....--..----.110.-------..-----------..--..120..--..---.-----.-.130--...-.-....140---..-.......150.-----------------..--.-----..--.160.......170.....-...180..-.-....190.......200------.......-.-210....--...---------------220-.-.......230.-------------....-----...240----........250..------------......260.......270---------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKKPV------PK
I
Y
----RTTN---W---S
S
Y
N
Q
A
-----
L
------
I
KRG------
N
---
I
---
S
I
W
FDP---KT
Q
W
Y
AQ-PQG---KHGRNQ------TY
S
D
T
A
I
Q
C
C
---
L
--------
M
---------------
I
K
S
L
F
R
------
L
S
L
R
M
V
T
G
F
---------------------
A
-----------
Q
S
------
L
I
K
L
CG----------------------L-N--WTA-P
D
Y
S
T
V
-----------C----R---------RK
K
H
-------
I
D
I
A
--
I
S
----
Y
QQSR-------D
G
-----------
L
H
--
L
L
VDSTG--
L
K
---
F
-----L-GEG---EWK-R-KKH
Q
P
-----
E
Y
-
R
R
Q
W
R
K
L
H
I
G
I
-----------------
D
A
--
K
-----
T
L
--
Q
I
R
A
V
Q
L
TTNNV
S
-
D
S
Q
V
L
-
G
D
L
L
D
QIP-
L
-
D
E
R
I
D
S
V
YTDGAY
D
T
K
-------
H
C
R
Q
V
I
L-D-RDAHAVI--PPR---------------KN--A-KPW
K
D
K
K
L
R
-
S
-------------
L
E
R
N
-----
E
L
L
K
T
-----
V
K
R
L
G
R
S
L
W
-
K
KW------------SGY
H
R
R
S
L
V
E
T
K
M
HCIK-----------------------------------------------------------------------
29
Fugue
60.37
18%
40
- C2 -
-
4IIK
3
SIDD_LEGPH
A:
[1-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
S
I
I
------
T
Q
I
C
NGVL
H
G
Q
S
---
Y
---
Q
S
G
S
N
D
-----
L
------
D
K
-
G
------
N
---
S
---
E
I
F
A
S
S
---
L
-
F
V
H
L
N
-
E
Q
G
---
K
E
I
K
D
S
D
D
K
I
V
I
G
Y
T
K
D
G
M
A
F
Q
---
I
--------
V
---------------
V
D
G
F
Y
G
------
C
E
R
Q
A
V
F
S
F
---------------------
I
-----------
D
N
YVLP--
L
I
D
N
F
S
----------------------
L
-
D
--
L
T
R
Y
P
D
S
K
K
V
-----------
T
----
E
S
L
I
H
T
I
Y
S
L
R
S
K
H
APLA
E
F
T
M
S
L
C
--
V
T
----
Y
Q
K
D
E
-------
Q
L
-----------
F
C
A
G
F
G
I
G
D
T
G
--
I
A
---
I
-----
K
R
N
E
G
---
T
------
I
E
Q
L
-----
V
C
-
H
T
E
V
D
G
F
K
D
A
F
-----------------
D
N
--
Y
-----
S
S
--
A
N
I
D
L
V
I
E
R
N
S
V
F
-
N
T
K
V
M
P
G
D
E
L
V
G
Y
T
Y
V
-
P
P
M
L
E
M
T
E
K
E
F
E
V
E
K
R
-------
I
V
R
H
L
N
L
-
D
-
P
G
N
F
D
D
K
--
D
P
L
---------------
F
S
Q
L
L
-
Q
V
V
K
S
K
Q
K
Q
-
L
-------------
V
E
Q
A
-----
K
E
T
G
Q
-----
I
Q
R
F
G
D
D
F
T
V
G
R
L
------------
V
I
P
D
Q
L
L
I
N
Q
L
R
I
H
A
L
S
-----------------------------------------------------------------------
27
Fugue
57.85
16%
13
- C2 -
-
1YT3
-
RND_ECOLI
A:
[1-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
N
Y
Q
M
I
TT
D
D
A
L
A
S
L
C
E
A
V
R
A
F
------
P
A
I
A
----
L
D
T
E
---
F
---
V
R
T
R
T
Y
-----
Y
------
P
Q
L
G
------
L
---
I
---
Q
L
-
F
D
G
---
E
H
L
A
L
I
D
-
P
L
G
ITD
W
S
P
L
K
A
------
I
L
R
D
P
S
I
T
K
F
---
L
H
AG
S
E
D
L
E
V
---------------
F
L
N
V
F
G
ELPQP
L
I
D
T
Q
I
L
A
A
F
---------------------
C
GRPMSWG
F
---
A
S
------
M
V
E
E
Y
S
G
V
T
L
D
KSESRTDWLARPLT
E
R
Q
C
-
E
--
Y
A
A
-
A
D
V
W
Y
L
-----------
L
----
P
---------
I
T
A
K
-------
L
M
V
E
--
T
E
A
S
GW
L
P
A
A
L
-------
D
E
-----------
C
R
--
L
M
Q
M
R
R
Q
--
E
V
---
V
-----
A
-
P
E
D
---
A
W
R
-
D
-
I
T
N
A
W
-----
Q
L
R
T
R
Q
L
A
C
L
Q
L
L
A
-----------------
D
W
--
R
-----
L
R
--
K
A
R
E
R
D
L
A
V
N
F
V
V
-
R
E
E
H
L
-
W
S
V
A
R
Y
M
P
-
G
S
L
G
E
L
D
S
L
G
L
S
G
S
E
I
R
F
-------
H
G
K
T
L
L
A
-
L
-
V
E
K
A
Q
T
L
--
P
E
D
ALPQPMLNLMDMPG
Y
R
K
--
A
-
F
K
A
I
K
S
L
I
T
-
D
-------------
V
S
E
T
H
KISA
E
L
L
A
S
-----
R
R
Q
I
N
Q
L
L
N
-
W
H
W
KLKPQNNLPELI
S
G
W
R
G
E
L
M
A
E
A
L
H
N
L
L
Q
EYPQ-------------------------------------------------------------------
23
Fugue
57.67
16%
18
- C1 -
-
4NWV
-
?
A:
[30-384]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVAPVAKANALRT
T
S
S
N
S
I
L
L
K
G
C
------
D
R
I
V
----
T
V
V
D
---
A
---
S
T
Y
D
A
G
--------------
S
A
------
I
---
V
---
S
I
P
I
T
P
---
D
I
A
Y
R
L
G
-
S
T
A
---
R
T
F
Q
R
I
------
K
Y
R
S
L
K
F
R
V
N
---
A
--------
Q
---------------
C
A
T
--
T
------
T
A
G
G
Y
V
A
G
F
---------------------
V
KDAADVLPTGT
A
S
------
I
P
Y
L
M
S
----------------------
N
-
T
G
S
F
T
Q
-
P
W
W
K
S
T
-----------
V
----
H
---------
N
V
K
I
-------
P
Q
K
L
--
F
Y
----
T
E
A
P
T
-------
R
G
ADA
V
R
E
Y
C
P
G
Q
F
H
--
V
L
V
D
S
K
P
--
S
Q
I
C
P
V
-----
T
-
V
D
L
---
E
W
V
-
V
-
E
L
H
D
A
-----
T
F
-
R
K
E
S
D
Q
T
A
I
S
A
-----------------
I
V
AD
H
-----
T
L
--
N
V
Y
G
L
P
A
T
S
N
R
V
G
-
H
I
L
I
S
-
P
I
G
Q
T
P
K
D
-
L
-
T
P
T
R
F
A
T
F
F
G
F
L
P
D
D
K
-------
F
C
--
V
R
I
-
P
-
T
P
V
D
V
V
L
--
T
G
D
---------------
N
V
--
Y
-
Q
S
V
E
A
T
H
I
R
-
A
Y
L
V
N
GGL
G
I
D
F
H
L
A
A
Y
N
-----
D
T
T
H
T
-----
I
Q
P
I
I
P
T
L
W
-
N
V
Y
D
V----------
T
G
A
V
T
A
P
F
T
S
A
I
Y
D
N
H
V
W
T
HK
D
K
F
V
P
V
S
FQDEPIP
G
T
V
F
D
Y
L
Y
PRS------------------------------------------
26
Fugue
52.15
21%
25
- C3 -
-
5GNG
-
Y1552_HAEIN
A:
[1-214]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
T
K
F
Y
D
YQGE
H
L
I
L
----
Y
F
A
G
---
W
---
G
T
P
P
D
A
VNH
L
I
L
------
P
E
N
H
------
D
---
L
---
L
I
C
Y
D
---------
Y
Q
-
D
L
N
---
L
D
F
D
L
S
------
A
Y
R
H
--
I
R
L
V
---
A
--------
W
---------------
S
M
G
V
W
-------
V
A
E
R
V
L
Q
G
I
----------------------------------
R
------
L
K
S
A
T
A
----------------------
V
-
N
--
G
T
G
-
L
P
C
D
D
---------------------------------------
S
F
G
--
I
P
----
Y
A
I
F
K
-------
G
T
-----------
L
E
--
N
L
T
E
N
T
R
--
L
K
---
F
-----
E
-
R
R
I
C
GD
K
A
S
-
F
-
E
R
Y
Q
L
-----
F
P
-
A
R
P
F
D
E
I
H
Q
E
L
-----------------
T
A
--
L
-----
F
A
--
M
I
Q
Q
---------------------------
D
K
R
I
D
L
I
----------------
H
W
A
N
A
W
V
S
S
-
R
D
K
--
I
F
--
T
P
A
---------------
N
Q
--
H
-
Q
Y
W
A
L
R
C
A
V
-
Q
-------------
E
I
E
G
-----
E
H
Y
-
V
-----
F
S
R
-----
F
-
T
H
W
------------
S
A
L
W
D
-----------------------------------------------------------------------------------
28
Fugue
48.43
16%
61
- C3 -
-
2PNN
1
TRPV1_RAT
A:
[11-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LY
D
R
R
S
I
------
F
D
A
V
----
A
Q
S
N
CQE
L
---
E
S
L
L
P
F
-----
L
------
Q
R
S
K
------
K
---
R
LTD
S
E
F
K
D
P
ETG
K
T
C
L
L
K
A
M
L
N
L
---
H
N
G
Q
N
--------------------
D
--------
T
---------------
I
A
L
L
L
D
------
V
A
R
K
--------------------------
T
-----------
D
S
------
L
K
Q
F
V
N
----------------------
A
-
S
--
Y
T
D
-
S
Y
Y
------------------------------
K
G
Q
-------
T
A
L
H
--
I
A
----
I
E
R
R
N
M
------
T
L
-----------
V
T
--
L
L
V
E
N
G
A
DV
Q
A
---
A
-----
A
-
N
G
D
---
F
F
K
-
K
-
T
K
G
R
P
-----
G
F
-
Y
--
F
G
E
L
P
L
S
L
-----------------
A
A
--
C
-----
T
N
--
Q
L
A
I
V
K
F
L
L
Q
N
----
S
W
Q
P
-
A
D
I
S
A
R
D
S
-
V
-
G
N
T
V
L
H
A
L
V
E
V
A
D
N
T
V
-------
D
N
T
K
F
V
T
-
S
M
Y
N
E
I
L
I
L
--
G
A
K
---------------
L
H
--
P
-
T
L
----
K
L
E
-
E
-------------
I
T
N
R
-----
K
G
L
T
P
-----
L
A
L
A
A
S
S
G
K
-
I
G
V
------------
L
A
Y
I
L
Q
R
E
I
H
------------------------------------------------------------------------------
22
Fugue
47.71
19%
-10
- C3 -
-
5T6O
-
PHAC_CUPNH
A:
[1-389]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAFEVGRNVAVTEGAVVFENEY
F
Q
L
L
Q
Y
K
P
LTDKVHA
R
P
L
L
M
V
P
P
C
------
I
N
K
Y
----
Y
I
L
D
---
L
QPE
S
S
L
V
R
H
-----
V
------
V
E
Q
G
------
H
T
V
F
L
---
V
S
W
R
N
P
---
D
A
S
M
A
G
S
-
T
--------
W
D
D
------
Y
I
E
H
A
A
I
R
A
I
---
E
--------
V
---------------
A
R
D
I
S
G
------
Q
D
K
I
N
V
L
G
F
A
V
G
G
T
I
V
S
T
A
L
A
V
L
A
A
R
GEHP
A
-----------
A
S
------
V
T
L
L
T
T
----------------------
L
L
D
--
F
A
D
-
T
G
I
L
D
V
FVDEGHVQGAP
C
----
A
---------
L
L
R
G
-------
L
E
L
A
N
T
F
S
----
F
L
R
P
N
-------
D
L
-----------
V
W
--
N
Y
V
V
D
N
Y
--
L
K
---
G
NTPVP
F
-
D
L
L
---
F
W
N
-
G
D
A
T
N
L
P
-----
G
P
-
W
Y
C
W
Y
L
R
H
T
Y
L
-----------------
Q
N
--
E
LKVPG
K
L
--
T
V
C
G
V
P
V
D
L
A
S
I
D
V
P
T
Y
I
Y
-
G
S
R
E
D
H
I
V
-----
P
W
T
A
A
Y
A
S
T
A
L
L
A
N
-------
K
L
R
F
V
L
G
-
A
-
S
G
H
I
A
G
V
I
N
P
P
A
---------------
K
N
--
K
R
S
H
W
T
N
D
A
L
P
-
E
-------------
S
P
Q
Q
-----
W
L
A
G
A
-----
I
E
H
H
G
-
S
W
W
-
P
D
W
------------
T
A
W
L
A
G
Q
A
G
A
K
R
A
A
P
A
N
YGNARYRAIEPAPGRYVKAKA--------------------------------------------------
1
PsiBlast_PDB
46.77
24%
-75
- C2 -
-
2HDW
-
Y2218_PSEAE
A:
[116-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
Q
T
-----
M
------
A
E
R
G
------
F
---
V
---
T
L
A
F
D
P
---
S
---
Y
T
G
-
E
S
G
---
G
Q
P
R
N
V
------
A
S
P
D
I
N
T
E
D
F
---
S
--------
A
---------------
A
V
D
F
I
S
------
L
-
L
P
E
V
N
R
E
---------------------
R
-----------
I
G
------
V
I
G
I
C
G
----------------------
W
-
G
--
G
M
A
-
L
N
A
V
A
V
-----------
D
----
K
---------
R
V
K
A
-------
V
V
T
S
--
T
M
----
Y
D
M
T
R
V
M
S
KGYN
D
S
-----------
V
T
--
L
E
Q
R
T
R
T
--
L
E
---
Q
-----
L
-
G
Q
Q
---
R
W
K
D
A
-
E
S
G
T
P
-----
A
Y
-
Q
P
P
Y
N
E
L
K
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
43.45
11%
25
- C2 -
-
3BXW
-
CHID1_HUMAN
A:
[33-393]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLLEKSQF
S
D
K
P
V
------
Q
D
R
G
----
L
V
V
T
---
D
---
L
K
A
E
S
V
-----
V
------
L
E
H
R
SYCSAK
A
---
R
---
D
R
H
F
A
G
---
D
V
L
G
Y
V
T
-
P
W
N
---
S
H
G
Y
D
V
------
T
K
V
F
G
S
K
F
T
Q
---
I
--------
S
P
VW
L
Q
L
K
R
RGRE
M
F
E
V
T
G
L
H
D
------
V
D
Q
G
W
M
R
A
V
---------------------
R
-----------
K
H
A
KG
L
H
I
V
P
R
L
L
F
----------------------
E
-
D
--
W
T
Y
-
D
D
F
R
N
V
-----------
L
D
S
E
D
E
---------
I
E
E
L
-------
S
K
T
V
--
V
Q
----
V
A
K
N
Q
HF-----
D
G
-----------
F
V
--
V
E
V
W
N
Q
L
--
L
S
---
Q
-----
R
-
V
G
L
---
I
H
M
-
L
-
T
H
L
A
E
-----
A
L
-
H
Q
A
R
L
L
A
L
L
V
I
P
P
AITPGTDQLGMFT
H
K
E
F
--
E
-----
Q
L
AP
V
L
D
G
F
S
L
M
T
Y
D
Y
S
-
T
A
H
Q
P
-
G
P
N
A
P
L
S
W
-
V
-
R
A
C
V
Q
V
L
D
P
K
S
K
W
R
S
K
IL
L
G
L
N
F
Y
G
M
D
Y
A
T
-
S
-
K
D
A
R
E
P
V
--
V
G
A
---------------
R
Y
--
I
-
Q
T
L
K
D
H
R
P
R
M
V
-------------
W
D
S
Q
-----
A
S
E
H
F
-----
F
E
Y
K
K
S
R
S
G
-
R
H
V
------------
V
F
Y
P
T
L
K
S
L
Q
V
R
L
E
L
A
R
E
L
G
V
G
V
S
I
WELGQGLDYFYDLL-------------------------------------------------
21
Fugue
43.37
19%
32
- C2 -
-
4X0Q
6
DPOLQ_HUMAN
A:
[6-772]
S
L
S
I
I
DVASDQ
N
L
F
Q
T
F
I
K
E
W
R
C
KK
R
F
S
I
S
L
A
C
E
K
I
RDDTLVV
G
L
A
V
C
WGGR
D
A
Y
Y
F
S
LL
D
P
S
L
T
LK
D
R
M
W
Y
L
Q
S
C
L
RKESD
K
E
C
S
V
V
I
YDF
I
Q
S
Y
K
I
L
L
LSCGISLE
Q
S
Y
E
D
P
K
V
A
C
W
L
L
DPDSQEPT
L
H
S
I
V
T
S
FLPHELPLLEGMETSQGIQSLGLNAGSEHSGR
Y
R
A
S
V
E
S
I
L
I
F
N
S
M
N
Q
L
N
S
L
L
Q
K
E
NLQDVFRKV
E
M
P
S
Q
Y
C
L
A
L
L
E
L
N
G
I
G
F
S
T
A
E
C
E
S
Q
K
H
I
M
Q
A
K
L
D
A
I
E
T
Q
A
Y
Q
LAGHSFSFTS
S
D
D
I
A
E
VLFLE
L
K
L
P
PQFSTS
K
D
V
L
N
K
L
K
A
L
H
------
P
L
P
G
----
L
I
L
E
---
W
---
R
R
I
T
N
A
-----
I
T
KV
V
F
P
L
Q
R
E
------
K
---
C
---
L
N
P
F
L
G
---
M
E
R
I
Y
P
V
-
S
Q
S
---
H
T
A
T
G
R
I
-----
T
F
T
E
P
N
I
Q
N
V
P
R
D
F
--------
E
---------------
I
K
M
G
M
P
------
F
S
I
S
M
-------------------------
R
-----------
H
A
------
F
V
P
F
P
G
----------------------
G
-
S
--
I
L
A
-
A
D
Y
S
-------------------------------
Q
-------
L
E
L
R
--
I
L
----
A
H
L
S
H
-------
D
R
-----------
R
L
--
I
Q
V
L
N
T
G
--
A
D
---
V
-----
F
-
R
S
I
---
A
A
E
-
W
-
K
M
I
E
P
ESVG
D
D
L
-
R
Q
Q
A
K
Q
I
C
Y
G
I
I
Y
GM-------------
G
A
--
K
-----
S
L
--
G
E
Q
M
------
G
I
K
-
E
N
D
A
A
-
C
Y
I
D
S
F
K
S
-
R
-
Y
T
G
I
N
Q
F
M
T
E
T
V
K
N
C
K
-------
R
D
G
F
V
Q
T
-
I
-
L
G
R
R
R
Y
L
--
P
G
I
---------------
K
D
--
N
-
N
P
Y
R
K
A
H
A
E
-
R
-------------
Q
A
I
N
-----
T
I
V
Q
G
S
A
A
D
I
V
K
I
A
T
V
N
I
Q
-
K
Q
L
------------
E
T
F
H
S
----
T
F
K
S
H
G
H
R
E
G
M
L
Q
S
DC
P
I
R
G
G
F
F
I
LQLHD
E
L
L
Y
E
V
A
EED
V
V
Q
V
A
Q
I
V
K
N
E
M
E
S
AVKLS
V
K
L
K
V
K
V
K
I
G
A
S
W
G
E
L
K
D
F
D
V
30
Fugue
40.91
14%
32
- C2 -
-
3WRY
1
?
A:
[8-431]
-------------------------------------------------------------------------------------------------------------------------------------------------------S
P
R
V
F
C
I
G
TADTK
F
D
E
L
R
F
L
S
E
H
V
R
S
S
L
N
S
F
S
N
KS
S
F
K
V
G
V
T
V
V
D
VSTSWKETNSCADFDFVP
S
K
D
V
L
S
C
HTLGEETMGTFAD
T
R
G
L
A
I
A
I
M
S
K
A
L
E
T
F
L
S
I
A
N
D
E
Q
NLA
G
V
I
G
L
G
G
S
G
G
T
S
L
L
S
S
A
F
R
S
L
P
I
G
I
------
P
K
V
I
----
I
S
T
V
---
A
---
S
G
Q
T
E
S
-----
Y
------
I
G
T
S
------
D
---
L
---
V
L
F
P
S
V
---
V
D
I
C
G
I
N
-
N
V
S
---
K
V
V
L
S
N
------
A
G
A
A
F
A
G
M
V
I
---
G
--------
R
---------------
L
E
S
K
F
T
------
V
G
V
T
M
F
-
G
V
---------------------
T
-----------
T
P
------
C
V
N
A
V
K
----------------------
E
-
R
--
L
V
K
-
E
G
Y
E
T
L
-----------
V
----
F
---------
H
A
T
G
-------
V
G
G
R
--
A
M
----
E
D
L
V
R
-------
G
G
-----------
F
--------------------------------------------------------
I
Q
G
V
L
-----------------
D
I
--
T
-----
T
T
--
E
V
A
D
Y
V
V
G
G
V
M
A
C
-
D
S
S
R
F
-
D
A
I
L
E
K
-------
K
I
P
L
V
L
S
V
G
A
L
D
--------------
M
V
-
N
-
F
G
P
K
T
T
I
--
P
P
E
---------------
F
Q
--
Q
-
R
K
I
H
E
H
N
------------------
E
Q
V
-----
S
L
M
R
T
-----
T
V
G
E
N
K
K
F
A
-
A
F
I
------------
A
E
K
L
N
K
A
S
S
S
V
C
V
C
L
P
E
KGVSALDAPGKDFYD
P
E
A
T
S
C
L
T
R
E
L
Q
M
L
L
E
NNER
C
Q
V
K
V
L
PYHIND
A
E
F
A
N
A
L
V
D
S
F
L
E
I
S
PK-------
2
PsiBlast_PDB
39.00
38%
-84
- C2 -
-
1I3Q
-
RPB1_YEAST
A:
[915-987]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
G
S
E
I
L
-
G
D
L
K
L
Q
V
L
-
L
-
D
E
E
----
Y
K
Q
L
V
K
D
R
K
-------
F
L
R
E
V
F
V
-
D
-
G
E
A
N
W
P
L
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
38.49
38%
-102
- C2 -
-
1K83
-
RPB1_YEAST
A:
[915-988]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
G
S
E
I
L
-
G
D
L
K
L
Q
V
L
-
L
-
D
E
E
----
Y
K
Q
L
V
K
D
R
K
-------
F
L
R
E
V
F
V
-
D
-
G
E
A
N
W
P
L
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
37.31
38%
-85
- C2 -
-
1I50
-
RPB1_YEAST
A:
[915-987]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
G
S
E
I
L
-
G
D
L
K
L
Q
V
L
-
L
-
D
E
E
----
Y
K
Q
L
V
K
D
R
K
-------
F
L
R
E
V
F
V
-
D
-
G
E
A
N
W
P
L
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
37.04
38%
-89
- C2 -
-
1Y1W
-
RPB1_YEAST
A:
[915-987]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
G
S
E
I
L
-
G
D
L
K
L
Q
V
L
-
L
-
D
E
E
----
Y
K
Q
L
V
K
D
R
K
-------
F
L
R
E
V
F
V
-
D
-
G
E
A
N
W
P
L
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
36.73
38%
-73
- C2 -
-
1TWF
-
RPB1_YEAST
A:
[915-987]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
G
S
E
I
L
-
G
D
L
K
L
Q
V
L
-
L
-
D
E
E
----
Y
K
Q
L
V
K
D
R
K
-------
F
L
R
E
V
F
V
-
D
-
G
E
A
N
W
P
L
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
36.23
38%
-90
- C2 -
-
1WCM
-
RPB1_YEAST
A:
[915-987]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
G
S
E
I
L
-
G
D
L
K
L
Q
V
L
-
L
-
D
E
E
----
Y
K
Q
L
V
K
D
R
K
-------
F
L
R
E
V
F
V
-
D
-
G
E
A
N
W
P
L
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
36.04
38%
-44
- C2 -
-
1TWA
-
RPB1_YEAST
A:
[915-1005]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
G
S
E
I
L
-
G
D
L
K
L
Q
V
L
-
L
-
D
E
E
----
Y
K
Q
L
V
K
D
R
K
-------
F
L
R
E
V
F
V
-
D
-
G
E
A
N
W
P
L
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
35.80
38%
-90
- C2 -
-
1Y77
-
RPB1_YEAST
A:
[915-987]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
G
S
E
I
L
-
G
D
L
K
L
Q
V
L
-
L
-
D
E
E
----
Y
K
Q
L
V
K
D
R
K
-------
F
L
R
E
V
F
V
-
D
-
G
E
A
N
W
P
L
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
35.79
38%
-33
- C2 -
-
1TWC
-
RPB1_YEAST
A:
[915-1008]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
G
S
E
I
L
-
G
D
L
K
L
Q
V
L
-
L
-
D
E
E
----
Y
K
Q
L
V
K
D
R
K
-------
F
L
R
E
V
F
V
-
D
-
G
E
A
N
W
P
L
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
35.05
33%
-86
- C2 -
-
2EZI
-
TNPA_BPMU
A:
[217-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
-
P
S
R
A
T
A
-----------
F
----
R
---------
R
I
Q
Q
-------
L
D
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------