@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKJ5: (2017-10-26 )
MVSAYNELPRTPANFVALSPLRYLERAAYIYPDQASIIHGNRQISWKQTYQRCRQFASQLQQLGIVKNDTVSVLLPNVPAMIEAHFAVPMAGAVLNTLNTRLDAKTIAFMLEHAETKVLLVDPEFVNLAREALSLIPNQHIIVIDVADEEYEGENQFLGSFEYEEWLAQGDANFEWQLPEDEWDAISLNYTSGTTGNPKGVVYHHRGAYLNAASNILACGMKPRAVYLWTLPLFHCNGWCFAWSIAASGGTNICLRKVDPELVMQLIAKHKVDYFCGAPIVLSMIINLPKEKQPSIEHHVEVMVAGAAPPVAVIEGMRNIGINVNHVYGLTETYGPSALCASQAGWSDLSITEQAQLHSRQGVPYPLQDSMRVLDPETMQPVPNDGETMGEIMFRGNIVMKGYLKNPKATEEAFAGGWFHTGDLAVCHPDGYAKITDRSKDIIISGGENISSLEVEDVLYKHPAVLTAAVVAKPDERWQEVPCAFIELKTEASVTPEEIIEHCQKELARFKVPKDVVITEIPKTSTGKLQKFILREWAKERA
Atome Classification :
(20 SA)
.........10........20..-----......30...--...-..--40..--..-.....50........60.........70........80........90........100.......110.......120.......130..--.....-.140.--.......150..-.....160.......170.......180.---......190.......200.......210-.---...-....220...------....230------........--.240.-.......250..-.---.-.--..260.......270.......280......----.290.......----300....--...310.......-320..---.......330.......340.......350.......360.......370.......380......-----.390.......400.......410...-.-...420.......430.......440.......450.......460.......470......-.480.......490--..---......500....-...510.-..-.-.-..-520........530.......540
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVS
A
Y
N
ELPRTPAN
F
V
AL
S
P
L
R
Y
-----
L
E
R
A
AYIYPDQ--
A
S
I
-
I
H--G-NR--QI-
S
W
K
Q
T
Y
Q
R
C
R
Q
F
A
S
Q
L
-
Q
QLGIVKN
D
T
V
S
V
LLPNV
P
A
M
I
E
A
H
FAV
P
M
A
G
A
V
L
N
T
L
N
TRL
D
A
K
T
I
A
F
M
L
EHAE
T
K
V
L
L
VD
P
E
F
V
N
L
A
R
E
-
A
L
--
S
LIPN-Q
H
-
I
I
--
V
I
DVADEEYEGE-N
Q
F
L
G
S
F
E
Y
E
E
W
L
AQGDA
N
F
E
WQLPEDEW---
D
A
I
S
L
N
YTSGTTGNPK
G
V
V
Y
HHRGA
Y
L
N
--
A
---
A
S
N
-
I
L
ACGMKP
R
A
------
V
Y
L
W
T
--------
L
P
L
FHCN
G
--
W
C
-
F
A
-
W
S
I
AASGG
T
N
I
C
-
L
---R-K--V
D
P
E
L
V
M
Q
L
I
A
KHKVDYFCG
A
P
I
V
L
S
M
I
INL----PKEKQP
S
I
E
H
H
----
V
E
V
M
VAG--AA
P
P
V
A
V
I
E
G
M
R
N-I--G
I
---
N
V
N
H
V
Y
GLTETYG
P
S
A
L
C
ASQAGWSDLS
I
T
E
Q
A
Q
LHSRQGVPYPLQDSMRVLDPETMQPVPNDG
E
T
-----
M
G
E
I
M
FRG
N
I
V
M
K
G
YLKNPK
A
T
E
E
A
FA-G-GWFHTG
D
L
A
V
CHPDGYAKITDRSK
D
I
I
I
SGGENISS
L
E
V
E
D
V
L
YKHPA
V
L
T
A
A
V
VAKP
D
E
R
W
-
Q
EV
P
C
A
F
I
E
L
KTE---AS---V
T
P
E
E
I
I
E
H
C
Q
K
E
-
L
A
R
FKVP-K
D
-
V
-
V
-
I
T
-E-IPKTS
T
G
K
L
Q
K
F
I
L
R
E
W
A
K
ERA
1
PsiBlast_PDB
84.46
37%
-6
- C4 -
-
1ULT
1
LCFCS_THET8
A:
[23-535]
----------------------
F
-----
L
E
R
A
A
A
L
F
G
R
K
E
V
V
S
R
-
L
H
--
T
-
G
E
V
H
R
T
-
T
Y
A
E
V
Y
Q
R
A
R
R
L
M
G
G
L
-
R
A
L
G
V
G
V
G
D
R
V
A
T
L
G
F
N
H
F
R
H
L
E
A
Y
F
A
V
P
G
M
G
A
V
L
H
T
A
N
P
R
L
S
P
K
E
I
A
Y
I
L
N
H
A
E
D
K
V
L
L
F
D
P
N
L
L
P
L
V
-
E
-
A
I
R
G
E
L
K
T
V
-
Q
H
-
F
V
--
V
M
D
E
K
A
P
E
---------
G
Y
L
A
Y
E
E
--
A
L
G
E
E
A
D
P
V
R
V
P
E
R
A
-----
A
C
G
M
A
Y
T
T
G
T
T
G
L
P
K
G
V
V
Y
S
H
R
A
L
V
L
H
S
L
A
---
A
S
L
-
V
D
G
T
A
L
S
E
K
D
------
V
V
L
P
V
--------
V
P
M
F
H
V
N
A
--
W
C
-
L
P
-
Y
A
A
T
L
V
G
A
K
Q
V
L
-
P
---
G
P
R
--
L
D
P
A
S
L
V
E
L
F
D
G
E
G
V
T
F
T
A
G
V
P
T
V
W
L
A
L
A
D
Y
----
L
E
S
T
G
H
R
L
K
T
L
----
R
R
L
V
V
G
G
--
S
A
A
P
R
S
L
I
A
R
F
E
R
-
M
--
G
V
---
E
V
R
Q
G
Y
G
L
T
E
T
S
P
V
V
V
Q
N
F
V
K
S
H
L
E
S
L
S
E
E
E
K
L
T
L
K
A
K
T
G
L
P
I
P
L
V
-
R
L
R
V
A
D
E
E
G
-
R
P
V
P
K
D
G
K
A
-----
L
G
E
V
Q
L
K
G
P
W
I
T
G
G
Y
Y
G
N
E
E
A
T
R
S
A
L
T
P
D
-
G
F
F
R
T
G
D
I
A
V
W
D
E
E
G
Y
V
E
I
K
D
R
L
K
D
L
I
K
S
G
G
E
W
I
S
S
V
D
L
E
N
A
L
M
G
H
P
K
V
K
E
A
A
V
V
A
I
P
H
P
K
W
-
Q
E
R
P
L
A
V
V
V
P
R
G
E
---
K
P
----
T
P
E
E
L
N
E
H
L
L
K
A
G
F
A
K
W
Q
L
P
-
D
A
-
Y
-
V
-
F
A
E
E
-
I
P
R
T
S
A
G
K
F
L
K
R
A
L
R
E
Q
Y
K
---
52
HHSearch
81.48
26%
-65
- C4 -
-
4WV3
1
?
B:
[10-518]
-----------------
Y
N
A
V
D
I
-----
L
E
R
N
L
P
V
R
A
N
K
--
T
A
L
-
F
T
--
P
-
D
R
--
E
M
-
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
-
K
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
E
F
L
P
L
I
E
S
-
I
R
--
G
N
L
P
M
-
L
E
--
H
--
I
V
V
I
G
E
G
P
Q
-------
E
G
Y
L
S
F
N
D
W
I
R
P
Q
P
T
T
-
L
E
A
A
Q
S
H
R
E
---
D
I
C
S
L
N
Y
S
S
G
T
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
T
--
A
---
Q
L
W
G
V
N
V
L
G
L
R
E
S
D
------
R
T
F
A
L
--------
A
K
L
F
F
T
F
G
--
T
G
G
N
L
-
I
F
P
W
Y
V
G
A
S
C
V
L
-
F
---
P
-
G
AA
R
V
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
----
K
D
F
S
Q
H
D
L
S
S
L
----
R
L
C
V
S
A
S
--
E
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
--
G
V
---
D
I
I
D
G
I
G
C
T
E
N
F
H
I
F
I
S
N
R
P
G
D
-----------
I
R
P
G
S
S
G
K
P
V
E
G
-
Y
E
L
K
L
V
D
D
E
-
G
K
T
V
P
A
--
G
E
-----
I
G
N
V
L
L
R
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
Q
-
G
-
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
----
L
I
K
P
K
A
F
I
I
L
K
P
----
Q
I
PS
E
A
L
I
R
Q
I
T
D
H
C
T
E
K
-
M
A
A
Y
K
R
P
-
R
W
-
I
-
E
F
V
T
-
E
-
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
L
--
21
PsiBlast_CBE
81.36
37%
-14
- C4 -
-
1V25
1
LCFCS_THET8
B:
[23-535]
----------------------
F
-----
L
E
R
A
A
A
L
F
G
R
K
EV
V
S
R
-
L
H
--
T
-
G
E
VH
R
T
-
T
Y
A
E
V
Y
Q
R
A
R
R
L
M
G
G
L
-
R
A
L
G
V
G
V
G
D
R
V
A
T
L
G
F
N
H
F
R
H
L
E
A
Y
F
A
V
P
G
M
G
A
V
L
H
T
A
N
P
R
L
S
P
K
E
I
A
Y
I
L
N
H
A
E
D
K
V
L
L
F
D
P
N
L
L
P
L
V
-
E
-
A
I
RG
E
L
K
T
V
-
Q
H
-
F
V
--
V
M
D
E
K
A
P
E
---------
G
Y
L
A
Y
E
E
--
A
L
G
E
E
A
D
P
V
R
V
P
E
R
A
-----
A
C
G
M
A
Y
T
T
G
T
T
G
L
P
K
G
V
V
Y
S
H
R
A
L
V
L
H
SL
A
---
A
S
L
-
V
D
G
T
A
L
S
E
K
D
------
V
V
L
P
V
--------
V
P
M
F
H
V
N
A
--
W
C
-
L
P
-
Y
A
A
T
L
V
G
A
K
Q
V
L
-
P
---
G
P
R
--
L
D
P
A
S
L
V
E
L
F
D
G
E
G
V
T
F
T
A
G
V
P
T
V
W
L
A
L
A
D
Y
----
L
E
S
T
G
H
R
L
K
T
L
----
R
R
L
V
V
G
G
--
S
A
A
P
R
S
L
I
A
R
F
E
R
-
M
--
G
V
---
E
V
R
Q
G
Y
G
L
T
E
T
S
P
V
V
V
Q
N
F
V
K
S
H
L
E
S
L
S
E
E
E
K
L
T
L
K
A
K
T
G
L
P
I
P
L
V
-
R
L
R
V
A
D
E
E
G
-
R
P
V
P
K
D
G
K
A
-----
L
G
E
V
Q
L
K
G
P
W
I
T
G
G
Y
Y
G
N
E
E
A
T
R
S
A
L
T
P
D
-
G
F
F
R
T
G
D
I
A
V
W
D
E
E
G
Y
V
E
I
K
D
R
L
K
D
L
I
K
S
G
G
E
W
I
S
S
V
D
L
E
N
A
L
M
G
H
-----
A
A
V
V
A
I
P
H
P
K
W
-
Q
E
R
P
L
A
V
--------------------
N
E
H
L
L
K
A
G
F
A
K
W
Q
L
P
-
D
A
-
Y
-
V
-
F
----------
G
K
F
L
K
R
A
L
R
E
Q
Y
K
---
51
HHSearch
81.11
26%
-63
- C4 -
-
4WV3
1
?
A:
[10-518]
-----------------
Y
N
A
V
D
I
-----
L
E
R
N
L
P
V
R
A
N
K
--
T
A
L
-
F
T
--
P
-
D
R
--
E
M
-
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
-
K
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
E
F
L
P
L
I
E
S
-
I
R
--
G
N
L
P
M
-
L
E
--
H
--
I
V
V
I
G
------------
G
Y
L
S
F
N
D
W
I
R
P
Q
P
T
T
-
L
E
A
A
Q
S
H
R
E
---
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
T
--
A
---
Q
L
W
G
V
N
V
L
G
L
R
E
S
D
------
R
T
F
A
L
--------
A
K
L
F
F
T
F
G
--
T
G
G
N
L
-
I
F
P
W
Y
V
G
A
S
C
V
L
-
F
---
P
-
G
AA
R
V
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
----
K
D
F
S
Q
H
D
L
S
S
L
----
R
L
C
V
S
A
S
--
E
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
--
G
V
---
D
I
I
D
G
I
G
C
T
E
N
F
H
I
F
I
S
N
R
P
G
D
-----------
I
R
P
G
S
S
G
K
P
V
E
G
-
Y
E
L
K
L
V
D
D
E
-
G
K
T
V
P
A
--
G
E
-----
I
G
N
V
L
L
R
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
Q
-
G
-
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
-
L
I
K
P
K
A
F
I
I
L
K
P
E
---
Q
I
P
S
E
A
L
I
R
Q
I
T
D
H
C
T
E
K
-
M
A
A
Y
K
R
P
-
R
W
-
I
-
E
F
V
T
-
E
-
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
L
--
7
PsiBlast_PDB
79.26
29%
-46
- C4 -
-
5X8G
4
?
A:
[7-481]
----------------------
W
-----
L
M
Q
R
A
Q
L
T
P
E
R
--
I
A
L
-
I
Y
--
E
-
D
Q
--
T
V
-
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
-
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
S
F
E
K
K
E
Y
E
------------
H
-
I
V
Q-
T
I
D
V
-
D
E
L
M
K
E
A
-
A
E
E
I
E
I
E
A
Y
----
M
Q
M
D
A
T
---------------
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
Y
F
S
--
A
---
V
S
S
-
A
L
N
L
G
I
T
E
Q
D
------
R
W
L
I
A
--------
L
P
L
F
H
I
S
G
--
L
S
-
A
L
-
F
K
S
V
I
Y
G
M
T
V
V
L
-
H
---
Q
-
R
--
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
---
V
Q
T
M
L
A
S
L
----
L
E
E
T
N
R
C
P
E
S
I
----
R
C
I
L
L
G
G
--
G
P
A
P
L
P
L
L
E
E
C
R
E
-
K
--
G
F
---
P
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
P
E
F
S
M
E
K
L
G
---------
S
A
G
K
P
L
F
S
C
E
I
K
I
E
R
D
G
Q
V
C
E
P
Y
E
H
----------
G
E
I
M
V
K
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
Q
-
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
K
W
-
G
K
V
P
H
A
Y
L
V
L
--
H
---
K
P
---
V
S
A
G
E
L
T
D
Y
C
K
E
R
-
L
A
K
Y
K
R
P
-
K
K
F
F
-
V
-
L
D
-
R
-
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
A
R
K
---
6
PsiBlast_PDB
78.76
29%
-46
- C4 -
-
5X8F
4
?
A:
[7-481]
----------------------
W
-----
L
M
Q
R
A
Q
L
T
P
E
R
--
I
A
L
-
I
Y
--
E
-
D
Q
--
T
V
-
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
-
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
S
F
E
K
K
E
Y
E
------------
H
-
I
V
Q
-
T
I
D
V
-
D
E
L
M
K
E
A
-
A
E
E
I
E
I
E
A
Y
----
M
Q
M
D
A
T
---------------
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
Y
F
S
--
A
---
V
S
S
-
A
L
N
L
G
I
T
E
Q
D
------
R
W
L
I
A
--------
L
P
L
F
H
I
S
G
--
L
S
-
A
L
-
F
K
S
V
I
Y
G
M
T
V
V
L
-
H
---
Q
-
R
--
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
---
V
Q
T
M
L
A
S
L
----
L
E
E
T
N
R
C
P
E
S
I
----
R
C
I
L
L
G
G
--
G
P
A
P
L
P
L
L
E
E
C
R
E
-
K
--
G
F
---
P
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
P
E
F
S
M
E
K
L
G
---------
S
A
G
K
P
L
F
S
C
E
I
K
I
E
R
D
G
Q
V
C
E
P
Y
E
H
----------
G
E
I
M
V
K
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
Q
-
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
K
W
-
G
K
V
P
H
A
Y
L
V
L
--
H
---
K
P
---
V
S
A
G
E
L
T
D
Y
C
K
E
R
-
L
A
K
Y
K
R
P
-
K
K
F
F
-
V
-
L
D
-
R
-
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
A
R
K
---
2
PsiBlast_PDB
78.62
29%
-63
- C4 -
-
3R44
1
FAC13_MYCTU
A:
[34-509]
--------------------------------
A
Y
V
E
P
S
T
------------
D
V
--
R
M
-
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
-
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
G
A
----------------
P
S
-
A
P
-
V
I
--
D
A
I
R
A
Q
A
D
P
P
G
T
V
T
D
W
I
G
A
D
S
L
A
E
R
L
R
S
A
A
A
D
-
E
P
A
V
E
C
G
G
D
---
D
N
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
T
H
E
S
V
H
S
A
--
A
---
S
S
W
-
A
S
T
I
D
V
R
Y
R
D
------
R
L
L
L
P
--------
L
P
M
F
H
V
A
A
--
L
T
-
T
V
-
I
F
S
A
M
R
G
V
T
L
I
S
-
M
---
P
-
Q
--
F
D
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
R
Q
V
----
P
E
F
A
E
L
D
A
P
D
F
----
R
Y
F
I
T
G
G
--
A
P
M
P
E
A
L
I
K
I
Y
A
A
-
K
--
N
I
---
E
V
V
Q
G
Y
A
L
T
E
S
C
G
G
G
T
L
L
L
S
E
D
A
L
R
K
A
G
S
A
G
R
A
T
M
F
T
D
V
A
V
R
G
--
D
D
G
V
----------
I
R
E
H
G
E
-------
G
E
V
V
I
K
S
D
I
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
D
-
N
-
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
-
G
E
I
A
A
A
I
V
-
V
A
D
Q
---
N
E
---
V
S
E
Q
Q
I
V
E
Y
C
G
T
R
-
L
A
R
Y
K
L
P
-
K
K
-
V
-
I
-
F
A
-
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
------
5
PsiBlast_PDB
77.51
29%
-52
- C4 -
-
5GTD
4
MENE_BACSU
A:
[10-484]
----------------------
W
-----
L
M
Q
R
A
Q
L
T
P
E
R
--
I
A
L
-
I
Y
--
E
-
D
Q
--
T
V
-
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
-
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
S
F
E
K
K
E
Y
E
------------
H
-
I
V
Q-
T
I
D
V
-
D
E
L
M
K
E
A
-
A
E
E
I
E
I
E
A
Y
----
M
Q
M
D
A
T
---------------
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
Y
F
S
--
A
---
V
S
S
-
A
L
N
L
G
I
T
E
Q
D
------
R
W
L
I
A
--------
L
P
L
F
H
I
S
G
--
L
S
-
A
L
-
F
K
S
V
I
Y
G
M
T
V
V
L
-
H
---
Q
-
R
--
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
---
V
Q
T
M
L
A
S
L
----
L
E
E
T
N
R
C
P
E
S
I
----
R
C
I
L
L
G
G
--
G
P
A
P
L
P
L
L
E
E
C
R
E
-
K
--
G
F
---
P
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
P
E
F
S
M
E
K
L
G
---------
S
A
G
K
P
L
F
S
C
E
I
K
I
E
R
D
G
Q
V
C
E
P
Y
E
H
----------
G
E
I
M
V
K
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
Q
-
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
K
W
-
G
K
V
P
H
A
Y
L
V
L
--
H
---
K
P
---
V
S
A
G
E
L
T
D
Y
C
K
E
R
-
L
A
K
Y
K
I
P
A
K
F
-
F
-
V
-
L
D
-
R
-
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
A
R
K
---
59
HHSearch
77.35
30%
-27
- C4 -
-
3R44
1
FAC13_MYCTU
A:
[15-513]
----------------
M
K
N
I
G
W
M
-----
L
R
Q
R
A
T
V
S
P
R
L
--
Q
A
Y
-
V
E
PS
T
-
D
V
--
R
M
-
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
-
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
G
A
P
S
A
P
V
I
D
A
-
I
R
--
A
Q
A
D
P
-
P
--
G
T
--
V
T
D
W
I
------------
G
A
D
S
L
A
E
R
L
R
S
A
A
A
-
D
E
P
A
V
E
C
G
G
D
---
D
N
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
T
H
E
S
V
H
S
A
--
A
---
S
S
W
-
A
S
T
I
D
V
R
Y
R
D
------
R
L
L
L
P
--------
L
P
M
F
H
V
A
A
--
L
T
-
T
V
-
I
F
S
A
M
R
G
V
T
L
I
S
-
M
---
P
-
Q
--
F
D
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
R
Q
V
----
P
E
F
A
E
L
D
A
P
D
F
----
R
Y
F
I
T
G
G
--
A
P
M
P
E
A
L
I
K
I
Y
A
A
-
K
--
N
I
---
E
V
V
Q
G
Y
A
L
T
E
S
C
G
G
G
T
L
L
L
S
E
D
A
L
---------
R
K
A
G
S
A
G
R
A
T
M
F
-
T
D
V
A
V
R
G
D
D
-
G
V
I
R
E
--
H
-
G
-----
E
G
E
V
V
I
K
S
D
I
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
D
-
N
-
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
-
G
E
I
A
A
A
I
V
V
A
D
Q
N
----
E
---
V
S
E
Q
Q
I
V
E
Y
C
G
T
R
-
L
A
R
Y
K
L
P
-
K
K
-
V
-
I
F
A
E
-
A
-
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
A
--
4
PsiBlast_PDB
76.41
29%
-52
- C4 -
-
5BUS
1
MENE_BACSU
A:
[10-484]
----------------------
W
-----
L
M
Q
R
A
Q
L
T
P
E
R
--
I
A
L
-
I
Y
--
E
-
D
Q
--
T
V
-
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
-
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
S
F
E
K
K
E
Y
E
------------
H
-
I
V
Q-
T
I
D
V
-
D
E
L
M
K
E
A
-
A
E
E
I
E
I
E
A
Y
----
M
Q
M
D
A
T
---------------
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
Y
F
S
--
A
---
V
S
S
-
A
L
N
L
G
I
T
E
Q
D
------
R
W
L
I
A
--------
L
P
L
F
H
I
S
G
--
L
S
-
A
L
-
F
K
S
V
I
Y
G
M
T
V
V
L
-
H
---
Q
-
R
--
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
---
V
Q
T
M
L
A
S
L
----
L
E
E
T
N
R
C
P
E
S
I
----
R
C
I
L
L
G
G
--
G
P
A
P
L
P
L
L
E
E
C
R
E
-
K
--
G
F
---
P
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
P
E
F
S
M
E
K
L
G
---------
S
A
G
K
P
L
F
S
C
E
I
K
I
E
R
D
G
Q
V
C
E
P
Y
E
H
----------
G
E
I
M
V
K
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
Q
-
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
K
---
K
V
P
H
A
Y
L
V
L
--
H
---
K
P
---
V
S
A
G
E
L
T
D
Y
C
K
E
R
-
L
A
K
Y
K
I
P
A
K
F
-
F
-
V
-
L
D
-
R
-
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
A
R
K
---
56
HHSearch
75.82
26%
-111
* C4 *
-
3IVR
5
?
A:
[6-397]
-----------------
F
T
L
A
D
V
-----
Y
R
R
N
A
A
L
F
P
D
R
--
T
A
F
-
M
V
--
D
-
G
V
--
R
L
-
T
H
R
D
Y
L
A
R
A
E
R
L
A
S
G
L
-
L
R
D
G
V
H
T
G
D
R
V
A
I
L
S
Q
N
C
S
E
M
I
E
L
I
G
A
V
A
L
I
G
A
I
L
L
P
V
N
Y
R
L
N
A
D
E
I
A
F
V
L
G
D
G
A
P
S
V
V
V
A
G
T
D
Y
R
D
I
V
A
G
-
V
L
--
P
S
L
G
G
-
V
--
K
K
--
A
Y
A
I
G
D
G
S
--------
G
P
F
A
P
F
K
D
L
A
S
D
T
---
P
F
S
A
P
E
F
G
A
A
---
D
G
F
V
I
I
H
T
A
A
--
G
R
P
R
G
A
L
I
S
Q
G
N
L
L
I
A
--
Q
---
S
S
L
-
V
D
A
W
R
L
T
E
A
D
------
V
N
L
G
M
--------
L
P
L
F
H
V
T
G
--
L
G
-
L
M
-
L
T
L
Q
Q
A
G
G
A
S
V
I
-
A
---
A
-
K
--
F
D
P
A
Q
A
A
R
D
I
E
A
H
K
V
T
V
M
A
E
F
A
P
M
L
G
N
I
L
D
Q
----
A
A
P
--
A
Q
L
A
S
L
----
R
A
V
-
T
G
L
----
D
T
P
E
T
I
E
R
F
E
A
-
T
C
P
N
A
---
T
F
W
A
T
F
G
Q
S
E
T
S
G
L
S
T
F
A
P
Y
R
D
------------
R
P
K
S
A
G
R
P
L
F
W
-
R
T
V
A
V
V
D
A
E
-
D
R
P
L
P
P
--
G
E
-----
V
G
E
I
V
L
R
G
P
T
V
F
K
G
Y
W
N
N
A
A
A
T
Q
H
A
F
R
-
N
-
G
W
H
H
T
G
D
M
G
R
F
D
A
D
G
Y
L
F
Y
A
G
R
A
---------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.70
29%
-50
- C4 -
-
5BUR
3
MENE_BACSU
A:
[10-481]
----------------------
W
-----
L
M
Q
R
A
Q
L
T
P
E
R
--
I
A
L
-
I
Y
--
E
-
D
Q
--
T
V
-
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
-
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
S
F
E
K
K
E
Y
E
------------
H
-
I
V
Q-
T
I
D
V
-
D
E
L
M
K
E
A
-
A
E
E
I
E
I
E
A
Y
----
M
Q
M
D
A
T
---------------
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
Y
F
S
--
A
---
V
S
S
-
A
L
N
L
G
I
T
E
Q
D
------
R
W
L
I
A
--------
L
P
L
F
H
I
S
G
--
L
S
-
A
L
-
F
K
S
V
I
Y
G
M
T
V
V
L
-
H
---
Q
-
R
--
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
---
V
Q
T
M
L
A
S
L
----
L
E
E
T
N
R
C
P
E
S
I
----
R
C
I
L
L
G
G
--
G
P
A
P
L
P
L
L
E
E
C
R
E
-
K
--
G
F
---
P
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
P
E
F
S
M
E
K
L
G
---------
S
A
G
K
P
L
F
S
C
E
I
K
I
E
R
D
G
Q
V
C
E
P
Y
E
H
----------
G
E
I
M
V
K
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
Q
-
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
---
G
K
V
P
H
A
Y
L
V
L
--
H
---
K
P
---
V
S
A
G
E
L
T
D
Y
C
K
E
R
-
L
A
K
Y
K
I
P
A
K
F
-
F
-
V
-
L
D
-
R
-
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
------
57
HHSearch
75.59
26%
-113
- C4 -
-
3IVR
4
?
B:
[6-396]
-----------------
F
T
L
A
D
V
-----
Y
R
R
N
A
A
L
F
P
D
R
--
T
A
F
-
M
V
--
D
-
G
V
--
R
L
-
T
H
R
D
Y
L
A
R
A
E
R
L
A
S
G
L
-
L
R
D
G
V
H
T
G
D
R
V
A
I
L
S
Q
N
C
S
E
M
I
E
L
I
G
A
V
A
L
I
G
A
I
L
L
P
V
N
Y
R
L
N
A
D
E
I
A
F
V
L
G
D
G
A
P
S
V
V
V
A
G
T
D
Y
R
D
I
V
A
G
-
V
L
--
P
S
L
G
G
-
V
--
K
K
--
A
Y
A
I
G
D
G
S
--------
G
P
F
A
P
F
K
D
L
A
S
D
T
---
P
F
S
A
P
E
F
G
A
A
---
D
G
F
V
I
I
H
T
A
A
--
G
R
P
R
G
A
L
I
S
Q
G
N
L
L
I
A
--
Q
---
S
S
L
-
V
D
A
W
R
L
T
E
A
D
------
V
N
L
G
M
--------
L
P
L
F
H
V
T
G
--
L
G
-
L
M
-
L
T
L
Q
Q
A
G
G
A
S
V
I
-
A
---
A
-
K
--
F
D
P
A
Q
A
A
R
D
I
E
A
H
K
V
T
V
M
A
E
F
A
P
M
L
G
N
I
L
D
Q
----
A
A
P
--
A
Q
L
A
S
L
----
R
A
V
-
T
G
L
----
D
T
P
E
T
I
E
R
F
E
A
-
T
CP
N
A
---
T
F
W
A
T
F
G
Q
S
E
T
S
G
L
S
T
F
A
P
Y
R
D
------------
R
P
K
S
A
G
R
P
L
F
W
-
R
T
V
A
V
V
D
A
E
-
D
R
P
L
P
P
--
G
E
-----
V
G
E
I
V
L
R
G
P
T
V
F
K
G
Y
W
N
N
A
A
A
T
Q
H
A
F
R
-
N
-
G
W
H
H
T
G
D
M
G
R
F
D
A
D
G
Y
L
F
Y
A
G
R
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.05
26%
-5
- C4 -
-
4WV3
1
?
A:
[7-517]
-------------------
P
L
Y
Y
NAVDI
L
E
R
N
L
P
V
R
A
N
K
--
T
A
L
-
F
T
--
P
-
D
R
--
E
M
-
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
-
K
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
E
F
L
P
L
I
E
S
-
I
R
--
G
N
L
P
M
L
E
H
-
I
V
--
V
I
--------
G
------
G
Y
L
S
F
N
D
W
I
R
P
Q
P
T
T
L
E
A
A
Q
S
H
R
E
----
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
T
--
A
Q
L
W
G
V
N
-
V
L
G
L
R
E
S
D
R
T
------
F
A
L
A
K
--------
L
F
F
T
F
G
T
G
G
N
L
I
-
F
P
-
W
Y
V
G
A
S
C
V
L
F
P
G
-
A
---
A
-
R
--
V
A
S
N
-
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
----
K
D
F
S
Q
H
D
L
S
S
L
----
R
L
C
V
S
A
S
--
E
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
--
G
V
---
D
I
I
D
G
I
G
C
T
E
N
F
-------------------
H
I
F
I
S
N
R
P
G
D
I
R
P
-
G
S
S
G
K
P
V
E
G
Y
E
L
K
L
V
D
D
E
G
K
T
VPAG
E
I
G
N
V
L
L
R
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
Q
-
G
-
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
-
L
I
K
P
K
A
F
I
I
L
K
P
E
Q
I
P
S
E
---
A
L
I
R
Q
I
T
D
H
C
T
E
K
-
M
A
A
Y
K
R
P
-
R
W
-
I
E
F
-
V
T
-
E
-
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
---
43
HHSearch
74.49
23%
-44
- C4 -
-
5UPS
8
?
B:
[6-512]
----------------
H
T
T
I
G
D
V
-----
L
R
E
H
R
R
S
H
P
G
R
--
T
A
L
-
V
D
--
G
-
P
V
--
R
L
-
T
W
P
E
L
D
D
R
V
N
R
L
A
G
S
L
-
A
A
S
G
I
G
R
G
D
R
I
M
W
L
G
Q
N
S
F
R
V
Y
E
L
I
A
A
A
G
K
L
G
A
M
V
C
V
G
Y
W
R
W
A
P
P
E
M
E
F
A
L
R
D
F
D
P
H
L
V
V
W
Q
H
Q
E
I
H
E
T
V
A
R
T
R
--
E
A
L
G
S
-
D
D
T
A
R
--
W
L
R
H
D
S
A
P
--------
Q
D
P
D
G
Y
E
A
F
L
A
A
G
G
-
L
A
D
P
D
L
D
I
D
P
D
---
S
P
V
L
V
L
Y
T
A
A
M
S
G
R
Q
C
G
S
L
L
S
H
T
N
L
I
A
M
--
A
---
T
A
A
-
A
W
L
G
D
I
D
H
T
T
------
A
F
L
N
S
--------
G
P
M
F
H
I
G
N
--
H
Q
-
F
W
G
M
P
T
L
L
M
A
G
K
N
V
I
-
V
---
R
-
R
--
V
V
A
E
E
V
R
D
L
L
V
A
E
E
C
T
H
A
F
L
M
P
P
T
V
A
E
I
V
R
L
----
N
R
D
T
G
H
D
L
S
R
L
----
R
A
T
V
A
P
H
LW
E
G
M
A
T
T
D
T
S
R
F
T
R
-
S
--
G
A
---
A
A
G
R
G
Y
G
Q
T
E
L
S
G
F
A
V
T
A
A
Y
G
G
-----------
P
A
A
G
N
A
G
R
P
G
P
G
-
L
T
V
R
V
L
D
T
A
-
G
R
E
C
A
V
G
--
E
-----
A
G
E
I
C
A
R
G
T
V
V
H
R
G
Y
W
N
R
D
E
V
N
A
H
R
F
R
-
S
-
G
W
W
H
T
T
D
L
G
R
R
E
P
D
G
S
L
T
F
L
G
T
T
T
R
M
L
K
S
A
A
E
N
I
F
P
A
E
V
E
N
C
I
E
Q
H
P
A
V
R
E
A
A
V
I
G
V
P
N
T
R
W
-
A
Q
D
V
K
A
V
V
V
L
E
P
D
---
A
G
---
V
S
E
Q
E
I
I
D
H
C
R
P
R
-
I
A
S
Y
K
K
P
-
K
S
-
V
-
A
F
A
A
-
A
-
L
P
R
T
V
S
G
A
R
D
Y
D
A
L
D
K
E
Y
G
G
--
13
PsiBlast_PDB
73.94
28%
-6
- C4 -
-
5BSW
1
4CL2_TOBAC
A:
[38-532]
-----------------------------------
F
S
S
R
--
P
C
L
-
I
N
--
G
A
N
K
--
Q
I
Y
T
Y
A
D
V
E
L
N
S
R
K
V
A
A
G
L
-
H
K
Q
G
I
Q
P
K
D
T
I
M
I
L
L
P
N
S
P
E
F
V
F
A
F
I
G
A
S
Y
L
G
A
I
S
T
M
A
N
P
L
F
T
P
A
E
V
V
K
Q
A
K
A
S
S
A
K
I
I
V
T
Q
A
C
H
V
N
K
V
K
D
--
Y
--
A
F
E
N
D
-
V
K
-
I
I
--
C
I
D
S
A
P
E
----------
G
C
L
H
F
S
-
V
L
T
Q
A
N
---
E
H
D
I
P
E
V
E
I
Q
PD
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
L
V
T
S
--
V
---
A
Q
Q
-
V
--
D
G
E
N
P
N
L
Y
I
H
SE
D
V
M
L
C
V
--------
L
P
L
F
H
I
Y
S
--
L
N
-
S
V
-
L
L
C
G
L
R
V
G
A
A
I
L
I
M
---
Q
-
K
--
F
D
I
V
S
F
L
E
L
I
Q
R
Y
K
V
T
I
---
G
P
F
V
P
P
I
V
L
A
I
------
A
K
S
P
M
V
D
D
Y
DLSS
V
R
T
V
M
S
G
--
A
A
P
L
G
K
E
L
E
D
T
V
R
-
A
--
K
F
P
N
A
K
L
G
Q
G
Y
G
M
T
E
A
-
G
P
L
A
M
C
L
A
F
A
-------
K
E
P
F
E
I
K
S
G
A
C
G
T
V
V
R
N
A
E
M
K
I
V
D
P
K
T
G
N
S
L
P
R
N
Q
S
-------
G
E
I
C
I
R
G
D
Q
I
M
K
G
Y
L
N
D
P
E
A
T
A
R
T
I
D
-
K
E
G
W
L
Y
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
L
N
H
P
N
I
S
D
A
A
V
V
P
M
K
D
E
Q
A
-
G
E
V
P
V
A
F
V
V
R
S
N
G
---
S
T
---
I
T
E
D
E
V
K
D
F
I
S
K
Q
-
V
I
F
Y
K
R
I
-
K
R
-
V
-
F
-
F
V
-
D
A
I
P
K
S
P
S
G
K
I
L
R
K
D
L
R
-------
10
PsiBlast_PDB
73.23
29%
12
- C4 -
-
5IE0
2
4CLLA_ARATH
A:
[10-512]
----------------------------
L
E
N
V
A
K
K
F
P
D
R
--
R
A
L
S
V
S
--
G
-
K
F
--
N
L
-
T
H
A
R
L
H
D
L
I
E
R
A
A
S
R
L
V
S
D
A
G
I
K
P
G
D
V
V
A
L
T
F
P
N
T
V
E
F
V
I
M
F
L
A
V
I
R
A
R
A
T
A
A
P
L
N
A
A
Y
T
A
E
E
F
E
F
Y
L
S
D
S
D
S
K
L
L
L
T
S
K
E
G
N
A
P
A
Q
E
-
A
A
--
S
K
L
K
I
-
S
H
-
V
T
A
T
L
L
D
A
------
G
S
-
D
L
V
L
S
-------
V
A
D
-------
E
L
V
N
H
P
D
---
D
G
A
L
F
L
H
T
S
G
T
T
S
R
P
K
G
V
P
L
----
T
Q
L
N
--
L
---
A
S
S
-
V
K
N
I
----
K
A
------
V
Y
K
L
T
ES
D
S
T
V
I
V
L
P
L
F
H
V
H
G
--
L
L
-
A
G
-
L
L
S
S
L
G
A
G
A
A
V
T
-
L
P
AA
G
-
R
--
F
S
A
T
T
F
W
P
D
M
K
K
Y
N
A
T
W
Y
T
A
V
P
T
I
H
Q
I
I
L
D
R
H
A
S
H
P
E
T
E
Y
P
K
L
R
F
-----
I
R
S
C
S
A
S
--
L
A
P
-
V
I
L
S
R
L
E
E
A
-
F
--
G
A
---
P
V
L
E
A
Y
A
M
T
E
A
---
T
H
L
M
S
S
N
P
------
L
P
E
E
G
P
-
H
K
P
G
S
V
G
K
P
V
G
Q
E
M
A
I
L
N
E
K
G
E
I
Q
E
P
N
N
--------
K
G
E
V
C
I
R
G
P
N
V
T
K
G
Y
K
N
N
P
E
A
N
K
A
G
F
E
-
F
-
G
W
F
H
T
G
D
I
G
Y
F
D
T
D
G
Y
L
H
L
V
G
R
I
K
E
L
I
N
R
G
G
E
K
I
S
P
I
E
V
D
A
V
L
L
T
H
P
D
V
S
Q
G
V
A
F
G
V
P
D
E
K
Y
G
E
E
I
N
C
A
V
I
P
-
R
E
G
---
T
T
---
V
T
E
E
D
I
K
A
F
C
K
K
N
-
L
A
A
F
K
V
P
-
K
R
-
V
-
F
-
I
T
-
D
N
L
P
K
T
A
S
G
K
I
Q
R
R
I
V
A
Q
H
F
L
E
--
44
HHSearch
72.90
23%
-48
- C4 -
-
5UPT
5
?
A:
[6-512]
----------------
H
T
T
I
G
D
V
-----
L
R
E
H
R
R
S
H
P
G
R
--
T
A
L
-
V
D
--
G
-
P
V
--
R
L
-
T
W
P
E
L
D
D
R
V
N
R
L
A
G
S
L
-
A
A
S
G
I
G
R
G
D
R
I
M
W
L
G
Q
N
S
F
R
V
Y
E
L
I
A
A
A
G
K
L
G
A
M
V
C
V
G
Y
W
R
W
A
P
P
E
M
E
F
A
L
R
D
F
D
P
H
L
V
V
W
Q
H
Q
E
I
H
E
T
V
A
R
T
R
--
E
A
L
G
S
-
D
D
T
A
R
--
W
L
R
H
D
S
A
P
--------
Q
D
P
D
G
Y
E
A
F
L
A
A
G
G
-
L
A
D
P
D
L
D
I
D
P
D
---
S
P
V
L
V
L
Y
T
A
A
M
S
G
R
Q
C
G
S
L
L
S
H
T
N
L
I
A
M
--
A
---
T
A
A
-
A
W
L
G
D
I
D
H
T
T
------
A
F
L
N
S
--------
G
P
M
F
H
I
G
N
--
H
Q
-
F
W
G
M
P
T
L
L
M
A
G
K
N
V
I
-
V
---
R
-
R
--
V
V
A
E
E
V
R
D
L
L
V
A
E
E
C
T
H
A
F
L
M
P
P
T
V
A
E
I
V
R
L
----
N
R
D
T
G
H
D
L
S
R
L
----
R
A
T
V
A
P
H
LW
E
G
M
A
T
T
D
T
S
R
F
T
R
-
S
--
G
A
---
A
A
G
R
G
Y
G
Q
T
E
L
S
G
F
A
V
T
A
A
Y
G
G
-----------
P
A
A
G
N
A
G
R
P
G
P
G
-
L
T
V
R
V
L
D
T
A
-
G
R
E
C
A
V
G
--
E
-----
A
G
E
I
C
A
R
G
T
V
V
H
R
G
Y
W
N
R
D
E
V
N
A
H
R
F
R
-
S
-
G
W
W
H
T
T
D
L
G
R
R
E
P
D
G
S
L
T
F
L
G
T
T
T
R
M
L
K
S
A
A
E
N
I
F
P
A
E
V
E
N
C
I
E
Q
H
P
A
V
R
E
A
A
V
I
G
V
P
N
T
R
W
-
A
Q
D
V
K
A
V
V
V
L
E
P
D
---
A
G
---
V
S
E
Q
E
I
I
D
H
C
R
P
R
-
I
A
S
Y
K
K
P
-
K
S
-
V
-
A
F
A
A
-
A
-
L
P
R
T
V
S
G
A
R
D
Y
D
A
L
D
K
E
Y
G
G
--
11
PsiBlast_PDB
72.82
29%
13
- C4 -
-
5IE2
2
4CLLA_ARATH
A:
[10-511]
----------------------------
L
E
N
V
A
K
K
F
P
D
R
--
R
A
L
S
V
S
--
G
-
K
F
--
N
L
-
T
H
A
R
L
H
D
L
I
E
R
A
A
S
R
L
V
S
D
A
G
I
K
P
G
D
V
V
A
L
T
F
P
N
T
V
E
F
V
I
M
F
L
A
V
I
R
A
R
A
T
A
A
P
L
N
A
A
Y
T
A
E
E
F
E
F
Y
L
S
D
S
D
S
K
L
L
L
T
S
K
E
G
N
A
P
A
Q
E
-
A
A
--
S
K
L
K
I
-
S
H
-
V
T
A
T
L
L
D
A
------
G
S
-
D
L
V
L
S
-------
V
A
D
---
D
S
A
T
E
L
V
N
H
P
D
---
D
G
A
L
F
L
H
T
S
G
T
T
S
R
P
K
G
V
P
L
----
T
Q
L
N
--
L
---
A
S
S
-
V
K
N
I
----
K
A
------
V
Y
K
L
T
ES
D
S
T
V
I
V
L
P
L
F
H
V
H
G
--
L
L
-
A
G
-
L
L
S
S
L
G
A
G
A
A
V
T
-
L
P
AA
G
-
R
--
F
S
A
T
T
F
W
P
D
M
K
K
Y
N
A
T
W
Y
T
A
V
P
T
I
H
Q
I
I
L
D
R
H
A
S
H
P
E
T
E
Y
P
K
L
R
F
-----
I
R
S
C
S
A
S
--
L
A
P
-
V
I
L
S
R
L
E
E
A
-
F
--
G
A
---
P
V
L
E
A
Y
A
M
T
E
A
---
T
H
L
M
S
S
N
P
------
L
P
E
E
G
P
-
H
K
P
G
S
V
G
K
P
V
G
Q
E
M
A
I
L
N
E
K
G
E
I
Q
E
P
N
N
--------
K
G
E
V
C
I
R
G
P
N
V
T
K
G
Y
K
N
N
P
E
A
N
K
A
G
F
E
-
F
-
G
W
F
H
T
G
D
I
G
Y
F
D
T
D
G
Y
L
H
L
V
G
R
I
K
E
L
I
N
R
G
G
E
K
I
S
P
I
E
V
D
A
V
L
L
T
H
P
D
V
S
Q
G
V
A
F
G
V
P
D
E
K
Y
G
E
E
I
N
C
A
V
I
P
-
R
E
G
---
T
T
---
V
T
E
E
D
I
K
A
F
C
K
K
N
-
L
A
A
F
K
V
P
-
K
R
-
V
-
F
-
I
T
-
D
N
L
P
K
T
A
S
G
K
I
Q
R
R
I
V
A
Q
H
F
L
---
17
PsiBlast_PDB
72.45
27%
0
- C4 -
-
5BST
1
4CL2_TOBAC
A:
[38-533]
-----------------------------------
F
S
S
R
--
P
C
L
-
I
N
--
G
A
N
K
--
Q
I
Y
T
Y
A
D
V
E
L
N
S
R
K
V
A
A
G
L
-
H
K
Q
G
I
Q
P
K
D
T
I
M
I
L
L
P
N
S
P
E
F
V
F
A
F
I
G
A
S
Y
L
G
A
I
S
T
M
A
N
P
L
F
T
P
A
E
V
V
K
Q
A
K
A
S
S
A
K
I
I
V
T
Q
A
C
H
V
N
K
V
K
D
--
Y
--
A
F
E
N
D
-
V
K
-
I
I
--
C
I
D
S
A
P
E
----------
G
C
L
H
F
S
-
V
L
T
Q
A
N
---
E
H
D
I
P
E
V
E
I
Q
PD
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
L
V
T
S
--
V
---
A
Q
Q
-
V
--
D
G
E
N
P
N
L
Y
I
H
SE
D
V
M
L
C
V
--------
L
P
L
F
H
I
Y
S
--
L
N
-
S
V
-
L
L
C
G
L
R
V
G
A
A
I
L
I
M
---
Q
-
K
--
F
D
I
V
S
F
L
E
L
I
Q
R
Y
K
V
T
I
---
G
P
F
V
P
P
I
V
L
A
I
------
A
K
S
P
M
V
D
D
Y
DLSS
V
R
T
V
M
S
G
--
A
A
P
L
G
K
E
L
E
D
T
V
R
-
A
--
K
F
PNA
K
L
G
Q
G
Y
G
M
T
E
A
G
P
V
L
A
M
C
L
A
F
A
-------
K
E
P
F
E
I
K
S
G
A
C
G
T
V
V
R
N
A
E
M
K
I
V
D
P
K
T
G
N
S
L
P
R
N
Q
S
-------
G
E
I
C
I
R
G
D
Q
I
M
K
G
Y
L
N
D
P
E
A
T
A
R
T
I
D
-
K
E
G
W
L
Y
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
L
N
H
P
N
I
S
D
A
A
V
V
P
M
K
D
E
Q
A
-
G
E
V
P
V
A
F
V
V
R
S
N
G
---
S
T
---
I
T
E
D
E
V
K
D
F
I
S
K
Q
-
V
I
F
Y
K
R
I
-
K
R
-
V
-
F
-
F
V
-
D
A
I
P
K
S
P
S
G
K
I
L
R
K
D
L
R
-------