@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKL4: (2017-10-27 )
MREKMRFPTLVFDIETLTDLKAGAHLYHLDLPEADVEQALTKIRRQESGMDFQRLPLHEIVCISGLWIDESGFRLFSFSREHYSEAEILQKFLSIFDKRHPTLVSWNGSQFDLPVILFRAMYHGLSAPGLFDQGELDSQKRFNNYQNRYHHRHIDLMDVMAMFNGRNFQKLDDVACILGLPGKRGESGYHVPEYVRTEQWLKLTSYCEGDVLNTWFIYLRWLLLKGQMNVDEHNHWISSSIEYLQTMPQQADFLEVWQRTSKHTEFTSHYFNPLNF
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------......-...10--.....-----------...20..---------......30-..--------......40........50...--.--.--...60--------......-------..70-.-------------.--.-..----------------------.----------------------.--.80..-------......90-.........100...-.-..-------------.---------.110.----------------......120..--...---...130....-------------..-.----.-----140---------..---.---.-------.----...---150-..-----...--....160-----.----.---.....170.-----------......180..---.----.---.---..190----..-....--.200---.......---.210...-...-----.220------.-------..-----......230.......240.....-----..250----------..---....-..--------------.260....------.-------------..270....--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MREKMR-F
P
T
L
V
--
F
D
I
E
T
-----------
L
T
DLKAG---------
A
H
L
Y
H
LDL-
P
E
--------
A
D
V
E
Q
A
L
T
K
I
R
R
Q
ESGMDFQR--L--P--
L
H
E
I
V
--------
C
I
S
G
L
W
-------IDES-G-------------
F
--
R
-
L
F
----------------------
S
----------------------
F
--
S
R
E
HY-------
S
E
A
E
I
L
Q
--
K
F
L
S
I
F
DKRH
P
-
T
L
V
-
S
-WN-------------G---------SQF
D
L
----------------
P
V
I
L
F
R
A
-
M
YH--GLS---APGLF-DQGE-------------L
D
-
S
----
Q
-----
K
-
R
---------
F
N
---
N
---
Y
-------
Q
----
N
R
Y
---
H
---HR-----H
I
D
--
L
M
D
V
M
A
M
-----F----N---GR
N
F
Q
K
L
D
D
-----------
V
A
C
I
LGLPGKR---G----E---S---GYHV
P
----
E
Y
-
V
R
T
E
--
Q
W
L
----
K
L
T
SYCE---G
D
V
L
N
T
W
-
F
I
Y
-----
L
R
--------
W
-------
L
L
-----LKGQMN
V
D
E
H
N
H
W
I
S
S
S
I
E
Y
L
Q
TM-----PQQ------------A
D
---
F
L
E
V
-
W
Q
--------------
R
TSKHT
E
F
------
T
-------------
S
H
YFNPLNF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
87.06
23%
0
- C- -
-
2GV9
1
DPOL_HHV1K
B:
[317-653]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
-
Y
K
L
M
C
--
F
D
I
E
C
-----------
K
A
G
G
E
D
--------------------------------------------
E
L
A
F
P
V
--
A
GH
P
--
E
D
L
V
I
--------
Q
I
S
C
L
L
-------
Y
D
L
S
-
T
TALE
H
--------
V
--
L
-
L
F
----------------------
S
L
G
S
C
D
L
P
E
S
H
L
N
E
L
A
A
R
GLPT
P
V
--
V
L
E
F
D
-------
S
E
F
E
M
L
L
--
A
F
M
T
L
V
K
Q
Y
G
P
E
F
V
T
-
G
-
Y
N
-------------
I
---------
I
N
F
D
W
----------------
P
F
L
L
A
K
L
T
D
I
Y
--
K
V
P
---
L
D
G
-
Y
-
G
R
M
N
-------------
G
R
G
V
----
F
-----
R
-
V
---------
W
D
I
--
G
QSH
F
-------
Q
KRS
K
I
K
V
---
N
G--
M
V
-----
N
I
D
--
M
Y
G
I
I
T
D
K
----
I
----
K
---
L
S
S
-
Y
K
L
N
A
-----------
V
A
E
A
V
L
K
D
K
K
K
---
D
----
L
---
S
---
Y
R
D
I
P
----
A
Y
-
Y
A
T
G
P
A
Q
R
G
----
V
I
G
E
Y
C
I
---
Q
D
S
L
L
V
G
-
Q
L
F
-----
F
K
--------
F
-------
L
P
-----
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
67.53
21%
-44
- C6 -
-
5MDN
-
?
B:
[161-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
-
L
R
V
L
A
--
F
D
I
E
V
-----------
Y
N
E
R
------------------------------------------------
G
S
P
D
--
P
--
L
--
R
D
P
V
V
--------
M
L
A
V
K
T
-------
S
D
G
R
---------------
E
--
E
-
V
----------------------------------------------
F
--
E
A
E
G
R
-------
D
D
R
R
V
I
R
--
G
F
V
D
F
V
K
E
F
D
P
D
V
I
V
-
G
-
Y
N
-------------
S
---------
N
G
F
D
W
----------------
P
Y
L
S
E
R
A
-
K
A
L
--
G
V
P
---
L
R
V
D
R
-
L
-
G
G
-------------
V
P
-
Q
----
Q
-----
S
-
V
---------
Y
G
---
H
---
W
------------
S
V
V
---
G
---
R
A
-----
N
V
D
--
L
Y
N
I
V
D
E
-----
F
P---
E
---
I
K
V
-
K
T
L
D
R
-----------
V
A
E
Y
F
G
V
M
K
R
S
ERV
L
----
I
---
P
---
G
H
K
V
Y
----
E
Y
-
W
N
D
P
A-
K
R
P
----
T
L
M
R
Y
V
L
---
D
D
V
R
S
T
L
-
G
L
A
-----
E
K
--------
L
-------
L
P
-----
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
63.04
18%
-9
- C6 -
-
4M8O
3
DPOE_YEAST
A:
[31-1186]
A
L
S
A
Q
Q
L
L
N
A
S
K
I
D
D
I
D
S
M
M
GF
E
R
Y
V
P
P
QYNGRFDAKDIDQ
I
P
G
R
V
G
WLT
N
M
H
A
T
L
V
S
QEVTTN
Q
G
I
S
G
V
D
F
Y
F
L
D
EEG
G
S
F
K
S
T
V
V
Y
D
P
Y
F
F
I
A
C
NDESR
V
N
D
V
E
E
L
V
K
K
Y
L
ESCLK
S
L
Q
I
I
R
K
E
D
LTMDNHLLG
L
Q
K
T
L
I
K
L
S
F
VN
S
N
Q
L
F
E
A
R
K
L
L
R
P
I
L
Q
D
N
A
N
N
N
V
Q
R
NIYNVKVDAKHLIEDIREYDVP
Y
H
V
R
V
S
I
D
K
DIRVG
K
W
Y
K
V
T
QQGFIEDTR
K
I
A
F
A
D
-
P
V
V
M
A
--
F
A
I
A
T
-----------------
T
---------
K
P
P
L
K
F
P
D
-
S
A
--------
V
D
Q
I
M
M
I
S
Y
M
I
D
G
E
G
F
L
I
T
N
R
--
E
--
I
--
I
S
E
D
I
--------
E
-
D
F
E
Y
-------
T
P
K
P
-
E
-------------
Y
--
P
G
F
F
----------------------
T
----------------------
I
--
F
N
E
N
--------
D
E
V
A
L
L
Q
--
R
F
F
E
H
I
R
D
V
R
P
-
T
V
I
-
S
T
F
N
-------------
G
---------
D
F
F
D
W
----------------
P
F
I
H
N
R
S
-
K
I
H
--
G
L
D
------
M
F
-
D
E
I
G
-------------
F
A
-
P
----
D
-----
A
----------------------------
E
----
G
E
Y
---
K
---
S
S
-----
Y
C
S
--
H
M
D
C
F
R
W
-----
V
----
K
---
R
D
S
Y
L
P
Q
G
S
-----------
Q
G
L
K
A
V
T
Q
S
K
L
---
G
----
Y
---
N
---
P
I
E
L
D
----
P
E
-
L
M
T
P
--
Y
A
F
EK
P
Q
H
L
S
E
Y
S
V
---
S
D
A
V
A
T
Y
-
Y
L
Y
-----
M
K
--------
Y
V
H
P
F
I
F
S
L
C
-----
T
I
I
P
L
N
P
D
E
T
L
R
K
G
T
G
T
L
C
E
M
L
L
M
-----
V
Q
A
------------
Y
Q
H
N
I
L
L
P
N
-
K
H
--------------
T
D
P
I
E
R
F
Y
------
D
-------------
G
H
L
L
E
S
E
T
Y
V
G
G
H
V
E
S
L
E
A
G
V
F
R
SD
L
K
N
E
F
K
I
D
P
S
A
I
D
E
L
L
Q
E
L
P
E
A
L
K
F
S
V
E
VENKSSVDKVTN
F
E
E
I
K
N
Q
I
T
Q
K
L
L
E
L
K
E
N
NI
R
N
E
L
P
L
I
Y
H
V
D
V
ASM
Y
P
N
I
M
T
T
N
RLQPDSIKAERDCASCTC
A
R
K
L
K
W
A
W
R
G
E
F
F
PSK
M
D
E
Y
N
M
I
K
R
A
L
Q
N
E
T
F
P
NKNKFSKKKVLTFDELS
Y
A
D
Q
V
I
H
I
K
K
R
L
T
E
Y
S
R
K
VYHRV
K
V
S
E
I
V
E
R
E
A
I
V
C
QRENP
F
Y
V
D
T
V
K
S
F
R
D
R
R
Y
E
F
K
G
L
A
K
T
W
K
G
N
L
S
KIDPSDKHAR
D
E
A
K
K
M
I
V
L
Y
D
S
L
Q
L
A
H
K
V
I
L
N
S
F
Y
G
YVMRKGSRWYS
M
E
M
A
G
I
T
C
L
T
G
A
T
I
I
Q
M
A
R
A
L
V
E
R
V
G
R
P
L
E
LDTD
G
I
W
C
I
L
PKSFP
E
T
Y
F
F
T
L
ENG
K
K
L
Y
L
S
Y
P
C
S
M
L
N
Y
R
V
H
Q
K
FTNHQYQELKDPLNY
I
Y
E
T
H
S
E
N
T
I
F
F
E
V
D
G
PYK
A
M
I
L
P
S
S
KEEG
K
G
I
K
K
R
Y
A
V
F
N
EDGSLAELKGFELKRRGEL
Q
L
I
K
N
F
Q
S
D
I
FKVFLEGDT
L
E
G
C
Y
S
A
V
A
S
V
C
N
R
W
L
D
V
L
D
S
HGLMLE
D
E
D
L
V
S
L
I
C
E
N
R
S
MSKTLKEYEGQKS
T
S
I
T
T
A
R
R
L
G
D
F
LGEDMVKDKG
L
Q
C
K
Y
I
I
S
SKPFNAPVTERAIPVAIFSAD
I
P
I
K
R
S
F
L
R
R
W
T
LDPSLEDLDIRTIID
W
G
Y
Y
R
E
R
L
G
S
A
I
Q
K
I
IT
I
P
A
A
L
Q
GVSNPVPRVEHP
D
W
L
K
R
K
I
AT
59
HHSearch
62.37
23%
-32
- C6 -
-
1S5J
-
DPOL1_SULSO
A:
[187-485]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
K
-
I
K
R
V
A
--
I
D
I
E
V
-----------
Y
T
P
V
K
----------------------------------------------
G
R
I
P
D
--
S
--
Q
KA
E
F
P
I
I
--------
S
I
A
L
A
G
-------
S
D
G
L
K
K
-------------
V
--
L
-
V
L
NRNDVNE
G
S
V
K
L
DG--------
I
----------------------
S
--
V
E
R
F
N
-------
T
E
Y
E
L
L
G
--
R
F
F
D
I
L
L
E
Y
-
P
-
I
V
L
-
T
-
F
N
-------------
G
---------
D
D
F
D
L
----------------
P
Y
I
Y
F
R
A
-
L
K
L
--
G
Y
F
---
P
E
E
I
--
P
I
D
V
---------------------------------------
A
G
---
K
---
D
-------
E
----
A
K
Y
L--
A
---
G
L
-----
H
I
D
--
L
Y
K
F
F
F
N
K
A
V
R
N
Y
AFEG
K
---
Y
N
E
-
Y
N
L
D
A
-----------
V
A
K
A
L
L
G
T
S
-----
K
----
V
---
D
---
T
L
----------
I
S
F
L
--
D
V
E
----
K
L
I
E
Y
N
F
---
R
D
A
E
I
T
L
-
Q
L
T
-----
T
F
--------
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
61.38
20%
-32
- C6 -
-
4PTF
2
DPOE_YEAST
A:
[288-508]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
D
-
P
V
V
M
A
--
F
D
I
E
T
-----------
T
K
P
P
-----------------------------------------------
L
K
F
P
D
--
S
--
A
--
V
D
Q
I
M
--------
M
I
S
Y
M
I
-------
D
G
E
G
-
F
-------------
L
--
I
-
T
N
REIISED
I
E
D
F
E
Y
T
PKPE
Y
P
G
F
F
----------------------
T
--
I
F
N
E
N
-------
D
E
V
A
L
L
Q
--
R
F
F
E
H
I
R
D
V
R
P
T
V
I
S
-
T
-
F
N
-------------
G
---------
D
F
F
D
W
----------------
P
F
I
H
N
R
S
-
K
I
H
--
G
L
D
---
M
F
D
E
I
-
G
F
A
P
-----------------------------
D
---------
A
E
---
G
---
E
-------
Y
----
K
S
S
---
Y
---
C
S
-----
H
M
D
--
C
F
R
W
V
K
R
-----
D
----
S
YLP
Q
G
S
-
Q
G
L
K
A
-----------
V
T
Q
S
K
L
G
Y
N
P
I
---
E
----
L
---
D
---
P
E
L
M
T
----
P
Y
-
A
F
E
---
K
P
Q
----
H
L
S
E
Y
S
V
---
S
D
A
V
A
T
Y
-
Y
L
Y
-----
M
K
--------
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
60.97
18%
-36
- C6 -
-
3IAY
2
DPOD_YEAST
A:
[246-469]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
P
-
L
R
I
M
S
--
F
D
I
E
C
-----------
A
G
R
I
-----------------------------------------------
G
V
F
P
E
--
P
--
E
--
Y
D
P
V
I
--------
Q
I
A
N
V
V
-------
S
I
A
G
-
A
KKP----------
F
I
R
N
-
V
F
----------------------
T
L
N
TCSPITG
S
------------
M
--
I
F
S
H
A
-------
T
E
E
E
M
L
S
--
N
W
R
N
F
I
I
K
V
D
P
D
V
I
I
-
G
-
Y
N
-------------
T
---------
T
N
F
D
I
----------------
P
Y
L
L
N
R
A
-
K
A
L
--
K
V
N
---
D
F
P
Y
F
-
G
R
L
K
-------------
T
V
-
K
Q
E
I
K
E
S
V
F
S
S
K
-
A
---------
Y
G
---
T
R
--
E
-------
T
----
K
N
V
---
N
IDG
R
L
-----
Q
L
D
--
L
L
Q
F
I
Q
R
E
----
Y
----
K
---
L
R
S
-
Y
T
L
N
A
-----------
V
S
A
H
F
L
G
E
Q
-------------------
S
I
I
S
----
D
L
-
Q
N
G
D
S
E
T
R
R
----
R
L
A
V
Y
C
L
---
K
D
A
Y
L
P
L
-
R
L
M
-----
E
K
--------
L
-------
M
A
-----
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
57.20
19%
-38
- C6 -
-
4M8O
1
DPOE_YEAST
A:
[281-495]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
D
-
P
V
V
M
A
--
F
A
I
A
T
-----------
T
K
P
P
-----------------------------------------------
L
K
F
P
D
--
S
--
A
--
V
D
Q
I
M
--------
M
I
S
Y
M
I
-------
D
G
E
G
-
F
-------------
L
--
I
-
T
N
REIISEDI
E
D
F
E
Y
T
PKPE
Y
P
G
F
F
----------------------
T
--
I
F
N
E
N
-------
D
E
V
A
L
L
Q
--
R
F
F
E
H
I
R
D
V
R
P
T
V
I
S
-
T
-
F
N
-------------
G
---------
D
F
F
D
W
----------------
P
F
I
H
N
R
S
-
K
I
H
--
G
L
D
---
M
F
D
E
I
---
G
F
--------------
A
-
P
------------
D
---------
A
E
---
G
---
E
-------
Y
----
K
S
S
---
Y
---
C
S
-----
H
M
D
--
C
F
R
W
V
K
R
-----
D
S---
Y
LP-
Q
G
S
-
Q
G
L
K
A
-----------
V
T
Q
S
K
L
G
Y
N
P
I
---
E
----
L
---
D
---
P
E
L
M
T
----
P
Y
-
A
F
E
---
K
P
Q
----
H
L
S
E
Y
S
V
---
S
D
A
V
A
T
Y
-
Y
L
Y
-----
M
K
--------
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
56.49
20%
10
- C4 -
-
4Q98
-
FIMA_PORGI
A:
[9-365]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
E
T
-
N
A
T
V
S
--
F
I
I
K
S
-----------
G
E
S
R
A
V
G
DDL
T
D
----
A
K
I
T
K
L
T
A
M
V
Y
--------
A
G
Q
V
Q
E
G
I
K
T
V
E
E
D
G
G
----
V
--
L
--
K
--
V
E
G
I
P
--------
C
K
S
G
------------
A
-
N
-------------
R
--
V
-
L
V
----------------------
V
----------------------
V
--
A
N
H
N
Y
ELTGKS
L
N
E
V
E
A
L
T
--
T
S
L
T
A
E
N
Q
N
A
K
-
N
L
I
M
T
-
G
K
-------------
S
---------
A
A
F
T
I
K
---------------
P
G
S
N
H
Y
G
-
Y
P
G
--
G
T
A
---
S
D
N
L
V
-
S
A
G
T
P
L
A
V
T
R
V
H
A
G
I
S
F
A
G
-
V
----
E
-----
V
-
N
M
--------
A
T
---
Q
---
Y
-------
Q
----
N
Y
Y
---
S
---
F
K
-----
P
A
D
A
K
I
A
A
L
V
A
K
-----
K
----
D
---
S
K
I
F
G
N
S
L
V
-----------
S
N
T
N
A
Y
L
Y
G
V
Q
---
T
----
P
---
A
---
G
L
Y
T
P
DAAG
E
T
-
Y
E
L
E
--
A
S
L
-----
N
T
N
Y
A
V
---
G
A
G
F
Y
V
L
E
S
K
Y
DASN
E
L
R
P
T
------
I
-------
L
C
-----
I
Y
G
K
L
L
D
K
D
G
N
P
L
T
E
P
A
L
T
D
A
I
N
A
GFCDG
D
G
T
------------
T
Y
---
Y
P
V
L
-
V
N
--------------
Y
D
G
N
G
Y
I
Y
------
S
GAITQGQN
K
I
V
R
N
N
H
Y
K
I
S
L
N
I
TGPGTNTPENPQPVQAN
L
N
V
T
C
Q
V
T
P
W
V
VVNQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
55.36
18%
-27
- C6 -
-
1QHT
-
DPOL_THES9
A:
[134-368]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
L
T
M
L
A
--
F
A
I
A
T
-----------
L
Y
H
E
G
-------------------------------------------------
E
E
--
F
--
G
--
T
G
P
I
L
--------
M
I
S
Y
A
D
-------
G
S
E
A
-
R
-------------
V
--
I
-
T
W
----------------------
K
K
I
D
L
P-----------------
Y
--
V
D
V
V
S
-------
T
E
K
E
M
I
K
--
R
F
L
R
V
V
R
E
K
D
P
D
V
L
I
-
T
-
Y
N
-------------
G
---------
D
N
F
D
F
----------------
A
Y
L
K
K
R
C
-
E
E
L
--
G
I
K
---
F
T
L
G
R
-
D
--
G
-------------
S
E
-
P
----
K
I
----
Q
-
R
---------
M
G
---
D
R
--
F
-------
A
----
V
E
V
K
--
G
---
R
I
-----
H
F
D
--
L
Y
P
V
I
R
R
-----
T
I---
N
---
L
P
T
-
Y
T
L
E
A
-----------
V
Y
E
A
V
F
G
K
P
K
E
---
K
----
V
---
Y
---
A
E
E
I
A
----
Q
A
-
W
E
S
G
E-
G
L
E
----
R
V
A
R
Y
S
M
---
E
D
A
K
V
T
Y
-
E
L
G
-----
R
E
--------
F
-------
F
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
54.93
20%
-13
- C6 -
-
1YT3
-
RND_ECOLI
A:
[1-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
N
Y
Q
M
I
TT
D
D
A
L
A
S
L
C
E
A
V
R
A
F
P
A
I
A
--
L
D
T
E
F
V
R
T
RTYYPQLG
L
I
Q
L
F
D
G
---------
E
H
L
A
L
I
D
P
-
L
G
--------
I
T
D
W
S
P
L
K
A
I
L
R
D
P
S
I
T
K
F
L
H
--
A
--
G
--
S
E
D
L
E
--------
V
F
L
N
V
F
GELPQP
L
I
D
T
Q
-
I
-------------
L
--
A
-
A
F
----------------------
C
----------------------
G
--
R
P
M
S
W
-------
G
F
A
S
M
V
E
--
E
Y
S
G
V
T
L
D
K
S
E
-
S
R
T
-
D
-
W
L
ARPLT
E
R
Q
C
E
Y
A
A
A
---------
D
V
W
Y
L
----------------
L
P
I
T
A
K
L
-
M
V
E
--
T
E
A
S
GW
L
P
A
A
L
-
D
E
C
R
-------------
L
M
-
Q
----
M
-----
R
-
R
Q
E
V
V
A
PEDA
W
R
---
D
---
I
-------
T
----
N
A
W
QL-
R
---
T
R
-----
Q
L
A
--
C
L
Q
L
L
A
D
-----
W
----
R
---
L
R
K
A
R
E
R
D
L
AVNFVVR
E
E
H
L
W
S
V
A
R
Y
M
P
G
S
L
---
G
----
E
L
D
S
L
---
G
L
S
G
S
----
E
I
R
F
H
G
K
--
T
L
L
----
A
L
V
E
K
A
Q
T
LP
E
D
A
L
P
Q
P
-
M
L
N
-----
L
M
DMPG
Y
R
K
A
F
-------
K
A
-----
I
K
S
L
I
T
D
V
S
E
T
H
K
I
S
--
A
E
L
L
A
S
R
-----
R
Q
I
------------
N
Q
---
L
L
N
W
H
W
K
LKPQNNLPELISG
W
R
G
E
L
M
A
E
A
------
L
-------------
H
N
L
L
Q
E
Y
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
54.17
19%
-5
- C6 -
-
1TGO
-
DPOL_THEGO
A:
[133-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
-
L
K
M
L
A
--
F
D
I
E
T
-----------
L
Y
H
E
G
-------------------------------------------------
E
E
--
F
--
A
--
E
G
P
I
L
--------
M
I
S
Y
A
D
-------
E
E
G
A
-
R
-------------
V
--
I
-
T
W
----------------------
K
N
I
D
L
P-----------------
Y
--
V
D
V
V
S
-------
T
E
K
E
M
I
K
--
R
F
L
K
V
V
K
E
K
D
P
D
V
L
I
-
T
-
Y
N
-------------
G
---------
D
N
F
D
F
----------------
A
Y
L
K
K
R
S
-
E
K
L
--
G
V
K
---
F
I
L
G
R
-
E
--
G
-------------
S
E
-
P
----
K
-----
I
Q
R
---------
M
G
---
D
R
--
F
-------
A
----
V
E
V
K
--
G
---
R
I
-----
H
F
D
--
L
Y
P
V
I
R
R
-----
T
I---
N
---
L
P
T
-
Y
T
L
E
A
-----------
V
Y
E
A
I
F
G
Q
P
K
E
---
K
----
V
---
Y
---
A
E
E
I
A
----
Q
A
-
W
E
T
G
E-
G
L
E
----
R
V
A
R
Y
S
M
---
E
D
A
K
V
T
Y
-
E
L
G
-----
K
E
--------
F
-------
F
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
48.29
13%
18
- C6 -
-
1NOZ
-
DPOL_BPT4
A:
[2-370]
-----------------------------------------------------------------------------------------------------------------------------------------------DEFYI
S
I
E
T
V
GN
N
I
V
E
R
Y
IDENG
K
E
R
T
R
E
V
EYLPTMFRHCKEG
K
N
C
A
P
Q
K
F
PS
M
K
D
A
R
D
W
M
K
RG
M
N
D
F
K
L
A
Y
I
S
D
T
YGSE
I
V
Y
D
R
K
F
-
V
R
V
A
N
--
C
D
I
E
V
-----------
T
G
-
D
K
F
P
DPMKAEYEI
D
A
I
T
H
Y
D
S
-
I
D
--------
D
R
F
Y
V
F
D
L
L
N
S
M
Y
G
S
V
S
K
W
D
A
--
K
--
L
--
A
A
K
L
D
--------
C
E
G
G
D
E
-------
V
P
Q
E
-
I
-------------
L
--
D
-
R
V
----------------------
I
----------------------
Y
--
M
P
F
D
--------
N
E
R
D
M
L
M
--
E
Y
I
N
L
W
E
Q
K
R
P
-
A
I
F
-
T
G
W
N
-------------
I
---------
E
G
F
D
V
----------------
P
Y
I
M
N
R
V
-
K
M
I
LG
E
R
S
---
M
K
R
F
S
-
P
I
G
R
-------------
V
K
-
S
----
K
-----
L
---------------------------------
S
K
E
---
I
---
Y
S
I
D
GVS
I
L
D
--
Y
L
D
L
Y
K
K
-----
F
----
A
---
F
T
N
L
P
S
F
S
L
-----------
E
S
V
A
Q
H
E
T
K
K
G
---
K
----
L
---
P
---
Y
D
G
P
I
----
N
K
-
L
R
E
T
--
N
H
Q
----
R
Y
I
S
Y
N
I
---
I
D
V
E
S
V
Q
-
A
I
D
-----
K
I
--------
R
-------
G
F
-----
I
D
L
V
L
S
M
S
Y
Y
A
K
M
---
P
F
S
G
V
M
S
P
-----
I
K
T
------------
W
D
---
A
I
I
F
-
N
S
--------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
46.67
17%
11
- C1 -
-
5ANZ
3
?
A:
[45-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQS
F
E
Q
W
R
D
A
F
R
-
Q
Q
A
L
A
G
G
I
D
A
Q
T
-----------
F
D
R
A
F
A
G
VQPD-----
P
A
V
V
E
A
D
R
-
S
Q
PE
F
T
R
P
V
W
K
Y
L
E
G
A
L
D
P
L
R
V
R
Q
G
Q
A
R
L
A
Q
H
A
R
--
I
--
L
G
E
V
D
A
R
Y
AVD
A
D
A
V
V
A
I
W
-------
G
M
E
S
-
N
YGSHMGNKN
V
I
R
S
L
--
A
-
T
L
----------------------
A
----------------------
Y
EG
R
R
P
E
F
-------
A
H
A
Q
L
L
A
A
L
K
I
L
Q
H
G
D
V
P
A
S
-
F
M
I
G
S
-
W
A
-------------
G
AMGQTQFI
P
T
T
H
N
Q
YAVDFDGDGKRDIWGS
P
G
D
A
L
A
S
-
T
A
N
--
Y
L
K
---
A
S
G
W
I
-
A
G
Q
P
-------------
W
G
-
F
----
E
-----
V
-
R
---------
L
P
---
A
---
G
-------
F
----
D
-
Y
---
S
---
L
A
-----
E
L
T
--
I
R
K
P
L
G
E
-----
W
----
Q
---
G
M
G
V
Q
G
V
N
G
-----------
G
P
L
P
S
G
L
S
G
E
Q
---
A
S
L
L
L
P
---
A
---
G
H
R
G
P
----
A
F
-
L
V
L
H
--
N
F
R
----
A
I
L
K
Y
N
N
---
S
S
A
Y
A
L
A
-
V
G
L
-----
L
A
--------
D
-------
S
F
K
GGGR
I
V
G
A
W
P
L
E
D
V
P
L
S
R
S
Q
R
I
E
L
Q
R
Q
L
-----
A
A
R
GHDPGAVDGIIG
A
N
---
T
R
K
A
-
I
R
--------------
A
C
Q
Q
E
F
G
W
PADGYP
T
-------------
P
A
L
L
D
R
L
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
46.45
20%
3
- C6 -
-
3K57
1
DPO2_ECOLI
A:
[201-353]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
-------
S
R
P
Q
L
L
E
--
K
L
N
A
W
F
A
N
Y
D
P
D
V
I
I
-
G
-
W
N
-------------
V
---------
V
Q
F
D
L
----------------
R
M
L
Q
K
H
A
-
E
R
Y
--
R
L
P
---
L
R
L
G
R
-
D
--
N
----------------
S
----
E
-----
L
-
E
---------
W
R
---
E
---
H
GFKNG
V
F
F
----
A
Q
A
---
K
G--
R
L
-----
I
I
D
--
G
I
E
A
L
K
S
-----
A
FW--
N
---
F
S
S
-
F
S
L
E
T
-----------
V
A
Q
E
L
L
G
E
G
K
S
I--
D
----
N
---
P
W
D
R
M
D
E
I
D
----
R
R
-
F
A
E
---
D
K
P
----
A
L
A
T
Y
N
L
---
K
N
C
E
L
V
T
-
Q
I
F
-----
H
K
--------
T
-------
E
I
-----
M
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
45.97
27%
-130
- C7 -
-
2JGU
-
DPOL_PYRFU
A:
[149-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
E
F
G
K
--
G
--
P
-----
I
I
--------
M
I
S
--
Y
-------
A
D
E
N
-
E
-------------
A
--
R
-
V
I
----------------------
T
WKNIDLP---------------
Y
--
V
E
S
V
S
-------
T
E
K
E
M
I
K
--
R
F
L
R
I
I
R
E
K
D
P
D
I
I
V
-
T
-
Y
N
-------------
G
---------
D
S
F
D
F
----------------
P
Y
L
A
K
R
A
-
E
K
L
--
G
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
44.75
38%
-119
- C7 -
-
4M8O
-
DPOE_YEAST
A:
[355-408]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
L
L
Q
--
R
F
F
E
H
I
R
D
V
R
P
-
T
V
I
-
S
T
F
N
-------------
G
---------
D
F
F
D
W
----------------
P
F
I
H
N
R
S
-
K
I
H
--
G
L
D
------
M
F
-
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
43.28
20%
21
* C6 *
-
3K59
1
DPO2_ECOLI
A:
[201-353]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
-------
S
R
P
Q
L
L
E
--
K
L
N
A
W
F
A
N
Y
D
P
D
V
I
I
-
G
-
W
N
-------------
V
---------
V
Q
F
D
L
----------------
R
M
L
Q
K
H
A
-
E
R
Y
--
R
L
P
---
L
R
L
G
R
-
D
--
N
----------------
S
----
E
-----
L
-
E
---------
W
R
---
E
---
H
GFKNG
V
F
F
----
A
Q
A
---
K
G--
R
L
-----
I
I
D
--
G
I
E
A
L
K
S
-----
A
FW--
N
---
F
S
S
-
F
S
L
E
T
-----------
V
A
Q
E
L
L
G
E
G
K
S
---
D
----
N
---
P
W
D
R
M
D
E
I
D
----
R
R
-
F
A
E
---
D
K
P
----
A
L
A
T
Y
N
L
---
K
N
C
E
L
V
T
-
Q
I
F
-----
H
K
--------
T
-------
E
I
-----
M
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
42.89
22%
15
- C6 -
-
1NOY
-
DPOL_BPT4
A:
[188-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
-------
N
E
R
D
M
L
M
--
E
Y
I
N
L
W
E
Q
K
R
P
A
I
F
T
-
G
-
W
N
-------------
I
---------
E
G
F
D
V
----------------
P
Y
I
M
N
R
V
-
K
M
I
L-
G
E
R
---
S
M
K
R
F
S
P
I
G
R
-------------
V
K
-
S
K
L
L
-
Q
-----
N
-
M
---------
Y
G
---
S
-----------
K
----
E
I
Y
S
ID
G
---
V
S
-----
I
L
D
--
Y
L
D
L
Y
K
K
-----
F
AFT-
N
---
L
P
S
-
F
S
L
E
S
-----------
V
A
Q
H
E
T
K
K
G
K
L
---
P
----
Y
---
D
----
G
P
I
N
----
K
L
-
R
E
T
---
N
H
Q
----
R
Y
I
S
Y
N
I
---
I
D
V
E
S
V
Q
-
A
I
D
-----
K
I
--------
R
-------
G
F
-----
I
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
42.62
22%
-3
- C6 -
-
1NOZ
-
DPOL_BPT4
A:
[188-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
-------
N
E
R
D
M
L
M
--
E
Y
I
N
L
W
E
Q
K
R
P
A
I
F
T
-
G
-
W
N
-------------
I
---------
E
G
F
D
V
----------------
P
Y
I
M
N
R
V
-
K
M
I
L-
G
E
R
---
S
M
K
R
F
S
P
I
G
R
-------------
V
K
-
S
K
L-------------------------
S
-----------
K
----
E
I
Y
S
I
D
G
---
V
S
-----
I
L
D
--
Y
L
D
L
Y
K
K
-----
F
AFT-
N
---
L
P
S
-
F
S
L
E
S
-----------
V
A
Q
H
E
T
K
K
G
K
L
---
P
----
Y
---
D
----
G
P
I
N
----
K
L
-
R
E
T
---
N
H
Q
----
R
Y
I
S
Y
N
I
---
I
D
V
E
S
V
Q
-
A
I
D
-----
K
I
--------
R
-------
G
F
-----
I
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
41.60
16%
-26
- C6 -
-
4QCL
-
DPOLA_HUMAN
A:
[277-466]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
-------
T
E
R
T
L
L
G
--
F
F
L
A
K
V
H
K
I
D
P
D
I
I
V
-
G
-
H
N
-------------
I
---------
Y
G
F
E
L
----------------
E
V
L
L
Q
R
I
-
N
V
C
--
K
A
P
---
H
W
S
K
I
---
G
R
--------------
L
-
K
----
R
-----
S
-
N
---------
M
P
KLG----
F
-------
G
----
E
R
N
A
T
C
G
---
R
M
-----
I
C
D
--
V
E
I
S
A
K
E
-----
L
I---
R
---
C
K
S
-
Y
H
L
S
E
-----------
L
V
Q
Q
I
L
K
T
E
R
V
---
V
----
I
---
P
---
M
E
N
I
Q
----
N
M
-
Y
S
E
S
S
-
Q
L
L
----
Y
L
L
E
H
T
W
---
K
D
A
K
F
I
L
-
Q
I
M
-----
C
E
--------
L
-------
N
V
-----
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------