@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKL5: (2017-10-27 )
MSNTQPDFLADEFLLDHYVGKTPLVRLQRLACHTQATVLAKLEGNNPAGSVKDRPAYNMIMQAEKRGQIKPGDTLVEATSGNTGIALAMVAAMRGYKMKLIMPGNSSQERKDAMRAYGAELIEAPNMEAARDMALQMQAEGLGLVLNQFGNPDNVEAHYLTTGPEIWKQTGGKITHFVSSMGTTGTIMGVSKYLKEQNPDIQIIGLHPSEGSNIAGIRRWPQEYLPTIFEPKRVDQIMGIPQIEAEKTARRLAREEGISAGTSSGGAVWASVKIAEENPDAVIVCIICDRGDRYLSTGLFSVQD
Atome Classification :
(23 SA)
.........10........20........30-...-------......40........50........60........70-...-.....80........90........100.......110.......120---.---..---....130.....-..140...-----..-.-...150.......160.......170.......180.......190....--...200.......210.....-------..220.-------------......230.......240.......250.......260.......270...--.--..--.280--.........290.......300..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSNTQP
D
F
L
A
D
E
F
L
L
D
H
YVGK
T
P
L
V
R
L
Q
R
L
--
A
C
H-------T
Q
A
T
V
L
A
K
LEGNNPAGSVKDR
P
A
Y
N
M
I
M
Q
AEKRGQIKP-G
D
T
-
L
V
E
ATSGNT
G
I
A
L
A
M
V
A
A
MRG
Y
K
M
K
L
I
MPGNS
S
Q
E
R
K
D
A
M
R
A
Y
G
A
E
L
I---E---AP---
N
M
E
A
A
R
D
M
A
L
Q
M
-QAE--
G
L
G
-----
L
V
-
L
-
N
QFGNPDN
V
E
A
H
Y
LTT
G
P
E
I
W
K
QTGG
K
I
T
H
F
V
S
SMGTT
G
T
I
M
G
V
S
K
Y
L
KE--QNP
D
I
Q
I
I
G
LHPSEGSN
I
A
G
I
-------
R
R
W
P
Q
E
-------------
Y
L
P
T
IF
E
P
K
R
V
D
Q
I
MGIPQI
E
A
E
K
T
A
R
R
L
A
R
E
EGISAGTSSG
G
A
V
W
A
S
V
K
I
A--E--EN--P
D
----
A
V
I
V
C
I
I
CDRGDR
Y
L
S
TGLFSVQD
110
HHSearch
93.33
65%
-4
- C4 -
-
2V03
3
CYSM_ECOLI
A:
[4-294]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
--
G
P
D
-------
N
G
S
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
---
L
---
V
T
KEQ
G
M
E
G
A
R
D
L
A
L
E
M
-
A
N
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
--
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
T
E
-------------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
A
--
A
N
--
P
D
----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
G
E
--
3
PsiBlast_PDB
91.91
64%
-1
- C4 -
-
2V03
3
CYSM_ECOLI
A:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
--
G
P
D
-------
N
G
S
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
E
M
-
A
N
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
--
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
T
E
-------------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
A
--
A
N
--
P
D
----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
21
PsiBlast_CBE
91.38
64%
-7
- C4 -
-
2BHS
1
CYSM_ECOLI
D:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
--
G
P
D
-------
N
G
S
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
E
M
-
A
N
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
--
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
T
E
-------------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
K
--
A
N
--
P
D
----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
109
HHSearch
91.28
63%
-5
- C4 -
-
2JC3
1
CYSM_SALTY
A:
[4-293]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
I
--
G
P
D
-------
N
G
S
E
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
---
L
---
V
T
KEQ
G
M
E
G
A
R
D
L
A
L
A
M
-
S
E
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
--
Q
E
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
A
E
-------------
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
R
--
A
T
--
P
G
----
A
I
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
G
---
27
PsiBlast_CBE
90.91
62%
-4
- C4 -
-
2JC3
1
CYSM_SALTY
E:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
I
--
G
P
D
-------
N
G
S
E
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
A
M
-
S
E
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
--
Q
E
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
A
E
-------------
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
R
--
A
T
--
P
G
----
A
I
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
25
PsiBlast_CBE
90.83
62%
-0
- C4 -
-
2JC3
1
CYSM_SALTY
G:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
I
--
G
P
D
-------
N
G
S
E
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
A
M
-
S
E
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
--
Q
E
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
A
E
-------------
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
R
--
A
T
--
P
G
----
A
I
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
2
PsiBlast_PDB
90.75
64%
-4
- C4 -
-
2BHS
1
CYSM_ECOLI
A:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
--
G
P
D
-------
N
G
S
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
E
M
-
A
N
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
--
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
T
E
-------------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
K
--
A
N
--
P
D
----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
26
PsiBlast_CBE
90.74
62%
-3
- C4 -
-
2JC3
1
CYSM_SALTY
F:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
I
--
G
P
D
-------
N
G
S
E
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
A
M
-
S
E
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
--
Q
E
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
A
E
-------------
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
R
--
A
T
--
P
G
----
A
I
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
29
PsiBlast_CBE
90.65
62%
-4
- C4 -
-
2JC3
1
CYSM_SALTY
C:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
I
--
G
P
D
-------
N
G
S
E
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
A
M
-
S
E
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
--
Q
E
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
A
E
-------------
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
R
--
A
T
--
P
G
----
A
I
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
28
PsiBlast_CBE
90.63
62%
-4
- C4 -
-
2JC3
1
CYSM_SALTY
D:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
I
--
G
P
D
-------
N
G
S
E
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
A
M
-
S
E
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
--
Q
E
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
A
E
-------------
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
R
--
A
T
--
P
G
----
A
I
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
30
PsiBlast_CBE
90.52
62%
-3
- C4 -
-
2JC3
1
CYSM_SALTY
B:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
I
--
G
P
D
-------
N
G
S
E
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
A
M
-
S
E
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
--
Q
E
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
A
E
-------------
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
R
--
A
T
--
P
G
----
A
I
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
23
PsiBlast_CBE
90.52
64%
-5
- C4 -
-
2BHS
1
CYSM_ECOLI
B:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
--
G
P
D
-------
N
G
S
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
E
M
-
A
N
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
--
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
T
E
-------------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
K
--
A
N
--
P
D
----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
22
PsiBlast_CBE
90.05
64%
-0
- C4 -
-
2BHS
1
CYSM_ECOLI
C:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
--
G
P
D
-------
N
G
S
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
E
M
-
A
N
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
--
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
T
E
-------------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
K
--
A
N
--
P
D
----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
24
PsiBlast_CBE
90.04
62%
-3
- C4 -
-
2JC3
1
CYSM_SALTY
H:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
I
--
G
P
D
-------
N
G
S
E
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
LVT
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
A
M
-
S
E
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
--
Q
E
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
A
E
-------------
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
R
--
A
T
--
P
G
----
A
I
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
4
PsiBlast_PDB
89.85
62%
-1
- C4 -
-
2JC3
1
CYSM_SALTY
A:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
I
--
G
P
D
-------
N
G
S
E
I
W
V
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
A
M
-
S
E
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
R
Q
T
S
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
L
R
E
--
Q
E
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
A
E
-------------
Y
M
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
N
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
R
--
A
T
--
P
G
----
A
I
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
1
PsiBlast_PDB
87.27
64%
3
- C4 -
-
2BHT
-
CYSM_ECOLI
A:
[4-292]
--------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
--
G
P
D
-------
N
G
S
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
R
I
K
P
-
G
D
V
-
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
---
E
Q
---
G
M
E
G
A
R
D
L
A
L
E
M
-
A
N
R
--
G
E
G
-----
K
L
-
L
-
D
Q
F
N
N
P
D
N
P
K
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
E
F
M
R
E
--
Q
S
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
I
P
G
I
-------
R
R
W
P
T
E
-------------
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
--
K
--
A
N
--
P
D
----
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----
132
Fugue
81.11
45%
-2
- C4 -
-
1OAS
1
CYSK_SALTY
A:
[1-315]
-
S
K
I
Y
E
D
N
S
L
T
-------
I
G
H
T
P
L
V
R
L
N
R
I
--
G
----------
N
G
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
-
G
V
E
-
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
---
L
T
EG
A
K
---
G
M
K
G
A
I
Q
K
A
E
E
I
-
V
A
S
D
P
Q
K
Y
-----
L
L
-
L
-
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
TK
G
K
T
D
L
I
T
V
A
V
E
P
T
D
S
P
V
I
A
Q
A
-------
L
A
G
E
E
I
K
P
G
P
H
KIQGIGAG
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
E
--
S
F
--
T
N
----
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
118
HHSearch
80.55
42%
-17
- C4 -
-
2Q3D
1
CYSK_MYCTU
A:
[10-309]
--------------
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
--
T
D
G
-------
A
V
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
-
D
T
I
-
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
---
L
---
T
P
GAD
G
M
S
G
A
I
A
K
A
E
E
L
-
A
K
T
--
D
Q
R
-----
Y
F
-
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
--
R
K
P
S
A
R
F
V
A
V
E
P
A
A
S
P
V
L
S
G
G
Q
K
G
P
H
PI
Q
G
I
G
A
G
-------------
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
--
R
--
R
P
EN
A
G
----
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
T
P
L
F
A
---
111
HHSearch
80.12
42%
-14
- C4 -
-
2Q3B
4
CYSK_MYCTU
A:
[9-303]
-------------
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
--
T
D
G
-------
A
V
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
-
D
T
I
-
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
---
L
---
T
P
GAD
G
M
S
G
A
I
A
K
A
E
E
L
-
A
K
T
--
D
Q
R
-----
Y
F
V
P
-
Q
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
--
R
K
P
S
A
R
F
V
A
V
E
P
A
A
S
P
V
L
S
G
G
Q
K
G
P
HPI
Q
G
I
G
A
G
-------------
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
--
R
--
R
P
EN
A
G
----
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------
115
HHSearch
79.49
43%
3
- C4 -
-
2ISQ
1
CYSK1_ARATH
A:
[6-308]
-------------
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
--
A
E
G
-------
C
V
G
R
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G
E
S
V
-
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
---
L
---
T
D
PAK
G
M
K
G
A
I
A
K
A
E
E
I
-
L
A
K
T-
P
N
G
-----
Y
M
-
L
-
Q
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
--
Q
N
A
N
V
K
L
Y
G
V
E
P
V
E
S
A
I
L
S
G
G
K
P
G
P
H
KI
Q
G
I
G
A
G
-------------
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
--
Q
--
R
P
EN
A
G
----
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
V
L
F
D
A
--
51
PsiBlast_CBE
70.50
41%
25
- C4 -
-
4LMB
3
?
A:
[14-315]
--------------
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
V
A
E
G
-------
V
K
A
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
-
D
K
T
I
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
---
L
---
T
P
GSQ
G
M
E
G
A
I
T
R
A
E
E
I
V
E
N
T
--
P
N
A
-----
Y
S
-
L
-
Q
Q
F
R
N
P
A
N
P
K
I
H
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
P
--
R
R
P
Q
F
Q
A
I
A
V
E
P
S
N
S
P
V
L
S
G
G
-------
Q
P
G
P
H
K
IQGIGAG------
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
--
K
RP
E
N
--
E
D
----
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
----
98
PsiBlast_CBE
67.06
36%
15
- C4 -
-
5I6D
3
CYSM_MYCTU
A:
[14-310]
------------------
L
G
N
T
P
L
V
G
L
Q
R
L
--
S
P
R
WDDGRD
G
P
H
V
R
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
-
G
A
T
-
I
L
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
---
F
---
S
-----------
T
A
V
A
T
-
A
K
E
--
L
A
A
T
N
PSW
V
M
-
L
-
Y
Q
Y
G
N
P
A
N
T
D
S
H
Y
C
G
T
G
P
E
L
L
A
D
L
-
P
E
I
T
H
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
E
--
H
V
A
N
V
K
I
V
A
A
E
P
R
----------------------------------
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
--
A
--
G
A
--
L
A
A
GER
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
---
97
PsiBlast_CBE
66.24
36%
16
- C4 -
-
5I6D
3
CYSM_MYCTU
B:
[14-310]
------------------
L
G
N
T
P
L
V
G
L
Q
R
L
--
S
P
R
WDG----
P
H
V
R
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
-
G
A
T
-
I
L
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
---
F
---
S
A
----
A
E
G
G
S
N
T
A
V
A
T
-
A
K
E
--
L
A
A
T
N
PSW
V
M
-
L
-
Y
Q
Y
G
N
P
A
N
T
D
S
H
Y
C
G
T
G
P
E
L
L
A
D
L
-
P
E
I
T
H
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
E
--
H
V
A
N
V
K
I
V
A
A
E
P
R
----------------------------------
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
--
A
--
G
A
--
L
A
A
G
E
R
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
---