@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKL6: (2017-10-27 )
MSNFNKTLSKRLRLNHAYGQLIALIFVPIMILTCVGAFLVLTETSRSAKQQQLHHASAILARYNQIAKDLYTLVELQPDEYDHAQHIMQSMFSEKNLKRAALIDSNGQTYLSIGYRDNRYWPNSTQNDNFFGPISYNHNNIYGVRIIDTAGKPPVWLLIEMDNQPLELARYRILIALVITGLMTLLLLLLCLNFYSRRWIAPMYEIRMQLQRLNADTLDQHIVINSSGELRLLQRDIANVVKRLHFSFLELKEHTEQTEEDLRRTLDTLEVQNITYRQARDQAISSNQAKSVFLANISHELRTPLNSIDGFIHLLLRQQNLSNEQNLYLQTIRKSSAHLLALINDVLDFSKIDAGKLELETAPFDLEEAVFDVMDMLSPLAAQKHIAMAFYYADNIPQQVIGDALRFKQILTNLISNAIKFTPDGEIIVRVRMEHDDIGQCLLHFSVQDSGIGLSGTDRKKLFESFSQGDASVTRQFGGTGLGLAISKQLVHLMHGQIGFEDNQERAPTEKGSTFWFTAQFAVDEEHEIEHPHFEHLQVVSYLAHPATASVLRYYLENYQVPHIETQSILDLFSRLKHLDQKDNTWLIVDHSGDTEALLKEIRSRYQGNLAVYGYQMTLEPNMLTEYRARPLYQPLSRSGLIQLLSDQPIFEEEQQDFNGQGLHILAVDDHLPNLIVLEALLGELNVKTTKALSGQEALNIIQERIDQKLKPFDLVFMDIQMPVMSGIDTTRAIRSLESTLDGEMQLPIIALTAHALADEKQKLLKVGMNDYVTKPIQMEQIIQILTQWTKNNFTAQNLAKDHHVVAEALDPEILNWQQSLQLTANKEDLAQDLLKMLIDSFPTELEEIQQLIELEDFPQLEHVLHRLYGATRYVGTPKLQQVTGDFEQFISTLRKERRRADDGFIEEVMRRFDELGLVIKEVESAAHQILVIPD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210......---.220.......230----------------.......240.......250.......260.....-----------------------------------..-----------270-------...-----..--.------------------.----------------..280.......290.......300.......310--....---....320-...-.....330.......340.......350.......360.......---370.......380...-----....390.......400-------.......410.......420----..-.-...-.430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
N
F
N
K
T
L
S
K
R
L
R
L
N
H
A
Y
G
Q
L
I
A
L
I
F
V
P
I
M
I
L
T
C
V
G
A
F
L
V
LTETSR
S
A
K
Q
Q
Q
L
H
H
A
S
A
I
L
A
R
Y
N
Q
I
A
K
D
L
Y
T
L
V
ELQPDE
Y
D
H
A
Q
H
I
M
Q
S
M
F
S
EKNL
K
R
A
A
L
IDSNG
Q
T
Y
L
S
I
GYRDNRYWPNSTQND
N
F
F
G
P
I
S
YNHN
N
I
Y
G
V
R
I
IDTAGKP
P
V
W
L
L
I
EMDNQ
P
L
E
L
A
R
Y
R
I
L
I
A
L
V
I
T
G
L
M
T
L
L
L
L
L
L
C
L
N
F
Y
SRRWI
A
P
M
Y
E
I
R
M
Q
L
Q
RL
N
A
D
TL---D
Q
H
I
V
INSSG
E
L
R
L
----------------
L
Q
R
D
I
A
N
V
V
K
R
L
H
F
S
F
L
E
L
K
E
H
T
E
Q
T
E
E
D
L
R
R
T
L
D
-----------------------------------
T
L
-----------E---------VQN-----I
T
--
Y
------------------
R
----------------
Q
A
R
D
QAISSNQA
K
S
V
F
L
A
N
I
S
H
E
L
R
T
P
L
N
S
I
D
G
F
---
I
H
L
L
---
L
R
QQN-L-SNE-
Q
N
L
Y
L
Q
T
I
R
KSS
A
H
L
L
A
L
I
N
D
V
L
D
F
SKIDAG
K
L
E
LETAPF
D
L
E
E
A
---
V
F
D
V
M
D
M
L
S
P
L
A
AQK
H
-----
I
A
M
A
F
Y
YADNI
P
Q
Q
V
I
G
-------
D
A
L
R
F
K
Q
I
L
T
N
L
I
S
N
A
I
K
FT----PD-G-
E
I
I
-
V
R
V
R
MEHD
D
I
G
Q
C
L
L
H
F
S
VQDSGIGLSG
T
D
R
K
K
L
F
E
S
F
SQG
D
A
S
V
T
R
Q
FGGT
G
L
G
L
A
I
S
K
Q
L
V
H
L
M
H
GQIGFEDNQERAPTEKG
S
T
F
W
F
T
A
Q
F
AVDEEHEIEHP
H
F
E
H
L
Q
V
V
S
Y
LAHP
A
T
A
S
V
L
R
Y
Y
L
E
NYQVPHI
E
T
Q
S
I
L
D
L
F
S
R
L
K
H
LDQKDN
T
W
L
I
V
DHSG
D
T
E
A
L
L
K
E
I
R
S
R
YQG
N
L
A
V
Y
G
Y
Q
M
T
LEP
N
M
L
T
E
Y
RARPLYQP
L
S
R
S
G
L
I
Q
L
LSDQPI
F
E
E
E
Q
QDFNGQ
G
L
H
I
L
A
VDDHL
P
N
L
I
V
L
E
A
L
L
G
ELN
V
K
T
TKALS
G
Q
E
A
L
N
I
I
Q
E
R
I
DQKLKP
F
D
L
V
F
M
D
IQ
M
P
V
MSGI
D
T
T
R
A
I
R
S
L
E
S
TLDGEMQ
L
P
I
I
A
L
T
A
H
A
L
A
D
E
K
Q
K
L
L
K
VG
M
N
DYVTKPI
Q
M
E
Q
I
I
Q
I
L
T
Q
W
TKNNF
T
A
Q
N
L
A
K
D
H
H
V
V
A
E
AL
D
P
E
I
L
N
W
Q
Q
S
L
QLTA
N
K
E
D
L
A
Q
D
L
L
K
M
L
I
D
SF
P
T
E
L
E
E
I
Q
Q
L
I
ELED
F
P
Q
L
E
H
V
L
H
R
L
YGATRYVGT
P
K
L
Q
Q
V
T
G
D
F
E
Q
F
I
S
T
L
R
K
E
RRRAD
D
G
F
I
E
E
V
M
R
R
F
D
E
L
G
L
V
I
K
E
V
E
SAA
H
Q
I
L
V
IPD
118
HHSearch
86.44
21%
-
- C3 -
-
4I5S
-
?
B:
[28-434]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
Y
R
E
Y
K
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
---
T
D
K
L
K
V
E
D
N
S
D
L
S
E
----------------
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
RSGKITVIN
D
M
A
Q
K
Q
L
NVT
R
E
Q
A
L
E
CNIL
D
I
LDDDSY
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
EYD
E
F
I
T
L
R
I
R
F
A
L
N
R
R
ESGFIS
G
L
I
A
V
L
----------------
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
---
L
E
A
L
---
D
D
G
A
L
-
T
-
E
S
V
-
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
I
D
N
Q
T
S
H
L
D
V
E
L
T
N
F
T
A
F
---
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
-------
E
I
I
R
D
Y
P
-
D
K
S
V
W
I
E
I
-------
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
----
P
D
G
G
-
K
V
T
-
I
T
M
Q
T
T
-----
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
------
T
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
-----
G
E
G
S
T
F
T
I
V
L
P
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Fugue
71.38
20%
-
- C3 -
-
4I5S
-
?
A:
[37-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
YMT
D
G
V
L
A
T
D
R
S
G
K
I
T
V
IN
D
M
A
Q
K
Q
L
NVTREQA
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
-----------------------------------
E
F
-----------
I
---------
T
L
R
-----
I
R
--
F
------------------
A
L
NRRESGFIS
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
---
L
E
A
L
---
D
D
G
A
L
-
T
-
E
S
V
-
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
---
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
S
-----
T
E
I
I
R
D
Y
P
D
K
-
S
V
W
I
E
I
-------
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
----
P
D
G
G
-
K
V
T
-
I
T
M
Q
T
T
D
T
Q
-----
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
-------
R
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
-----
E
G
S
T
F
T
I
V
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.86
29%
-98
- C3 -
-
5LFK
2
?
A:
[83-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
---
T
A
L
L
---
R
R
R
S
G
-
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
---
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
G
-
P
W
P
L
Y
G
-------
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-----
H
-
T
-
K
I
E
-
V
G
F
A
V
D
K
D
G
I
-----
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.38
29%
-111
- C3 -
-
4BIX
1
CPXA_ECOLI
A:
[83-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
---
T
A
L
L
---
R
R
R
S
G
-
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
---
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
G
-
P
W
P
L
Y
G
-------
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-----
H
-
T
-
K
I
E
-
V
G
F
A
V
D
K
D
G
I
-----
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.28
29%
-95
- C3 -
-
4BIW
2
CPXA_ECOLI
A:
[83-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
---
T
A
L
L
---
R
R
R
S
G
-
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
---
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
G
-
P
W
P
L
Y
G
-------
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-----
H
-
T
-
K
I
E
-
V
G
F
A
V
D
K
D
G
I
-----
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.25
30%
2
- C3 -
-
5C93
1
?
A:
[16-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
---
I
E
A
L
---
S
D
G
A
W
-
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
----
L
K
K
D
-----
D
N
P
A
K
Y
Y
T
--
I
K
R
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
-
G
-
G
V
V
T
C
R
L
L
E
T
H
N
---
Q
V
I
I
--
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
-----
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.05
31%
-11
- C3 -
-
4U7O
1
?
A:
[38-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
---
I
E
A
L
---
S
D
G
A
W
-
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
----
L
K
K
D
-----
D
N
P
A
K
Y
Y
T
--
I
K
R
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
-
G
-
G
V
V
T
C
R
L
L
E
T
H
N
---
Q
V
I
I
--
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
-
W
V
D
S
V
E
----
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
69.23
31%
-10
- C3 -
-
4ZKI
-
?
A:
[38-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
---
I
E
A
L
---
S
D
G
A
W
-
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
----
L
K
K
D
------
N
P
A
K
Y
Y
T
--
I
K
R
E
F
T
K
RD
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
-
G
-
G
V
V
T
C
R
L
L
E
T
H
N
---
Q
V
I
I
--
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
-
W
V
D
S
V
E
----
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
69.04
29%
-114
- C3 -
-
4BIY
1
CPXA_ECOLI
A:
[83-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
---
T
A
L
L
---
R
R
R
S
G
-
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
---
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
G
-
P
W
P
L
Y
G
-------
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-----
H
-
T
-
K
I
E
-
V
G
F
A
V
D
K
D
G
I
-----
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.39
29%
-91
- C3 -
-
4BIV
2
CPXA_ECOLI
A:
[83-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
---
T
A
L
L
---
R
R
R
S
G
-
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
---
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
G
-
P
W
P
L
Y
G
-------
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-----
H
-
T
-
K
I
E
-
V
G
F
A
V
D
K
D
G
I
-----
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
68.10
29%
10
- C3 -
-
5C93
1
?
A:
[11-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
---
I
E
A
L
---
S
D
G
A
W
K
D
-
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
---
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
NPA
K
Y
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
-------
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
-
G
G
V
V
T
-
C
R
L
L
E
-----
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
-----
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.81
29%
-98
- C3 -
-
4BIU
-
CPXA_ECOLI
A:
[83-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
---
T
A
L
L
---
R
R
R
S
G
-
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
---
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
-----
K
S
L
T
V
N
F
P
P
G
-
P
W
P
L
Y
G
-------
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-----
H
-
T
-
K
I
E
-
V
G
F
A
V
D
K
D
G
I
-----
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
----------
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
67.21
29%
14
* C3 *
-
4U7O
1
?
A:
[33-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
---
I
E
A
L
---
S
D
G
A
W
-
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
---
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
NPA
K
Y
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
-------
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
-
G
G
V
V
T
-
C
R
L
L
E
-----
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
-----
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
66.95
32%
36
- C3 -
-
4JAV
1
?
B:
[5-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
E
------------------
S
----------------
K
E
L
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
---
L
G
E
L
D
-
L
-
S
T
L
-
K
E
-
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
---
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
-------
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
-
K
---
Y
-
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
---
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
-----
S
E
V
G
K
G
S
R
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.78
32%
31
- C3 -
-
4JAV
1
?
A:
[3-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----
V
T
--
E
------------------
S
----------------
K
E
L
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
---
L
G
E
L
D
-
L
-
S
T
L
-
K
E
-
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
---
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
-------
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
-
K
---
Y
-
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
---
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
-----
S
E
V
G
K
G
S
R
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
65.60
32%
25
- C3 -
-
4JAU
1
?
A:
[7-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----------------
K
E
L
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
---
A
E
M
I
Y
N
S
L
G
E
L
D
-
L
-
S
T
L
-
K
E
-
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
---
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
-------
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
-
K
---
Y
-
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
---
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
-----
S
E
V
G
K
G
S
R
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
65.31
32%
32
- C3 -
-
3DGE
1
?
B:
[14-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
AET
I
Y
N
S
---
L
G
E
L
D
-
L
-
S
T
L
-
K
E
-
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
---
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
-------
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
-
K
---
Y
-
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
---
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
-----
S
E
V
G
K
G
S
R
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
65.01
32%
38
- C3 -
-
4JAS
1
?
A:
[13-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
---
A
E
M
I
Y
N
S
L
G
E
L
D
-
L
-
S
T
L
-
K
E
-
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
---
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
-------
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
-
K
---
Y
-
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
---
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
-----
S
E
V
G
K
G
S
R
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.90
32%
37
- C3 -
-
3DGE
2
?
A:
[14-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
---
L
G
E
L
D
-
L
-
S
T
L
-
K
E
-
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
---
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
-------
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
-
K
---
Y
-
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
---
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
-----
S
E
V
G
K
G
S
R
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.68
32%
29
- C3 -
-
2C2A
1
?
A:
[1-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
-----
V
T
--
E
------------------
S
----------------
K
E
L
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
---
L
G
E
L
D
-
L
-
S
T
L
-
K
E
-
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
---
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
-------
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
-
K
---
Y
-
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
---
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
-----
S
E
V
G
K
G
S
R
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------