@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKL8: (2017-10-27 )
MNFDRNTPIAFLGIGLMGNRMASHLIQAGFQVAVWNRTASACEELIDIGAHALDLSNIGQYPLILTCLADDKAVQAVFDQIQTNLKAGQVIVDFSSLSVAATKALAQAAALQDVIWIDSPVSGGTAGAEQGTLVIFAGGDAQTIEALSPVYNVLSQRVTRMGDTGTGQATKICNQLIVAANSALIAEAVALADRAGVDTTLLAPALAGGFADSKPFQILAPRMATHTFEPVQWKVQTLSKDLNNAVTLANNVNLDIPVAQKALLQLQTHQKNSFAEKDLATMIQVVEQ
Atome Classification :
(20 SA)
.........10........20........30.--......-.40......-..50--.....--.--.--.60-........70......-.---.---80--.........90........100.......110.......120.......130.......140.......150.......160-.-......170.......180.......190.......200.......210.....------.-.220-.-------.-......230.------.......240.......250.......260.......270.......280......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNFDRNT
P
I
A
F
L
G
I
G
L
M
G
N
R
M
A
S
H
L
I
QAG
F
Q
V
--
A
V
WNR
T
-
A
S
A
C
E
E
L
I
D
-IGAH--AL
D
L
S
--N--I--GQY-
P
L
I
L
T
CLAD
D
K
A
V
Q
A
V
-
F
---
D
---
Q
---
I
Q
T
NLKA
G
Q
V
I
V
DFSS
L
S
V
A
A
T
K
A
L
A
Q
A
A
A
LQ
D
V
I
W
IDSPVSGGTAGAEQ
G
T
L
V
I
F
AGGDA
Q
T
I
E
A
L
S
P
V
Y
N
V
L
S
Q
R
V
T
RMG-D-TGT
G
Q
A
T
K
I
C
N
Q
L
I
V
AA
N
S
A
L
I
A
E
A
V
A
L
ADRAGV
D
T
T
L
L
A
P
A
L
AGGFADSKP
F
Q
------
I
-LA-P-R-------M-ATHTFEP-
V
Q
------
W
K
V
Q
T
L
S
K
DLNN
A
V
T
LANNVNLD
I
P
V
A
Q
K
A
L
L
Q
L
Q
THQKNS
F
A
E
K
D
L
A
T
M
I
Q
V
VEQ
60
HHSearch
73.42
31%
-54
- C1 -
-
4DLL
-
?
B:
[32-315]
------
R
K
I
T
F
L
G
T
--
M
G
L
P
M
A
R
R
L
C
E
A
G
Y
A
L
--
Q
V
W
N
R
T
-
P
A
R
A
A
S
L
A
A
-
L
G
A
T
--
I
H
E
Q
A
R
A
A
--
A
--
R
D
A
-
D
I
V
V
S
M
L
E
N
G
A
V
V
Q
D
V
-
L
---
F
AQ-
G
---
V
A
A
A
M
K
P
G
S
L
F
L
D
M
A
S
I
T
P
R
E
A
R
D
H
A
A
R
L
G
A
L
G
I
A
H
L
D
T
P
V
S
G
G
T
V
G
A
E
Q
G
T
L
V
I
M
A
G
G
K
P
A
D
F
E
R
S
L
P
L
L
K
V
F
G
R
-
A
T
H
V
G
-
P
-
H
G
S
G
Q
L
T
K
L
A
N
Q
M
I
V
G
I
T
I
G
A
V
A
E
A
L
L
F
A
T
K
G
G
A
D
M
A
K
V
K
E
A
I
T
G
G
F
A
D
S
R
V
L
Q
------
L
-
H
G
-
Q
-
R
-------
M
-
V
E
R
D
F
A
P
-
R
-------
A
R
L
S
I
Q
L
K
D
M
R
N
A
L
A
T
A
Q
E
I
G
F
D
A
P
I
T
G
L
F
E
Q
L
Y
A
E
G
V
E
H
G
L
T
D
L
D
Q
S
G
L
F
V
E
L
A
S
59
HHSearch
72.98
31%
-46
- C1 -
-
4DLL
-
?
A:
[29-315]
---
P
Y
A
R
K
I
T
F
L
G
T
G
S
M
G
L
P
M
A
R
R
L
C
E
A
G
Y
A
L
--
Q
V
W
N
R
T
-
P
A
R
A
A
S
L
A
A
-
L
G
A
T
--
I
H
E
Q
A
R
A
A
--
A
--
R
D
A
-
D
I
V
V
S
M
L
E
N
G
A
V
V
Q
D
V
-
L
---
F
AQ-
G
---
V
A
A
A
M
K
P
G
S
L
F
L
D
M
A
S
I
T
P
R
E
A
R
D
H
A
A
R
L
G
A
L
G
I
A
H
L
D
T
P
V
S
G
G
T
V
G
A
E
Q
G
T
L
V
I
M
A
G
G
K
P
A
D
F
E
R
S
L
P
L
L
K
V
F
G
R
-
A
T
H
V
G
-
P
-
H
G
S
G
Q
L
T
K
L
A
N
Q
M
I
V
G
I
T
I
G
A
V
A
E
A
L
L
F
A
T
K
G
G
A
D
M
A
K
V
K
E
A
I
T
G
G
F
A
D
S
R
V
L
Q
------
L
-
H
G
-
Q
-
R
-------
M
-
V
E
R
D
F
A
P
-
R
-------
A
R
L
S
I
Q
L
K
D
M
R
N
A
L
A
T
A
Q
E
I
G
F
D
A
P
I
T
G
L
F
E
Q
L
Y
A
E
G
V
E
H
G
L
T
D
L
D
Q
S
G
L
F
V
E
L
A
S
58
HHSearch
71.05
24%
-62
- C1 -
-
3G0O
1
?
A:
[7-293]
-----
D
F
H
V
G
I
V
G
L
G
S
M
G
M
G
A
A
R
S
C
L
R
A
G
L
S
T
--
W
G
A
D
L
N
-
P
Q
A
C
A
N
L
L
A
-
E
G
A
C
G-
A
A
A
S
A
RE
F
--
A
--
G
V
V
-
D
A
L
V
I
L
V
V
N
A
A
Q
V
R
Q
V
-
L
---
F
D--
G
---
V
A
H
L
M
K
P
G
S
A
V
M
V
S
S
T
I
S
S
A
D
A
Q
E
I
A
A
A
L
T
A
L
N
L
N
M
L
D
A
P
V
S
G
G
A
V
K
A
A
Q
G
E
M
T
V
M
A
S
G
S
E
A
A
F
T
R
L
K
P
V
L
D
A
V
A
S
N
V
Y
R
I
S
D
T
-
P
G
A
G
S
T
V
K
I
I
H
Q
L
L
A
G
V
H
I
A
A
A
A
E
A
M
A
L
A
A
R
A
G
I
P
L
D
V
M
Y
D
V
V
T
H
A
A
G
N
S
W
M
F
E
------
N
-
R
M
-
Q
-
H
-------
V
-
V
D
G
D
Y
T
P
-
R
-------
S
A
V
D
I
F
V
K
D
L
G
L
V
A
D
T
A
K
A
L
R
F
P
L
P
L
A
S
T
A
L
N
M
F
T
S
A
S
N
A
G
Y
G
K
E
D
D
S
A
V
I
K
I
F
--
53
HHSearch
71.04
26%
-21
* C1 *
-
3PEF
2
?
C:
[1-287]
-----
S
Q
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
--
T
I
W
N
R
S
-
P
E
K
A
E
E
L
A
A
-
L
G
A
E
--
R
A
A
T
P
CE
V
--
V
--
E
S
C
-
P
V
T
F
A
M
L
A
D
P
A
A
A
E
E
V
-
C
---
F
---
G
KHG
V
L
E
G
I
G
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
-
D
-
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
A
G
A
M
A
N
P
M
F
A
------
L
-
K
G
-
G
-
L
-------
I
-
R
D
R
N
F
A
P
-
A
-------
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
S
A
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
R
20
PsiBlast_PDB
70.49
25%
-52
- C1 -
-
3Q3C
1
SERDH_PSEAE
A:
[5-294]
--------
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
--
N
V
F
D
L
V
-
Q
S
A
V
D
G
L
V
A
-
A
G
A
S
--
A
A
R
S
A
--
R
D
A
V
--
Q
G
A
-
D
V
V
I
S
M
L
P
A
S
Q
H
V
E
G
L
-
Y
LDD----
G
---
L
L
A
H
I
A
P
G
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
I
F
H
A
G
-
P
-
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
M
R
R
S
S
G
G
N
W
A
L
E
------
V
-
Y
N
-
P
-
W
-------
P
-
G
V
M
E
N
A
P
-
A
S
RDYSGG
F
M
A
Q
L
M
A
K
D
L
G
L
A
Q
E
A
A
Q
A
S
A
S
S
T
P
M
G
S
L
A
L
S
L
Y
R
L
L
L
K
Q
G
Y
A
E
R
D
F
S
V
V
Q
K
L
F
D
-
64
HHSearch
70.46
27%
-43
- C1 -
-
3OBB
2
SERDH_PSEAE
A:
[3-296]
-----
M
K
Q
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
--
N
V
F
D
L
V
-
Q
S
A
V
D
G
L
V
A
-
A
G
A
S
--
A
A
R
S
A
R
D
A
--
V
--
Q
G
A
-
D
V
V
I
S
M
L
P
A
S
Q
H
V
E
G
L
-
Y
LDD
D
---
G
---
L
L
A
H
I
A
P
-
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
I
F
H
A
G
-
P
-
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
M
R
R
S
S
G
G
N
W
A
L
E
------
V
-
Y
N
-
P
-
W
PGVMENA
P
-
A
S
R
D
Y
S
G
-
G
-------
F
M
A
Q
L
M
A
K
D
L
G
L
A
Q
E
A
A
Q
A
S
A
S
S
T
P
M
G
S
L
A
L
S
L
Y
R
L
L
L
K
Q
G
Y
A
E
R
D
F
S
V
V
Q
K
L
F
D
P
6
PsiBlast_PDB
70.11
29%
-12
- C1 -
-
1VPD
1
?
A:
[8-291]
--------
V
G
F
I
G
L
G
I
M
G
K
P
M
S
K
N
L
L
K
A
G
Y
S
L
--
V
V
S
D
R
N
-
P
E
A
I
A
D
V
I
A
-
A
G
A
E
--
T
A
S
T
A
--
K
--
A
I
A
E
Q
C
-
D
V
I
I
T
M
L
P
N
S
P
H
V
K
E
V
-
A
LGE
N
---
G
---
I
I
E
G
A
K
P
G
T
V
L
I
D
M
S
S
I
A
P
L
A
S
R
E
I
S
D
A
L
K
A
K
G
V
E
M
L
D
A
P
V
S
G
G
E
P
K
A
I
D
G
T
L
S
V
M
V
G
G
D
K
A
I
F
D
K
Y
Y
D
L
M
K
A
M
A
G
S
V
V
H
T
G
-
D
-
I
G
A
G
N
V
T
K
L
A
N
Q
V
I
V
A
L
N
I
A
A
M
S
E
A
L
T
L
A
T
K
A
G
V
N
P
D
L
V
Y
Q
A
I
R
G
G
L
A
G
S
T
V
L
D
------
A
-
K
A
-
P
-
M
-------
V
-
M
D
R
N
F
K
P
--
G
------
F
R
I
D
L
H
I
K
D
L
A
N
A
L
D
T
S
H
G
V
G
A
Q
L
P
L
T
A
A
V
M
E
M
M
Q
A
L
R
A
D
G
H
G
N
D
D
H
S
A
L
A
C
Y
Y
E
K
70
HHSearch
70.00
27%
-14
- C1 -
-
2CVZ
1
?
C:
[1-282]
-----
M
E
K
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
L
A
R
-
R
F
P
T
--
L
V
W
N
R
T
-
F
E
K
A
L
R
H
Q
E
E
F
G
S
E
--
A
-
V
P
L
E-
R
--
V
--
A
E
A
-
R
V
I
F
T
C
L
P
T
T
R
E
V
Y
E
V
-
A
---
E
---
A
---
L
Y
P
Y
L
R
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
F
L
A
-
Y
A
K
K
V
V
H
V
G
-
P
-
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
N
A
S
S
G
R
S
N
A
T
E
------
N
-
L
I
P
Q
-
R
-------
V
-
L
T
R
A
F
P
K
-
T
-------
F
A
L
G
L
L
V
K
D
L
G
I
A
M
G
V
L
D
G
E
K
A
P
S
P
L
L
R
L
A
R
E
V
Y
E
M
A
K
R
E
L
G
P
D
A
D
H
V
E
A
L
R
L
L
E
R
54
HHSearch
69.97
27%
-28
- C1 -
-
3PDU
4
?
D:
[1-287]
-----
M
T
T
Y
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
--
T
V
W
N
R
N
-
P
A
K
C
A
P
L
V
A
-
L
G
A
R
--
Q
A
S
S
P
AE
V
--
C
--
A
A
C
-
D
I
T
I
A
M
L
A
D
P
A
A
A
R
E
V
-
C
---
F
---
G
ANG
V
L
E
G
I
G
G
G
R
G
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
-
E
-
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
A
G
A
M
A
N
P
M
F
K
------
G
-
K
G
-
Q
-
M
-------
L
-
L
S
G
E
F
P
T
-
S
-------
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
E
L
G
D
R
L
G
Q
P
L
H
G
A
A
T
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
A
68
HHSearch
69.64
24%
-48
- C1 -
-
4GBJ
-
?
D:
[7-291]
-------
K
I
A
F
L
G
L
G
N
L
G
T
P
I
A
E
I
L
L
E
A
G
Y
E
L
--
V
V
W
N
R
T
-
A
S
K
A
E
P
L
T
K
-
L
G
A
T
--
V
V
E
N
A
ID
A
--
I
--
T
P
G
-
G
I
V
F
S
V
L
A
D
D
A
A
V
E
E
L
-
F
---
S
M--
E
---
L
V
E
K
L
G
K
D
G
V
H
V
S
M
S
T
I
S
P
E
T
S
R
Q
L
A
Q
V
H
E
W
Y
G
A
H
Y
V
G
A
P
I
F
A
R
P
E
A
V
R
A
K
V
G
N
I
C
L
S
G
N
A
G
A
K
E
R
I
K
P
I
V
E
N
F
V
K
G
V
F
D
F
G
D
D
-
P
G
A
A
N
V
I
K
L
A
G
N
F
M
I
A
C
S
L
E
M
M
G
E
A
F
T
M
A
E
K
N
G
I
S
R
Q
S
I
Y
E
M
L
T
S
T
L
F
A
A
P
I
F
Q
------
N
-
Y
G
-
K
-
L
-------
V
-
A
S
N
T
Y
E
P
V
A
-------
F
R
F
P
L
G
L
K
D
I
N
L
T
L
Q
T
A
S
D
V
N
A
P
M
P
F
A
D
I
I
R
N
R
F
I
S
G
L
A
K
G
R
E
N
L
D
W
G
A
L
A
L
G
A
S
D
62
HHSearch
69.37
26%
-21
- C1 -
-
2GF2
-
3HIDH_HUMAN
B:
[40-332]
------
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
--
I
I
Y
D
V
F
-
P
D
A
C
K
E
F
Q
D
-
A
G
E
Q
--
V
V
S
S
P
AD
V
--
A
--
E
K
A
-
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
-
Y
---
S
GAN
G
---
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
-
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
TYNPVP
G
-
V
M
-
D
-
G
-------
V
P
S
A
N
N
Y
Q
G
-
G
-------
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
E
15
PsiBlast_PDB
69.32
27%
-0
- C1 -
-
5JE8
2
?
A:
[7-295]
-----
M
K
K
I
G
F
I
G
L
G
N
M
G
L
P
M
S
K
N
L
V
K
S
G
Y
T
V
Y
G
V
D
L
N
K
E
-
A
E
A
S
F
E
K
-
E
-
G
G
I
I
--
G
L
S
I
S
--
K
--
L
--
A
E
T
C
D
V
V
F
T
S
L
P
S
P
R
A
V
E
A
V
-
Y
FGA
E
---
G
---
L
F
E
N
G
H
S
N
V
V
F
I
D
T
S
T
V
S
P
Q
L
N
K
Q
L
E
E
A
A
K
E
K
K
V
D
F
L
A
A
P
V
S
G
G
V
I
G
A
E
N
R
T
L
T
F
M
V
G
G
S
K
D
V
Y
E
K
T
E
S
I
M
G
V
L
G
A
N
I
F
H
V
S
-
E
Q
I
D
S
G
T
T
V
K
L
I
N
N
L
L
I
G
F
Y
T
A
G
V
S
E
A
L
T
L
A
K
K
N
N
M
D
L
D
K
M
F
D
I
L
N
V
S
Y
G
Q
S
R
I
Y
E
------
R
N
Y
K
-
S
-
F
-------
I
-
A
P
E
N
Y
E
P
--
G
------
F
T
V
N
L
L
K
K
D
L
G
F
A
V
D
L
A
K
E
S
E
L
H
L
P
V
S
E
M
L
L
N
V
Y
D
E
A
S
Q
A
G
Y
G
E
N
D
M
A
A
L
Y
K
K
V
S
E
71
HHSearch
69.03
29%
-32
- C- -
-
3CKY
-
HMGD_EUBBA
B:
[4-290]
-----
S
I
K
I
G
F
I
G
L
G
A
M
G
K
P
M
A
I
N
L
L
K
E
G
V
T
V
--
Y
A
F
D
L
M
-
E
A
N
V
A
A
V
V
A
-
Q
G
A
Q
--
A
C
E
N
N
QK
V
--
A
--
A
A
S
-
D
I
I
F
T
S
L
P
N
A
G
I
V
E
T
V
-
M
---
N
---
G
PGG
V
L
S
A
C
K
A
G
T
V
I
V
D
M
S
S
V
S
P
S
S
T
L
K
M
A
K
V
A
A
E
K
G
I
D
Y
V
D
A
P
V
S
G
G
T
K
G
A
E
A
G
T
L
T
I
M
V
G
A
S
E
A
V
F
E
K
I
Q
P
V
L
S
V
I
G
K
D
I
Y
H
V
G
-
D
-
T
G
A
G
D
A
V
K
I
V
N
N
L
L
L
G
C
N
M
A
S
L
A
E
A
L
V
L
G
V
K
C
G
L
K
P
E
T
M
Q
E
I
I
G
K
S
S
G
R
S
Y
A
M
E
------
A
-
K
M
-
E
-
K
F------
I
-
M
S
G
D
F
A
G
-
G
-------
F
A
M
D
L
Q
H
K
D
L
G
L
A
L
E
A
G
K
E
G
N
V
P
L
P
M
T
A
M
A
T
Q
I
F
E
G
G
R
A
M
G
L
G
R
E
D
M
S
A
V
I
K
V
W
E
-
55
HHSearch
68.95
26%
-12
- C1 -
-
3DOJ
-
GLYR1_ARATH
A:
[18-307]
--
G
S
H
M
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
--
T
V
W
N
R
T
-
L
S
K
C
D
E
L
V
E
-
H
G
A
S
--
V
C
E
S
P
A
E
V
--
I
--
K
K
C
-
K
Y
T
I
A
M
L
S
D
P
C
A
A
L
S
V
-
V
---
F
---
D
KGG
V
L
E
Q
I
C
E
G
K
G
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
N
E
A
I
T
G
K
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
S
F
Y
L
G
-
Q
-
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
L
D
L
G
A
M
T
N
P
M
F
K
------
G
-
K
G
-
P
-
S
-------
M
-
N
K
S
S
Y
P
P
-
A
-------
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
N
A
V
S
M
P
V
A
A
A
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
F
10
PsiBlast_PDB
68.82
26%
-27
- C1 -
-
3PDU
3
?
A:
[2-286]
------
T
T
Y
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
--
T
V
W
N
R
N
-
P
A
K
C
A
P
L
V
A
-
L
G
A
R
Q
A
S
S
P
A
E
--
V
--
C
--
A
A
C
-
D
I
T
I
A
M
L
A
D
P
A
A
A
R
E
V
-
C
FGA
N
---
G
---
V
L
E
G
I
G
G
G
R
G
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
-
E
-
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
A
G
A
M
A
N
P
M
F
K
------
G
-
K
G
-
Q
-
M
-------
L
-
L
S
G
E
F
-
P
-
T
S
------
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
E
L
G
D
R
L
G
Q
P
L
H
G
A
A
T
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
-
69
HHSearch
68.64
24%
-43
- C1 -
-
4GBJ
-
?
C:
[6-291]
------
E
K
I
A
F
L
G
L
G
N
L
G
T
P
I
A
E
I
L
L
E
A
G
Y
E
L
--
V
V
W
N
R
T
-
A
S
K
A
E
P
L
T
K
-
L
G
A
T
--
V
V
E
N
A
ID
A
--
I
--
T
P
G
-
G
I
V
F
S
V
L
A
D
D
A
A
V
E
E
L
-
F
---
S
M
--
E
---
L
V
E
K
L
G
K
D
G
V
H
V
S
M
S
T
I
S
P
E
T
S
R
Q
L
A
Q
V
H
E
W
Y
G
A
H
Y
V
G
A
P
I
F
A
R
P
E
A
V
R
A
K
V
G
N
I
C
L
S
G
N
A
G
A
K
E
R
I
K
P
I
V
E
N
F
V
K
G
V
F
D
F
G
D
D
-
P
G
A
A
N
V
I
K
L
A
G
N
F
M
I
A
C
S
L
E
M
M
G
E
A
F
T
M
A
E
K
N
G
I
S
R
Q
S
I
Y
E
M
L
T
S
T
L
F
A
A
P
I
F
Q
------
N
-
Y
G
-
K
-
L
-------
V
-
A
S
N
T
Y
E
P
V
A
-------
F
R
F
P
L
G
L
K
D
I
N
L
T
L
Q
T
A
S
D
V
N
A
P
M
P
F
A
D
I
I
R
N
R
F
I
S
G
L
A
K
G
R
E
N
L
D
W
G
A
L
A
L
G
A
S
D
57
HHSearch
68.63
25%
-28
- C1 -
-
2UYY
-
GLYR1_HUMAN
C:
[26-316]
-
I
T
P
T
D
K
K
I
G
F
L
G
L
G
L
M
G
S
G
I
V
S
N
L
L
K
M
G
H
T
V
--
T
V
W
N
R
T
-
A
E
K
C
D
L
F
I
Q
-
E
G
A
R
--
L
G
R
T
P
AE
V
--
V
--
S
T
C
-
D
I
T
F
A
C
V
S
D
P
K
A
A
K
D
L
-
V
---
L
---
G
PSG
V
L
Q
G
I
R
P
G
K
C
Y
V
D
M
S
T
V
D
A
D
T
V
T
E
L
A
Q
V
I
V
S
R
G
G
R
F
L
E
A
P
V
S
G
N
Q
Q
L
S
N
D
G
M
L
V
I
L
A
A
G
D
R
G
L
Y
E
D
C
S
S
C
F
Q
A
M
G
K
T
S
F
F
L
G
-
E
-
V
G
N
A
A
K
M
M
L
I
V
N
M
V
Q
G
S
F
M
A
T
I
A
E
G
L
T
L
A
Q
V
T
G
Q
S
Q
Q
T
L
L
D
I
L
N
Q
G
Q
L
A
S
I
F
L
D
------
Q
-
K
C
-
Q
-
N
-------
I
-
L
Q
G
N
F
K
P
-
D
-------
F
Y
L
K
Y
I
Q
K
D
L
R
L
A
I
A
L
G
D
A
V
N
H
P
T
P
M
A
A
A
A
N
E
V
Y
K
R
A
K
A
L
D
Q
S
D
N
D
M
S
A
V
Y
R
A
Y
I
H
7
PsiBlast_PDB
68.61
25%
-16
- C1 -
-
3PEF
6
?
A:
[4-287]
--------
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
--
T
I
W
N
R
S
-
P
E
K
A
E
E
L
A
A
-
L
G
A
E
R
A
A
T
P
C
E
--
V
--
V
--
E
S
C
-
P
V
T
F
A
M
L
A
D
P
A
A
A
E
E
V
C
F
---
G
---
K
HG-
V
L
E
G
I
G
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
-
D
-
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
A
G
A
M
A
N
P
M
F
A
------
L
-
K
G
-
G
-
L
-------
I
-
R
D
R
N
F
A
P
-
A
-------
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
S
A
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
R
11
PsiBlast_PDB
68.37
27%
-24
- C1 -
-
2CVZ
1
?
A:
[4-282]
--------
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
L
A
R
R
-
F
P
T
--
L
V
W
N
R
T
F
E
K
A
L
R
H
Q
E
E
-
F
G
S
E
--
A
V
P
L
E
--
R
--
V
--
A
E
A
-
R
V
I
F
T
C
L
P
T
T
R
E
V
Y
E
V
-
A
---
E
---
A
---
L
Y
P
Y
L
R
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
-
F
L
A
Y
A
K
K
V
V
H
V
G
-
P
-
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
N
A
S
S
G
R
S
N
A
T
E
------
N
-
L
I
-
P
Q
R
-------
V
-
L
T
R
A
F
-
P
-
K
T
------
F
A
L
G
L
L
V
K
D
L
G
I
A
M
G
V
L
D
G
E
K
A
P
S
P
L
L
R
L
A
R
E
V
Y
E
M
A
K
R
E
L
G
P
D
A
D
H
V
E
A
L
R
L
L
E
R
9
PsiBlast_PDB
68.27
28%
-21
- C1 -
-
1WP4
1
?
A:
[4-282]
--------
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
L
A
R
R
-
F
P
T
--
L
V
W
N
R
T
F
E
K
A
L
R
H
Q
E
E
-
F
G
S
E
--
A
V
P
L
E
--
R
--
V
--
A
E
A
-
R
V
I
F
T
C
L
P
T
T
R
E
V
Y
E
V
-
A
---
E
---
A
---
L
Y
P
Y
L
R
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
-
F
L
A
Y
A
K
K
V
V
H
V
G
-
P
-
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
N
A
S
S
G
R
S
N
A
T
E
------
N
-
L
I
-
P
Q
R
-------
V
-
L
T
R
A
F
-
P
-
K
T
------
F
A
L
G
L
L
V
K
D
L
G
I
A
M
G
V
L
D
G
E
K
A
P
S
P
L
L
R
L
A
R
E
V
Y
E
M
A
K
R
E
L
G
P
D
A
D
H
V
E
A
L
R
L
L
E
R