@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKM3: (2017-10-27 )
MEFIQANANWLYLVGAILFILTLRGLSGPKTAIQGNRYGMIAMAIAVVTTFFVANNPVIWMIGGAMVLGAIVGIARARTVPMTQMPETVALMHSLVGLAAVLIAVAAILHNNQLTALFAQNEAALTAAGVQHAHMSKVHLFELFVGCFVGAITFTASVFAYGKLAAKKWAKTISGAWVKPVQALIFVAMLACGFYFFTTGNMTAFWAMTALALAFGWVWIAPVGGGDMPVVVSLLNSFSGWAAAGIGFTLENNMLIVAGSLVGSSGAILSYIMCKAMNRSIINVLFGGAMGGAAVSTAAKGEQVQRNYRSGSADDAGFLMSNADSVVIVPGYGMAQGRAQNAVKELCEILKEQGVRVRFAIHPVAGRMPGHMNVLLAEADVAYEDILEMDEINSDFPATDVVLVIGANDVVNPAAKDDPGSPIYGMPILEAHKARTIMVIKRSMATGYAGLDNDLFYNEKTMMIFGDAKKVVEDMTKAINGTGH
Atome Classification :
(37 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
F
I
QANAN
W
L
Y
L
V
G
A
I
L
F
I
L
T
LRGLSGPKTAIQGNR
Y
G
M
I
A
M
A
I
A
V
V
T
T
F
FVANN
P
V
I
W
M
IG
G
A
M
V
L
G
A
I
V
G
IARARTVPMTQM
P
E
T
V
A
L
M
H
S
L
V
G
L
A
A
V
L
I
A
V
A
A
I
L
HNN
Q
L
T
A
L
F
AQNE
A
A
L
T
A
AGVQ
H
A
H
M
S
K
V
H
L
F
E
L
F
V
G
C
F
V
G
A
I
T
F
T
A
S
V
F
A
Y
G
K
L
A
A
K
K
W
A
K
T
ISG
A
W
V
K
P
V
Q
A
L
I
F
V
A
M
L
A
C
G
F
Y
F
FTTGN
M
T
A
F
W
A
M
T
A
L
A
L
A
FG
W
V
W
I
A
PVGGG
D
M
P
V
V
V
S
L
L
N
SFSGWAAA
G
I
G
F
T
LEN
N
M
L
I
V
A
GSLVGS
S
G
A
I
L
S
Y
I
M
C
K
A
M
N
R
S
I
I
N
V
L
FGGAMGG
A
A
VSTAAK
G
E
Q
V
Q
R
N
YRSGSADDA
G
F
L
MSNAD
S
V
V
I
VPGYGMAQ
G
R
A
Q
N
A
V
K
E
L
C
E
I
L
K
EQG
V
R
V
R
F
A
I
H
P
V
AGRMPGH
M
N
V
L
L
AEA
D
V
A
Y
E
D
I
L
E
M
D
EINSDFPAT
D
V
V
L
V
IGANDVVNPAAKDDPGSPIYGMPILEAHK
A
R
T
I
M
V
I
K
RSMATGYAGLDNDLFYNE
K
T
M
M
I
FG
D
A
K
K
V
V
E
D
M
T
K
AINGTGH
1
PsiBlast_PDB
79.30
40%
-158
- C8 -
-
4O9U
1
?
B:
[1-448]
M
D
L
I
Q
A
A
----
Y
F
V
V
A
I
L
F
I
V
G
L
K
R
M
A
H
P
T
T
A
K
S
G
I
V
W
A
G
W
G
M
V
L
A
V
L
A
T
F
F
W
P
G
M
G
N
F
A
L
I
L
L
A
L
L
L
G
S
V
V
A
W
W
A
A
V
R
V
A
M
T
D
M
P
Q
M
V
A
I
Y
N
G
M
G
G
G
A
A
A
T
I
A
A
V
E
L
L
K
G
-------
A
F
E
N
T
G
L
M
A
L
A
I
--------------
L
G
G
L
I
G
S
V
A
F
T
G
S
L
I
A
F
A
K
L
Q
G
I
M
K
S
R
P
I
L
F
P
G
Q
K
A
V
N
A
L
V
L
A
L
T
V
V
I
G
L
S
L
L
W
N
D
A
T
A
S
I
V
L
F
F
L
L
A
L
L
F
G
V
L
M
T
L
P
I
G
G
G
D
M
P
V
A
I
S
F
Y
N
A
F
T
G
M
A
V
G
F
E
G
F
A
V
G
N
P
A
L
M
V
A
G
T
L
V
G
A
A
G
T
L
L
T
V
L
M
A
R
A
M
N
R
S
V
W
S
V
L
V
G
G
----------------
K
G
S
L
K
P
I
D
V
E
D
A
A
V
M
L
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
-
R
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
----
15
PsiBlast_PDB
65.22
60%
-139
- C8 -
-
1PNQ
1
PNTB_RHORT
A:
[3-180]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
E
G
R
H
M
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
5
PsiBlast_PDB
65.15
59%
-153
- C8 -
-
1U28
1
C:
[30-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
49
HHSearch
64.95
61%
-143
- C8 -
-
1PNO
2
B:
[5-180]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
R
H
M
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
22
PsiBlast_CBE
64.81
60%
-143
- C8 -
-
1PNO
2
B:
[4-180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
G
R
H
M
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
24
PsiBlast_CBE
64.75
62%
-154
- C8 -
-
1XLT
1
PNTB_RHORT
F:
[2-174]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
8
PsiBlast_PDB
64.50
59%
-148
- C8 -
-
2FR8
1
C:
[30-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
10
PsiBlast_PDB
64.48
59%
-140
- C8 -
-
2FSV
1
C:
[30-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
W
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
21
PsiBlast_CBE
64.42
60%
-143
- C8 -
-
1PNQ
2
B:
[4-180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
G
R
H
M
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
4
PsiBlast_PDB
64.29
59%
-146
- C8 -
-
1NM5
1
C:
[30-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
48
HHSearch
64.04
60%
-140
- C8 -
-
1U2G
2
C:
[30-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
12
PsiBlast_PDB
63.85
62%
-146
- C8 -
-
2OO5
2
C:
[3-174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
7
PsiBlast_PDB
63.83
59%
-140
- C8 -
-
1U2G
2
C:
[30-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
23
PsiBlast_CBE
63.80
62%
-143
- C8 -
-
1XLT
2
I:
[2-174]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
14
PsiBlast_PDB
63.62
60%
-137
- C8 -
-
1PNO
1
PNTB_RHORT
A:
[3-180]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
E
G
R
H
M
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
66
Fugue
63.49
50%
-142
- C8 -
-
1D4O
1
A:
[5-181]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
S
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
E
S
--
51
HHSearch
63.49
50%
-142
* C8 *
-
1D4O
1
A:
[5-181]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
S
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
E
S
--
11
PsiBlast_PDB
63.49
62%
-148
- C8 -
-
1PTJ
1
C:
[3-174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
50
HHSearch
63.25
62%
-143
- C8 -
-
1XLT
2
PNTB_RHORT
C:
[2-174]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
16
PsiBlast_PDB
63.22
62%
-143
- C8 -
-
1XLT
2
PNTB_RHORT
C:
[2-174]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
30
PsiBlast_CBE
62.77
53%
-147
- C8 -
-
4J16
3
?
C:
[9-183]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
L
K
P
I
D
V
E
D
A
A
V
M
L
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
-
R
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
----
6
PsiBlast_PDB
62.66
59%
-140
- C8 -
-
1U2D
2
C:
[30-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
9
PsiBlast_PDB
62.20
59%
-140
- C8 -
-
2FRD
2
C:
[30-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
3
PsiBlast_PDB
61.45
59%
-150
- C8 -
-
1HZZ
1
C:
[30-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
13
PsiBlast_PDB
61.21
62%
-143
- C8 -
-
2OOR
1
C:
[3-173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
-----
20
PsiBlast_PDB
61.08
50%
-138
- C8 -
-
1U31
2
NNTM_HUMAN
A:
[23-195]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
-----------
18
PsiBlast_PDB
60.60
50%
-136
- C8 -
-
1DJL
2
NNTM_HUMAN
A:
[23-195]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
-----------
26
PsiBlast_CBE
59.10
50%
-142
- C8 -
-
1PT9
1
B:
[23-195]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
-----------
27
PsiBlast_CBE
58.72
50%
-141
- C8 -
-
1DJL
2
B:
[23-195]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
-----------
25
PsiBlast_CBE
58.66
50%
-142
- C8 -
-
1U31
2
B:
[23-195]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
-----------
19
PsiBlast_PDB
58.48
50%
-137
- C8 -
-
1PT9
1
NNTM_HUMAN
A:
[23-195]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
-----------
31
PsiBlast_CBE
57.58
56%
-142
- C8 -
-
1D4O
1
A:
[13-172]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
S
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
-----------
52
HHSearch
57.09
60%
-130
- C8 -
-
2BRU
2
C:
[20-186]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
E
T
A
E
L
L
K
N
S
H
S
V
I
I
T
P
G
Y
G
M
A
V
A
Q
A
Q
Y
P
V
A
E
I
T
E
K
L
R
A
R
G
I
N
V
R
F
G
I
H
P
V
A
G
R
L
P
G
H
M
N
V
L
L
A
E
A
K
V
P
Y
D
I
V
L
E
M
D
E
I
N
D
D
F
A
D
T
D
T
V
L
V
I
G
A
N
D
T
V
N
P
A
A
Q
D
D
P
K
S
P
I
A
G
M
P
V
L
E
V
W
K
A
Q
N
V
I
V
F
K
R
S
M
N
T
G
Y
A
G
V
Q
N
P
L
F
F
K
E
N
T
H
M
L
F
G
D
A
K
A
S
V
D
A
I
L
K
A
L
-----
17
PsiBlast_PDB
57.09
60%
-130
- C8 -
-
2BRU
2
C:
[20-186]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
E
T
A
E
L
L
K
N
S
H
S
V
I
I
T
P
G
Y
G
M
A
V
A
Q
A
Q
Y
P
V
A
E
I
T
E
K
L
R
A
R
G
I
N
V
R
F
G
I
H
P
V
A
G
R
L
P
G
H
M
N
V
L
L
A
E
A
K
V
P
Y
D
I
V
L
E
M
D
E
I
N
D
D
F
A
D
T
D
T
V
L
V
I
G
A
N
D
T
V
N
P
A
A
Q
D
D
P
K
S
P
I
A
G
M
P
V
L
E
V
W
K
A
Q
N
V
I
V
F
K
R
S
M
N
T
G
Y
A
G
V
Q
N
P
L
F
F
K
E
N
T
H
M
L
F
G
D
A
K
A
S
V
D
A
I
L
K
A
L
-----
67
Fugue
56.45
62%
-133
- C8 -
-
1E3T
1
A:
[29-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
47
HHSearch
56.03
60%
-133
- C8 -
-
1E3T
1
A:
[29-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----
2
PsiBlast_PDB
55.89
59%
-133
- C8 -
-
1E3T
1
A:
[29-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
K
A
G
S
A
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
----