@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKP5: (2017-10-27 )
MQIFYDKDCDLSIIQSKKVAIIGYGSQGHAHALNLKDSGVDVTVGLRAGSASWKKAENAGLKVAEVPAAVKQADLVMILTPDEFQSQLYRDVIEPNIKEGATLAFAHGFSVLYNQVVPRKDLDVIMVAPKAPGHTVRSEFQRGSGVPDLIAIHQDASGNARNVALSYASGVGGGRTGIIETSFREETETDLFGEQAVLCGGAVELVKMGFETLVEAGYAPEMAYFECLHELKLIVDLMFEGGIADMNYSVSNNAEYGEYVTGPEVINEQSREAMRNALKRIQSGEYAKMFIQEGALNYPSMTARRRQNAAHGIEQTGAKLRAMMPWIQANKIVDKEKN
Atome Classification :
(25 SA)
.........10........20........30.......------.40....---....-----50-.........60.-----.......70.........80.......-.-90........100.......110......---.120.......130.......140.-----......150.......160.......170....-...180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320...-....330......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Q
I
F
YDKDC
D
L
S
I
I
QSK
K
V
A
I
I
G
YGSQGH
A
H
A
LNLKDS------GV
D
V
T
V
G
---
L
RAG-----S--ASWKKAENAG
L
K
-----
V
AEVPAAV-KQA
D
L
V
M
I
LT
P
D
E
F
Q
S
Q
L
-
Y
-
R
D
V
IEPNIKE
G
A
T
L
A
F
A
H
G
F
S
V
L
Y
N
QVVP---RKDL
D
V
I
M
VAPKAPG
H
T
V
R
S
E
F
QRG-----SGVP
D
L
I
A
I
HQDASGNA
R
N
V
A
L
S
Y
ASGVGGGRT-
G
I
I
ETSFREETETDLFGEQ
A
V
LCG
G
A
V
E
L
V
K
M
G
F
E
T
L
V
EAGYA
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
FEGGIAD
M
N
Y
SVSNNAEYGEYVT
G
P
E
V
I
N
E
Q
S
R
E
A
M
R
N
A
L
K
R
IQS
G
E
Y
A
K
M
F
I
Q
EGALNYP
S
M
T
A
R
R
R
Q
N
A
AH
G
I
E
Q
T
G
A
K
L
R
A
M
M
P
-
W
I
Q
ANKIVDKEKN
50
HHSearch
91.84
84%
-113
- C2 -
-
4XIY
1
ILVC_AZOVD
D:
[1-328]
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
---
L
R
A
G
-----
S
--
A
S
V
A
K
A
E
A
H
G
L
T
-----
V
K
S
V
K
D
A
V
-
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
-
Y
-
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
V
V
P
---
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
R
T
-
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
-
W
I
A
----------
21
PsiBlast_CBE
91.58
83%
-113
- C2 -
-
4XIY
1
ILVC_AZOVD
D:
[1-328]
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
---
L
R
A
G
-----
S
--
A
S
V
A
K
A
E
A
H
G
L
T
-----
V
K
S
V
K
D
A
V
-
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
-
Y
-
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
V
V
P
---
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
R
T
-
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
-
W
I
A
----------
22
PsiBlast_CBE
91.37
83%
-117
- C2 -
-
4XIY
2
ILVC_AZOVD
C:
[1-328]
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
---
L
R
A
G
-----
S
--
A
S
V
A
K
A
E
A
H
G
L
T
-----
V
K
S
V
K
D
A
V
-
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
-
Y
-
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
V
V
P
---
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
R
T
-
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
-
W
I
A
----------
48
HHSearch
91.20
84%
-108
- C2 -
-
1NP3
-
ILVC_PSEAE
A:
[1-327]
M
R
V
F
Y
D
K
D
C
D
L
S
I
I
Q
G
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
T
V
G
---
L
R
S
G
-----
S
--
A
T
V
A
K
A
E
A
H
G
L
K
-----
V
A
D
V
K
T
A
V
-
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
-
Y
-
K
E
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
V
V
P
---
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
K
G
-----
G
G
I
P
D
L
I
A
I
Y
Q
D
A
S
G
N
A
K
N
V
A
L
S
Y
A
C
G
V
G
G
G
R
T
-
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
A
E
S
R
A
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
-
W
I
-----------
38
Fugue
90.95
83%
-108
- C2 -
-
1NP3
-
ILVC_PSEAE
A:
[1-327]
M
R
V
F
Y
D
K
D
C
D
L
S
I
I
Q
G
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
T
V
G
---
L
R
S
G
-----
S
--
A
T
V
A
K
A
E
A
H
G
L
K
-----
V
A
D
V
K
T
A
V
-
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
-
Y
-
K
E
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
V
V
P
---
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
K
G
-----
G
G
I
P
D
L
I
A
I
Y
Q
D
A
S
G
N
A
K
N
V
A
L
S
Y
A
C
G
V
G
G
G
R
T
-
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
A
E
S
R
A
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
-
W
I
-----------
1
PsiBlast_PDB
90.84
83%
-108
- C2 -
-
1NP3
-
ILVC_PSEAE
A:
[1-327]
M
R
V
F
Y
D
K
D
C
D
L
S
I
I
Q
G
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
T
V
G
---
L
R
S
G
-----
S
--
A
T
V
A
K
A
E
A
H
G
L
K
-----
V
A
D
V
K
T
A
V
-
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
-
Y
-
K
E
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
V
V
P
---
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
K
G
-----
G
G
I
P
D
L
I
A
I
Y
Q
D
A
S
G
N
A
K
N
V
A
L
S
Y
A
C
G
V
G
G
G
R
T
-
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
A
E
S
R
A
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
-
W
I
-----------
23
PsiBlast_CBE
89.61
83%
-108
- C2 -
-
4XIY
3
ILVC_AZOVD
B:
[1-328]
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
---
L
R
A
G
-----
S
--
A
S
V
A
K
A
E
A
H
G
L
T
-----
V
K
S
V
K
D
A
V
-
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
-
Y
-
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
V
V
P
---
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
R
T
-
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
-
W
I
A
----------
25
PsiBlast_CBE
89.52
59%
-113
- C2 -
-
4KQX
5
ILVC_SLAES
B:
[14-343]
--
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
---
L
R
E
G
-----
D
--
S
D
W
K
T
A
E
E
A
G
L
K
-----
V
T
D
M
D
T
A
A
-
E
E
A
D
V
I
M
V
L
V
P
D
E
V
Q
P
K
V
-
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
I
V
P
---
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
-
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
-
W
I
K
K
E
D
L
------
2
PsiBlast_PDB
88.47
60%
-115
- C2 -
-
4KQW
5
ILVC_SLAES
A:
[14-338]
--
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
---
L
R
E
G
-----
S
--
S
S
W
K
T
A
E
E
A
G
L
K
-----
V
T
D
M
D
T
A
A
-
E
E
A
D
V
I
M
V
L
V
P
D
E
I
Q
P
K
V
-
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
I
V
P
---
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
-
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
-
W
I
-----------
58
HHSearch
83.23
59%
-112
- C2 -
-
4KQX
5
ILVC_SLAES
B:
[13-344]
-
T
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
---
L
R
E
G
-----
D
--
S
D
W
K
T
A
E
E
A
G
L
K
-----
V
T
D
M
D
T
A
A
-
E
E
A
D
V
I
M
V
L
V
P
D
E
V
Q
P
K
V
-
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
I
V
P
---
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
-
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
-
W
I
K
K
E
D
L
E
-----
4
PsiBlast_PDB
82.67
56%
-112
- C2 -
-
4TSK
2
ILVC_ALIAD
A:
[3-334]
-
K
I
Y
Y
D
A
D
I
S
I
Q
P
L
A
D
K
R
I
A
V
I
G
Y
G
S
Q
G
H
A
H
A
Q
N
L
R
D
S
------
G
F
D
V
V
I
G
---
L
R
P
G
-----
S
---
S
W
A
K
A
E
A
D
G
F
R
-----
V
M
A
V
G
E
A
V
-
E
E
S
D
V
I
M
I
L
L
P
D
E
R
Q
P
A
V
-
Y
-
E
R
E
I
R
P
Y
L
T
A
G
K
A
L
A
F
A
H
G
F
N
I
H
F
S
Q
I
Q
P
---
P
K
D
V
D
V
F
M
V
A
P
K
G
P
G
H
L
V
R
R
V
Y
E
A
G
-----
G
G
V
P
A
L
I
A
V
H
Q
D
A
S
G
Q
A
K
D
L
A
L
A
Y
A
R
G
I
G
A
G
R
A
-
G
I
L
T
T
T
F
R
E
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
L
S
A
L
I
K
A
G
F
E
T
L
V
E
A
G
Y
Q
P
E
I
A
Y
F
E
C
L
H
E
M
K
L
I
V
D
L
I
Y
E
G
G
L
E
Y
M
R
Y
S
I
S
D
T
A
Q
W
G
D
F
T
S
G
P
R
I
I
N
E
E
T
K
K
E
M
R
R
I
L
A
D
I
Q
S
G
A
F
A
K
S
W
I
L
E
N
Q
A
N
R
P
M
F
N
A
I
N
R
R
E
L
E
H
P
I
E
V
V
G
R
K
L
R
S
M
M
P
-
F
I
K
A
K
R
P
G
D
----
55
HHSearch
81.84
55%
-112
- C2 -
-
4TSK
2
ILVC_ALIAD
A:
[2-334]
E
K
I
Y
Y
D
A
D
I
S
I
Q
P
L
A
D
K
R
I
A
V
I
G
Y
G
S
Q
G
H
A
H
A
Q
N
L
R
D
S
------
G
F
D
V
V
I
G
---
L
R
P
G
-----
S
--
S
W
-
A
K
A
E
A
D
G
F
R
-----
V
M
A
V
G
E
A
V
-
E
E
S
D
V
I
M
I
L
L
P
D
E
R
Q
P
A
V
-
Y
-
E
R
E
I
R
P
Y
L
T
A
G
K
A
L
A
F
A
H
G
F
N
I
H
F
S
Q
I
Q
P
---
P
K
D
V
D
V
F
M
V
A
P
K
G
P
G
H
L
V
R
R
V
Y
E
A
G
-----
G
G
V
P
A
L
I
A
V
H
Q
D
A
S
G
Q
A
K
D
L
A
L
A
Y
A
R
G
I
G
A
G
R
A
-
G
I
L
T
T
T
F
R
E
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
L
S
A
L
I
K
A
G
F
E
T
L
V
E
A
G
Y
Q
P
E
I
A
Y
F
E
C
L
H
E
M
K
L
I
V
D
L
I
Y
E
G
G
L
E
Y
M
R
Y
S
I
S
D
T
A
Q
W
G
D
F
T
S
G
P
R
I
I
N
E
E
T
K
K
E
M
R
R
I
L
A
D
I
Q
S
G
A
F
A
K
S
W
I
L
E
N
Q
A
N
R
P
M
F
N
A
I
N
R
R
E
L
E
H
P
I
E
V
V
G
R
K
L
R
S
M
M
P
-
F
I
K
A
K
R
P
G
D
----
57
HHSearch
81.76
60%
-113
- C2 -
-
4KQW
5
ILVC_SLAES
B:
[13-337]
-
T
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
---
L
R
E
G
-----
S
--
S
S
W
K
T
A
E
E
A
G
L
K
-----
V
T
D
M
D
T
A
A
-
E
E
A
D
V
I
M
V
L
V
P
D
E
I
Q
P
K
V
-
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
I
V
P
---
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
-
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
-
I
R
S
M
F
S
-
W
------------
24
PsiBlast_CBE
81.68
60%
-113
- C2 -
-
4KQW
5
ILVC_SLAES
B:
[14-337]
--
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
---
L
R
E
G
-----
S
--
S
S
W
K
T
A
E
E
A
G
L
K
-----
V
T
D
M
D
T
A
A
-
E
E
A
D
V
I
M
V
L
V
P
D
E
I
Q
P
K
V
-
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
I
V
P
---
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
-
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
-
I
R
S
M
F
S
-
W
------------
3
PsiBlast_PDB
81.56
59%
-110
- C2 -
-
4KQX
4
ILVC_SLAES
A:
[14-335]
--
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
---
L
R
E
G
-----
D
--
S
D
W
K
T
A
E
E
A
G
L
K
-----
V
T
D
M
D
T
A
A
-
E
E
A
D
V
I
M
V
L
V
P
D
E
V
Q
P
K
V
-
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
I
V
P
---
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
-
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
---------------
8
PsiBlast_PDB
79.05
46%
-118
- C2 -
-
4XDZ
8
ILVC_IGNAA
A:
[3-325]
-
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
---
L
E
R
Q
-----
G
--
D
S
W
R
R
A
I
D
D
G
F
K
-----
P
M
Y
T
K
D
A
V
-
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
-
W
-
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
I
E
P
---
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
R
A
-
G
V
I
E
S
T
F
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
K
L
I
V
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
R
G
M
P
T
V
F
K
E
L
S
E
L
E
G
S
T
I
E
T
V
G
R
K
L
R
E
M
M
---------------
28
PsiBlast_CBE
78.32
46%
-112
- C2 -
-
4XDZ
7
ILVC_IGNAA
B:
[3-325]
-
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
---
L
E
R
Q
-----
G
--
D
S
W
R
R
A
I
D
D
G
F
K
-----
P
M
Y
T
K
D
A
V
-
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
-
W
-
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
I
E
P
---
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
R
A
-
G
V
I
E
S
T
F
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
K
L
I
V
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
R
G
M
P
T
V
F
K
E
L
S
E
L
E
G
S
T
I
E
T
V
G
R
K
L
R
E
M
M
---------------
51
HHSearch
74.01
46%
-67
- C2 -
-
4XDZ
7
ILVC_IGNAA
B:
[2-330]
A
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
---
L
E
R
Q
-----
G
--
D
S
W
R
R
A
I
D
D
G
F
K
-----
P
M
Y
T
K
D
A
V
-
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
W
L
-
N
-
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
I
E
P
---
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
R
A
-
G
V
I
E
S
T
F
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
K
L
I
V
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
R
G
M
P
T
V
F
K
E
L
S
E
L
E
G
S
T
I
E
T
V
G
R
K
L
R
E
M
M
F
R
G
M
K
----------
5
PsiBlast_PDB
73.59
54%
-41
- C2 -
-
4YPO
-
ILVC_MYCTU
A:
[1-325]
--
M
F
Y
D
D
D
A
D
L
S
I
I
Q
G
R
K
V
G
V
I
G
Y
G
S
Q
G
H
A
H
S
L
S
L
R
D
S
------
G
V
Q
V
R
V
G
---
L
K
Q
G
-----
S
--
R
S
R
P
K
V
E
E
Q
G
L
D
-----
V
-
D
T
P
A
E
V
A
K
W
A
D
V
V
M
V
L
A
P
D
T
A
Q
A
E
I
-
F
-
A
G
D
I
E
P
N
L
K
P
G
D
A
L
F
F
G
H
G
L
N
V
H
F
G
L
I
K
P
---
P
A
D
V
A
V
A
M
V
A
P
K
G
P
G
H
L
V
R
R
Q
F
V
D
G
-----
K
G
V
P
C
L
V
A
V
E
Q
D
P
R
G
D
G
L
A
L
A
L
S
Y
A
K
A
I
G
G
T
R
A
-
G
V
I
K
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
T
V
L
C
G
G
T
E
E
L
V
K
A
G
F
E
V
M
V
E
A
G
Y
P
A
E
L
A
Y
F
E
V
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
L
A
R
M
Y
Y
S
V
S
D
T
A
E
F
G
G
Y
L
S
G
P
R
V
I
D
A
G
T
K
E
R
M
R
D
I
L
R
E
I
Q
D
G
S
F
V
H
K
L
V
A
D
V
E
G
G
N
K
Q
L
E
E
L
R
R
Q
N
A
E
H
P
I
E
V
V
G
K
K
L
R
D
L
M
S
-
W
V
-----------
56
HHSearch
72.26
54%
-27
- C2 -
-
4YPO
-
ILVC_MYCTU
A:
[1-325]
--
M
F
Y
D
D
D
A
D
L
S
I
I
Q
G
R
K
V
G
V
I
G
Y
G
S
Q
G
H
A
H
S
L
S
L
R
D
S
------
G
V
Q
V
R
V
G
---
L
K
Q
G
-----
S
--
R
S
R
P
K
V
E
E
Q
G
L
D
-----
V
D
T
P
A
E
V
A
-
K
W
A
D
V
V
M
V
L
A
P
D
T
A
Q
A
E
I
-
F
A
G
-
D
I
E
P
N
L
K
P
G
D
A
L
F
F
G
H
G
L
N
V
H
F
G
L
I
K
P
---
P
A
D
V
A
V
A
M
V
A
P
K
G
P
G
H
L
V
R
R
Q
F
V
D
G
-----
K
G
V
P
C
L
V
A
V
E
Q
D
P
R
G
D
G
L
A
L
A
L
S
Y
A
K
A
I
G
G
T
-
R
A
G
V
I
K
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
T
V
L
C
G
G
T
E
E
L
V
K
A
G
F
E
V
M
V
E
A
G
Y
P
A
E
L
A
Y
F
E
V
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
L
A
R
M
Y
Y
S
V
S
D
T
A
E
F
G
G
Y
L
S
G
P
R
V
I
D
A
G
T
K
E
R
M
R
D
I
L
R
E
I
Q
D
G
S
F
V
H
K
L
V
A
D
V
E
G
G
N
K
Q
L
E
E
L
R
R
Q
N
A
E
H
P
I
E
V
V
G
K
K
L
R
D
L
M
S
-
W
V
-----------
27
PsiBlast_CBE
67.21
46%
1
- C2 -
-
4XDY
5
ILVC_UNCAG
B:
[1-329]
M
E
I
L
H
D
E
D
V
D
D
S
I
L
R
D
K
T
I
A
V
M
G
Y
G
A
Q
G
D
A
Q
A
N
C
L
K
D
S
------
G
I
N
V
V
I
G
ETE
I
L
G
G
-----
N
KN
P
S
W
E
K
A
K
E
D
G
F
E
-----
V
L
P
I
D
K
A
A
-
E
K
G
D
V
V
H
I
L
L
P
D
E
V
Q
P
A
I
-
Y
-
E
N
Q
I
K
P
Q
L
K
A
G
K
A
L
C
F
S
H
G
F
N
I
C
F
K
R
I
V
P
---
P
E
D
V
D
V
I
M
V
A
P
K
A
P
G
T
E
E
R
K
A
Y
L
E
G
-----
F
G
V
P
G
L
V
A
V
K
Q
N
P
S
G
E
A
R
E
V
A
L
A
M
T
K
A
M
H
W
T
K
A
-
G
I
L
E
C
T
F
E
Q
E
T
Y
E
D
L
F
G
E
Q
C
V
L
C
G
G
L
V
E
L
M
R
N
G
F
E
V
L
V
E
A
G
Y
P
P
E
M
A
Y
F
E
C
V
H
E
M
K
L
I
V
D
L
V
W
Q
G
G
I
K
R
M
A
E
V
I
S
N
T
A
E
Y
G
M
W
A
V
G
H
Q
I
I
G
P
E
V
K
E
K
M
K
E
A
L
K
R
V
E
N
G
E
F
A
N
E
W
V
D
E
Y
K
R
G
I
P
F
L
K
A
S
R
E
K
M
G
E
H
Q
V
E
T
V
G
A
E
I
R
K
L
F
---------------
6
PsiBlast_PDB
66.15
46%
-0
- C2 -
-
4XDY
5
ILVC_UNCAG
A:
[1-329]
M
E
I
L
H
D
E
D
V
D
D
S
I
L
R
D
K
T
I
A
V
M
G
Y
G
A
Q
G
D
A
Q
A
N
C
L
K
D
S
------
G
I
N
V
V
I
G
E
T
E
I
L
G
G
-----
N
KN
P
S
W
E
K
A
K
E
D
G
F
E
-----
V
L
P
I
D
K
A
A
-
E
K
G
D
V
V
H
I
L
L
P
D
E
V
Q
P
A
I
-
Y
-
E
N
Q
I
K
P
Q
L
K
A
G
K
A
L
C
F
S
H
G
F
N
I
C
F
K
R
I
V
P
---
P
E
D
V
D
V
I
M
V
A
P
K
A
P
G
T
E
E
R
K
A
Y
L
E
G
-----
F
G
V
P
G
L
V
A
V
K
Q
N
P
S
G
E
A
R
E
V
A
L
A
M
T
K
A
M
H
W
T
K
A
-
G
I
L
E
C
T
F
E
Q
E
T
Y
E
D
L
F
G
E
Q
C
V
L
C
G
G
L
V
E
L
M
R
N
G
F
E
V
L
V
E
A
G
Y
P
P
E
M
A
Y
F
E
C
V
H
E
M
K
L
I
V
D
L
V
W
Q
G
G
I
K
R
M
A
E
V
I
S
N
T
A
E
Y
G
M
W
A
V
G
H
Q
I
I
G
P
E
V
K
E
K
M
K
E
A
L
K
R
V
E
N
G
E
F
A
N
E
W
V
D
E
Y
K
R
G
I
P
F
L
K
A
S
R
E
K
M
G
E
H
Q
V
E
T
V
G
A
E
I
R
K
L
F
---------------
54
HHSearch
63.63
46%
19
* C2 *
-
4XDY
5
ILVC_UNCAG
A:
[1-331]
M
E
I
L
H
D
E
D
V
D
D
S
I
L
R
D
K
T
I
A
V
M
G
Y
G
A
Q
G
D
A
Q
A
N
C
L
K
D
S
------
G
I
N
V
V
I
G
---
E
T
E
I
LGGNK
N
--
P
S
W
E
K
A
K
E
D
G
F
E
-----
V
L
P
I
D
K
A
A
-
E
K
G
D
V
V
H
I
L
L
P
D
E
V
Q
P
A
I
-
Y
E
N
-
Q
I
K
P
Q
L
K
A
G
K
A
L
C
F
S
H
G
F
N
I
C
F
K
R
I
V
P
---
P
E
D
V
D
V
I
M
V
A
P
K
A
P
G
T
E
E
R
K
A
Y
L
E
G
-----
F
G
V
P
G
L
V
A
V
K
Q
N
P
S
G
E
A
R
E
V
A
L
A
M
T
K
A
M
H
W
T
K
A
-
G
I
L
E
C
T
F
E
Q
E
T
Y
E
D
L
F
G
E
Q
C
V
L
C
G
G
L
V
E
L
M
R
N
G
F
E
V
L
V
E
A
G
Y
P
P
E
M
A
Y
F
E
C
V
H
E
M
K
L
I
V
D
L
V
W
Q
G
G
I
K
R
M
A
E
V
I
S
N
T
A
E
Y
G
M
W
A
V
G
H
Q
I
I
G
P
E
V
K
E
K
M
K
E
A
L
K
R
V
E
N
G
E
F
A
N
E
W
V
D
E
Y
K
R
G
I
P
F
L
K
A
S
R
E
K
M
G
E
H
Q
V
E
T
V
G
A
E
I
R
K
L
F
A
-
Q
------------
37
PsiBlast_CBE
45.98
33%
7
- C2 -
-
3FR8
2
ILV5_ORYSJ
B:
[55-278]
----------------
K
Q
I
G
V
I
G
W
G
S
Q
G
P
A
Q
A
Q
N
L
R
D
S
LAEAKS
D
I
V
V
K
I
G
---
L
R
K
G
-----
S
--
K
S
F
D
E
A
R
A
A
G
F
T
EESGT
L
G
D
I
W
E
T
V
-
S
G
S
D
L
V
L
L
L
I
S
D
A
A
Q
A
D
N
-
Y
-
E
K
I
F
S
-
H
M
K
P
N
S
I
L
G
L
S
H
G
F
L
L
G
H
L
Q
S
A
G
LDF
P
K
N
I
S
V
I
A
V
C
P
K
G
M
G
P
S
V
R
R
L
Y
V
Q
G
K
EIN
G
A
G
I
N
S
S
F
A
V
H
Q
D
V
D
G
R
A
T
D
V
A
L
G
W
S
V
A
L
G
S
P
F
T
---
F
A
T
T
L
E
Q
E
Y
K
S
D
I
F
G
E
R
G
I
L
L
G
A
V
H
G
I
V
E
A
L
F
R
R
Y
T
E
Q
G
M
D
E
E
M
A
Y
-------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
45.16
33%
10
- C2 -
-
3FR8
2
ILV5_ORYSJ
A:
[55-278]
----------------
K
Q
I
G
V
I
G
W
G
S
Q
G
P
A
Q
A
Q
N
L
R
D
S
L
A
E
A
KS
D
I
V
V
K
I
G
---
L
R
K
G
-----
S
--
K
S
F
D
E
A
R
A
A
G
F
T
EESGT
L
G
D
I
W
E
T
V
-
S
G
S
D
L
V
L
L
L
I
S
D
A
A
Q
A
D
N
-
Y
-
E
K
I
F
S
-
H
M
K
P
N
S
I
L
G
L
S
H
G
F
L
L
G
H
L
Q
S
A
G
LDF
P
K
N
I
S
V
I
A
V
C
P
K
G
M
G
P
S
V
R
R
L
Y
V
Q
G
K
E
ING
A
G
I
N
S
S
F
A
V
H
Q
D
V
D
G
R
A
T
D
V
A
L
G
W
S
V
A
L
G
S
P
F
T
---
F
A
T
T
L
E
Q
E
Y
K
S
D
I
F
G
E
R
G
I
L
L
G
A
V
H
G
I
V
E
A
L
F
R
R
Y
T
E
Q
G
M
D
E
E
M
A
Y
-------------------------------------------------------------------------------------------------------------------