@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKP7: (2017-10-27 )
MELLSGGEMLVRALADEGVEHVFGYPGGAVLHIYDALFQQDKINHYLVRHEQAAGHMADAYSRATGKTGVVLVTSGPGATNTVTPIATAYMDSIPMVVLSGQVASHLIGEDAFQETDMVGISRPIVKHSFQVRHASEIPAIIKKAFYIASSGRPGPVVVDIPKDATNPAEKFAYEYPEKVKMRSYQPPSRGHSGQIRKAIDELLTAKRPVIYTGGGVVQGNASALLTELAHLLGYPVTNTLMGLGGFPGDDPQFIGMLGMHGTYEANMAMHHADVILAIGARFDDRVTNNPAKFCPNSKVIHVDIDPATISKTIMAHIPIVGAVEPVLQEMLAQLKQLNVSKPNPEAIAAWWSQINEWRKVHGLKYENPSDGTMKPQQVVETLYKVTNGDAIITSDVGQHQMFGALYYKYKRPRQWINSGGLGTMGVGLPYAMAAKLAFPDQQVVCITGEASIQMCIQELSTCKQYGLNVKILCLNNRALGMVKQWQDMNYEGRHSSSYVESLPDFAKLMEAYGHVGIQINHADELESKLAEAMAINDKCVFINVMVDRSEHVYPMQVAGQSMRDMWISKGERI
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.....----..170.......180..---.--....190.----......200.......210.......-220.......230.......240.......250.......260.......270.......280.......290.....---------..---------300.......310.......320.......330.......340.......350.......360....-...370.-......380.......---390--........400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500-----.........510.......520.......530.......540.......550.......560.......570..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MELLS
G
G
E
M
L
V
R
A
L
A
D
E
G
V
E
H
V
FGYPG
G
A
V
L
H
I
Y
D
A
L
F
Q
QDKI
N
H
Y
L
V
R
H
E
Q
AAG
H
M
A
D
A
Y
SRATGKT
G
V
V
L
V
TSGPGATNT
V
T
P
I
A
T
A
Y
MDSI
P
M
V
V
LS
G
Q
V
A
S
H
L
IG
E
D
A
FQETDMVGISR
P
I
V
K
H
S
F
QVR
H
A
S
E
I
P
A
I
I
K
K
A
F
Y
I
ASSGRPG
P
V
V
V
DIPKDAT
N
----
P
A
E
K
F
A
Y
EY
P
E
K
VKMRS---Y--QPPSRGH
S
----
G
Q
I
R
K
A
I
D
E
L
L
TAKR
P
V
I
Y
TGGGVVQ-G
N
A
S
A
L
L
T
E
L
A
H
LLGY
P
V
T
N
T
L
M
GLGGFPGDDPQ
F
I
G
M
LGMHGTYEANMA
M
H
HA
D
V
I
L
A
IGARFDDRVTNN
P
A
KFCPN---------S
K
---------
V
I
H
V
DI
D
P
A
T
I
S
K
T
I
M
A
HIPIVG
A
V
E
P
V
L
Q
E
M
L
A
Q
L
K
QLNVSKP
N
P
E
A
I
A
A
W
W
S
Q
I
N
E
W
R
K
VHGLKY-ENPSDGT-M
K
P
Q
Q
V
V
E
T
L
Y
K
VTNG---
D
A
---
I
I
TSDVG
Q
H
Q
M
F
G
A
L
Y
Y
K
YK
R
P
R
Q
W
I
NSGGLGTMGVG
L
P
Y
A
M
A
A
KLAFPD
Q
Q
V
V
C
ITG
E
A
S
I
Q
M
C
I
Q
E
L
S
T
C
K
QYG
L
N
V
K
I
L
C
LNNRA
L
G
M
V
K
Q
W
QDMNYEGRHS
S
S
Y
V
-------
E
S
L
P
D
F
A
K
L
M
E
AYGHV
G
I
Q
I
N
H
A
D
E
L
E
S
K
L
A
E
A
MAIND
K
C
V
F
I
N
V
M
VDRSEH
V
Y
P
M
Q
V
A
G
Q
S
M
R
D
M
W
ISKGERI
2
PsiBlast_PDB
81.01
44%
-17
- C4 -
-
1T9A
7
ILVB_YEAST
A:
[82-656]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
------
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
---------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
---------
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
-------
K
E
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
--------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
-
V
A
G
G
S
G
L
D
E
F
I
N
-----
26
PsiBlast_CBE
80.54
44%
-39
- C4 -
-
1T9D
7
ILVB_YEAST
C:
[82-656]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
------
A
A
I
L
R
N
P
I
P
T
K
--------------------------
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
---------
A
R
R
A
A
A
E
GR
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
-------
K
E
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
--------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
-
V
A
G
G
S
G
L
D
E
F
I
N
-----
5
PsiBlast_PDB
80.40
44%
-19
- C4 -
-
1T9D
7
ILVB_YEAST
A:
[82-656]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
------
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
---------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
---------
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
-------
K
E
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
--------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
-
V
A
G
G
S
G
L
D
E
F
I
N
-----
29
PsiBlast_CBE
80.21
44%
-18
- C4 -
-
1T9B
7
ILVB_YEAST
B:
[82-656]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
------
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
----------
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
---------
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
-------
K
E
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
--------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
-
V
A
G
G
S
G
L
D
E
F
I
N
-----
27
PsiBlast_CBE
80.10
44%
-28
- C4 -
-
1T9D
7
ILVB_YEAST
B:
[82-656]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
------
A
A
I
L
R
N
P
I
P
---------------------F
V
M
-
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
---------
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
-------
K
E
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
--------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
-
V
A
G
G
S
G
L
D
E
F
I
N
-----
31
PsiBlast_CBE
79.98
44%
-20
- C4 -
-
1N0H
7
ILVB_YEAST
B:
[82-656]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
------
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
---------
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
---------
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
-------
K
E
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
--------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
-
V
A
G
G
S
G
L
D
E
F
I
N
-----
24
PsiBlast_CBE
79.78
44%
-17
- C4 -
-
5FEM
6
ILVB_YEAST
B:
[82-656]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
------
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
--------
T
S
R
A
Q
D
EFVM
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
---------
A
R
RAAAEGRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
-------
K
E
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
RHV
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
--------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
-
V
A
G
G
S
G
L
D
E
F
I
N
-----
30
PsiBlast_CBE
79.71
44%
-21
- C4 -
-
1T9A
7
ILVB_YEAST
B:
[82-656]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
------
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-------------
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
---------
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
-------
K
E
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
--------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
-
V
A
G
G
S
G
L
D
E
F
I
N
-----
3
PsiBlast_PDB
79.71
44%
-27
- C4 -
-
1T9B
7
ILVB_YEAST
A:
[82-656]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
------
A
A
I
L
R
N
P
I
P
---------------------F
V
M
-
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
---------
A
R
R
A
A
A
E
GRGG
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
-------
K
E
R
S
E
W
F
A
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
R
Y
S
H
T
H
--------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
-
V
A
G
G
S
G
L
D
E
F
I
N
-----