@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKQ5: (2017-10-28 )
MQFRKTLNIGIMLKIVLSEIGMTQGLLAGKRFLTAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEFAEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDGDFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGSERVMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASGIKSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDAGFNTVGMSQSMMDDE
Atome Classification :
(78 SA)
.........10........20........30........40-.--.--.......50........60---........70......--..80----------.--........90........100.......110.......120----..-.....130.......140.......150.......160.........170.......180.........190.......200.-......210.......220.......230.......240...----------....250......-.260.......270.......280......---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQF
R
K
TLN
I
G
I
M
L
K
I
V
L
S
EIGM
T
Q
G
L
L
AG
K
R
F
L
T
A
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
L
H
REG
A
E
L
A
F
T---YP
N
E
K
L
K
K
R
V
D
E
F
A
E
Q
--FGS-----------
K
--
L
V
F
PCD
V
A
V
DA
E
I
D
N
A
F
A
E
L
A
K
HWD
G
V
D
G
V
V
H
SIGFAPAHT----LD-GDFTDVTDRDG
F
K
I
A
HDI
S
A
Y
S
F
V
A
M
A
R
A
A
K
P
L
L
Q
A--RQG
C
L
L
T
L
T
YQGSERVMPNY--N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
S
SLGV-D
G
I
R
V
N
AISAG
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
LDANEKVAPLKRNV
T
----------
I
E
EVG
N
A
A
L
F
L
CS-PWASGIT
G
E
I
L
Y
V
DAGFNTVGMS
Q
S
MMDDE---
1
PsiBlast_PDB
97.83
99%
-127
- C4 -
-
4ZJU
1
?
A:
[11-270]
-----------------------
Q
G
L
L
A
G
K
R
F
L
I
A
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
L
H
R
E
G
A
E
L
A
F
T
---
Y
P
N
E
K
L
K
K
R
V
D
E
F
A
E
Q
--
F
G
S
-----------
K
--
L
V
F
P
C
D
V
A
V
D
A
E
I
D
N
A
F
A
E
L
A
K
H
W
D
G
V
D
G
V
V
H
S
I
G
F
A
P
A
H
T
----
L
D
-
G
D
F
T
D
V
T
D
R
D
G
F
K
I
A
H
D
I
S
A
Y
S
F
V
A
M
A
R
A
A
K
P
L
L
Q
A
--
R
Q
G
C
L
L
T
L
T
Y
Q
G
S
E
R
V
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
S
S
L
G
V
-
D
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
D
A
N
E
K
V
A
P
L
K
R
N
V
T
----------
I
E
E
V
G
N
A
A
L
F
L
C
S
-
P
W
A
S
G
I
T
G
E
I
L
Y
V
D
A
G
F
N
T
V
G
M
S
Q
S
--------
119
HHSearch
91.35
99%
-22
- C4 -
-
4ZJU
1
?
A:
[11-270]
-----------------------
Q
G
L
L
A
G
K
R
F
L
I
A
G
V
--
A
--
S
KL
S
--
I
A
Y
G
I
A
Q
A
L
H
R
E
G
A
E
L
A
F
T
---
Y
P
N
E
K
L
K
K
R
V
D
E
F
A
E
Q
--
F
G
S
-----------
K
--
L
V
F
P
C
D
V
A
V
D
A
E
I
D
N
A
F
A
E
L
A
K
H
W
D
G
V
D
G
V
V
H
S
I
G
F
A
P
A
H
T
----
L
D
-
G
D
F
T
D
V
T
D
R
D
G
F
K
I
A
H
D
I
S
A
Y
S
F
V
A
M
A
R
A
A
K
P
L
L
Q
A
--
R
Q
G
C
L
L
T
L
T
Y
Q
G
S
E
R
V
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
S
S
L
G
V
-
D
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
D
A
N
E
K
V
A
P
L
K
R
N
V
T
----------
I
E
E
V
G
N
A
A
L
F
L
C
S
-
P
W
A
S
G
I
T
G
E
I
L
Y
V
D
A
G
F
N
T
V
G
M
S
Q
S
--------
55
PsiBlast_CBE
88.04
65%
-124
- C4 -
-
3PJD
2
FABI_ECOLI
B:
[2-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
A
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
35
PsiBlast_CBE
88.00
65%
-126
- C4 -
-
1I2Z
2
FABI_ECOLI
B:
[2-258]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
5
PsiBlast_PDB
87.87
64%
-128
- C4 -
-
4JX8
2
FABI_ECOLI
A:
[21-278]
-----------------------
M
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
-
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
47
PsiBlast_CBE
87.83
65%
-124
- C4 -
-
1D8A
2
FABI_ECOLI
B:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
8
PsiBlast_PDB
87.67
65%
-127
- C4 -
-
1I2Z
2
FABI_ECOLI
A:
[2-258]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
7
PsiBlast_PDB
87.66
65%
-125
- C4 -
-
1C14
2
FABI_ECOLI
A:
[2-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
18
PsiBlast_PDB
87.64
65%
-119
- C4 -
-
1DFH
2
FABI_ECOLI
A:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
12
PsiBlast_PDB
87.63
65%
-124
- C4 -
-
1MFP
2
FABI_ECOLI
A:
[2-258]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
39
PsiBlast_CBE
87.60
65%
-123
- C4 -
-
1QG6
2
FABI_ECOLI
D:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
31
PsiBlast_CBE
87.50
65%
-123
- C4 -
-
1MFP
2
FABI_ECOLI
B:
[2-258]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
40
PsiBlast_CBE
87.43
65%
-123
- C4 -
-
1QG6
2
FABI_ECOLI
C:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
57
PsiBlast_CBE
87.42
65%
-124
- C4 -
-
3PJE
2
FABI_ECOLI
B:
[2-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
S
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
41
PsiBlast_CBE
87.37
65%
-123
- C4 -
-
1QG6
2
FABI_ECOLI
B:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
56
PsiBlast_CBE
87.35
65%
-128
- C4 -
-
3PJD
2
FABI_ECOLI
A:
[2-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
A
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
36
PsiBlast_CBE
87.34
65%
-121
- C4 -
-
1C14
2
FABI_ECOLI
B:
[2-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
20
PsiBlast_PDB
87.30
65%
-123
- C4 -
-
1QG6
2
FABI_ECOLI
A:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
4
PsiBlast_PDB
87.30
64%
-127
- C4 -
-
4JQC
2
FABI_ECOLI
A:
[21-278]
-----------------------
M
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
-
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
17
PsiBlast_PDB
87.13
65%
-124
- C4 -
-
1DFG
2
FABI_ECOLI
A:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
59
PsiBlast_CBE
87.10
65%
-128
- C4 -
-
3PJF
2
FABI_ECOLI
B:
[2-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
V
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
58
PsiBlast_CBE
86.66
65%
-124
- C4 -
-
3PJE
2
FABI_ECOLI
A:
[2-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
S
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
45
PsiBlast_CBE
86.59
65%
-121
- C4 -
-
1DFH
2
FABI_ECOLI
B:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
49
PsiBlast_CBE
86.16
65%
-125
- C4 -
-
4D46
2
?
B:
[2-256]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
------
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
-----------
32
PsiBlast_CBE
86.16
65%
-123
- C4 -
-
1LXC
2
FABI_ECOLI
B:
[2-258]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
-------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
46
PsiBlast_CBE
86.09
65%
-120
- C4 -
-
1DFG
2
FABI_ECOLI
B:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
77
PsiBlast_CBE
86.00
64%
-135
- C4 -
-
5I9N
2
?
A:
[2-254]
------------------------
G
F
L
D
G
K
R
I
L
L
T
G
L
L
S
N
--
R
--
S
--
I
A
Y
G
I
A
K
A
C
K
R
E
G
A
E
L
A
F
T
---
Y
V
G
D
R
F
K
D
R
I
T
E
F
A
A
E
--
F
G
S
-----------
E
--
L
V
F
P
C
D
V
A
D
D
A
Q
I
D
A
L
F
A
S
L
K
T
H
W
D
S
L
D
G
L
V
H
S
I
G
F
A
P
R
E
A
----
I
A
-
G
D
F
L
D
G
L
T
R
E
N
F
R
I
A
H
D
I
S
A
Y
S
F
P
A
L
A
K
A
A
L
P
M
L
-
S
--
D
D
A
S
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
T
M
G
L
A
K
A
A
L
E
A
S
V
R
Y
L
A
V
S
L
G
A
-
K
G
V
R
V
N
A
I
S
A
G
P
I
K
T
L
A
A
S
G
I
K
S
F
G
K
I
L
D
F
V
E
S
N
S
P
L
K
R
N
V
T
----------
I
E
Q
V
G
N
A
G
A
F
L
L
S
-
D
L
A
S
G
V
T
A
E
V
M
H
V
D
S
G
F
N
A
V
-------------
48
PsiBlast_CBE
85.98
65%
-122
- C4 -
-
1D8A
2
FABI_ECOLI
A:
[1-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
E
---------
23
PsiBlast_CBE
85.88
70%
-35
- C4 -
-
4NR0
2
FABI_PSEAE
B:
[2-260]
------------------------
G
F
L
T
G
K
R
A
L
I
V
G
V
A
S
K
--
L
--
S
--
I
A
S
G
I
A
A
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
R
G
R
V
E
E
F
A
S
G
--
W
G
S
-----------
R
PE
L
C
F
P
C
D
V
A
D
D
S
Q
I
E
A
V
F
A
A
L
G
K
H
W
D
G
L
D
I
I
V
H
S
V
G
F
A
P
G
D
Q
----
L
D
-
G
D
F
T
A
V
T
T
R
E
G
F
R
I
A
H
D
I
S
A
Y
S
F
I
A
L
A
K
A
G
R
E
M
M
K
G
--
R
N
G
S
L
L
T
L
S
Y
L
G
A
E
R
T
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
G
S
L
G
A
-
E
G
T
R
V
N
A
V
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
A
A
N
E
R
Q
T
P
L
R
R
N
V
T
----------
I
E
E
V
G
N
A
G
A
F
L
C
S
-
D
L
A
S
G
I
S
G
E
I
L
Y
V
D
G
G
F
N
T
T
A
M
G
----------
9
PsiBlast_PDB
85.86
65%
-126
- C4 -
-
1I30
2
FABI_ECOLI
A:
[2-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
--------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
78
PsiBlast_CBE
85.81
64%
-133
- C4 -
-
5I9M
2
?
C:
[2-254]
------------------------
G
F
L
D
G
K
R
I
L
L
T
G
L
L
S
N
--
R
--
S
--
I
A
Y
G
I
A
K
A
C
K
R
E
G
A
E
L
A
F
T
---
Y
V
G
D
R
F
K
D
R
I
T
E
F
A
A
E
--
F
G
S
-----------
E
--
L
V
F
P
C
D
V
A
D
D
A
Q
I
D
A
L
F
A
S
L
K
T
H
W
D
S
L
D
G
L
V
H
S
I
G
F
A
P
R
E
A
----
I
A
-
G
D
F
L
D
G
L
T
R
E
N
F
R
I
A
H
D
I
S
A
Y
S
F
P
A
L
A
K
A
A
L
P
M
L
-
S
--
D
D
A
S
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
T
M
G
L
A
K
A
A
L
E
A
S
V
R
Y
L
A
V
S
L
G
A
-
K
G
V
R
V
N
A
I
S
A
G
P
I
K
T
L
A
A
S
G
I
K
S
F
G
K
I
L
D
F
V
E
S
N
S
P
L
K
R
N
V
T
----------
I
E
Q
V
G
N
A
G
A
F
L
L
S
-
D
L
A
S
G
V
T
A
E
V
M
H
V
D
S
G
F
N
A
V
-------------
15
PsiBlast_PDB
85.78
65%
-126
- C4 -
-
5CG1
2
FABI_ECOLI
A:
[45-300]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
-
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
---------
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
22
PsiBlast_CBE
85.67
70%
-35
- C4 -
-
4NR0
2
FABI_PSEAE
C:
[2-262]
------------------------
G
F
L
T
G
K
R
A
L
I
V
G
V
A
S
K
--
L
--
S
--
I
A
S
G
I
A
A
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
R
G
R
V
E
E
F
A
S
G
--
W
G
S
-----------
R
PE
L
C
F
P
C
D
V
A
D
D
S
Q
I
E
A
V
F
A
A
L
G
K
H
W
D
G
L
D
I
I
V
H
S
V
G
F
A
P
G
D
Q
----
L
D
-
G
D
F
T
A
V
T
T
R
E
G
F
R
I
A
H
D
I
S
A
Y
S
F
I
A
L
A
K
A
G
R
E
M
M
K
G
--
R
N
G
S
L
L
T
L
S
Y
L
G
A
E
R
T
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
G
S
L
G
A
-
E
G
T
R
V
N
A
V
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
A
A
N
E
R
Q
T
P
L
R
R
N
V
T
----------
I
E
E
V
G
N
A
G
A
F
L
C
S
-
D
L
A
S
G
I
S
G
E
I
L
Y
V
D
G
G
F
N
T
T
A
M
G
P
--
L
------
34
PsiBlast_CBE
85.65
65%
-124
- C4 -
-
1I30
2
FABI_ECOLI
B:
[2-257]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
A
-
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
--------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
80
PsiBlast_CBE
85.54
64%
-133
- C4 -
-
5I9M
2
?
A:
[2-254]
------------------------
G
F
L
D
G
K
R
I
L
L
T
G
L
L
S
N
--
R
--
S
--
I
A
Y
G
I
A
K
A
C
K
R
E
G
A
E
L
A
F
T
---
Y
V
G
D
R
F
K
D
R
I
T
E
F
A
A
E
--
F
G
S
-----------
E
--
L
V
F
P
C
D
V
A
D
D
A
Q
I
D
A
L
F
A
S
L
K
T
H
W
D
S
L
D
G
L
V
H
S
I
G
F
A
P
R
E
A
----
I
A
-
G
D
F
L
D
G
L
T
R
E
N
F
R
I
A
H
D
I
S
A
Y
S
F
P
A
L
A
K
A
A
L
P
M
L
-
S
--
D
D
A
S
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
T
M
G
L
A
K
A
A
L
E
A
S
V
R
Y
L
A
V
S
L
G
A
-
K
G
V
R
V
N
A
I
S
A
G
P
I
K
T
L
A
A
S
G
I
K
S
F
G
K
I
L
D
F
V
E
S
N
S
P
L
K
R
N
V
T
----------
I
E
Q
V
G
N
A
G
A
F
L
L
S
-
D
L
A
S
G
V
T
A
E
V
M
H
V
D
S
G
F
N
A
V
-------------
3
PsiBlast_PDB
85.54
70%
-34
- C4 -
-
4NR0
2
FABI_PSEAE
A:
[2-260]
------------------------
G
F
L
T
G
K
R
A
L
I
V
G
V
A
S
K
--
L
--
S
--
I
A
S
G
I
A
A
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
R
G
R
V
E
E
F
A
S
G
--
W
G
S
-----------
R
PE
L
C
F
P
C
D
V
A
D
D
S
Q
I
E
A
V
F
A
A
L
G
K
H
W
D
G
L
D
I
I
V
H
S
V
G
F
A
P
G
D
Q
----
L
D
-
G
D
F
T
A
V
T
T
R
E
G
F
R
I
A
H
D
I
S
A
Y
S
F
I
A
L
A
K
A
G
R
E
M
M
K
G
--
R
N
G
S
L
L
T
L
S
Y
L
G
A
E
R
T
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
G
S
L
G
A
-
E
G
T
R
V
N
A
V
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
A
A
N
E
R
Q
T
P
L
R
R
N
V
T
----------
I
E
E
V
G
N
A
G
A
F
L
C
S
-
D
L
A
S
G
I
S
G
E
I
L
Y
V
D
G
G
F
N
T
T
A
M
G
----------
21
PsiBlast_CBE
85.49
70%
-36
- C4 -
-
4NR0
2
FABI_PSEAE
D:
[2-262]
------------------------
G
F
L
T
G
K
R
A
L
I
V
G
V
A
S
K
--
L
--
S
--
I
A
S
G
I
A
A
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
R
G
R
V
E
E
F
A
S
G
--
W
G
S
-----------
R
PE
L
C
F
P
C
D
V
A
D
D
S
Q
I
E
A
V
F
A
A
L
G
K
H
W
D
G
L
D
I
I
V
H
S
V
G
F
A
P
G
D
Q
----
L
D
-
G
D
F
T
A
V
T
T
R
E
G
F
R
I
A
H
D
I
S
A
Y
S
F
I
A
L
A
K
A
G
R
E
M
M
K
G
--
R
N
G
S
L
L
T
L
S
Y
L
G
A
E
R
T
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
G
S
L
G
A
-
E
G
T
R
V
N
A
V
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
A
A
N
E
R
Q
T
P
L
R
R
N
V
T
----------
I
E
E
V
G
N
A
G
A
F
L
C
S
-
D
L
A
S
G
I
S
G
E
I
L
Y
V
D
G
G
F
N
T
T
A
M
G
P
--
L
------
87
PsiBlast_CBE
85.48
64%
-131
- C4 -
-
5I7S
2
?
A:
[2-254]
------------------------
G
F
L
D
G
K
R
I
L
L
T
G
L
L
S
N
--
R
--
S
--
I
A
Y
G
I
A
K
A
C
K
R
E
G
A
E
L
A
F
T
---
Y
V
G
D
R
F
K
D
R
I
T
E
F
A
A
E
--
F
G
S
-----------
E
--
L
V
F
P
C
D
V
A
D
D
A
Q
I
D
A
L
F
A
S
L
K
T
H
W
D
S
L
D
G
L
V
H
S
I
G
F
A
P
R
E
A
----
I
A
-
G
D
F
L
D
G
L
T
R
E
N
F
R
I
A
H
D
I
S
A
Y
S
F
P
A
L
A
K
A
A
L
P
M
L
-
S
--
D
D
A
S
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
T
M
G
L
A
K
A
A
L
E
A
S
V
R
Y
L
A
V
S
L
G
A
-
K
G
V
R
V
N
A
I
S
A
G
P
I
K
T
L
A
A
S
G
I
K
S
F
G
K
I
L
D
F
V
E
S
N
S
P
L
K
R
N
V
T
----------
I
E
Q
V
G
N
A
G
A
F
L
L
S
-
D
L
A
S
G
V
T
A
E
V
M
H
V
D
S
G
F
N
A
V
-------------
86
PsiBlast_CBE
85.45
64%
-132
- C4 -
-
5I7V
2
?
A:
[2-254]
------------------------
G
F
L
D
G
K
R
I
L
L
T
G
L
L
S
N
--
R
--
S
--
I
A
Y
G
I
A
K
A
C
K
R
E
G
A
E
L
A
F
T
---
Y
V
G
D
R
F
K
D
R
I
T
E
F
A
A
E
--
F
G
S
-----------
E
--
L
V
F
P
C
D
V
A
D
D
A
Q
I
D
A
L
F
A
S
L
K
T
H
W
D
S
L
D
G
L
V
H
S
I
G
F
A
P
R
E
A
----
I
A
-
G
D
F
L
D
G
L
T
R
E
N
F
R
I
A
H
D
I
S
A
Y
S
F
P
A
L
A
K
A
A
L
P
M
L
-
S
--
D
D
A
S
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
T
M
G
L
A
K
A
A
L
E
A
S
V
R
Y
L
A
V
S
L
G
A
-
K
G
V
R
V
N
A
I
S
A
G
P
I
K
T
L
A
A
S
G
I
K
S
F
G
K
I
L
D
F
V
E
S
N
S
P
L
K
R
N
V
T
----------
I
E
Q
V
G
N
A
G
A
F
L
L
S
-
D
L
A
S
G
V
T
A
E
V
M
H
V
D
S
G
F
N
A
V
-------------
100
PsiBlast_CBE
85.44
64%
-133
- C4 -
-
4BKU
2
?
A:
[2-254]
------------------------
G
F
L
D
G
K
R
I
L
L
T
G
L
L
S
N
--
R
--
S
--
I
A
Y
G
I
A
K
A
C
K
R
E
G
A
E
L
A
F
T
---
Y
V
G
D
R
F
K
D
R
I
T
E
F
A
A
E
--
F
G
S
-----------
E
--
L
V
F
P
C
D
V
A
D
D
A
Q
I
D
A
L
F
A
S
L
K
T
H
W
D
S
L
D
G
L
V
H
S
I
G
F
A
P
R
E
A
----
I
A
-
G
D
F
L
D
G
L
T
R
E
N
F
R
I
A
H
D
I
S
A
Y
S
F
P
A
L
A
K
A
A
L
P
M
L
-
S
--
D
D
A
S
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
T
M
G
L
A
K
A
A
L
E
A
S
V
R
Y
L
A
V
S
L
G
A
-
K
G
V
R
V
N
A
I
S
A
G
P
I
K
T
L
A
A
S
G
I
K
S
F
G
K
I
L
D
F
V
E
S
N
S
P
L
K
R
N
V
T
----------
I
E
Q
V
G
N
A
G
A
F
L
L
S
-
D
L
A
S
G
V
T
A
E
V
M
H
V
D
S
G
F
N
A
V
-------------
38
PsiBlast_CBE
85.33
65%
-129
- C4 -
-
5CG1
2
FABI_ECOLI
B:
[45-300]
------------------------
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
--
L
--
S
--
I
A
Y
G
I
A
Q
A
M
H
R
E
G
A
E
L
A
F
T
---
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
--
L
G
S
-----------
D
--
I
V
L
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
----
L
D
-
G
D
Y
V
N
A
V
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
N
P
--
G
S
-
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
--------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
V
T
----------
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
I
A
A
M
N
----------
79
PsiBlast_CBE
85.28
64%
-133
- C4 -
-
5I9M
2
?
B:
[2-254]
------------------------
G
F
L
D
G
K
R
I
L
L
T
G
L
L
S
N
--
R
--
S
--
I
A
Y
G
I
A
K
A
C
K
R
E
G
A
E
L
A
F
T
---
Y
V
G
D
R
F
K
D
R
I
T
E
F
A
A
E
--
F
G
S
-----------
E
--
L
V
F
P
C
D
V
A
D
D
A
Q
I
D
A
L
F
A
S
L
K
T
H
W
D
S
L
D
G
L
V
H
S
I
G
F
A
P
R
E
A
----
I
A
-
G
D
F
L
D
G
L
T
R
E
N
F
R
I
A
H
D
I
S
A
Y
S
F
P
A
L
A
K
A
A
L
P
M
L
-
S
--
D
D
A
S
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
T
M
G
L
A
K
A
A
L
E
A
S
V
R
Y
L
A
V
S
L
G
A
-
K
G
V
R
V
N
A
I
S
A
G
P
I
K
T
L
A
A
S
G
I
K
S
F
G
K
I
L
D
F
V
E
S
N
S
P
L
K
R
N
V
T
----------
I
E
Q
V
G
N
A
G
A
F
L
L
S
-
D
L
A
S
G
V
T
A
E
V
M
H
V
D
S
G
F
N
A
V
-------------