@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKT6: (2017-10-29 )
MLLVYTLIAIVALIVMIAKFRIYPFLVLIIVSLGLALAVGMPMDGIVKSYEAGTGKTLGHLAIVIALGSMLGKMMAESGGAERIAIALIKWFGEKHIHWAMMFIALIVGLPVFFEVGFVLLIPIAFNIAKRTGKSLLIVGLPMVAGLSVVHGLIPPHPAALLAVQAYHADIGKTIMYSLLVGVPTAVVAGPLYALWINKYVKLPENNPLAKQFVEADANNTRELPSFGITLFTIMLPVALMLVGSWADVFFAPKTFPNELLRFIGTSDIALLIAVLVSFITFGTMQGFNREQIEKFCGGCLASIAGILLIVGAGGGFGGILRDSGISNEIVSTALKANLSPLLLGWLVAAIIRLATGSATVAMATACSIVAPIAAAAGVVVRPELLVLATGSGSLIFSHVNDAGFWLIKEYFGMTVGQTLKTWSVLETIISVLGLSFTLLLSAVL
Atome Classification :
(20 SA)
-------....---.-....10........20........30..---..----....40..---..---....50........60........70........-80........90..--.-.------.-.--..100......-.110.-.-.....120-------------....-....----------130......-----.140---------..-.-.--...150.......-.-.160.--.--.--.-.--.-------..170-.-----........-180.......190..--.....200.......-210...---....220......----.230.....--...240....-..--.250.-..-....260....-.-.-.---.--270.....-..280.---...---..-.290.......300.......310-----..-------....------...320.......330.....--.---.--340-----..---.----.--.-...-------350.--------....--..--360.......370....-----...-380-.......390.--.---.....400--------------------.......410-------.----...-...420.......430.......440...-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------M
L
L
V
---
Y
-
T
L
I
A
I
V
A
L
I
V
M
I
A
K
F
R
I
Y
P
F
L
V
L
I
I
V
S
L
---
G
L
----
A
L
AVGM
P
M
---
D
G
---
I
V
K
S
YEAGTGK
T
L
G
H
L
A
I
V
I
A
L
G
S
M
L
G
K
M
M
A
ESG-GA
E
R
I
A
I
A
L
I
K
W
FG--E-K------
H
-
I
--
H
W
A
M
M
F
I
A
L
I
V-G
L
P
V
F
-
F
-EVG
F
V
L
L
--------------
I
P
I
A
-
F
N
I
A
----------
K
RTG
K
S
L
L
I
-----
V
G
L
P
---------
M
V
-
A
-
G
--
L
S
V
V
--
H
GLIPPH-
P
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A
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V
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Y
-------
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D
---
I
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G
K
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S
L
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L
VGV
P
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V
VAG
P
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Y
A
--
L
W
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VKLPEN
N
P
L
-
A
K
Q
F
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---ADANNTRELPSF
G
----
I
T
-
L
F
T
I
M
L
--
P
V
A
L
M
L
V
GSW-A
D
--
V
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FAP-KT-
F
P
N
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S
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D
---
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--
A
L
L
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V
L
V
-
S
F
I
T
F
G
---TMQ---GF-
N
R
E
Q
I
E
K
F
C
G
G
C
L
A
S
I
A
G
I
L
L
I
-------
V
G-------AGGG------FGGILRDSGI
S
N
E
I
V
S
T
A
L
KA--N---
L
--
S
P
------
L
L
---
L
----
G
--
W
-
L
V
A
-------
A
I
I
R
--------LATG--S
A
--
T
V
A
M
A
T
A
C
S
I
V
A
P
I
A
A
A-----AG
V
-
V
VR-
P
E
L
L
V
L
ATGSG--
S
---
L
I
F
S
HVND--------------------
A
G
F
W
L
I
K
E
Y
F-------G----
M
T
V-G
Q
T
L
K
T
W
S
V
L
E
T
I
I
S
V
L
G
L
S
F
T
L
L
L
S
A
VL-----------------------
33
HHSearch
65.37
15%
-107
- C3 -
-
4R0C
5
?
C:
[64-484]
----------------------------------------------------------
D
G
L
---
R
Y
---
L
F
T
T
L
V
G
N
F
T
G
F
-
A
P
L
G
-
V
V
L
V
A
M
L
G
L
G
V
A
E
Q
S
G
-
L
L
S
V
S
L
A
S
L
V
R
R
S
S
--
G
-
G
------
A
-
L
--
V
-
F
T
V
A
F
A
G
V
L
-
S
S
L
-
T
-
V
-
D
A
G
Y
V
V
L
--------------
I
P
L
A
-
G
L
V
F
----------
Q
L
A
G
R
P
P
I
A
-----
G
I
A
T
---------
A
F
-
A
-
A
V
S
G
G
F
S
--
A
N
L
L
V
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P
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V
-
D
A
T
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L
A
G
L
--
S
T
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A
--
A
H
I
IDPD
R
T
V
A
---
A
-----
T
G
N
Y
W
F
I
I
-
A
S
T
F
L
V
T
G
L
-
V
T
L
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L
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L
A
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A
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T
V
A
-
D
A
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-
V
D
---
A
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Q
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K
W
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----
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L
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L
L
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--
G
L
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L
L
V
L
P
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D
--
A
--
P
L
R
H
P
-
D
T
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G
--
S
V
----
L
G
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S
-
P
-
F
I
H
G
L
--
V
V
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V
A
L
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A
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G
I
C
G
A
V
---
Y
G
R
V
S
G
Q
F
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S
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A
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T
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M
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Y
L
V
L
-------
M
F
-------
F
A
A
Q
------
F
V
A
W
F
N
Y
S
Q
L
G
L
L
L
A
V
K
G
A
A
W
L
-
G
A
L
T
V
--
P
K
------
V
V
L
L
L
L
----
F
--
V
-
V
L
T
-------
A
L
I
N
--------
L
M
I
G
--
S
A
--
S
A
K
W
S
I
L
A
P
V
F
I
P
M
L
M
L
-----
L
G
---
I
S
-
P
E
A
S
Q
A
A
Y
R
V
G
--
D
S
S
T
N
I
I
T
P
L
M
P
--------------------
Y
-
F
V
L
V
L
G
F
A
R
------
R
YQPE
T
G
I
-
G
T
L
I
A
L
M
L
P
Y
S
L
T
L
L
L
G
W
S
V
L
L
G
V
W
I
--------------------------
34
HHSearch
65.21
15%
-112
- C3 -
-
4R0C
1
?
D:
[64-484]
----------------------------------------------------------
D
G
L
---
R
Y
---
L
F
T
T
L
V
G
N
F
T
G
F
-
A
P
L
G
-
V
V
L
V
A
M
L
G
L
G
V
A
E
Q
S
G
-
L
L
S
V
S
L
A
S
L
V
R
R
S
S
--
G
-
G
------
A
-
L
--
V
-
F
T
V
A
F
A
G
V
L
-
S
S
L
-
T
-
V
-
D
A
G
Y
V
V
L
--------------
I
P
L
A
-
G
L
V
F
----------
Q
L
A
G
R
P
P
I
A
-----
G
I
A
T
---------
A
F
-
A
-
A
V
S
G
G
F
S
--
A
N
L
L
V
G
P
-
V
-
D
A
T
-
L
A
G
L
--
S
T
-
E
-
A
--
A
H
I
IDPD
R
T
V
A
---
A
-----
T
G
N
Y
W
F
I
I
-
A
S
T
F
L
V
T
G
L
-
V
T
L
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T
--
R
T
L
T
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P
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L
A
H
A
N
T
V
A
-
D
A
S
-
V
D
---
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S
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A
M
K
W
T
G
----
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--
G
L
A
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V
L
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--
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--
P
L
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P
-
D
T
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--
S
V
----
L
G
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S
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P
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F
I
H
G
L
--
V
V
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V
A
L
I
A
-
G
I
C
G
A
V
---
Y
G
R
V
S
G
Q
F
R
N
S
G
A
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T
A
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A
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Y
L
V
L
-------
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F
-------
F
A
A
Q
------
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V
A
W
F
N
Y
S
Q
L
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L
L
L
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V
K
G
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A
W
L
-
G
A
L
T
V
--
P
K
------
V
V
L
L
L
L
----
F
--
V
-
V
L
T
-------
A
L
I
N
--------
L
M
I
G
--
S
A
--
S
A
K
W
S
I
L
A
P
V
F
I
P
M
L
M
L
-----
L
G
---
I
S
-
P
E
A
S
Q
A
A
Y
R
V
G
--
D
S
S
T
N
I
I
T
P
L
M
P
--------------------
Y
-
F
V
L
V
L
G
F
A
R
------
R
Y
QPE
T
G
I
-
G
T
L
I
A
L
M
L
P
Y
S
L
T
L
L
L
G
W
S
V
L
L
G
V
W
I
--------------------------
35
HHSearch
64.68
16%
-
- C3 -
-
4R1I
-
?
B:
[77-504]
----------------------------------------------------------
D
G
L
---
I
K
---
I
L
T
H
T
V
K
N
F
T
G
F
-
A
P
L
G
T
-
V
L
V
S
L
L
G
V
G
I
A
E
K
S
G
-
L
I
S
A
L
M
R
L
L
L
T
K
S
P
--
R
-
K
------
L
-
T
--
T
F
-
M
V
V
F
T
G
I
L
-
S
N
T
-
A
-
S
-
E
L
G
Y
V
V
L
--------------
I
P
L
S
-
A
V
I
F
----------
H
S
L
G
R
H
P
L
A
-----
G
L
A
A
---------
A
F
-
A
-
G
--
V
S
G
G
YS
A
N
L
F
L
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T
-
I
-
D
P
L
-
L
--
A
G
I
T
--
Q
Q
A
--
A
-------
Q
I
I
HPD
Y
VVGPE
A
N
W
F
F
M
A
A
-
S
-
T
F
V
I
A
L
I
-
G
Y
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--
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Q
L
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D
L
-
S
Q
E
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K
---
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I
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L
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L
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V
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---
L
--
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S
---
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M
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L
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L
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-------
I
F
-------
F
A
A
Q
------
F
V
A
F
F
N
W
T
N
I
G
Q
Y
I
A
V
K
G
A
V
F
L
K
E
---
V
GL
A
G
------
S
V
L
F
I
G
----
F
--
I
-
L
I
C
-------
A
F
I
N
--------
L
M
I
G
--
S
A
--
S
A
Q
W
A
V
T
A
P
I
F
V
P
M
L
M
L
-----
A
G
---
Y
A
-
P
E
V
I
Q
A
A
Y
R
I
G
--
D
S
V
T
N
I
I
T
P
M
M
S
--------------------
Y
F
G
L
I
M
A
T
V
M
K
YKK---
D
----
A
G
V
-
G
T
L
I
S
M
M
L
P
Y
S
A
F
F
L
I
A
W
I
A
L
F
C
I
W
V
--------------------------
36
HHSearch
64.66
16%
-
- C3 -
-
4R1I
-
?
A:
[77-504]
----------------------------------------------------------
D
G
L
---
I
K
---
I
L
T
H
T
V
K
N
F
T
G
F
-
A
P
L
G
T
-
V
L
V
S
L
L
G
V
G
I
A
E
K
S
G
-
L
I
S
A
L
M
R
L
L
L
T
K
S
P
--
R
-
K
------
L
-
T
--
T
F
-
M
V
V
F
T
G
I
L
-
S
N
T
-
A
-
S
-
E
L
G
Y
V
V
L
--------------
I
P
L
S
-
A
V
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F
----------
H
S
L
G
R
H
P
L
A
-----
G
L
A
A
---------
A
F
-
A
-
G
--
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G
YS
A
N
L
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L
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T
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-
D
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L
-
L
--
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T
--
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Q
A
--
A
-------
Q
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HPD
Y
V
V
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A
N
W
F
F
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A
-
S
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L
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Y
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K
I
V
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L
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P
Y
Q
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D
L
-
S
Q
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K
---
D
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A
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L
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L
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A
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S
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L
-
K
S
I
V
-
V
F
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F
L
---
L
--
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A
L
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Y
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T
-----
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S
---
L
R
-
G
E
R
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V
V
N
A
M
A
E
S
M
S
T
L
G
L
Y
L
V
I
-------
I
F
-------
F
A
A
Q
------
F
V
A
F
F
N
W
T
N
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G
Q
Y
I
A
V
K
G
A
V
F
L
K
E
---
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GL
A
G
------
S
V
L
F
I
G
----
F
--
I
-
L
I
C
-------
A
F
I
N
--------
L
M
I
G
--
S
A
--
S
A
Q
W
A
V
T
A
P
I
F
V
P
M
L
M
L
-----
A
G
---
Y
A
-
P
E
V
I
Q
A
A
Y
R
I
G
--
D
S
V
T
N
I
I
T
P
M
M
S
--------------------
Y
F
G
L
I
M
A
T
V
M
K
Y
KK---
D
----
A
G
V
-
G
T
L
I
S
M
M
L
P
Y
S
A
F
F
L
I
A
W
I
A
L
F
C
I
W
V
--------------------------
27
Fugue
64.30
20%
-70
- C1 -
-
4D7E
1
?
A:
[1-413]
----ME
T
L
L
V
V
GAG
P
-
K
A
L
A
V
A
A
K
S
H
V
L
R
Q
L
G
L
S
A
P
R
V
I
A
V
E
A
H
AVG
G
N
----
W
L
A
S
G
G
W
T
---
D
G
RHR
L
G
T
S
P
E
K
D
I
G
F
P
Y
H
S
T
W
A
R
G
H
N
R
E
I
N
E
A
M
M
A
F
S
W
-
T
S
F
L
V
E
H
G
T
Y
A
E
W
I
--
D
-
R
GRPSPQ
H
-
H
--
V
W
A
K
Y
L
Q
W
V
A
R
-
K
I
D
L
E
-
L
-
V
L
G
K
V
R
T
--------------
I
R
Q
G
-
W
S
V
E
----------
V
A
G
A
T
T
E
L
E
-----
A
D
G
L
---------
M
I
-
T
-
G
--
P
G
Q
S
--
T
K
A
L
A
A
H
-
P
-
R
-
V
-
L
--
S
--
I
--
A
-
E
--
F
-------
W
D
L
---
A
-----
G
K
---
R
K
L
-
P
I
S
S
R
A
A
V
I
G
G
G
--------------------------
E
---
T
A
G
S
A
L
D
E
L
V
R
H
E
----
M
L
-
T
I
S
V
I
S
--
P
M
A
----
S
Y
F
-
E
N
--
S
L
F
S
D
-
P
T
-
K
W
N
A
L
S
-
I
Q
E
R
-
R
-
D
-
V
---
I
--
R
R
T
D
R
G
V
F
-
S
V
R
V
Q
E
---
S
L
L
---
G
D
-
N
R
--
V
H
H
L
Q
G
-------
R
V
T
R
I
-------
V
G
-------
Q
G
D
G
------
V
A
V
T
L
R
N
E
M
R
A
D
Q
V
H
N
F
D
L
V
V
--
D
---
A
--
T
G
------
G
Q
---
P
----
L
--
W
-
F
L
D
L
FD
S
E
S
A
D
L
L
E
--------
L
A
V
G
--
G
P
--
L
T
Q
Q
R
I
E
S
S
I
G
Y
D
L
A
V
T
GL---
G
A
K
-
L
Y
L
-
P
N
M
A
A
L
A
Q
G
P
G
--------
F
P
N
--------------------------------------------------------------
L
S
C
L
G
E
L
S
D
R
V
L
R
--------------------------
24
Fugue
63.68
19%
-
* C6 *
-
4O2X
-
MALE_ECOLI
A:
[5-483]
---EG
K
L
V
I
W
I
---
N
-
G
D
K
G
Y
N
G
L
A
E
V
G
K
K
F
E
K
D
T
------------
G
I
----
K
V
T
V
E
H
P
----
D
K
---
L
E
E
K
F
P
Q
-
V
A
A
T
G
D
G
P
D
I
I
F
W
A
H
D
R
F
G
G
Y
A
Q
S
G
L
-
L
A
E
I
T
P
D
K
A
F
Q
D
K
L
--
Y
-
P
------
F
-
T
--
W
D
A
V
R
Y
N
G
K
L
I
-
A
Y
P
I
A
-
V
-
E
A
L
S
L
I
Y
N
KDLLPNPPKTWEE
I
P
A
L
-
D
K
E
L
----------
K
A
K
G
K
S
A
L
M
-----
F
N
L
Q
---------
E
-----------------
P
Y
F
-
T
-
W
P
L
-
I
--
A
-------------------
A
D
---
G
-----
G
Y
A
F
K
Y
E
N
G
K
Y
D
I
K
D
V
G
V
D
N
A
G
A
K
--
A
G
L
T
F
L
V
D
L
I
K
N
K
H
M
-
N
A
---
D
---
T
D
Y
S
I
A
E
A
A
F
N
K
G
----
E
T
-
A
M
T
I
N
G
--
P
W
A
------
W
-
S
N
--
I
D
T
S
K
-
V
N
-
Y
G
V
T
V
L
-
P
T
F
K
-
G
-
Q
-
P
---
S
--
K
P
F
V
G
V
L
S
-
A
G
I
N
------
A
A
---
S
P
-
N
K
E
L
A
K
E
F
L
E
N
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
KPLG
A
V
-------
A
L
K
S
------
Y
E
E
E
L
A
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
--
E
---
I
--
M
P
NIPQ
M
S
A
F
---
W
----
Y
--
A
-
V
R
T
-------
A
V
I
N
--------
A
A
S
G
--
R
Q
--
T
V
D
E
A
L
A
---
A
A
Q
T
N
A
A
-----
A
N
L
-
E
K
I
-
K
K
L
R
N
V
I
T
S
A
W
--
K
---
V
I
L
Y
N
D
D
I
--------------------
H
N
F
T
Y
V
T
D
V
I
-------
V
----
K
V
V
-
G
Q
-
I
S
K
A
K
A
H
T
I
T
V
E
A
H
S
T
G
Q
A
L
I
L
S
T
W
K
S
K
A
E
K
Y
C
Q
E
L
Q
Q
N
G
L
T
V
S
I
I
H
ES
31
HHSearch
59.39
13%
-132
- C3 -
-
5ULE
1
?
C:
[35-444]
--------------------
L
A
F
I
A
V
L
W
L
T
E
A
L
H
V
T
V
T
A
I
L
V
P
V
---
M
A
----
V
F
F
G
I
F
E
T
----------
Q
A
A
L
N
N
F
A
N
---
S
I
I
F
L
F
L
G
G
F
A
L
A
A
A
M
H
H
Q
G
-
L
D
K
V
I
A
D
K
V
L
A
M
A
Q
--
G
K
M
------
S
V
A
--
V
F
M
L
F
G
V
T
A
L
L
-
S
M
W
I
S
-
N
-
T
A
T
A
A
M
M
--------------
L
P
L
V
-
L
G
V
L
----------
S
K
V
D
A
D
K
Q
R
STYVF
V
L
L
G
---------
V
A
-
Y
-
S
--
A
S
I
G
--
G
I
A
T
L
V
G
T
G
-
P
N
A
-
I
--
A
--
A
--
A
-
E
--
V
-------
G
L
S
---
F
-----
T
D
W
M
K
F
G
L
-
P
T
A
M
M
M
L
P
M
-
A
I
A
I
L
--
Y
F
L
L
K
P
T
L
N
G
M
F
-
E
L
-----------
D
R
A
P
V
N
W
D
K
G
K
V
----
V
T
-
L
G
I
F
G
L
--
T
V
F
L
W
I
F
S
S
P
-
I
N
--
A
------------
A
L
-
G
G
F
K
S
F
-
D
-
T
---
L
--
V
A
L
G
A
I
L
M
-
L
S
-
F
A
-----
R
----
V
V
-
H
W
K
E
I
Q
K
T
A
D
------
W
G
I
L
L
L
-------
F
G
-------
G
G
L
C
------
L
S
N
V
L
K
Q
T
G
T
S
V
F
L
A
N
A
L
S
D
M
V-
S
H--
M
--
G
I
------
F
V
---
V
----
I
LV
V
-
A
T
F
-------
V
V
F
L
--------
T
E
F
T
--
S
N
--
V
A
T
T
T
L
L
I
P
V
F
A
T
V
A
E
A
-----
F
G
---
M
S
-
P
V
L
L
S
V
L
I
A
V
A
AS
C
---
A
F
M
L
P
V
A
T
--------------------
P
P
N
A
I
V
F
A
S
G
-------
H
----
I
K
Q
-
S
E
M
M
R
V
G
L
Y
L
N
I
A
C
I
G
L
L
T
A
I
A
M
L
F
W
--------------------------
32
HHSearch
59.12
13%
-132
- C3 -
-
5ULD
1
?
C:
[35-444]
--------------------
L
A
F
I
A
V
L
W
L
T
E
A
L
H
V
T
V
T
A
I
L
V
P
V
---
M
A
----
V
F
F
G
I
F
E
T
----------
Q
A
A
L
N
N
F
A
N
---
S
I
I
F
L
F
L
G
G
F
A
L
A
A
A
M
H
H
Q
G
-
L
D
K
V
I
A
D
K
V
L
A
M
A
Q
--
G
K
M
------
S
V
A
--
V
F
M
L
F
G
V
T
A
L
L
-
S
M
W
I
S
-
N
-
T
A
T
A
A
M
M
--------------
L
P
L
V
-
L
G
V
L
----------
S
K
V
D
A
D
K
Q
R
STYVF
V
L
L
G
---------
V
A
-
Y
-
S
--
A
S
I
G
--
G
I
A
T
L
V
G
T
G
-
P
N
A
-
I
--
A
--
A
--
A
-
E
--
V
-------
G
L
S
---
F
-----
T
D
W
M
K
F
G
L
-
P
T
A
M
M
M
L
P
M
-
A
I
A
I
L
--
Y
F
L
L
K
P
T
L
N
G
M
F
-
E
L
-----------
D
R
A
P
V
N
W
D
K
G
K
V
----
V
T
-
L
G
I
F
G
L
--
T
V
F
L
W
I
F
S
S
P
-
I
N
--
A
------------
A
L
-
G
G
F
K
S
F
-
D
-
T
---
L
--
V
A
L
G
A
I
L
M
-
L
S
-
F
A
-----
R
----
V
V
-
H
W
K
E
I
Q
K
T
A
D
------
W
G
I
L
L
L
-------
F
G
-------
G
G
L
C
------
L
S
N
V
L
K
Q
T
G
T
S
V
F
L
A
N
A
L
S
D
M
V-
S
H--
M
--
G
I
------
F
V
---
V
----
I
LV
V
-
A
T
F
-------
V
V
F
L
--------
T
E
F
T
--
S
N
--
V
A
T
T
T
L
L
I
P
V
F
A
T
V
A
E
A
-----
F
G
---
M
S
-
P
V
L
L
S
V
L
I
A
V
A
AS
C
---
A
F
M
L
P
V
A
T
--------------------
P
P
N
A
I
V
F
A
S
G
-------
H
----
I
K
Q
-
S
E
M
M
R
V
G
L
Y
L
N
I
A
C
I
G
L
L
T
A
I
A
M
L
F
W
--------------------------
25
Fugue
52.62
17%
-53
- C3 -
-
5T3B
14
?
A:
[24-481]
LPVPG
P
A
E
T
Y
P
---
N
-
S
T
K
Q
Y
Q
P
I
I
V
E
Y
A
E
K
P
D
K
A
F
--
I
E
A
K
T
R
---
I
L
----
P
Y
L
V
G
Y
E
Q
----
T
---
K
T
Q
D
E
Y
L
Q
S
V
N
K
Y
G
S
Y
A
K
G
Q
K
F
K
A
T
-
G
R
F
R
V
E
K
N
-
S
N
G
R
S
W
I
V
D
P
E
G
Y
--------------------
P
Y
Y
V
R
G
I
A
-
S
F
R
M
D
G
N
-
S
S
A
F
G
K
L
--------------
Y
S
S
V
-
D
D
W
V
----------
A
K
S
Q
K
Q
F
S
E
-----
I
G
F
H
---------
S
V
-
C
-
A
--
F
G
----------
K
-
E
-
E
G
D
-
K
--
A
--
V
--
N
-
D
--
Y
-------
N
K
S
---
A
-----
S
-----
S
P
-
L
T
Q
A
P
S
F
S
F
L
A
E
F
K
N
--
S
K
G
I
S
Y
P
G
Q
N
V
N
L
K
I
-
G
L
V
F
Y
D
G--
W
D
E
W
C
K
E
Y
L
N
S
D
A
----
F
G
-
M
F
R
N
N
P
--
D
V
----
L
G
F
F
-
S
D
--
N
E
I
D
F
-
S
T
-
W
G
N
R
L
L
D
R
F
L
K
-
I
-
S
-
N
---
K
QD
P
A
Y
I
A
A
A
K
-
F
M
T
D
K
D
KSA
N
V
S
---
D
V
-
T
D
E
L
N
N
E
F
A
G
I
C
A
E
K
Y
Y
S
A
I
K
N
-------
A
V
-------
K
A
S
K
DPELLY
L
G
S
R
L
H
S
L
P
K
Y
N
S
Y
I
I
K
A
A
G
K
--
Y
---
C
--
D
V
------
I
S
---
I
NYYS
K
--
W
S
P
E
K
-------
G
Y
M
D
--------
G
W
K
N
--
Q
A
G
G
T
P
F
M
V
T
E
F
Y
T
K
G
E
D
T
K
L
DNSSG
A
G
F
-
V
V
R
D
Q
Q
N
R
G
F
A
Y
Q
H
F
--
T
---
L
G
L
L
E
A
K
N
--------------------
C
V
G
W
V
F
F
K
Y
L
DDEDCNK
G
----
M
-
L
-
D
Y
N
Y
K
P
Y
T
S
L
T
K
Y
M
S
D
I
N
W
N
V
Y
N
L
I
D
Y
F
D
K----------------------
30
Fugue
52.50
16%
-51
- C6 -
-
4EXK
2
MALE_ECOLI
A:
[4-478]
----------------
A
K
I
E
E
G
K
L
V
I
W
I
N
G
D
K
G
Y
N
G
L
A
E
V
G
K
K
F
---
E
K
----
D
T
G
I
K
V
T
V
E
H
P
D
K
---
L
E
E
K
F
P
Q
V
A
A
T
G
D
G
-
P
D
I
I
F
W
A
H
D
R
F
G
G
Y
A
Q
S
G
L
-
L
A
E
I
T
P
A
A
A
F
Q
D
K
L
--
Y
-
P
------
F
-
T
--
W
D
A
V
R
Y
N
G
K
L
I
-
A
Y
P
I
A
-
V
-
E
A
L
S
L
I
Y
--------------
N
K
D
L
-
L
P
N
P
----------
P
K
T
W
E
E
I
P
A
-----
L
D
K
E
---------
L
K
-
A
K
G
--
K
S
A
L
-----
M
F
N
L
-
Q
-
E
P
Y
-
F
--
T
--
W
--
P
-
L
--
I
-------
A
A
D
---
G
-----
G
Y
A
F
K
Y
A
A
G
K
Y
D
I
K
D
V
G
V
D
N
A
G
A
K
--
A
G
L
T
F
L
V
D
L
I
K
N
K
H
M
-
N
A
---
D
---
T
D
Y
S
I
A
E
A
A
F
N
K
G
----
E
T
-
A
M
T
I
N
G
--
P
W
A
------
W
-
S
N
--
I
D
T
S
A
-
V
N
-
Y
G
V
T
V
L
-
P
T
F
K
-
G
-
Q
-
P
---
S
--
K
P
F
V
G
V
L
S
-
A
G
I
N
------
A
A
---
S
P
-
N
K
E
L
A
K
E
F
L
E
N
Y
L
L
T
D
E
G
L
E
A
V
-------
N
K
D
KPLGAV
A
L
K
S
------
Y
E
E
E
L
A
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
--
E
---
I
--
M
P
NIPQ
M
S
A
F
---
W
----
Y
--
A
-
V
R
T
-------
A
V
I
N
--------
A
A
S
G
RQ
T
V
--
D
A
A
L
A
A
A
Q
T
N
A
A
A
N
T
P
S
-----
P
D
L
T
V
M
S
-
I
D
K
S
V
L
S
P
G
E
S
--
A
---
T
I
T
T
I
V
K
D
IDGNPVN
E
V
H
I
N
K
T
V
A
R
ENL
K
G
L
W
D
Y
G
P
L
K
-------
K
----
E
N
V
P
G
K
Y
T
Q
V
I
T
Y
R
G
H
S
N
E
R
I
D
I
S
F
K
Y
A
M
S
F
T
K
E
I
S
I
R
G
R
LS--------------
29
Fugue
49.58
18%
-56
- C2 -
-
4RUW
2
?
A:
[53-438]
------R
R
D
L
R
---
V
M
T
W
N
I
H
T
A
V
A
P
D
A
P
G
V
V
D
E
P
R
I
A
A
V
I
R
A
E
---
A
P
----
D
V
V
V
---
L
---
N
E
----
V
H
R
D
A
P
G
P
G
-
S
H
G
D
------
Q
P
A
R
L
A
E
L
L
A
A
D
G
Y
V
H
T
W
F
G
L
T
E
V
D
L
P
H
--
E
-
G
------
A
-
V
---
L
P
G
S
S
N
G
N
V
V
M
S
R
H
P
F
-
V
-
G
G
G
V
V
V
P
--------------
L
P
N
E
N
Y
E
P
G
----------
G
K
L
R
R
S
L
L
T
-----
V
T
V
D
---------
V
P
G
L
-
G
--
D
V
V
V
--
H
A
T
H
L
S
T
-
P
-
G
S
A
-
V
--
L
--
V
--
E
-
D
--
Q
-------
K
E
Q
---
L
------
R
I
V
L
D
H
V
-
D
A
R
V
P
-
S
V
L
A
G
D
L
N
I
--
W
T
T
D
V
P
T
Q
P
Y
S
Q
N
N
L
M
Q
S
W
I
A
E
D
HL
A
D
T
W
R
Q
V
N
D
P
G
A
G
----
P
T
M
T
A
S
Y
G
R
--
P
E
S
P
H
P
D
R
R
--
I
D
--
Y
V
F
A
T
-
P
A
-
F
D
V
V
A
G
-
H
V
S
L
-
V
-
D
-
R
---
F
--
A
S
D
H
L
G
V
V
M
D
L
R
L
G
G
-------------------------
A
P
V
A
A
R
T
V
L
-------
A
G
-------
E
D
G
L
------
D
G
W
A
Q
L
T
A
S
R
P
G
R
L
R
L
S
V
C
K
N
--
R
---
G
--
Q
A
------
D
D
---
D
----
G
--
T
-
A
V
R
-------
A
V
L
R
--------
N
R
A
G
-----------------------------------------------------
V
A
L
R
T
V
T
D
--------------------
S
G
T
S
-
R
D
R
C
T
-------
V
----
E
T
W
-
R
G
A
L
P
P
G
A
R
L
E
A
C
L
V
G
A
D
G
T
I
L
A
S
R
T
E
T
L
-----------------------
26
Fugue
48.27
19%
-27
* C4 *
-
3RFY
-
CYP38_ARATH
A:
[78-433]
------G
G
I
L
L
---
V
-
A
N
P
V
I
P
D
V
S
V
L
I
S
G
P
P
I
K
D
P
E
A
L
L
R
Y
A
L
---
P
I
DN
K
A
I
R
E
V
Q
K
P
L
---
E
D
---
I
T
D
S
L
K
I
A
G
V
K
A
L
D
S
V
E
R
N
V
R
Q
A
S
R
T
L
Q
---------
Q
G
K
S
I
I
V
A
G
F
A
E
--
S
-
K
------
K
-
D
--
H
G
N
E
M
I
E
K
L
E
A
-
G
M
Q
D
M
-
L
-
K
---------------------------
I
V
----------
E
D
R
K
R
D
------------------------------------
A
V
A
P
K
Q
-
K
-
E
I
L
-
K
--
Y
--
V
--
G
-
G
--
I
-------
E
E
D
---
M
-----
V
D
G
F
P
Y
E
-----
V
P
E
E
Y
R
N
M
P
L
L
K
G
R
A
S
V
D
M
K
V
K
I
K
D
N
----------------------
P
N
I
E
----
D
C
-
V
F
R
I
V
L
D
G
Y
N
A
P
V
T
A
G
N
F
-
V
D
--
L
V
E
R
------------
H
F
Y
D
-
G
-
M
-
E
---
I
--
Q
R
S
D
G
F
V
V
-
Q
T
---
G
---
D
P
E
---
G
P
-
A
E
G
F
I
D
P
S
T
E
K
T
R
T
V
P
L
E
I
M
V
T
-------
G
E
-------
K
T
P
F
------
Y
G
S
T
L
E
E
L
G
L
Y
K
A
Q
V
V
I
P
F
N
A
--
F
---
G
--
T
M
------
A
M
---
A
----
R
--------------
E
E
F
E
--------
N
D
S
G
--
S
S
--
Q
V
F
W
L
L
K
E
S
E
L
T
P
--------------
S
N
-
S
N
I
L
----
D
G
R
--
Y
---
A
V
F
G
Y
V
T
D
--------------------
N
E
D
F
L
A
D
---------------
L
K
V
-
G
D
V
I
E
S
I
Q
V
V
S
G
L
E
N
L
A
N
P
S
Y
-------------------------------
39
HHSearch
44.95
13%
-179
- C3 -
-
5ULD
1
?
C:
[295-439]
-----------------------------------------------------------------------
K
E
I
Q
K
T
A
D
W
---
G
I
L
L
L
F
G
G
G
L
C
L
S
N
V
L
K
Q
T
G
-
T
S
V
F
L
A
N
A
L
S
D
M
V
S
--
H
-
M
G-----
I
-
F
VV
I
L
V
V
A
T
F
V
V
F
L
-
T
E
F
T
S
-
N
-
V
A
T
T
T
L
L
--------------
I
P
V
F
-
A
T
V
A
----------
E
A
F
G
M
S
P
V
L
-----
L
S
V
L
---------
I
A
-
V
-
A
--
A
S
C
A
---
F
M
L
P
V
A
-
T
P
P
N
A
-
I
--
V
--
F
--
A
-
S
--
G
-------
H
I
K
---
Q
-----
S
E
M
M
R
V
G
L
-
Y
L
N
I
A
C
I
G
L
-
L
T
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
43.38
13%
-175
- C3 -
-
5ULE
1
?
C:
[295-439]
-----------------------------------------------------------------------
K
E
I
Q
K
T
A
D
W
---
G
I
L
L
L
F
G
G
G
L
C
L
S
N
V
L
K
Q
T
G
-
T
S
V
F
L
A
N
A
L
S
D
M
V
S
--
H
-
M
G-----
I
-
F
VV
I
L
V
V
A
T
F
V
V
F
L
-
T
E
F
T
S
-
N
-
V
A
T
T
T
L
L
--------------
I
P
V
F
-
A
T
V
A
----------
E
A
F
G
M
S
P
V
L
-----
L
S
V
L
---------
I
A
-
V
-
A
--
A
S
C
A
---
F
M
L
P
V
A
-
T
P
P
N
A
-
I
--
V
--
F
--
A
-
S
--
G
-------
H
I
K
---
Q
-----
S
E
M
M
R
V
G
L
-
Y
L
N
I
A
C
I
G
L
-
L
T
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
36.81
25%
-64
* C5 *
-
2EJV
1
TDH_THET8
A:
[114-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
D
R
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
--
W
---
V
--
N
P
------
K
D
---
L
----
P
--
F
-
E
V
A
-------
A
I
L
E
P
F
G
N
A
V
H
T
V
Y
A
G
--
S
G
--
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
-----
A
A
M
-
V
V
R
-------
A
S
G
A
G
--
P
---
I
L
V
S
D
P
N
P
--------------------
Y
R
L
A
F
A
R
P
Y
A
-------
D
----
R
L
V
-
N
P
L
E
E
--
D
L
L
E
V
V
R
R
V
T
G
S
G
V
E
V
L
L
E
--------------------------
8
PsiBlast_PDB
36.44
25%
-64
- C5 -
-
2DQ4
1
TDH_THET8
A:
[114-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
D
R
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
--
W
---
V
--
N
P
------
K
D
---
L
----
P
--
F
-
E
V
A
-------
A
I
L
E
P
F
G
N
A
V
H
T
V
Y
A
G
--
S
G
--
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
-----
A
A
M
-
V
V
R
-------
A
S
G
A
G
--
P
---
I
L
V
S
D
P
N
P
--------------------
Y
R
L
A
F
A
R
P
Y
A
-------
D
----
R
L
V
-
N
P
L
E
E
--
D
L
L
E
V
V
R
R
V
T
G
S
G
V
E
V
L
L
E
--------------------------
41
HHSearch
33.69
13%
-137
* C3 *
-
4R0C
-
?
D:
[326-475]
------------------------------------------------------------------------
A
M
E
V
T
M
A
S
-
M
A
G
Y
L
V
L
M
F
F
A
A
Q
F
V
A
W
F
N
Y
S
Q
-
L
G
L
L
L
A
V
K
G
A
A
W
L
G
A
L
T
V
P
------
K
-
V
V
L
L
L
L
F
V
V
L
T
A
L
I
-
N
L
M
I
G
-
S
A
S
A
K
W
S
I
L
--------------
A
P
V
F
-
I
P
M
L
----------
M
L
L
G
I
S
P
E
A
-----
S
Q
A
A
---------
Y
R
-
V
-
G
--
D
S
S
T
--
N
I
I
T
P
L
M
-
P
-
Y
F
V
L
V
--
L
--
G
F
A
R
-
R
Y
Q
P
-------
E
T
G
---
I
-----
G
T
L
I
A
L
M
L
-
P
Y
S
L
T
L
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
32.85
13%
-141
- C3 -
-
4R0C
-
?
C:
[326-475]
------------------------------------------------------------------------
A
M
E
V
T
M
A
S
-
M
A
G
Y
L
V
L
M
F
F
A
A
Q
F
V
A
W
F
N
Y
S
Q
-
L
G
L
L
L
A
V
K
G
A
A
W
L
G
A
L
T
V
P
------
K
-
V
V
L
L
L
L
F
V
V
L
T
A
L
I
-
N
L
M
I
G
-
S
A
S
A
K
W
S
I
L
--------------
A
P
V
F
-
I
P
M
L
----------
M
L
L
G
I
S
P
E
A
-----
S
Q
A
A
---------
Y
R
-
V
-
G
--
D
S
S
T
--
N
I
I
T
P
L
M
-
P
-
Y
F
V
L
V
--
L
--
G
F
A
R
-
R
YQ
P
-------
E
T
G
---
I
-----
G
T
L
I
A
L
M
L
-
P
Y
S
L
T
L
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
31.29
22%
-119
- C5 -
-
4YSN
1
ILE2E_LACBU
A:
[220-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
-----
G
G
I
-
I
K
A
-
P
E
E
Y
M
--------
Q
---
L
V
Y
K
F
C
H
E
--------------------
H
G
I
L
F
A
I
D
E
V
-------
N
----
Q
G
L
-
G
R
T
G
K
M
W
A
I
Q
Q
-----------------------------------------
12
PsiBlast_PDB
30.39
24%
-161
- C5 -
-
4MT1
-
?
A:
[933-1040]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
-
F
-
Q
V
G
F
V
T
V
--------------
M
G
L
S
-
A
K
N
A
I
L
I
I
E
F
A
K
D
L
Q
A
Q
G
K
S
A
V
E
-----
A
A
L
E
A
A
R
L
R
F
R
P
I
I
M
-
T
-
S
--
F
A
F
I
--
L
G
V
V
P
L
Y
-
I
-
A
A
G
----
A
--
S
--
S
-
A
--
S
-------
Q
R
A
---
I
-----
G
T
T
V
F
W
G
M
-
L
V
G
T
L
L
S
V
F
L
V
P
L
F
Y
--
V
V
V
R
K
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------