@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKU1: (2017-10-29 )
MTTIIKQDDLITSIKDALQFISYYHPQDFIQAMSRAYDREENKAAKDAIAQILINSRMCAEGHRPICQDTGIVNVFLEVGLDVKFDLTMSLDDAVNEGVRQGYLENSNVLRASVLADPAFGRKNTKDNTPAVIHYKLVPGNKVDITVAAKGGGSENKSKLAMLNPSDSIVDWVLKTVPTMGAGWCPPGMLGIGIGGTAEKAMMLAKEALMEEINMDELLRRGPENKIEELRIEIFEKVNALGIGAQGLGGLTTVLDIKIKDYPCHAAGKPVGMIPNCAATRHAHFQLDGSGVAHIQAPKLEDYPSVTWDASQSKRVNLDTITQEEMDSWKPGDTLLLSGTMYTGRDAAHKRMVEMIDNGEELPVDLKGKFIYYVGPVDPVRDEVVGPAGPTTATRMDKFTRKVLEHTGLFGMIGKADRGPTAIEAIKDNKATYLMAVGGAAYLVSKAVREAEVVAFADLGMEAIYKFVVEDMPVSVAVDVNGTSIHAVAPKIWQAKIGKIPVIDAAAG
Atome Classification :
(20 SA)
--------------------------------------........---.10......-----..20--........30.-.....-.---------.40--...--.....50........60..-.--------------------.....70.....---...-80........90--....-.....100.......----110.......-120.....---..130.---....-..140.......150----...-----......160---.--.....----.----..170---.......180.......190.....-.-.200.......210...-----.-----...220--....----....230.......240.......250.......260.......270.......280.......290....-----...300..--.....310-...---.....320-..--.......330.......------340..--.....350.....-------..360-.......370.-----....-..380-...-....-.390.......400.......410......------------.420.......430.......-440..--.-.-...450......-.460........470-.----------......480.......490.......500-.......------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------MTTIIK
Q
D
---
D
L
I
T
S
I
K
D
A
-----
L
Q
F
I
--
S
YY
H
P
Q
D
F
I
Q
A
-
M
S
R
AY-D---------REE--N
K
A
--
A
K
D
A
I
A
Q
I
L
INSRMCAEGH-R--------------------PICQDT
G
I
V
N
V
F
---
L
EV-G
L
D
V
K
F
D
L
T
MS---
L
D
D
A
-
V
N
E
G
V
R
QGYLENSN
V
----
L
R
A
S
VLADPA-FGRKNTKD---NT
P
A
V
I
---
H
Y
K
L-VPG
N
K
V
D
I
T
V
A
AK------GGG-----SENK
S
K
L
-----
A
--
M
LNP
S
----
D
----
S
I
V
D
W
---
V
L
K
TVPTMGAGWCPPG
M
L
G
IGIGG
T
-
A
-
E
K
A
M
M
L
A
K
E
A
L
M
E
EI
N
M
-----
D
-----
E
L
L
R
R---GPE
N
----
K
I
E
E
L
R
I
E
I
F
E
K
V
N
ALGIGAQGLGG
L
T
T
V
L
D
I
K
I
KDYPCHAAGKPVGMIPNCAAT
R
H
A
H
F
Q
LDGS
G
V
A
H
IQ-----APKLEDYP--S
V
T
WDAS--QSK---RVN
L
D
T---I
T
--
Q
E
E
M
DSWKPG
D
T
L
L
L
SG------TMYTG--
R
D
A
A
H
K
R
M
V
E
M
ID-------NGEEL-PVDLK
G
K
F
I
Y
Y
-----VGPV-DP
V
R
--
D
EV-VGPA-GP
T
T
A
T
R
M
D
K
F
T
R
K
V
L
E
HTGLFGMIGKADR------------GP
T
A
I
E
AIKDNK
A
T
Y
L
M
AVG
G
-
A
A
Y
L
V
--
S
-
K
-
A
V
R
E
A
E
V
V
A
F
A
D
-
L
G
M
-
E
A
I
Y
K
F
V
V
EDM-P----------
V
S
V
A
V
D
VNG
T
S
I
H
AVA
P
K
I
W
Q
AKIGKI
P
--
V
IDAAAG------
1
PsiBlast_PDB
73.94
30%
-2
- C5 -
-
5L2R
13
?
A:
[118-600]
---------------------------------------------------------
A
-----
F
S
D
V
--
H
H
F
F
R
K
D
H
L
E
G
-
W
R
R
A
I
-
E
---------
D
P
E
--
A
S
D
--
N
D
R
Y
V
A
T
T
L
L
K
N
A
C
I
A
A
G
R
V
L
--------------------
P
S
C
Q
D
T
G
T
A
I
V
L
---
G
K
R
-
G
---
E
L
C
W
T
G
G
---
E
D
E
K
Y
L
S
K
G
I
W
N
A
Y
-
R
Y
H
N
L
----
R
Y
S
Q
T
A
A
L
D
M
-
F
K
E
C
N
T
G
D
---
N
L
P
A
Q
L
---
D
L
L
A
-
V
P
G
S
D
Y
E
F
L
F
I
A
K
------
G
G
G
-----
S
A
N
K
A
Y
L
Y
QETK
A
--
L
L
N
P
K
---------
S
L
R
A
F
---
I
E
E
K
L
K
T
L
G
T
A
A
C
P
P
Y
H
I
A
L
V
I
G
G
T
S
A
-
E
M
T
M
K
T
V
K
L
A
S
C
R
Y
Y
D
S
LPTTG
D
-----
K
Y
G
R
A
---
F
R
D
P
----
E
W
E
K
I
V
M
E
V
A
Q
K
S
---
G
I
G
A
Q
-
F
G
G
K
Y
F
A
H
Q
A
R
V
I
R
L
P
R
H
G
A
S
C
P
V
G
L
A
V
S
C
S
A
D
R
Q
I
L
A
H
I
N
K
S
G
I
Y
I
E
Q
L
EQNP
A
Q
Y
L
P
-----------
T
--
S
V
K
V
D
L
K
R
P
I
D
K
---
V
R
--
Q
Q
-
L
S
Q
Y
P
V
G
T
R
V
M
L
N
G
------
T
L
I
V
A
--
R
D
I
A
H
A
K
I
K
E
M
M
D
-------
N
G
E
P
L
-
P
E
Y
M
K
T
S
P
I
Y
Y
-----
A
G
P
A
-
K
T
P
E
--
G
Y
A
-
S
G
S
F
-
G
P
T
T
A
G
R
M
D
S
Y
V
D
L
F
Q
S
H
G
G
S
Y
I
T
L
A
K
G
N
R
------------
S
K
Q
V
T
D
A
C
K
K
H
G
G
F
Y
L
G
S
I
G
G
-
P
A
A
I
L
--
A
-
K
D
S
I
K
Q
V
T
C
L
A
F
P
E
-
L
G
M
-
E
A
V
W
K
I
E
V
E
D
F
-
P
----------
A
F
I
V
V
D
D
K
G
N
D
M
Y
S
-----------------------------
5
HHSearch
71.03
29%
5
- C5 -
-
5L2R
13
?
A:
[105-603]
-----------------------------------------
K
V
N
P
E
---
A
L
T
I
L
A
H
R
A
-----
F
S
D
V
--
H
H
F
F
R
K
D
H
L
E
G
-
W
R
R
A
I
-
E
---------
D
P
E
A-
S
D
N
--
D
R
Y
V
A
T
T
L
L
K
N
A
C
I
A
A
G
R
V
-
L
--------------------
P
S
C
Q
D
T
G
T
A
I
V
L
---
G
K
R
-
G
E
L
C
-
W
T
G
-
G
E
---
D
E
K
Y
-
L
S
K
G
I
W
N
A
Y
R
--
Y
H
N
----
L
R
Y
S
Q
T
A
A
L
D
M
F
K
E
C
N
T
G
D
---
N
L
P
A
Q
L
---
D
L
L
A
-
V
P
G
S
D
Y
E
F
L
F
I
A
K
------
G
G
G
-----
S
A
N
K
A
Y
L
-----
Y
--
Q
E
T
K
A
----
L
LN
P
K
S
L
R
A
F
---
I
E
E
K
L
K
T
L
G
T
A
A
C
P
P
Y
H
I
A
L
V
I
G
G
T
-
S
A
E
M
T
M
K
T
V
K
L
A
S
C
R
Y
Y
D
S
-----
L
PTTGD
K
Y
G
R
A
---
F
R
D
P
-------
E
W
E
K
I
V
M
E
V
A
Q
K
S
G
I
G
A
Q
-
F
G
G
K
Y
F
A
H
Q
A
R
V
I
R
L
P
R
H
G
A
S
C
P
V
G
L
A
V
S
C
S
A
D
R
Q
I
L
A
H
I
N
K
S
G
I
Y
-
I
E
-------
Q
L
E
Q
N
P
AQ
Y
L
P
----T
S
V
K
V
---
D
L
K
R
-
P
---
I
D
K
V
R
Q
Q
L
S
Q
Y
P
V
G
T
R
V
M
L
N
G
------
T
L
I
V
A
--
R
D
I
A
H
A
K
I
K
E
M
M
D
-------
N
G
E
P
L
-
P
E
Y
M
K
T
S
P
I
Y
Y
-----
A
G
P
A
-
K
T
P
E
--
G
Y
A
-
S
G
S
F
-
G
P
T
T
A
G
R
M
D
S
Y
V
D
L
F
Q
S
H
G
G
S
Y
I
T
L
A
K
G
N
R
------------
S
K
Q
V
T
D
A
C
K
K
H
G
G
F
Y
L
G
S
I
G
G
-
P
A
A
I
L
--
A
K
D
-
S
I
K
Q
V
T
C
L
A
F
P
E
-
L
G
M
-
E
A
V
W
K
I
E
V
E
D
F
-
P
----------
A
F
I
V
V
D
D
K
G
N
D
M
Y
S
K
T
L
--------------------------
23
Fugue
70.27
29%
28
- C5 -
-
5L2R
14
?
A:
[64-604]
D
F
H
F
S
A
IFQPTDPHHHQ
T
E
F
A
K
VEGSEKY
V
E
E
V
E
V
FG
R
Q
A
L
K
V
N
P
E
---
A
L
T
I
L
A
H
R
A
-----
F
S
D
V
--
H
H
F
F
R
K
D
H
L
E
G
-
W
R
R
A
I
E
D
---------
P
E
A
--
S
D
N
--
D
R
Y
V
A
T
T
L
L
K
N
A
C
I
A
A
G
R
V
-
L
--------------------
P
S
C
Q
D
T
G
T
A
I
V
L
---
G
K
R
-
G
-----
E
L
C
W
T
GGE
D
E
K
Y
-
L
S
K
G
I
W
N
A
Y
R
Y
H
-
N
L
----
R
Y
S
Q
T
A
A
L
D
M
-
F
K
E
C
N
T
G
D
---
N
L
P
A
Q
L
---
D
L
L
A
-
V
P
G
S
D
Y
E
F
L
F
I
A
K
------
G
G
G
-----
S
A
N
K
A
Y
L
-----
Y
--
Q
E
T
K
A
LLN
P
K
----
S
L
R
A
F
---
I
E
E
K
L
K
T
L
G
T
A
A
C
P
P
Y
H
I
A
L
V
I
G
G
T
-
S
-
A
E
M
T
M
K
T
V
K
L
A
S
C
R
Y
-
Y
-----
D
-----
S
L
P
T
T
---
G
D
K
Y
G
R
A
F
R
D
P
E
W
E
K
I
V
M
E
V
A
Q
K
S
G
I
G
A
Q
-
F
G
G
K
Y
F
A
H
Q
A
R
V
I
R
L
P
R
H
G
A
S
C
P
V
G
L
A
V
S
C
S
A
D
R
Q
I
L
A
H
I
N
K
S
G
---
I
Y
-----
I
E
Q
L
E
Q
N
P
--
A
Q
Y
L
--
P
--
T
S
V
---
K
V
D
L
K
R
P
I
D
K
V
--
R
Q
Q
L
S
Q
Y
P
V
G
T
R
V
M
L
N
G
------
T
L
I
V
A
--
R
D
I
A
H
A
K
I
K
E
M
M
D
-------
N
G
E
P
L
-
P
E
Y
M
K
T
S
P
I
Y
Y
-----
A
G
P
A
-
K
T
P
E
--
G
Y
A
-
S
G
S
F
-
G
P
T
T
A
G
R
M
D
S
Y
V
D
L
F
Q
S
H
G
G
S
Y
I
T
L
A
K
G
N
R
------------
S
K
Q
V
T
D
A
C
K
K
H
G
G
F
Y
L
G
S
I
G
G
P
A
A
I
L
A
--
K
-
D
-
S
I
K
Q
V
T
C
L
A
F
P
E
-
L
G
M
-
E
A
V
W
K
I
E
V
E
D
F
-
P
----------
A
F
I
V
V
D
D
K
G
N
D
M
Y
S
K
T
L
A
-------------------------
6
HHSearch
50.62
34%
-67
- C- -
-
2ISB
-
?
A:
[5-180]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
---
E
L
R
T
-
P
---
L
V
--
K
D
Q
I
L
K
L
K
V
G
D
V
V
Y
I
T
G
------
E
I
F
T
A
--
R
D
E
A
H
A
R
A
L
E
W
M
E
-------
E
G
K
E
L
-
P
F
S
F
D
K
G
V
V
Y
H
-----
C
G
P
L
-
V
K
K
N
D-
E
W
R
-
V
V
S
A
-
G
P
T
T
S
A
R
M
N
P
F
T
P
K
I
L
E
K
V
E
C
M
G
I
I
G
K
G
G
M
------------
S
E
E
V
V
E
A
M
R
-
G
K
A
A
Y
F
A
F
T
G
G
-
A
G
A
L
A
--
A
-
M
-
S
I
K
K
V
K
G
V
V
W
E
D
-
L
G
M
P
E
A
V
W
L
L
E
V
E
R
F
G
P
----------
C
I
V
A
I
D
A
H
G
N
S
L
Y
R
R
----------------------------
3
PsiBlast_PDB
50.21
34%
-66
- C- -
-
2ISB
-
?
A:
[11-178]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
--
K
D
Q
I
L
K
L
K
V
G
D
V
V
Y
I
T
G
------
E
I
F
T
A
--
R
D
E
A
H
A
R
A
L
E
W
M
E
-------
E
G
K
E
L
-
P
F
S
F
D
K
G
V
V
Y
H
-----
C
G
P
L
-
V
K
K
N
--
D
E
W
R
V
V
S
A
-
G
P
T
T
S
A
R
M
N
P
F
T
P
K
I
L
E
K
V
E
C
M
G
I
I
G
K
G
G
M
------------
S
E
E
V
V
E
A
M
R
-
G
K
A
A
Y
F
A
F
T
G
G
-
A
G
A
L
A
--
A
-
M
-
S
I
K
K
V
K
G
V
V
W
E
D
-
L
G
M
P
E
A
V
W
L
L
E
V
E
R
F
G
P
----------
C
I
V
A
I
D
A
H
G
N
S
L
Y
------------------------------
2
PsiBlast_PDB
45.68
34%
-18
- C5 -
-
5DNI
5
TTDB_METJA
A:
[5-178]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
K
---
L
T
--
K
K
D
V
K
K
L
K
V
G
D
I
V
Y
L
N
G
------
K
I
Y
T
A
--
R
D
E
A
H
L
K
I
I
E
M
L
K
-------
S
N
E
K
L
-
P
F
D
L
N
E
S
I
I
Y
H
-----
A
G
P
I
M
K
K
V
N
--
D
S
W
-
V
C
V
S
I
G
P
T
T
S
A
R
M
N
D
V
E
E
E
F
I
K
L
T
N
I
S
A
I
V
G
K
G
G
M
------------
K
K
E
L
L
K
T
F
E
D
Y
G
V
V
Y
L
A
A
P
G
G
-
C
A
A
L
L
--
A
-
N
-
S
V
K
R
V
D
N
V
Y
F
L
D
E
L
G
M
P
E
A
V
W
E
L
E
V
N
N
F
G
P
----------
L
I
V
A
M
D
S
H
G
N
S
I
Y
------------------------------
7
HHSearch
45.62
34%
-19
- C5 -
-
5DNI
6
TTDB_METJA
B:
[3-179]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
F
N
K
---
L
T
--
K
K
D
V
K
K
L
K
V
G
D
I
V
Y
L
N
G
------
K
I
Y
T
A
--
R
D
E
A
H
L
K
I
I
E
M
L
K
-------
S
N
E
K
L
-
P
F
D
L
N
E
S
I
I
Y
H
-----
A
G
P
I
-
M
K
K
V
ND
S
W
V
-
C
V
S
I
-
G
P
T
T
S
A
R
M
N
D
V
E
E
E
F
I
K
L
T
N
I
S
A
I
V
G
K
G
G
M
------------
K
K
E
L
L
K
T
F
E
D
Y
G
V
V
Y
L
A
A
P
G
G
-
C
A
A
L
L
--
A
-
N
-
S
V
K
R
V
D
N
V
Y
F
L
D
E
L
G
M
P
E
A
V
W
E
L
E
V
N
N
F
G
P
----------
L
I
V
A
M
D
S
H
G
N
S
I
Y
E
-----------------------------
4
PsiBlast_CBE
44.19
34%
-12
- C5 -
-
5DNI
6
TTDB_METJA
B:
[5-178]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
K
---
L
T
--
K
K
D
V
K
K
L
K
V
G
D
I
V
Y
L
N
G
------
K
I
Y
T
A
--
R
D
E
A
H
L
K
I
I
E
M
L
K
-------
S
N
E
K
L
-
P
F
D
L
N
E
S
I
I
Y
H
-----
A
G
P
I
M
K
K
V
N
--
D
S
W
-
V
C
V
S
I
G
P
T
T
S
A
R
M
N
D
V
E
E
E
F
I
K
L
T
N
I
S
A
I
V
G
K
G
G
M
------------
K
K
E
L
L
K
T
F
E
D
Y
G
V
V
Y
L
A
A
P
G
G
-
C
A
A
L
L
--
A
-
N
-
S
V
K
R
V
D
N
V
Y
F
L
D
E
L
G
M
P
E
A
V
W
E
L
E
V
N
N
F
G
P
----------
L
I
V
A
M
D
S
H
G
N
S
I
Y
------------------------------
17
HHSearch
41.19
20%
-146
- C7 -
-
4YX5
-
A:
[20-39]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
T
Q
--
R
S
L
L
G
R
I
G
I
G
D
V
L
L
I
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
36.59
20%
17
- C5 -
-
4CI0
1
?
A:
[2-386]
---------------------------------S
E
R
I
V
I
S
P
T
S
R
Q
E
G
H
A
E
L
V
M
E
V
D
D
E
GIVT
K
G
R
Y
F
--
S
I
T
P
V
R
G
L
E
K
M
-
V
T
-------------------
G
K
A
--
P
E
T
A
P
V
M
V
Q
--------------------------------
R
I
C
G
V
C
P
I
P
H
T
L
---
A
S
V
E
A
I
D
D
S
L
D
I
E
V
P
------------------
K
A
G
R
L
----
L
R
E
L
T
L
A
A
H
H
-
V
----------
N
S
H
A
I
H
---
H
F
L
I
-
A
P
D
F
-----
V
P
E
N
------
L
M
A
-----
D
A
I
N
S
V
S
-----
E
--
I
R
K
N
A
----
Q
----
Y
V
V
D
M
---
V
A
------
G
E
G
I
H
P
S
D
---
V
R
I
G
G
M
-
A
-
D
--------------
N
I
-----
T
-----
E
L
A
R
K
---
R
L
Y
A
----
R
L
K
Q
L
K
P
K
V
N
E
H
V
E
L
M
I
G
L
I
E
D
K
G
L
-------------------
P
E
G
L
G
V
H
N
Q
P
T
L
A
S
H
-
Q
I
Y
G
D
-------------------------------
R
T
---
K
F
D
L
D
R
---
F
T
--
E
I
M
P
E
S
W
------------------
Y
D
D
--
P
E
I
A
K
R
A
C
S
T
I
P
L
Y
------
D
G
R
N
V
-
E
V
G
P
R
A
R
M
V
E
F
-----
Q
G
F
-----
K
--
E
R
G
-
V
V
A
Q
-
H
V
A
R
A
L
E
M
K
T
A
L
S
R
A
I
E
I
L
D
E
L
D
T
-------------------
S
A
P
V
R
A
D
F
D
E
R
G
T
G
K
L
G
I
G
A
-
I
E
A
P
R
--
G
-
L
-
D
V
H
M
A
K
V
E
---
N
-
G
K
I
-
Q
F
Y
S
A
L
V
P
T
T
W
-
N
----------
I
P
T
M
G
P
A
T
E
G
F
H
H
E
Y
G
P
H
V
I
R
A
Y
D
---
P
--
C
L
S
C
A
T
H
------
26
Fugue
35.32
17%
-51
- C2 -
-
4IKW
13
?
A:
[3-494]
-----------------------------------------
S
I
D
K
Q
---
Q
I
A
A
S
V
P
Q
R
-----
G
F
F
-----
G
H
P
K
G
L
F
T
L
-
F
F
T
E
F
-
W
---------
E
R
F
--
S
Y
Y
--
G
M
R
A
I
L
V
Y
Y
M
Y
Y
E
V
S
K
G
G
-------------------------------------------------
L
G
L
D
---
E
H
L
A
-
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
----
I
I
G
G
W
L
A
D
R
V
-
F
G
T
S
R
A
V
F
---
Y
G
G
L
L
I
M
A
G
H
I
A
L
A
I
P
G
G
V
A
A
L
F
V
S
M
A
L
I
V
L
G
T
G
L
L
-----
K
P
N
V
S
S
I
-----
V
G
D
M
Y
K
P
G
----
D
----
D
R
R
D
A
G
F
S
I
F
Y
M
G
I
N
L
G
A
F
L
A
P
L
V
V
G
T
A
G
M
K
Y
N
-
F
-
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
-----
F
-----
V
A
T
R
K
KNL
G
L
A
G
----
T
Y
V
P
N
P
L
T
P
A
E
K
K
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
W
------------
F
T
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
-----
F
V
V
M
Y
R
S
P
--
K
T
T
----------------------
A
--
E
E
R
S
R
V
I
A
Y
I
P
L
F
V
A
S
A
------
M
F
W
A
I
--
Q
E
Q
G
S
T
I
L
A
N
Y
A
D
KRTQLDV
A
G
I
H
L
S
P
A
W
F
Q
S
L
N
P
L
F
-----
I
I
I
L
-
A
P
V
F
--
A
W
M
-
W
V
K
L
-
G
K
R
Q
P
T
I
P
Q
K
F
A
L
G
L
L
F
A
G
L
S
F
I
V
I
L
V
P
G
H
L
S
GGGLVHP
I
W
L
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
-
T
T
K
L
A
PA
A
-
F
-
S
A
Q
T
M
S
L
W
F
L
S
N
-
A
A
A
-
Q
A
I
N
A
Q
L
V
R
F
Y
-
T
PENETA
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
L
A
I
A
P
R
I
G
R
L
M
K
G
------------------
31
Fugue
33.91
13%
27
- C6 -
-
4U1C
-
EIF3C_YEAST
C:
[251-794]
-----------------------QEDFFTRLQTIIDSR
G
K
K
T
V
N
Q
Q
---
S
L
I
S
T
L
E
E
L
-----
L
T
V
A
EK
P
Y
E
F
I
M
A
Y
L
T
L
-
I
P
S
R
F
-
D
ASANLSYQP
I
D
Q
--
W
K
S
--
S
F
N
D
I
S
K
L
L
S
I
L
D
Q
T
I
D
T
Y
-
Q
VNEFADPIDFIEDEPKEDSD
G
V
K
R
I
L
G
S
I
F
S
F
---
V
E
R
--
L
D
D
E
F
M
K
S
L
L
---
N
I
D
P
-
H
S
S
D
Y
L
I
R
L
R
D
E
Q
S
I
YNLI
L
R
T
Q
L
Y
F
E
A
T
-
L
K
D
E
H
D
L
E
RAL
T
R
P
F
V
K
---
R
L
D
H
-
I
Y
Y
K
S
E
N
L
I
K
I
M
E
------
T
A
A
WNIIP
A
Q
F
K
S
K
F
-----
T
--
S
K
D
Q
L
----
D
----
S
----------------
A
D
Y
V
D
N
L
I
D
G
L
S
T
I
L
S
-
K
-
Q
N
N
I
A
V
Q
K
R
A
I
L
Y
N
I
Y
Y
-----
T
-----
A
L
N
K
D
---
F
Q
T
A
----
K
D
M
L
L
T
S
Q
V
Q
T
N
I
N
Q
F
D
S
S
L
Q
I
L
F
N
R
V
V
V
-
Q
L
G
L
S
A
F
K
L
C
L
I
E
E
C
H
Q
I
L
N
D
L
L
S
S
S
H
L
R
E
I
L
G
Q
Q
S
L
H
R
I
S
-----
L
N
S
S
N
---------
N
A
S
--
A
D
E
---
R
A
R
-
Q
C
---
L
P
--
Y
H
Q
H
I
N
L
D
L
I
D
V
V
F
L
T
C
------
S
L
L
I
E
IP
R
M
T
A
F
Y
S
G
I
K
-
V
K
-------
R
I
P
Y
S
-
P
K
S
I
R
R
S
L
E
H
Y
DKLSF
Q
G
P
P
-
E
T
L
R
--
D
Y
V
-
L
F
A
A
-
K
S
M
Q
K
G
N
W
R
D
S
V
K
Y
L
R
E
I
K
S
W
A
L
L
P
N
M
E
T
V
------------
L
N
S
L
T
E
R
V
Q
V
E
S
L
K
T
Y
F
F
S
F
K
-
R
F
Y
S
S
--
F
-
S
-
V
A
K
L
A
E
L
F
D
L
P
E
-
N
K
V
-
V
E
V
L
Q
S
V
I
A
E
L
-
E
----------
I
P
A
K
L
N
D
E
K
T
I
F
V
V
-------
E
K
G
D
E
I
T
--
K
L
E
E
A
M
V
KL----
32
Fugue
29.14
18%
-28
- C4 -
-
5IH3
7
CARM1_MOUSE
A:
[10-352]
----------------------------------------
S
V
F
S
E
R
------
T
E
E
S
S
A
-----
V
Q
Y
F
--
Q
F
Y
G
Y
L
S
Q
Q
Q
N
-
M
M
Q
---
D
---------
Y
V
R
--
T
G
T
--
Y
Q
R
A
I
L
Q
-----------
N
-
H
--------------------
T
D
F
K
D
K
I
V
L
D
V
G
---
C
G
S
-
G
I
L
S
F
F
A
A
Q
A
------------
G
A
R
K
I
Y
A
V
E
---------
A
S
T
M
A
Q
H
A
-
E
V
L
V
K
S
N
N
---
L
T
D
------
R
I
V
V
-
I
P
G
K
V
E
E
V
S
L
P
---------------------------------
E
Q
V
----
D
----
I
I
I
S
E
----------------
P
M
G
Y
M
L
F
N
--
E
R
-
M
-
L
E
S
Y
L
H
A
K
K
Y
L
K
P
S
G
N
M
FP---
T
-----
I
G
D
V
H
---
L
A
P
F
----
T
D
E
Q
L
Y
M
E
Q
F
T
K
A
N
F
W
Y
--
Q
P
S
F
H
G
V
D
L
-------------------------------
S
A
L
R
G
A
A
V
D
E
Y
F
-----
R
Q
P
V
V
D
T
F
--
D
I
R
I
L
M
A
--
K
S
V
---
K
Y
T
V
N
F
---
L
E
--
A
K
E
G
D
L
H
R
I
E
I
P
F
K
F
H
------------------------
M
L
H
-------
S
G
L
V
H
------
G
L
A
F
W
F
-----
D
V
A
F
-
I
G
S
I
--
M
T
V
-
W
L
S
T
-
A
P
T
E
P
L
T
H
W
Y
Q
V
R
C
L
F
Q
S
P
-
L
F
A
K
A
G
D
T
L
S
------------
G
T
C
L
L
I
A
N
K
R
Q
------------
S
Y
D
I
--
S
-
I
-
V
A
Q
V
D
Q
T
--------------------------------------
G
S
K
S
S
N
L
L
D
L
K
N
P
F
F
R
Y
T
--------------------
25
Fugue
28.68
29%
-74
* C5 *
-
1ZXA
-
KGP1_HUMAN
A:
[9-44]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
I
L
M
L
K
E
E
R
I
-----
K
-----
E
L
E
K
R
L
S
-
E
K
E
E
----
E
I
Q
E
L
K
R
K
L
H
K
C
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
27.79
17%
22
* C4 *
-
5JK0
4
XERH_HELPY
A:
[2-363]
--------------------------------------
M
K
H
--
P
L
E
---
E
L
K
D
P
T
E
N
L
-----
L
L
W
I
--
G
R
F
L
R
Y
K
C
T
S
L
S
N
S
Q
V
K
-
D
---------
Q
N
K
--
V
F
E
--
C
L
N
E
L
N
Q
A
C
-----------------------------------------------------------
S
S
S
---
Q
L
E
K
-
V
C
K
K
A
R
N
A
G
L
L
G
I
N
T
----
Y
A
L
P
L
L
K
F
H
E
-
Y
F
S
K
A
R
L
I
---
A
F
N
------
S
L
K
N
-
I
D
E
V
M
L
A
E
F
L
S
V
Y
------
T
G
G
-----
L
S
L
A
T
K
K
-----
N
--
Y
R
I
A
L
----
L
----
G
L
F
S
Y
---
I
D
K
Q
N
Q
D
E
N
E
---
K
S
Y
I
Y
N
I
T
L
K
K
L
-
P
-
T
H
L
N
N
E
E
L
E
K
F
L
E
S
I
D
K
-----
I
-----
E
M
S
A
K
-------------
V
R
A
R
N
R
L
L
I
K
I
I
V
F
T
-
G
M
R
----
S
N
E
A
L
Q
L
K
I
K
D
-----------------------
F
T
L
E
N
G
C
Y
T
I
L
I
-----
K
G
K
G
D
K
Y
R
--
A
V
M
L
K
A
F
--
H
---------------
I
--
E
S
L
L
K
E
W
L
I
E
R
E
L
Y
P
V
----------------------------------
K
N
D
L
L
-
F
C
N
Q
K
G
S
------------------------------
A
L
T
Q
A
Y
L
Y
K
Q
V
E
R
I
I
N
F
A
G
L
-------
R
R
------------
E
K
N
G
A
H
M
L
R
H
S
F
A
T
L
L
Y
Q
K
R
H
-
D
L
I
L
V
--
Q
-
E
-
A
L
G
------
H
A
S
-
L
N
T
-
S
R
I
Y
T
H
------------------------
F
D
K
Q
R
L
E
E
A
A
S
I
W
E
E
N
--------------------
30
Fugue
27.65
13%
-
* C6 *
-
4U1D
-
EIF3A_YEAST
A:
[6-493]
-----------------------------------------------------------------------
F
R
P
E
N
A
I
K
R
-
A
D
E
L
I
-
S
---------
V
G
E
--
K
Q
A
--
A
L
Q
S
L
H
D
F
I
T
A
R
R
I
R
W
A
T
P
-
S
--------------------
T
V
---
E
P
V
V
F
K
F
---
L
E
I
-
G
V
E
L
K
K
--
G
K
L
---
L
K
D
G
-
L
H
Q
Y
K
K
L
I
Q
G
S
T
E
G
L
----
V
S
V
G
A
V
A
R
K
F
-
I
D
L
V
E
S
K
I
---
A
S
E
Q
T
R
---
A
D
E
L
-
Q
K
Q
E
I
D
A
I
T
S
W
L
R
------
F
T
W
-----
E
S
Y
R
A
V
L
-----
D
--
L
L
R
-
N
----
N
----
A
L
L
E
I
---
T
Y
S
G
V
V
K
K
T
M
H
F
C
L
K
Y
Q
R
K
N
E
F
K
R
L
-
A
-
E
M
L
R
Q
H
L
D
A
A
N
Y
Q
Q
S
K
S
-----
G
-----
N
N
L
V
D
---
L
S
D
A
----
D
T
L
Q
R
Y
L
D
Q
R
F
Q
Q
V
D
V
S
V
K
----------
L
E
L
W
H
E
A
Y
R
S
I
E
D
V
F
H
L
M
K
I
S
K
R
A
P
K
P
S
T
L
A
N
Y
Y
E
N
L
V
K
V
F
F
-----
V
S
G
D
P
L
L
H
--
T
T
A
W
K
K
F
--
Y
K
L
---
Y
S
T
N
P
R
---
A
T
--
E
E
E
F
K
T
Y
--
S
S
T
I
F
L
S
A
ISTQ
L
D
E
I
P
S
I
--
G
Y
D
P
H
L
R
M
Y
R
L
L
N
-------
L
D
A
K
P
-
T
---
R
K
E
M
L
Q
S
-----
I
I
E
D
-
E
S
I
Y
--
G
K
V
-
D
E
E
L
-
K
E
L
Y
D
I
I
E
V
N
F
D
V
D
T
V
K
Q
Q
-
L
E
N
L
L
V
K
L
S
S
------------
K
T
Y
F
S
Q
Y
I
A
P
L
R
D
V
I
M
R
R
V
F
V
-
A
A
S
Q
K
--
F
-
T
-
T
V
S
Q
S
E
L
Y
K
L
A
T
-
L
P
A
-
P
L
-----------------------------
D
L
S
A
W
D
I
E
K
S
L
L
Q
A
A
V
E
D
Y
V
SI
T
I
D
H
E
S
A
KVTFAK
21
HHSearch
25.57
31%
-76
- C5 -
-
2QV6
-
GCH3_METJA
C:
[82-107]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
V
S
M
V
I
A
S
A
E
T
-
P
-
Y
E
A
Q
K
L
A
T
E
T
L
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
24.37
31%
-80
- C5 -
-
2QV6
-
GCH3_METJA
D:
[82-107]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
V
S
M
V
I
A
S
A
E
T
-
P
-
Y
E
A
Q
K
L
A
T
E
T
L
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
22.45
46%
-40
- C5 -
-
2QV6
1
GCH3_METJA
C:
[211-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
A
G
I
G
I
G
R
T
-
A
-
E
D
A
S
N
L
A
D
I
G
L
E
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
20.77
19%
-50
- C5 -
-
2W0R
-
?
A:
[41-133]
-------------------------------------------------------
R
E
N
-----
V
K
R
S
--
S
V
V
V
A
D
P
T
H
I
A
-
I
G
I
L
Y
-
K
---------
R
G
E
TP
L
P
L
VT
F
K
Y
T
D
A
Q
V
Q
T
V
R
K
I
A
E
E
E
G
-
V
--------------------
P
I
L
Q
R
I
P
L
A
R
A
L
Y
W
D
A
L
V
-
D
H
Y
I
P
A
----
E
---
Q
I
E
A
-
T
A
E
V
L
R
W
L
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------