@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKU7: (2017-10-29 )
MLDSKQCEAFLAVAEVGSFDAAGEYLCITPSAVSLRVQALEKYLGQILIIRGRPCVLTQAGQTLLQHLRHTRLMEQNLLQGLMGKSSDSEFYKIALASNADSLATWLLPSIQQTLFKEKIVLELKIDDQSHTHTLLETGQVNACITAEEQVMAGCLAQPLGKMRYKMLASAEFVNRWFSGGINREVLRKTPAVIFNHKDLMHSEVLLKGYGLPMQSYPYSFIPATDAFVKAIQLGLGYGMVPELQVQPLLENETLVDIMPEAQLDVPLYWHHWKRQSKQLDVLTETIVESAKQILR
Atome Classification :
(20 SA)
.........10........20........30........40........50-.-.-......60......----..70..-......80........90......-..100.......110.....--.--.---120.......130.......140.......150-.........160........170.......180.......190....--....200.-.......210------------..-.....220.......-.230........240.......250-....--.-..---260--.---........270.......280.......290....--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ML
D
S
K
Q
C
E
A
F
L
A
V
A
EVGSFDAAG
E
Y
L
C
IT
P
S
A
V
S
L
R
V
Q
A
L
E
K
Y
LG
Q
I
L
I
IR-G-R-
P
C
V
L
T
Q
A
G
Q
T
L
L
Q
H
----
L
R
H
T
R
L
-
M
E
Q
N
L
L
Q
G
L
MGKSSDS
E
F
Y
K
I
A
LA-SN
A
D
S
L
A
T
W
L
L
P
S
I
Q
Q
T
L
F
K--E--
K
---
I
V
L
E
L
K
IDDQSH
T
H
T
L
LETGQV
N
A
C
I
T
A
E
E
Q
---
V
M
A
G
C
L
A
Q
P
L
-
G
K
M
R
Y
K
M
L
A
S
A
E
F
V
N
R
W
F
SGGI
N
R
E
V
L
RKT
P
-
A
V
I
F--N
H
K
D
L
-
M
H
-
S
E
V
L
L
K
GYGL------------PM-QSYPYSF-IP
A
T
D
A
F
-
V
K
A
-
I
Q
L
GLGYGMVP
E
L
Q
V
Q
PLLEN-E
T
L
V
--
D
-IM---P----E---AQLDV
P
L
Y
W
H
H
W
K
R
Q
S
K
Q
L
D
V
L
T
E
T
I
V
E
S
A
K
Q
ILR--
38
Fugue
87.82
37%
-124
* C3 *
-
3ISP
-
Y1985_MYCTU
A:
[5-296]
Q
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
-
E
-
K
-
P
C
R
A
T
T
A
G
I
P
L
L
R
L
----
A
A
Q
T
A
L
-
L
E
S
E
A
L
A
E
M
---
G
A
S
L
K
R
T
R
I
T
I
A
-
V
N
A
D
S
M
A
T
W
F
S
A
V
F
D
G
L
-----
G
--
D
---
V
L
L
D
V
R
I
E
D
Q
D
H
S
A
R
L
L
R
E
G
V
A
M
G
A
V
T
T
E
R
N
---
P
V
P
G
C
R
V
H
P
L
-
G
E
M
R
Y
L
P
V
A
S
R
P
F
V
Q
R
H
L
S
D
G
F
T
A
A
A
A
A
K
A
P
-
S
L
A
W
--
N
R
D
D
G
-
L
Q
-
D
M
L
V
R
K
A
F
R
R
------------
A
--
I
T
R
P
T
H
F
-
V
P
T
T
E
G
F
-
T
A
A
-
A
R
A
G
L
G
W
G
M
F
P
E
K
L
A
A
S
P
L
A
D
-
G
S
F
V
--
R
-
V
C
---
D
----
I
----
H
L
D
V
P
L
Y
W
Q
C
W
K
L
D
S
P
I
I
A
R
I
T
D
T
V
R
A
A
A
S
G
L
Y
R
GQ
33
HHSearch
86.86
37%
-128
- C3 -
-
3ISP
-
Y1985_MYCTU
A:
[5-292]
Q
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
-
E
-
K
-
P
C
R
A
T
T
A
G
I
P
L
L
R
L
----
A
A
Q
T
A
L
-
L
E
S
E
A
L
A
E
M
G
--
A
-
S
L
K
R
T
R
I
T
I
A
-
V
N
A
D
S
M
A
T
W
F
S
A
V
F
D
G
L
G
-------
D
---
V
L
L
D
V
R
I
E
D
Q
D
H
S
A
R
L
L
R
E
G
V
A
M
G
A
V
T
T
E
R
N
---
P
V
P
G
C
R
V
H
P
L
-
G
E
M
R
Y
L
P
V
A
S
R
P
F
V
Q
R
H
L
S
D
G
F
T
A
A
A
A
A
K
A
P
-
S
L
A
W
--
N
R
D
D
G
-
L
Q
-
D
M
L
V
R
K
A
F
R
R
------------
A
--
I
T
R
P
T
H
F
-
V
P
T
T
E
G
F
-
T
A
A
-
A
R
A
G
L
G
W
G
M
F
P
E
K
L
A
A
S
P
L
A
D
-
G
S
F
V
--
R
-
V
C
---
D
--------
I
H
L
D
V
P
L
Y
W
Q
C
W
K
L
D
S
P
I
I
A
R
I
T
D
T
V
R
A
A
A
S
G
L
----
32
HHSearch
84.85
37%
-149
- C3 -
-
3ISP
-
Y1985_MYCTU
B:
[5-292]
Q
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
-
E
-
K
-
P
C
R
A
T
T
A
G
I
P
L
L
R
L
----
A
A
Q
T
A
L
-
L
E
S
E
A
L
A
E
M
-------
K
R
T
R
I
T
I
A
-
V
N
A
D
S
M
A
T
W
F
S
A
V
F
D
G
L
G
-------
D
---
V
L
L
D
V
R
I
E
D
Q
D
H
S
A
R
L
L
R
E
G
V
A
M
G
A
V
T
T
E
R
N
---
P
V
P
G
C
R
V
H
P
L
-
G
E
M
R
Y
L
P
V
A
S
R
P
F
V
Q
R
H
--
D
G
F
T
A
A
A
A
A
K
A
P
-
S
L
A
W
--
N
------------------------------------
P
T
H
F
-
V
P
T
T
E
G
F
-
T
A
A
-
A
R
A
G
L
G
W
G
M
F
P
E
K
L
A
A
S
P
L
A
D
-
G
S
F
V
--
R
-
V
C
---
D
--------
I
H
L
D
V
P
L
Y
W
Q
C
W
K
L
D
S
P
I
I
A
R
I
T
D
T
V
R
A
A
A
S
G
L
----
1
PsiBlast_PDB
77.16
36%
-31
- C3 -
-
3ISP
-
Y1985_MYCTU
A:
[6-292]
-
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
-
E
-
K
-
P
C
R
A
T
T
A
G
I
P
L
L
R
L
----
A
A
Q
T
A
L
-
L
E
S
E
A
L
-
A
E
M
G
--
A
S
L
K
R
T
R
I
T
I
A
-
V
N
A
D
S
M
A
T
W
F
-----
S
A
V
F
D
GL
G
--
D
---
V
L
L
D
V
R
I
E
D
Q
D
H
S
A
R
L
L
R
E
G
V
A
M
G
A
V
T
T
E
R
N
---
P
V
P
G
C
R
V
H
P
L
-
G
E
M
R
Y
L
P
V
A
S
R
P
F
V
Q
R
H
L
S
D
G
F
T
A
A
A
A
A
K
A
P
-
S
L
A
W
--
N
R
D
D
G
-
L
Q
-
D
M
L
V
R
K
A
F
R
R
------------
A
I
--
T
R
P
T
H
F
-
V
P
T
T
E
G
F
-
T
A
A
-
A
R
A
G
L
G
W
G
M
F
P
E
K
L
A
A
S
P
L
A
D
-
G
S
F
V
--
R
-
V
C
--------
D
---
I
H
L
D
V
P
L
Y
W
Q
C
W
K
L
D
S
P
I
I
A
R
I
T
D
T
V
R
A
A
A
S
G
L
----
2
PsiBlast_PDB
75.50
35%
-136
- C3 -
-
3FD3
3
?
A:
[6-204]
-------------------------------------------------------------------------------------------------------
I
A
-
T
N
A
D
S
L
G
T
W
F
L
D
A
V
S
K
F
T
G
G
--
S
--
D
---
Y
L
V
N
I
A
V
D
D
Q
D
H
T
V
E
W
L
R
G
G
R
V
L
A
A
V
T
A
H
D
K
---
P
V
Q
G
C
R
V
T
P
L
-
G
V
L
R
Y
H
A
T
A
S
P
D
F
M
A
R
H
F
A
D
G
V
T
P
A
A
L
A
R
A
P
-
G
L
T
F
--
N
Q
K
D
R
-
L
Q
-
A
S
W
I
R
T
A
L
G
E
------------
D
V
--
S
Y
P
T
H
W
-
L
P
S
T
D
G
F
-
V
K
A
-
S
L
A
G
M
G
W
G
L
N
P
V
Q
L
V
A
E
H
L
A
A
-
G
R
L
V
--
E
-
L
M
---
P
----
G
---
T
P
L
D
I
P
L
Y
W
Q
V
N
R
L
A
A
E
R
L
A
G
L
T
A
N
M
V
G
T
A
R
V
V
L
---
29
HHSearch
55.02
15%
-53
- C3 -
-
4X6G
2
?
E:
[7-307]
-
M
T
L
T
E
L
R
Y
I
V
T
L
A
Q
E
Q
H
F
G
R
A
A
E
R
C
H
V
S
Q
P
T
L
S
V
G
V
K
K
L
E
D
E
L
G
V
L
I
F
E
-------
V
R
L
T
P
V
G
E
G
I
V
A
Q
----
A
Q
K
V
L
E
-
Q
A
Q
G
I
R
E
L
A
Q
A
G
K
-
N
Q
L
A
A
P
L
K
V
G
-
A
I
Y
T
I
G
P
Y
L
F
P
H
L
I
P
Q
L
H
R
V
--
A
P
-
Q
---
M
P
L
Y
I
E
E
N
F
T
H
I
L
R
D
K
L
R
T
G
E
L
D
A
I
I
I
A
L
P
F
---
Q
E
A
D
V
L
T
K
P
L
-
F
D
E
P
F
Y
V
L
M
P
A
D
H
P
W
T
A
-
K
A
S
I
D
S
E
L
L
N
D
K
S
-
L
L
L
L
--
G
E
G
H
D
-
F
R
--
D
Q
V
L
E
A
C
P
T
V
R
K
G--------
D
E
-
N
K
H
T
T
V
E
-
S
S
S
L
E
T
I
-
R
H
M
-
V
A
S
G
L
G
V
S
V
L
P
F
S
A
V
D
S
H
H
Y
A
P
G
V
I
E
V
R
P
-
F
S
---
A
P
---
V
---
P
F
R
T
V
A
I
A
W
R
A
S
F
P
R
P
R
A
I
E
V
L
A
D
S
I
R
L
C
S
V
A
R
P
---
3
PsiBlast_PDB
54.44
20%
-
- C3 -
-
3SZP
-
?
A:
[9-286]
---------
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
-
R
-
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
R
L
A
S
-
M
T
E
E
I
T
D
E
C
R
G
A
S
G
-----
R
I
R
I
S
-
A
P
S
N
L
T
K
R
M
M
M
P
M
F
N
A
--
F
M
--
E
--
K
Y
PD
I
H
I
E
L
M
M
S
N
Q
A
D
D
---
L
D
P
T
E
W
D
V
I
F
R
V
G
P
Q
---
R
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
I
L
V
A
S
P
Q
Y
L
S
S
-----------
H
P
Q
P
-
T
------
H
A
E
E
-
L
H
-
Q
H
Q
L
L
K
G
Y
P
L
L
K
W
Q
L
T
N
SQG
E
T
V
V
-
N
S
D
R
G
R
F
Q
A
S
A
L
N
V
V
-
R
S
A
-
C
S
E
G
L
G
I
T
L
M
P
D
V
M
L
R
E
F
L
E
D
-
G
S
L
V
--
Q
-
V
L
---
S
----
D
WSS
N
P
R
D
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
R
L
F
I
D
F
V
I
----------
4
PsiBlast_PDB
53.69
20%
-
- C3 -
-
3T1B
-
?
B:
[9-286]
---------
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
-
R
-
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
R
L
A
S
-
M
T
E
E
I
T
D
E
C
R
G
A
S
G
-----
R
I
R
I
S
-
A
P
S
E
L
T
K
R
M
M
M
P
M
F
N
A
--
F
M
--
E
--
K
Y
PD
I
H
I
E
L
M
M
S
N
Q
A
D
----
L
D
P
T
E
W
D
V
I
F
R
V
G
P
Q
---
R
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
I
L
V
A
S
P
Q
Y
L
S
S
-----------
H
P
Q
P
-
T
------
H
A
E
E
-
L
H
-
Q
H
Q
L
L
K
G
Y
P
L
LK
W
Q
L
T
N
S
QGE
T
V
V
-
N
S
D
R
G
R
F
Q
A
S
A
L
N
V
V
-
R
S
A
-
C
S
E
G
L
G
I
T
L
M
P
D
V
M
L
R
E
F
L
E
D
-
G
S
L
V
--
Q
-
V
L
---
S
----
D
WSS
N
P
R
D
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
R
L
F
I
D
F
V
I
----------
30
HHSearch
52.51
15%
-31
- C3 -
-
4X6G
4
?
A:
[7-303]
-
M
T
L
T
E
L
R
Y
I
V
T
L
A
Q
E
Q
H
F
G
R
A
A
E
R
C
H
V
S
Q
P
T
L
S
V
G
V
K
K
L
E
D
E
L
G
V
L
I
F
E
R
-
S
-
K
S
A
V
R
L
T
P
V
G
E
G
I
V
A
Q
----
A
Q
K
V
L
E
-
Q
A
Q
G
I
R
E
L
A
Q
A
G
K
-
N
Q
L
A
A
P
L
K
V
G
-
A
I
Y
T
I
G
P
Y
L
F
P
H
L
I
P
Q
L
H
R
V
--
A
P-
Q
---
M
P
L
Y
I
E
E
N
F
T
H
I
L
R
D
K
L
R
T
G
E
L
D
A
I
I
I
A
L
P
F
---
Q
E
A
D
V
L
T
K
P
L
-
F
D
E
P
F
Y
V
L
M
P
A
D
H
P
W
T
A
-
K
A
S
I
D
S
E
L
L
N
D
K
S
-
L
L
L
L
--
G
E
G
H
D
-
F
R
--
D
Q
V
L
E
A
C
P
T
V
R
K
G--------
D
E
-
N
K
H
T
T
V
E
-
S
S
S
L
E
T
I
-
R
H
M
-
V
A
S
G
L
G
V
S
V
L
P
F
S
A
V
D
S
H
H
Y
A
P
G
V
I
E
V
R
P
-
F
S
---
A
P---
V
---
P
F
R
T
V
A
I
A
W
R
A
S
F
P
R
P
R
A
I
E
V
L
A
D
S
I
R
L
C
S
-------
23
HHSearch
52.01
16%
-
- C3 -
-
3SZP
-
?
A:
[1-290]
-
M
K
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
-
H
-
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
----
C
S
P
L
L
E
-
R
L
A
S
M
T
E
E
I
T
D
E
C
-
R
G
A
S
G
R
I
R
I
S
-
A
P
S
N
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
--
Y
P-
D
---
I
H
I
E
L
M
M
S
N
Q
---
A
D
D
L
D
P
T
E
W
D
V
I
F
R
V
G
P
Q
---
R
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
I
L
V
A
S
P
Q
Y
L
S
S
H
-
P
Q
P
T
H
A
E
E
L
H
Q
H
Q
-
L
L
K
G
--
Y
P
L
---
L
K
-
W
Q
L
T
N
S
Q
G
E
T
V
-----------
V
N
-
S
D
R
G
R
F
Q
-
A
S
A
L
N
V
V
-
R
S
A
-
C
S
E
G
L
G
I
T
L
M
P
D
V
M
L
R
E
F
L
E
D
-
G
S
L
V
--
Q
-
V
L
---
S
DWS-
S
---
N
P
R
D
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
R
L
F
I
D
F
V
I
G
Y
H
L
------
18
HHSearch
52.01
20%
-26
- C3 -
-
3HHG
-
?
E:
[2-296]
K
T
N
S
E
E
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
-
T
-
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
----
A
Q
R
I
L
Q
-
E
M
A
A
A
E
T
E
M
L
A
V
H
-
E
I
P
Q
G
V
L
S
V
D
-
S
A
M
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
--
Y
P-
H
---
I
R
L
S
L
V
S
S
E
---
G
Y
I
N
L
I
E
R
K
V
D
I
A
L
R
A
G
E
L
---
D
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
R
V
I
A
S
P
E
Y
L
A
K
H
-
G
T
P
Q
S
T
E
E
L
A
G
H
Q
-
C
L
G
F
--
T
E
P
G
S
-
L
N
T
W
A
V
L
D
A
Q
G
-
N
------------
P
Y
-
K
I
S
P
H
F
T
-
A
S
S
G
E
I
L
-
R
S
L
-
C
L
S
G
C
G
I
V
C
L
S
D
F
L
V
D
N
D
I
A
E
-
G
K
L
I
--
P
-
L
L
---
A
EQTS
D
---
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
R
V
F
L
D
F
L
V
E
E
L
G
N
N
----
40
Fugue
51.95
16%
-34
- C3 -
-
1IZ1
-
?
A:
[1-292]
-
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
H
-
R
-
G
I
E
L
T
A
A
G
H
A
F
L
E
D
----
A
R
R
I
L
E
-
L
A
G
R
S
G
D
R
S
R
A
A
A
R
G
D
V
-
G
E
L
S
V
A
-
Y
F
-
G
T
P
I
Y
R
S
L
P
L
L
L
R
A
F
L
T
--
S
T
P
T
---
A
T
V
S
L
T
H
M
T
K
D
E
Q
V
E
G
L
L
A
G
T
I
H
V
G
F
S
R
F
F
P
---
R
H
P
G
I
E
I
V
N
I
-
A
Q
E
D
L
Y
L
A
V
H
R
S
Q
S
G
K
-
F
G
K
T
C
K
L
A
D
L
R
A
V
E
-
L
T
L
F
PR
G
G
R
P
S
-
F
A
-
D
E
V
I
G
L
F
K
H
A
------------
G
I
-
E
P
R
I
A
R
V
-
V
E
D
A
T
A
A
-
L
A
L
-
T
M
A
G
A
A
S
S
I
V
P
A
S
V
A
A
I
R
W
P
D
-
I
A
F
A
--
R
-
I
V
G
--
T
----
R
---
V
K
V
P
I
S
C
I
F
R
K
-
E
K
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
A
-------
19
HHSearch
51.69
16%
-39
- C3 -
-
1IZ1
-
?
B:
[1-293]
-
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
-
S
-
H
R
G
I
E
L
T
A
A
G
H
A
F
L
E
D
----
A
R
R
I
L
E
-
L
A
G
R
S
G
D
R
S
R
A
A
A
-
R
G
D
V
G
E
L
S
V
A
-
Y
F
G
T
P
I
Y
R
S
L
P
L
L
L
R
A
F
L
T
S
--
T
P-
T
---
A
T
V
S
L
T
H
M
T
K
D
E
Q
V
E
G
L
L
A
G
T
I
H
V
G
F
S
R
F
F
P
---
R
H
P
G
I
E
I
V
N
I
-
A
Q
E
D
L
Y
L
A
V
H
R
S
Q
S
G
K
F
-
G
K
T
C
K
L
A
D
L
R
A
V
E
-
L
T
L
F
--
P
R
G
G
R
P
S
F
-
A
D
E
V
I
G
L
F
K
H
A-----------
G
I
-
E
P
R
I
A
R
V
-
V
E
D
A
T
A
A
-
L
A
L
-
T
M
A
G
A
A
S
S
I
V
P
A
S
V
A
A
I
R
W
P
D
-
I
A
F
A
--
R
-
I
V
---
G
T---
R
---
V
K
V
P
I
S
C
I
F
R
K
E
K
-
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
A
K
------
17
HHSearch
51.46
16%
-36
- C3 -
-
3FXQ
6
TSAR_COMTE
A:
[1-296]
M
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
-
T
-
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
----
A
R
L
I
V
T
-
E
S
R
R
A
Q
E
E
I
G
Q
L
R
-
G
R
W
E
G
H
I
T
F
A
-
A
S
P
A
I
A
L
A
A
L
P
L
A
L
A
S
F
A
R
E
--
F
P-
D
---
V
T
V
N
V
R
D
G
M
Y
P
A
V
S
P
Q
L
R
D
G
T
L
D
F
A
L
T
A
A
H
K
HD-
I
D
T
D
L
E
A
Q
P
L
-
Y
V
S
D
V
V
I
V
G
Q
R
Q
H
P
M
A
N
---
A
T
R
L
A
E
L
Q
E
C
R
-
W
A
F
S
--
S
A
P
R
G
-
P
--
G
A
I
I
R
N
A
F
A
R
Y
-----------
G
L
P
E
P
K
L
G
L
V
-
C
E
S
F
L
A
L
-
P
G
V
-
V
A
H
S
D
L
L
T
T
M
P
R
T
L
Y
E
R
N
A
F
K
-
D
Q
L
C
--
S
-
I
P
LQ-
D
A
---
L
---
P
N
P
T
I
Y
V
L
R
R
H
D
L
P
V
T
P
A
A
A
G
L
I
R
W
I
Q
H
H
A
L
------
14
PsiBlast_PDB
50.60
35%
-135
- C3 -
-
1IZ1
-
?
A:
[1-80]
-
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
-
S
H
R
-
G
I
E
L
T
A
A
G
H
A
F
L
E
D
----
A
R
--
R
I
-
L
E
------
L
A
G
R
S
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
46.19
15%
-52
- C3 -
-
2ESN
-
?
B:
[7-305]
R
L
D
L
N
L
L
L
V
F
D
A
L
Y
R
H
R
N
V
G
T
A
A
S
E
L
A
I
S
A
S
A
F
S
H
A
L
G
R
L
R
Q
G
L
D
D
E
L
F
L
R
-
Q
-
G
N
R
M
Q
P
T
Q
R
A
E
H
L
A
A
A
----
V
A
A
A
L
R
-
A
L
G
E
G
L
E
E
W
R
P
F
V
P
G
Q
S
Q
R
T
F
V
F
A
-
A
T
D
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
--
A
P-
G
---
V
R
L
R
L
V
N
A
E
R
K
L
S
V
E
A
L
A
S
G
R
I
D
F
A
L
G
Y
D
E
E
HER
L
P
E
G
I
Q
A
H
D
W
-
F
A
D
R
Y
V
V
V
A
R
R
D
H
P
R
L
A
--
G
A
P
T
L
E
G
Y
L
A
E
R
-
H
A
V
V
--
T
P
W
N
E
-
D
S
--
G
V
I
D
R
L
L
A
R
S
-----------
G
L
-
R
R
E
V
A
V
Q
-
L
P
T
V
L
A
A
-
L
F
L
-
A
G
S
T
D
F
L
L
T
A
P
R
H
A
A
R
A
L
A
E
A
-
A
G
L
A
--
L
-
Y
P
A
P
-
F
----
D
I
--
P
P
Y
V
L
R
L
Y
S
H
V
Q
----
D
A
H
A
W
M
I
G
Q
L
K
G
L
D
I
S
-----
12
PsiBlast_PDB
45.66
24%
-34
- C3 -
-
3HHG
-
?
A:
[4-237]
--
N
S
E
E
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
T
-
R
-
Q
L
S
L
T
E
E
G
A
---
Q
Y
----
F
R
R
A
Q
R
-
I
L
Q
E
M
A
A
A
E
T
E
M
L
A
V
H
E
I
P
Q
G
V
L
S
V
D
S
A
M
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
--
R
--
Y
---
P
H
I
R
L
S
L
V
S
S
E
G
Y
I
N
L
I
E
R
-
K
V
D
I
A
L
R
A
G
E
L
---
D
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
R
V
I
A
S
P
E
Y
L
A
K
H
G
T
P
Q
S
T
E
E
-
L
A
G
H
Q
-
C
L
G
F
--
T
E
P
G
S
-
L
N
-
T
W
A
V
L
D
A
Q
G
N
------------
P
Y
-
K
I
S
P
H
-
F
-
T
A
S
S
G
E
I
-
L
R
S
-
L
C
L
S
-
G
C
G
I
V
-----------------------------------------------------------------------
41
Fugue
44.37
16%
-20
- C3 -
-
3FZV
-
?
A:
[4-300]
-
Y
T
L
R
Q
L
K
Y
F
V
T
T
V
E
C
G
S
V
A
E
A
S
R
K
L
Y
I
A
Q
S
-
I
S
T
A
V
K
G
L
E
E
S
F
V
Q
L
-----------
F
L
T
P
A
G
A
R
F
Y
R
K
----
A
Q
E
L
L
R
M
A
H
E
F
E
Q
N
L
-
A
D
N
D
V
I
A
G
Q
I
D
I
G
C
F
----
E
T
V
A
P
L
Y
L
P
G
L
I
A
G
F
R
Q
--
A
--
Y
PG-
V
E
I
R
I
R
D
G
E
Q
Q
E
L
V
Q
G
L
T
S
G
R
F
D
L
A
F
L
Y
E
H
D
---
L
D
S
T
I
E
T
E
P
L
M
P
P
Q
R
P
H
A
L
L
P
E
G
H
-
R
F
A
G
Q
A
Q
V
S
L
R
D
L
C
L
E
P
M
I
L
L
D
--
V
Q
P
S
R
-
T
Y
-
F
V
S
L
F
E
E
L
G
L
------------
T
P
-
N
I
A
F
S
S
-----
P
S
I
E
M
V
R
G
M
V
G
Q
G
F
G
F
S
L
L
V
T
R
P
H
S
E
C
T
Y
D
-
G
K
K
V
--
V
M
V
D
L
A
E
P
----
V
---
S
T
S
G
L
A
A
A
W
L
K
R
A
Q
L
T
K
P
A
R
L
F
V
D
Y
C
R
E
Q
L
G
K
-----
10
PsiBlast_PDB
42.95
40%
-149
- C3 -
-
4IHS
-
BENM_ACIAD
A:
[9-67]
---------
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
-
G
S
R
-
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
42.87
35%
-148
- C3 -
-
3K1N
-
BENM_ACIAD
A:
[1-67]
-
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
-
G
S
R
-
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------