@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKX7: (2017-10-30 )
MGRTSSSGLPKGTRARSGKIQINFKWNDKREWFTLDLIDTPANFIKAAKIREDFVNKAKYGILKIEDIKAVTAKPIKKADASQKTLPASNAPTFAHYAQEYLYNLSDHKQGTKKKYLSILERLWMPLFEDMPINTITSQMLRTAVNGREWSSAKTRNDALIPLRGVFELACDDEVIDKNPCDRLKNQKTQEDEPDPFNEMEKEIILNWLKEKYISDYPTVYWYFVVAFWTGCRPSEIIALTWQDVDFLNKQIYINKGRVNGVQQETTKTNKARFVDLNDFAFEAFQQLRLLTYLKYEHVFICDETGKEFTTQKSLSEKFVASLKANGIRYRPAYNTRHTYATVCLMNGLNPVYVASQLGHSLVMLMMRYAKWINSDKNKEEIAKISNSAKIVPNKKGIKLSV
Atome Classification :
(20 SA)
-.........10........20-----.........30...-----.....40........50........------------60........70---.........80........90........100....-.--..-----110.......120.........130--------.........140......-.---150-.........160.......170.....--..180..-----.....-------190......-.200.......------210..--------..--...220----.......230----...----------------------------......240...---------....-250.......260-------.-------...----------------------.....-270...-------....280-----.....---------....290---------.-------------------------------..-....300...-.---------.-------..-310.-----......320------..-----.....-.----330.--.......340.......350.......360........370-.........380........390.......400------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MGRTSSSGLPKGTRARS
G
K
I
------
Q
I
N
F
K
WNDK
R
E
W
F
T
-----
L
D
LIDT
P
A
N
F
I
K
A
A
K
I
R
E
D
F
V
N
KAK------------Y
G
I
L
K
I
E
D
I
K
A
----
V
T
AKPIKKADASQKTLPASNA
P
T
F
A
H
Y
A
Q
E
Y
L
Y
N
L
S
-D--HK-----QG
T
K
K
K
Y
L
S
I
L
--
E
R
L
W
M
P
L
FED----------MP
I
N
T
I
T
S
Q
M
L
R
T
AVNGR-E---W---SSAKTRND
A
L
I
P
L
R
G
V
F
ELACDDEVID--KN
P
C
D
R
L-----KNQKT-------QEDEPD
P
F
N
-
E
M
E
K
E
I
I
L
N
W
L
------
K
E
K
Y
I
--------
S
D--YP
T
V
Y
W
----
Y
F
V
V
A
F
WT------GCR----------------------------P
S
E
I
I
A
L
T
WQ
D
V
---------
D
FLN-
K
Q
I
Y
I
NKGRVN---------G-------
V
Q
Q
----------------------ETTKT-NK
A
R
F
V
-------D
L
N
D
F
-------
A
F
E
A
F
---------
Q
Q
L
R
L
L
T
---------
Y
-------------------------------
L
K
-
Y
E
H
V
F
I
CDET-G---------K-------EF-
T
T
Q
K
-----
S
L
S
E
K
F
V
A
-------
S
L-----KAN
G
I
-
R
----YR-P--AYNTR
H
T
Y
A
T
V
C
L
MNGL
N
P
V
Y
V
A
S
Q
L
G
H
S
-
L
V
M
L
M
M
R
Y
A
---
K
W
INSDK
N
K
E
-
E
I
A
K
ISNS
A
K
IVPNKK
G
I
KLSV------------------------------------
24
Fugue
80.10
19%
-15
- C5 -
-
5JK0
4
XERH_HELPY
A:
[2-363]
---------
M
K
H
P
L
E
E
L
K
D
P
T
------
E
N
L
L
L
W
I
G
R
--
F
L
R
-----
Y
K
C
T
S
L
S
N
S
Q
V
K
D
Q
N
K
V
F
E
C
L
N
E
L
N
---------------------
Q
A
----
C
S
S
S
Q
L
E
K
V
C
K
K
A
R
N
A
G
L
L
G
I
N
T
Y
A
L
P
L
L
K
F
H
E
Y
F
S
-
K
--
A
R
------------------------
L
I
A
F
----------
N
S
L
K
N
I
D
E
V
M
L
A
E
F
L
S
V
Y
T
G
---
G
---
L
S
L
A
T
K
K
N
Y
R
I
A
L
L
G
L
F
S
Y
I
D
K
Q
N
Q
-
D
--
E
N
E
K
S
Y
I
-----
Y
N
-
I
T
-------
L
K
K
L
P
T
H
L
N
-
N
E
E
L
E
K
F
L
E
S
I
------
D
K
I
E
M
--------
S
A
KV
R
A
R
N
R
L
----
L
I
K
I
I
V
F
T
------
G
M
R
----------------------------
S
N
E
A
L
Q
L
K
I
K
D
F
---------
T
L
E
N
-
G
C
Y
T
I
L
I
K
-----------------------------------------------
G
K
G
-
D
K
Y
R
A
V
-------
M
L
K
A
F
-------
H
I
E
S
L
---------
L
K
E
W
L
I
E
R
E
L
------
Y
-------------------------------
P
V
-
K
N
D
L
L
F
C
N
Q
K
-
G
---------
S
-------
A
L
-
T
-
Q
A
-----
Y
L
Y
K
Q
V
E
R
-------
I
I
-----
N
F
A
G
L
-
R
----
R
E
-
K
NG
A
H
M
L
R
H
S
F
A
T
L
L
Y
Q
K
R
H
D
L
I
L
V
Q
E
A
L
G
H
A
-
S
L
N
T
S
R
I
Y
T
---
H
F
--
D
K
Q
R
L
E
-
E
A
A
S
I
W
E
E
N
-------------------------------------------------
32
HHSearch
72.42
18%
-38
- C5 -
-
2A3V
-
?
B:
[5-316]
-------------------------------------------------------------------------------------------------------------------------
F
L
L
S
V
R
E
F
M
Q
T
R
Y
----
Y
A
-----
K
K
T
I
E
A
Y
L
H
W
I
--
T
R
Y
-
I
H
F
H
N
K
----------
K
H
P
S
L
M
G
D
K
E
V
E
E
F
L
T
Y
L
-
A
---
V
Q
GK
V
A
T
K
T
Q
S
L
A
L
N
S
L
S
F
L
Y
K
E
I
L
K
T
P
L
S
L
--
E
I
R
F
--------
Q
R
S
Q
L
-------
E
R
K
L
P
V
V
L
T
-
R
D
E
I
R
R
L
L
E
I
V
------
D
P
-----------------
K
H
Q
L
----
P
I
K
L
L
Y
G
S
------
G
L
R
----------------------------
L
M
E
C
M
R
L
R
V
Q
D
I
---------
D
F
D
Y
-
G
A
I
R
I
W
------------------------------------------------
Q
G
K
G
-
G
K
N
R
T
V
-------
T
L
A
K
E
-------
L
Y
P
H
L
---------
K
E
Q
I
A
L
A
---------
K
R
Y
Y
D
R
D
LHQKNYGGVWLP
T
A
L
K
E
K
Y
P
NAPYE
F
R
-
W
H
Y
L
F
P
S
F
Q
L
-
S
L
D
PESD
V
M
R
R
-------
H
H
-
M
N
E
T
-----
V
L
Q
K
A
V
R
R
-------
S
A
-----
Q
E
A
G
I
-
E
K---
T
V
-
T
--
C
H
T
L
R
H
S
F
A
T
H
L
L
E
V
G
A
D
I
R
T
V
Q
E
Q
L
G
H
T
D
V
K
T
T
-
Q
I
Y
T
---
H
V
L
D
R
G
A
S
-
G
-
V
L
S
P
------------------------------------------------------
33
HHSearch
69.06
18%
-21
- C5 -
-
2A3V
-
?
C:
[5-316]
-------------------------------------------------------------------------------------------------------------------------
F
L
L
S
V
R
E
F
M
Q
T
R
Y
----
Y
A
-----
K
K
T
I
E
A
Y
L
H
W
I
--
T
R
Y
-
I
H
F
H
N
K
----------
K
H
P
S
L
M
G
D
K
E
V
E
E
F
L
T
Y
L
-
A
---
V
QGK
V
A
T
K
T
Q
S
L
A
L
N
S
L
S
F
L
Y
K
E
I
L
K
T
P
L
S
L
--
E
I
R
F
--------
Q
R
S
Q
L
-------
E
R
K
L
P
V
V
L
T
-
R
D
E
I
R
R
L
L
E
I
V
------
D
P
-----------------
K
H
Q
L
----
P
I
K
L
L
Y
G
S
------
G
L
R
----------------------------
L
M
E
C
M
R
L
R
V
Q
D
I
---------
D
F
D
Y
-
G
A
I
R
I
W
------------------------------------------------
Q
G
K
G
-
G
K
N
R
T
V
-------
T
L
A
K
E
-------
L
Y
P
H
L
---------
K
E
Q
I
A
L
A
---------
K
RYYDRDLHQKNYGGVWLPTALKEKYPNAPYE
F
R
-
W
H
Y
L
F
P
S
F
Q
L
-
S
LDPESDVMR
R
-------
H
H
-
M
N
E
T
-----
V
L
Q
K
A
V
R
R
-------
S
A
-----
Q
E
A
G
I
-
E
K---
T
V
-
T
--
C
H
T
L
R
H
S
F
A
T
H
L
L
E
V
G
A
D
I
R
T
V
Q
E
Q
L
G
H
T
D
V
K
T
T
-
Q
I
Y
T
---
H
---
R
G
A
S
-
G
-
V
L
S
P
------------------------------------------------------
39
HHSearch
65.66
19%
-25
- C5 -
-
5JK0
4
XERH_HELPY
A:
[56-352]
---------------------------------------------------------------------------------------------------------------------------
S
Q
L
E
K
V
C
K
K
A
R
-
N
--
A
G
-----
L
L
G
I
N
T
Y
A
L
P
L
--
L
K
-
F
H
E
Y
F
S
K
ARLIAF----
N
S
L
K
N
I
D
E
V
M
L
A
E
F
L
S
V
Y
-
T
G--
G
---
L
S
L
A
T
K
K
N
Y
R
I
A
L
L
G
L
F
S
Y
I
D
K
Q
N
Q
D
E
NE
K
S
Y
I
Y
N
I
TLK----------------
K
L
P
T
H
L
N
-
N
E
E
L
E
K
F
L
E
S
I
------
D
K
I
E
M
S
A------
K
V
--
R
A
R
N
R
L
----
L
I
K
I
I
V
F
T
------
G
M
R
----------------------------
S
N
E
A
L
Q
L
K
I
K
D
F
---------
T
L
E
N
-
G
C
Y
T
I
L
I
-----------------------------------------------
K
G
K
G
-
D
K
Y
R
A
V
-------
M
L
K
A
F
H------
I
E
S
L
L
---------
K
E
W
L
I
E
R
---------
E
L
YP----------------------------
V
K
-
N
D
L
L
F
C
N
Q
-
K
-
G
---------
S
-------
A
--
L
T
Q
A
-----
Y
L
Y
K
Q
V
E
R
-------
I
I
-----
N
F
A
G
L
-
R
RE--
K
N
-
G
--
A
H
M
L
R
H
S
F
A
T
L
L
Y
Q
K
R
H
D
L
I
L
V
Q
E
A
L
G
H
A
S
L
N
T
S
-
R
I
Y
T
---
H
F
D
K
Q
R
---------------------------------------------------------------
38
HHSearch
65.64
19%
16
- C5 -
-
4A8E
1
XERA_PYRAB
A:
[9-279]
-------------------------------------------------------------------------------------------------------------------------
R
D
D
T
I
E
E
F
A
T
Y
L
E
-
L
E
G
K
S
-----
R
N
T
V
R
M
Y
T
Y
Y
I
--
S
K
F
F
-
E
---------------
E
G
H
S
P
T
A
R
D
A
L
R
F
L
A
K
L
-
K
R
K
-
G
---
Y
S
T
R
S
L
N
L
V
I
Q
A
L
K
A
Y
F
K
F
E
G
L
D
-------
S
E
A
E
K
L
-----
K
T
P
K
M
-------
P
K
T
L
P
K
S
L
T
-
E
E
E
V
R
R
I
I
N
A
A
------
E
T
----------------
L
R
D
R
L
----
I
L
L
L
L
Y
G
A
------
G
L
R
----------------------------
V
S
E
L
C
N
L
R
V
E
D
V
---------
N
F
E
Y
-
G
V
I
V
V
R
------------------------------------------------
G
G
K
G
-
G
K
D
R
V
V
-------
P
I
S
E
S
-------
L
L
S
E
I
---------
K
R
Y
L
E
S
R
---------
N
-------------------------------
D
D
-
S
P
Y
L
F
V
E
M
K
R
K
R
---------
K
-------
D
K
-
L
S
P
K
-----
T
V
W
R
L
V
K
K
-------
Y
G
-----
R
K
A
G
V
------
E
L
-
T
--
P
H
Q
L
R
H
S
F
A
T
H
M
L
E
R
G
I
D
I
R
I
I
Q
E
L
L
G
H
-----
T
-
Q
I
Y
T
---
K
V
S
T
K
H
L
K
-
E
-
A
V
K
K
A
K
L
V
--------------------------------------------------
10
PsiBlast_PDB
64.12
22%
-76
- C5 -
-
4A8E
1
XERA_PYRAB
A:
[61-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
K
---
G
---
Y
S
T
R
S
L
N
L
V
I
Q
A
L
K
A
Y
F
K
F
E
G
L
D
-------
S
E
A
E
K
L
-----
K
T
P
K
M
-------
P
K
T
L
P
K
S
L
T
-
E
E
E
V
R
R
I
I
N
A
--------------------
A
E
--
T
L
R
D
R
L
----
I
L
L
L
L
Y
G
A
------
G
L
R
----------------------------
V
S
E
L
C
N
L
R
V
E
D
V
---------
N
F
E
Y
-
G
V
I
V
V
R
G
G
------------------------------------------------
K
G
-
G
K
D
R
V
V
-------
P
I
S
E
S
-------
L
L
S
E
I
---------
K
R
--------------
Y
-------------------------------
L
E
-
S
R
N
----
D
D
S
-
P
---------
Y
-------
L
F
-
V
E
M
K
RK
R
K
D
K
L
S
P
K
T
V
W
-------
R
L
V
K
K
Y
G
R
K
A
G
V
-
E
----
L
T
-
P
---
H
Q
L
R
H
S
F
A
T
H
M
L
E
R
G
I
D
I
R
I
I
Q
E
L
L
G
H
------
T
Q
I
Y
T
---
K
-
V
S
T
K
H
L
K
E
-
A
V
K
K
----
A
K
L
V
----------------------------------------------
30
HHSearch
63.82
18%
29
- C5 -
-
1Z19
2
VINT_LAMBD
B:
[1-276]
-----------------------------------------------------------------------------------------------------------------------
M
T
L
H
S
W
L
D
R
Y
E
K
I
L
A
S
R
G-
I
K
-----
Q
K
T
L
I
N
Y
M
S
K
I
--
K
A
-
I
R
R
G
L
P
D
----------
A
P
L
E
D
I
T
T
K
E
I
A
A
M
L
N
G
Y
-
I
---
D
E--
G
K
A
A
S
A
K
L
I
R
S
T
L
S
D
A
F
R
E
A
I
A
E
G
H
I
T
--
T
N
H
V
A
A
T
-----
R
A
A
K
S
--------
K
V
R
R
S
R
L
T
-
A
D
E
Y
L
K
I
Y
Q
A
A
------
E
S
S
--------------
P
C
W
L
R
L
----
A
M
E
L
A
V
V
T
------
G
Q
R
----------------------------
V
G
D
L
C
E
M
K
W
S
D
I
---------
V
--
D
-
G
Y
L
Y
V
E
Q
------------------------------------------------
S
K
T
-
G
V
K
I
A
I
-------
P
T
A
L
H
IDALGIS
M
K
E
T
L
---------
D
K
C
K
E
I
------------------------------------------
L
G
-
G
E
T
I
I
A
S
-
T
R
-
R
---------
E
-------
P
L
--
S
S
G
-----
T
V
S
R
Y
F
M
R
-------
A
R
-----
K
A
S
G
L
-
S
FEGD
P
P
-
T
--
F
H
E
L
R
S
L
S
A
R
-
L
Y
E
K
Q
I
S
D
K
F
A
Q
H
L
L
G
H
K
S
D
T
M
A
-
S
Q
Y
R
---
D
D
R
G
R
E
---------------------------------------------------------------
40
HHSearch
63.75
19%
-5
- C5 -
-
5JJV
4
XERH_HELPY
B:
[56-352]
---------------------------------------------------------------------------------------------------------------------------
S
Q
L
E
K
V
C
K
K
A
R
-
N
--
A
G
-----
L
L
G
I
N
T
Y
A
L
P
L
--
L
K
-
F
H
E
Y
F
S
K
A
R
L
I
T
ERLAF
N
S
L
K
N
I
D
E
V
M
L
A
E
F
L
S
V
Y
-
T
G--
G
---
L
S
L
A
T
K
K
N
Y
R
I
A
L
L
G
L
F
S
Y
I
D
K
Q
N
Q
D
E
NE
K
S
Y
I
Y
N
I
T
L
K
N
I
S
-----------
G
N
K
L
P
T
H
L
N
-
N
E
E
L
E
K
F
L
E
S
I
------
D
K
I
E
M
S
A------
K
V
--
R
A
R
N
R
L
----
L
I
K
I
I
V
F
T
------
G
M
R
----------------------------
S
N
E
A
L
Q
L
K
I
K
D
F
---------
T
L
E
N
-
G
C
Y
T
I
L
I
-----------------------------------------------
K
G
K
G
-
D
K
Y
R
A
V
-------
M
L
K
A
F
H------
I
E
S
L
L
---------
K
E
W
L
I
E
R
---------
E
L
YP----------------------------
V
K
-
N
D
L
L
F
C
N
Q
-
K
-
G
---------
S
-------
A
--
L
T
Q
A
-----
Y
L
Y
K
Q
V
E
R
-------
I
I
-----
N
F
A
G
L
-
R
RE--
K
N
-
G
--
A
H
M
L
R
H
S
F
A
T
L
L
Y
Q
K
R
H
D
L
I
L
V
Q
E
A
L
G
H
A
S
L
N
T
S
-
R
I
Y
T
---
H
F
D
K
Q
R
---------------------------------------------------------------
37
HHSearch
60.61
19%
13
- C5 -
-
5HXY
-
?
B:
[38-306]
------------------------------------------------------------------------------------------------------------------------
E
T
N
E
Y
L
S
R
F
V
E
Y
M
T
-
G
E
R
K
S
-----
R
Y
T
I
K
E
Y
R
F
L
V
--
D
Q
-
F
L
S
F
M
-
N
----------
K
K
P
D
E
I
T
P
M
D
I
E
R
Y
K
N
F
L
-
A
VKK
R
---
Y
S
K
T
S
Q
Y
L
A
I
K
A
V
K
L
F
Y
K
A
L
D
L
R
-------
V
P
I
N
L
------
T
P
P
---------
P
S
H
M
P
V
Y
L
S
-
E
D
E
A
K
R
L
I
E
A
A
------
S
S
---------------
D
T
R
M
Y
A
----
I
V
S
V
L
A
Y
T
------
G
V
R
----------------------------
V
G
E
L
C
N
L
K
I
S
D
V
---------
D
L
Q
E
-
S
I
I
N
V
R
------------------------------------------------
S
----
D
K
D
R
I
V
-------
I
M
A
E
E
-------
C
V
K
A
L
---------
G
S
Y
L
D
L
R
---------
L
S
MD----------------------------
T
D
-
N
D
Y
L
F
V
S
N
-
R
-
R
---------
V
-------
R
--
F
D
T
S
-----
T
I
E
R
M
I
R
D
-------
L
G
-----
K
K
A
G
I
-
Q
K---
K
V
-
T
--
P
H
V
L
R
H
T
F
A
T
S
V
L
R
N
G
G
D
I
R
F
I
Q
Q
I
L
G
H
A
S
V
A
T
T
-
Q
I
Y
T
---
H
L
N
D
S
A
L
--------------------------------------------------------------
43
HHSearch
59.99
21%
-5
- C5 -
-
3NKH
2
?
A:
[21-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
N
A
Y
L
E
-
L
N
E
I
E
S
I
I
K
D
I
------
N
T
K
A
Q
K
MHS
G
I
H
K
R
F
--
Y
L
F
V
A
L
----
M
T
E
F
Q
A
L
N
------
G
M
R
----------------------------
I
G
E
M
L
A
I
Q
N
E
D
I
---------
D
F
D
N
-
K
S
L
N
I
N
G
T
I
H
W
---------
F
HDESGG
F
G
V
K
----------------------
D
T
T
---
S
S
Y
R
T
I
-------
G
L
S
S
R
-------
S
C
E
I
L
---------
K
K
A
I
L
E
N
---------
K
K
D
S
K
WNDGY----------------------
L
N
-
R
N
F
V
F
T
N
H
-
K
-
G
---------
N
-------
P
--
M
Q
T
E
-----
R
F
N
K
I
L
R
E
-------
A
A
-----
K
D
V
G
I
-
D
K---
E
V
-
S
--
S
H
I
L
R
H
S
H
I
S
L
L
S
Q
Q
G
V
S
L
K
A
I
M
D
R
V
G
H
S
D
H
R
T
T
L
S
I
Y
S
---
H
V
T
E
Q
M
-
D
K
D
-
M
M
N
K
L
E
----------------------------------------------------
27
Fugue
59.98
19%
30
- C1 -
-
5J67
9
ASTN2_HUMAN
A:
[1-572]
K
F
N
D
T
L
F
G
E
M
L
H
G
Y
N
N
R
T
Q
H
V
NQGQV
F
Q
M
T
F
R
E
N
N
F
I
K
D
F
P
QLADG
L
L
V
I
P
L
P
V
E
E
Q
C
R
G
V
L
S
E
P
L
P
D
L
Q
L
L
T
GDIRYDEAMG
Y
P
M
V
Q
Q
W
R
V
R
S
N
L
Y
R
V
K
L
S
T
I
T
L
A
A
G
F
T
N
V
L
K
I
L
T
K
E
S
S
R
E
E
L
L
S
F
I
Q
H
Y
G
-
S
--
H
Y
IA
E
A
L
Y
G
S
E
L
T
C
I
I
H
F
PS
K
K
V
Q
Q
Q
L
W
L
Q
----------
Y
Q
K
E
T
-
T
S
M
P
F
I
T
Y
L
S
G
L
-
L
---
T
---
A
Q
-
M
L
S
D
D
Q
L
I
S
--
G
V
-
E
I
R
C
E
E
K
G
R
C
--
P
S
T
C
H
L
C
-----
R
R
P
G
K
-------
E
Q
L
S
P
T
P
V
L
L
E
I
N
R
V
V
P
L
Y
T
L
IQD
N
G
T
K
E
A
F
K
--------
S
A
--
L
M
S
S
Y
W
CSGK
G
D
V
I
D
D
W
C
------
R
C
D
LSAFDANGLPNCSPL
L
Q
P
V
L
R
L
SPTVEP
S
S
T
V
V
S
L
E
W
V
D
V
QPAIGTKVS
D
Y
I
L
-
Q
H
K
K
V
D
T
D
L
Y
T
---------
G
-------
E
F
L
S
FADDLLSGLGTSC
V
A
A
G
R
S
H
G
E
V
P
E
V
-
S
I
Y
S
V
I
F
K
CLEPD
G
L
Y
K
F
-------
T
L
Y
A
V
D
TR
G
R
H
S
E
L
S
T
V
T
L
R
T
---------
A
CPLV---------------------------
D
D
-
N
K
A
E
E
I
A
D
K
I
-
Y
---------
N
-------
L
Y
-
N
G
Y
T
-----
S
G
K
E
Q
Q
M
A
-------
Y
N
-----
T
L
M
E
V
-
S
----
A
S
-
M
--
L
F
R
V
Q
H
H
Y
N
S
H
Y
E
K
F
G
D
F
V
W
R
S
E
D
E
L
G
P
R
-
K
A
H
L
I
L
R
R
L
---
E
R
V
S
S
H
C
S
S
L
L
R
S
A
Y
I
Q
S
R
V
E
T
V
P
Y
L
F
C
R
S
E
E
V
R
P
A
G
MVWYSILKDT
K
I
T
C
E
E
K
M
V
S
M
A
R
N
T
Y
GESKGR
25
Fugue
59.03
13%
-66
- C5 -
-
2A3V
-
?
A:
[2-320]
--------------------------------------------------------------
G
S
Q
F
L
L
S
V
R
------------
E
F
M
Q
T
-----------------------
R
Y
Y
A
K
K
T
I
E
A
Y
L
H
W
I
T
R
Y
I
H
F
H
N
-
K
--
K
H
-------------------------
P
S
L
----------
M
G
D
K
E
V
E
E
F
L
T
Y
L
A
V
Q
G
K
-
V
--------
A
T
K
T
Q
S
L
A
L
N
S
L
S
F
L
Y
K
E
I
L
K
T
P
L
-----
S
L
E
I
R
F
-----
Q
R
S
Q
L
-------
E
R
K
L
P
V
V
L
T
-
R
D
E
I
R
R
L
L
E
I
V
------
D
-----------------
P
K
H
Q
L
----
P
I
K
L
L
Y
G
S
------
G
L
R
----------------------------
L
M
E
C
M
R
L
R
V
Q
D
I
---------
D
F
D
Y
-
G
A
I
R
I
W
Q
G
K
-----------
G
-------
G
K
N
----------------------
R
T
V
T
L
-
A
K
E
L
Y
P
-------
H
L
K
E
Q
-------
I
A
L
A
K
---------
R
Y
Y
D
R
D
L
---------
H
-------------------------------
Q
K
N
Y
G
G
V
W
L
P
T
A
L
-
K
---------
E
-------
K
Y
P
N
A
P
Y
-----
E
F
R
W
H
Y
L
F
-------
P
S
-----
F
Q
L
S
L
-
D
----
P
E
-
S
--
D
V
M
R
R
H
H
M
N
E
T
V
L
Q
K
A
V
R
R
S
A
Q
E
A
G
I
E
K
T
-
V
T
C
H
T
L
R
H
S
F
A
T
H
L
L
E
V
G
A
D
I
R
-
T
V
Q
E
Q
L
G
H
T
D
V
K
T
T
Q
I
Y
T
H
S
G
V
LSPLSRL-----------------------------
48
HHSearch
58.96
28%
-146
* C5 *
-
1AIH
-
VINT_BPHC1
A:
[4-155]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
L
Y
-
E
R
D
I
Y
R
L
L
A
E
C
------
D
N
S
R
-------------
N
P
D
L
G
L
----
I
V
R
I
C
L
A
T
------
G
A
R
----------------------------
W
S
E
A
E
T
L
T
Q
S
Q
V
---------
M
P
Y
---
K
I
T
F
T
------------------------------------------------
N
T
K
S
-
K
K
N
R
T
V
-------
P
I
S
D
E
-------
L
F
D
M
L
---------
P
K
K
------------------------------------------------
R
G
R
L
F
N
D
A
-----------------------------------
Y
E
S
F
E
N
-------
A
V
-----
L
R
A
E
I
-
E
L
P
K-
G
Q
-
L
--
T
H
V
L
R
H
T
F
A
S
H
F
M
M
N
G
G
N
I
L
V
L
K
E
I
L
G
H
S
T
I
E
M
T
-
M
R
Y
A
---
H
F
A
P
S
H
---------------------------------------------------------------
49
HHSearch
58.37
28%
-144
- C5 -
-
1AIH
-
VINT_BPHC1
C:
[4-155]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
L
Y
-
E
R
D
I
Y
R
L
L
A
E
C
------
D
N
S
R
-------------
N
P
D
L
G
L
----
I
V
R
I
C
L
A
T
------
G
A
R
----------------------------
W
S
E
A
E
T
L
T
Q
S
Q
V
---------
M
P
Y
---
K
I
T
F
T
------------------------------------------------
N
T
K
S
-
K
K
N
R
T
V
-------
P
I
S
D
E
-------
L
F
D
M
L
---------
P
K
K
------------------------------------------------
R
G
R
L
F
N
D
A
-----------------------------------
Y
E
S
F
E
N
-------
A
V
-----
L
R
A
E
I
-
E
LPK-
G
Q
-
L
--
T
H
V
L
R
H
T
F
A
S
H
F
M
M
N
G
G
N
I
L
V
L
K
E
I
L
G
H
S
T
I
E
M
T
-
M
R
Y
A
---
H
F
A
P
S
H
---------------------------------------------------------------
44
HHSearch
56.77
21%
-3
- C5 -
-
3NKH
3
?
B:
[21-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
N
A
Y
L
E
-
L
N
E
I
E
S
I
I
K
D
I
------
N
T
K
A
Q
K
MHS
G
I
H
K
R
F
--
Y
L
F
V
A
L
----
M
T
E
F
Q
A
L
N
------
G
M
R
----------------------------
I
G
E
M
L
A
I
Q
N
E
D
I
---------
D
F
D
N
-
K
S
L
N
I
N
G
T
I
H
W
---------
F
HDESGG
F
G
V
K
----------------------
D
T
T
K
T
E
S
S
Y
R
T
I
-------
G
L
S
S
R
-------
S
C
E
I
L
---------
K
K
A
I
L
E
N
---------
K
K
D
S
K
WNDGY----------------------
L
N
-
R
N
F
V
F
T
N
H
-
K
-
G
---------
N
-------
P
--
M
Q
T
E
-----
R
F
N
K
I
L
R
E
-------
A
A
-----
K
D
V
G
I
-
D
K---
E
V
-
S
--
S
H
I
L
R
H
S
H
I
S
L
L
S
Q
Q
G
V
S
L
K
A
I
M
D
R
V
G
H
S
D
H
R
T
T
L
S
I
Y
S
---
H
V
T
E
Q
M
-
D
K
D
-
M
M
N
K
L
E
----------------------------------------------------
47
HHSearch
55.20
20%
-140
- C5 -
-
5DOR
-
VINT_BPP2
A:
[2-157]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
L
T
-
Q
E
E
I
A
L
L
L
A
A
L
------
D
G
-----------------
D
N
K
K
----
I
A
I
L
C
L
S
T
------
G
A
R
----------------------------
W
G
E
A
A
R
L
K
A
E
N
I
---------
I
H
N
---
R
V
T
F
V
------------------------------------------------
K
--
T
-
N
K
P
R
T
V
-------
P
I
S
E
A
-------
V
A
K
M
I
---------
A
D
--------------------------------------------------
G
F
L
F
P
D
A
-
D
------------------------
Y
P
-----
R
F
R
R
T
M
K
A
-------
I
K
-----
P
D
L
P
M
------
G
Q
-
A
--
T
H
A
L
R
H
S
F
A
T
H
F
M
I
N
G
G
S
I
I
T
L
Q
R
I
L
G
H
T
R
I
E
Q
T
-
M
V
Y
A
---
H
F
A
P
E
Y
-
L
Q
D
-
A
I
S
L
------------------------------------------------------
36
HHSearch
54.44
19%
38
- C5 -
-
5HXY
-
?
E:
[38-307]
------------------------------------------------------------------------------------------------------------------------
E
T
N
E
Y
L
S
R
F
V
E
Y
M
T
-
G
ER
K
S
-----
R
Y
T
I
K
E
Y
R
F
L
V
--
D
Q
-
F
L
S
F
M
-
N
----------
K
K
P
D
E
I
T
P
M
D
I
E
R
Y
K
N
F
L
-
A
VKK
R
---
Y
S
K
T
S
Q
Y
L
A
I
K
A
V
K
L
F
Y
K
A
L
D
L
R
-------
V
P
I
N
L
------
T
P
P
K
R
-------
P
S
H
M
P
V
Y
L
S
-
E
D
E
A
K
R
L
I
E
A
A
------
S
S
---------------
D
T
R
-
Y
A
----
I
V
S
V
L
A
Y
T
------
G
V
R
----------------------------
V
G
E
L
C
N
L
K
I
S
D
V
---------
D
L
Q
E
-
S
I
I
N
V
R
------------------------------------------------
S
G
K
G
-
D
K
D
R
I
V
-------
I
-
A
E
E
-------
C
V
K
A
L
---------
G
S
Y
L
D
L
R
---------
L
SD-----------------------------
T
D
-
N
D
Y
L
F
V
S
N
-
R
-
R
---------
V
-------
R
--
F
D
T
S
-----
T
I
E
R
-
I
R
D
-------
L
G
-----
K
K
A
G
I
-
Q
K---
K
V
-
T
--
P
H
V
L
R
H
T
F
A
T
S
V
L
R
N
G
G
D
I
R
F
I
Q
Q
I
L
G
H
A
S
V
A
T
T
-
Q
I
Y
T
---
H
L
N
D
S
A
L
--------------------------------------------------------------
11
PsiBlast_PDB
53.19
23%
33
- C5 -
-
3NKH
1
?
A:
[53-214]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
----
Y
L
F
V
A
L
M
T
E
F
Q
A
L
N
G
M
R
----------------------------
I
G
E
M
L
A
I
Q
N
E
D
I
---------
D
F
D
N
-
K
S
L
N
I
N
-
G
T
I
H
WFHDESGG
F
G
-------
V
K
D
----------------------
T
T
----
S
S
Y
R
T
I
-------
G
L
S
S
R
-------
S
C
E
I
L
---------
K
K
A
I
L
E
N
K
K
D
S
K
WNDG
Y
-------------------------------
L
N
-
R
N
F
V
F
-
T
N
H
K
-
G
---------
N
-------
P
M
-
Q
T
E
R
------
F
N
K
I
L
R
E
-------
A
A
-----
K
D
V
G
I
D
K
----
E
V
-
S
--
S
H
I
L
R
H
S
H
I
S
L
L
S
Q
Q
G
V
S
L
K
A
I
M
D
R
V
G
H
S
----------------------------------------------------------------------------------
2
PsiBlast_PDB
52.76
26%
-91
- C5 -
-
5HXY
-
?
A:
[158-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
----
I
V
S
V
L
A
Y
T
------
G
V
R
----------------------------
V
G
E
L
C
N
L
K
I
S
D
V
---------
D
L
Q
E
-
S
I
I
N
V
R
S
G
------------------------------------------------
K
G
-
D
K
D
R
I
V
-------
I
M
A
E
E
C
V
K
----
A
L
G
S
Y
---------
L
D
L
R
L
S
M
---------
D
-------------------------------
T
D
-
N
D
Y
L
F
V
S
N
R
R
-
V
---------
R
--------
F
-
D
T
-------
S
T
I
E
R
M
I
R
-------
D
L
G
----
K
K
A
G
I
-
Q
----
K
K
V
T
--
P
H
V
L
R
H
T
F
A
T
S
V
L
R
N
G
G
D
I
R
F
I
Q
Q
I
L
G
H
A
-
S
V
A
T
T
Q
I
Y
T
---
H
L
N
D
S
----------------------------------------------------------------
34
HHSearch
50.48
13%
-5
- C5 -
-
1CRX
3
RECR_BPP1
A:
[6-318]
--------------------------------------------------------------------------------------------------------------------------
K
N
L
M
D
M
F
R
D
R
Q
A
----
F
S
-----
E
H
T
W
K
M
L
L
S
V
C
--
R
S
W
-
A
A
W
C
K
L
N
N--------
R
K
W
F
P
A
E
P
E
D
V
R
D
Y
L
L
Y
L
-
Q
A
R
-
G
---
L
A
V
K
T
I
Q
Q
H
L
G
Q
L
N
M
L
H
R
R
S
G
L
P
R
P
S
D
--
S
N
A
V
S
L
V
M
R
R
I
-
R
K
E
N
V
D
A
G
E
R
A
K
Q
A
L
A
F
E
R
T
D
-
F
D
Q
V
R
S
L
M
E
N
S
------
D
R
C
Q
-------------
D
I
R
N
L
A
----
F
L
G
I
A
Y
N
T
------
L
L
R
----------------------------
I
A
E
I
A
R
I
R
V
K
D
I
---------
S
R
T
D
G
G
R
M
L
I
H
I
G
R
T
-------------------------------------------
K
T
L
V
S
-
T
A
G
V
E
K
-------
A
L
S
L
G
-------
V
T
K
L
V
---------
E
R
W
I
S
V
S
---------
G
VAD----------------------------
D
P
-
N
N
Y
L
F
C
R
V
R
K
-
N
---------
G
V
A
A
P
S
AT
S
Q
-
L
S
T
R
-----
A
L
E
G
I
F
E
A
T
H
R
L
I
YG
A
K
-----
D
D
S
G
Q
-
R
YL--
A
W
-
S
--
G
H
S
A
R
V
G
A
A
R
D
M
A
R
A
G
V
S
I
P
E
I
M
Q
A
G
G
W
T
N
V
N
I
V
-
M
N
Y
I
---
R
N
L
D
S
E
T
-
G
A
-
M
V
R
-------------------------------------------------------