@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL23: (2017-10-30 )
MNQVELIQALPKAELHVHIEGTFEPELMFAIAQRNQIQIPYKSVEEVKQAYNFHNLQSFLDIYYAGANVLVHEQDFYDLAWAYFEKCAEDRVVHTEMFFDPQTHTDRGIAFATVINGLKRACADAKDKFGISSQLIMCFLRHLSEEAAFETLEQALPFKEDIIAVGLDSSEVGHPPAKFERVFAKAREEGFLIVAHAGEEGPPEYVWEALDLLKVNRIDHGVRSEEDEQLMARLINEKMPLTVCPLSNLKLCVVKDMKDHNIRRLLQKGVHVTVNSDDPSYFGGYMNDNFFAIQQALDLTNDELKQLAINSFEASFISDEEKQKWISEIQKI
Atome Classification :
(20 SA)
.........10........20........30........40......-----..50--.---...---.....60..-......70.-........80........90........100------------.------------..-.------------.--..110.......120.......130.......140.......150......-.-160...-.....170...---..---..180-.........190.......200-.-......210.......220.......230.......240.......250....---...260.......270.......280.......290.......300.......310.......320.......330--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
Q
V
E
L
I
Q
ALPKA
E
L
H
V
H
I
EGTFE
P
E
L
M
F
A
IAQR
N
Q
I
QIP
Y
K
S
V
E
E
V
-----
K
Q
A
---
Y
---
N
F
H
---
N
L
Q
S
F
L
D
I
Y
-YAG
A
N
V
L
-
V
-HEQ
D
F
Y
D
L
A
W
A
Y
F
E
K
CAED
R
V
V
H
T
E
M
F
FDPQ------------T------------HT-D------------R--
G
I
A
F
A
T
V
I
N
G
L
K
R
A
C
A
D
A
K
D
KFG
I
S
S
Q
L
I
M
C
F
L
R
H
L
S
E
E
A
A
F
E
T
L
E
Q
ALPF-K-E
D
-
I
I
A
-VGLDSSEVGHP---
P
A
---
K
F
E
---
R
V
F
A
K
AREE
G
F
L
I
V
A
HAGEEG
P
-
P
-
E
Y
V
W
E
A
L
D
L
L
K
V
N
R
IDHGVRSE
E
D
E
Q
L
M
A
R
L
INEKM
P
L
T
V
CPLSN
L
K
L
C
V
VKD---MK
D
H
N
I
R
R
L
L
Q
KG
V
H
V
T
VNSDDP
S
Y
FGGYMND
N
F
F
A
I
Q
Q
A
L
DL
T
N
D
E
L
K
Q
L
A
I
N
SF
E
A
S
FIS
D
E
E
K
Q
K
W
I
S
E
I
QKI--
26
HHSearch
98.63
63%
-93
- C1 -
-
3PAO
1
ADE_PSEAE
A:
[4-316]
---
Y
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
-----
R
K
A
---
Y
---
A
F
N
---
N
L
Q
E
F
L
D
L
Y
-
Y
A
G
A
D
V
L
-
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
-
D
------------
R
--
G
I
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
-
R
-
D
A
-
F
I
A
-
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
-
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
3
PsiBlast_PDB
98.54
63%
-93
- C1 -
-
3PAO
1
ADE_PSEAE
A:
[5-316]
----
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
-----
R
K
A
---
Y
---
A
F
N
---
N
L
Q
E
F
L
D
L
Y
-
Y
A
G
A
D
V
L
-
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
-
D
------------
R
--
G
I
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
-
R
-
D
A
-
F
I
A
-
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
-
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
2
PsiBlast_PDB
97.48
63%
-92
- C1 -
-
3PAN
1
ADE_PSEAE
A:
[5-316]
----
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
-----
R
K
A
---
Y
---
A
F
N
---
N
L
Q
E
F
L
D
L
Y
-
Y
A
G
A
D
V
L
-
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
-
D
------------
R
--
G
I
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
-
R
-
D
A
-
F
I
A
-
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
-
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
1
PsiBlast_PDB
97.19
63%
-90
- C1 -
-
3OU8
-
ADE_PSEAE
A:
[5-316]
----
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
-----
R
K
A
---
Y
---
A
F
N
---
N
L
Q
E
F
L
D
L
Y
-
Y
A
G
A
D
V
L
-
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
-
D
------------
R
--
G
I
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
-
R
-
D
A
-
F
I
A
-
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
-
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
27
HHSearch
96.54
63%
-89
- C1 -
-
3PBM
1
ADE_PSEAE
B:
[4-317]
---
Y
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
-----
R
K
A
---
Y
---
A
F
N
---
N
L
Q
E
F
L
D
L
Y
-
Y
A
G
A
D
V
L
-
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
-
D
------------
R
--
G
I
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
-
R
-
D
A
-
F
I
A
-
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
-
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
V
-----------------
4
PsiBlast_PDB
95.56
63%
-91
- C1 -
-
3PBM
1
ADE_PSEAE
A:
[5-316]
----
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
-----
R
K
A
---
Y
---
A
F
N
---
N
L
Q
E
F
L
D
L
Y
-
Y
A
G
A
D
V
L
-
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
-
D
------------
R
--
G
I
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
-
R
-
D
A
-
F
I
A
-
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
-
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
21
PsiBlast_CBE
93.48
50%
-98
- C1 -
-
3RYS
1
?
B:
[12-334]
--------
A
P
P
V
A
E
L
H
L
H
I
E
G
T
L
Q
P
E
L
I
F
A
L
A
E
R
N
G
I
E
L
P
Y
E
D
I
E
E
L
-----
R
E
K
---
Y
---
E
F
T
---
D
L
Q
S
F
L
D
L
Y
-
Y
A
N
M
A
V
L
-
Q
-
T
E
Q
D
F
T
D
M
T
R
A
Y
L
E
R
A
A
A
G
G
V
R
H
A
E
I
M
M
D
P
Q
------------
A
------------
H
T
-
S
------------
R
--
G
V
A
L
E
T
C
V
N
G
V
A
N
A
L
A
T
S
E
E
D
F
G
V
S
T
L
L
I
A
A
F
L
R
D
M
S
E
D
S
A
L
E
V
L
D
Q
L
L
A
M
-
H
-
A
P
-
I
A
G
-
I
G
L
D
S
A
E
V
G
N
P
---
P
S
---
K
F
E
---
R
L
Y
Q
R
A
A
E
A
G
L
R
R
I
A
H
A
G
E
E
G
P
-
A
-
S
Y
I
T
E
A
L
D
V
L
H
V
E
R
I
D
H
G
I
R
C
M
E
D
T
D
V
V
Q
R
L
V
A
E
Q
V
P
L
T
V
C
P
L
S
N
V
R
L
R
A
V
D
K
---
L
A
D
H
P
L
P
E
M
L
A
I
G
L
N
V
C
V
N
S
D
D
P
A
Y
F
G
G
Y
V
D
D
N
F
E
Q
L
V
K
V
L
E
F
S
V
P
E
Q
A
T
L
A
A
N
S
I
R
S
S
F
A
S
D
A
R
K
A
V
L
L
D
E
V
T
E
---
30
HHSearch
93.25
49%
-95
- C1 -
-
3RYS
1
?
A:
[8-334]
----
T
T
S
T
A
P
P
V
A
E
L
H
L
H
I
E
G
T
L
Q
P
E
L
I
F
A
L
A
E
R
N
G
I
E
L
P
Y
E
D
I
E
E
L
-----
R
E
K
---
Y
---
E
F
T
---
D
L
Q
S
F
L
D
L
Y
-
Y
A
N
M
A
V
L
-
Q
-
T
E
Q
D
F
T
D
M
T
R
A
Y
L
E
R
A
A
A
G
G
V
R
H
A
E
I
M
M
D
P
Q
------------
A
------------
H
T
-
S
------------
R
--
G
V
A
L
E
T
C
V
N
G
V
A
N
A
L
A
T
S
E
E
D
F
G
V
S
T
L
L
I
A
A
F
L
R
D
M
S
E
D
S
A
L
E
V
L
D
Q
L
L
A
M
-
H
-
A
P
-
I
A
G
-
I
G
L
D
S
A
E
V
G
N
P
---
P
S
---
K
F
E
---
R
L
Y
Q
R
A
A
E
A
G
L
R
R
I
A
H
A
G
E
E
G
P
-
A
-
S
Y
I
T
E
A
L
D
V
L
H
V
E
R
I
D
H
G
I
R
C
M
E
D
T
D
V
V
Q
R
L
V
A
E
Q
V
P
L
T
V
C
P
L
S
N
V
R
L
R
A
V
D
K
---
L
A
D
H
P
L
P
E
M
L
A
I
G
L
N
V
C
V
N
S
D
D
P
A
Y
F
G
G
Y
V
D
D
N
F
E
Q
L
V
K
V
L
E
F
S
V
P
E
Q
A
T
L
A
A
N
S
I
R
S
S
F
A
S
D
A
R
K
A
V
L
L
D
E
V
T
E
---
5
PsiBlast_PDB
93.05
50%
-96
- C1 -
-
3RYS
1
?
A:
[12-334]
--------
A
P
P
V
A
E
L
H
L
H
I
E
G
T
L
Q
P
E
L
I
F
A
L
A
E
R
N
G
I
E
L
P
Y
E
D
I
E
E
L
-----
R
E
K
---
Y
---
E
F
T
---
D
L
Q
S
F
L
D
L
Y
-
Y
A
N
M
A
V
L
-
Q
-
T
E
Q
D
F
T
D
M
T
R
A
Y
L
E
R
A
A
A
G
G
V
R
H
A
E
I
M
M
D
P
Q
------------
A
------------
H
T
-
S
------------
R
--
G
V
A
L
E
T
C
V
N
G
V
A
N
A
L
A
T
S
E
E
D
F
G
V
S
T
L
L
I
A
A
F
L
R
D
M
S
E
D
S
A
L
E
V
L
D
Q
L
L
A
M
-
H
-
A
P
-
I
A
G
-
I
G
L
D
S
A
E
V
G
N
P
---
P
S
---
K
F
E
---
R
L
Y
Q
R
A
A
E
A
G
L
R
R
I
A
H
A
G
E
E
G
P
-
A
-
S
Y
I
T
E
A
L
D
V
L
H
V
E
R
I
D
H
G
I
R
C
M
E
D
T
D
V
V
Q
R
L
V
A
E
Q
V
P
L
T
V
C
P
L
S
N
V
R
L
R
A
V
D
K
---
L
A
D
H
P
L
P
E
M
L
A
I
G
L
N
V
C
V
N
S
D
D
P
A
Y
F
G
G
Y
V
D
D
N
F
E
Q
L
V
K
V
L
E
F
S
V
P
E
Q
A
T
L
A
A
N
S
I
R
S
S
F
A
S
D
A
R
K
A
V
L
L
D
E
V
T
E
---
44
Fugue
69.68
27%
12
- C1 -
-
1A4M
1
ADA_MOUSE
A:
[1-349]
----
T
P
A
F
N
K
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
-----
R
N
I
---
I
G
MD
K
P
L
---
S
L
P
G
F
L
A
K
F
-
D
Y
Y
M
P
V
I
-
A
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
------------
L
LANSKVDPMPWN
Q
T
-
E
------------
G
--
D
V
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
S
L
E
V
L
E
L
C
K
K
Y
-
N
-
Q
K
T
V
V
A
-
M
D
L
A
G
D
E
T
I
E
G
---
S
S
LF
P
G
H
V
---
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
E
E
K
K
E
L
L
E
R
L
Y
R
E
Y
Q
24
HHSearch
68.31
26%
1
- C1 -
-
4GXW
-
?
A:
[21-354]
-
A
H
R
A
F
F
H
A
L
P
K
V
E
L
H
C
H
L
L
G
A
V
R
H
D
T
F
V
A
L
A
Q
R
S
G
A
P
I
E
R
A
E
I
D
A
F
-----
Y
A
R
G--
E
---
K
P
V
---
G
V
L
H
V
L
R
A
L
-
D
R
Y
--
L
L
-
T
-
R
P
D
D
L
R
R
I
A
Y
E
Y
L
E
D
A
A
A
H
N
V
R
H
A
E
F
F
W
N
P
T
------------
G
------------
T
V
R
V
------------
S
--
G
I
P
Y
A
D
A
Q
A
A
I
V
T
G
M
R
D
A
A
R
D
F
G
I
G
A
R
L
I
P
S
I
D
R
E
Q
D
P
D
E
A
V
A
I
V
D
W
M
K
A
N
-
R
A
D
E
-
V
A
G
-
I
G
I
D
Y
R
E
N
D
R
P
---
P
E
---
L
F
W
---
K
A
Y
R
D
A
R
A
A
G
F
R
T
T
A
H
A
G
E
F
G
M
P
W
-
R
N
V
E
T
A
V
D
L
L
H
V
D
R
V
D
H
G
Y
T
I
V
D
N
P
E
L
C
A
R
Y
A
E
R
G
I
V
F
T
V
V
P
T
N
S
Y
Y
L
R
T
L
P
P
DQW
A
E
R
H
P
M
R
K
M
P
G
L
G
L
K
I
H
P
N
T
D
D
P
T
L
H
K
V
N
P
S
E
A
W
E
L
M
F
S
H
F
G
F
T
I
A
D
L
K
Q
F
M
L
N
G
I
D
G
A
W
V
D
D
D
T
K
A
A
W
R
A
A
W
A
----
22
HHSearch
68.23
27%
7
- C1 -
-
1ADD
1
ADA_MOUSE
A:
[1-345]
----
T
P
A
F
N
K
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
-----
R
N
I
I
G
M
D
---
K
P
L
---
S
L
P
G
F
L
A
K
F
-
D
Y
Y
M
P
V
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
------------
L
------------
L
A
-
N
SKVDPMPWNQTE
G
--
D
V
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
Q
P
S
-
W
S
L
E
V
L
E
L
C
K
K
Y
-
N
Q
K
T
-
V
V
A
-
M
D
L
A
G
D
E
T
I
E
G
SSL
F
P
---
G
H
V
---
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
E
E
K
K
E
L
L
E
R
L
Y
----
25
HHSearch
66.40
26%
1
- C1 -
-
4GXW
-
?
B:
[21-354]
-
A
H
R
A
F
F
H
A
L
P
K
V
E
L
H
C
H
L
L
G
A
V
R
H
D
T
F
V
A
L
A
Q
R
S
G
A
P
I
E
R
A
E
I
D
A
F
-----
Y
A
R
G--
E
---
K
P
V
---
G
V
L
H
V
L
R
A
L
-
D
R
Y
--
L
L
-
T
-
R
P
D
D
L
R
R
I
A
Y
E
Y
L
E
D
A
A
A
H
N
V
R
H
A
E
F
F
W
N
P
T
------------
G
------------
T
V
R
V
------------
S
--
G
I
P
Y
A
D
A
Q
A
A
I
V
T
G
M
R
D
A
A
R
D
F
G
I
G
A
R
L
I
P
S
I
D
R
E
Q
D
P
D
E
A
V
A
I
V
D
W
M
K
A
N
-
R
A
D
E
-
V
A
G
-
I
G
I
D
Y
R
E
N
D
R
P
---
P
E
---
L
F
W
---
K
A
Y
R
D
A
R
A
A
G
F
R
T
T
A
H
A
G
E
F
G
M
P
W
-
R
N
V
E
T
A
V
D
L
L
H
V
D
R
V
D
H
G
Y
T
I
V
D
N
P
E
L
C
A
R
Y
A
E
R
G
I
V
F
T
V
V
P
T
N
S
Y
Y
L
R
T
L
P
P
DQW
A
E
R
H
P
M
R
K
M
P
G
L
G
L
K
I
H
P
N
T
D
D
P
T
L
H
K
V
N
P
S
E
A
W
E
L
M
F
S
H
F
G
F
T
I
A
D
L
K
Q
F
M
L
N
G
I
D
G
A
W
V
D
D
D
T
K
A
A
W
R
A
A
W
A
----
12
PsiBlast_PDB
65.57
29%
6
- C1 -
-
4GXW
-
?
A:
[25-349]
-----
F
F
H
A
L
P
K
V
E
L
H
C
H
L
L
G
A
V
R
H
D
T
F
V
A
L
A
Q
R
S
G
A
P
I
E
R
A
E
I
D
A
F
Y
ARGE
K
P
V
---
G
---
V
L
H
---
V
L
R
A
-
L
D
R
Y
------
L
L
-
T
-
R
P
D
D
L
R
R
I
A
Y
E
Y
L
E
D
A
A
A
H
N
V
R
H
A
E
F
F
W
N
P
-------------
T
------------
G
T
-
V
------------
R
VS
G
I
P
Y
A
D
A
Q
A
A
I
V
T
G
M
R
D
A
A
R
D
F
G
I
G
A
R
L
I
P
S
I
D
R
E
Q
D
P
D
E
A
V
A
I
V
D
W
M
K
A
N
-
R
-
A
D
-
E
V
A
G
I
G
I
D
Y
R
E
N
D
R
P
---
P
E
---
L
F
W
---
K
A
Y
R
D
A
R
A
A
G
F
R
T
T
A
H
A
G
E
F
G
M
-
P
W
R
N
V
E
T
A
V
D
L
L
H
V
D
R
V
D
H
G
Y
T
I
V
D
N
P
E
L
C
A
R
Y
A
E
R
G
I
V
F
T
V
V
P
T
N
S
Y
Y
L
R
T
L
P
P
DQW
A
E
R
H
P
M
R
K
M
P
G
L
G
L
K
I
H
P
N
T
D
D
P
T
L
H
K
V
N
P
S
E
A
W
E
L
M
F
S
H
F
G
F
T
I
A
D
L
K
Q
F
M
L
N
G
I
D
G
A
W
V
D
D
D
T
K
A
A
W
---------
10
PsiBlast_PDB
65.53
26%
8
- C1 -
-
3MVT
1
ADA_MOUSE
A:
[7-332]
----------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
-----
R
N
I
---
I
---
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
A
-
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
-
E
------------
G
--
D
V
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
S
L
E
V
L
E
L
C
K
K
Y
N
Q
-
K
T
-
V
V
A
-
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
8
PsiBlast_PDB
65.07
26%
4
- C1 -
-
1A4M
1
ADA_MOUSE
A:
[7-332]
----------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
-----
R
N
I
---
I
---
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
A
-
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
-
E
------------
G
--
D
V
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
S
L
E
V
L
E
L
C
K
K
Y
N
Q
-
K
T
-
V
V
A
-
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
11
PsiBlast_PDB
64.95
26%
7
- C1 -
-
3MVI
1
ADA_MOUSE
A:
[7-332]
----------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
-----
R
N
I
---
I
---
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
A
-
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
-
E
------------
G
--
D
V
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
S
L
E
V
L
E
L
C
K
K
Y
N
Q
-
K
T
-
V
V
A
-
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
7
PsiBlast_PDB
64.76
26%
3
- C1 -
-
1A4L
1
ADA_MOUSE
A:
[7-332]
----------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
-----
R
N
I
---
I
---
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
A
-
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
-
E
------------
G
--
D
V
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
S
L
E
V
L
E
L
C
K
K
Y
N
Q
-
K
T
-
V
V
A
-
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
6
PsiBlast_PDB
64.67
26%
4
- C1 -
-
2ADA
1
ADA_MOUSE
A:
[10-335]
----------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
-----
R
N
I
---
I
---
G
M
D
KPL
S
L
P
G
F
L
A
K
F
D
Y
Y
M
P
V
I
A
-
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
-
E
------------
G
--
D
V
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
S
L
E
V
L
E
L
C
K
K
Y
N
Q
-
K
T
-
V
V
A
-
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
-
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
-----------------
23
HHSearch
64.56
25%
11
- C1 -
-
3IAR
2
ADA_HUMAN
A:
[2-345]
-----
P
A
F
D
K
P
K
V
E
L
H
V
H
L
D
G
S
I
K
P
E
T
I
L
Y
Y
G
R
R
R
G
I
A
L
P
A
N
T
A
E
G
L
-----
L
N
V
IGM
D
---
K
P
L
---
T
L
P
D
F
L
A
K
F
-
D
Y
Y
M
P
A
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
------------
L
------------
L
A
-
N
SKVEPIPWNQAE
G
--
D
L
T
P
D
E
V
V
A
L
V
G
Q
G
L
Q
E
G
E
R
D
F
G
V
K
A
R
S
I
L
C
C
M
R
H
Q
P
N
W
-
S
P
K
V
V
E
L
C
K
K
Y
-
Q
Q
Q
T
-
V
V
A
-
I
D
L
A
G
D
E
T
I
P
G
SSL
L
P
---
G
H
V
---
Q
A
Y
Q
E
A
V
K
S
G
I
H
R
T
V
H
A
G
E
V
G
S
-
A
-
E
V
V
K
E
A
V
D
I
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
Q
A
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
---
D
T
E
H
A
V
I
R
L
K
N
D
Q
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
R
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
R
E
L
L
D
L
L
Y
----