@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL29: (2017-10-31 )
MTSAEIREAFLRYFETQGHTRVASSSLVPANDPTLLFTNAGMNQFKDCFLGLEKRDYVRATTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKRDALKFAWEFLTSEQWLALPKDKLYVTVYHTDDEAYDIWNKEIGLAPERIIRIGDNKGEKYASDNFWAMGDTGPCGPCSEIFFDHGEHIWGGLPGSPEEDGDRFIEIWNNVFMQFNRTADGVLHPLPAPSVDTGMGLERISAVLQHVNSNYDIDLFQHLLKAAANIIGIEDEGQPSLRVVADHARSCCFLIADGVNPSNEGRGYVLRRIIRRAVRHGNKLGATGTFFYKMLQPLIEVMGQAYPELEARREVIEATLIREEEQFAKTLEQGLKLLEGELAQLKDKTIPGATVFKLYDTYGFPTDLTADIARERGFIIDEAGFEVEMAAQRQRAHDAGKFAVDYNNIVKVEGETQFDGYTNTTGQGQIVAIYKDGVQVDEVSEGDEALIVLNQTPFYAESGGQIGDTGIFKNETGIFEVQDTKKSGGAFVHQGIVTVGNLKTSQNVEAIVKADIREATAHNHSATHLLHAALRQILGSHVQQKGSLVTSDILRFDFANDQPVSFEQLQQVERLVNAEIIANTAVTTELLDIETAKAKGAMMLFGEKYGDEVRVLSMGSVIDEKNFSIELCGGIHVKRTGDIGLFKITSEGGVAAGVRRIEAVTGTKALEVVQKADHDIQYINSLLKAQKDQTVERVQANVELVSALQKQIEQLNQKLANFQAADLIDQVQTIAGRQTLITTVQGVDAKALRNLHDSVKSKLENAVIVLAGVEGDKVSLLASVASQYTANLKAGDIIKHLATELGGKGGGKPDLAQGGAPLNEKFGQVMAALPAWLEQK
Atome Classification :
(24 SA)
.........10........20........30........40........50....-----..-----..60........70........80........90........100.......110.......120.......130..--------.--------....140.......150.......160.......170.......180.......190.......--200..-.....210.......220.......230.......240.......250.......260...---------...----.270----------...--....280.......290.......300.......310.......320........330.......340.......350.......360.......370.......380...---....390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
S
A
E
I
R
E
A
F
L
R
Y
F
ETQGHTRVASSSLVPAND
P
T
L
L
F
TNA
G
M
N
Q
F
K
D
C
F
LGLEKR-----
D
Y
-----
V
RAT
T
S
Q
K
C
V
R
AGGKHNDLDNVGY
T
A
R
H
H
T
F
F
E
M
LGNFS
F
G
D
Y
F
K
R
D
A
L
K
F
A
W
E
F
LT
S
E
Q
WLALPKD
K
L
Y
V
T
V
Y
HTD--------D--------
E
A
Y
D
I
W
N
K
EIGL
A
P
E
R
I
I
R
IGDNKGEKYASDN
F
W
AMGDTGPCG
P
C
S
E
I
F
F
DHG
E
H
I
WGGLPGSP--EED
G
D
-
R
F
I
E
I
W
N
N
V
F
M
QFNRTADGVLHPLPAPSVDTGM
G
L
E
R
I
S
A
V
L
Q
H
VNSNY
D
I
D
L
F
Q
H
L
L
K
A
A
---------
A
N
I
----
I
GIE----------DEG--QP
S
L
R
V
V
A
D
HAR
S
C
C
F
L
I
ADGVNPSNEG
R
G
Y
V
L
R
R
I
I
R
R
A
V
RHGN-KLG
A
T
G
T
F
F
Y
K
M
L
Q
P
L
I
E
V
M
G
Q
AY
P
E
L
E
A
R
R
E
V
I
E
A
T
L
I
R
E
E
E
Q
F
A
K
T
L
E
Q
G
L
K
L
L
E
G
E
L
A
Q
L
KD---KTIPG
A
T
V
F
K
L
Y
DTYGFPT
D
L
T
A
D
I
A
R
ERG
F
I
IDEAGF
E
V
E
M
A
A
Q
R
Q
RAHDA
G
K
F
A
V
DYN
N
I
V
K
VEGETQFDGYTNTTGQ
G
Q
I
V
A
I
YKDGVQVDEVSEGD
E
A
L
I
V
L
NQTPFYAESGGQIGDTGIFKNET
G
I
F
E
V
QDTKKSGG
A
F
V
H
Q
G
I
V
T
VGNLKTS
Q
N
V
E
A
I
V
K
A
D
I
R
E
A
TAHN
H
S
A
T
H
L
L
H
A
A
L
R
Q
I
L
G
S
H
V
Q
QKGS
L
V
T
S
D
I
L
R
F
DFANDQPV
S
F
E
Q
L
Q
Q
V
E
R
L
V
N
A
E
I
I
ANT
A
V
T
T
E
L
L
D
IETAKAK
G
A
M
M
L
F
GEKYGD
E
V
R
V
L
S
MGSVIDEKN
F
S
I
E
L
CG
G
I
H
V
K
RTGD
I
G
L
F
K
I
TSEGG
V
A
A
G
V
R
R
I
E
A
VTG
T
K
A
L
E
V
V
Q
KADH
D
I
Q
Y
I
N
S
L
L
K
AQK
D
Q
T
V
E
R
V
Q
A
N
V
E
L
V
S
A
L
Q
K
Q
I
E
Q
L
N
Q
K
L
AN
F
Q
A
A
D
L
I
D
Q
V
Q
T
I
AGR
Q
T
L
I
T
T
VQGV
D
A
K
A
L
R
N
L
H
D
S
V
K
S
K
LEN
A
V
I
V
L
AGVEG
D
K
V
S
L
L
A
S
V
A
S
Q
Y
TANLK
A
G
D
I
I
K
H
L
A
T
ELGGKGGGKPDLAQGGA
P
L
N
E
K
F
G
Q
V
M
A
A
L
P
A
W
LEQK
5
PsiBlast_PDB
92.79
72%
-98
- C2 -
-
3HXY
3
SYA_ECOLI
A:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.63
72%
-97
- C2 -
-
3HXU
5
SYA_ECOLI
A:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
92.56
72%
-96
- C2 -
-
3HY0
4
SYA_ECOLI
B:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
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T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.39
72%
-96
- C2 -
-
3HXZ
6
SYA_ECOLI
A:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.39
72%
-98
- C2 -
-
3HXX
1
SYA_ECOLI
A:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
92.11
72%
-97
- C2 -
-
3HY0
4
SYA_ECOLI
A:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
92.10
72%
-97
- C2 -
-
3HXZ
4
SYA_ECOLI
C:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.09
72%
-96
- C2 -
-
3HXW
5
SYA_ECOLI
A:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
92.03
72%
-96
- C2 -
-
3HXZ
4
SYA_ECOLI
D:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
91.97
72%
-96
- C2 -
-
3HXZ
6
SYA_ECOLI
B:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.75
72%
-95
- C2 -
-
3HXV
6
SYA_ECOLI
A:
[3-441]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
90.87
72%
-93
- C2 -
-
3HY1
2
SYA_ECOLI
A:
[3-440]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.40
72%
-105
- C2 -
-
3HY1
1
SYA_ECOLI
B:
[3-437]
-
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
--------------------
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
----------
D
L
S
--
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
86.92
72%
-57
- C2 -
-
3HXZ
6
SYA_ECOLI
B:
[2-439]
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
-----------
D
L
S-
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
86.83
72%
-55
- C2 -
-
3HY0
4
SYA_ECOLI
A:
[2-439]
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
L
D
K
R
-----
N
Y
-----
S
R
A
T
T
S
Q
R
C
V
R
A
G
G
K
H
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
D
N
K
G
A
P
Y
A
S
D
N
F
W
Q
M
G
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
S
P
--
E
E
D
G
D
-
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
---------
A
K
V
----
T
G
A
T
-----------
D
L
S-
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
70.55
54%
0
- C- -
-
1YFR
1
SYA_AQUAE
B:
[3-434]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
E
K
R
-----
P
Y
-----
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
------------
E
Y
E
G
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
---------
E
E
V
SGKK
Y
G
E
K
----------
F
E
T
--
D
V
A
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
EGR
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
F
Q
C
E
L
E
E
Q
R
E
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
70.55
54%
0
- C- -
-
1YFS
1
SYA_AQUAE
B:
[3-434]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
E
K
R
-----
P
Y
-----
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
------------
E
Y
E
G
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
---------
E
E
V
SGKK
Y
G
E
K
----------
F
E
T
--
D
V
A
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
EGR
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
F
Q
C
E
L
E
E
Q
R
E
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.55
54%
0
- C- -
-
3HTZ
-
SYA_AQUAE
A:
[2-434]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
E
K
R
-----
P
Y
-----
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
------------
E
Y
E
G
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
---------
E
E
V
S
GKK
Y
G
E
K
----------
F
E
T
--
D
V
A
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
GR
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
F
Q
C
E
L
E
E
Q
R
E
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.55
54%
0
- C- -
-
1YGB
1
SYA_AQUAE
A:
[3-434]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
E
K
R
-----
P
Y
-----
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
------------
E
Y
E
G
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
---------
E
E
V
S
GKK
Y
G
E
K
----------
F
E
T
--
D
V
A
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
GR
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
F
Q
C
E
L
E
E
Q
R
E
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.55
54%
0
- C- -
-
1YFT
1
SYA_AQUAE
A:
[3-434]
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
L
E
K
R
-----
P
Y
-----
K
R
A
T
S
C
Q
K
C
L
R
V
S
G
K
H
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E
-------
E
D
N
F
W
Q
M
G
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
------------
E
Y
E
G
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
---------
E
E
V
S
GKK
Y
G
E
K
----------
F
E
T
--
D
V
A
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
GR
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
G
F
Q
C
E
L
E
E
Q
R
E
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
63.80
49%
-10
- C2 -
-
4XEM
6
SYAC_HUMAN
A:
[25-404]
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
T
I
D
P
SHPMA
K
L
-----
S
R
A
A
N
T
Q
K
C
I
R
A
G
----
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
--
Q
E
F
G
I
P
I
E
R
L
Y
V
T
Y
F
G
G
D
EAAGLEAD
L
--------
E
C
K
Q
I
W
Q
N
-
L
G
L
D
D
T
K
I
L
P
G
N
M
-------
K
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
I
G
G
R
D
--
A
A
H
L
V
--
N
Q
D
D
P
-
N
V
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
I
L
K
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
D
L
F
V
P
Y
F
E
A
I
---------
Q
K
G
----
T
G
A
R
PYTGKVGAED
A
D
G
I
-
D
M
A
Y
R
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
R
R
A
V
R
Y
A
H
E
K
L
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.01
47%
22
- C2 -
-
4XEO
3
SYAC_HUMAN
A:
[25-408]
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
T
I
D
P
-----
S
H
PMAKL
S
R
A
A
N
T
Q
K
C
I
R
A
G
G
K
H
N
-
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
E
--
F
G
I
P
I
E
R
L
Y
V
T
Y
F
G
G
D
--------
E
AAGLEAD
L
E
C
K
Q
I
W
-
Q
N
L
G
L
D
D
T
K
I
L
P
-
G
N
M
K
------
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
----
I
G
G
R
D
A
A
H
LV
N
Q
D
D
P
-
N
V
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
I
L
K
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
TGARPY
T
G
K
----
V
G
A
E
----------
D
A
D
G
I
D
M
A
Y
R
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
H
R
A
V
R
Y
A
H
E
K
L
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
T
L
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
59.96
47%
14
- C2 -
-
4XEM
6
SYAC_HUMAN
A:
[25-404]
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
T
I
D
P
-----
S
H
PMAKL
S
R
A
A
N
T
Q
K
C
I
R
A
G
----
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
E
--
F
G
I
P
I
E
R
L
Y
V
T
Y
F
G
G
D
--------
E
AAGLEAD
L
E
C
K
Q
I
W
-
Q
N
L
G
L
D
D
T
K
I
L
P
-
G
N
M
K
------
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
----
I
G
G
R
D
A
A
H
LV
N
Q
D
D
P
-
N
V
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
I
L
K
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
T
GARPY
T
G
K
----
V
G
A
E
----------
D
A
D
G
I
D
M
A
Y
R
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
R
R
A
V
R
Y
A
H
E
K
L
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
59.46
47%
13
- C2 -
-
4XEO
5
SYAC_HUMAN
B:
[25-405]
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
T
I
D
P
-----
S
H
PMAKL
S
R
A
A
N
T
Q
K
C
I
R
A
-----
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
E
--
F
G
I
P
I
E
R
L
Y
V
T
Y
F
G
G
D
--------
E
AAGLEAD
L
E
C
K
Q
I
W
-
Q
N
L
G
L
D
D
T
K
I
L
P
-
G
N
M
K
------
D
N
F
W
E
M
G
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
----
I
G
G
R
D
A
A
H
LV
N
Q
D
D
P
-
N
V
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
I
L
K
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
D
L
F
V
P
Y
F
E
A
I
Q
K
G
TGARPY
T
G
K
----
V
G
A
E
----------
D
A
D
G
I
D
M
A
Y
R
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
H
R
A
V
R
Y
A
H
E
K
L
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------