@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL37: (2017-10-31 )
MQFKPLGHTGINLPEICLGTMTFGEQNTQQEAFEQLNYALEHGLYFWDTAEMYSVPPKPETYGATETILGNWFAQHGQRDKVFLASKIAGPGFGGTHIRDGHTKFNSEHISQAIDGSLKRLKTDYIDLYQLHWPERHTNFFGTLAYGNQQAQNDYDTTPLEETLLALQKEINRGRIRYIGLSNETPWGTMKFLQLAENLGVSKFVSVQNPYSVLNRTYEIGMSEIAKYEGVGLLAYSPLAFGYLTGKFRNGARPANARVTLFPRFSRYSNPQSEWATEQYAQLAEKHGLSLTQLALAFIKQQFFVTSTIIGATNLDQLKENIQAFEIELSPEILQGIEAIHIQQPNPAP
Atome Classification :
(20 SA)
-.........10........20...-.-.....30........40........50........60.--.......70.....--.-..80........90........100.......110.......120.......130.......140.......150.......---160.......170.......180.......190.......200.......210....-.-.-.-220.......230.......240.......250......-----.260-.-...----...---.---270.......280.------......290.......300.......310.......320....-.--..330.......340.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MQFKPLGHTGIN
L
P
E
I
C
L
G
T
-MTF-G-EQN
T
Q
Q
E
A
F
E
Q
L
N
Y
A
L
EHG
L
Y
F
W
D
T
A
E
MYSVPPKPETY--G
A
T
E
T
I
L
G
N
W
F
A
QH--G-QR
D
K
V
F
L
A
SKIAGPGFGGTHIRDGHTKF
N
S
E
H
I
S
Q
A
I
D
G
S
L
K
R
L
K
T
D
Y
I
D
L
Y
QLHWPERHT
N
F
F
G
T
L
AYGNQQAQNDYDTT
P
---
L
E
E
T
L
L
A
L
Q
K
EINRG
R
I
R
Y
I
GLSNETP
W
G
T
M
K
F
L
Q
L
A
E
NLGV
S
K
F
V
SVQ
N
P
Y
S
V
L
N
R
-
T
-
Y
-E-I
G
M
S
E
I
A
K
YEG
V
G
L
L
A
YS
P
L
A
F
G
Y
L
TGKFRNGARPAN
A
R
-----
V
T
-
L
-
F
-PRF----SRY---S---N
P
Q
S
E
W
A
T
E
Q
Y
A
Q
L
------
A
E
KHGL
S
L
T
Q
L
A
L
A
F
I
K
Q
Q
F
F
V
T
S
TIIGAT
N
L
D
Q
L
K
E
NI
Q
A
F
E
-
I
--EL
S
P
E
I
L
QGI
E
A
I
H
IQQPNPAP
34
HHSearch
84.95
49%
-82
- C4 -
-
1LQA
1
TAS_ECOLI
B:
[1-346]
-
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
-
M
T
F
-
G
-
E
Q
N
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
P
P
R
P
E
T
Q
--
G
L
T
E
T
Y
V
G
N
W
L
A
K
H
--
G
-
S
R
E
K
L
I
I
A
S
K
V
S
G
P
S
R
N
N
D
K
G
I
R
P
D
Q
A
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
P
Q
R
P
T
N
C
F
G
K
L
G
Y
S
W
T
D
---
S
A
P
A
V
S
---
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
D
K
H
D
L
P
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
-
S
-
F
-
E
-
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
Y
L
N
G
A
K
P
A
G
A
R
-----
N
T
-
L
-
F
-
S
R
F
----
T
R
Y
---
S
---
G
E
Q
T
Q
K
A
V
A
A
Y
V
D
I
------
A
R
R
H
G
L
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
L
S
E
D
V
L
A
E
I
E
A
V
H
Q
V
Y
T
Y
P
A
P
21
PsiBlast_CBE
80.75
49%
-32
- C4 -
-
1LQA
1
TAS_ECOLI
B:
[1-346]
-
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
-
M
T
F
-
G
-
E
Q
N
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
P
P
R
P
E
T
Q
--
G
L
T
E
T
Y
V
G
N
W
L
A
K
H
--
G
-
S
R
E
K
L
I
I
A
S
K
V
S
G
P
S
R
N
N
D
K
G
I
R
P
D
Q
A
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
P
Q
R
P
T
N
C
F
G
K
L
G
Y
S
W
T
------
D
S
A
P
AVS
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
D
K
H
D
L
P
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
-
S
-
F
-
E
-
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
Y
L
N
G
A
K
P
A
G
A
R
-----
N
T
-
L
-
F
-
S
R
F
----
T
R
Y
---
S
---
G
E
Q
T
Q
K
A
V
A
A
Y
V
D
I
------
A
R
R
H
G
L
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
L
S
E
D
V
L
A
E
I
E
A
V
H
Q
V
Y
T
Y
P
A
P
1
PsiBlast_PDB
80.36
49%
-31
- C4 -
-
1LQA
1
TAS_ECOLI
A:
[1-346]
-
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
-
M
T
F
-
G
-
E
Q
N
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
P
P
R
P
E
T
Q
--
G
L
T
E
T
Y
V
G
N
W
L
A
K
H
--
G
-
S
R
E
K
L
I
I
A
S
K
V
S
G
P
S
R
N
N
D
K
G
I
R
P
D
Q
A
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
P
Q
R
P
T
N
C
F
G
K
L
G
Y
S
W
T
------
D
S
A
P
AVS
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
D
K
H
D
L
P
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
-
S
-
F
-
E
-
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
Y
L
N
G
A
K
P
A
G
A
R
-----
N
T
-
L
-
F
-
S
R
F
----
T
R
Y
---
S
---
G
E
Q
T
Q
K
A
V
A
A
Y
V
D
I
------
A
R
R
H
G
L
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
L
S
E
D
V
L
A
E
I
E
A
V
H
Q
V
Y
T
Y
P
A
P
6
PsiBlast_PDB
68.80
29%
0
- C- -
-
2A79
4
KCAB2_RAT
A:
[5-325]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
37
HHSearch
63.16
29%
-4
- C4 -
-
1EXB
1
KCAB2_RAT
A:
[2-326]
-
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
-
F
G
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
--
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G-
W
-
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-----
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
--------------------
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
-
E
-
K
V
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
P
P
Y
-
S
R
-----
A
S
---
L
-
K
G
Y
Q
W
L
K
D
K
I
---
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
------
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
Y
S
--
4
PsiBlast_PDB
62.42
29%
9
- C4 -
-
3LUT
1
KCAB2_RAT
A:
[39-359]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
---
W
G
G
K
A
--
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
35
HHSearch
62.14
30%
8
- C4 -
-
1QRQ
1
KCAB2_RAT
C:
[2-322]
-
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
--
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G-
W
-
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-----
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
--------------------
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
-
E
-
K
V
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
P
P
-
Y
S
R
-----
A
S
-
L
-
K
G
Y
Q
W
LK--
D
K
I
---
L
SEE
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
------
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
------
7
PsiBlast_PDB
62.11
29%
10
- C4 -
-
2R9R
1
KCAB2_RAT
A:
[5-325]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
24
Fugue
61.61
30%
15
- C4 -
-
1QRQ
1
KCAB2_RAT
A:
[1-325]
L
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
--
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-----
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
--------------------
N
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
-
E
K
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
P
P
Y
S
R
A
SLKGY
Q
W
-
L
-
K
-
D
K
I
----
L
S
E
---
E
---
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
------
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
Y
---
5
PsiBlast_PDB
61.50
29%
9
- C4 -
-
1EXB
1
KCAB2_RAT
A:
[4-324]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
41
HHSearch
61.39
29%
6
* C4 *
-
3EAU
1
KCAB2_RAT
A:
[3-324]
-
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-------
A
--
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G-
W
-
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-----
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
--------------------
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
-
E
-
K
-
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
P
P
Y
-
S
R
-----
A
S
-
L
K
G
-
Y
Q
W
L
K
--
D
K
I
L
S
E
E
---
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
------
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
-----
13
PsiBlast_PDB
61.32
29%
9
- C4 -
-
1QRQ
1
KCAB2_RAT
A:
[4-324]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
11
PsiBlast_PDB
61.30
29%
10
- C4 -
-
4JTD
1
KCAB2_RAT
A:
[5-325]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
51
HHSearch
61.27
28%
20
- C4 -
-
4AUB
1
GPR_ECOLI
G:
[33-357]
-
M
Q
Y
R
Y
C
G
K
S
G
L
R
L
P
A
L
S
L
G
L
-
W
H
N
F
G
-
H
V
N
A
L
E
S
Q
R
A
I
L
R
K
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
G
-------
P
PP
G
S
A
E
E
N
F
G
R
L
L
R
E
D
FA
A
-
Y
R
D
E
L
I
I
S
T
K
A
G
Y
D
M
W
P
----
G
P
Y
G
S
G
G
S
R
K
Y
L
L
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
S
H
R
V
D
E
N
T
--------------------
P
---
M
E
E
T
A
S
A
L
A
H
A
V
Q
S
G
K
A
L
Y
V
G
I
S
S
Y
S
P
E
R
T
Q
K
M
V
E
L
L
R
E
W
K
-
I
P
L
L
I
H
Q
P
S
Y
N
L
L
N
R
-
W
-
V
-
D
K
S
G
L
L
D
T
L
Q
N
N
G
V
G
C
I
A
F
T
P
L
A
Q
G
L
L
T
G
K
Y
L
N
G
I
-
P
Q
D
S
R
-----
M
H
R------
L
T---
P
K
M
---
L
---
T
E
A
---
S
L
R
L
L
N
E
M
------
A
Q
Q
R
G
Q
S
M
A
Q
M
A
L
S
W
L
L
K
D
D
R
V
T
S
V
L
I
G
A
S
R
A
E
Q
L
E
E
N
V
Q
A
L
N
N
L
--
T
F
S
T
K
E
L
A
Q
I
D
Q
H
I
A
D
G
E
L
---
2
PsiBlast_PDB
61.21
29%
10
- C4 -
-
1ZSX
1
KCAB2_HUMAN
A:
[26-346]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
Q
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
T
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
D
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
I
H
E
I
D
S
I
L
G
N
K
P
----
12
PsiBlast_PDB
61.18
29%
8
- C4 -
-
3EAU
1
KCAB2_RAT
A:
[5-325]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
9
PsiBlast_PDB
61.11
29%
12
- C4 -
-
4JTA
1
KCAB2_RAT
A:
[5-325]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
3
PsiBlast_PDB
60.84
29%
11
- C4 -
-
3EB3
1
KCAB2_RAT
A:
[5-325]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
A
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
17
PsiBlast_PDB
60.73
29%
11
- C4 -
-
3EB4
1
KCAB2_RAT
A:
[5-325]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
R
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----
10
PsiBlast_PDB
60.57
29%
11
- C4 -
-
4JTC
1
KCAB2_RAT
A:
[5-325]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
-
G
-
G
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
---------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
--
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
E
T
E
-----
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
----------------
V
F
A
N
R
P
D
P
N
----
T
P
---
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
-
E
-
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
-
P
P
Y
S
R
-----
A
S
-
L
-
K
-
G
Y
Q
----
W
L
K
---
D
---
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
----