@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL69: (2017-10-31 )
MRAYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSKGFPLLTTKKVHFRSIVIELLWFLKGDTNVKYLQDNKVTIWDEWATAEQTARFGRPEHELGPVYGHQWRNFGATKNADGTYNQDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDNKLSCQLYQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDIHLYANHFEQAKLQLMREPLPLCQLKLNPDVKDIFDFKFEDIEIVGYESHPAIKAPVAV
Atome Classification :
(100 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40.........50........60........70........80.......---.---90.-----------------------------------------.-----------------------------------------.---.---....100.......110.-.-.---------------------------....120.......130.......140.......150.......160.......170--........180.......190.......200.......210.......220.......230.......240.......250-----------.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
R
A
Y
L
D
L
L
Q
H
I
L
DNGGDKGDRTGTGTRSVFGH
Q
M
R
F
DLSK-GFPLLTTK
K
V
H
F
R
S
I
V
I
E
L
L
W
F
LKGDTN
V
K
Y
L
QDN
K
V
T
I
W
DEWA
T
A
E
Q
---
T
---
A
RF-----------------------------------------G-----------------------------------------R---P---EHELGPVYGHQWRNFGAT-K-N---------------------------ADGTYNQ
D
G
F
D
Q
I
K
W
L
I
N
E
I
KTNPNS
R
R
L
I
V
SGWNPNEAG
Q
V
ALP
P
C
H
T
L
F
Q
F
F
V-Q--DNK
L
S
C
Q
L
Y
QRSA
D
V
F
L
GV
P
F
N
I
A
S
Y
A
L
L
T
H
M
I
A
Q
V
CGLGV
G
D
F
V
WTGG
D
I
H
L
Y
A
N
H
F
E
Q
A
K
L
Q
L
M
REPL
P
L
C
Q
L
K
LNP
D
V
-----------
K
D
I
F
DFKFE
D
I
E
I
V
GYESHPAIKAPVAV
11
PsiBlast_PDB
93.33
60%
-145
- C6 -
-
1AXW
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
10
PsiBlast_PDB
93.26
60%
-144
- C6 -
-
1AN5
1
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
9
PsiBlast_PDB
93.20
60%
-141
- C6 -
-
1TDU
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
128
HHSearch
93.11
61%
-147
* C6 *
-
4FOX
3
TYSY_MYCTU
D:
[1-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
Q
Q
M
R
Y
D
L
S
A
-
G
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
S
D
-------------------------------------------------------------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
A
------------------------------------
P
S
G
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
L
A
D
R
------------
D
S
I
F
E
Y
T
Y
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
7
PsiBlast_PDB
93.02
60%
-146
- C6 -
-
1TSD
5
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
3
PsiBlast_PDB
93.02
60%
-147
- C6 -
-
2KCE
3
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
15
PsiBlast_PDB
92.96
60%
-148
- C6 -
-
1TRG
2
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
6
PsiBlast_PDB
92.90
60%
-145
- C6 -
-
1TLC
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
30
PsiBlast_CBE
92.86
60%
-143
- C6 -
-
2TSC
3
TYSY_ECOLI
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
A
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
1
PsiBlast_PDB
92.72
63%
-185
- C6 -
-
3IX6
-
TYSY_BRUME
A:
[1-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
T
Y
L
D
L
L
Q
H
V
L
D
H
G
V
D
R
D
D
----
G
T
R
S
V
F
G
Y
Q
M
R
F
D
L
E
E
-
G
F
P
V
L
---
K
L
H
L
R
S
I
I
H
E
L
L
W
F
L
K
G
D
T
N
I
A
Y
L
K
E
N
G
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
Y
Q
W
R
S
W
P
A
--------------------------------
P
D
G
R
H
----
I
D
Q
I
A
N
L
L
K
M
L
H
T
N
P
Q
S
R
R
L
I
V
S
A
W
N
P
A
L
V
D
E
M
A
L
P
P
C
H
C
L
F
Q
F
Y
V
-
A
--
N
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
I
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
M
M
I
A
Q
V
T
G
L
K
P
G
E
F
I
H
T
L
G
D
A
H
I
Y
S
N
H
F
E
Q
A
R
L
Q
L
T
R
T
P
K
K
L
P
V
M
H
I
N
P
D
V
-----------
K
D
L
F
A
F
R
F
E
D
F
R
L
D
G
-------------
129
HHSearch
92.61
61%
-145
- C6 -
-
4FQS
3
TYSY_MYCTU
A:
[1-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
Q
Q
M
R
Y
D
L
S
A
-
G
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
S
D
-------------------------------------------------------------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
A
------------------------------------
P
S
G
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
L
A
D
R
------------
D
S
I
F
E
Y
T
Y
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
118
HHSearch
92.23
63%
-145
- C6 -
-
1TJS
-
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
-------------------------------------------------------------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
T
------------------------------------
P
D
G
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
17
PsiBlast_PDB
92.23
60%
-143
- C6 -
-
2TSC
3
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
A
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
2
PsiBlast_PDB
92.19
60%
-141
- C6 -
-
2BBQ
3
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
104
Fugue
92.15
52%
0
- C- -
-
1QZF
5
?
A:
[3-521]
E
K
N
V
S
I
V
V
A
A
S
VLSSGIGINGQLPWSI
S
E
D
L
K
F
F
S
K
I
T
N
NKCDSN
K
K
N
A
L
I
M
G
R
K
T
W
D
S
I
GRRPLKN
R
I
I
V
V
I
S
SSLPQDEADPN
V
V
V
F
RNLEDSIENLMNDDSIENIFVCGG
E
S
I
Y
R
D
A
L
K
D
NFVDRIY
L
T
R
V
ALEDIEFD
T
Y
F
P
EIPETFLPV
Y
M
S
Q
T
FCTKN
I
S
Y
D
F
M
I
F
E
KQEKKTLQNCDPARGQL
K
S
I
D
D
T
V
D
L
L
G
E
I
F
GIRK
M
G
N
R
H
KFPKEEIYNTPSIRFGREHY
E
F
Q
Y
L
D
L
L
S
R
V
L
E
N
G
A
Y
R
E
N
R
T
G
I
S
T
Y
S
I
F
G
Q
M
M
R
F
D
M
R
E
-
S
F
P
L
L
T
T
K
K
V
A
I
R
S
I
F
E
E
L
I
W
F
I
K
G
D
T
N
G
N
H
L
I
E
K
K
V
Y
I
W
S
G
N
G
S
K
E
Y
---
L
---
E
R
I
-----------------------------------------
G
LGH--------------------------------------
R
---
E
---
E
N
D
L
G
P
I
Y
G
F
Q
W
R
H
Y
N
G
E
Y
K
-
T
---------------------------
M
H
D
D
Y
T
G
V
G
V
D
Q
L
A
K
L
I
E
T
L
K
N
N
P
K
D
R
R
H
I
L
T
A
W
N
P
S
A
L
S
Q
M
A
L
P
P
C
H
V
L
S
Q
Y
Y
V
T
N
--
D
N
C
L
S
C
N
L
Y
Q
R
S
C
D
L
G
L
G
S
P
F
N
I
A
S
Y
A
I
L
T
M
M
L
A
Q
V
C
G
Y
E
P
G
E
L
A
I
F
I
G
D
A
H
I
Y
E
N
H
L
T
Q
L
K
E
Q
L
S
R
T
P
R
P
F
P
Q
L
K
F
K
R
K
V
-----------
E
N
I
E
D
F
K
W
E
D
I
E
L
I
G
Y
Y
P
Y
P
T
I
K
M
D
M
A
V
8
PsiBlast_PDB
92.10
60%
-140
- C6 -
-
1DDU
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
12
PsiBlast_PDB
91.94
60%
-144
- C6 -
-
1BDU
1
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
19
PsiBlast_PDB
91.91
59%
-143
- C6 -
-
3B5B
3
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
Q
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
5
PsiBlast_PDB
91.84
60%
-145
- C6 -
-
1AOB
1
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
4
PsiBlast_PDB
91.84
60%
-142
- C6 -
-
3TMS
-
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
27
PsiBlast_CBE
91.75
60%
-144
- C6 -
-
1DDU
2
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
16
PsiBlast_PDB
91.71
60%
-143
- C6 -
-
1SYN
3
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
29
PsiBlast_CBE
91.53
60%
-146
- C6 -
-
1AN5
1
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
22
PsiBlast_CBE
91.47
60%
-144
- C6 -
-
2BBQ
3
TYSY_ECOLI
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
31
PsiBlast_CBE
91.41
59%
-141
- C6 -
-
3B5B
3
TYSY_ECOLI
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
Q
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
24
PsiBlast_CBE
91.37
60%
-143
- C6 -
-
1TLC
3
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
28
PsiBlast_CBE
91.35
60%
-143
- C6 -
-
1AXW
3
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
13
PsiBlast_PDB
91.34
60%
-147
- C6 -
-
1BID
1
TYSY_ECOLI
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
21
PsiBlast_CBE
90.89
60%
-143
- C6 -
-
2KCE
3
TYSY_ECOLI
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
26
PsiBlast_CBE
90.81
60%
-143
- C6 -
-
1SYN
3
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
18
PsiBlast_PDB
90.76
59%
-144
- C6 -
-
2VET
2
TYSY_ECOLI
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
Q
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
23
PsiBlast_CBE
90.59
60%
-146
- C6 -
-
1TSD
3
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
25
PsiBlast_CBE
90.46
60%
-144
- C6 -
-
1TDU
2
TYSY_ECOLI
B:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
H
Q
M
R
F
N
L
Q
D
-
G
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
D
E
N
G
-------------------------------------------------------------------------------------------------------
D
L
G
P
V
Y
G
K
Q
W
R
---
A
W
-
P
-
T
---------------------------
P
D
G
R
H
----
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
Y
V
-
A
--
D
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
I
K
R
K
P
-----------
E
S
I
F
D
Y
R
F
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
125
HHSearch
85.30
60%
-38
- C6 -
-
3UWL
5
TYSY_ENTFA
B:
[2-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
Y
L
A
L
G
K
K
I
L
E
E
G
H
F
K
E
D
R
T
G
T
G
T
Y
S
L
F
G
Y
Q
M
R
F
D
L
A
K
-
G
F
P
L
L
T
T
K
R
V
P
F
G
L
I
K
S
E
L
L
W
F
L
K
G
D
T
N
I
R
Y
L
L
E
R
N
N
H
I
W
D
E
W
A
F
E
R
Y
---
V
---
K
S
A
-----------------------------------------
D
YQGPDMTD
F
G
H
R
V
L
Q
D
P
A
F
A
E
Q
Y
K
E
E
H
Q
K
F
C
D
A
I
L
ND
A
E
F
A
E
---
K
---
Y
G
E
L
G
N
I
Y
G
A
Q
W
R
H
W
E
T
K
------------------------------------
D
G
S
F
I
D
Q
L
A
N
V
I
E
M
I
K
T
N
P
D
S
R
R
L
I
V
S
A
W
N
P
E
D
V
P
S
M
A
L
P
P
C
H
T
M
F
Q
F
Y
V
-
N
--
E
G
K
L
S
C
Q
L
Y
Q
R
S
A
D
V
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
L
I
A
H
E
T
G
L
E
V
G
E
F
V
H
T
L
G
D
A
H
L
Y
Q
N
H
V
E
Q
M
Q
E
Q
L
S
R
E
V
R
S
F
P
T
L
V
L
N
P
D
K
-----------
A
S
V
F
D
F
D
M
E
D
I
K
V
E
G
Y
D
P
H
P
T
I
K
A
P
I
A
V