@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL86: (2017-11-01 )
MLFFVFSERRSISWHESVKLSLGVLAICVMSLAKLINELNAQQKKAATTMAQNCLVLAGAGCGKTKTIVARAAYLVDQGLPANQIQILTFTRRAASEIVARVEQHVGAQAKGLRASTFHTFCMYLLRRNPQAFGLTQFSIIDRDDQLLMFRLLRGKDKDNVLPKAAELCDLYSYARNTQSKLSEALLKQLPEAYEYKSQIAELMKTYEQRKRERNFLDYDDILSIVDVHLQNSEVLTNWVAGFCQALLVDEMQDTNPLQWALLQPLIGKVKLFCVGDDAQSIYGFRGADFENIHSFKERIPDAVIHTLDLNYRSTQEILDLSNWLLAHSPIDYQKQLQAHRGKGQKPQLHLFGNEFEEANWIAQDLIERHQQGANWYDHMVLVRSGYSARYLEGAFIAAEIPYRFIGGVKLLESAHVKDVLSLLRIVSNPQDDLAWMRFLTLWDGIGDVGASKLAQELMSICEVEERCQRLERHGKVPLQAILILKQLDVLQQHVEASIGLALDALSEQLEQNYKTKDWSRRVRDFDLVKQLARKHASLGEFLEEYVLEPISISEIEKAGDDDLVTLITIHSAKGAEQKVCYVPHVSPNQYPYARAQGDFDEVEEERRVLYVALTRAENELILTKQNLNTWSQDTYDEQGRKIESYFLNDLPAHLVQAKIHRQVPQPFAKKQWNTSRTVNLGFGIDLD
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------.........10........20........30........-40........-50........60.......-.70.....-.-.---.---------80........90........100.....-.-------------------------------------.110.......120.......130...-..-..140....--.-..150...-------.--...--160------------------------------------.----------.-.--......170---------------------------.--------------.----.----.-----------....-----------------------------180-----------------------..--.....-----------------------------.----.--190---------------------...-----.....200..-------.....210.......220.----.-......230.------.--------......240....----...250.......260.....----.---.270----...-.....280.......290.......300---.-----......-----..310.......320......------.330...-----.-----...340-.------.--------------.------..-------...--------350--.-....----..360....-----------...370------------.---------------.....-..----------380.......390.......400.....-..410.......420.......430.......440...-....-----.450..----.-------....460........470-----....----.-..--.480-...------------.....-.----490-.--..-------.....--.500.--.--..-...-..510...-....----------520...----....530...---------.-------------------------.-------.-----.540......----.550.----.----..------------.------..560--.......570.......580.....-----..-----------------------------590-----.-----.....-----------------------------------.600.......610.......620..------.....630........640.......650....-...660.......670.......680......----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------
M
L
F
F
V
FSERRSISW
H
E
S
V
K
L
S
L
G
V
L
A
I
C
V
M
S
L
A
K
L
I
N
E
L
-
N
A
Q
Q
K
K
A
A
T
T
-
M
AQ
N
C
L
V
L
AGAGCGK
T
K
T
I
-
V
A
R
A
A
Y
L
V
-D-Q---G---------LPAN
Q
I
Q
I
L
T
F
T
R
R
A
A
S
E
I
V
A
R
V
E
Q
H
VG-A-------------------------------------QAKGL
R
A
S
T
F
H
T
F
C
M
Y
L
L
RRNPQAFG
L
-
T
Q
-
F
S
I
IDRD
D
Q
--
L
-
L
M
F
R
L
LRG-------K--DKD--N--------------------------------------V----------
L
-
P
--
K
A
A
E
L
C
D
L
----------------------------
Y
--------------
S
----
Y
----
A
-----------
R
N
T
Q
-----------------------------
S
-------------------------
K
L
--
S
E
A
L
L
-----------------------------
K
----Q--L
P
----------------------
E
A
Y
-----
E
Y
K
S
Q
I
A
E
L
M
-------
K
T
Y
E
Q
R
K
R
ERNFL
D
Y
D
D
-
I
----
L
-
S
I
V
D
V
HLQ-
N
------
S
--------
E
V
L
T
N
W
V
A
G
F
C
Q
A
----
L
L
V
D
EMQDTN
P
L
Q
W
A
L
L
Q
P
L
I----G---
K
V
-
K
----
L
F
C
-VGDDA
Q
S
I
YGFRGA
D
F
E
N
I
H
S
F
K
E
RI-----
P
-----
D
A
V
I
H
T
-----LDLNYR
S
T
Q
E
I
L
D
L
S
N
W
L
LAH------SPI
D
Y
Q
K
-----
Q
-----
L
Q
A
H-R-G------K--------------G------QK-------
P
Q
L
--------
H
L
F--G-NEF
E
----
E
A
N
W
I
A
Q
D
L
-----------
I
E
R
H
Q
-------------Q---------------GANWY-
D
H
----------
M
V
L
V
RSGYS
A
R
Y
LE
G
A
F
I
A
A
E
I
P
Y
R
F
I
G
-
G
V
K
L
L
E
S
A
H
V
K
D
V
L
S
L
L
R
I
VSNP
Q
D
D
L
A
W
M
R
F
L
-
T
L
W
D-GIGD-----V
G
A
S
K
L
----
A
-------
Q
E
L
M
S
-
I
C
E
V
E
E
R
C
Q
R
L
------
E
R
HG----K-V
P
--
L
Q
---
A
I
L
------------
I
L
K
Q
L
-
D
----
V
---
L
--
Q
Q
-------
H
V
E
A
S
--
I
G
--
L
--
A
--
L
D
-
A
L
S
-
E
Q
L
E
Q
NYK-T
K
D
W
----------
S
R
RVR
D
----
F
D
L
V
K
Q
L
A
R
K
---------
H
-------------------------
A
-------
S
-----
L
G
E
F
L
E
E
Y
VL----EPI
S
I
----
S
----
E
I
------------
E
------KAGDD--
D
L
V
T
L
I
T
I
HSAKGAEQ
K
V
C
YVPHVS-----PN-----------------------------QYP-----Y-----ARAQG-----------------------------------
D
F
D
E
V
E
E
ER
R
V
L
Y
V
A
L
TRAE
N
E
L
I
L
T
------KQNLNT-WSQDT
Y
D
E
QGR
K
I
E
S
Y
F
LNDL
P
A
H
L
V
-
Q
A
K
I
H
R
QVPQ
P
F
A
K
KQWNTS
R
T
V
N
LGFGIDLD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
81.63
24%
0
- C- -
-
3U4Q
-
ADDA_BACSU
A:
[10-938]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
-
T
D
D
Q
W
N
A
I
V
S
-
T
G
Q
D
I
L
V
A
A
A
A
G
S
G
K
T
A
V
L
-
V
E
R
M
I
R
K
I
-
T
-
A
EE
N
P
---------
I
D
V
D
R
L
L
V
V
T
F
T
N
A
S
A
A
E
M
K
H
R
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L
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-
K
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L
V
Q
R
PGS
L
H
I
R
R
Q
L
S
---------------------
L
L
N
R
A
S
I
S
T
L
H
S
F
C
L
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V
L
K
K
Y
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V
L
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-------
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--
L
F
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A
K
GE
K
A
F
F
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L
V
D
R
YTTDRHD
L
D
L
Q
F
L
V
K
Q
V
Y
E
Y
S
R
S
H
P
----------
N
-
P
E
A
W
L
E
S
F
V
H
L
----------------------------
Y
DVSEKSAIEELPFY
Q
----
Y
V
K
E
D
I
A
M
V
L
N
G
A
----
K
E
K
L
L
R
A
L
E
L
TD
N
F
L
D
D
L
A
Q
I
D
E
----------
L
I
Q
H
Q
DD
F
S
E
L
Y
K
R
VPAVS--------------
D
P
A
L
L
D
E
A
T
D
L
R
N
------------------
G
A
K
K
L
L
--
E
K
L
K
T
D
YFTRS
P
E
Q
H
L
K
S
L
A
E
M
K
P
V
I
E
-----
T
L
V
Q
L
V
I
S
Y
G
-------
K
R
F
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A
A
K
Q
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K
S
I
I
D
F
S
D
-
L
----
E
-
H
Y
C
L
A
I
L
T
-
A
------
E
NDREP---
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
----
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S---
G
PEE
T
G
-
N
----
L
F
M
-
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
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P
L
L
F
L
S
K
Y
K
R
F
-----
T
ESGEG
T
G
R
K
I
D
-----
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
------
L
M
G
G
K
I
G
E
V
D
Y
D
E
QAELK
L
G
A
A
Y
P
D
N
------
D
--------------
E
------
T
E
T
E
L
L
L
I
D-------------
L
--
E
-
T
V
Q
F
----
E
A
K
A
I
A
K
E
I
-----------
R
K
L
I
S
S
PFKVYK
K
T
H
---
R
---------------
N
I
Q
Y
R
-
D
I
----------
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
S
V
L
-
R
S
P
I
V
G
A
D
E
-----
N
E
L
S
L
I
----
R
-------
L
E
N
-
K
-
K
A
P
Y
Y
E
A
M
K
D
Y
------
L
A
A
G
DRSD
E
-
L
Y
Q
K
L
N
T
F
-
Y
G
H
------------
L
Q
K
W
R
-
A
----
F
S
--
K
--
N
H
-------
S
V
S
E
L
--
I
W
E
V
Y
--
R
--
D
T
-
K
Y
M
-
D
Y
V
G
G
M
----
P
G
G
----------
K
Q
R
Q
A
N
----
L
R
V
L
Y
D
R
A
R
Q
Y
E
S
TA----
F
-------------------------
R
-------
G
-----
L
F
R
F
L
R
F
I
E
R
----
M
Q
E
R
G
D--------------------------------
Q
E
--
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
G
-----
R
N
------------------------------
F
N
-----
M
-----
M
D
L
N
K
S
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
T
L
P
L
I
A
M
K
K
K
M
R
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
I
------
G
S
C
K
D
H
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.74
29%
10
- C2 -
-
2IS6
5
UVRD_ECOLI
A:
[1-656]
-----------------------------------------------------------------------------------------------------------------------------------------------------
M
D
V
S
Y
L
L
D
S
L
-
N
D
K
Q
R
E
A
V
A
A
-
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
-
V
H
R
I
A
W
L
M
-
S
V
E
---
N
---------
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
-
T
-------------------------------------
S
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
-
P
Q
D
F
Q
I
L
D
S
E
D
Q
--
L
R
L
L
K
R
L
I
K
A
-------
M
NL
D
E
K
--
Q
--------------------------------------
W
----------
P
-
P
--
R
Q
A
------------------------------------------------
M
----
W
----
Y
-----------
I
N
S
Q
-----------------------------
K
-----------------------------
D
E
G
L
R
-----------------------------
P
----
H
--
H
I
----------------------
Q
S
Y
GN---
P
V
E
Q
T
W
Q
K
V
Y
-------
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
-
L
----
L
L
R
A
H
E
L
W
L
N
-
K
------
P
--------
H
I
L
Q
H
Y
R
E
R
F
T
N
-----
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
----
G
---
D
T
G
K
----
V
M
I
-
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
-----
P
-----
G
A
E
T
I
R
-----
L
E
Q
N
Y
R
S
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S
N
I
L
S
A
A
N
A
L
I
E
N
------
N
N
G
R
L
G
K
-----
K
-----
L
W
T
D
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G
-
A
------
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--------------
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Y
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A
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N
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L
D
----
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A
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V
N
R
I
-----------
K
T
W
Q
D
-------------
N
---------------
G
G
A
L
A
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E
C
----------
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
-
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
-
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
----
D
-------
R
Q
L
T
L
-
W
Q
A
C
R
E
L
L
Q
E
K
------
A
L
A
G
----
R
-
A
A
--
S
A
---
L
Q
R
------------
F
M
E
L
I
-
D
----
A
---
L
--
A
Q
E
T
A
DMP
L
H
V
Q
T
D
--
R
V
--
I
--
K
--
D
S
-
G
L
R
-
T
M
Y
E
Q
E
-
K
-
G
E
K
G
----------
Q
T
R
I
E
N
----
L
E
E
L
V
T
A
T
R
Q
---------
F
-------------------------
S
Y
N
EEDLM
P
-----
L
Q
A
F
L
S
H
A
A
L
----
E
A
-------
G
----
E
G
------------
Q
------
A
D
T
W
Q
--
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
-----
E
G
-----------------------------
M
F
P
-----
S
-----
Q
M
S
L
D
-----------------------------------
E
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
-----
A
E
T
R
R
L
-
Y
G
K
E
V
Y
H
R
P
S
R
-----
F
I
G
E
L
P
E
E
C
V
E
E
V
R
L
R
A
T
V
S
R
P
V
S
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.40
29%
8
- C2 -
-
2IS1
4
UVRD_ECOLI
A:
[2-653]
------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
S
Y
L
L
D
S
L
-
N
D
K
Q
R
E
A
V
A
A
-
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
-
V
H
R
I
A
W
L
M
-
S
V
E
---
N
---------
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
-
T
-------------------------------------
S
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
-
P
Q
D
F
Q
I
L
D
S
E
D
Q
--
L
R
L
L
K
R
L
I
K
A
-------
M
NL
D
E
K
--
Q
--------------------------------------
W
----------
P
-
P
--
R
Q
A
------------------------------------------------
M
----
W
----
Y
-----------
I
N
S
Q
-----------------------------
K
-----------------------------
D
E
G
L
R
-----------------------------
P
----
H
--
H
I
----------------------
Q
S
Y
GN---
P
V
E
Q
T
W
Q
K
V
Y
-------
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
-
L
----
L
L
R
A
H
E
L
W
L
N
-
K
------
P
--------
H
I
L
Q
H
Y
R
E
R
F
T
N
-----
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
----
G
---
D
T
G
K
----
V
M
I
-
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
-----
P
-----
G
A
E
T
I
R
-----
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
------
N
N
G
R
L
G
K
-----
K
-----
L
W
T
D
-
G
-
A
------
D
--------------
G
------
E
P
-------
I
S
L
--------
Y
C
A
--
F
-
N
E
L
D
----
E
A
R
F
V
V
N
R
I
-----------
K
T
W
Q
D
-------------
N
---------------
G
G
A
L
A
-
E
C
----------
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
-
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
-
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
----
D
-------
R
Q
L
T
L
-
W
Q
A
C
R
E
L
L
Q
E
K
------
A
L
A
G
----
R
-
A
A
--
S
A
---
L
Q
R
------------
F
M
E
L
I
-
D
----
A
---
L
--
A
Q
E
TADMP
L
H
V
Q
T
D
--
R
V
--
I
--
K
--
D
S
-
G
L
R
-
T
M
Y
E
Q
E
-
K
-
G
E
K
G
----------
Q
T
R
I
E
N
----
L
E
E
L
V
T
A
T
R
Q
---------
F
-------------------------
S
YNEDLM-
P
-----
L
Q
A
F
L
S
H
A
A
L
----
E
A
-------
G
----
E
G
------------
Q
------
A
D
T
W
Q
--
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
-----
E
G
-----------------------------
M
F
P
-----
S
-----
Q
M
S
L
D
-----------------------------------
E
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
-----
A
E
T
R
R
L
-
Y
G
K
E
V
Y
H
R
P
S
R
-----
F
I
G
E
L
P
E
E
C
V
E
E
V
R
L
R
A
T
V
S
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.62
29%
14
- C2 -
-
2IS2
2
UVRD_ECOLI
A:
[2-646]
------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
S
Y
L
L
D
S
L
-
N
D
K
Q
R
E
A
V
A
A
-
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
-
V
H
R
I
A
W
L
M
-
S
V
E
---
N
---------
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
-
T
-------------------------------------
S
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
-
P
Q
D
F
Q
I
L
D
S
E
D
Q
--
L
R
L
L
K
R
L
I
K
A
-------
M
NL
D
E
K
--
Q
--------------------------------------
W
----------
P
-
P
--
R
Q
A
------------------------------------------------
M
----
W
----
Y
-----------
I
N
S
Q
-----------------------------
K
-----------------------------
D
E
G
L
R
-----------------------------
P
----
H
--
H
I
----------------------
Q
S
Y
GN---
P
V
E
Q
T
W
Q
K
V
Y
-------
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
-
L
----
L
L
R
A
H
E
L
W
L
N
-
K
------
P
--------
H
I
L
Q
H
Y
R
E
R
F
T
N
-----
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
----
G
---
D
T
G
K
----
V
M
I
-
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
-----
P
-----
G
A
E
T
I
R
-----
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
------
N
N
G
R
L
G
K
-----
K
-----
L
W
T
D
-
G
-
A
------
D
--------------
G
------
E
P
-------
I
S
L
--------
Y
C
A
--
F
-
N
E
L
D
----
E
A
R
F
V
V
N
R
I
-----------
K
T
W
Q
D
-------------
N
---------------
G
G
A
L
A
-
E
C
----------
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
-
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
-
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
----
D
-------
R
Q
L
T
L
-
W
Q
A
C
R
E
L
L
Q
E
K
------
A
L
A
G
----
R
-
A
A
--
S
A
---
L
Q
R
------------
F
M
E
L
I
-
D
----
A
---
L
--
A
Q
E
T
A
DMP
L
H
V
Q
T
D
--
R
V
--
I
--
K
--
D
S
-
G
L
R
-
T
M
Y
E
Q
E
-
K
-
G
E
K
G
----------
Q
T
R
I
E
N
----
L
E
E
L
V
T
A
T
R
Q
---------
F
-------------------------
S
YDEDLM-
P
-----
L
Q
A
F
L
S
H
A
A
L
----
E
A
-------
G
----
E
G
------------
Q
------
A
D
T
W
Q
--
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
-----
E
G
-----------------------------
M
F
P
-----
S
-----
Q
M
S
L
D
-----------------------------------
E
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
-----
A
E
T
R
R
L
-
Y
G
K
E
V
Y
H
R
P
S
R
-----
F
I
G
E
L
P
E
E
C
V
E
E
V
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.99
32%
13
- C2 -
-
1PJR
-
PCRA_GEOSE
A:
[7-651]
---------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
L
A
H
L
-
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
-
T
H
R
I
A
Y
L
M
A
E
-
K
---
H
---------
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
-
G
-------------------------------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
-
N
R
N
F
S
I
L
D
P
T
D
Q
--
L
S
V
M
K
T
I
L
K
E
-------
K
-------
N
--------------------------------------
I
----------
D
-
P
--
K
K
F
E
P
R
T
I
----------------------------
L
--------------
G
----
T
----
I
-----------
S
A
A
K
-----------------------------
N
-------------------------
E
L
LP
P
E
Q
F
A
-----------------------------
K
----
R
---------------------------
Y
Y
-----
E
--
K
V
V
S
D
V
Y
-------
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
----
M
-
T
T
I
Q
L
F
D
R
-
V
------
P
--------
D
V
L
H
Y
Y
Q
Y
K
F
-
Q
Y
----
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
----
E
---
R
F
-
Q
----
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
-----
P
-----
N
A
K
V
I
L
-----
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
------
N
V
N
R
K
P
K
-----
R
-----
I
W
T
E
-
N
-
P
------
E
--------------
G
-------
K
-------
P
I
L
--------
Y
Y
E
--
A
M
N
E
A
D
----
E
A
Q
F
V
A
G
R
I
-----------
R
E
A
V
E
-------------
R
---------------
G
E
R
R
Y
R
D
F
----------
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
-
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
-
N
V
P
K
R
G
I
G
A
-----
S
T
I
D
--------------------
L
F
E
A
L
G
E
L
E
M
I
------
G
L
G
A
----
K
-
A
A
--
G
A
---
L
A
A
------------
F
R
S
Q
L
-
E
----
Q
W
T
Q
L
--
Q
E
-------
Y
V
S
V
T
E
L
V
E
--
E
--
V
--
L
D
-
K
S
G
Y
R
E
M
L
K
A
E
R
-
T
I
E
A
----------
Q
S
R
L
E
N
----
L
D
E
F
L
S
V
T
-
K
---------
H
F
E
N
V
SDD------------------
K
-------
S
-----
L
I
A
F
L
T
D
L
A
L
--------
I
----
S
-----------------------------
G
--
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
-----
E
G
-----------------------------
I
F
P
-----
H
-----
N
R
S
L
E
-----------------------------------
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
------
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
-----
F
L
N
E
I
P
A
H
L
L
-
E
T
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
76.89
27%
16
- C2 -
-
4C2U
2
?
A:
[9-648]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
A
L
-
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
-
I
Y
R
I
A
H
L
I
-
G
-
H
Y--
G
---------
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
-
G
H
L
V
-
P
-------------------------------------
G
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
-
R
R
G
F
V
I
Y
D
D
D
D
Q
--
L
-
D
I
I
K
E
V
M
G
SIPG---
E
--
T
Q
P
--
R
--------------------------------------
V
----------
I
-
R
--
G
I
I
D
R
A
K
S
----------------------------
N
--------------
L
----
W
----
T
-----------
P
D
D
L
-----------------------------
D
-------------------------
R
S
--
R
E
P
F
I
-----------------------------
S
----
G
--
L
P
--------------------------------
R
D
A
A
A
E
A
Y
-------
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
-
L
----
I
-
T
E
T
V
R
L
F
K
-
E
------
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
----
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
----
S
---
R
D
-
R
N---
L
L
V
-
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
-----
P
-----
D
A
K
V
Y
M
-----
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
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N
------
N
T
E
R
L
D
K
-----
T
-----
L
K
P
V
-
K
-
E
------
A
--------------
G
------
Q
P
-------
V
T
F
--------
H
R
A
--
T
-
D
H
R
A
----
E
G
D
Y
V
A
D
W
L
-----------
T
R
L
H
G
-------------
E
---------------
G
R
A
W
S
-
E
M
----------
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
-
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
-
G
R
----
P
R
R
-----
G
I
G
D
T
A
----
L
-------
Q
K
L
M
E
-
W
A
R
T
---------------
H
H
----
T
-
S
V
--
L
T
---
A
C
A
------------
N
A
A
E
Q
-
N
----
I
---
L
--
D
R
-------
G
A
H
K
A
--
T
E
--
F
--
A
G
L
M
E
-
A
M
S
-
E
A
A
D
-
N
Y
E
-
P
A
A
F
----------
L
R
F
V
M
E
TSG
Y
L
D
L
L
R
Q
E
G
Q
E
---------
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
DEANVG
G
-------
S
-----
I
A
D
F
L
D
D
A
A
L
LSSV
D
D
M
R
T
----
K
----
A
E
------------
N
------
K
G
A
P
E
--
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
-----
Q
G
-----------------------------
L
L
P
-----
S
K
G
---
A
I
A
E
G
-----------------------------------
P
-
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
-----
A
Q
N
R
M
Q
-
F
G
K
T
N
A
A
E
-----
D
S
A
F
L
E
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.85
27%
20
- C2 -
-
4C2T
1
?
A:
[9-662]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
A
L
-
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
-
I
Y
R
I
A
H
L
I
-
G
-
H
Y--
G
---------
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
-
G
H
L
V
-
P
-------------------------------------
G
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
-
R
R
G
F
V
I
Y
D
D
D
D
Q
--
L
-
D
I
I
K
E
V
M
G
SIPGIGA
E
--
T
Q
P
--
R
--------------------------------------
V
----------
I
-
R
--
G
I
I
D
R
A
K
S
----------------------------
N
--------------
L
----
W
----
T
-----------
P
D
D
L
-----------------------------
D
-------------------------
R
S
--
R
E
P
F
I
-----------------------------
S
----
G
--
L
P
--------------------------------
R
D
A
A
A
E
A
Y
-------
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
-
L
----
I
-
T
E
T
V
R
L
F
K
-
E
------
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
----
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
----
S
---
R
D
-
R
N---
L
L
V
-
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
-----
P
-----
D
A
K
V
Y
M
-----
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
------
N
T
E
R
L
D
K
-----
T
-----
L
K
P
V
-
K
-
E
------
A
--------------
G
------
Q
P
-------
V
T
F
--------
H
R
A
--
T
-
D
H
R
A
----
E
G
D
Y
V
A
D
W
L
-----------
T
R
L
H
G
-------------
E
---------------
G
R
A
W
S
-
E
M
----------
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
-
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
-
G
R
----
P
R
R
-----
G
I
G
D
T
A
----
L
-------
Q
K
L
M
E
-
W
A
R
T
---------------
H
H
----
T
-
S
V
--
L
T
---
A
C
A
------------
N
A
A
E
Q
-
N
----
I
---
L
--
D
R
-------
G
A
H
K
A
--
T
E
--
F
--
A
G
L
M
E
-
A
M
S
-
E
A
A
D
-
N
Y
E
-
P
A
A
F
----------
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
G
Q
E
---------
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
DEANVG
G
-------
S
-----
I
A
D
F
L
D
D
A
A
L
LSS--
D
M
R
T
----
K
----
A
------------------------
E
--
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
-----
Q
G
-----------------------------
L
L
P
-----
S
K
G
---
A
I
A
E
G
-----------------------------------
P
-
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
-----
A
Q
N
R
M
Q
-
F
G
K
T
N
A
A
E
-----
D
S
A
F
L
E
D
I
E
G
L
F
D
-
T
V
D
P
Y
G
Q
-
P
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.19
32%
25
- C2 -
-
3PJR
2
?
A:
[7-652]
---------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
L
A
H
L
-
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
-
T
H
R
I
A
Y
L
M
A
E
-
K
---
H
---------
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
-
G
-------------------------------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
-
N
R
N
F
S
I
L
D
P
T
D
Q
--
L
S
V
M
K
T
I
L
K
E
-------
K
-------
N
--------------------------------------
I
----------
D
-
P
--
K
K
F
E
P
R
T
I
----------------------------
L
--------------
G
----
T
----
I
-----------
S
A
A
K
-----------------------------
N
-------------------------
E
L
LP
P
E
Q
F
A
-----------------------------
K
----
R
--
A
S
----------------------
T
Y
Y
-----
E
--
K
V
V
S
D
V
Y
-------
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
----
M
-
T
T
I
Q
L
F
D
R
-
V
------
P
--------
D
V
L
H
Y
Y
Q
Y
K
F
-
Q
Y
----
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
----
E
---
R
F
-
Q
----
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
-----
P
-----
N
A
K
V
I
L
-----
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
------
N
V
N
R
K
P
K
-----
R
-----
I
W
T
E
-
N
-
P
------
E
--------------
G
-------
K
-------
P
I
L
--------
Y
Y
E
--
A
M
N
E
A
D
----
E
A
Q
F
V
A
G
R
I
-----------
R
E
A
V
E
-------------
R
---------------
G
E
R
R
Y
R
D
F
----------
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
-
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
-
N
V
P
K
R
G
I
G
A
-----
S
T
I
D
K
L
V
R
YA
A
-------
D
H
E
L
S
-
L
F
E
A
L
G
E
L
E
M
I
------
G
L
G
A
----
K
-
A
A
--
G
A
---
L
A
A
------------
F
R
S
Q
L
-
E
----
Q
W
T
Q
L
--
Q
E
-------
Y
V
S
V
T
E
L
V
E
--
E
--
V
--
L
D
-
K
S
G
Y
R
E
M
L
K
A
E
R
-
T
I
E
A
----------
Q
S
R
L
E
N
----
L
D
E
F
L
S
V
T
-
K
---------
H
F
E
N
VSDD------------------
K
-------
S
-----
L
I
A
F
L
T
D
L
A
L
--------
I
----
S
----
D
L
DET---------
E
------
Q
A
A
E
G
--
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
-----
E
G
-----------------------------
I
F
P
-----
H
-----
N
R
S
L
E
-----------------------------------
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
------
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
-----
F
L
N
E
I
P
A
H
L
L
-
E
T
A
S
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.80
32%
14
- C2 -
-
1QHG
1
PCRA_GEOSE
A:
[7-651]
---------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
L
A
H
L
-
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
-
T
H
R
I
A
Y
L
M
A
E
-
K
---
H
---------
V
A
P
-
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
-
G
-------------------------------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
-
N
R
N
F
S
I
L
D
P
T
D
Q
--
L
S
V
M
K
T
I
L
K
E
-------
K
-------
N
--------------------------------------
I
----------
D
-
P
--
K
K
F
E
P
R
T
I
----------------------------
L
--------------
G
----
T
----
I
-----------
S
A
A
K
-----------------------------
N
-------------------------
E
L
LP
P
E
Q
F
A
-----------------------------
K
----
R
---------------------------
Y
Y
-----
E
--
K
V
V
S
D
V
Y
-------
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
----
M
-
T
T
I
Q
L
F
D
R
-
V
------
P
--------
D
V
L
H
Y
Y
Q
Y
K
F
-
Q
Y
----
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
----
E
---
R
F
-
Q
----
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
-----
P
-----
N
A
K
V
I
L
-----
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
------
N
V
N
R
K
P
K
-----
R
-----
I
W
T
E
-
N
-
P
------
E
--------------
G
-------
K
-------
P
I
L
--------
Y
Y
E
--
A
M
N
E
A
D
----
E
A
Q
F
V
A
G
R
I
-----------
R
E
A
V
E
-------------
R
---------------
G
E
R
R
Y
R
D
F
----------
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
-
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
-
N
V
P
K
R
G
I
G
A
-----
S
T
I
D
--------------------
L
F
E
A
L
G
E
L
E
M
I
------
G
L
G
A
----
K
-
A
A
--
G
A
---
L
A
A
------------
F
R
S
Q
L
-
E
----
Q
W
T
Q
L
--
Q
E
-------
Y
V
S
V
T
E
L
V
E
--
E
--
V
--
L
D
-
K
S
G
Y
R
E
M
L
K
A
E
R
-
T
I
E
A
----------
Q
S
R
L
E
N
----
L
D
E
F
L
S
V
T
-
K
---------
H
F
E
N
V
SDD------------------
K
-------
S
-----
L
I
A
F
L
T
D
L
A
L
--------
I
----
S
-----------------------------
G
--
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
-----
E
G
-----------------------------
I
F
P
-----
H
-----
N
R
S
L
E
-----------------------------------
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
------
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
-----
F
L
N
E
I
P
A
H
L
L
-
E
T
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
75.61
28%
23
- C2 -
-
4C2U
2
?
A:
[7-654]
--------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
L
L
Q
A
L
-
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
-
I
Y
R
I
A
H
L
I
-
G
-
H
Y--
G
---------
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
---------------------------------------
G
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
-
F
V
I
Y
D
D
D
D
Q
--
L
-
D
I
I
K
E
V
M
G
-------
S
--
I
P
G
------------------------------------------------------
E
T-
Q
P
R
V
I
R
G
I
----------------------------
I
--------------
D
----
R
----
A
-----------
K
S
N
L
-----------------------------
W
-------------------------
T
P
--
D
D
L
D
R
-----------------------------
S
----
R
--
E
P
F---------------------
I
S
G
-----
L
P
R
D
A
A
A
E
A
Y
-------
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
-
L
----
I
-
T
E
T
V
R
L
F
K
-
E
------
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
----
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S---
R
---
D
R
-
N
----
L
L
V
-
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
-----
P
-----
D
A
K
V
Y
M
-----
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
------
N
T
E
R
L
D
K
-----
T
-----
L
K
P
V
-
K
-
E
------
A
--------------
G
------
Q
P
-------
V
T
F
--------
H
R
A
--
T
-
D
H
R
A
----
E
G
D
Y
V
A
D
W
L
-----------
T
R
L
H
G
-------------
E
---------------
G
R
A
W
S
-
E
M
----------
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
-
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
-
G
R
P
R
R
G
I
G
D
-----
T
A
L
Q
K
L
----
M
-------
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
------
A
E
Q
N
----
I
L
D
R
--
G
A
H
K
A
T
E
F
A
G
L
---------
M
E
A
M
S
-
E
----
A
---
A
D-
N
Y
-------
E
P
A
A
F
--
L
R
F
V
M
--
E
--
T
S
-
G
Y
L
-
D
L
L
R
Q
E
---
G
Q
E
G
----------
Q
V
R
L
E
N
----
L
E
E
L
V
S
A
A
E
E
W
S
Q
DEANV-
G
-------------------------
G
-------
S
-----
I
A
D
F
L
D
D
A
A
L
----
L
S
S
V
D
----
D
M
R
T
K
A
E
------------
N
------
K
G
A
P
E
--
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
-----
Q
G
-----------------------------
L
L
P
-----
S
-----
K
G
A
I
A
E
----------------------------------
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
------
A
A
Q
N
R
M
-
Q
F
G
----
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
-
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
74.19
29%
12
- C2 -
-
1UAA
1
REP_ECOLI
A:
[2-640]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
-
N
P
G
Q
Q
Q
A
V
E
F
-
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
-
T
N
K
I
A
H
L
I
-
R
-
G
C--
G
---------
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
G
-
R
K------------------------------------
E
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
-
F
S
L
F
D
D
T
D
Q
--
L
-
A
L
L
K
E
L
T
E
-------
G
--
L
I
E
-----------------------------------------
D
----------
D
-
K
V
-
L
L
Q
Q
L
I
S
T
----------------------------
I
--------------
S
----
N
----
W
-----------
K
N
D
L
-----------------------------
K
-------------------------
T
P
--
S
Q
A
A
A
-----------------------------
S
----
A
---------------------------
I
G
-----
E
R
D
R
I
F
A
H
C
Y
-------
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
-
L
----
I
-
L
L
P
T
L
L
L
Q
-
A
------
N
--------
E
E
V
R
K
R
W
Q
N
K
I
R
Y
----
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G---
S
---
R
A
-
R
----
F
T
V
-
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
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N
L
V
L
L
S
Q
D
F
-----
P
-----
A
L
K
V
I
K
-----
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
------
N
P
H
V
F
E
K
-----
R
-----
L
F
S
E
-
L
-
G
------
Y
--------------
G
------
A
E
-------
L
K
V
--------
L
S
A
--
N
-
N
E
E
H
----
E
A
E
R
V
T
G
E
L
-----------
I
A
H
H
F
V
------------
N
---------------
K
T
Q
Y
K
-
D
Y
----------
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
-
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
-
N
T
P
K
R
E
I
G
P
-----
A
T
L
K
K
L
----
G
-------
E
W
A
M
T
R
N
K
S
M
F
T
A
S
F
D
M
GLSQTL
S
G
R
G
----
Y
-
E
A
--
L
T
R
F
-
T
H
W
------------
L
A
E
I
Q
-
R
L
AER
E
---
P
--
I
A
-------
A
V
R
D
L
------
I
--
H
--
G
M
-
D
Y
E
-
S
W
L
Y
E
T
S
P
S
P
K
A
A
----------
E
M
R
M
K
N
----
V
N
Q
L
F
S
W
M
T
E
M
L
E
GSELDE
P
-------------------------
M
-------
T
-----
L
T
Q
V
V
T
R
F
T
L
----
R
D
M
M
E
----
R
--------------------------
E
E
E
L
--
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
-----
E
G
-----------------------------
F
L
P
-----
H
-----
Q
S
S
I
D
------------------------------------
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
------
L
C
K
E
R
R
-
Q
Y
G
----
E
L
V
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
-
I
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.47
30%
19
- C2 -
-
1UAA
1
REP_ECOLI
A:
[3-640]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
N
P
G
Q
Q
Q
A
V
E
F
-
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
-
T
N
K
I
A
H
L
I
-
R
-
G
C--
G
---------
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
G
R
K
-------------------------------------
E
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
-
F
S
L
F
D
D
T
D
Q
--
L
-
A
L
L
K
E
L
T
E
-------
G
LI
E
D
D
--
K
--------------------------------------
V
----------
L
--------
L
Q
Q
L
----------------------------
I
--------------
S
----
T
----
I
-----------
S
N
W
K
-----------------------------
N
-------------------------
D
L
--
K
T
P
S
Q
-----------------------------
A
----
A
--
A
S
----------------------
A
I
G
-----
E
R
D
R
I
F
A
H
C
Y
-------
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
-
L
----
I
-
L
L
P
T
L
L
L
Q
A
N
------
E
--------
E
V
R
K
R
W
-
Q
N
K
I
R
Y
----
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
----
G
S--
R
A
-
R
----
F
T
V
-
V
G
D
D
D
Q
S
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S
W
R
G
A
R
P
Q
N
L
V
L
L
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D
F
-----
P
-----
A
L
K
V
I
K
-----
L
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Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
------
N
P
H
V
F
E
K
-----
R
-----
L
F
S
E
-
L
-
G
------
Y
--------------
G
------
A
E
-------
L
K
V
--------
L
S
A
--
N
-
N
E
E
H
----
E
A
E
R
V
T
G
E
L
-----------
I
A
H
H
F
-------------
V
---------------
N
K
T
Q
Y
K
D
Y
----------
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
-
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
-
E
I
G
P
-----
A
T
L
K
K
L
----
G
E
W
A
M
T
R
N
K
S
M
F
T
-
A
S
F
D
M
G
L
S
Q
T
L
------
S
G
R
G
----
Y
-
E
A
--
L
T
---
R
F
T
H
-----------
W
L
A
E
I
-
Q
----
R
---
L
AE
R
E
-------
P
I
A
A
V
--
R
D
--
L
I
H
G
--
M
D
-
Y
E
S
-
W
L
Y
E
T
S
P
S
-
P
K
A
A
----------
E
M
R
M
K
N
-------
V
N
Q
L
------------
F
-------------------------
S
-------
W
-----
M
T
E
M
L
E
G
S
E
L
D---
E
P
M
T
L
----
T
----
Q
V
V
T
R
F
T
L
RDMMER--------
E
E
E
L
--
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
-----
E
G
-----------------------------
F
L
P
-----
H
------
Q
S
S
I
-----------------------------------
D
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
------
L
C
K
-----
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
-
I
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.26
27%
5
- C2 -
-
4C30
1
?
A:
[9-648]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
A
L
-
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
-
I
Y
R
I
A
H
L
I
-
G
-
H
Y--
G
---------
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
-
G
H
L
V
-
P
-------------------------------------
G
A
G
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
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R
R
G
F
V
I
Y
D
D
D
D
Q
--
L
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D
I
I
K
E
V
M
G
SIPGIGA
E
--
T
Q
P
--
R
--------------------------------------
V
----------
I
-
R
--
G
I
I
D
R
A
K
S
----------------------------
N
--------------
L
----
W
----
T
-----------
P
D
D
L
-----------------------------
D
-------------------------
R
S
--
R
E
P
----------------------------------------
P
--------------------------------
R
D
A
A
A
E
A
Y
-------
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
-
L
----
I
-
T
E
T
V
R
L
F
K
-
E
------
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
----
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
----
S
---
R
D
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R
N---
L
L
V
-
V
G
D
P
D
Q
S
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K
F
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G
A
D
I
Q
N
I
L
D
F
Q
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D
Y
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P
-----
D
A
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Y
M
-----
L
E
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N
Y
R
S
S
A
R
V
L
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A
A
N
K
L
I
E
N
------
N
T
E
R
L
D
K
-----
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-----
L
K
P
V
-
K
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------
A
--------------
G
------
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P
-------
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--------
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R
A
--
T
-
D
H
R
A
----
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G
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A
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L
-----------
T
R
L
H
G
-------------
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---------------
G
R
A
W
S
-
E
M
----------
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
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P
A
R
I
V
G
-
G
V
G
F
Y
D
R
R
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R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
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I
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G
R
----
P
R
R
-----
G
I
G
D
T
A
----
L
-------
Q
K
L
M
E
-
W
A
R
T
---------------
H
H
----
T
-
S
V
--
L
T
---
A
C
A
------------
N
---------------------------
A
H
K
A
--
T
E
--
F
--
A
G
L
M
E
-
A
M
S
-
E
A
A
D
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N
Y
E
-
P
A
A
F
----------
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
G
Q
E
---------
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
D
EA-----------------
I
A
D
F
L
D
D
A
A
L
LSSV
D
D
M
R
T
----
K
----
A
E
----------------------
P
E
--
D
A
V
T
L
M
T
L
H
N
A
K
G
L
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F
P
V
V
F
I
V
G
V
E
-----
Q
G
-----------------------------
L
L
P
-----
S
K
G
---
A
I
A
E
G
-----------------------------------
P
-
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
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A
-----
A
Q
N
R
M
Q
-
F
G
K
T
N
A
A
E
-----
D
S
A
F
L
E
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
69.70
24%
9
* C2 *
-
4CEJ
1
ADDA_BACSU
A:
[10-922]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
-
T
D
D
Q
W
N
A
I
V
S
-
T
G
Q
D
I
L
V
A
A
A
A
G
S
G
K
T
A
V
L
-
V
E
R
M
I
R
K
I
-
T
-
A
EE
N
P
---------
I
D
V
D
R
L
L
V
V
T
F
T
N
A
S
A
A
E
M
K
H
R
I
A
E
A
L
E
-
K
E
L
V
Q
R
PGS
L
H
I
R
R
Q
L
S
---------------------
L
L
N
R
A
S
I
S
T
L
H
S
F
C
L
Q
V
L
K
K
Y
Y
Y
L
I
D
L
D
P
G
-
F
R
I
A
D
Q
T
E
G
--
E
-
L
I
G
D
E
V
L
D
-------
E
--
L
F
E
D
-
E
Y
A
K
GE
K
A
F
F
E
L
V
D
R
YTTDRHD
L
D
L
Q
F
L
V
K
Q
V
Y
E
Y
S
R
S
H
P
----------
N
-
P
E
A
W
L
E
S
F
V
H
L
----------------------------
Y
DVSEKSAIEELPFY
Q
----
Y
V
K
E
D
I
A
M
V
L
N
G
A
----
K
E
K
L
L
R
A
L
E
L
T
K
APGGPAPR
A
D
N
F
L
D
D
L
A
Q
I
D
E
L
I
Q
H
Q
DD
F
S
E
L
Y
K
R
V
PA
V
S
F
K
R
AK
A
V
K
G
--
D
E
F
D
P
A
L
L
D
E
A
T
D
L
R
N
------------------
G
A
K
K
L
L
--
E
K
L
K
T
D
YFTRS
P
E
Q
H
L
K
S
L
A
E
M
K
P
V
I
E
-----
T
L
V
Q
L
V
I
S
Y
G
-------
K
R
F
E
A
A
K
Q
E
K
S
I
I
D
F
S
D
-
L
----
E
-
H
Y
C
L
A
I
L
T
-
A
------
E
NDKG
E
R
E
P
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
----
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S---
G
PEE
T
G
-
N
----
L
F
M
-
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
-----
T
ESGEG
T
G
R
K
I
D
-----
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
------
L
M
G
G
K
I
G
EVDYD
E
QAELK
L
G
A
A
Y
P
D
N
------
D
--------------
E
------
T
E
T
E
L
L
L
I
D------------
E
L
--
E
-
T
V
Q
F
----
E
A
K
A
I
A
K
E
I
-----------
R
K
L
I
S
S
P
F
K
V
Y
DGKKK
T
H
R
---------------
N
I
Q
Y
R
-
D
I
----------
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
S
V
L
-
R
S
P
I
V
G
A
D
E
-----
N
E
L
S
L
I
----
R
-------
L
E
N
-
K
-
K
A
P
Y
Y
E
A
M
K
D
Y
------
L
A
A
G
DRSD
E
-
L
Y
Q
K
L
N
T
F
-
Y
G
H
------------
L
Q
K
W
R
-
A
----
F
S
--
K
--
N
H
-------
S
V
S
E
L
--
I
W
E
V
Y
--
R
--
D
T
-
K
Y
M
-
D
Y
V
G
G
M
----
P
G
G
----------
K
Q
R
Q
A
N
----
L
R
V
L
Y
D
R
A
R
Q
Y
E
S
T
A----
F
-------------------------
R
-------
G
-----
L
F
R
F
L
R
F
I
E
R
----
M
Q
E
R
G
D
D
L
G
T
----
A
R
------------
G
------
L
S
E
Q
E
--
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
G
-----
R
N
------------------------------
F
N
-----
M
-----
M
D
L
N
K
S
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
T
L
P
L
I
A
M
K
K
K
M
R
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
I
------
G
S
C
K
D
H
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
69.42
22%
-7
- C2 -
-
1W36
-
RECB_ECOLI
B:
[2-823]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
-
V
A
E
T
L
D
P
L
R
L
P
L
Q
G
E
R
L
I
E
A
S
A
G
T
G
K
T
F
T
I
-
A
A
L
Y
L
R
L
L
-
L
-
G
---
L
GGSAAFPRP
L
T
V
E
E
L
L
V
V
T
F
T
E
A
A
T
A
E
L
R
G
R
I
R
S
N
I
H
-
E
LRIACLRETTDNPLYERLLEEIDDKAQAAQWLLLAER
Q
M
D
E
A
A
V
F
T
I
H
G
F
C
Q
R
M
L
N
L
N
A
F
E
S
G
M
L
F
E
-
Q
Q
L
I
E
D
E
S
L
LR
Y
-
Q
A
C
A
D
F
W
R
-------
R
--
H
C
Y
PL
P
--------------------------------------
R
EIAQVVFETW
K
G
P
QA
L
L
R
D
I
N
R
Y
LQGEAPVIKAPPPDDETLASRHAQIVAR
I
--------------
D
TVKQ
Q
----
W
RDAVGELDALI
E
S
S
G
-----------------------------
I
-------------------------
D
R
--
R
K
F
N
R
SNQAKWIDKISAWAEEETNSYQLPESLEK------PR
H
P
LFEAIDQLLAEPLSI-------
R
D
L
-----
V
I
T
R
A
L
A
E
I
R
-------
E
T
V
A
R
E
K
R
R
R
G
E
L
G
F
D
D
-
M
----
L
-
S
R
L
D
S
A
L
R
-
S
------
E
SG------
E
V
L
A
A
A
I
R
T
R
F
P
V
----
A
M
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
H---
H
QP-
E
T
-
A
----
L
L
L
-
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
I
F
T
Y
M
K
A
R
S
E
V
------------
H
A
H
Y
T
-----
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
------
T
D
D
A
F
M
F
REI--
P
-----
F
I
P
V
-
K
-
S
------
A
GKNQALRFVFKGET
Q
------
P
A
-------
M
K
M
WLMEGESC
G
V
G
--
D
-
Y
Q
S
T
----
M
A
Q
V
C
A
A
Q
I
-----------
R
D
W
L
Q
-------------
A
GQRGEALLMNGDDAR
P
V
R
A
S
-
D
I
----------
S
V
L
V
R
S
R
Q
E
A
A
Q
V
R
D
A
L
T
L
L
E
I
P
S
V
Y
L
S
N
R
D
S
V
F
E
T
L
E
A
Q
E
M
L
W
L
L
Q
A
V
M
T
P
E
R
E
N
T
L
R
S
A
L
-
A
T
S
M
M
G
L
N
A
-----
L
D
I
E
T
L
----
N
-------
N
D
E
-----
H
A
W
D
V
V
V
E
E
------
F
------------------
D
G
Y
------------
R
Q
I
W
R
-
K
R---
G
---
V
--
M
P
-------
M
L
R
A
L
------
M
--
S
--
A
R
-
N
I
A
-
E
N
L
L
A
T
----
A
G
G
----------
E
R
R
L
T
D
----
I
L
H
I
S
E
L
L
Q
E
AGTQ-----
L
-------------------------
E
-------
S
-----
E
H
A
L
V
R
W
L
S
Q
----
H
I
L
E
P
----
D
----
S
N
------------
A
SSQQMR
L
E
S
D
K
--
H
L
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
V
W
L
P
F
I
T
NFRVQ
E
Q
-----------------------------
A
F
Y
-----
H
-----
D
R
H
S
F
EAVLDLNAAPESVDLA-------------------
E
A
E
R
L
A
E
D
L
R
L
L
Y
V
A
L
T
R
S
V
W
H
C
S
L
G
------
V
A
P
L
V
R
-
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.25
23%
0
- C- -
-
3U4Q
-
ADDA_BACSU
A:
[304-930]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
T
D
L
----------------------------
R
--------------
N
----
G
----
A
-----------
K
K
L
L
-----------------------------
E
-------------------------
K
L
--
K
T
D
Y
F
-----------------------------
T
----
R
--
S
P
----------------------
E
Q
H
L
K
S
L
A
E
M
K
P
V
I
E
T
L
V
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
K
S
I
I
D
F
S
D
-
L
E
H
Y
C
L
-
A
I
L
T
A
E
N
D
------------------
R
E
P
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
----
S
---
G
P
-
E
ET
G
N
L
F
M
-
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
-----
T
-----
E
S
G
E
G
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
MGGKI
G
E
V
D
Y
D
E
-----
Q
-----
A
E
L
K
-
L
-
G
------
A
--------------
A
YPDNDE
T
E
-------
T
E
L
--------
L
L
I
--
D
---
L
E
T
V
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
S
S
PFKVY-
K
K
T
H
-------------
R
---------------
N
I
Q
Y
R
-
D
I
----------
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
---------------------
A
S
V
L
----
R
-------
S
P
I
V
G
-
A
D
E
N
E
L
S
L
I
R
L
------
E
-
N
K
----
K
-
A
P
--
Y
Y
---
E
A
M
K
D
Y
L
A
A
GDRSD
E
L
Y
Q
K
L
-
N
----
T
---
F
--
Y
G
-------
H
L
Q
K
W
--
R
A
--
F
--
S
--
K
N
H
S
V
S
-
E
L
I
W
E
V
Y
R
-
D
T
K
Y
M
D
Y
V
G
G
M
PG
G
K
Q
R
Q
A
N
----
L
R
V
L
Y
D
R
A
R
Q
---------
Y
-------------------------
E
-------
S
TAFRG
L
F
R
F
L
R
-----------
F
I
----
E
----
R
M
------------
Q
------
E
R
G
D
-QE
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
G
-----
R
N
FNMMDLNKS
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
-----
T
L
P
L
I
A
M
K
K
K
M
-----------------------------------
R
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.25
23%
0
- C- -
-
3U44
-
ADDA_BACSU
A:
[304-930]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
T
D
L
----------------------------
R
--------------
N
----
G
----
A
-----------
K
K
L
L
-----------------------------
E
-------------------------
K
L
--
K
T
D
Y
F
-----------------------------
T
----
R
--
S
P
----------------------
E
Q
H
L
K
S
L
A
E
M
K
P
V
I
E
T
L
V
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
K
S
I
I
D
F
S
D
-
L
E
H
Y
C
L
-
A
I
L
T
A
E
N
D
------------------
R
E
P
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
----
S
---
G
P
-
E
ETGN
L
F
M
-
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
-----
T
-----
E
S
G
E
G
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
MGGKI
G
E
V
D
Y
D
E
-----
Q
-----
A
E
L
K
-
L
-
G
------
A
--------------
A
YPDNDE
T
E
-------
T
E
L
--------
L
L
I
--
D
---
L
E
T
V
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
S
S
PFKVY-
K
K
T
H
-------------
R
---------------
N
I
Q
Y
R
-
D
I
----------
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
---------------------
A
S
V
L
----
R
-------
S
P
I
V
G
-
A
D
E
N
E
L
S
L
I
R
L
------
E
-
N
K
----
K
-
A
P
--
Y
Y
---
E
A
M
K
D
Y
L
A
A
GDRSD
E
L
Y
Q
K
L
-
N
----
T
---
F
--
Y
G
-------
H
L
Q
K
W
--
R
A
--
F
--
S
--
K
N
H
S
V
S
-
E
L
I
W
E
V
Y
R
-
D
T
K
Y
M
D
Y
V
G
G
MPG
G
K
Q
R
Q
A
N
----
L
R
V
L
Y
D
R
A
R
Q
---------
Y
-------------------------
E
-------
S
TAFRG
L
F
R
F
L
R
-----------
F
I
----
E
----
R
M
------------
Q
------
E
R
G
D
-QE
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
G
-----
R
N
FNMMDLNKS
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
-----
T
L
P
L
I
A
M
K
K
K
M
-----------------------------------
R
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
58.44
34%
2
- C2 -
-
2PJR
2
?
F:
[7-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
L
A
H
L
-
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
-
T
H
R
I
A
Y
L
M
A
E
-
K
---
H
---------
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
-
G
-------------------------------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
-
N
R
N
F
S
I
L
D
P
T
D
Q
--
L
S
V
M
K
T
I
L
K
E
-------
K
-------
N
--------------------------------------
I
----------
D
-
P
--
K
K
F
E
P
R
T
I
----------------------------
L
--------------
G
----
T
----
I
-----------
S
A
A
K
-----------------------------
N
-------------------------
E
L
LP
P
E
Q
F
A
-----------------------------
K
----
R
--
A
S
----------------------
T
Y
Y
-----
E
--
K
V
V
S
D
V
Y
-------
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
----
M
-
T
T
I
Q
L
F
D
R
-
V
------
P
--------
D
V
L
H
Y
Y
Q
Y
K
F
-
Q
Y
----
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
----
E
---
R
F
-
Q
----
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
-----
P
-----
N
A
K
V
I
L
-----
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
------
N
V
N
R
K
P
K
-----
R
-----
I
W
T
E
-
N
-
P
------
E
--------------
G
-------
K
-------
P
I
L
--------
Y
Y
E
--
A
M
N
E
A
D
----
E
A
Q
F
V
A
G
R
I
-----------
R
E
A
V
E
-------------
R
---------------
G
E
R
R
Y
R
D
F
----------
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
-
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
-
N
V
P
K
R
G
I
G
A
-----
S
T
I
D
K
L
----
V
-------
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.72
34%
6
- C2 -
-
2PJR
1
?
A:
[7-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
L
A
H
L
-
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
-
T
H
R
I
A
Y
L
M
A
E
-
K
---
H
---------
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
-
G
-------------------------------------
A
A
E
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
-
N
R
N
F
S
I
L
D
P
T
D
Q
--
L
S
V
M
K
T
I
L
K
E
-------
K
-------
N
--------------------------------------
I
----------
D
-
P
--
K
K
F
E
P
R
T
I
----------------------------
L
--------------
G
----
T
----
I
-----------
S
A
A
K
-----------------------------
N
-------------------------
E
L
LP
P
E
Q
F
A
-----------------------------
K
----
R
--
A
S
----------------------
T
Y
Y
-----
E
--
K
V
V
S
D
V
Y
-------
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
----
M
-
T
T
I
Q
L
F
D
R
-
V
------
P
--------
D
V
L
H
Y
Y
Q
Y
K
F
-
Q
Y
----
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
----
E
---
R
F
-
Q
----
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
-----
P
-----
N
A
K
V
I
L
-----
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
------
N
V
N
R
K
P
K
-----
R
-----
I
W
T
E
-
N
-
P
------
E
--------------
G
-------
K
-------
P
I
L
--------
Y
Y
E
--
A
M
N
E
A
D
----
E
A
Q
F
V
A
G
R
I
-----------
R
E
A
V
E
-------------
R
---------------
G
E
R
R
Y
R
D
F
----------
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
-
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
-
N
V
P
K
R
G
I
G
A
-----
S
T
I
D
K
L
----
V
-------
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
51.38
20%
25
- C2 -
-
3U4Q
-
ADDA_BACSU
A:
[10-1232]
TWT
D
D
Q
W
N
A
I
VSTG
Q
D
I
L
V
AAAAGSG
K
T
A
V
L
V
E
R
M
I
R
K
I
T
AEE
N
P
I
D
VDR
L
L
V
V
T
FT
N
A
S
A
A
E
M
K
H
R
I
A
E
A
L
E
K
E
L
V
Q
R
PGS
L
H
I
R
R
Q
L
S
L
L
NRAS
I
S
T
L
H
S
F
C
L
Q
V
L
K
K
YYYLIDLDPG
F
R
I
A
D
Q
T
E
G
E
L
I
G
D
E
V
L
D
E
L
F
E
D
E
Y
A
K
G
E
K
A
F
F
E
L
V
D
R
Y
T
T
D
R
H
D
L
D
L
Q
F
-
L
V
K
Q
V
Y
E
Y
S
R
S
H
P
N
P
E
A
W
L
E
S
F
V
H
L
Y
D
V
-
S
-
E
---
K
---------
S
A
I
E
E
L
P
F
Y
Q
Y
V
K
E
D
I
A
M
V
L
N
G
A
K
E
K
L
L
-
R
-------------------------------------
A
L
E
L
T
D
N
F
L
D
D
L
A
Q
I
D
E
L
I
Q
H
Q
D
D
F
S
E
-
L
Y
-
K
R
V
P
A
V
S
D
P
--
A
-
L
L
D
E
A
T
D
L
-------
R
--
N
G
A
--
K
--------------------------------------
K
----------
L
-
L
--
E
K
L
K
T
D
Y
F
----------------------------
T
-------------------------------------
R
S
P
-----------------------------
E
-------------------------
Q
H
--
L
K
S
L
A
-----------------------------
E
----
M
--
K
P
----------------------
V
I
E
-----
T
L
V
Q
L
V
I
S
Y
G
-------
K
R
F
E
A
A
K
Q
E
K
S
I
I
D
F
S
D
-
L
----
E
-
H
Y
C
L
A
I
L
T
-
A
ENDREP
S
--------
E
A
A
R
F
Y
Q
E
Q
F
-
H
E
----
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
SGPE
E
---
T
G
-
N
----
L
F
M
-
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
TESGE
G
-----
T
G
R
K
I
D
-----
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
MGGKI
G
E
V
D
Y
D
E
-----
Q
-----
A
E
L
K
-
L
-
G
AAYPDN
D
--------------
E
------
T
E
-------
T
E
L
--------
L
L
I
DL
E
-
T
V
Q
F
----
E
A
K
A
I
A
K
E
I
-----------
R
K
L
I
S
-------------
S
---------------
P
F
K
V
Y
-
K
K
T
H
R
N
IQYRD
I
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
S
V
L
R
S
P
I
V
-
G
A
D
E
-----
N
E
L
S
L
I
----
R
-------
L
E
N
K
K
-
A
-
P
Y
Y
E
A
M
K
D
Y
------
L
A
A
G
----
D
-
R
S
--
D
E
---
L
Y
Q
------------
K
L
N
T
F
Y
G
----
H
---
L
--
Q
K
-------
W
R
A
F
S
--
K
N
--
H
--
S
--
V
S
-
E
L
I
-
W
E
V
Y
R
D
T
K
-
Y
M
D
Y
V
G
G
M
PG
G
---
K
Q
R
Q
A
N
----
L
R
V
L
Y
D
R
A
R
Q
---------
Y
-------------------------
E
-------
S
------
T
A
F
R
G
L
F
R
F
----
L
R
F
I
E
----
R
----
M
Q
------------
E
------
R
G
D
Q
E
--
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
G
-----
R
N
FNMMDLNKS
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
T
L
P
L
I
A
-----
M
K
K
K
M
-----------------------------------
R
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
I
G
S
C
K
D
H
Q
K
Q
L
A
K
-
W
Q
A
S
A
-
S
Q
T
D
W
L
L
P
E
F
D
R
Y
Q
A
R
T
Y
L
D
-
F
I
G
P
A
L
A
R
H
R
H
A
D
I
S
G
H
P
A
R
F
A
V
Q
M
I
H
S
Y
D
S
E
R
L
E
A
I
R
RGEPVFAF
D
E
K
A
R
E
Q
L
S
WTYPHQEVTQIRT
K
Q
S
V
SDEYSGRYRRPAFMMKKGLT
A
A
E
K
G
T
A
M
H
T
V
M
Q
H
IPLSHVPS
I
E
E
A
E
Q
T
V
H
R
L
Y
E
K
ELLT
E
E
Q
K
D
A
ID
I
E
E
I
V
Q
F
F
H
T
E
I
G
G
Q
L
I
G
AK
W
K
D
R
E
I
P
F
S
L
A
L
PAKEIYPDAHEAD
E
P
L
L
V
Q
G
I
ID
C
L
Y
E
T
ED
G
L
Y
L
L
A
Y
K
SDRIEGGF
E
G
A
A
P
I
L
K
K
R
Y
E
T
Q
I
Q
L
Y
T
K
A
V
E
Q
I
AK
T
K
V
K
G
C
A
L
Y
F
FDGG
H
I
L
T
L