@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLB2: (2017-11-01 )
MIPKSFLIYKNDKLDLCKTLAIIEERLELPSPMEQDDMAGKTLYDKLWDDHVVTQRDDGSCLLYIDRHLLHEVTSPQAFEGLQLAGRQPWRLSANVATPDHNVPTSKKERDQGIAGIEDDTSRIQVQTLDDNCKAFNIVEFGINDIRQGIVHVVGPEQGLTLPGMTVVCGDSHTATHGAFGCLAHGIGTSEVEHVLATQCLVQKKSKNMLVRVDGVLGKGVTPKDVVLAIIGKIGTAGGTGYAIEFGGQVFRDMSIEGRMTVCNMAIEAGARVGMVAVDDKTIEYVKGRSYAPKGEQWDQAVAYWNTLHSDDDAVFDAVVELNGAEIEPQVSWGTSPEMVIPVSKAVPTLEQAKDDVQRNDWTRAYQYMGLNAGQALADIQLGRVFIGSCTNSRIEDIRAAAEVVKGRKVAPSIKQAMIVPGSGLVKQQAEKEGLDKIFLEAGFEWREPGCSMCLAMNADKLQPGEHCASTSNRNFEGRQGNGGRTHLVSPAMAVAAAIAGHFVDIRSF
Atome Classification :
(20 SA)
.........10........20........30........40........50..-.------.....60....--....70........80.....-...90........100.....-..110.......120.......130.......-----140...---...---..150.......160.......170.......180.......190.......200.......210.......220.........230--.--.....------...240.......250.......260.......270-.......280.......----------290...------....300.......310-.......320.....-..330.......340.......350.......360.......370.......380.......390.......400....-...410-....---....420.......430.......440.......450.....-..460....--.--..470.......480.-.....--..--490.......500.-......-------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIP
K
S
F
L
I
Y
KND
K
L
D
L
C
K
T
L
A
I
I
E
E
R
LELPSPMEQDDMA
G
K
T
L
Y
D
K
LWDDHVV-T------QRDDG
S
C
L
L
Y
I
--
D
R
H
L
L
H
E
VTS
P
Q
A
FE
G
L
Q
LAG-RQP
W
R
L
SANVATPDHNVPTS
K
-
K
E
R
DQGIAGIEDDTS
R
I
Q
V
Q
TLDDNC
K
A
F
N
I
V
-----
E
-
F
G
I
N
---
D
I
R
---
Q
G
I
V
H
V
VGPEQGLTLP
G
M
T
V
V
CGDSHTA
T
H
G
A
F
G
C
L
A
HGI
G
T
S
E
V
E
H
V
L
A
T
Q
C
L
V
Q
KKSK
N
M
L
V
R
V
DGVLGKG--V
T
P
K
D
V
V
L
A
I
----
I
--
G
KIGT------AGGT
G
Y
A
I
EFGG
Q
V
F
R
DMSIEG
R
M
T
V
C
N
M
A
I
EAG
A
R
-
V
G
M
V
A
VDDK
T
I
E
YVKGR----------SYAPKG------
E
Q
W
D
Q
A
V
A
Y
W
N
TLHSD
D
-
D
A
V
F
D
A
V
V
ELNGAEI-
E
P
QVSWGTSP
E
M
V
I
PVSKAV
P
T
L
E
Q
A
K
D
D
V
QRN
D
W
T
R
A
Y
Q
YMGLNAG
Q
A
L
A
D
I
Q
L
G
R
V
F
IGSCTN
S
R
I
E
D
I
R
A
A
A
E
V
VK-GRKVA--PS
I
K
---
Q
A
M
IVPGS
G
L
V
K
Q
Q
A
E
KE
G
L
D
K
I
F
L
EAGFEWREPGC
S
M
C
L
AM-NADKLQPGE--H--CASTSNRNFEGRQG-N-GG
R
T
H
--LV--
S
P
A
M
A
V
A
A
A
I
A
G
H
F
-
V
DIRSF-------------------------------------------
21
HHSearch
74.85
36%
-4
- C2 -
-
4KP1
5
LEUC_METJA
A:
[23-445]
---------------------------------------
G
M
T
I
V
E
K
I
L
A
K
A
S
G
-
K
KE----
V
S
P
G
D
I
V
M
A
N
I
--
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
I
E
K
V
W
N
P
E
K
I
V
I
L
F
D
H
Q
V
P
A
D
S
-
I
K
A
-----------
A
E
N
-
H
I
L
M
R
K
F
V
K
E
Q
G
I
K
Y
----
F
-
Y
D
I
------
R
---
E
G
V
C
H
Q
V
L
P
E
K
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
--
V
T
S
K
D
V
I
L
S
I
----
I
--
G
E
V
G
V
------
D
G
A
T
Y
K
A
C
Q
F
G
G
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
-
T
G
I
I
E
P
D
E
K
T
I
Q
Y
V
K
E
A
----------
M
K
K
H
G
------------
T
E
R
P
F
E
V
I
K
G
D
E
-
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
P
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
-------------------------------
E
V
A
G
K
P
I
D
Q
V
F
I
G
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
E
K
H
G
G
I
A
--
D
D
V
R
----
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
-
L
Y
G
V
L
G
P
G
E
--
V
--
C
V
S
T
S
N
R
N
F
R
G
R
Q
G
S
L
-
E
A
E
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-
V
D
P
R
D
L
-------------------------------------------
24
HHSearch
70.84
34%
-11
- C2 -
-
4KP2
-
HACA_METJA
A:
[1-418]
----------------------------------------
M
T
L
V
E
K
I
L
S
K
K
V
G
Y
E
------
V
C
A
G
D
S
I
E
V
E
V
--
D
L
A
M
T
H
D
G
T
T
P
L
A
Y
K
A
L
K
E
M
S
-
D
S
V
W
N
P
D
K
I
V
V
A
F
D
H
N
V
P
P
N
T
-
V
K
------------
A
A
E
M
Q
K
L
A
L
E
F
V
K
R
F
G
I
K
N----
F
-
H
K
------
G
G
---
E
G
I
C
H
Q
I
L
A
E
N
-
Y
V
L
P
N
M
F
V
A
G
G
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
F
G
A
T
D
M
A
Y
I
Y
A
T
G
E
T
W
I
K
V
P
K
T
I
R
V
D
I
V
G
K
-
N
E
N
--
V
S
A
K
D
I
V
L
R
V
----
C
--
K
E
I
G
R
------
R
G
A
T
Y
M
A
I
E
Y
G
G
E
V
V
K
N
M
D
M
D
G
R
L
T
L
C
N
M
A
I
E
M
G
G
K
-
T
G
V
I
E
A
D
E
I
T
Y
D
Y
L
K
K
E
----------
R
G
L
S
D
-------
E
-
D
I
A
K
L
K
K
E
-
R
I
T
V
N
R
D
E
A
N
Y
Y
K
E
I
E
I
D
I
T
D
M
-
E
E
Q
V
A
V
P
H
H
P
D
N
V
K
P
I
S
D
-------------------------------
V
E
G
T
E
I
N
Q
V
F
I
G
S
C
T
N
G
R
L
S
D
L
R
E
A
A
K
Y
L
K
-
G
R
E
V
H
--
K
D
V
K
----
L
I
V
I
P
A
S
K
K
V
F
L
Q
A
L
K
E
G
I
I
D
I
F
V
K
A
G
A
M
I
C
T
P
G
C
G
P
C
L
G
A
-
H
Q
G
V
L
A
E
G
E
--
I
--
C
L
S
T
T
N
R
N
F
K
G
R
M
G
H
I
-
N
S
Y
I
Y
--
L
A
--
S
P
K
I
A
A
I
S
A
V
K
G
Y
I
-
T
N
K
----------------------------------------------
2
PsiBlast_PDB
69.85
34%
-5
- C2 -
-
4KP1
5
LEUC_METJA
A:
[50-445]
-----------------------------------------------------------------------
I
--
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
I
E
K
V
W
N
P
E
K
I
V
I
L
F
D
H
Q
V
P
A
D
S
----------
I
K
A
A
E
N
H
I
L
M
R
K
F
--------
V
K
-----
E
-
Q
G
I
K
Y
F
Y
D
I
R
---
E
G
V
C
H
Q
V
L
P
E
K
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
--
V
T
S
K
D
V
I
L
S
I
----
I
--
G
E
V
G
V
------
D
G
A
T
Y
K
A
C
Q
F
G
G
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
-
T
G
I
I
E
P
D
E
K
T
I
Q
Y
V
K
-------------
E
A
M
K
K
------
H
G
T
E
R
P
---
F
E
V
I
K
G
D
E
-
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
P
----------
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
E
---------------------
V
A
G
K
P
I
D
Q
V
F
I
G
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
E
-
K
H
G
G
I
--
A
D
D
V
---
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
-
L
Y
G
V
L
G
P
G
E
--
V
--
C
V
S
T
S
N
R
N
F
R
G
R
Q
G
-
S
L
E
A
E
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-
V
D
P
R
D
L
-------------------------------------------
1
PsiBlast_PDB
67.37
34%
-2
- C2 -
-
4NQY
-
LEUC_METJA
A:
[48-442]
-----------------------------------------------------------------------
I
--
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
I
E
K
V
W
N
P
E
K
I
V
I
L
F
D
----------------------
N
H
I
L
M
R
K
F
--------
V
K
-----
E
-
Q
G
I
K
Y
F
Y
D
I
R
---
E
G
V
C
H
Q
V
L
P
E
K
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
--
V
T
S
K
D
V
I
L
S
I
----
I
--
G
E
V
G
V
------
D
G
A
T
Y
K
A
C
Q
F
G
G
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
-
T
G
I
I
E
P
D
E
K
T
I
Q
Y
V
K
-
E
----------
A
M
K
K
H
G
------
T
E
R
P
-----
F
E
V
I
K
G
D
E
-
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
P
----------
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
E
---------------------
V
A
G
K
P
I
D
Q
V
F
I
G
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
E
-
K
H
G
G
I
--
A
D
D
V
---
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
-
L
Y
G
V
L
G
P
G
E
--
V
--
C
V
S
T
S
N
R
N
F
R
G
R
Q
G
-
S
L
E
A
E
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-
V
D
P
R
D
--------------------------------------------
8
PsiBlast_PDB
65.14
26%
9
- C2 -
-
5ACN
2
ACON_PIG
A:
[21-476]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
RP
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
-
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
15
PsiBlast_PDB
64.91
25%
8
- C2 -
-
1NIS
2
ACON_BOVIN
A:
[21-476]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
-
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
4
PsiBlast_PDB
64.82
26%
10
- C2 -
-
1C97
3
ACON_BOVIN
A:
[20-475]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
RP
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
-
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
18
PsiBlast_PDB
64.75
25%
9
- C2 -
-
1AMJ
1
ACON_BOVIN
A:
[21-476]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
-
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
3
PsiBlast_PDB
64.75
33%
16
- C2 -
-
4KP2
-
HACA_METJA
A:
[26-417]
-----------------------------------------------------------------------
V
--
D
L
A
M
T
H
D
G
T
T
P
L
A
Y
K
A
L
K
E
M
S
-
D
S
V
W
N
P
D
K
I
V
V
A
F
D
H
N
V
P
P
--------------
N
T
V
K
A
A
E
M
Q
K
L
-----
A
L
E
F
V
-----
K
R
F
G
I
K
---
N
F
H
KGG
E
G
I
C
H
Q
I
L
A
E
N
-
Y
V
L
P
N
M
F
V
A
G
G
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
F
G
A
T
D
M
A
Y
I
Y
A
T
G
E
T
W
I
K
V
P
K
T
--
I
R
V
D
-
I
V
G
K
N
EN
V
S
A
K
D
I
V
L
R
V
----
C
--
K
E
I
G
R
------
R
G
A
T
Y
M
A
I
E
Y
G
G
E
V
V
K
N
M
D
M
D
G
R
L
T
L
C
N
M
A
I
E
M
G
G
K
-
T
G
V
I
E
A
D
E
I
T
Y
D
Y
L
K
-
K
----------
E
R
G
L
S
D
------
E
D
I
A
K
L
K
K
E
R
I
T
V
N
R
-
D
-
E
A
N
Y
Y
K
E
I
E
I
D
I
T
D
M
-
E
E
Q
V
A
V
P
H
H
P
D
N
V
K
P
I
S
-----------
D
V
E
G
T
--------------------
E
I
N
Q
V
F
I
G
S
C
T
N
G
R
L
S
D
L
R
E
A
A
K
Y
L
K
-
G
R
E
V
H
--
K
D
V
K
----
L
I
V
I
P
A
S
K
K
V
F
L
Q
A
L
K
E
G
I
I
D
I
F
V
K
A
G
A
M
I
C
T
P
G
C
G
P
C
L
G
A
-
H
Q
G
V
L
A
E
G
E
--
I
--
C
L
S
T
T
N
R
N
F
K
G
R
M
G
-
H
I
N
S
Y
I
Y
--
L
A
--
S
P
K
I
A
A
I
S
A
V
K
G
Y
I
-
T
N
-----------------------------------------------
25
HHSearch
64.56
23%
0
- C2 -
-
1L5J
1
ACNB_ECOLI
B:
[356-826]
--------------
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
G
R
A
C
G
-
V
KG----
I
R
P
G
A
Y
C
E
P
K
M
--
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
-
C
L
G
F
S
A
D
L
V
M
Q
S
F
C
H
T
A
A
Y
P
K
-
P
V
D
------------
V
N
T
H
H
T
L
P
D
F
I
M
N
R
G
G
V
-----
S
-
L
R
------
P
G
---
D
G
V
I
H
S
W
L
N
R
--
M
L
L
P
D
T
V
G
T
G
G
D
S
H
T
R
F
P
I
---
G
I
S
F
P
A
G
S
G
L
V
A
F
A
A
A
T
G
V
M
P
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
--
I
T
L
R
D
L
V
H
A
I
PLYA
I
KQ
G
L
L
T
V
EKKGKK
N
I
F
S
G
R
I
L
E
I
E
G
--
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
IVLLKWMIAE
G
Y
G
D
R
R
TLERRI
Q
G
M
E
K
W
L
A
N
P
E
L
L
E
A
D
A
-
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
-------------------------------
V
Q
G
E
K
I
D
E
V
F
I
G
S
C
M
T
-
N
I
G
H
F
R
A
A
G
K
L
L
D
-
A
H
K
G
Q
--
L
P
T
R
----
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
N
--
Q
A
R
V
A
D
G
A
--
T
--
V
V
S
T
S
T
R
N
F
P
N
R
L
G
-
T
-
G
A
N
V
F
--
L
A
--
S
A
E
L
A
A
V
A
A
L
I
G
K
L
-
P
T
P
E
E
Y
-------------------------------------------
11
PsiBlast_PDB
64.54
26%
10
- C2 -
-
1B0M
1
ACON_PIG
A:
[20-475]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
RP
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
-
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
7
PsiBlast_PDB
64.53
26%
13
- C2 -
-
1B0J
2
ACON_PIG
A:
[21-476]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
RP
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
-
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
16
PsiBlast_PDB
64.44
25%
9
- C2 -
-
1NIT
1
ACON_BOVIN
A:
[21-476]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
-
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
13
PsiBlast_PDB
64.44
25%
9
- C2 -
-
1FGH
1
ACON_BOVIN
A:
[21-476]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
-
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
14
PsiBlast_PDB
64.40
25%
10
- C2 -
-
8ACN
2
ACON_BOVIN
A:
[21-476]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
-
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
5
PsiBlast_PDB
64.26
26%
11
- C2 -
-
1B0K
2
ACON_PIG
A:
[20-475]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
RP
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
-
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
12
PsiBlast_PDB
63.94
25%
11
- C2 -
-
1ACO
1
ACON_BOVIN
A:
[21-476]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
-
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
10
PsiBlast_PDB
63.91
26%
8
- C2 -
-
7ACN
2
ACON_PIG
A:
[21-476]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
-
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
31
Fugue
63.24
23%
15
- C2 -
-
1ACO
1
?
?:
[2-528]
--
R
A
K
V
A
M
S
H
F
E
P
H
E
Y
I
R
----
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
-
D
PAN
Q
E
I
E
R
G
K
T
Y
L
R
L
R
P
--
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
---
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
V
---------
G
F
W
---
R
P
G
---
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
-------------
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
-
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
W
P
-----------------------
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
-
Q
A
L
A
H
GL
K
C
K
S
---
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
--
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
--
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
G
KDG
K
K
F
K
L
E
A
P
D
A
D
ELPRAEFDPGQDT
Y
Q
H
P
PKDSSG
Q
R
6
PsiBlast_PDB
63.07
26%
10
- C2 -
-
1C96
2
ACON_BOVIN
A:
[20-475]
---------------
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
-----
K
I
V
Y
G
H
L
-
D
D
P
A
N
-
Q
------
E
I
E
R
G
K
T
Y
L
R
L
RP
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-
L
P
K
V
A
V
P
S
T
I
H
C
-
D
H
L
I
---------
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
----
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
---
F
W
R
PG-
S
G
I
I
H
Q
I
I
L
E
N
-
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
--
T
S
P
K
D
V
I
L
K
V
----
A
--
G
I
L
T
V
------
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
-
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
-------------
S
K
T
G
R
A
------
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
-
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
-------
K
E
G
W
P
--------------
L
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
--
Q
A
L
A
--
H
G
L
K
CK
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
E
--
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
-
A
-
N
P
E
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------