@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLD1: (2017-11-01 )
MTKNASSPGKRFMKLAGMTASIATKTVSNSIRNLTADEEQKLAAKTKLFQDIGLQIADTLGEMKGAVMKVGQIASQYKDIFPPEVAKAISKLQRQAPAMPFSAIQQQVERELGKPLNAAFKSFDEQPFAAASIGQVHKAVLPNGQQVVVKVQYPGVDEACESDLKQVRLALRLMGVLKIDKKLQDQLFAEIQDSLSAELNYEIEAQNLEVFKTFHSKLDDKIIIPTVYKDYSSRRILTLSLEQGDSIETASSWPIEIRNTIGRRLIRALGQEMFFLKRFHCDPHPGNFAFRQDGSVIIYDYGSVKTLSNEIVYSFKRLVNAARHEDIDLIETELLELHSLAEKGKFPSDLYKLWIEVLLRPLTTTYDFAENSSQHDGMLLVKKSLKYWDVFKPSPDTLMVNRTISGHYWNLIHLKVHDNLNDLFKELVPLSN
Atome Classification :
(20 SA)
-------------------------.........10........20........30........40........50.---.......60........70.----------.......80.-........90........100.......110-....-....120...--------....130.......140------.----.......150.......160.......170.......180.......--190---.........200.-------......210......-.---------220......----.230........240.......250------.------------......260.......270.....--..280....---...290.-.......300.......310.......320...--------....330...--....340-..----...--...350.......360...--.....370.......380.....---..390.......-400.......410........420.......430------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------MTKNASS
P
G
K
R
F
M
K
L
AGM
T
A
S
I
A
T
K
T
V
S
N
S
I
RNLT
A
D
E
E
Q
K
L
A
A
K
T
K
L
F
Q
D
I
---
G
L
Q
I
A
D
T
L
G
E
M
K
G
A
V
M
K
V
G
Q
----------
I
A
S
Q
Y
KDI-F-
P
P
E
V
A
K
A
I
S
K
L
Q
R
QAPAM
P
F
S
A
I
Q
Q
Q
V
E
R
-
E
-LGK
P
-
L
N
A
A
F
K
SFDE--------QPF
A
A
A
S
I
G
Q
V
H
K
A
VL-------P----NG
Q
Q
V
V
V
K
V
QYPGV
D
E
A
C
E
S
D
L
K
Q
V
R
L
A
L
R
L
M
G
V
L
K
I
D
K
K
L
Q
D
Q
L
F
A
--
E
-----
I
Q
D
S
LSAEL
N
Y
E
I
-------EA
Q
N
L
E
V
F
K
T
F
H
S
KL-D---------D
K
I
I
I
P
T
V
Y----KDY-SS
R
R
I
L
T
L
S
LEQGDSIETASS------W------------P
I
E
I
R
N
T
I
G
R
R
L
I
R
A
L
G
Q
E
M
F
F
L
K
--
R
FHCDPHPG---N
F
A
FR-Q-DG
S
V
I
I
Y
DYGS
V
K
T
L
S
N
E
I
V
Y
S
F
K
R
L
V
N
A
ARHE--------
D
I
D
L
I
E
T
E
L
L
--
E
L
H
S
L
-
A
-EK----GK
F
--
P
S
D
L
Y
K
L
W
I
E
V
L
L
R
-PLTT--
T
Y
DFAENSSQHD
G
M
L
L
V
K
KSLKY---WDVFKPSP
D
T
L
M
-
V
NRTISG
H
Y
W
N
-
L
I
H
L
K
V
HD
N
L
N
D
L
F
K
E
LVPLSN------
1
PsiBlast_PDB
79.77
26%
11
- C2 -
-
4PED
-
COQ8A_HUMAN
A:
[8-381]
----------------------------------------------------------------------------------
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
G
Q
----------
M
L
S
I
Q
D
D
A
-
F
I
N
P
H
L
A
K
I
F
E
R
V
R
Q
S
A
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-
D
-
L
G
P
N
-
W
R
D
K
L
E
Y
F
E
E
--------
R
P
F
A
A
A
S
I
G
Q
V
H
L
A
R
M
-------
K
----
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
N
------
L
M
A
V
L
N
M
S
N
M
L
P
E
G
L
F
P
--
E
HL
I
D
V
L
R
R
E
L
A
L
E
C
D
Y
Q
R
-------
E
A
A
C
A
R
K
F
R
D
L
-
L
K
G
-
H
---------
P
F
F
Y
V
P
E
I
V
----
D
E
L
-
C
S
P
H
V
L
T
T
E
L
V
S
G
F
P
L
D
Q
A
E
G
------
L
------------
S
Q
E
I
R
N
E
I
C
Y
N
I
L
V
L
C
L
R
E
L
F
E
F
H
--
F
M
Q
T
D
P
N
W
S
---
N
F
F
Y
D
P
Q
-
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
--------
D
R
E
T
V
R
A
K
S
I
--
E
M
K
F
L
T
G
-
Y
E
----
V
K
V
--
M
E
D
A
H
L
D
A
I
L
I
L
G
E
-
A
F
A
S
DE
P
F
D
F
G
T
Q
S
T
T
E
K
I
H
N
L
I
P
V
M
L
R
H
---
R
L
V
-
P
P
P
E
E
T
Y
S
-
L
H
R
K
M
G
G
S
F
L
I
-
C
S
K
L
K
A
R
F
P
C
K
A
M
F
E
E
------------
2
PsiBlast_PDB
77.85
26%
11
- C2 -
-
5I35
1
COQ8A_HUMAN
A:
[8-381]
----------------------------------------------------------------------------------
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
G
Q
----------
M
L
S
I
Q
D
D
A
-
F
I
N
P
H
L
A
K
I
F
E
R
V
R
Q
S
A
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-
D
-
L
G
P
N
-
W
R
D
K
L
E
Y
F
E
E
--------
R
P
F
A
A
A
S
I
G
Q
V
H
L
A
R
M
-------
K
----
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
N
------
L
M
A
V
L
N
M
S
N
M
L
P
E
G
L
F
P
--
E
H
L
I
D
V
L
R
R
E
L
A
L
E
C
D
Y
Q
R
-------
E
A
A
C
A
R
K
F
R
D
L
-
L
K
G
-
H
---------
P
F
F
Y
V
P
E
I
V
----
D
E
L
-
C
S
P
H
V
L
T
T
E
L
V
S
G
F
P
L
D
Q
A
E
G
------
L
------------
S
Q
E
I
R
N
E
I
C
Y
N
I
L
V
L
C
L
R
E
L
F
E
F
H
--
F
M
Q
T
D
P
N
W
S
---
N
F
F
Y
D
P
Q
-
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
--------
D
R
E
T
V
R
A
K
S
I
--
E
M
K
F
L
T
G
-
Y
E
----
V
K
V
--
M
E
D
A
H
L
D
A
I
L
I
L
G
E
-
A
F
A
S
DE
P
F
D
F
G
T
Q
S
T
T
E
K
I
H
N
L
I
P
V
M
L
R
H
---
R
L
V
-
P
P
P
E
E
T
Y
S
-
L
H
K
K
M
G
G
S
F
L
I
-
C
S
K
L
K
A
R
F
P
C
K
A
M
F
E
E
------------
31
HHSearch
76.09
24%
5
- C2 -
-
4PED
-
COQ8A_HUMAN
A:
[4-387]
---------------------------------------------------------------------------
A
N
---
A
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
G
Q
----------
M
L
S
I
Q
D
D
A
F
I
-
N
P
H
L
A
K
I
F
E
R
V
R
Q
S
A
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-
D
-
L
G
P
N
-
W
R
D
K
L
E
Y
F
E
E
--------
R
P
F
A
A
A
S
I
G
Q
V
H
L
A
R
M
-------
K
----
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
P
-
E
G
L
F
P
E
H
L
I
D
--
V
-----
L
R
R
E
L
A
L
E
C
D
Y
Q
R
-------
E
A
A
C
A
R
K
F
R
D
L
L
K
-
G
-
H
---------
P
F
F
Y
V
P
E
I
V
----
D
E
L
-
C
S
P
H
V
L
T
T
E
L
V
S
G
F
P
L
D
Q
A
E
G
------
L
------------
S
Q
E
I
R
N
E
I
C
Y
N
I
L
V
L
C
L
R
E
L
F
E
F
H
--
F
M
Q
T
D
P
N
W
S
---
N
F
F
Y
D
-
P
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
--------
D
R
E
T
V
R
-
A
K
S
--
I
E
M
K
F
-
L
T
G
Y
----
E
V
K
V
M
E
D
A
-
H
L
D
A
I
L
I
L
G
E
-
A
F
A
S
DE
P
F
D
F
G
T
Q
S
T
T
E
K
I
H
N
L
-
I
P
-
V
M
L
---
R
H
R
L
V
P
P
P
E
E
T
Y
S
L
H
R
K
M
G
G
S
F
L
I
-
C
S
K
L
K
A
R
F
P
C
K
A
M
F
E
E
A
Y
S
N
Y
C
------
58
HHSearch
47.11
12%
-85
- C2 -
-
5T18
1
A:
[14-157]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-------
R
----
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
----------------------------------------------
E
D
E
F
I
E
-------
E
A
K
V
M
M
N
L
S
-----
H
-
E
---------
K
L
V
Q
L
Y
G
V
C
----
T
K
--
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E-----
F
------------
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
-
M
E
Y
L
E
S
K
Q
--
F
L
H
R
D
L
A
A
R
---
N
C
L
V
N
-
D
-
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
45.21
14%
-58
- C2 -
-
1QCF
1
HCK_HUMAN
A:
[121-336]
---------------------------------------------------------------------------
D
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
----------
T
F
S
T
L
Q
E
L
-
V
-
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
-
D
-
A
W
E
I
-
P
R
E
S
L
K
L
E
----------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
----
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
----------------------------------------------
V
E
A
F
L
A
-------
E
A
N
V
M
K
T
L
Q
-----
H
-
D
---------
K
L
V
K
L
H
A
V
V
------
T
-
K
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
------------
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
-
M
A
F
I
E
Q
R
N
--
Y
I
H
R
D
L
R
A
A
---
N
I
L
V
S
-
A
-
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
43.58
13%
-58
- C2 -
-
5TE0
4
AAK1_HUMAN
A:
[25-178]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
-------
S
----
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
----
L
-----------------------------------------
Q
V
C
K
R
-------
E
I
Q
I
M
R
D
L
S
G
----
H
-
K
---------
N
I
V
G
Y
I
D
S
S
----
I
N
N
V
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
QTG
F
------------
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
-
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
---
N
I
L
L
H
-
D
-
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
43.12
30%
-83
- C5 -
-
4GFQ
-
RRF_BACAN
A:
[92-140]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
Y
D
K
T
S
I
G
D
I
E
K
A
I
L
K
A
DLG
L
N
P
----
S
N
D
G
T
V
I
R
I
A
F
P
A
L
T
E
E
R
R
R
D
L
V
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
41.99
17%
-49
- C3 -
-
4H2Q
7
?
A:
[10-379]
-------------------------
K
T
R
R
A
E
V
A
G
G
---
G
F
A
G
L
T
A
A
I
A
L
K
Q
N
G
W
D
V
R
L
H
E
K
S
S
E
L
R
A
F
G
A
G
I
Y
L
W
H
N
---
G
L
R
V
L
E
G
L
G
A
L
D
D
V
L
Q
G
S
H
T
----------
P
P
T
Y
E
T
W
M
-
H
-
N
K
S
V
S
K
E
------
T
F
N
G
L
P
W
R
I
M
T
---------
R
S
H
-
L
H
D
A
L
V
N
R
A
R
--------
A
L
G
V
D
I
S
V
N
S
E
A
V
A
A
D
-------
P
----
V
G
R
L
T
L
Q
T
G
E
V
L
E
A
D
L
I
V
G
A
D
G
V
G
S
K
V
R
D
S
I
-
G
F
K
Q
D
R
W
V
S
K
D
G
L
I
R
--
L
-----
I
V
P
R
M
K
K
E
L
G
H
G
E
-------
W
D
N
T
I
D
M
W
N
F
W
P
R
V
Q
------------
R
I
L
Y
S
P
C
N
----
E
N
------
E
L
Y
L
G
L
M
A
P
A
A
D
P
R
G
S
S
------
V
------------
P
I
D
----------
L
E
V
W
V
E
M
F
------
P
F
L
E
P
C
L
I
---
E
A
A
K
L
-
K
-
T
A
R
Y
D
K
Y
E
T
T
K
L
D
S
W
T
R
G
K
V
A
L
V
G
D
A
A
H
A
M
C
P
A
--------
L
A
Q
G
A
G
C
A
M
V
--
N
A
F
S
L
-
S
-
Q
D
----
L
E
E
--
G
S
S
V
E
D
A
L
V
A
W
E
T
R
-
I
R
P
I
--
T
D
R
C
Q
A
L
S
G
D
Y
A
A
N
----
R
S
L
S
K
---
G
N
M
F
--
T
P
A
A
L
E
-
A
A
R
---------------
Y
D
P
L
R
R
V
Y
S
W
P
Q
----------
23
Fugue
41.67
16%
-47
- C3 -
-
4GF7
8
?
A:
[10-379]
-------------------------
K
T
R
R
A
E
V
A
G
G
---
G
F
A
G
L
T
A
A
I
A
L
K
Q
N
G
W
D
V
R
L
H
E
K
S
S
E
L
R
A
F
G
A
G
I
Y
L
W
H
N
---
G
L
R
V
L
E
G
L
G
A
L
D
D
V
L
Q
G
S
H
T
----------
P
P
T
Y
E
T
W
M
-
H
-
N
K
S
V
S
K
E
------
T
F
N
G
L
P
W
R
I
M
T
---------
R
S
H
-
L
H
D
A
L
V
N
R
A
R
--------
A
L
G
V
D
I
S
V
N
S
E
A
V
A
A
D
-------
P
----
V
G
R
L
T
L
Q
T
G
E
V
L
E
A
D
L
I
V
G
A
D
G
V
G
S
K
V
R
D
S
I
-
G
F
K
Q
D
R
W
V
S
K
D
G
L
I
R
--
L
-----
I
V
P
R
M
K
K
E
L
G
H
G
E
-------
W
D
N
T
I
D
M
W
N
F
W
P
R
-----------------
V
Q
R
I
L
----
Y
S
P
-
C
N
E
N
E
L
Y
L
G
L
M
A
P
A
A
D
P
R
G
S
S
------
V
------------
P
I
D
----------
L
E
V
W
V
E
M
F
------
P
F
L
E
P
C
L
I
---
E
A
A
K
L
-
K
-
T
A
R
Y
D
K
Y
E
T
T
K
L
D
S
W
T
R
G
K
V
A
L
V
G
D
A
A
H
A
M
C
P
A
--------
L
A
Q
G
A
G
C
A
M
V
--
N
A
F
S
L
-
S
-
Q
D
----
L
E
E
--
G
S
S
V
E
D
A
L
V
A
W
E
T
R
-
I
R
P
I
--
T
D
R
C
Q
A
L
S
G
D
Y
A
A
N
----
R
S
L
S
K
---
G
N
M
F
--
T
P
A
A
L
E
-
A
A
R
---------------
Y
D
P
L
R
R
V
Y
S
W
P
Q
----------
39
HHSearch
41.14
13%
-55
- C2 -
-
1AD5
1
HCK_HUMAN
B:
[116-329]
----------------------------------------------------------------------------
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
----------
T
F
S
T
L
Q
E
L
-
V
-
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
-
D
-
A
W
E
I
-
P
R
E
S
L
K
L
E
----------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
----
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
----------------------------------------------
V
E
A
F
L
A
-------
E
A
N
V
M
K
T
L
Q
-----
H
-
D
---------
K
L
V
K
L
H
A
V
V
----
T
---
K
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
SDEGSK
Q
------------
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
-
M
A
F
I
E
Q
R
N
--
Y
I
H
R
D
L
R
A
A
---
N
I
L
V
S
-
A
-
S
L
V
C
K
I
A
D
F
G
L
A
R
V
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
40.23
18%
-16
- C2 -
-
3COM
-
STK4_HUMAN
A:
[29-176]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
D
V
--
L
--------
E
K
L
G
----
G
S
V
Y
K
A
I
H
-------
K
E---
T
G
Q
I
V
A
I
K
Q
V
P
V
E
S
D
L
-----------------------------------------------
Q
E
I
I
K
-------
E
I
S
I
M
Q
Q
C
D
-----
S
-
P
---------
H
V
V
K
Y
Y
G
S
Y
----
F
K
--
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
N
K
T
-
L
------------
T
E
D
E
I
A
T
I
L
Q
S
T
L
K
G
-
L
E
Y
L
H
F
M
R
--
K
I
H
R
D
I
K
A
G
---
N
I
L
L
N
-
T
-
E
G
H
A
K
L
A
D
F
G
V
A
G
Q
L
T
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
39.56
13%
-59
- C2 -
-
4LQS
1
CBK1_YEAST
A:
[108-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
-------
K
D---
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
K
----------------------------------------------------------------
S
D
-----
S
-
P
---------
W
V
V
S
L
Y
Y
S
F
----
Q
D
--
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
WQL--
F
------------
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
-
I
E
T
I
H
K
L
G
--
F
I
H
R
A
I
K
P
D
---
N
I
L
I
D
-
I
-
R
G
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
----------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
39.00
14%
-8
- C2 -
-
2F57
1
B:
[17-194]
----------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
S
M
S
R
V
S
H
E
Q
F
R
A
A
L
Q
L
-
V
-
V
S
P
G
D
P
R
E
Y
L
A
N
F
----------
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
-------
K
H---
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
---------------------------------------
E
------
L
L
F
N
-------
E
V
V
I
M
R
D
Y
H
-----
H
-
D
---------
N
V
V
D
M
Y
S
S
Y
----
L
-
V
-
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---
M
------------
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
-
L
S
Y
L
H
N
Q
G
--
V
I
H
R
D
I
K
S
D
---
S
I
L
L
T
-
S
-
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
37.31
15%
-11
- C2 -
-
4ASE
1
A:
[70-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
GIDKT-
A
----
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
---
E
-----------------------------------------
H
R
A
L
M
S
-------
E
L
K
I
L
I
H
I
G
-----
H
H
L
---------
N
V
V
N
L
L
G
A
C
----
T
K
P
-
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-----
K
R
NEFVPYYKDFL
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
-
M
E
F
L
A
S
R
K
--
C
I
H
R
D
L
A
A
R
---
N
I
L
L
S
-
E
-
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
36.91
18%
-12
* C2 *
-
4KS7
2
A:
[28-172]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--------
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
-------
K
H---
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
Q
Q
R
---------------------------------------------
R
E
L
L
F
N
-------
E
V
V
I
M
R
D
Y
Q
-----
H
-
F
---------
N
V
V
E
M
Y
K
S
Y
----
L
V
--
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
V
R
---
L
------------
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
-
L
A
Y
L
H
A
Q
G
--
V
I
H
R
D
I
K
S
D
---
S
I
L
L
T
-
L
-
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
36.70
16%
13
- C1 -
-
3J9E
-
?
D:
[2-521]
GKVIRSLNRFGKKVGNALTSNTAKK
I
Y
S
T
I
G
K
A
A
E
R
F
A
E
S
E
I
G
S
A
A
I
D
G
L
-
V
Q
G
S
V
H
S
I
I
T
G
E
S
Y
G
E
S
V
K
Q
A
V
L
L
N
V
LGS
G
E
E
I
P
D
P
L
S
P
G
E
R
G
I
Q
A
K
L
K
ELEDEQRNEL
V
R
L
K
Y
N
D
K
-
I
-
K
E
K
F
G
K
E
L
E
E
V
Y
N
F
M
N
G
E
A
N
A
E
I
E
D
E
K
Q
F
-
D
I
L
N
K
A
-
V
T
S
Y
N
K
I
L
T
E
--------
E
D
L
Q
M
R
R
L
A
T
A
L
Q
K
E
I
-------
G
ER--
T
H
A
E
T
V
M
V
K
E
Y
R
D
K
I
D
A
L
K
N
A
I
E
V
E
R
D
G
M
Q
E
E
A
I
Q
E
I
A
G
M
T
A
D
V
L
E
A
AS
E
-----
E
V
P
L
I
G
A
G
M
A
T
A
V
ATGRAIE
G
A
Y
K
L
K
K
V
I
N
A
L
S
G
I
-
D
LTHLRTPKI
E
P
S
V
V
S
T
I
L
EYRA
K
E
I
-
P
D
N
A
L
A
V
S
V
L
S
K
N
R
A
I
Q
E
N
H
K
------
E
------------
L
M
H
I
K
N
E
I
L
P
R
F
K
K
A
M
D
E
E
K
E
I
C
G
--
I
E
D
K
V
I
H
P
K
VMM
K
F
K
I
P
-
R
-
A
Q
Q
P
Q
I
H
V
Y
S
A
--
P
W
D
S
D
D
V
F
F
F
H
C
I
S
H
H
H
A
N
E
SFFLGFDL
S
I
D
L
V
H
Y
E
D
L
TA
H
W
H
A
L
-
G
-
A
A
QTAA
G
R
T
--
L
T
E
A
Y
R
E
F
L
N
L
A
I
S
N
A
F
G
T
--
Q
M
H
T
R
R
L
V
R
S
K
T
V
H
P
I
Y
L
G
S
L
H
Y
DIS
F
S
D
L
R
G
N
A
Q
R
I
V
-
Y
D
D
E
L
Q
M
H
I
L
R
G
P
I
H
F
Q
R
R
A
I
L
G
A
L
K
F
G
C
K
V
L
G
D
RLDVPL
35
HHSearch
36.15
16%
24
- C2 -
-
4AW2
4
MRCKA_RAT
A:
[12-245]
----------------------------------------------------------------------------------------------
F
I
L
D
G
P
----------
A
Q
T
N
G
Q
C
F
-
S
-
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
-
W
A
K
P
-
F
T
S
K
V
K
Q
M
R
L
HREDFEIL
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
-------
K
N---
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
-----------------------------------------
T
A
C
F
R
E
-------
E
R
D
V
L
V
N
G
------
D
-
S
---------
K
W
I
T
T
L
H
Y
A
----
F
Q
D
-
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
EDR-
L
------------
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
-
I
D
S
V
H
Q
L
H
--
Y
V
H
R
D
I
K
P
D
---
N
I
L
M
D
-
M
-
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
35.55
14%
-16
- C2 -
-
3BKB
6
A:
[120-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-------
R
A---
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
--------------------------------------------
K
A
K
F
L
Q
-------
E
A
R
I
L
K
Q
Y
S
-----
H
-
P
---------
N
I
V
R
L
I
G
V
C
----
T
-
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
EGAR-
L
------------
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
-
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
---
N
C
L
V
T
-
E
-
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
35.18
14%
-13
- C2 -
-
3CBL
3
A:
[120-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-------
R
A---
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
--------------------------------------------
K
A
K
F
L
Q
-------
E
A
R
I
L
K
Q
Y
S
-----
H
-
P
---------
N
I
V
R
L
I
G
V
C
----
T
-
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
EGAR-
L
------------
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
-
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
---
N
C
L
V
T
-
E
-
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
34.91
16%
-28
- C2 -
-
1VZO
-
KS6A5_HUMAN
A:
[60-214]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
T
G
A
Y
G
K
V
F
L
V
R
K
-------
I
SGHD
T
G
K
L
Y
A
M
K
V
L
K
K
A
T
I
V
Q
K
A
K
-----------------------------------------
T
T
E
H
T
R
T
-------
E
R
Q
V
L
E
H
I
R
-----
Q
-
S
---------
P
F
L
V
T
L
H
Y
A
----
F
Q
T
-
E
T
K
L
H
L
I
L
D
Y
I
N
G
G
E
L
F
T
H
L
S
Q
R
ER--
F
------------
T
E
H
E
V
Q
I
Y
V
G
E
I
V
L
A
-
L
E
H
L
H
K
L
G
--
I
I
Y
R
D
I
K
L
E
---
N
I
L
L
D
-
S
-
N
G
H
V
V
L
T
D
F
G
L
S
K
E
F
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------