@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLF5: (2017-11-02 )
MFANISISEFDPELAQAIASEDERQEAHIELIASENYCSPAVMEAQGSKLTNKYAEGYPGKRYYGGCEFVDVIEQMAIDRAKELFGADYANVQPHAGSQANSAVYLALLNPGDTVLGMSLAHGGHLTHGAKVSFSGKTYNAVQYGLNAETGEIDYEEVERLALEHKPRMIVAGFSAYSRVVDWQRFRDIADKVGAYLFVDMAHVAGLVAAGVYPNPVQIADVTTTTTHKTLRGPRSGLILAKANEEIEKKLQSAVFPGNQGGPLMHAIAAKAICFKVAMSDDFKAYQKQVVKNAQAMAEVFIARGYDVVSGGTDNHLFLLSLIKQDVTGKDADAWLGAAHITVNKNSVPNDPRSPFVTSGIRIGTPAVTTRGFGETEVRELAGWIADVIDSKGDEKVIADVKAKVEAVCAKFPVYAK
Atome Classification :
(62 SA)
---------.........10........20........30........40........50........60........70........80.......----.----90---.........100.......110.......120.......-----130----.-----.......140....--...150.......160.......170.......180.........190.......200.......210.......220.......230.......240-----...-...------.-------------..--250.......260.......270.......280.......290.......300..-.....310.......320.......330.......340.......350.......360.......370.......380.......----------------------390---------------------.....------------------------....400.......410.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------MFANI
S
I
S
EF
D
P
E
L
A
Q
A
I
AS
E
D
E
RQE
A
H
I
E
L
I
ASENYCS
P
A
V
M
EAQ
G
S
K
L
T
N
K
YAEGYPGKRYYGG
C
E
F
V
D
V
I
E
Q
M
A
I
D
R
A
K
E
L
FGAD----Y----A----NVQPHAGSQAN
S
A
V
Y
L
A
L
LNPGD
T
V
L
G
M
S
LAHGGHLTHG-----
A
K
-----
V
-----
S
FSGK
T
Y
N
A
V
Q
YGL--NAETGEI
D
Y
E
E
V
E
R
L
A
L
EHKP
R
M
I
V
A
G
F
S
A
Y
S
R
V
--
V
D
W
Q
R
F
R
D
I
A
D
KV
G
A
Y
L
F
V
D
M
A
H
V
A
G
L
V
A
AGVYPN
P
V
Q
I
A
D
V
T
TTTTHKTLRGPRS
G
L
I
L
-------AKA-
N
E
E
------
I
-------------
E
K
--
K
L
Q
S
AVFPGNQG
G
P
L
M
H
A
I
A
A
K
A
I
C
F
K
V
AMSD
D
F
K
A
Y
Q
K
Q
V
V
K
N
A
Q
A
M
A
E
V
F
I
AR-G
Y
D
VVSGGTD
N
H
L
F
L
L
S
L
I
K
Q
DVTGKDAD
A
W
L
G
A
A
H
I
T
VNKNSVPNDPRSPFVTS
G
I
R
IGTPAVTTRGF
G
E
T
E
V
R
E
L
A
G
W
I
A
D
V
I----------------------D-----------------------SKGD
E
------------------------
K
V
I
A
D
V
K
A
K
V
E
A
V
C
AKFPVYAK
1
PsiBlast_PDB
94.75
99%
-97
- C1 -
-
5VMB
-
?
A:
[9-425]
---------
M
F
A
N
I
S
I
S
E
F
D
P
E
L
A
Q
A
I
A
S
E
D
E
R
Q
E
A
H
I
E
L
I
A
S
E
N
Y
C
S
P
A
V
M
E
A
Q
G
S
K
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
F
V
D
V
I
E
Q
M
A
I
D
R
A
K
E
L
F
G
A
D
----
Y
----
A
----
N
V
Q
P
H
A
G
S
Q
A
N
S
A
V
Y
L
A
L
L
N
P
G
D
T
V
L
G
M
S
----------------------------------
Y
N
A
V
Q
Y
G
L
--
N
A
E
T
G
E
I
D
Y
E
E
V
E
R
L
A
L
E
H
K
P
R
M
I
V
A
G
F
S
A
Y
S
R
V
--
V
D
W
Q
R
F
R
D
I
A
D
K
V
G
A
Y
L
F
V
D
M
A
H
V
A
G
L
V
A
A
G
V
Y
P
N
P
V
Q
I
A
D
V
T
T
T
T
T
H
K
T
L
R
G
P
R
S
G
L
I
L
-------
A
K
A
-
N
E
E
------
I
-------------
E
K
--
K
L
Q
S
A
V
F
P
G
N
Q
G
G
P
L
M
H
A
I
A
A
K
A
I
C
F
K
E
A
M
S
D
D
F
K
A
Y
Q
Q
Q
V
V
K
N
A
Q
A
M
A
E
V
F
I
A
R
-
G
Y
D
V
V
S
G
G
T
D
N
H
L
F
L
L
S
L
I
K
Q
D
V
T
G
K
D
A
D
A
W
L
G
A
A
H
I
T
V
N
K
N
S
V
P
N
D
P
R
S
P
F
V
T
S
G
I
R
I
G
T
P
A
V
T
T
R
G
F
G
E
A
E
V
R
E
L
A
G
W
I
A
D
V
I
----------------------
D
-----------------------
S
K
G
D
E
------------------------
K
V
I
A
D
V
K
A
K
V
E
A
V
C
A
K
F
P
V
Y
A
K
34
PsiBlast_CBE
85.82
62%
-91
- C1 -
-
4OT8
4
?
D:
[15-422]
-------------
S
T
I
A
N
V
D
P
E
I
F
A
A
I
E
Q
E
N
R
R
Q
E
D
H
I
E
L
I
A
S
E
N
Y
T
S
P
A
V
M
A
A
Q
G
S
Q
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
V
V
E
Q
L
A
I
D
R
V
K
Q
L
F
G
A
E
----
A
----
A
----
N
V
Q
P
N
S
G
S
Q
A
N
Q
G
V
F
F
A
M
L
K
P
G
D
T
I
M
G
M
S
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
M
S
G
K
W
F
N
V
V
S
Y
G
L
--
N
-
E
N
E
D
I
D
Y
D
A
A
E
K
L
A
N
E
H
K
P
K
L
I
V
A
G
A
S
A
F
A
L
K
--
I
D
F
E
R
L
A
K
I
A
K
S
V
G
A
Y
L
M
V
D
M
A
H
Y
A
G
L
I
A
A
G
V
Y
P
N
P
V
P
H
A
D
F
V
T
T
T
T
H
K
S
L
R
G
P
R
G
G
V
I
L
-------
M
K
A
---
E
------
Y
-------------
E
K
--
P
I
N
S
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
K
E
A
L
S
P
E
F
K
E
Y
Q
Q
K
V
V
E
N
A
R
V
L
A
E
T
L
V
K
R
-
G
L
R
I
V
S
G
R
T
E
S
H
V
M
L
V
D
L
R
A
K
H
I
T
G
K
A
A
E
A
A
L
G
A
A
H
I
T
V
N
K
N
A
I
P
N
D
P
E
K
P
F
V
T
S
G
I
R
L
G
S
P
A
M
T
T
R
G
F
G
P
A
E
A
E
Q
V
G
N
L
I
A
D
V
L
----------------------
E
-----------------------
N
P
E
D
A
------------------------
A
T
I
E
R
V
R
A
Q
V
A
E
L
T
K
R
F
P
V
Y
--
33
PsiBlast_CBE
85.30
62%
-90
- C1 -
-
4OTL
5
?
B:
[15-422]
-------------
S
T
I
A
N
V
D
P
E
I
F
A
A
I
E
Q
E
N
R
R
Q
E
D
H
I
E
L
I
A
S
E
N
Y
T
S
P
A
V
M
A
A
Q
G
S
Q
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
V
V
E
Q
L
A
I
D
R
V
K
Q
L
F
G
A
E
----
A
----
A
----
N
V
Q
P
N
S
G
S
Q
A
N
Q
G
V
F
F
A
M
L
K
P
G
D
T
I
M
G
M
S
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
M
S
G
K
W
F
N
V
V
S
Y
G
L
--
N
-
E
N
E
D
I
D
Y
D
A
A
E
K
L
A
N
E
H
K
P
K
L
I
V
A
G
A
S
A
F
A
L
K
--
I
D
F
E
R
L
A
K
I
A
K
S
V
G
A
Y
L
M
V
D
M
A
H
Y
A
G
L
I
A
A
G
V
Y
P
N
P
V
P
H
A
D
F
V
T
T
T
T
H
K
S
L
R
G
P
R
G
G
V
I
L
-------
M
K
A
---
E
------
Y
-------------
E
K
--
P
I
N
S
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
K
E
A
L
S
P
E
F
K
E
Y
Q
Q
K
V
V
E
N
A
R
V
L
A
E
T
L
V
K
R
-
G
L
R
I
V
S
G
R
T
E
S
H
V
M
L
V
D
L
R
A
K
H
I
T
G
K
A
A
E
A
A
L
G
A
A
H
I
T
V
N
K
N
A
I
P
N
D
P
E
K
P
F
V
T
S
G
I
R
L
G
S
P
A
M
T
T
R
G
F
G
P
A
E
A
E
Q
V
G
N
L
I
A
D
V
L
----------------------
E
-----------------------
N
P
E
D
A
------------------------
A
T
I
E
R
V
R
A
Q
V
A
E
L
T
K
R
F
P
V
Y
--
36
PsiBlast_CBE
85.00
62%
-88
- C1 -
-
4OT8
4
?
B:
[13-422]
-----------
A
Q
S
T
I
A
N
V
D
P
E
I
F
A
A
I
E
Q
E
N
R
R
Q
E
D
H
I
E
L
I
A
S
E
N
Y
T
S
P
A
V
M
A
A
Q
G
S
Q
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
V
V
E
Q
L
A
I
D
R
V
K
Q
L
F
G
A
E
----
A
----
A
----
N
V
Q
P
N
S
G
S
Q
A
N
Q
G
V
F
F
A
M
L
K
P
G
D
T
I
M
G
M
S
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
M
S
G
K
W
F
N
V
V
S
Y
G
L
--
N
-
E
N
E
D
I
D
Y
D
A
A
E
K
L
A
N
E
H
K
P
K
L
I
V
A
G
A
S
A
F
A
L
K
--
I
D
F
E
R
L
A
K
I
A
K
S
V
G
A
Y
L
M
V
D
M
A
H
Y
A
G
L
I
A
A
G
V
Y
P
N
P
V
P
H
A
D
F
V
T
T
T
T
H
K
S
L
R
G
P
R
G
G
V
I
L
-------
M
K
A
---
E
------
Y
-------------
E
K
--
P
I
N
S
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
K
E
A
L
S
P
E
F
K
E
Y
Q
Q
K
V
V
E
N
A
R
V
L
A
E
T
L
V
K
R
-
G
L
R
I
V
S
G
R
T
E
S
H
V
M
L
V
D
L
R
A
K
H
I
T
G
K
A
A
E
A
A
L
G
A
A
H
I
T
V
N
K
N
A
I
P
N
D
P
E
K
P
F
V
T
S
G
I
R
L
G
S
P
A
M
T
T
R
G
F
G
P
A
E
A
E
Q
V
G
N
L
I
A
D
V
L
----------------------
E
-----------------------
N
P
E
D
A
------------------------
A
T
I
E
R
V
R
A
Q
V
A
E
L
T
K
R
F
P
V
Y
--
9
PsiBlast_PDB
84.62
62%
-90
- C1 -
-
4OTL
4
?
A:
[15-422]
-------------
S
T
I
A
N
V
D
P
E
I
F
A
A
I
E
Q
E
N
R
R
Q
E
D
H
I
E
L
I
A
S
E
N
Y
T
S
P
A
V
M
A
A
Q
G
S
Q
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
V
V
E
Q
L
A
I
D
R
V
K
Q
L
F
G
A
E
----
A
----
A
----
N
V
Q
P
N
S
G
S
Q
A
N
Q
G
V
F
F
A
M
L
K
P
G
D
T
I
M
G
M
S
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
M
S
G
K
W
F
N
V
V
S
Y
G
L
--
N
-
E
N
E
D
I
D
Y
D
A
A
E
K
L
A
N
E
H
K
P
K
L
I
V
A
G
A
S
A
F
A
L
K
--
I
D
F
E
R
L
A
K
I
A
K
S
V
G
A
Y
L
M
V
D
M
A
H
Y
A
G
L
I
A
A
G
V
Y
P
N
P
V
P
H
A
D
F
V
T
T
T
T
H
K
S
L
R
G
P
R
G
G
V
I
L
-------
M
K
A
---
E
------
Y
-------------
E
K
--
P
I
N
S
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
K
E
A
L
S
P
E
F
K
E
Y
Q
Q
K
V
V
E
N
A
R
V
L
A
E
T
L
V
K
R
-
G
L
R
I
V
S
G
R
T
E
S
H
V
M
L
V
D
L
R
A
K
H
I
T
G
K
A
A
E
A
A
L
G
A
A
H
I
T
V
N
K
N
A
I
P
N
D
P
E
K
P
F
V
T
S
G
I
R
L
G
S
P
A
M
T
T
R
G
F
G
P
A
E
A
E
Q
V
G
N
L
I
A
D
V
L
----------------------
E
-----------------------
N
P
E
D
A
------------------------
A
T
I
E
R
V
R
A
Q
V
A
E
L
T
K
R
F
P
V
Y
--
62
PsiBlast_CBE
84.29
59%
-93
- C1 -
-
2VMT
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
53
PsiBlast_CBE
84.27
59%
-94
- C1 -
-
2VMP
4
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
59
PsiBlast_CBE
84.07
59%
-92
- C1 -
-
2W7J
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
48
PsiBlast_CBE
83.88
59%
-93
- C1 -
-
2VGT
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
52
PsiBlast_CBE
83.63
59%
-93
- C1 -
-
2VMQ
5
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
16
PsiBlast_PDB
83.59
59%
-93
- C1 -
-
2VI8
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
63
PsiBlast_CBE
83.53
59%
-93
- C1 -
-
2VMS
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
45
PsiBlast_CBE
83.51
59%
-90
- C1 -
-
2VGW
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
18
PsiBlast_PDB
83.51
59%
-91
- C1 -
-
2VIA
4
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
64
PsiBlast_CBE
83.38
59%
-93
- C1 -
-
2VMR
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
49
PsiBlast_CBE
83.38
59%
-91
- C1 -
-
2VGS
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
56
PsiBlast_CBE
83.35
59%
-93
- C1 -
-
2W7M
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
54
PsiBlast_CBE
83.35
59%
-93
- C1 -
-
2VMO
4
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
47
PsiBlast_CBE
83.31
59%
-92
- C1 -
-
2VGU
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
66
PsiBlast_CBE
83.28
59%
-92
- C1 -
-
2VMY
7
?
B:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------