@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLF5: (2017-11-02 )
MFANISISEFDPELAQAIASEDERQEAHIELIASENYCSPAVMEAQGSKLTNKYAEGYPGKRYYGGCEFVDVIEQMAIDRAKELFGADYANVQPHAGSQANSAVYLALLNPGDTVLGMSLAHGGHLTHGAKVSFSGKTYNAVQYGLNAETGEIDYEEVERLALEHKPRMIVAGFSAYSRVVDWQRFRDIADKVGAYLFVDMAHVAGLVAAGVYPNPVQIADVTTTTTHKTLRGPRSGLILAKANEEIEKKLQSAVFPGNQGGPLMHAIAAKAICFKVAMSDDFKAYQKQVVKNAQAMAEVFIARGYDVVSGGTDNHLFLLSLIKQDVTGKDADAWLGAAHITVNKNSVPNDPRSPFVTSGIRIGTPAVTTRGFGETEVRELAGWIADVIDSKGDEKVIADVKAKVEAVCAKFPVYAK
Atome Classification :
(62 SA)
---------.........10........20........30........40........50........60........70........80.......----.----90---.........100.......110.......120.......-----130----.-----.......140....--...150.......160.......170.......180.........190.......200.......210.......220.......230.......240-----...-...------.-------------..--250.......260.......270.......280.......290.......300..-.....310.......320.......330.......340.......350.......360.......370.......380.......----------------------390---------------------.....------------------------....400.......410.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------MFANI
S
I
S
EF
D
P
E
L
A
Q
A
I
AS
E
D
E
RQE
A
H
I
E
L
I
ASENYCS
P
A
V
M
EAQ
G
S
K
L
T
N
K
YAEGYPGKRYYGG
C
E
F
V
D
V
I
E
Q
M
A
I
D
R
A
K
E
L
FGAD----Y----A----NVQPHAGSQAN
S
A
V
Y
L
A
L
LNPGD
T
V
L
G
M
S
LAHGGHLTHG-----
A
K
-----
V
-----
S
FSGK
T
Y
N
A
V
Q
YGL--NAETGEI
D
Y
E
E
V
E
R
L
A
L
EHKP
R
M
I
V
A
G
F
S
A
Y
S
R
V
--
V
D
W
Q
R
F
R
D
I
A
D
KV
G
A
Y
L
F
V
D
M
A
H
V
A
G
L
V
A
AGVYPN
P
V
Q
I
A
D
V
T
TTTTHKTLRGPRS
G
L
I
L
-------AKA-
N
E
E
------
I
-------------
E
K
--
K
L
Q
S
AVFPGNQG
G
P
L
M
H
A
I
A
A
K
A
I
C
F
K
V
AMSD
D
F
K
A
Y
Q
K
Q
V
V
K
N
A
Q
A
M
A
E
V
F
I
AR-G
Y
D
VVSGGTD
N
H
L
F
L
L
S
L
I
K
Q
DVTGKDAD
A
W
L
G
A
A
H
I
T
VNKNSVPNDPRSPFVTS
G
I
R
IGTPAVTTRGF
G
E
T
E
V
R
E
L
A
G
W
I
A
D
V
I----------------------D-----------------------SKGD
E
------------------------
K
V
I
A
D
V
K
A
K
V
E
A
V
C
AKFPVYAK
1
PsiBlast_PDB
94.75
99%
-97
- C1 -
-
5VMB
-
?
A:
[9-425]
---------
M
F
A
N
I
S
I
S
E
F
D
P
E
L
A
Q
A
I
A
S
E
D
E
R
Q
E
A
H
I
E
L
I
A
S
E
N
Y
C
S
P
A
V
M
E
A
Q
G
S
K
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
F
V
D
V
I
E
Q
M
A
I
D
R
A
K
E
L
F
G
A
D
----
Y
----
A
----
N
V
Q
P
H
A
G
S
Q
A
N
S
A
V
Y
L
A
L
L
N
P
G
D
T
V
L
G
M
S
----------------------------------
Y
N
A
V
Q
Y
G
L
--
N
A
E
T
G
E
I
D
Y
E
E
V
E
R
L
A
L
E
H
K
P
R
M
I
V
A
G
F
S
A
Y
S
R
V
--
V
D
W
Q
R
F
R
D
I
A
D
K
V
G
A
Y
L
F
V
D
M
A
H
V
A
G
L
V
A
A
G
V
Y
P
N
P
V
Q
I
A
D
V
T
T
T
T
T
H
K
T
L
R
G
P
R
S
G
L
I
L
-------
A
K
A
-
N
E
E
------
I
-------------
E
K
--
K
L
Q
S
A
V
F
P
G
N
Q
G
G
P
L
M
H
A
I
A
A
K
A
I
C
F
K
E
A
M
S
D
D
F
K
A
Y
Q
Q
Q
V
V
K
N
A
Q
A
M
A
E
V
F
I
A
R
-
G
Y
D
V
V
S
G
G
T
D
N
H
L
F
L
L
S
L
I
K
Q
D
V
T
G
K
D
A
D
A
W
L
G
A
A
H
I
T
V
N
K
N
S
V
P
N
D
P
R
S
P
F
V
T
S
G
I
R
I
G
T
P
A
V
T
T
R
G
F
G
E
A
E
V
R
E
L
A
G
W
I
A
D
V
I
----------------------
D
-----------------------
S
K
G
D
E
------------------------
K
V
I
A
D
V
K
A
K
V
E
A
V
C
A
K
F
P
V
Y
A
K
34
PsiBlast_CBE
85.82
62%
-91
- C1 -
-
4OT8
4
?
D:
[15-422]
-------------
S
T
I
A
N
V
D
P
E
I
F
A
A
I
E
Q
E
N
R
R
Q
E
D
H
I
E
L
I
A
S
E
N
Y
T
S
P
A
V
M
A
A
Q
G
S
Q
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
V
V
E
Q
L
A
I
D
R
V
K
Q
L
F
G
A
E
----
A
----
A
----
N
V
Q
P
N
S
G
S
Q
A
N
Q
G
V
F
F
A
M
L
K
P
G
D
T
I
M
G
M
S
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
M
S
G
K
W
F
N
V
V
S
Y
G
L
--
N
-
E
N
E
D
I
D
Y
D
A
A
E
K
L
A
N
E
H
K
P
K
L
I
V
A
G
A
S
A
F
A
L
K
--
I
D
F
E
R
L
A
K
I
A
K
S
V
G
A
Y
L
M
V
D
M
A
H
Y
A
G
L
I
A
A
G
V
Y
P
N
P
V
P
H
A
D
F
V
T
T
T
T
H
K
S
L
R
G
P
R
G
G
V
I
L
-------
M
K
A
---
E
------
Y
-------------
E
K
--
P
I
N
S
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
K
E
A
L
S
P
E
F
K
E
Y
Q
Q
K
V
V
E
N
A
R
V
L
A
E
T
L
V
K
R
-
G
L
R
I
V
S
G
R
T
E
S
H
V
M
L
V
D
L
R
A
K
H
I
T
G
K
A
A
E
A
A
L
G
A
A
H
I
T
V
N
K
N
A
I
P
N
D
P
E
K
P
F
V
T
S
G
I
R
L
G
S
P
A
M
T
T
R
G
F
G
P
A
E
A
E
Q
V
G
N
L
I
A
D
V
L
----------------------
E
-----------------------
N
P
E
D
A
------------------------
A
T
I
E
R
V
R
A
Q
V
A
E
L
T
K
R
F
P
V
Y
--
33
PsiBlast_CBE
85.30
62%
-90
- C1 -
-
4OTL
5
?
B:
[15-422]
-------------
S
T
I
A
N
V
D
P
E
I
F
A
A
I
E
Q
E
N
R
R
Q
E
D
H
I
E
L
I
A
S
E
N
Y
T
S
P
A
V
M
A
A
Q
G
S
Q
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
V
V
E
Q
L
A
I
D
R
V
K
Q
L
F
G
A
E
----
A
----
A
----
N
V
Q
P
N
S
G
S
Q
A
N
Q
G
V
F
F
A
M
L
K
P
G
D
T
I
M
G
M
S
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
M
S
G
K
W
F
N
V
V
S
Y
G
L
--
N
-
E
N
E
D
I
D
Y
D
A
A
E
K
L
A
N
E
H
K
P
K
L
I
V
A
G
A
S
A
F
A
L
K
--
I
D
F
E
R
L
A
K
I
A
K
S
V
G
A
Y
L
M
V
D
M
A
H
Y
A
G
L
I
A
A
G
V
Y
P
N
P
V
P
H
A
D
F
V
T
T
T
T
H
K
S
L
R
G
P
R
G
G
V
I
L
-------
M
K
A
---
E
------
Y
-------------
E
K
--
P
I
N
S
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
K
E
A
L
S
P
E
F
K
E
Y
Q
Q
K
V
V
E
N
A
R
V
L
A
E
T
L
V
K
R
-
G
L
R
I
V
S
G
R
T
E
S
H
V
M
L
V
D
L
R
A
K
H
I
T
G
K
A
A
E
A
A
L
G
A
A
H
I
T
V
N
K
N
A
I
P
N
D
P
E
K
P
F
V
T
S
G
I
R
L
G
S
P
A
M
T
T
R
G
F
G
P
A
E
A
E
Q
V
G
N
L
I
A
D
V
L
----------------------
E
-----------------------
N
P
E
D
A
------------------------
A
T
I
E
R
V
R
A
Q
V
A
E
L
T
K
R
F
P
V
Y
--
36
PsiBlast_CBE
85.00
62%
-88
- C1 -
-
4OT8
4
?
B:
[13-422]
-----------
A
Q
S
T
I
A
N
V
D
P
E
I
F
A
A
I
E
Q
E
N
R
R
Q
E
D
H
I
E
L
I
A
S
E
N
Y
T
S
P
A
V
M
A
A
Q
G
S
Q
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
V
V
E
Q
L
A
I
D
R
V
K
Q
L
F
G
A
E
----
A
----
A
----
N
V
Q
P
N
S
G
S
Q
A
N
Q
G
V
F
F
A
M
L
K
P
G
D
T
I
M
G
M
S
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
M
S
G
K
W
F
N
V
V
S
Y
G
L
--
N
-
E
N
E
D
I
D
Y
D
A
A
E
K
L
A
N
E
H
K
P
K
L
I
V
A
G
A
S
A
F
A
L
K
--
I
D
F
E
R
L
A
K
I
A
K
S
V
G
A
Y
L
M
V
D
M
A
H
Y
A
G
L
I
A
A
G
V
Y
P
N
P
V
P
H
A
D
F
V
T
T
T
T
H
K
S
L
R
G
P
R
G
G
V
I
L
-------
M
K
A
---
E
------
Y
-------------
E
K
--
P
I
N
S
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
K
E
A
L
S
P
E
F
K
E
Y
Q
Q
K
V
V
E
N
A
R
V
L
A
E
T
L
V
K
R
-
G
L
R
I
V
S
G
R
T
E
S
H
V
M
L
V
D
L
R
A
K
H
I
T
G
K
A
A
E
A
A
L
G
A
A
H
I
T
V
N
K
N
A
I
P
N
D
P
E
K
P
F
V
T
S
G
I
R
L
G
S
P
A
M
T
T
R
G
F
G
P
A
E
A
E
Q
V
G
N
L
I
A
D
V
L
----------------------
E
-----------------------
N
P
E
D
A
------------------------
A
T
I
E
R
V
R
A
Q
V
A
E
L
T
K
R
F
P
V
Y
--
9
PsiBlast_PDB
84.62
62%
-90
- C1 -
-
4OTL
4
?
A:
[15-422]
-------------
S
T
I
A
N
V
D
P
E
I
F
A
A
I
E
Q
E
N
R
R
Q
E
D
H
I
E
L
I
A
S
E
N
Y
T
S
P
A
V
M
A
A
Q
G
S
Q
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
V
V
E
Q
L
A
I
D
R
V
K
Q
L
F
G
A
E
----
A
----
A
----
N
V
Q
P
N
S
G
S
Q
A
N
Q
G
V
F
F
A
M
L
K
P
G
D
T
I
M
G
M
S
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
M
S
G
K
W
F
N
V
V
S
Y
G
L
--
N
-
E
N
E
D
I
D
Y
D
A
A
E
K
L
A
N
E
H
K
P
K
L
I
V
A
G
A
S
A
F
A
L
K
--
I
D
F
E
R
L
A
K
I
A
K
S
V
G
A
Y
L
M
V
D
M
A
H
Y
A
G
L
I
A
A
G
V
Y
P
N
P
V
P
H
A
D
F
V
T
T
T
T
H
K
S
L
R
G
P
R
G
G
V
I
L
-------
M
K
A
---
E
------
Y
-------------
E
K
--
P
I
N
S
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
K
E
A
L
S
P
E
F
K
E
Y
Q
Q
K
V
V
E
N
A
R
V
L
A
E
T
L
V
K
R
-
G
L
R
I
V
S
G
R
T
E
S
H
V
M
L
V
D
L
R
A
K
H
I
T
G
K
A
A
E
A
A
L
G
A
A
H
I
T
V
N
K
N
A
I
P
N
D
P
E
K
P
F
V
T
S
G
I
R
L
G
S
P
A
M
T
T
R
G
F
G
P
A
E
A
E
Q
V
G
N
L
I
A
D
V
L
----------------------
E
-----------------------
N
P
E
D
A
------------------------
A
T
I
E
R
V
R
A
Q
V
A
E
L
T
K
R
F
P
V
Y
--
62
PsiBlast_CBE
84.29
59%
-93
- C1 -
-
2VMT
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
53
PsiBlast_CBE
84.27
59%
-94
- C1 -
-
2VMP
4
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
59
PsiBlast_CBE
84.07
59%
-92
- C1 -
-
2W7J
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
48
PsiBlast_CBE
83.88
59%
-93
- C1 -
-
2VGT
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
52
PsiBlast_CBE
83.63
59%
-93
- C1 -
-
2VMQ
5
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
16
PsiBlast_PDB
83.59
59%
-93
- C1 -
-
2VI8
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
63
PsiBlast_CBE
83.53
59%
-93
- C1 -
-
2VMS
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
45
PsiBlast_CBE
83.51
59%
-90
- C1 -
-
2VGW
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
18
PsiBlast_PDB
83.51
59%
-91
- C1 -
-
2VIA
4
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
64
PsiBlast_CBE
83.38
59%
-93
- C1 -
-
2VMR
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
49
PsiBlast_CBE
83.38
59%
-91
- C1 -
-
2VGS
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
56
PsiBlast_CBE
83.35
59%
-93
- C1 -
-
2W7M
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
54
PsiBlast_CBE
83.35
59%
-93
- C1 -
-
2VMO
4
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
47
PsiBlast_CBE
83.31
59%
-92
- C1 -
-
2VGU
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
66
PsiBlast_CBE
83.28
59%
-92
- C1 -
-
2VMY
7
?
B:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
51
PsiBlast_CBE
83.15
59%
-94
- C1 -
-
1YJY
1
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
M
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
61
PsiBlast_CBE
83.12
59%
-91
- C1 -
-
2VMU
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
50
PsiBlast_CBE
83.09
59%
-94
- C1 -
-
1YJZ
1
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
M
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
17
PsiBlast_PDB
83.09
59%
-92
- C1 -
-
2VIB
4
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
20
PsiBlast_PDB
82.92
59%
-94
- C1 -
-
2W7D
2
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
65
PsiBlast_CBE
82.84
59%
-94
- C1 -
-
2VMZ
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
55
PsiBlast_CBE
82.82
59%
-91
- C1 -
-
2VMN
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
41
PsiBlast_CBE
82.76
59%
-92
- C1 -
-
2W7H
3
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
68
PsiBlast_CBE
82.74
59%
-92
- C1 -
-
2VMX
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
69
PsiBlast_CBE
82.68
59%
-90
- C1 -
-
2VMW
4
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
11
PsiBlast_PDB
82.67
60%
-91
- C1 -
-
1KKJ
1
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
67
PsiBlast_CBE
82.60
59%
-92
- C1 -
-
2VMY
7
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
19
PsiBlast_PDB
82.51
59%
-91
- C1 -
-
2VI9
4
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
12
PsiBlast_PDB
82.46
60%
-89
- C1 -
-
1KKP
2
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
46
PsiBlast_CBE
82.40
59%
-92
- C1 -
-
2VGV
3
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
70
PsiBlast_CBE
82.39
59%
-92
- C1 -
-
2VMV
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
43
PsiBlast_CBE
82.29
59%
-90
- C1 -
-
2W7F
4
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
40
PsiBlast_CBE
82.28
60%
-90
- C1 -
-
1KL2
6
?
B:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
13
PsiBlast_PDB
82.12
60%
-93
- C1 -
-
1KL1
2
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
58
PsiBlast_CBE
82.08
59%
-91
- C1 -
-
2W7K
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
57
PsiBlast_CBE
82.06
59%
-93
- C1 -
-
2W7L
2
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
60
PsiBlast_CBE
81.96
59%
-91
- C1 -
-
2W7I
1
?
A:
[4-404]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
42
PsiBlast_CBE
81.93
59%
-90
- C1 -
-
2W7G
3
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
14
PsiBlast_PDB
81.92
60%
-90
- C1 -
-
1KL2
6
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
15
PsiBlast_PDB
81.91
59%
-93
- C1 -
-
1YJS
1
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
Q
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
44
PsiBlast_CBE
81.87
59%
-90
- C1 -
-
2W7E
3
?
A:
[8-404]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
---
E
Q
------
F
-------------
A
K
--
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
120
HHSearch
80.64
57%
-85
- C1 -
-
2DKJ
2
GLYA_THET8
B:
[6-407]
-----------------
K
R
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
A
A
----
W
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
-----
S
R
-----
V
-----
N
F
S
G
K
L
Y
K
V
V
S
Y
G
V
--
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
--
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-------
S
N
D
-
P
E
L
------
G
-------------
K
R
---
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
A
R
R
-
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
P
E
E
M
P
L
V
A
E
L
I
D
R
A
L
----------------------
L
-----------------------
E
G
P
S
----------------------------
E
A
L
R
E
E
V
R
R
L
A
L
A
H
P
M
P
--
5
PsiBlast_PDB
78.20
71%
-43
- C1 -
-
3G8M
1
GLYA_ECOLI
A:
[6-417]
-------------
M
N
I
A
D
Y
D
A
E
L
W
Q
A
M
E
Q
E
K
V
R
Q
E
E
H
I
E
L
I
A
S
E
N
Y
T
S
P
R
V
M
Q
A
Q
G
S
Q
L
T
N
K
F
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
Q
L
A
I
D
R
A
K
E
L
F
G
A
D
----
Y
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
F
A
V
Y
T
A
L
L
E
P
G
D
T
V
L
G
M
N
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
K
L
Y
N
I
V
P
Y
G
I
--
D
A
-
T
G
H
I
D
Y
A
D
L
E
K
Q
A
K
E
H
K
P
K
M
I
I
G
G
F
S
A
Y
S
G
V
--
V
D
W
A
K
M
R
E
I
A
D
S
I
G
A
Y
L
F
V
D
M
A
H
V
A
G
L
V
A
A
G
V
Y
P
N
P
V
P
H
A
H
V
V
T
T
T
T
H
K
T
L
A
G
P
R
G
G
L
I
L
-------
A
K
G
G
S
E
E
------
L
-------------
Y
K
--
K
L
N
S
A
V
F
P
G
G
Q
G
G
P
L
M
H
V
I
A
G
K
A
V
A
L
K
E
A
M
E
P
E
F
K
T
Y
Q
Q
Q
V
A
K
N
A
K
A
M
V
E
V
F
L
E
R
-
G
Y
K
V
V
S
G
G
T
D
N
H
L
F
L
V
D
L
V
D
K
N
L
T
G
K
E
A
D
A
A
L
G
R
A
N
I
T
V
N
K
N
S
V
P
N
D
P
K
S
P
F
V
T
S
G
I
R
V
G
T
P
A
I
T
R
R
G
F
K
E
A
E
A
K
E
L
A
G
W
M
C
D
V
L
----------------------
D
-----------------------
S
I
N
D
E
------------------------
A
V
I
E
R
I
K
G
K
V
L
D
I
C
A
R
Y
P
V
Y
A
-
76
PsiBlast_CBE
78.15
58%
-49
- C1 -
-
4WXF
2
GLYA_STRT1
C:
[23-428]
------------------
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
--
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-------
T
D
--
D
E
D
------
I
-------------
A
K
--
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
V
E
A
L
----------------------
E
-----------------------
N
H
D
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
75
PsiBlast_CBE
77.59
58%
-51
- C1 -
-
4WXG
3
GLYA_STRT1
A:
[23-428]
------------------
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
--
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-------
T
D
--
D
E
D
------
I
-------------
A
K
--
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
V
E
A
L
----------------------
E
-----------------------
N
H
D
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
74
PsiBlast_CBE
77.16
58%
-50
- C1 -
-
4WXG
2
GLYA_STRT1
C:
[23-428]
------------------
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
--
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-------
T
D
--
D
E
D
------
I
-------------
A
K
--
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
V
E
A
L
----------------------
E
-----------------------
N
H
D
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
77
PsiBlast_CBE
76.83
58%
-51
- C1 -
-
4WXF
4
GLYA_STRT1
A:
[23-428]
------------------
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
--
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-------
T
D
--
D
E
D
------
I
-------------
A
K
--
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
V
E
A
L
----------------------
E
-----------------------
N
H
D
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
83
PsiBlast_CBE
75.12
59%
-83
- C1 -
-
2DKJ
2
GLYA_THET8
A:
[6-382]
-----------------
K
R
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
A
A
----
W
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
-----
S
R
-----
V
-----
N
F
S
G
K
L
Y
K
V
V
S
Y
G
V
--
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
--
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-------
S
N
--
D
P
E
------
L
-------------
G
K
--
R
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
A
R
R
-
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
P
E
E
M
----
P
L
V
A
E
L
I
----------------------
D
--------------------------------------------------------------------------
82
PsiBlast_CBE
74.10
59%
-83
- C1 -
-
2DKJ
2
GLYA_THET8
B:
[6-382]
-----------------
K
R
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
A
A
----
W
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
-----
S
R
-----
V
-----
N
F
S
G
K
L
Y
K
V
V
S
Y
G
V
--
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
--
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-------
S
N
--
D
P
E
------
L
-------------
G
K
--
R
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
A
R
R
-
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
P
E
E
M
----
P
L
V
A
E
L
I
----------------------
D
--------------------------------------------------------------------------
105
HHSearch
68.79
45%
-21
- C1 -
-
1RV3
2
GLYC_RABIT
B:
[23-479]
-------------
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
----
P
QC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
-----
F
M
-----
T
DKKKI
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
--
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
-------
Y
R
R
-
G
-
V
------
R
SVDK
E
I
L
Y
-----
N
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
L
-
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
S
-
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
H
R
G
I
----------------------
E
-----------------------
L
T
V
Q
I
Q
D
D
T
GPRAT
L
K
E
F
K
E
K
L
A
GD
E
K
H
Q
R
A
V
R
A
L
R
Q
E
V
E
S
F
A
A
L
F
P
L
P
G
-
119
HHSearch
67.56
57%
-4
- C1 -
-
2VI8
3
?
A:
[2-404]
-------------
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
------------
P
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
E
--
Q
F
------
A
-------------
K
Q
---
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
122
HHSearch
67.48
57%
-2
* C1 *
-
2VMN
3
?
A:
[3-404]
--------------
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
------------
P
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
--
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-------
C
Q
E
--
Q
F
------
A
-------------
K
Q
---
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
E
-
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
G
L
V
L
----------------------
K
-----------------------
N
V
G
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
--------
85
PsiBlast_CBE
67.37
44%
-18
- C1 -
-
4PVF
3
GLYM_HUMAN
A:
[27-477]
--------------
S
L
S
D
S
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
L
D
----
P
----
A
Q
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
Y
M
S
DV
K
R
-----
I
-----
S
A
T
S
I
F
F
E
S
M
P
Y
K
L
--
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
--
I
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
F
Y
R
K
GVKA-------------
I
PY
T
F
---------
E
D
--
R
I
N
F
A
V
F
P
S
L
Q
G
G
P
H
N
H
A
I
A
A
V
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
L
E
R
-
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
P
G
D
-
R
S
A
I
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
E
D
D
F
R
R
V
V
D
F
I
D
E
G
V
N
I
G
L
E
V
K
S
K
TA
K
L
Q
D
F
K
S
F
L
L
K
D
-----------------------
S
E
T
S
Q
------------------------
R
-
L
A
N
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
---
116
HHSearch
66.53
54%
-4
- C1 -
-
4WXG
2
GLYA_STRT1
C:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
------------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
NV
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
-
S
-
A
Y
S
RI
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-------
T
D
D
-
E
D
I
------
A
-------------
K
K
---
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
V
E
A
L
----------------------
E
-----------------------
N
H
D
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
101
HHSearch
65.69
47%
2
- C1 -
-
4PVF
3
GLYM_HUMAN
A:
[22-479]
---------
W
T
G
Q
E
S
L
S
D
S
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
L
D
----
P
AQ
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
-----
Y
M
S
DVKR
I
-----
S
A
T
S
I
F
F
E
S
M
P
Y
K
L
--
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
--
I
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
F
-------
Y
R
K
-
G
V
K
AIPY
T
F
E
-------------
D
---
R
I
N
F
A
V
F
P
S
L
Q
G
G
P
H
N
H
A
I
A
A
V
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
L
E
R
-
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
P
G
D
R
-
S
A
I
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
E
D
D
F
R
R
V
V
D
F
I
D
E
G
V
----------------------
N
-----------------------
I
G
L
E
V
K
S
K
TA
K
L
Q
D
F
K
S
F
L
L
K
D
S
E
T
S
---
Q
R
L
A
N
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
P
G
-
84
PsiBlast_CBE
65.66
44%
-19
- C1 -
-
4PVF
2
GLYM_HUMAN
B:
[27-477]
--------------
S
L
S
D
S
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
L
D
----
P
----
A
QWGV
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
YMSDV
K
R
-----
I
-----
S
A
T
S
I
F
F
E
S
M
P
Y
K
L
--
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
--
I
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
F
YRKGVKA-------------
I
PYTF---------
E
D
--
R
I
N
F
A
V
F
P
S
L
Q
G
G
P
H
N
H
A
I
A
A
V
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
L
E
R
-
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
--------
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
E
D
D
F
R
R
V
V
D
F
I
D
E
G
V
NIGLEVKSKTAKLQDFKSFLLK
D
-----------------------
S
E
T
S
Q
------------------------
R
-
L
A
N
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
---
125
Fugue
62.28
45%
15
- C1 -
-
1BJ4
1
GLYC_HUMAN
A:
[1-470]
DA
D
L
W
S
S
H
D
A
M
L
A
Q
P
L
K
D
S
D
V
E
V
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
F
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
K
L
D
PQC
W
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
P
Y
K
V
--
N
P
D
T
G
Y
I
N
Y
D
Q
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
--
L
E
Y
A
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
A
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
-------
Y
R
K
-
G
V
K
------
S
VDPATG
K
E
I
L
Y
N
L
E
S
--
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
C
R
A
L
S
E
A
L
T
E
L
-
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
R
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
H
R
G
I
----------------------
E
L
T
L
Q
I
Q
S
D
T
GVAAT
L
K
E
F
K
E
R
L
A
G
D
K
Y
Q
------------------------
A
A
V
Q
A
L
R
E
E
V
E
S
F
A
S
L
F
P
L
P
G
L