@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLG6: (2017-11-02 )
MRFEKFTNRLQQALSDAQSLAMGKDHTAIAGIHILSTLLEEPSNISLLQQAGARLPELKQKLEQALKDAPTIANPTGDVNLNPEAVKALNLADRYAQKAGDEFLSTDWVLLGLAETGETKNILSAVGVTPDSLRKVIENIRGSDKVMSNNHEDQRDSLNKYTIDLTERALSGKLDPVIGRDDEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSLDLGSLLAGAKYRGEFEERLKAVLKDLAKHEGEIILFIDELHTLVGAGKGDGAMDAGNMLKPALARGELRCVGATTLDEYRQYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKEKYATHHGVQILDSAIIAAAKMSHRYITDRQLPDKAIDLIDEAASRIKMEIDSKPEALDKLDRRLIQLKMQLEAVKKDEDAGSKAEVTHLEKQIAEVEKEYNDLEEVWKAEKTLVEGTKQAQVELDKARIAFEKAQREGDLAEAARLQYGVIPELQKQLEQDEVAEENEEPKLIRTKVTENEIAEVVSAATGIPVAKMMQGEREKLLHMEEFLHDRVVGQDEAVVAVSNAVRRSRAGLSDPNRPSGSFLFLGPTGVGKTELTKALANFLFDSDDAMIRIDMSEFMEKHSVSRLVGAPPGYVGYEEGGVLTEAVRRKPYSVVLFDEVEKAHPDVFNILLQVLDDGRLTDSQGRVVDFKNTVIVMTSNLGSQDVRELGEGATDDEVRTIVMNAVSQHFRPEFINRIDELVIFHSLKKVQIRGIADIQLDRLRSRLVDRDMSLTVDDSAFDLLIDAGFDPVYGARPLKRAIQQQVENTLAQKILSGDFVAGDTILVKGENGHLVFDKLKLS
Atome Classification :
(33 SA)
.........10........20........30........40..--..--.------.--..50........60........70........80........90........100.......110......--.--120.......130-.......140.---.---.....----150...--....160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430..--.....440.......450.......460.......470.......480.......490.......500.......510-........520---.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720...---..-..-------730.-----......740.......750.......760.......770.......780..--.....790.......800.......810.......820.......830.......840.......850.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
F
E
K
F
T
N
R
L
Q
Q
A
L
S
D
A
Q
S
L
AMGKD
H
T
A
I
A
G
I
H
I
L
S
T
L
L
EEPS--
N
I
--
S
------
L
--
L
Q
Q
AGAR
L
P
E
L
K
Q
K
L
E
Q
A
L
KDAPTIANPTGDVNL
N
P
E
A
V
K
A
L
N
L
A
D
R
Y
A
Q
K
A
G
D
E
FLST
D
W
V
L
L
G
LAETGE--
T
--
K
N
I
L
S
AVGV
T
P
D
S
-
L
R
K
V
I
E
NIRGS---D---KVMSN----NH
E
D
Q
R
--DSLN
K
Y
T
I
D
L
T
E
R
A
LSGKLDPVIGR
D
D
E
I
R
R
T
I
Q
V
L
S
R
RTKNN
P
V
L
I
GEPGV
G
K
T
A
I
V
E
G
L
A
Q
R
I
VNGEVPEGLKN
K
R
V
L
S
L
D
L
G
S
L
L
AGAKYR
G
E
F
E
E
R
L
K
A
V
L
K
D
L
A
KHEG
E
I
I
L
F
I
D
E
L
H
T
L
VGAGKGDGAMDA
G
N
M
L
K
P
A
LARG
E
L
R
C
VGAT
T
L
D
E
Y
R
Q
Y
I
E
K
D
A
A
L
E
R
R
F
Q
K
V
LVDEPS
V
E
D
T
I
A
I
L
R
G
L
K
E
K
Y
A
TH
H
G
V
Q
I
L
D
S
A
I
I
A
A
A
K
MSHRYITDRQL
P
D
K
A
I
D
L
I
D
E
A
A
S
R
I
K
M
EIDSK
P
E
A
L
D
K
L
D
R
R
L
I
Q
L
K
M
Q
L
E
A
VKKDEDAGS--K
A
E
V
T
H
L
E
K
Q
I
A
E
V
E
K
E
Y
N
D
L
E
E
V
W
K
A
E
K
T
L
V
EGTKQ
A
Q
V
E
L
D
K
A
R
I
A
F
E
K
A
QREG
D
L
A
E
A
A
R
L
QYGV
I
P
E
L
Q
K
Q
L
E
--
Q
D
E
V
AEENEEP---
K
L
I
R
T
KV
T
E
N
E
I
A
E
V
V
S
AATGI
P
V
A
K
M
M
QG
E
R
E
K
L
L
H
M
E
E
F
L
H
D
RVVGQD
E
A
V
V
A
V
S
N
A
V
R
R
SRAGLSDPNRPSG
S
F
L
F
LGPTGV
G
K
T
E
L
T
K
A
L
A
N
F
LFDSDD
A
M
I
R
I
D
M
S
E
F
M
E
K
H
S
V
S
R
L
VGAPPGYVGYEEG
G
V
L
T
E
A
V
RRKP
Y
S
V
V
L
F
D
E
V
E
K
AH
P
D
V
F
N
I
L
L
Q
VLDDGRLTDSQG
R
V
V
D
FK
N
T
V
I
V
M
TSNLG
S
Q
D
V
R
E
---LG-EG-------A
T
D
D
-----
E
V
R
T
I
V
M
N
A
V
S
Q
HF
R
P
E
F
I
N
R
I
D
E
L
V
I
F
H
S
L
K
K
V
Q
I
RG
I
A
D
I
Q
L
D
R
L
R
S
R
L
--VDRDM
S
L
T
VDDS
A
F
D
L
L
IDAGFDPVYG
A
R
P
L
K
R
A
I
Q
Q
Q
V
E
N
T
L
A
Q
K
I
LSGDFVAG
D
T
I
L
V
KGENG
H
L
V
F
D
K
LKLS
65
Fugue
98.65
55%
0
- C- -
-
1QVR
-
CLPB_THET8
A:
[4-850]
---
E
R
W
T
Q
A
A
R
E
A
L
A
Q
A
Q
V
L
A
Q
R
M
K
H
Q
A
I
D
L
P
H
L
W
A
V
L
L
K
D
E
R
--
S
L
A
W
R
------
L
--
L
E
K
A
G
A
D
P
K
A
L
K
E
L
Q
E
R
E
L
A
R
L
P
K
V
E
G
A
E
V
G
Q
Y
L
T
S
R
L
S
G
A
L
N
R
A
E
G
L
M
E
E
L
K
D
R
Y
V
A
V
D
T
L
V
L
A
L
A
E
A
T
P
--
G
--
L
P
-------
G
L
E
A
-
L
K
G
A
L
K
E
L
R
G
G
---
R
---
T
V
Q
T
E
----
H
A
E
S
T
Y
--
N
A
L
E
Q
Y
G
I
D
L
T
R
L
A
A
E
G
K
L
D
P
V
I
G
R
D
E
E
I
R
R
V
I
Q
I
L
L
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
V
E
G
L
A
Q
R
I
V
K
G
D
V
P
E
G
L
K
G
K
R
I
V
S
L
Q
-----------
M
E
F
E
E
R
L
K
A
V
I
Q
E
V
V
Q
S
Q
G
E
V
I
L
F
I
D
E
L
-------------------
K
P
A
L
A
R
G
E
L
R
L
I
G
A
T
T
L
D
E
Y
R
E
I
-
E
K
D
P
A
L
E
R
R
F
Q
P
V
Y
V
D
E
P
T
V
E
E
T
I
S
I
L
R
G
L
K
E
K
Y
E
V
H
H
G
V
R
I
S
D
S
A
I
I
A
A
A
T
L
S
H
R
Y
I
T
E
R
R
L
P
D
K
A
I
D
L
I
D
E
A
A
A
R
L
R
M
A
L
E
S
A
P
E
E
I
D
A
L
E
R
K
K
L
Q
L
E
I
E
R
E
A
L
K
K
E
K
D
P
D
S
--
Q
E
R
L
K
A
I
E
A
E
I
A
K
L
T
E
E
I
A
K
L
R
A
E
W
E
R
E
R
E
I
L
R
K
L
R
E
A
Q
H
R
L
D
E
V
R
R
E
I
E
L
A
E
R
Q
Y
D
L
N
R
A
A
E
L
R
Y
G
E
L
P
K
L
E
A
E
V
E
--
A
L
S
--
E
K
L
R
G
A
---
R
F
V
R
L
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
Q
--------------
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
---
G
L
Q
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
A
--
32
PsiBlast_CBE
90.37
43%
0
- C- -
-
5VY9
4
?
B:
[6-871]
----
Q
F
T
E
R
A
L
T
I
L
T
L
A
Q
K
L
A
S
D
H
Q
H
P
Q
L
Q
P
I
H
I
L
A
A
F
I
E
T
P
E
--
D
G
--
S
VPYLQN
L
--
I
E
K
G
R
Y
D
Y
D
L
F
K
K
V
V
N
R
N
L
V
R
I
P
Q
Q
Q
P
A
P
A
E
I
T
P
S
Y
A
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
--
I
--
Q
Q
I
F
K
E
A
Q
V
D
I
E
A
-
I
K
Q
Q
A
L
E
L
R
G
--------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
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V
A
E
P
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V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
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S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
TT
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
K
H
G
H
E
E
L
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
Y
D
T
A
T
A
A
D
L
R
Y
F
A
I
P
D
I
K
K
Q
I
E
KL
E
D
Q
V
A
E
E
E
R
R
A
G
AN
S
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
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R
D
L
S
S
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V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
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V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
29
PsiBlast_CBE
90.37
43%
0
- C- -
-
5VY9
4
?
E:
[6-871]
----
Q
F
T
E
R
A
L
T
I
L
T
L
A
Q
K
L
A
S
D
H
Q
H
P
Q
L
Q
P
I
H
I
L
A
A
F
I
E
T
P
E
--
D
G
--
S
VPYLQN
L
--
I
E
K
G
R
Y
D
Y
D
L
F
K
K
V
V
N
R
N
L
V
R
I
P
Q
Q
Q
P
A
P
A
E
I
T
P
S
Y
A
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
--
I
--
Q
Q
I
F
K
E
A
Q
V
D
I
E
A
-
I
K
Q
Q
A
L
E
L
R
G
--------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
TT
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
K
H
G
H
E
E
L
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
Y
D
T
A
T
A
A
D
L
R
Y
F
A
I
P
D
I
K
K
Q
I
E
KL
E
D
Q
V
A
E
E
E
R
R
A
GAN
S
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
28
PsiBlast_CBE
90.37
43%
0
- C- -
-
5VY9
3
?
F:
[6-871]
----
Q
F
T
E
R
A
L
T
I
L
T
L
A
Q
K
L
A
S
D
H
Q
H
P
Q
L
Q
P
I
H
I
L
A
A
F
I
E
T
P
E
--
D
G
--
S
VPYLQN
L
--
I
E
K
G
R
Y
D
Y
D
L
F
K
K
V
V
N
R
N
L
V
R
I
P
Q
Q
Q
P
A
P
A
E
I
T
P
S
Y
A
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
--
I
--
Q
Q
I
F
K
E
A
Q
V
D
I
E
A
-
I
K
Q
Q
A
L
E
L
R
G
--------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
TT
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
K
H
G
H
E
E
L
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
Y
D
T
A
T
A
A
D
L
R
Y
F
A
I
P
D
I
K
K
Q
I
E
KL
E
D
Q
V
A
E
E
E
R
R
A
GAN
S
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
9
PsiBlast_PDB
90.37
43%
0
- C- -
-
5VY9
3
?
A:
[6-871]
----
Q
F
T
E
R
A
L
T
I
L
T
L
A
Q
K
L
A
S
D
H
Q
H
P
Q
L
Q
P
I
H
I
L
A
A
F
I
E
T
P
E
--
D
G
--
S
VPYLQN
L
--
I
E
K
G
R
Y
D
Y
D
L
F
K
K
V
V
N
R
N
L
V
R
I
P
Q
Q
Q
P
A
P
A
E
I
T
P
S
Y
A
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
--
I
--
Q
Q
I
F
K
E
A
Q
V
D
I
E
A
-
I
K
Q
Q
A
L
E
L
R
G
--------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
TT
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
K
H
G
H
E
E
L
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
Y
D
T
A
T
A
A
D
L
R
Y
F
A
I
P
D
I
K
K
Q
I
E
K
L
E
D
Q
V
A
E
E
E
R
R
A
GAN
S
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
31
PsiBlast_CBE
76.65
43%
0
- C- -
-
5VY9
4
?
C:
[6-871]
----
Q
F
T
E
R
A
L
T
I
L
T
L
A
Q
K
L
A
S
D
H
Q
H
P
Q
L
Q
P
I
H
I
L
A
A
F
I
E
T
P
E
--
D
G
--
S
VPYLQN
L
--
I
E
K
G
R
Y
D
Y
D
L
F
K
K
V
V
N
R
N
L
V
R
I
P
Q
Q
Q
P
A
P
A
E
I
T
P
S
Y
A
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
--
I
--
Q
Q
I
F
K
E
A
Q
V
D
I
E
A
-
I
K
Q
Q
A
L
E
L
R
G
--------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
--------------------------------------------------------------------------------------------------------------------------------
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
30
PsiBlast_CBE
76.65
43%
0
- C- -
-
5VY9
4
?
D:
[6-871]
----
Q
F
T
E
R
A
L
T
I
L
T
L
A
Q
K
L
A
S
D
H
Q
H
P
Q
L
Q
P
I
H
I
L
A
A
F
I
E
T
P
E
--
D
G
--
S
VPYLQN
L
--
I
E
K
G
R
Y
D
Y
D
L
F
K
K
V
V
N
R
N
L
V
R
I
P
Q
Q
Q
P
A
P
A
E
I
T
P
S
Y
A
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
--
I
--
Q
Q
I
F
K
E
A
Q
V
D
I
E
A
-
I
K
Q
Q
A
L
E
L
R
G
--------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
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V
E
K
D
G
A
F
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R
R
F
Q
K
I
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V
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S
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Q
T
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L
R
G
L
Q
P
K
Y
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I
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H
G
V
R
I
L
D
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A
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V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
--------------------------------------------------------------------------------------------------------------------------------
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
36
PsiBlast_CBE
74.27
43%
0
- C- -
-
5VY8
3
?
C:
[166-869]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
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R
Q
L
Q
L
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Q
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I
K
A
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D
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A
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TT
K
D
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L
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A
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K
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K
A
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Y
D
T
A
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A
D
L
R
Y
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A
I
P
D
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K
Q
I
E
KL
E
D
Q
V
A
E
E
E
R
R
A
GAN
S
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
35
PsiBlast_CBE
74.27
43%
0
- C- -
-
5VY8
3
?
D:
[166-869]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
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S
K
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Q
L
Q
L
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Q
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I
K
A
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D
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TT
K
D
R
L
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L
A
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L
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L
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A
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D
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M
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L
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L
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N
C
I
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I
M
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N
L
G
A
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I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
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M
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A
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H
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F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
34
PsiBlast_CBE
74.27
43%
0
- C- -
-
5VY8
3
?
E:
[166-869]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
TT
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
K
H
G
H
E
E
L
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
Y
D
T
A
T
A
A
D
L
R
Y
F
A
I
P
D
I
K
K
Q
I
E
KL
E
D
Q
V
A
E
E
E
R
R
A
GAN
S
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
76
HHSearch
69.83
51%
42
- C2 -
-
3J3U
-
CLPC_BACSU
B:
[3-802]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
--
K
------
A
--
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
---
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
--
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
ETG
S
---
S
A
A
G
T
----
N
S
N
A
N
T
--
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
-------
A
----------------
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
------
T
K
K
---------------------------
S
W
K
----------
E
K
Q
---
G
Q
E
N
S
E
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
---
N
K
Y
V
G
FN
V
Q
D
E
T
Q
N
H
K
-----
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
--
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
-------
4
PsiBlast_PDB
69.61
46%
37
- C2 -
-
3J3U
-
CLPC_BACSU
A:
[3-802]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
--
G
I
--
A
------
A
KA
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
GV
A
--
A
R
V
L
N
N
L
G
V
S
L
N
K
-
A
R
Q
Q
V
L
Q
L
L
G
S
---
N
---
E
T
G
S
S
AAGT
N
S
N
A
N
T
--
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
-
R
Q
A
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
--
A
A
S
L
R
D
T
E
Q
R
L
R
E
---
Q
V
E
D
T
K
K
S
W
K
E
K
----
Q
G
Q
E
N
S
E
V
T
V
D
-------------
D
I
A
M
V
V
S
S
W
T
------------------------------------------------------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
NKY
V
G
-
F
N
-------
V
Q
D
E
TQNHK
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
--
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
-------
77
HHSearch
69.25
50%
-
- C2 -
-
3PXI
-
CLPC_BACSU
A:
[3-805]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
GI
A
A
--
K
------
A
--
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
---
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
--
G
VA
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
---
E
TGS---------
N
S
N
A
N
T
--
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
I
I
L
F
I
D
A
--------------------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
--
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
-----------------------------
V
Q
S
Q
E
F
E
K
A
A
S
----
L
R
D
T
E
Q
R
L
R
E
Q
V
E
-----------------------
D
T
K
K
S
W
K
--
E
K
--------
Q
---
G
Q
E
---
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
--------------
S
---
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
K
D
K
-----------------------------
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
--
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
----
1
PsiBlast_PDB
69.17
46%
38
- C2 -
-
3J3S
-
CLPC_BACSU
A:
[3-802]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
--
G
I
--
A
------
A
KA
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
GV
A
--
A
R
V
L
N
N
L
G
V
S
L
N
K
-
A
R
Q
Q
V
L
Q
L
L
G
S
---
N
---
E
T
G
S
S
AAGT
N
S
N
A
N
T
--
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
-
R
Q
A
G
N
I
I
L
F
I
D
E
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
--
A
A
S
L
R
D
T
E
Q
R
L
R
E
---
Q
V
E
D
T
K
K
S
W
K
E
K
----
Q
G
Q
E
N
S
E
V
T
V
D
-------------
D
I
A
M
V
V
S
S
W
T
------------------------------------------------------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
NKY
V
G
-
F
N
-------
V
Q
D
E
TQNHK
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
--
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
-------
3
PsiBlast_PDB
68.00
46%
36
- C2 -
-
3J3R
-
CLPC_BACSU
A:
[3-802]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
--
G
I
--
A
------
A
KA
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
GV
A
--
A
R
V
L
N
N
L
G
V
S
L
N
K
-
A
R
Q
Q
V
L
Q
L
L
G
S
---
N
---
E
T
G
S
S
AAGT
N
S
N
A
N
T
--
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
-
R
Q
A
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
--
A
A
S
L
R
D
T
E
Q
R
L
R
E
---
Q
V
E
D
T
K
K
S
W
K
E
K
----
Q
G
Q
E
N
S
E
V
T
V
D
-------------
D
I
A
M
V
V
S
S
W
T
------------------------------------------------------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
NKY
V
G
-
F
N
-------
V
Q
D
E
TQNHK
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
--
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
-------
2
PsiBlast_PDB
67.22
46%
39
- C2 -
-
3J3T
-
CLPC_BACSU
A:
[3-802]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
--
G
I
--
A
------
A
KA
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
GV
A
--
A
R
V
L
N
N
L
G
V
S
L
N
K
-
A
R
Q
Q
V
L
Q
L
L
G
S
---
N
---
E
T
G
S
S
AAGT
N
S
N
A
N
T
--
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
-
R
Q
A
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
--
A
A
S
L
R
D
T
E
Q
R
L
R
E
---
Q
V
E
D
T
K
K
S
W
K
E
K
----
Q
G
Q
E
N
S
E
V
T
V
D
-------------
D
I
A
M
V
V
S
S
W
T
------------------------------------------------------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
NKY
V
G
-
F
N
-------
V
Q
D
E
TQNHK
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
--
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
-------
10
PsiBlast_PDB
66.67
44%
-
- C2 -
-
3PXI
-
CLPC_BACSU
A:
[3-802]
--
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
--
G
I
--
A
------
A
KA
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
M
S
Q
T
---
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
GV
A
--
A
R
V
L
N
N
L
G
V
S
L
N
K
-
A
R
Q
Q
V
L
Q
L
L
G
S
---
N
---
E
T
G
S
-----
N
S
N
A
N
T
--
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
-
R
Q
A
G
N
I
I
L
F
I
D
------------
A
--------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
--
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
--
A
A
S
L
R
D
T
E
Q
R
L
R
E
---
Q
V
E
D
T
K
K
S
W
K
E
K
----
Q
G
Q
---
E
V
T
V
D
-------------
D
I
A
M
V
V
S
S
W
T
------------------------------------------------------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
-----------------
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
-----------------------------
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
--
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
-------
22
PsiBlast_CBE
65.85
43%
51
- C2 -
-
5KNE
2
HS104_YEAST
D:
[1-852]
----
Q
F
T
E
R
A
L
T
I
L
T
L
A
Q
K
L
A
S
D
H
Q
H
P
Q
L
Q
P
I
H
I
L
A
A
F
I
E
T
P
E
--
D
G
--
S
VPYLQN
L
--
I
E
K
G
R
Y
D
Y
D
L
F
K
K
V
V
N
R
N
L
V
R
I
P
Q
Q
Q
P
A
P
A
E
I
T
P
S
Y
A
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
--
I
--
Q
Q
I
F
K
E
A
Q
V
D
I
E
A
-
I
K
Q
Q
A
L
E
L
R
G
N
---
T
---
R
I
D
S
R
----
G
A
D
T
N
T
PL
E
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
-------
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
----
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
TT
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
-------------------------------------------------------------------
S
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
----
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
21
PsiBlast_CBE
61.94
43%
-6
- C2 -
-
5KNE
3
HS104_YEAST
E:
[160-852]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
-------
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
----
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
TT
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
-------------------------------------------------------------------
S
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
-----
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
EQ
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
42
PsiBlast_CBE
61.61
43%
0
- C- -
-
5VJH
4
?
B:
[165-871]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
N
G
K
D
D
A
A
----
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
-------------------------------------------------------------------------------------------------------------------------------
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
A
-
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
-
G
S
-------
K
I
Q
E
-----
S
T
K
N
L
V
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
Q
N
D
K
H
Y
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
K
N
E
I
K
D
K
E
T
V
N
V
---------------
13
PsiBlast_PDB
57.65
64%
-84
- C2 -
-
4LJ5
1
A:
[5-331]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
----
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
14
PsiBlast_PDB
56.88
64%
-79
- C2 -
-
4LJ7
1
CLPB_THET8
A:
[30-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
15
PsiBlast_PDB
56.87
64%
-75
- C2 -
-
4LJ9
1
A:
[5-331]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
45
PsiBlast_CBE
56.75
64%
-87
- C2 -
-
4LJ7
1
CLPB_THET8
B:
[34-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
80
HHSearch
56.57
64%
-70
* C2 *
-
4LJ9
1
A:
[5-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
---
G
L
Q
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
---------
16
PsiBlast_PDB
56.35
64%
-80
- C2 -
-
4LJA
2
A:
[5-331]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
----
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
47
PsiBlast_CBE
56.08
64%
-90
- C2 -
-
4FD2
1
CLPB_THET8
B:
[13-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
20
PsiBlast_PDB
56.01
63%
-87
- C2 -
-
4FCW
1
CLPB_THET8
A:
[16-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
46
PsiBlast_CBE
55.42
64%
-86
- C2 -
-
4FD2
1
D:
[13-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
44
PsiBlast_CBE
55.36
64%
-85
- C2 -
-
4LJ7
1
C:
[34-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
18
PsiBlast_PDB
55.30
64%
-85
- C2 -
-
4FD2
1
CLPB_THET8
A:
[13-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------
82
HHSearch
55.19
64%
-76
- C2 -
-
4FCV
1
CLPB_THET8
A:
[7-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
---
G
L
Q
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
----------
19
PsiBlast_PDB
54.82
63%
-79
- C2 -
-
4FCV
1
CLPB_THET8
A:
[16-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
--
L
Q
-
K
G
-------
W
P
Y
E
-----
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
--
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
------