@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLM0: (2017-11-03 )
MSKMKSPILRLRRLRRTKAIRGLLCENNFSVEDLVQPIFIEESITQPIPISTMPGIYRLPEQDIEQEVKALYALGIRCVMPFGISHHKDSMGSDTWSDTGLLVRMIKAIKSSCPEMIVTPDICFCEYTTHGHCGVMIHDQISNDLTVENLIKQSLAAAKAGADMLAPSGMMDGQVGAIREALDQAGYHNVLIMAHAIKFASALYGPFRVAVDSNLVGDRHSYQLDYANTRQALREAALDESEGADLLIVKPGMFYLDILSQLRAQTKLPLAAYQVGGEYAAIKFAAIAKALDERKTVIESITAFKRAGADVIITYFAKDIAIWHNEF
Atome Classification :
(41 SA)
.........10........20........30........40........50........60.-.......70........80..---.--.--.---.--..90........100.......110..-.....120.......130.......----140.......150.......160.......170.......180.....-.-.-190.......200......-.210--.-.-.-.---...220.......230.......240.......250.......260.-..-.-.-..270.......280.......290.......300.......310.......320.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSK
M
K
S
P
I
L
R
L
R
R
L
R
R
T
K
A
I
R
G
L
LCENNF
S
V
E
D
L
V
Q
P
I
F
I
EESITQPIPISTMPGIYRL
P
E
Q
-
D
I
E
Q
E
V
K
A
L
Y
A
LGI
R
C
VMPFG---I--S--H---H--KDSMGSDTWS
D
T
G
L
L
V
R
M
I
K
A
I
K
SSCP-
E
M
IVTP
D
I
C
F
C
EYTTHG
H
C
G
V
M
I
HD----QISND
L
T
V
E
N
L
I
K
Q
S
L
A
A
A
KAGADMLAPSGMMDG
Q
V
G
A
I
R
E
A
L
D
QAGY-H-N-
V
L
I
M
A
H
A
I
K
F
A
S
A
LYG
P
F
R
-
V
A
VD--S-N-L-V---GDRH
S
Y
Q
LDY
A
N
T
R
Q
A
L
R
E
AALDESEGA
D
L
L
I
VKP
G
M
F
Y
L
D
I
L
S
Q
L
R
-
A
Q-T-K-L
P
L
A
A
Y
QVGG
E
Y
A
A
I
K
F
A
A
I
A
K
A
L
D
E
R
K
T
V
I
E
S
I
T
A
F
K
RAGA
D
V
I
I
T
Y
F
A
K
D
I
A
I
WHNEF
2
PsiBlast_PDB
90.37
54%
-112
- C7 -
-
1L6S
1
HEM2_ECOLI
A:
[4-317]
-------
I
Q
R
P
R
R
L
R
K
S
P
A
L
R
A
M
F
E
E
T
T
L
S
L
N
D
L
V
L
P
I
F
V
E
E
E
I
D
D
Y
K
A
V
E
A
M
P
G
V
M
R
I
P
E
K
-
H
L
A
R
E
I
E
R
I
A
N
A
G
I
R
S
V
M
T
F
G
---
I
--
S
--
H
---
H
--
T
D
E
T
G
S
D
A
W
R
E
D
G
L
V
A
R
M
S
R
I
C
K
Q
T
V
P
-
E
M
I
V
M
S
D
T
C
F
C
E
Y
T
S
H
G
H
C
G
V
L
C
E
H
----
G
V
D
N
D
A
T
L
E
N
L
G
K
Q
A
V
V
A
A
A
A
G
A
D
F
I
A
P
S
A
A
M
D
G
Q
V
Q
A
I
R
Q
A
L
D
A
A
G
F
-
K
-
D
-
T
A
I
M
S
Y
S
T
K
F
A
S
S
F
Y
G
P
F
R
-
E
A
A
G
--
S
-
A
-
L
-
K
---
G
D
R
K
S
Y
Q
M
N
P
M
N
R
R
E
A
I
R
E
S
L
L
D
E
A
Q
G
A
D
C
L
M
V
K
P
A
G
A
Y
L
D
I
V
R
E
L
R
-
E
R
-
T
-
E
-
L
P
I
G
A
Y
Q
V
S
G
E
Y
A
M
I
K
F
A
A
L
A
G
A
I
D
E
E
K
V
V
L
E
S
L
G
S
I
K
R
A
G
A
D
L
I
F
S
Y
F
A
L
D
L
A
------
3
PsiBlast_PDB
89.85
54%
-115
- C7 -
-
1L6Y
4
HEM2_ECOLI
A:
[4-317]
-------
I
Q
R
P
R
R
L
R
K
S
P
A
L
R
A
M
F
E
E
T
T
L
S
L
N
D
L
V
L
P
I
F
V
E
E
E
I
D
D
Y
K
A
V
E
A
M
P
G
V
M
R
I
P
E
K
-
H
L
A
R
E
I
E
R
I
A
N
A
G
I
R
S
V
M
T
F
G
---
I
--
S
--
H
---
H
--
T
D
E
T
G
S
D
A
W
R
E
D
G
L
V
A
R
M
S
R
I
C
K
Q
T
V
P
-
E
M
I
V
M
S
D
T
C
F
C
E
Y
T
S
H
G
H
C
G
V
L
C
E
H
----
G
V
D
N
D
A
T
L
E
N
L
G
K
Q
A
V
V
A
A
A
A
G
A
D
F
I
A
P
S
A
A
M
D
G
Q
V
Q
A
I
R
Q
A
L
D
A
A
G
F
-
K
-
D
-
T
A
I
M
S
Y
S
T
K
F
A
S
S
F
Y
G
P
F
R
-
E
A
A
G
--
S
-
A
-
L
-
K
---
G
D
R
K
S
Y
Q
M
N
P
M
N
R
R
E
A
I
R
E
S
L
L
D
E
A
Q
G
A
D
C
L
M
V
K
P
A
G
A
Y
L
D
I
V
R
E
L
R
-
E
R
-
T
-
E
-
L
P
I
G
A
Y
Q
V
S
G
E
Y
A
M
I
K
F
A
A
L
A
G
A
I
D
E
E
K
V
V
L
E
S
L
G
S
I
K
R
A
G
A
D
L
I
F
S
Y
F
A
L
D
L
A
------
4
PsiBlast_PDB
89.57
54%
-110
- C7 -
-
1I8J
1
HEM2_ECOLI
A:
[4-317]
-------
I
Q
R
P
R
R
L
R
K
S
P
A
L
R
A
M
F
E
E
T
T
L
S
L
N
D
L
V
L
P
I
F
V
E
E
E
I
D
D
Y
K
A
V
E
A
M
P
G
V
M
R
I
P
E
K
-
H
L
A
R
E
I
E
R
I
A
N
A
G
I
R
S
V
M
T
F
G
---
I
--
S
--
H
---
H
--
T
D
E
T
G
S
D
A
W
R
E
D
G
L
V
A
R
M
S
R
I
C
K
Q
T
V
P
-
E
M
I
V
M
S
D
T
C
F
C
E
Y
T
S
H
G
H
C
G
V
L
C
E
H
----
G
V
D
N
D
A
T
L
E
N
L
G
K
Q
A
V
V
A
A
A
A
G
A
D
F
I
A
P
S
A
A
M
D
G
Q
V
Q
A
I
R
Q
A
L
D
A
A
G
F
-
K
-
D
-
T
A
I
M
S
Y
S
T
K
F
A
S
S
F
Y
G
P
F
R
-
E
A
A
G
--
S
-
A
-
L
-
K
---
G
D
R
K
S
Y
Q
M
N
P
M
N
R
R
E
A
I
R
E
S
L
L
D
E
A
Q
G
A
D
C
L
M
V
K
P
A
G
A
Y
L
D
I
V
R
E
L
R
-
E
R
-
T
-
E
-
L
P
I
G
A
Y
Q
V
S
G
E
Y
A
M
I
K
F
A
A
L
A
G
A
I
D
E
E
K
V
V
L
E
S
L
G
S
I
K
R
A
G
A
D
L
I
F
S
Y
F
A
L
D
L
A
------
5
PsiBlast_PDB
89.26
54%
-112
- C7 -
-
1B4E
4
HEM2_ECOLI
A:
[6-317]
---------
R
P
R
R
L
R
K
S
P
A
L
R
A
M
F
E
E
T
T
L
S
L
N
D
L
V
L
P
I
F
V
E
E
E
I
D
D
Y
K
A
V
E
A
M
P
G
V
M
R
I
P
E
K
-
H
L
A
R
E
I
E
R
I
A
N
A
G
I
R
S
V
M
T
F
G
---
I
--
S
--
H
---
H
--
T
D
E
T
G
S
D
A
W
R
E
D
G
L
V
A
R
M
S
R
I
C
K
Q
T
V
P
-
E
M
I
V
M
S
D
T
C
F
C
E
Y
T
S
H
G
H
C
G
V
L
K
E
H
----
G
V
D
N
D
A
T
L
E
N
L
G
K
Q
A
V
V
A
A
A
A
G
A
D
F
I
A
P
S
A
A
M
D
G
Q
V
Q
A
I
R
Q
A
L
D
A
A
G
F
-
K
-
D
-
T
A
I
M
S
Y
S
T
K
F
A
S
S
F
Y
G
P
F
R
-
E
A
A
G
--
S
-
A
-
L
-
K
---
G
D
R
K
S
Y
Q
M
N
P
M
N
R
R
E
A
I
R
E
S
L
L
D
E
A
Q
G
A
D
C
L
M
V
K
P
A
G
A
Y
L
D
I
V
R
E
L
R
-
E
R
-
T
-
E
-
L
P
I
G
A
Y
Q
V
S
G
E
Y
A
M
I
K
F
A
A
L
A
G
A
I
D
E
E
K
V
V
L
E
S
L
G
S
I
K
R
A
G
A
D
L
I
F
S
Y
F
A
L
D
L
A
------
21
PsiBlast_CBE
88.95
54%
-111
- C7 -
-
1I8J
1
HEM2_ECOLI
B:
[4-317]
-------
I
Q
R
P
R
R
L
R
K
S
P
A
L
R
A
M
F
E
E
T
T
L
S
L
N
D
L
V
L
P
I
F
V
E
E
E
I
D
D
Y
K
A
V
E
A
M
P
G
V
M
R
I
P
E
K
-
H
L
A
R
E
I
E
R
I
A
N
A
G
I
R
S
V
M
T
F
G
---
I
--
S
--
H
---
H
--
T
D
E
T
G
S
D
A
W
R
E
D
G
L
V
A
R
M
S
R
I
C
K
Q
T
V
P
-
E
M
I
V
M
S
D
T
C
F
C
E
Y
T
S
H
G
H
C
G
V
L
C
E
H
----
G
V
D
N
D
A
T
L
E
N
L
G
K
Q
A
V
V
A
A
A
A
G
A
D
F
I
A
P
S
A
A
M
D
G
Q
V
Q
A
I
R
Q
A
L
D
A
A
G
F
-
K
-
D
-
T
A
I
M
S
Y
S
T
K
F
A
S
S
F
Y
G
P
F
R
-
E
A
A
G
--
S
-
A
-
L
-
K
---
G
D
R
K
S
Y
Q
M
N
P
M
N
R
R
E
A
I
R
E
S
L
L
D
E
A
Q
G
A
D
C
L
M
V
K
P
A
G
A
Y
L
D
I
V
R
E
L
R
-
E
R
-
T
-
E
-
L
P
I
G
A
Y
Q
V
S
G
E
Y
A
M
I
K
F
A
A
L
A
G
A
I
D
E
E
K
V
V
L
E
S
L
G
S
I
K
R
A
G
A
D
L
I
F
S
Y
F
A
L
D
L
A
------
1
PsiBlast_PDB
88.75
54%
-115
- C7 -
-
5MHB
4
HEM2_ECOLI
A:
[2-318]
----
T
D
L
I
Q
R
P
R
R
L
R
K
S
P
A
L
R
A
M
F
E
E
T
T
L
S
L
N
D
L
V
L
P
I
F
V
E
E
E
I
D
D
Y
K
A
V
E
A
M
P
G
V
M
R
I
P
E
K
-
H
L
A
R
E
I
E
R
I
A
N
A
G
I
R
S
V
M
T
F
G
---
I
--
S
--
H
---
H
--
T
D
E
T
G
S
D
A
W
R
E
D
G
L
V
A
R
M
S
R
I
C
K
Q
T
V
P
-
E
M
I
V
M
S
D
T
C
F
C
E
Y
T
S
H
G
H
C
G
V
L
C
E
H
----
G
V
D
N
D
A
T
L
E
N
L
G
K
Q
A
V
V
A
A
A
A
G
A
D
F
I
A
P
S
A
A
M
D
G
Q
V
Q
A
I
R
Q
A
L
D
A
A
G
F
-
K
-
D
-
T
A
I
M
S
Y
S
T
K
F
A
S
S
F
Y
G
P
F
R
-
E
A
A
G
--
S
-
A
-
L
-
K
---
G
D
R
K
S
Y
Q
M
N
P
M
N
R
R
E
A
I
R
E
S
L
L
D
E
A
Q
G
A
D
C
L
M
V
K
P
A
G
A
Y
L
D
I
V
R
E
L
R
-
E
R
-
T
-
E
-
L
P
I
G
A
Y
Q
V
S
G
E
Y
A
M
I
K
F
A
A
L
A
G
A
I
D
E
E
K
V
V
L
E
S
L
G
S
I
K
R
A
G
A
D
L
I
F
S
Y
F
A
L
D
L
A
------
90
HHSearch
87.10
53%
-88
- C7 -
-
1L6S
1
HEM2_ECOLI
A:
[1-321]
----
T
D
L
I
Q
R
P
R
R
L
R
K
S
P
A
L
R
A
M
F
E
E
T
T
L
S
L
N
D
L
V
L
P
I
F
V
E
E
E
I
D
D
Y
K
A
V
E
A
M
P
G
V
M
R
I
P
E
K
-
H
L
A
R
E
I
E
R
I
A
N
A
G
I
R
S
V
M
T
F
G
---
I
--
S
--
H
---
H
--
T
D
E
T
G
S
D
A
W
R
E
D
G
L
V
A
R
M
S
R
I
C
K
Q
T
V
P
-
E
M
I
V
M
S
D
T
C
F
C
E
Y
T
S
H
G
H
C
G
V
L
C
E
H
----
G
V
D
N
D
A
T
L
E
N
L
G
K
Q
A
V
V
A
A
A
A
G
A
D
F
I
A
P
S
A
A
M
D
G
Q
V
Q
A
I
R
Q
A
L
D
A
A
G
F
-
K
-
D
-
T
A
I
M
S
Y
S
T
K
F
A
S
S
F
Y
G
P
F
R
-
E
A
A
G
--
S
A
L
---
K
---
G
D
R
K
S
Y
Q
M
N
P
M
N
R
R
E
A
I
R
E
S
L
L
D
E
A
Q
G
A
D
C
L
M
V
K
P
A
G
A
Y
L
D
I
V
R
E
L
R
-
E
R
-
T
-
E
-
L
P
I
G
A
Y
Q
V
S
G
E
Y
A
M
I
K
F
A
A
L
A
G
A
I
D
E
E
K
V
V
L
E
S
L
G
S
I
K
R
A
G
A
D
L
I
F
S
Y
F
A
L
D
L
A
E
K
K
I
--
87
HHSearch
84.99
43%
-96
* C7 *
-
2C1H
1
HEM2_CHLP8
B:
[10-328]
-------
V
H
R
P
R
R
L
R
R
T
A
A
L
R
N
L
V
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
-
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
--
E
---
Q
--
K
T
E
D
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
-
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
K
D
G
----
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
-
D
A
L
H
--
S
A
P
-
Q
-
F
---
G
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
-
E
R
-
F
-
D
-
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
K
K
L
R
--
14
PsiBlast_PDB
83.19
43%
-101
- C7 -
-
2C1H
1
HEM2_CHLP8
A:
[25-324]
----------------------
L
V
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
-
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
--
E
---
Q
--
K
T
E
D
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
-
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
K
D
G
----
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
-
D
A
L
H
--
S
-
A
P
Q
-
F
---
G
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
-
E
R
-
F
-
D
-
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
------
46
PsiBlast_CBE
82.90
43%
-98
- C7 -
-
2C1H
1
HEM2_CHLP8
B:
[25-324]
----------------------
L
V
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
-
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
--
E
---
Q
--
K
T
E
D
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
-
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
K
D
G
----
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
-
D
A
L
H
--
S
-
A
P
Q
-
F
---
G
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
-
E
R
-
F
-
D
-
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
------
13
PsiBlast_PDB
81.66
43%
-97
- C7 -
-
1W1Z
1
HEM2_CHLP8
A:
[25-324]
----------------------
L
V
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
-
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
--
E
---
Q
--
K
T
E
D
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
-
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
K
D
G
----
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
-
D
A
L
H
--
S
-
A
P
Q
-
F
---
G
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
-
E
R
-
F
-
D
-
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
------
25
PsiBlast_CBE
80.34
43%
-48
- C7 -
-
1W5N
1
HEM2_PSEAE
B:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
A
L
C
P
F
T
T
H
G
Q
C
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
S------------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
60
PsiBlast_CBE
79.72
38%
-61
- C7 -
-
1H7R
1
HEM2_YEAST
A:
[27-340]
-------------------
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
V
P
L
I
--
P
--
G
---
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
A
H
-
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
D
A
A
C
S
--
A
-
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
-
C
-
K
D
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
26
PsiBlast_CBE
79.70
43%
-45
- C7 -
-
1W5M
1
HEM2_PSEAE
B:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
C
L
D
P
F
T
T
H
G
Q
C
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
S------------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
91
HHSearch
79.38
44%
-42
- C7 -
-
5LZL
-
?
G:
[3-334]
---
V
Q
F
P
T
T
R
P
R
R
L
R
A
S
K
I
I
R
D
A
V
A
E
T
Q
I
D
A
G
D
F
I
Y
P
L
F
V
K
P
G
G
-
E
R
E
P
I
G
P
M
P
G
I
Y
R
W
P
V
G
R
E
L
I
N
H
V
E
E
A
L
S
L
G
I
N
K
F
I
L
F
G
---
V
--
L
--
P
---
D
EL
K
N
P
E
G
T
G
G
Y
D
P
E
G
V
V
P
R
A
I
R
L
I
K
E
I
F
G
D
R
V
L
V
F
A
D
V
C
L
C
E
Y
T
D
H
G
H
C
G
V
V
K
E
K
RDRW
Y
V
D
N
D
E
T
I
K
L
Y
A
K
E
A
V
V
Y
A
E
A
G
A
D
F
V
A
P
S
G
M
M
D
G
Q
V
R
E
I
R
R
A
L
D
A
H
G
F
-
E
-
E
-
V
G
I
M
A
Y
S
A
K
Y
A
S
A
F
Y
G
P
F
R
-
V
A
A
A
--
S
A
P
-
K
-
F
---
G
D
R
R
T
Y
Q
M
D
P
R
N
A
Y
E
A
L
K
E
V
A
M
D
L
E
E
G
A
D
I
V
M
V
K
P
A
L
A
Y
L
D
V
I
R
L
V
K
-
Q
H
-
F
P
W
-
V
P
L
A
A
Y
N
V
S
G
E
Y
S
L
V
K
A
A
A
T
A
G
Y
V
D
E
R
T
I
T
L
E
I
L
T
A
I
K
R
A
G
A
D
L
I
L
T
Y
H
A
L
E
A
A
K
W
I
K
E
-
22
PsiBlast_CBE
79.29
44%
-36
- C7 -
-
1W5Q
1
HEM2_PSEAE
B:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
C
L
C
E
F
T
T
H
G
Q
C
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
------------------
N
R
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
8
PsiBlast_PDB
79.25
43%
-46
- C7 -
-
1W5N
1
HEM2_PSEAE
A:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
A
L
C
P
F
T
T
H
G
Q
C
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
S------------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
24
PsiBlast_CBE
79.13
43%
-46
- C7 -
-
1W5O
1
HEM2_PSEAE
B:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
C
L
C
P
F
T
T
H
G
Q
C
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
S------------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
88
HHSearch
79.06
44%
-35
- C7 -
-
1W5Q
1
HEM2_PSEAE
B:
[7-335]
--
N
R
A
Y
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
--
P
---
V
EK
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
C
L
C
E
F
T
T
H
G
Q
C
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
------------------
N
R
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
-
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
-
6
PsiBlast_PDB
79.01
43%
-41
- C7 -
-
1W5P
6
HEM2_PSEAE
A:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
C
L
C
E
F
T
T
H
G
Q
C
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
--------------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
47
PsiBlast_CBE
78.84
43%
-92
- C7 -
-
1W1Z
1
HEM2_CHLP8
B:
[25-324]
----------------------
L
V
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
-
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
--
E
---
Q
--
K
T
E
D
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
-
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
K
D
G
----
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
-
D
A
L
H
--
S
-
A
P
Q
-
F
---
G
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
-
E
R
-
F
-
D
-
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
------
93
HHSearch
78.37
37%
-57
- C7 -
-
1H7N
1
HEM2_YEAST
A:
[10-340]
--
E
P
T
E
I
S
S
V
L
A
G
G
Y
N
H
P
L
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
---
V
--
P
--
L
IPG
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
-
A
H
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
-
D
A
A
C
--
S
A
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
C
K
-
D
-
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
27
PsiBlast_CBE
78.09
43%
-45
- C7 -
-
1W56
1
HEM2_PSEAE
B:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
C
L
C
P
F
T
T
H
G
Q
D
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
S------------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
9
PsiBlast_PDB
78.06
43%
-22
- C7 -
-
1W56
1
HEM2_PSEAE
A:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
C
L
C
P
F
T
T
H
G
Q
D
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
SA
S
-
N
-
L
G
K
---
G
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
53
PsiBlast_CBE
77.74
38%
-58
- C7 -
-
1H7O
1
HEM2_YEAST
A:
[27-340]
-------------------
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
V
P
L
I
--
P
--
G
---
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
A
H
-
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
D
A
A
C
S
--
A
-
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
-
C
-
K
D
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
54
PsiBlast_CBE
77.66
38%
-58
- C7 -
-
1GJP
1
HEM2_YEAST
A:
[27-340]
-------------------
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
V
P
L
I
--
P
--
G
---
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
A
H
-
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
D
A
A
C
S
--
A
-
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
-
C
-
K
D
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
23
PsiBlast_CBE
77.60
43%
-39
- C7 -
-
1W5P
10
HEM2_PSEAE
B:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
C
L
C
E
F
T
T
H
G
Q
C
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
--------------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
62
PsiBlast_CBE
77.36
38%
-58
- C7 -
-
1H7N
1
HEM2_YEAST
A:
[27-340]
-------------------
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
V
P
L
I
--
P
--
G
---
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
A
H
-
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
D
A
A
C
S
--
A
-
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
-
C
-
K
D
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
59
PsiBlast_CBE
77.30
38%
-57
- C7 -
-
1OHL
2
HEM2_YEAST
A:
[27-340]
-------------------
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
V
P
L
I
--
P
--
G
---
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
A
H
-
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
D
A
A
C
S
--
A
-
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
-
C
-
K
D
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
77
Fugue
77.21
42%
-36
- C7 -
-
1B4K
1
HEM2_PSEAE
A:
[10-335]
----
Y
P
Y
-
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
TP
V
--
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
A
L
D
P
F
T
T
H
G
Q
D
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
T--
N
-
V
R
I
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
--
S
-
A
-
S
-
N
LGK
G
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
F
R
---
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
-
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
-
55
PsiBlast_CBE
77.21
38%
-58
- C7 -
-
1EB3
1
HEM2_YEAST
A:
[27-340]
-------------------
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
V
PL
I
--
P
--
G
---
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
A
H
-
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
D
A
A
C
S
--
A
-
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
-
C
-
K
D
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
61
PsiBlast_CBE
77.17
38%
-58
- C7 -
-
1H7P
1
HEM2_YEAST
A:
[27-340]
-------------------
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
V
P
L
I
--
P
--
G
---
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
A
H
-
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
D
A
A
C
S
--
A
-
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
-
C
-
K
D
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
56
PsiBlast_CBE
77.09
38%
-60
- C7 -
-
1W31
1
HEM2_YEAST
A:
[27-340]
-------------------
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
V
P
L
I
--
P
--
G
---
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
A
H
-
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
D
A
A
C
S
--
A
-
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
-
C
-
K
D
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
16
PsiBlast_PDB
77.01
42%
-19
- C7 -
-
2WOQ
7
HEM2_PSEAE
A:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
A
L
D
P
F
T
T
H
G
Q
D
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
I
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
SA
S
-
N
-
L
G
K
---
G
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
10
PsiBlast_PDB
76.80
43%
-21
- C7 -
-
1W5M
1
HEM2_PSEAE
A:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
C
L
D
P
F
T
T
H
G
Q
C
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
SA
S
-
N
-
L
G
K
---
G
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
52
PsiBlast_CBE
76.40
38%
-55
- C7 -
-
1YLV
1
HEM2_YEAST
A:
[27-340]
-------------------
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
V
P
L
I
--
P
--
G
---
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
K
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
A
H
-
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
D
A
A
C
S
--
A
-
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
-
C
-
K
D
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
T
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
94
HHSearch
76.38
37%
-58
- C7 -
-
1EB3
1
HEM2_YEAST
A:
[12-340]
----
T
E
I
S
S
V
L
A
G
G
Y
N
H
P
L
L
R
Q
W
Q
S
E
R
Q
L
T
K
N
M
L
I
F
P
L
F
I
S
D
N
P
D
D
F
T
E
I
D
S
L
P
N
I
N
R
I
G
V
N
-
R
L
K
D
Y
L
K
P
L
V
A
K
G
L
R
S
V
I
L
F
G
---
V
--
P
--
L
IPG
T
--
K
D
P
V
G
T
A
A
D
D
P
A
G
P
V
I
Q
G
I
K
F
I
R
E
Y
F
P
-
E
L
Y
I
I
C
D
V
C
L
C
E
Y
T
S
H
G
H
C
G
V
L
Y
D
D
G---
T
I
N
R
E
R
S
V
S
R
L
A
A
V
A
V
N
Y
A
K
A
G
A
H
C
V
A
P
S
D
M
I
D
G
R
I
R
D
I
K
R
G
L
I
N
A
N
L
-
A
H
K
-
T
F
V
L
S
Y
A
A
K
F
S
G
N
L
Y
G
P
F
R
-
D
A
A
C
--
S
A
P
-
S
-
N
---
G
D
R
K
C
Y
Q
L
P
P
A
G
R
G
L
A
R
R
A
L
E
R
D
M
S
E
G
A
D
G
I
I
V
K
P
S
T
F
Y
L
D
I
M
R
D
A
S
-
E
I
C
K
-
D
-
L
P
I
C
A
Y
H
V
S
G
E
Y
A
M
L
H
A
A
A
E
K
G
V
V
D
L
K
T
I
A
F
E
S
H
Q
G
F
L
R
A
G
A
R
L
I
I
T
Y
L
A
P
E
F
L
D
W
L
D
E
-
15
PsiBlast_PDB
75.98
42%
-17
- C7 -
-
1B4K
1
HEM2_PSEAE
A:
[11-330]
------
P
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
-
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
--
T
PV
E
---
K
--
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
-
E
L
G
I
I
T
D
V
A
L
D
P
F
T
T
H
G
Q
D
G
I
L
D
D
D
G---
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
I
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
-
D
A
V
G
SA
S
-
N
-
L
G
K
---
G
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
-
D
E
-
F
-
R
-
A
P
T
F
V
Y
Q
V
S
G
E
Y
-
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
------
20
PsiBlast_PDB
74.21
40%
-47
- C7 -
-
1E51
1
HEM2_HUMAN
A:
[24-328]
--------------------------
T
T
L
N
A
S
N
L
I
Y
P
I
F
V
T
D
V
P
D
D
I
Q
P
I
T
S
L
P
G
V
A
R
Y
G
V
K
-
R
L
E
E
M
L
R
P
L
V
E
E
G
L
R
C
V
L
I
F
G
---
V
--
P
--
S
---
R
VP
K
D
E
R
G
S
A
A
D
S
E
E
S
P
A
I
E
A
I
H
L
L
R
K
T
F
P
-
N
L
L
V
A
C
D
V
C
L
C
P
Y
T
S
H
G
H
C
G
L
L
S
--G---
A
F
R
A
E
E
S
R
Q
R
L
A
E
V
A
L
A
Y
A
K
A
G
C
Q
V
V
A
P
S
D
M
M
D
G
R
V
E
A
I
K
E
A
L
M
A
H
G
L
-
G
-
N
R
V
S
V
M
S
Y
S
A
K
F
A
S
C
F
Y
G
P
F
R
-
D
A
A
K
--
S
-
S
P
A
-
F
---
G
D
R
R
C
Y
Q
L
P
P
G
A
R
G
L
A
L
R
A
V
D
R
D
V
R
E
G
A
D
M
L
M
V
K
P
G
M
P
Y
L
D
I
V
R
E
V
K
D
K
H
-
P
-
D
-
L
P
L
A
V
Y
H
V
S
G
E
F
A
M
L
W
H
G
A
Q
A
G
A
F
D
L
K
A
A
V
L
E
A
M
T
A
F
R
R
A
G
A
D
I
I
I
T
Y
Y
T
P
Q
L
L
Q
W
L
K
--
49
PsiBlast_CBE
73.44
40%
-45
- C7 -
-
5HNR
1
HEM2_HUMAN
A:
[24-328]
--------------------------
T
T
L
N
A
S
N
L
I
Y
P
I
F
V
T
D
V
P
D
D
I
Q
P
I
T
S
L
P
G
V
A
R
Y
G
V
K
-
R
L
E
E
M
L
R
P
L
V
E
E
G
L
R
C
V
L
I
F
G
---
V
--
P
--
S
---
R
VP
K
D
E
R
G
S
A
A
D
S
E
E
S
P
A
I
E
A
I
H
L
L
R
K
T
F
P
-
N
L
L
V
A
C
D
V
C
L
C
P
Y
T
S
H
G
H
C
G
L
L
S
--G---
A
F
R
A
E
E
S
R
Q
R
L
A
E
V
A
L
A
Y
A
K
A
G
C
Q
V
V
A
P
S
D
M
M
D
G
R
V
E
A
I
K
E
A
L
M
A
H
G
L
-
G
-
N
R
V
S
V
M
S
Y
S
A
K
F
A
S
C
F
Y
G
P
F
R
-
D
A
A
K
--
S
-
S
P
A
-
F
---
G
D
R
R
C
Y
Q
L
P
P
G
A
R
G
L
A
L
R
A
V
D
R
D
V
R
E
G
A
D
M
L
M
V
K
P
G
M
P
Y
L
D
I
V
R
E
V
K
D
K
H
-
P
-
D
-
L
P
L
A
V
Y
H
V
S
G
E
F
A
M
L
W
H
G
A
Q
A
G
A
F
D
L
K
A
A
V
L
E
A
M
T
A
F
R
R
A
G
A
D
I
I
I
T
Y
Y
T
P
Q
L
L
Q
W
L
K
--
19
PsiBlast_PDB
71.79
40%
-108
- C7 -
-
1PV8
1
HEM2_HUMAN
A:
[24-329]
--------------------------
T
T
L
N
A
S
N
L
I
Y
P
I
F
V
T
D
V
P
D
D
I
Q
P
I
T
S
L
P
G
V
A
R
Y
G
V
K
-
R
L
E
E
M
L
R
P
L
V
E
E
G
L
R
C
V
L
I
F
G
---
V
--
P
-------------------
E
E
S
P
A
I
E
A
I
H
L
L
R
K
T
F
P
-
N
L
L
V
A
C
D
V
C
L
C
------------------
A
F
R
A
E
E
S
R
Q
R
L
A
E
V
A
L
A
Y
A
K
A
G
C
Q
V
V
A
P
S
D
--
D
G
R
V
E
A
I
K
E
A
L
M
A
H
G
L
-
G
-
N
R
V
S
V
M
S
Y
S
A
K
F
A
S
C
F
Y
G
P
F
R
-
D
A
A
--------------------
L
P
P
G
A
R
G
L
A
L
R
A
V
D
R
D
V
R
E
G
A
D
M
L
M
V
K
P
G
M
P
Y
L
D
I
V
R
E
V
K
D
K
H
-
P
-
D
-
L
P
L
A
V
Y
H
V
S
G
E
F
A
M
L
W
H
G
A
Q
A
G
A
F
D
L
K
A
A
V
L
E
A
M
T
A
F
R
R
A
G
A
D
I
I
I
T
Y
Y
T
P
Q
L
L
Q
W
L
K
E
-