@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLU2: (2017-11-04 )
MTDKSIKELALSVGRPVEKLLEQAREAGLPQRTADDIITTEQQDTLVNYLKKVHGQESGNTGKIALKRKTTSTAKVASTSGKAKTINVEVRKKQVFAKPNPEQIAAEAKARAEAEAKARAEQQAREAAEQKARLQTEQKAKATLDAMRAAHQQDSAAQSAPKAAVVVEKRGGGTVKPAPKPAETLEQKKAREAQTAQLKATEEAARRKAAEEAQQRTLEQMRKMASKYSNDDATATIRVIDDSPLASGLVGQAYEDSFNQEDREIKRGGATTNPRAGKKGGRRGQEEQSFVNHNKRGLKSSQANKHGFEKPVKKQVYDVEIGSSIVVADLAQKMAIKVREVIKTLMKMGELVNQNQTIDQDTAALVVEEMGHNPVLVSDTQAEDNLLEAAEEARGEQTTRPPVVTIMGHVDHGKTSLLDRIRRSKVAAGEAGGITQHIGAYHVETDKGIITFLDTPGHAAFTSMRARGAKATDIVVLVVAADDGVMPQTAEAIDHARAAGTPIIVAINKMDKESADPDRVLNELTTKEIVPEEWGGDVPVAKVSAHTGQGIDELLDLILIQSELMELKASAEGAAQGVVIEARVDKGRGAVTSILVQNGTLNIGDLVLAGSSYGRVRAMSDENGKPIKSAGPSIPVEILGLPEAPMAGDEVLVVNDEKKAREVADARADREREKRIERQSAMRLENIMASMGKKDVPTVNVVLRTDVRGTLEALNAALHELSTDEVKVRVISSGVGAITESDVILAESSEAVLLGFNVRADTAARQKSDQDGIDIRYYSIIYELIDDVKDAMSGKLAPEHRETILGVAQVREVFRSSKFGAAAGCMVMEGVIHRNKPIRVLRDDVVIFQGELESLRRYKDVVDEVRAGMECGLAVKGYNDIKPLDKIEVYDVQIVKRSL
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......-350..-.....360.......370.......380.......390.......400.-......410.......420.--......430.......440....------------------.------------------.------------------.---------..------------------450-------.......460.......470.......480.......490.......500-.......510-------------------------.-------------------...-.--------------------------.--------------------------.------------.520----------........530-----.------.------.------...-------------..540.......550.......------560-..-.---.---....570.......580.......590.......600...-....610---.----.......620--------.--------.-------------...--.--.--630-........640.......650.......660.......670-......----------.-----.680.------.---.----------------....--.690...--....700.......710.......720-.......730.......740......------.------750----.........760.......770.......780.......790.......800-..-----..------.....810---.--......---.820.......830.......840.......850.......860.......870.....-.----.880.......890.......--------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
D
K
S
I
K
E
L
A
L
SVG
R
P
V
E
K
L
L
E
Q
A
R
EAGLPQRTADDIITT
E
Q
Q
D
T
L
V
N
Y
L
K
K
V
HGQESGNT
G
K
I
A
L
K
RKTTS
T
A
K
V
ASTSGK
A
K
T
I
N
V
E
V
R
K
K
Q
VFAKP
N
P
E
Q
I
A
A
E
A
K
AR
A
E
A
E
A
K
A
R
A
E
Q
Q
A
R
E
A
A
E
Q
K
A
R
L
Q
T
E
Q
K
A
K
A
T
L
D
A
M
R
A
A
H
QQD
S
A
AQSAP
K
A
A
V
V
V
EKRGGGTVKPAPK
P
A
E
T
L
E
Q
K
K
AREA
Q
T
A
Q
L
K
A
T
E
E
A
A
R
R
K
A
A
E
E
A
Q
Q
R
T
L
E
Q
M
R
K
M
A
S
KYSNDDA
T
A
T
I
R
V
IDDSPLAS
G
L
V
G
Q
A
Y
EDSFNQ
E
D
R
E
I
KRGGATTNPRAGKKGGRRG
Q
E
E
Q
S
F
V
N
HNKRGLKSSQANKHGFEK
P
V
K
K
Q
V
Y
D
V
EIGSS
I
V
V
A
D
L
A
Q
K
M
A
I
K
V
R
E
V
I
K
T
L
M
K
M
G
-
E
L
VNQ-NQTI
D
Q
D
T
A
A
L
V
V
E
EMGHN
P
V
L
V
SDTQAE
D
N
L
L
E
A
A
E
E
ARGEQTTRP
P
V
-
V
T
I
M
GHVDH
G
K
T
S
L
L
D
R
I
R
R
--
S
KVAAGEAGGITQHI
G
A
--
Y
H
V
E------------------T------------------D------------------K---------
G
I
------------------
I
T
F
-------LDTPG
H
A
A
F
T
S
M
R
ARGAK
A
T
D
I
V
V
L
V
V
AADDGVMP
Q
T
A
E
A
I
D
H
ARAAG
T
P
-
I
I
V
A
I
NKMD--------------------------K-------------------ESA-
D
--------------------------
P
--------------------------
D
------------
R
V
L
-----------
N
E
L
T
T
K
EIV
P
------
E
------E------W------GGD-------------V
P
V
A
K
V
SAHTGQ
G
I
D
E
L
L
D
L
I
L
------
I
Q
--
S
E
-
L
---
M
---
E
L
K
ASAEGAAQ
G
V
V
I
E
A
R
VDKGRG
A
V
T
S
I
L
VQNGTLN
I
G
D
-
L
V
LAGS----S----YG
R
V
R
AMSDE--------N--------G-------------KPI--K--S--AG--PSI
P
V
E
I
LGLPEAPMAG
D
E
V
L
V
VN
D
E
K
K
A
R
E
V
A
D
A
RA
D
R
E
--
R
E
K
R
I
E
----------
R
-----
Q
S
A
-
M
------
R
---
L
----------------
E
N
I
M
--
A
S
MGKKD--V
P
T
V
N
V
V
L
RTDV
R
G
T
L
E
A
L
N
A
A
L
H
ELS-TD
E
V
K
V
R
V
I
SSGVGAITES
D
V
I
L
AES------S------
E
------
A
V
L
L
G
F
NVRADTAARQKSDQDG
I
D
I
R
Y
Y
S
I
I
Y
E
L
I
D
D
V
K
D
A
MSGKLA
P
E
H
---
R
E
-----
T
I
------
L
G
V
A
Q
V
R
----
E
--
V
F
RSSK---FGA
A
A
G
C
M
V
M
E
G
V
IHRNK
P
I
R
V
LRD
D
V
V
I
F
Q
G
E
L
E
S
L
R
R
Y
K
D
V
V
D
E
V
R
A
G
M
ECG
L
A
VKG-Y----NDIKPL
D
K
I
E
V
Y
D
V
Q
I
V
KRSL--------------------------
2
PsiBlast_PDB
80.83
49%
-103
- C5 -
-
5ME1
-
IF2_ECOLI
W:
[382-882]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
G
A
A
A
E
P
-
R
A
P
V
-
V
T
I
M
G
H
V
D
H
G
K
T
S
L
L
D
Y
I
R
S
--
T
K
V
A
S
G
E
A
G
G
I
T
Q
H
I
G
A
--
Y
H
V
E
------------------
T
------------------
E
------------------
N
---------
G
M
------------------
I
T
F
-------
L
D
T
P
G
H
A
A
F
T
S
M
R
A
R
G
A
Q
A
T
D
I
V
V
L
V
V
A
A
D
D
G
V
M
P
Q
T
I
E
A
I
Q
H
A
K
A
A
Q
V
P
-
V
V
V
A
V
N
K
I
D
--------------------------
K
-------------------
P
E
A
-
D
--------------------------
P
--------------------------
D
------------
R
V
K
-----------
N
E
L
S
Q
Y
G
I
L
P
------
E
------
E
------
W
------
G
G
E
-------------
S
Q
F
V
H
V
S
A
K
A
G
T
G
I
D
E
L
L
D
A
I
L
------
L
Q
--
A
E
-
V
---
L
---
E
L
K
A
V
R
K
G
M
A
S
G
A
V
I
E
S
F
L
D
K
G
R
G
P
V
A
T
V
L
V
R
E
G
T
L
H
K
G
D
-
I
V
L
C
G
F
----
E
----
Y
G
R
V
R
A
M
R
N
E
--------
L
--------
G
-------------
Q
E
V
--
L
--
E
--
A
G
--
P
S
I
P
V
E
I
L
G
L
S
G
V
P
A
A
G
D
E
V
T
V
V
R
D
E
K
K
A
R
E
V
A
L
Y
R
Q
G
K
F
--
R
E
V
K
L
A
----------
R
-----
Q
Q
K
-
S
------
K
---
L
----------------
E
N
M
F
--
A
N
M
T
E
G
E
--
V
H
E
V
N
I
V
L
K
A
D
V
Q
G
S
V
E
A
I
S
D
S
L
L
K
L
S
-
T
D
E
V
K
V
K
I
I
G
S
G
V
G
G
I
T
E
T
D
A
T
L
A
A
A
------
S
------
N
------
A
I
L
V
G
F
N
V
R
A
D
A
S
A
R
K
V
I
E
A
E
S
L
D
L
R
Y
Y
S
V
I
Y
N
L
I
D
E
V
K
A
A
M
S
G
M
L
S
P
E
L
---
K
Q
-----
Q
I
------
I
G
L
A
E
V
R
----
D
--
V
F
K
S
P
K
---
F
G
A
I
A
G
C
M
V
T
E
G
V
V
K
R
H
N
P
I
R
V
L
R
D
N
V
V
I
Y
E
G
E
L
E
S
L
R
R
F
K
D
D
V
N
E
V
R
N
G
M
E
C
G
I
G
V
K
N
-
Y
----
N
D
V
R
T
G
D
V
I
E
V
F
E
I
---------------------------------
1
PsiBlast_PDB
80.69
49%
-102
- C5 -
-
5ME0
-
IF2_ECOLI
W:
[382-882]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
G
A
A
A
E
P
-
R
A
P
V
-
V
T
I
M
G
H
V
D
H
G
K
T
S
L
L
D
Y
I
R
S
--
T
K
V
A
S
G
E
A
G
G
I
T
Q
H
I
G
A
--
Y
H
V
E
------------------
T
------------------
E
------------------
N
---------
G
M
------------------
I
T
F
-------
L
D
T
P
G
H
A
A
F
T
S
M
R
A
R
G
A
Q
A
T
D
I
V
V
L
V
V
A
A
D
D
G
V
M
P
Q
T
I
E
A
I
Q
H
A
K
A
A
Q
V
P
-
V
V
V
A
V
N
K
I
D
--------------------------
K
-------------------
P
E
A
-
D
--------------------------
P
--------------------------
D
------------
R
V
K
-----------
N
E
L
S
Q
Y
G
I
L
P
------
E
------
E
------
W
------
G
G
E
-------------
S
Q
F
V
H
V
S
A
K
A
G
T
G
I
D
E
L
L
D
A
I
L
------
L
Q
--
A
E
-
V
---
L
---
E
L
K
A
V
R
K
G
M
A
S
G
A
V
I
E
S
F
L
D
K
G
R
G
P
V
A
T
V
L
V
R
E
G
T
L
H
K
G
D
-
I
V
L
C
G
F
----
E
----
Y
G
R
V
R
A
M
R
N
E
--------
L
--------
G
-------------
Q
E
V
--
L
--
E
--
A
G
--
P
S
I
P
V
E
I
L
G
L
S
G
V
P
A
A
G
D
E
V
T
V
V
R
D
E
K
K
A
R
E
V
A
L
Y
R
Q
G
K
F
--
R
E
V
K
L
A
----------
R
-----
Q
Q
K
-
S
------
K
---
L
----------------
E
N
M
F
--
A
N
M
T
E
G
E
--
V
H
E
V
N
I
V
L
K
A
D
V
Q
G
S
V
E
A
I
S
D
S
L
L
K
L
S
-
T
D
E
V
K
V
K
I
I
G
S
G
V
G
G
I
T
E
T
D
A
T
L
A
A
A
------
S
------
N
------
A
I
L
V
G
F
N
V
R
A
D
A
S
A
R
K
V
I
E
A
E
S
L
D
L
R
Y
Y
S
V
I
Y
N
L
I
D
E
V
K
A
A
M
S
G
M
L
S
P
E
L
---
K
Q
-----
Q
I
------
I
G
L
A
E
V
R
----
D
--
V
F
K
S
P
K
---
F
G
A
I
A
G
C
M
V
T
E
G
V
V
K
R
H
N
P
I
R
V
L
R
D
N
V
V
I
Y
E
G
E
L
E
S
L
R
R
F
K
D
D
V
N
E
V
R
N
G
M
E
C
G
I
G
V
K
N
-
Y
----
N
D
V
R
T
G
D
V
I
E
V
F
E
I
---------------------------------
4
PsiBlast_PDB
71.61
41%
-58
- C3 -
-
3J4J
-
IF2_THET8
A:
[2-564]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
-
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
------
L
V
K
E
Q
R
G
L
Q
E
K
L
-
A
E
E
E
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
H
E
A
F
T
T
I
R
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
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V
I
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S
K
L
D
K
Q
A
G
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I
A
N
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Q
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F
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V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
--
K
A
R
E
E
E
----------
E
-----
K
A
R
-
A
------
P
---
A
----------------
T
M
A
A
--
L
L
A
A
M
A
E
EG
A
K
E
L
N
L
I
L
R
A
D
T
Q
G
S
L
E
A
I
Q
H
I
L
A
R
A
T
-
T
E
D
V
K
I
N
I
L
A
A
Q
V
G
A
P
T
E
S
D
V
L
L
A
Q
T
------
A
------
N
------
A
A
I
L
A
F
G
V
N
P
P
G
S
V
K
K
K
A
E
E
K
G
V
L
L
K
T
F
R
I
I
Y
D
L
V
D
E
V
R
N
M
V
K
G
A
R
E
P
Q
Y
---
K
E
-----
E
V
------
L
G
Q
A
E
V
R
----
A
--
I
F
R
L
P
T
---
G
K
Q
V
A
G
C
M
V
T
Q
G
R
I
P
R
N
A
E
V
R
V
L
R
D
G
Q
V
I
W
Q
G
R
I
A
S
L
K
R
F
K
E
D
V
R
E
V
A
Q
G
Y
E
C
G
I
G
L
D
G
-
F
----
D
D
F
R
E
G
D
V
I
E
A
F
-----------------------------------
128
HHSearch
70.50
42%
-4
- C3 -
-
3J4J
-
IF2_THET8
A:
[3-568]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
L
V
K
E
Q
R
------
G
L
Q
E
K
L
A
E
E
--
E
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
H
E
A
F
T
T
I
R
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
--
K
A
R
E
E
E
E
K
--------
A
-----
R
A
P
-
A
------
T
---
M
----------------
A
A
L
L
--
A
A
M
A
E
E
G
--
A
K
E
L
N
L
I
L
R
A
D
T
Q
G
S
L
E
A
I
Q
H
I
L
A
R
A
T
-
T
E
D
V
K
I
N
I
L
A
A
Q
V
G
A
P
T
E
S
D
V
L
L
A
Q
T
------
A
------
N
------
A
A
I
L
A
F
G
V
N
P
P
G
S
V
K
K
K
A
E
E
K
G
V
L
L
K
T
F
R
I
I
Y
D
L
V
D
E
V
R
N
M
V
K
G
A
R
E
P
Q
Y
---
K
E
-----
E
V
------
L
G
Q
A
E
V
R
----
A
--
I
F
R
L
P
T
---
G
K
Q
V
A
G
C
M
V
T
Q
G
R
I
P
R
N
A
E
V
R
V
L
R
D
G
Q
V
I
W
Q
G
R
I
A
S
L
K
R
F
K
E
D
V
R
E
V
A
Q
G
Y
E
C
G
I
G
L
D
G
-
F
----
D
D
F
R
E
G
D
V
I
E
A
F
Q
M
V
E
-------------------------------
9
PsiBlast_PDB
69.69
46%
-111
- C5 -
-
4B44
1
IF2_THET8
A:
[2-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
-
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
------
L
V
K
E
Q
R
G
L
Q
E
K
L
-
A
E
E
E
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
H
E
A
------
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.05
46%
-108
- C5 -
-
4B47
1
IF2_THET8
A:
[2-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
-
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
------
L
V
K
E
Q
R
G
L
Q
E
K
L
-
A
E
E
E
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
H
E
------
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
68.00
46%
-107
- C5 -
-
4B48
1
IF2_THET8
A:
[2-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
-
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
------
L
V
K
E
Q
R
G
L
Q
E
K
L
-
A
E
E
E
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
H
E
A
------
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.79
41%
-66
- C5 -
-
4KJZ
1
IF2_THET8
A:
[2-469]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
C
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
-
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
------
L
V
K
E
Q
R
G
L
Q
E
K
L
-
A
E
E
E
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
------
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
-----------
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
P
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
--
K
A
R
E
E
E
----------
E
KARRP
R
T
M
-
A
------
E
---
L
----------------
L
R
A
M
--
Q
E
E
G
R
K
E
-----
L
N
L
I
L
R
A
D
T
Q
G
S
L
E
A
I
Q
H
I
L
A
R
E
S
-
T
E
D
V
K
I
N
I
L
L
A
Q
V
G
A
P
T
E
S
D
V
L
L
A
Q
T
------
A
------
N
------
A
A
I
L
A
F
G
V
N
P
P
G
S
V
K
K
K
A
E
E
K
G
V
L
L
K
T
F
R
I
I
Y
D
L
V
D
E
V
R
N
M
V
K
G
Q
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
66.12
64%
-46
- C7 -
-
1ZO1
-
IF2_ECOLI
I:
[225-724]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
A
P
V
-
V
T
I
M
G
H
V
D
H
G
K
T
S
L
L
E
Y
I
R
S
--
T
K
V
A
S
G
E
A
G
G
I
T
Q
H
I
G
A
--
Y
H
V
E
------------------
T
------------------
E
------------------
N
---------
G
M
------------------
I
T
F
-------
L
D
T
P
G
H
A
A
F
T
S
M
R
A
R
G
A
Q
A
T
D
I
V
V
L
V
V
A
A
D
D
G
V
M
P
Q
T
I
E
A
I
Q
H
A
K
A
A
Q
V
P
-
V
V
V
A
V
N
K
I
D
--------------------------
K
-------------------
P
E
A
-
D
--------------------------
P
--------------------------
D
------------
R
V
K
-----------
N
E
L
S
Q
Y
G
I
L
P
------
E
------
E
------
W
------
G
G
E
-------------
S
Q
F
V
H
V
S
A
K
A
G
T
G
I
D
E
L
L
D
A
I
L
------
L
Q
--
A
E
-
V
---
L
---
E
L
K
A
V
R
K
G
M
A
S
G
A
V
I
E
S
F
L
D
K
G
R
G
P
V
A
T
V
L
V
R
E
G
T
L
H
K
G
D
-
I
V
L
C
G
F
----
E
----
Y
G
R
V
R
A
M
R
N
E
--------
L
--------
G
-------------
Q
E
V
--
L
--
E
--
A
G
--
P
S
I
P
V
E
I
L
G
L
S
G
V
P
A
A
G
D
E
V
T
V
V
R
D
E
K
K
A
R
E
V
A
L
Y
R
Q
G
K
F
--
R
E
V
K
L
A
----------
R
-----
Q
Q
K
-
S
------
K
---
L
----------------
E
N
M
F
--
A
N
M
T
E
G
E
--
V
H
E
V
N
I
V
L
K
A
D
V
Q
G
S
V
E
A
I
S
D
S
L
L
K
L
S
-
T
D
E
V
K
V
K
I
I
G
S
G
V
G
G
I
T
E
T
D
A
T
L
A
A
A
------
S
------
N
------
A
I
L
V
G
F
N
V
R
A
D
A
S
A
R
K
V
I
E
A
E
S
L
D
L
R
Y
Y
S
V
I
Y
N
L
I
D
E
V
K
A
A
M
S
G
M
L
S
P
E
L
---
K
Q
-----
Q
I
------
I
G
L
A
E
V
R
----
D
--
V
F
K
S
P
K
---
F
G
A
I
A
G
C
M
V
T
E
G
V
V
K
R
H
N
P
I
R
V
L
R
D
N
V
V
I
Y
E
G
E
L
E
S
L
R
R
F
K
D
D
V
N
E
V
R
N
G
M
E
C
G
I
G
V
K
N
-
Y
----
N
D
V
R
T
G
D
V
I
E
V
F
E
I
I
E
I
Q
R
T
---------------------------
10
PsiBlast_PDB
65.41
46%
-99
- C5 -
-
4B3X
3
IF2_THET8
A:
[2-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
-
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
------
L
V
K
E
Q
R
G
L
Q
E
K
L
-
A
E
E
E
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
G
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
H
E
A
F
T
T
I
R
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
64.92
45%
-109
- C5 -
-
4B43
4
IF2_THET8
A:
[2-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
-
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
------
L
V
K
E
Q
R
G
L
Q
E
K
L
-
A
E
E
E
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
L
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
A
E
A
---------
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
64.47
41%
-69
- C5 -
-
4KJZ
1
IF2_THET8
C:
[2-473]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
C
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
-
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
------
L
V
K
E
Q
R
G
L
Q
E
K
L
-
A
E
E
E
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
H
----------
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
P
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
--
K
A
R
E
E
E
----------
E
K
A
R
RP
R
T
M
-
A
------
E
---
L
----------------
L
R
A
M
--
Q
E
E
G
R
K
E
-----
L
N
L
I
L
R
A
D
T
Q
G
S
L
E
A
I
Q
H
I
L
A
R
E
S
-----
K
I
N
I
L
L
A
Q
V
G
A
P
T
E
S
D
V
L
L
A
Q
T
------
A
------
N
------
A
A
I
L
A
F
G
V
N
P
P
G
S
V
K
K
K
A
E
E
K
G
V
L
L
K
T
F
R
I
I
Y
D
L
V
D
E
V
R
N
M
V
K
G
Q
R
E
P
Q
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.63
64%
-46
* C7 *
-
1ZO1
-
IF2_ECOLI
I:
[226-724]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
P
V
-
V
T
I
M
G
H
V
D
H
G
K
T
S
L
L
E
Y
I
R
S
--
T
K
V
A
S
G
E
A
G
G
I
T
Q
H
I
G
A
--
Y
H
V
E
------------------
T
------------------
E
------------------
N
---------
G
M
------------------
I
T
F
-------
L
D
T
P
G
H
A
A
F
T
S
M
R
A
R
G
A
Q
A
T
D
I
V
V
L
V
V
A
A
D
D
G
V
M
P
Q
T
I
E
A
I
Q
H
A
K
A
A
Q
V
P
-
V
V
V
A
V
N
K
I
D
--------------------------
K
-------------------
P
E
A
-
D
--------------------------
P
--------------------------
D
------------
R
V
K
-----------
N
E
L
S
Q
Y
G
I
L
P
------
E
------
E
------
W
------
G
G
E
-------------
S
Q
F
V
H
V
S
A
K
A
G
T
G
I
D
E
L
L
D
A
I
L
------
L
Q
--
A
E
-
V
---
L
---
E
L
K
A
V
R
K
G
M
A
S
G
A
V
I
E
S
F
L
D
K
G
R
G
P
V
A
T
V
L
V
R
E
G
T
L
H
K
G
D
-
I
V
L
C
G
F
----
E
----
Y
G
R
V
R
A
M
R
N
E
--------
L
--------
G
-------------
Q
E
V
--
L
--
E
--
A
G
--
P
S
I
P
V
E
I
L
G
L
S
G
V
P
A
A
G
D
E
V
T
V
V
R
D
E
K
K
A
R
E
V
A
L
Y
R
Q
G
K
F
--
R
E
V
K
L
A
----------
R
-----
Q
Q
K
-
S
------
K
---
L
----------------
E
N
M
F
--
A
N
M
T
E
G
E
--
V
H
E
V
N
I
V
L
K
A
D
V
Q
G
S
V
E
A
I
S
D
S
L
L
K
L
S
-
T
D
E
V
K
V
K
I
I
G
S
G
V
G
G
I
T
E
T
D
A
T
L
A
A
A
------
S
------
N
------
A
I
L
V
G
F
N
V
R
A
D
A
S
A
R
K
V
I
E
A
E
S
L
D
L
R
Y
Y
S
V
I
Y
N
L
I
D
E
V
K
A
A
M
S
G
M
L
S
P
E
L
---
K
Q
-----
Q
I
------
I
G
L
A
E
V
R
----
D
--
V
F
K
S
P
K
---
F
G
A
I
A
G
C
M
V
T
E
G
V
V
K
R
H
N
P
I
R
V
L
R
D
N
V
V
I
Y
E
G
E
L
E
S
L
R
R
F
K
D
D
V
N
E
V
R
N
G
M
E
C
G
I
G
V
K
N
-
Y
----
N
D
V
R
T
G
D
V
I
E
V
F
E
I
I
E
I
Q
R
T
---------------------------
137
HHSearch
59.86
33%
-1
* C3 *
-
4N3S
1
IF2P_YEAST
B:
[6-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
L
R
S
P
I
-
C
C
I
L
G
H
------
K
L
L
D
K
I
R
Q
--
T
N
V
Q
G
G
----
I
T
Q
Q
I
G
A
--
T
Y
F
P
------------------
I
------------------
D
A
I
K
A
K
T
K
VMAEY
E
K
Q
T
F
D
V
---------
P
G
------------------
L
L
V
-------
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
I
D
I
M
H
G
L
E
Q
Q
T
I
E
S
I
K
L
L
R
D
R
K
A
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
-------------------
L
Y
D
-
W
KAIPNNS
F
R
D
S
F
A
K
QS
R
A
V
Q
E
E
F
Q
S
R
Y
--------------------------
S
------------
K
I
Q
-----------
L
E
L
A
E
Q
G
L
N
S
------
E
------
L
------
Y
FQNKNM
S
K
Y
-------------
V
S
I
V
P
T
S
A
V
T
G
E
G
V
P
D
L
L
W
L
L
L
------
E
L
--
T
Q
-
K
R--
M
---
S
K
Q
L
M
Y
L
S
H
V
E
A
T
I
L
E
V
K
V
V
E
G
F
G
T
T
I
D
V
I
L
S
N
G
Y
L
R
E
G
D
-
R
I
V
L
C
G
MN
G
P
I
----
V
T
N
I
R
A
L
L
T
P
--------
Q
--------
P
L
R
E
L
R
L
K
SE
Y
V
H
H
K
E
V
--
K
--
A
--
A
L
---
G
V
K
I
A
A
N
D
L
E
K
-
A
V
S
G
S
R
L
L
V
V
G
P
E
D
D
E
D
E
L
M
D
D
V
M
D
-------------------------------------
D
---
L
----------------
T
G
L
L
--
D
S
V
--
D
---
T
T
G
K
G
V
V
V
Q
A
S
T
L
G
S
L
E
A
L
L
D
F
L
K
D
M
------
K
I
P
V
M
S
I
G
L
G
P
V
Y
K
R
D
V
M
K
A
S
T
MLEKAP
E
------
Y
------
A
V
M
L
C
F
D
V
K
V
D
K
E
A
E
Q
Y
A
E
Q
E
G
I
K
I
F
N
A
D
V
I
Y
H
L
F
D
S
F
T
A
Y
Q
E
K
L
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Fugue
58.70
44%
-15
- C5 -
-
4B3X
3
IF2_THET8
A:
[1-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
V
A
Y
K
S
H
-
A
S
T
L
E
E
K
D
A
E
A
V
R
E
L
V
K
E
Q
R
G
L
Q
E
K
L
A
E
E
E
R
--------
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
G
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
H
E
A
F
T
T
I
R
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
--
K
A
R
E
E
E
----------
E
-----
K
A
---------
R
---
R
----------------
P
R
T
M
--
A
E
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
58.36
33%
22
- C3 -
-
5FG3
1
IF2P_AERPE
A:
[13-568]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
R
Q
P
I
-
V
V
V
L
G
H
V
D
H
G
K
T
T
L
L
D
K
I
R
R
--
T
A
V
A
A
K
E
A
G
G
I
T
Q
H
I
G
A
--
S
I
V
P
------------------
A
------------------
D
V
I
E
K
I
A
E
PLKKV
I
P
V
K
L
V
I
---------
P
G
------------------
L
L
F
-------
I
D
T
P
G
H
E
L
F
S
N
L
R
R
R
G
G
S
V
A
D
F
A
I
L
V
V
D
I
M
E
G
F
K
P
Q
T
Y
E
A
L
E
L
L
K
E
R
R
V
P
-
F
L
I
A
A
N
K
I
D
--------------------------
R
-------------------
I
P
G
W
K
--------------------------
P
NP------------------------
D
AP
F
I
E
T
I
R
R
QD
P
K
V
R
E
I
L
E
Q
R
V
Y
E
I
V
G
K
M
Y
E
A
G
L
P
A
E
LFTRI
K
------
D
------
F
------
R
R
K
-------------
I
A
I
V
P
V
S
A
R
T
G
E
G
I
P
E
L
L
A
V
L
A
------
G
L
T
Q
T
Y
-
L
---
K
---
E
R
L
R
Y
A
E
G
P
A
K
G
V
V
L
E
V
K
E
M
Q
G
F
G
T
V
V
D
A
V
I
Y
D
G
V
L
K
K
E
D
-
I
I
V
V
G
G
----
R
E
G
P
I
V
T
R
V
R
A
L
L
M
P
--------
A
--------
P
LQDIRSREA
R
F
--
V
Q
V
--
D
--
R
VY
A
A
--
A
G
V
R
I
A
A
P
G
L
D
D
V
-
I
A
G
S
P
I
Y
A
A
E
S
E
E
E
A
R
K
L
M
E
A
V
Q
R
E
----------------------------------------
I
----------------
E
E
------
L
R
F
R
---
T
E
N
I
G
V
V
V
K
A
D
T
L
G
T
L
E
A
L
V
E
A
L
R
R
R
------
G
V
P
V
R
L
A
D
I
G
P
V
S
R
S
D
V
L
D
A
A
V
------
T
------
R
K
I
DPYL
G
V
V
L
A
F
N
V
K
V
L
P
E
A
E
E
E
A
S
R
A
G
V
K
I
F
R
E
S
M
I
Y
K
L
I
E
D
Y
E
E
W
V
K
K
E
K
E
A
E
R
---
L
K
A
L
N
SL
I
R
------
P
G
K
F
R
I
L
----
P
GY
V
F
R
R
S
D
----
P
A
I
V
G
V
E
V
L
G
G
V
I
R
P
G
Y
P
V
M
D
S
Q
G
-
R
--
E
L
G
R
I
M
A
I
K
D
R
D
R
S
L
E
E
A
R
L
G
A
A
V
A
V
S
I
Q
G
-
R
ILIG
R
H
A
N
E
G
D
I
L
Y
T
N
V
P
A
Q
H
------------------------------
138
HHSearch
57.45
45%
-29
- C5 -
-
4B43
4
IF2_THET8
A:
[3-354]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
-
V
A
Y
K
S
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
L
V
K
E
Q
R
G
L
Q
------
E
K
L
A
-
E
E
E
-
R
R
K
S
L
P
R
R
P
P
V
-
V
V
I
M
G
H
V
D
H
G
L
T
T
L
L
D
Y
L
R
K
--
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
--
F
E
V
K
------------------
T
------------------
P
------------------
Q
---------
G
T
------------------
V
V
F
-------
I
D
T
P
G
A
E
A
---------
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
-
L
I
F
A
I
N
K
I
D
--------------------------
L
-------------------
P
Q
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
------
Y
------
G
G
D
-------------
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
------
L
L
--
A
E
-
L
---
E
---
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
-
Y
V
V
A
G
E
----
A
----
Y
G
R
I
R
A
M
M
D
A
--------
D
--------
G
-------------
N
Q
R
--
K
--
E
--
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
K
A
R
E
E
E
E
K
----------
A
-----
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Fugue
56.15
28%
16
- C3 -
-
1G7S
1
IF2P_METTH
A:
[1-587]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
R
S
P
I
-
V
S
V
L
G
H
V
D
H
G
K
T
T
L
L
D
H
I
R
G
--
S
A
V
A
----
S
R
I
T
Q
H
I
G
A
--
T
E
I
P
------------------
M
------------------
D
------------------
V
---------
I
E
G
I
C
GDFLKKFSIRETLP
G
L
F
F
-------
I
D
T
P
G
H
E
A
F
T
T
L
R
K
R
G
G
A
L
A
D
L
A
I
L
I
V
D
I
N
E
G
F
K
P
Q
T
Q
E
A
L
N
I
L
R
M
Y
R
T
P
-
F
V
V
A
A
N
K
I
D
RIHGWRVHEGRP
F
M
E
T
F
S
K
QD
I
Q
V
Q
Q
K
-------------------
L
D
T
-
K
--------------------------
V
--------------------------
Y
------------
E
L
V
-----------
G
K
L
H
E
E
G
F
E
S
------
E
RFDRVT
D
------
F
------
A
S
Q
-------------
V
S
I
I
P
I
S
A
I
T
G
E
G
I
P
E
L
L
T
M
L
M
------
G
L
--
A
Q
-
Q
---
Y
LRE
Q
L
K
I
E
E
D
S
P
A
R
G
T
I
L
E
V
K
E
E
T
G
L
G
M
T
I
D
A
V
I
Y
D
G
I
L
R
K
D
D
-
T
I
A
M
M
T
----
S
K
D
V
I
S
T
R
I
R
S
L
L
K
P
--------
R
--------
P
LESRKK
F
Q
K
----
V
D
E
--
V
--
V
--
A
A
--
A
G
I
K
I
V
A
P
G
I
D
D
V
M
-
A
G
S
P
L
R
V
V
T
D
P
E
K
V
R
E
E
I
L
S
E
I
E
D
------------------------------------------------------------------
I
K
I
D
--
T
D
E
A
G
V
V
V
K
A
D
T
L
G
S
L
E
A
V
V
K
I
L
R
D
------
M
Y
V
P
I
K
V
A
D
I
G
D
V
S
R
R
D
V
V
N
A
G
I
------
A
------
L
Q
E
DRVY
G
A
I
I
A
F
N
V
K
V
I
P
S
A
A
Q
E
L
K
N
S
D
I
K
L
F
Q
G
N
V
I
Y
R
L
M
E
E
Y
E
E
W
V
R
G
I
E
E
E
K
K
---
K
K
-----
W
M
E
A
I
I
K
P
A
S
I
R
L
I
P
----
K
--
L
V
F
R
Q
S
---
K
P
A
I
G
G
V
E
V
L
T
G
V
I
R
Q
G
Y
P
L
M
N
D
D
G
E
T
V
---
G
T
V
E
S
M
Q
D
K
G
E
N
L
K
S
A
S
R
G
Q
K
V
A
M
A
I
K
D
-
A
VYG-
K
T
I
H
E
G
D
T
L
Y
V
D
I
P
E
N
H
Y
H
I
L
KEQLLT
D
E
E
L
D
L
M
D
K
I
A
E
I
K
R
K
KNPD
130
HHSearch
55.56
44%
9
- C3 -
-
3IZY
-
IF2M_BOVIN
P:
[178-713]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
S
P
V
-
V
T
I
M
G
H
V
D
H
G
K
T
T
L
L
D
K
L
R
K
--
T
Q
V
A
A
M
E
A
G
G
I
T
Q
H
I
G
A
--
F
L
V
S
------------------
L
------------------
P
S-----------------
G
---------
E
K
------------------
I
T
F
-------
L
D
T
P
G
H
A
A
F
S
A
M
R
A
R
G
T
Q
V
T
D
I
V
I
L
V
V
A
A
D
D
G
V
M
K
Q
T
V
E
S
I
Q
H
A
K
D
A
H
V
P
-
I
V
L
A
I
N
K
C
D
--------------------------
K
-------------------
A
E
A
-
D
--------------------------
P
--------------------------
E
------------
K
V
K
-----------
K
E
L
L
A
Y
D
V
V
C
------
E
------
D
------
Y
------
G
G
D
-------------
V
Q
A
V
H
V
S
A
L
T
G
E
N
M
M
A
L
A
E
A
T
I
------
A
L
--
A
E
-
M
---
L
---
E
L
K
A
D
P
T
G
A
V
E
G
T
V
I
E
S
F
T
D
K
G
R
G
P
V
T
T
A
I
I
Q
R
G
T
L
R
K
G
S
-
I
L
V
A
G
K
----
S
----
W
A
K
V
R
L
M
F
D
E
--------
N
--------
G
-------------
R
A
V
--
N
--
E
--
A
Y
--
P
S
M
P
V
G
I
I
G
W
R
D
L
P
S
A
G
D
E
I
L
E
V
E
S
E
P
R
A
R
E
V
V
D
W
R
K
Y
E
Q
--
E
Q
E
K
N
K
EDLKLIEEKR
K
-----
E
H
Q
E
A
HRKDRE
K
YGT
V
HWKERSYIKYREKRQQ
Q
P
L
K
PK
E
K
L
E
R
D
---
S
N
V
L
P
V
I
V
K
G
D
V
D
G
S
V
E
A
I
L
N
V
M
D
T
Y
D
A
S
H
E
C
E
L
D
L
V
H
F
G
V
G
D
I
S
E
N
D
V
N
L
A
E
T
------
F
------
H
------
G
V
I
Y
G
F
N
V
N
A
G
N
V
I
Q
Q
L
A
A
K
K
G
V
K
I
K
L
H
K
I
I
Y
R
L
I
E
D
L
Q
E
E
L
S
S
R
L
P
C
I
V
---
E
E
-----
H
P
------
I
G
E
A
S
I
L
----
A
--
T
F
S
I
T
E
GKK
K
V
P
V
A
G
C
R
V
Q
K
G
Q
I
E
K
Q
K
K
F
K
L
I
R
N
G
H
V
I
W
K
G
S
L
I
S
L
K
H
H
K
D
D
T
S
V
V
K
T
G
M
D
C
G
L
S
L
D
E
E
K
----
I
E
F
K
V
G
D
A
I
I
C
Y
E
----------------------------------
133
HHSearch
55.05
31%
15
- C3 -
-
1G7S
1
IF2P_METTH
A:
[2-558]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
S
P
I
-
V
S
V
L
G
H
V
D
H
G
K
T
T
L
L
D
H
I
R
G
--
S
A
V
A
S
R
----
I
T
Q
H
I
G
A
--
T
E
I
P
------------------
M
------------------
D
V
I
E
G
I
C
GDFLKKFSIRET
L
---------
P
G
------------------
L
F
F
-------
I
D
T
P
G
H
E
A
F
T
T
L
R
K
R
G
G
A
L
A
D
L
A
I
L
I
V
D
I
N
E
G
F
K
P
Q
T
Q
E
A
L
N
I
L
R
M
Y
R
T
P
-
F
V
V
A
A
N
K
I
D
--------------------------
R
-------------------
I
H
G
-
W
--------------------------
R
VHEGRP
F
M
E
T
F
S
K
QD
I
Q
V
Q
Q
K
L
D
T
K
V
Y
------------
E
L
V
-----------
G
K
L
H
E
E
G
F
E
S
------
E
RFDRVT
D
------
F
------
A
S
Q
-------------
V
S
I
I
P
I
S
A
I
T
G
E
G
I
P
E
L
L
T
M
L
M
------
G
L
--
A
Q
-
Q
YLR
E
---
Q
L
K
I
E
E
D
S
P
A
R
G
T
I
L
E
V
K
E
E
T
G
L
G
M
T
I
D
A
V
I
Y
D
G
I
L
R
K
D
D
-
T
I
A
M
M
T
----
S
K
D
V
I
S
T
R
I
R
S
L
L
K
P
--------
R
--------
P
LESRKK
F
------
Q
K
V
--
D
--
E
--
V
V
AA
A
G
I
K
I
V
A
P
G
I
D
D
V
-
M
A
G
S
P
L
R
V
V
T
D
P
E
K
V
R
E
E
I
L
S
----------------------------------------
E
---
I
----------------
E
------
D
I
K
I
D
---
T
D
E
A
G
V
V
V
K
A
D
T
L
G
S
L
E
A
V
V
K
I
L
R
D
M
------
Y
V
P
I
K
V
A
D
I
G
D
V
S
R
R
D
V
V
N
A
G
I
------
A
L
Q
E
DRV
Y
------
G
A
I
I
A
F
N
V
K
V
I
P
S
A
A
Q
E
L
K
N
S
D
I
K
L
F
Q
G
N
V
I
Y
R
L
M
E
E
Y
E
E
W
V
R
G
I
E
E
E
K
K
K
K
W
M
E
-----
A
I
------
I
K
P
A
S
I
R
LIPK
L
--
V
F
R
Q
S
K
----
P
A
I
G
G
V
E
V
L
T
G
V
I
R
Q
G
Y
P
L
M
N
-
D
D
G
E
T
V
--
G
T
V
E
S
M
Q
D
K
G
E
N
L
K
S
A
S
R
G
Q
K
V
A
M
A
I
K
D
-
A
VYG-
K
T
I
H
E
G
D
T
L
Y
V
D
I
P
E
N
H
Y
-----------------------------
13
PsiBlast_PDB
55.04
70%
-132
- C5 -
-
2LKD
1
A:
[7-177]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
P
V
-
V
T
I
M
G
H
V
D
H
G
K
T
T
L
L
D
A
I
R
H
--
S
K
V
T
E
Q
E
A
G
G
I
T
Q
H
I
G
A
--
Y
Q
V
T
------------------
V
------------------
N
------------------
D
---------
K
K
------------------
I
T
F
-------
L
D
T
P
G
H
E
A
F
T
T
M
R
A
R
G
A
Q
V
T
D
I
V
I
L
V
V
A
A
D
D
G
V
M
P
Q
T
V
E
A
I
N
H
A
K
A
A
N
V
P
-
I
I
V
A
I
N
K
M
D
--------------------------
K
-------------------
P
E
A
-
N
--------------------------
P
--------------------------
D
------------
R
V
M
-----------
Q
E
L
M
E
Y
N
L
V
P
------
E
------
E
------
W
------
G
G
D
-------------
T
I
F
C
K
L
S
A
K
T
K
E
G
L
D
H
L
L
E
M
I
L
------
L
V
--
S
E
-
M
---
E
---
E
L
K
A
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
HHSearch
47.42
34%
-5
- C5 -
-
4TMX
8
IF2P_CHATD
A:
[5-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
N
L
R
S
P
I
-
C
C
I
L
G
H
V
N
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
--
T
Y
F
P
------------------
V
E
A
I
K
Q
K
T
AVVNKDGKFEF
K
------------------
V
---------
P
G
------------------
L
L
I
-------
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
-------------------
L
Y
G
-
W
--------------------------
K
K
I
E
NNG
F
R
E
S
F
A
L
QN
K
A
V
Q
-------
N
E
F
R
N
R
L
D
-----
Q
V
K
-----------
L
Q
F
A
E
Q
G
F
N
S
------
E
------
L
------
F
YENKNF
A
R
Y
-------------
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
------
Q
L
--
C
Q
E
R
---
M
---
A
S
S
L
M
Y
L
S
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
-
R
I
V
L
C
G
LE
G
P
I
----
K
T
N
I
R
A
L
L
T
P
APMRELRI
K
--------
G
-------------
Q
Y
I
H
H
K
EV
K
--
A
A
--
Q
G
V
K
I
S
A
P
G
L
E
G
A
-
I
A
G
S
R
L
L
V
V
G
P
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
HHSearch
47.27
35%
-6
- C5 -
-
4TMW
1
B:
[5-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
N
L
R
S
P
I
-
C
C
I
L
G
H
V
D
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
--
T
Y
F
P
V
E
A
I
K
Q
K
T
AVVNKDGK
F
E
F
------------------
K
------------------
V
---------
P
G
------------------
L
L
I
-------
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
-------------------
L
Y
G
-
W
--------------------------
K
K
I
E
NNG
F
R
E
S
F
A
L
QN
K
A
V
Q
-------
N
E
F
R
N
R
L
D
-----
Q
V
K
-----------
L
Q
F
A
E
Q
G
F
N
S
------
E
------
L
FYENKN
F
------
A
R
Y
-------------
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
------
Q
L
--
C
Q
E
R
---
M
---
A
S
S
L
M
Y
L
S
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
-
R
I
V
L
C
G
----
L
E
G
P
I
K
T
N
I
R
A
L
L
T
P
--------
A
PMRELR
I
K
G
-------------
Q
Y
I
H
H
K
EV
K
--
A
A
--
Q
G
V
K
I
S
A
P
G
L
E
G
A
-
I
A
G
S
R
L
L
V
V
G
P
D
D
D
E
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
38.34
33%
4
- C5 -
-
4TN1
1
IF2P_CHATD
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
R
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYG
W
K
K
I
E
NNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
37.81
33%
4
- C5 -
-
4TMZ
1
IF2P_CHATD
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
D
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYG
W
K
K
I
E
NNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
37.57
33%
3
- C5 -
-
4TMZ
2
B:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
D
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
TY
F
P
V
E
------------------
A
------------------
I
------------------
K
QKTAVVNKD
G
K
------------------
F
E
F
KVPGLLI
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYGWKKIENNGFRESFALQ
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
SELFYENKNFARY
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
QLCQER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
37.43
33%
4
- C5 -
-
4TMV
4
B:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
D
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYG
W
K
K
I
E
NNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
37.33
33%
8
- C5 -
-
4TMW
1
IF2P_CHATD
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
D
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYGWKKIENNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
37.22
33%
-1
- C5 -
-
4TMT
8
B:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
A
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYG
W
K
K
I
E
NNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNF
A
R
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
37.03
33%
7
- C5 -
-
4TMV
3
IF2P_CHATD
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
D
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYGWKKIENNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
36.94
33%
5
- C5 -
-
4TMT
7
IF2P_CHATD
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
A
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYG
W
K
K
I
E
NNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
36.69
33%
3
- C5 -
-
4TMX
9
B:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
N
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYG
W
K
K
I
E
NNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
36.48
33%
5
- C5 -
-
4TMX
7
IF2P_CHATD
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
N
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYG
W
K
K
I
E
NNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
36.26
33%
-0
- C5 -
-
4TN1
1
B:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
R
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
KVP
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYGWKKIENNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
35.99
33%
3
- C5 -
-
4TMW
1
B:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
P
I
-
C
C
I
L
G
H
V
D
T
G
K
T
K
L
L
D
K
I
R
Q
--
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
Y
F
P
V
E
------------------
A
------------------
I
------------------
K
Q
K
T
AVVNKD
G
K
------------------
F
E
F
K
V
P
G
L
L
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
-
F
V
V
A
L
N
K
I
D
--------------------------
R
LYG
W
K
K
I
E
NNG
F
R
E
S
F
A
L
Q
N
K
A
-
V
--------------------------
Q
--------------------------
N
------------
E
F
R
-----------
N
R
L
D
Q
V
K
L
Q
F
------
A
------
E
------
Q
------
G
F
N
S
E
LFYENKNFAR
Y
V
S
L
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
V
Q
L
C
Q
ER
M
A
--
S
S
-
L
---
M
---
Y
L
S
-----
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
15.95
40%
-
- C5 -
-
1EFM
1
EFTU2_ECOLI
A:
[12-160]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
V
G
T
I
G
H
V
D
H
G
K
T
T
L
T
A
A
I
T
T
V
L
A
K
T
Y
-------
T
--
I
N
T
--
S
H
V
E
------------------
Y
------------------
D
------------------
T
---------
P
T
------------------
R
H
Y
A
H
-----
V
D
C
P
G
H
A
D
Y
V
K
N
M
I
T
G
A
A
Q
M
D
G
A
I
L
V
V
A
A
T
D
G
P
M
P
Q
T
R
E
H
I
L
L
G
R
Q
V
G
V
P
Y
I
I
V
F
L
N
K
C
D
--------------------------
M
-------------------
V
D
D
-
E
--------------------------
E
--------------------------
L
------------
L
E
L
-----------
V
E
M
E
V
R
E
L
L
S
------
Q
------
Y
DF----
P
------
G
D
D
-------------
T
P
I
V
R
G
S
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------