@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLZ6: (2017-11-05 )
MAYSYTEKKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQDGKSPKNREDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDVRECILRGSTYAAPMRVKIRLIIKDRETKSIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKTHSSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQILNLFYEKLPVYLDMGSYQIDLVPERLRGEMAQFDITDNEGKVIVEQGKRINARHVRQMEAAGLTKLSVPDEYLYERITAEDITLRDGEVIAANTLLSHEVMVKLAEGGVKQFNILFTNDIDRGSFVADTLRADLTRDREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKFNRRLGRPYEVGTDQKSREVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDDVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVARDSGVCVIANRGGVIEYVDASRIVIRVNEDEMVAGEAGVDIYNLIKYTRSNQNTCINQNVIVNLGDKVARGDILADGPSTDMGELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGLEKDDRALAIEKAQLDSYRKDLKEEYKIFEEAARERVIRLLKGQESNGGGSTKRGDKLSEDLLSGLELVDLLEIQPADEAIAERLTQIQVFLKEKSAEIDEKFAEKKRKLATGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILETHLGMAAKGLGDKIEKMLKEQRTVLELREFLDKIYNKVGGEQEDLDSLTDEEILALAGNLRAGVPLATPVFDGAEESQIKDLLELADISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIELKNGD
Atome Classification :
(65 SA)
.........10........20........30........40...-------.....50........60........70........80........90........100.......110..--.....120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.-......310-.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.....--.------------.------------450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640......-.650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170..---....1180......1190......1200......1210.....--------.1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAYS
Y
T
E
K
K
R
I
R
K
N
FGKLPQVMDA
P
Y
L
L
S
I
Q
V
D
S
Y
R
T
F
L
QDGKS-------PKN
R
E
D
I
G
L
Q
A
A
F
R
S
VFPIESYSGN
A
A
L
E
F
V
E
Y
SLGKP
E
F
D
V
R
E
C
I
LRGSTYAA
P
M
R
V
K
I
R
L
I
I
KDRET
K
--
S
I
K
D
V
R
E
QEVYMGEI
P
L
M
TEN
G
T
F
V
ING
T
E
R
V
I
V
S
Q
L
HRSPG
V
F
F
DHDKGKTHSS
G
K
V
L
Y
S
A
R
IIPYRG
S
W
L
D
F
EFDAK
D
L
V
Y
V
R
I
D
R
R
R
K
L
L
A
T
V
V
L
R
A
LGY
N
N
E
Q
I
L
N
L
F
Y
E
KL
P
V
Y
L
DMG
S
Y
Q
I
DLV
P
E
R
LRGEM
A
Q
F
D
ITDNE
G
K
V
I
V
EQGKRI
N
A
R
H
V
R
Q
M
E
A
AG
L
T
KLSV
P
D
E
Y
L
Y
E
R
ITAED-ITLRDG
E
V
I
-
A
A
N
T
LL
S
H
E
V
M
V
K
L
AEGG
V
K
Q
F
N
I
L
F
TNDIDRG
S
F
V
A
D
T
L
R
A
D
L
T
R
D
R
E
E
A
L
V
E
I
Y
K
V
MRPGEPP
T
K
E
A
A
E
N
L
F
N
N
LFFSSERYDLSPV
G
R
M
K
F
N
R
RLGRPYEVGTDQ
K
S
R
E
V
E
G
IL
S
H
E
D
I
I
D
V
L
R
T
L
V
E
I
RNG--K------------G------------EVD
D
I
D
H
LG
N
R
R
V
R
S
V
G
E
M
T
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
QAETDNL
S
P
Q
D
LINA
K
P
V
A
A
A
I
K
E
F
F
G
S
S
Q
L
S
Q
F
M
DQNN
P
L
S
E
I
T
H
K
R
RVSALGPGGLTRERAG
F
E
V
R
D
V
H
Q
THYGRVCPIETPEGPNI
G
L
I
NS
L
S
V
Y
A
KANDFGFLE
T
P
Y
R
K
VVDGRVT
D
D
V
E
Y
L
S
A
I
E
E
V
G
T
V
I
A
QADSAVDKDGN
L
T
E
E
F
V
S
V
RHQ-G
E
F
VRMPPEKVTHMDV
S
A
Q
Q
V
V
S
V
A
A
S
L
I
P
F
LEHDDANRALMGSN
M
Q
R
QAVPTLRADKPLVGTGMEANVARDS
G
V
C
V
I
ANRG
G
V
I
E
Y
VDA
S
R
I
V
I
R
VNEDEMVAGEAG
V
D
I
Y
N
L
I
K
Y
TRSNQNTCINQ
N
V
I
V
NLGDKVARG
D
I
LADGPST
D
M
G
E
LALGQN
M
R
V
A
F
M
T
WNGYNY
E
D
S
I
L
L
S
E
R
V
L
Q
EDR
L
T
S
I
H
I
Q
E
L
S
C
V
ARDTKL
G
A
E
E
I
T
ADIPNV
G
E
A
A
L
S
KLDES
G
I
V
Y
I
G
A
E
V
TAG
D
I
L
V
G
K
VTPKGETQLT
P
E
E
K
L
L
R
A
I
F
GEKAADVKDSSLRVPSGTK
G
T
V
I
D
V
Q
V
F
TRDGLEKDD
R
A
L
A
I
E
K
A
Q
L
D
S
Y
R
K
D
L
K
E
E
Y
K
I
F
E
E
A
A
R
E
R
V
I
R
L
L
KGQESNGGGSTKRG
D
K
L
S
E
D
L
L
S
G
L
E
L
V
D
LLEIQPA
D
E
A
I
A
E
R
L
T
Q
I
Q
V
F
L
K
E
KSA
E
I
D
E
K
F
A
E
K
K
RKLATG
D
E
L
T
T
G
V
L
K
V
V
K
V
Y
L
A
V
K
RRIQPGD
K
M
AGRHGNKGVVSNILPVEDMPHDANG
V
P
V
D
I
V
LNPLGVPSRM
N
V
G
Q
I
L
E
T
H
L
G
M
A
AK
G
L
G
D
K
I
E
K
M
L
K
E
Q
R
T
V
L
E
L
R
E
F
L
D
K
I
Y
N
KVGG---
E
Q
E
D
L
D
SL
T
D
E
E
I
L
A
L
AGNLRAGVPLATPVFDGA
E
E
S
Q
I
K
D
L
L
--------
E
L
A
D
ISRTG
Q
T
V
L
FDGRTGEQFDRP
V
T
V
G
Y
M
Y
M
L
K
L
N
H
LVDDKMHARSTG
S
Y
S
L
V
TQQPLGGKAQFGGQRFGE
M
E
V
W
A
L
EAYG
A
A
Y
T
L
Q
E
M
L
T
VKSDDVE
G
R
T
R
I
Y
K
N
IVDGNHYMDPGMP
E
S
F
N
V
L
T
K
E
I
R
SLG
I
N
I
E
LKNGD
37
PsiBlast_CBE
99.18
70%
0
- C- -
-
4YLN
1
RPOB_ECOLI
I:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
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R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
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V
Q
Y
V
D
A
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R
I
V
I
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V
N
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D
E
M
Y
P
G
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A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
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L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
35
PsiBlast_CBE
99.18
70%
0
- C- -
-
4YLO
1
RPOB_ECOLI
I:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
33
PsiBlast_CBE
99.18
70%
0
- C- -
-
4YLP
1
RPOB_ECOLI
I:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
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K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
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T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
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Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
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T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
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F
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Q
N
N
P
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R
R
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A
L
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G
G
L
T
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E
R
A
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F
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D
V
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Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
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P
Y
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K
V
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V
V
T
D
E
I
H
Y
L
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A
I
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N
Y
V
I
A
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A
N
S
N
L
D
E
E
G
H
F
V
E
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L
V
T
C
R
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K
-
G
E
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S
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Q
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D
Y
M
D
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T
Q
Q
V
V
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A
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A
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A
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A
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A
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K
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A
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A
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A
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Y
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L
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A
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A
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V
K
D
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S
L
R
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N
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V
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G
T
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V
Q
V
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T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
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Y
D
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K
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K
K
L
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A
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A
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Q
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A
A
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A
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A
Y
D
-
L
G
A
DVR
Q
K
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L
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E
E
V
M
R
L
A
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L
R
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F
D
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A
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E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
20
PsiBlast_PDB
99.18
70%
0
- C- -
-
4YLP
1
RPOB_ECOLI
C:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
19
PsiBlast_PDB
99.18
70%
0
- C- -
-
4YLO
1
RPOB_ECOLI
C:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
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K
D
D
V
K
L
I
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V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
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T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
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Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
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A
A
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K
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F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
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I
T
H
K
R
R
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A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
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D
V
H
P
T
H
Y
G
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V
C
P
I
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P
E
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P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
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P
Y
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K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
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G
N
Y
V
I
A
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A
N
S
N
L
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G
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F
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K
-
G
E
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S
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Q
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A
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A
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A
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A
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A
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A
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K
L
L
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A
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K
D
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S
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G
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Q
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T
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D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
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F
E
K
K
L
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A
K
R
R
K
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G
D
D
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A
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V
L
K
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L
A
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R
R
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M
A
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H
G
N
K
G
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Q
I
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M
A
A
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G
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A
K
L
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A
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D
-
L
G
A
DVR
Q
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V
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V
M
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L
A
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N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
18
PsiBlast_PDB
99.18
70%
0
- C- -
-
4YLN
1
RPOB_ECOLI
C:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
13
PsiBlast_PDB
72.96
70%
33
- C5 -
-
4MEY
-
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
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T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
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V
G
A
S
L
I
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F
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D
A
N
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A
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A
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Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
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A
V
D
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G
V
T
A
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A
K
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G
G
V
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A
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I
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V
N
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M
Y
P
G
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A
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I
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I
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N
L
T
K
Y
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R
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N
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N
T
C
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Q
M
P
C
V
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L
G
E
P
V
E
R
G
D
V
L
A
D
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D
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L
A
L
G
Q
N
M
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A
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M
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W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
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L
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P
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A
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P
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V
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E
A
A
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K
L
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G
I
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Y
I
G
A
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G
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I
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K
G
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T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
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F
E
K
K
L
E
A
K
R
R
K
I
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G
D
D
L
A
P
G
V
L
K
I
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Y
L
A
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R
R
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K
M
A
G
R
H
G
N
K
G
V
I
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K
I
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M
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D
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M
N
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Q
I
L
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T
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L
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M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
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A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
12
PsiBlast_PDB
72.91
70%
32
- C5 -
-
4MEX
-
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
25
PsiBlast_CBE
72.21
70%
36
- C5 -
-
5IPL
1
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
4
PsiBlast_PDB
72.08
70%
33
- C5 -
-
4JKR
-
?
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
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P
V
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Y
I
A
G
K
V
V
A
K
D
Y
I
D
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T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
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Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
17
PsiBlast_PDB
71.95
70%
36
- C5 -
-
4YG2
-
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
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R
R
I
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A
R
H
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Q
L
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K
D
D
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K
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P
V
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Y
I
A
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V
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A
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D
Y
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E
L
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C
A
A
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M
E
L
S
L
D
L
L
A
K
L
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Q
S
G
H
K
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T
L
F
T
N
D
L
D
H
G
P
Y
I
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L
R
V
D
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T
N
D
R
L
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A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
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E
I
T
H
K
R
R
I
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A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
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T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
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P
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K
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V
V
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D
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I
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A
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N
Y
V
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A
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A
N
S
N
L
D
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C
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S
K
-
G
E
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S
L
F
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D
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V
D
Y
M
D
V
S
T
Q
Q
V
V
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A
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A
N
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A
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A
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A
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P
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A
D
K
P
L
V
G
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M
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A
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A
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G
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A
V
A
K
R
G
G
V
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A
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I
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V
N
E
D
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M
Y
P
G
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A
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I
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T
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Y
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R
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L
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V
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G
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A
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A
L
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A
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N
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N
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S
I
L
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V
V
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F
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I
Q
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A
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A
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Q
L
T
P
E
E
K
L
L
R
A
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G
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K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
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Y
D
E
L
K
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K
K
L
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A
K
R
R
K
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A
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L
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Y
L
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R
R
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A
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R
H
G
N
K
G
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T
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L
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A
A
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I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
11
PsiBlast_PDB
71.92
70%
35
- C5 -
-
4LLG
-
?
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
46
PsiBlast_CBE
71.88
70%
35
- C5 -
-
4XSX
1
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
29
PsiBlast_CBE
71.85
70%
35
- C5 -
-
4ZH3
1
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
27
PsiBlast_CBE
71.82
70%
35
- C5 -
-
4ZH4
1
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
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V
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A
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I
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A
N
R
A
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A
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M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
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A
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G
V
T
A
V
A
K
R
G
G
V
V
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Y
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A
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R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
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I
D
I
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L
T
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Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
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T
D
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L
A
L
G
Q
N
M
R
V
A
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M
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W
N
G
Y
N
F
E
D
S
I
L
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E
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V
V
Q
E
D
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F
T
T
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H
I
Q
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A
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A
A
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K
L
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I
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G
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K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
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G
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K
A
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D
V
K
D
S
S
L
R
V
P
N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
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K
V
Y
L
A
V
K
R
R
I
Q
P
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D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
24
PsiBlast_CBE
71.82
70%
37
- C5 -
-
5UAC
1
RPOB_ECOLI
C:
[1-1341]
M
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
45
PsiBlast_CBE
71.80
70%
35
- C5 -
-
4XSX
1
RPOB_ECOLI
I:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
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S
T
Q
Q
V
V
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A
S
L
I
P
F
L
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D
D
A
N
R
A
L
M
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A
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M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
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M
E
R
A
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A
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G
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T
A
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A
K
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G
G
V
V
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Y
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A
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I
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I
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V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
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N
L
T
K
Y
T
R
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N
Q
N
T
C
I
N
Q
M
P
C
V
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L
G
E
P
V
E
R
G
D
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L
A
D
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D
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L
A
L
G
Q
N
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A
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M
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W
N
G
Y
N
F
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S
I
L
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F
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T
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I
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A
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A
A
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K
L
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G
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G
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T
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L
T
P
E
E
K
L
L
R
A
I
F
G
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K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
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G
D
D
L
A
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V
L
K
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Y
L
A
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R
R
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P
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D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
10
PsiBlast_PDB
71.78
70%
36
- C5 -
-
4LK1
-
?
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
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N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
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F
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I
R
D
N
K
L
Q
M
E
L
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L
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A
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F
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A
N
-
G
K
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K
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L
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A
A
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M
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L
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L
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L
L
A
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L
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D
L
D
H
G
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Y
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L
R
V
D
P
T
N
D
R
L
S
A
L
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Y
R
M
M
R
P
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P
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A
A
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L
F
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N
L
F
F
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D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
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N
A
K
P
I
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A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
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A
L
G
P
G
G
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A
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Y
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C
P
I
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N
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L
I
N
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L
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A
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V
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D
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A
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N
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V
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A
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A
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N
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D
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H
F
V
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D
L
V
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C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
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V
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A
S
L
I
P
F
L
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H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
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A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
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V
N
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D
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Y
P
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A
G
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I
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N
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Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
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D
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L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
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V
V
Q
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D
R
F
T
T
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H
I
Q
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L
A
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D
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K
L
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P
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A
D
I
P
N
V
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A
A
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L
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G
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K
V
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P
K
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T
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L
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P
E
E
K
L
L
R
A
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A
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K
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V
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N
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V
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G
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V
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V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
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M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
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N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
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T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
14
PsiBlast_PDB
71.69
70%
37
- C5 -
-
4YFK
1
RPOB_ECO24
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
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V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
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N
G
T
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R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
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I
R
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N
K
L
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M
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P
E
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L
R
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A
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A
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-
G
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V
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L
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Y
R
M
M
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P
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E
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P
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A
A
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L
F
E
N
L
F
F
S
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D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
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L
S
L
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D
L
D
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L
M
P
Q
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M
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A
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P
I
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A
A
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F
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N
N
P
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A
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A
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L
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Y
A
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A
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-
G
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Y
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Q
V
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A
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A
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A
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A
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P
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A
K
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A
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I
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A
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L
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L
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A
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D
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K
D
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S
L
R
V
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N
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V
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G
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V
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F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
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Y
D
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K
L
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A
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R
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A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
42
PsiBlast_CBE
71.68
70%
36
- C5 -
-
4XSZ
1
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
23
PsiBlast_CBE
71.21
70%
34
- C5 -
-
5UP6
1
RPOB_ECOLI
I:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
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H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
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E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
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G
I
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Y
I
G
A
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T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
21
PsiBlast_CBE
71.05
70%
36
- C5 -
-
5UPC
1
RPOB_ECOLI
I:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
22
PsiBlast_CBE
70.70
70%
36
* C5 *
-
5UPA
1
?
I:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
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R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
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D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
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T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
128
HHSearch
57.20
56%
36
- C5 -
-
5UHA
2
RPOB_MYCTU
C:
[35-1140]
--------
A
P
N
R
V
S
F
A
K
L
R
E
P
L
E
V
P
G
L
L
D
V
Q
T
D
S
F
E
W
L
I
G
S
P
R
W
R
E
S
A
A
E
R
G
D
V
N
P
V
G
G
L
E
E
V
L
Y
E
L
S
P
I
E
D
F
S
G
S
M
S
L
S
F
S
D
P
R
F
D
D
V
K
A
P
V
D
E
C
K
D
K
D
M
T
Y
A
A
P
L
F
V
T
A
E
F
I
N
N
N
T
-------
G
E
I
K
S
Q
T
V
F
M
G
D
F
P
M
M
T
E
K
G
T
F
I
I
N
G
T
E
R
V
V
V
S
Q
L
V
R
S
P
G
V
Y
F
D
E
T
I
D
K
S
T
--
D
K
T
L
H
S
V
K
V
I
P
S
R
G
A
W
L
E
F
D
V
D
K
R
D
T
V
G
V
R
I
D
R
K
R
R
Q
P
V
T
V
L
L
K
A
L
G
W
T
S
E
Q
I
V
E
R
F
G
F
S
E
I
M
R
----------------------------------------------------------------------------------------------------------------------
S
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
L
H
V
G
E
------
P
I
T
S
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
T
T
M
T
V
PGG
V
E
V
P
V
------------
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
M
H
D
N
-------
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
D
E
D
----------------------------------------------------------------------------------------------------------------
E
L
P
A
G
V
N
E
L
V
R
V
Y
V
A
Q
K
R
K
I
S
D
G
D
K
L
A
G
R
H
G
N
K
G
V
I
G
K
I
L
P
V
E
D
M
P
F
L
A
D
G
T
P
V
D
I
I
L
N
T
H
G
V
P
R
R
M
N
I
G
Q
I
L
E
T
H
L
G
W
C
A
H
-
S
G
W
K
V
D
A
A
K
G
-----------
V
P
D
W
A
A
R
L
P
D
E--
L
L
E
A
----------------
Q
P
N
A
I
V
S
T
P
V
F
D
G
A
Q
E
A
E
L
Q
G
L
L
S
C
T
L
P
N
RD
G
D
V
L
V
D
A
D
G
K
A
M
L
F
D
G
R
S
G
E
P
F
P
Y
P
V
T
V
G
Y
M
Y
I
M
K
L
H
H
L
V
D
D
K
I
H
A
R
S
T
G
P
Y
S
M
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
C
W
A
M
Q
A
Y
G
A
A
Y
T
L
Q
E
L
L
T
I
K
S
D
D
T
V
G
R
V
K
V
Y
E
A
I
V
K
G
E
N
I
P
E
P
G
I
P
E
S
F
K
V
L
L
K
E
L
Q
S
L
C
L
N
V
E
V
L
S
S
-
79
PsiBlast_CBE
44.76
53%
19
- C5 -
-
5D4E
1
RPOB_THET8
M:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
44.76
53%
15
- C5 -
-
5X22
1
?
M:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
44.64
53%
20
- C5 -
-
5I2D
1
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
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R
M
L
M
G
S
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S
L
T
P
A
K
L
V
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L
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F
S
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S
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L
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T
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P
L
S
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L
R
H
K
R
R
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A
L
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P
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L
T
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A
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F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
44.53
53%
17
- C5 -
-
4G7H
1
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
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K
Q
V
F
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V
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T
N
L
I
P
F
L
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H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
44.37
53%
21
- C5 -
-
5I2D
1
RPOB_THET8
N:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
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D
S
L
T
P
A
K
L
V
N
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P
L
E
A
A
I
R
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F
F
S
R
S
Q
L
S
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K
D
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T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
44.34
53%
18
- C5 -
-
4G7H
2
RPOB_THET8
M:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
44.30
53%
18
- C5 -
-
4G7O
3
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
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D
R
Y
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I
A
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A
N
T
P
L
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G
N
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R
I
A
A
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V
V
A
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R
K
-
G
E
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V
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E
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V
S
P
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Q
V
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T
N
L
I
P
F
L
E
H
D
D
A
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R
A
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M
G
S
N
M
Q
T
Q
A
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P
L
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A
Q
A
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V
V
M
T
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L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
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E
D
G
E
V
A
K
V
D
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N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
44.20
53%
19
- C5 -
-
4G7O
3
RPOB_THET8
M:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
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S
E
D
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L
T
P
A
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L
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A
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R
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F
F
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Q
L
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K
D
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T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
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T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
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R
V
V
A
R
R
K
-
G
E
P
V
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S
P
E
E
V
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A
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V
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L
E
E
R
V
V
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L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
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G
V
V
R
I
G
A
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K
P
G
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L
V
G
R
T
S
F
K
G
E
S
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T
P
E
E
R
L
L
R
S
I
F
G
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K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
44.09
53%
22
- C5 -
-
4OIQ
2
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
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D
S
L
T
P
A
K
L
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N
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R
P
L
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A
A
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R
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F
F
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S
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L
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K
D
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T
N
P
L
S
S
L
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H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
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D
E
V
V
Y
M
T
A
T
E
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D
R
Y
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I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
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R
V
V
A
R
R
K
-
G
E
P
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S
P
E
E
V
E
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M
D
V
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F
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T
N
L
I
P
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D
D
A
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R
A
L
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G
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N
M
Q
T
Q
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P
L
I
R
A
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A
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V
V
M
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G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
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D
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D
E
E
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V
V
R
I
G
A
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K
P
G
D
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L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
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R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
44.09
53%
20
- C5 -
-
5X22
2
?
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
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R
M
L
M
G
S
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D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
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V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
44.07
53%
17
- C5 -
-
5X21
2
?
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
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A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
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V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
43.92
53%
19
- C5 -
-
4OIN
2
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
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K
R
R
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A
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L
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A
Y
A
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V
D
E
L
G
F
I
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P
Y
R
R
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V
G
G
V
V
T
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E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
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P
E
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L
I
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D
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R
A
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M
Q
T
Q
A
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P
L
I
R
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A
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V
V
M
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L
E
E
R
V
V
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D
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L
A
A
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A
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D
G
E
V
A
K
V
D
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N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
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N
G
F
L
A
L
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Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
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R
Y
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A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
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A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
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K
P
G
D
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L
V
G
R
T
S
F
K
G
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S
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P
E
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R
L
L
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F
G
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K
A
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D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
43.83
53%
19
- C5 -
-
4Q4Z
3
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
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Q
F
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L
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R
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M
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P
L
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S
L
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K
R
R
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R
A
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D
V
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Y
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P
V
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A
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I
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V
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F
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Y
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M
T
A
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R
Y
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A
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A
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T
P
L
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G
N
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R
I
A
A
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V
V
A
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K
-
G
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V
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L
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L
A
A
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A
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G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
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I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
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K
P
G
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L
V
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R
T
S
F
K
G
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S
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P
E
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R
L
L
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I
F
G
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K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
43.78
53%
20
- C5 -
-
5D4E
2
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
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L
M
T
D
Q
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A
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L
A
R
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V
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M
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K
R
R
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A
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G
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R
A
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F
D
V
R
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H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
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L
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A
Y
A
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V
D
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L
G
F
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P
Y
R
R
V
V
G
G
V
V
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V
V
Y
M
T
A
T
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D
R
Y
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A
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A
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T
P
L
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G
N
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R
I
A
A
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V
V
A
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R
K
-
G
E
P
V
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P
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V
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N
L
I
P
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A
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R
A
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M
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V
M
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L
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R
V
V
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S
L
A
A
L
Y
A
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E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
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I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
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A
A
L
R
D
L
D
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V
V
R
I
G
A
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K
P
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L
V
G
R
T
S
F
K
G
E
S
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T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
43.64
53%
21
- C5 -
-
4OIR
3
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
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A
A
I
R
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F
F
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R
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Q
L
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K
D
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T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
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I
A
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A
N
T
P
L
E
G
N
-
R
I
A
A
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R
V
V
A
R
R
K
-
G
E
P
V
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S
P
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V
E
F
M
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V
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V
F
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V
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T
N
L
I
P
F
L
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H
D
D
A
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R
A
L
M
G
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N
M
Q
T
Q
A
V
P
L
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R
A
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A
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V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
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K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
43.64
53%
21
- C5 -
-
5E17
2
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
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G
L
A
R
L
A
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G
V
R
E
R
M
L
M
G
S
E
D
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L
T
P
A
K
L
V
N
S
R
P
L
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A
A
I
R
E
F
F
S
R
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Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
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A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
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Y
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V
V
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M
T
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R
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N
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-------
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S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
43.47
53%
24
- C5 -
-
4OIP
2
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
43.25
53%
20
- C5 -
-
4OIO
4
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
43.09
53%
21
- C5 -
-
4G7Z
2
RPOB_THET8
M:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
42.91
53%
22
- C5 -
-
5E18
2
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
42.87
53%
20
- C5 -
-
5VO8
3
?
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
----
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
42.37
53%
21
- C5 -
-
4Q5S
4
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
42.03
58%
46
- C5 -
-
5UH9
2
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
41.96
53%
24
- C5 -
-
4G7Z
2
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
41.75
58%
47
- C5 -
-
5UHD
3
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
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Y
R
K
V
V
D
G
V
V
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D
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Y
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R
H
V
V
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A
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S
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I
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A
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R
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L
V
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R
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A
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E
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Y
V
P
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S
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Y
M
D
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V
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A
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A
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V
V
A
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V
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A
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Y
I
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-------
M
H
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R
R
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Y
R
M
R
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A
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P
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D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
41.69
58%
47
- C5 -
-
5UHA
2
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
41.67
58%
47
- C5 -
-
5UHC
4
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
41.62
58%
48
- C5 -
-
5UHB
3
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
41.34
58%
47
- C5 -
-
5UHG
4
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
41.24
58%
47
- C5 -
-
5UHE
3
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
41.23
58%
48
- C5 -
-
5UH6
4
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
41.21
58%
50
- C5 -
-
5UH5
3
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
40.94
58%
48
- C5 -
-
5UH8
3
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
40.46
58%
45
- C5 -
-
5UHF
3
RPOB_MYCTU
C:
[261-856]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
K
D
N
T
V
G
T
D
E
A
L
L
D
I
Y
R
K
L
R
P
G
E
P
P
T
K
E
S
A
Q
T
L
L
E
N
L
F
F
K
E
K
R
Y
D
L
A
R
V
G
R
Y
K
V
N
K
K
L
G
--
L
H
V
G
E
P
I
T
S
----
S
T
L
T
E
E
D
V
V
A
T
I
E
Y
L
V
R
L
H
E
G
--
Q
------------
T
T
M
T
V
PGG
V
E
V
P
V
E
T
D
D
I
D
H
F
G
N
R
R
L
R
T
V
G
E
L
I
Q
N
Q
I
R
V
G
M
S
R
M
E
R
V
V
R
E
R
M
T
T
Q
D
V
E
A
I
T
P
Q
T
L
I
N
I
R
P
V
V
A
A
I
K
E
F
F
G
T
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
G
L
T
H
K
R
R
L
S
A
L
G
P
G
G
L
S
R
E
R
A
G
L
E
V
R
D
V
H
P
S
H
Y
G
R
M
C
P
I
E
T
P
E
G
P
N
I
G
L
I
G
S
L
S
V
Y
A
R
V
N
P
F
G
F
I
E
T
P
Y
R
K
V
V
D
G
V
V
S
D
E
I
V
Y
L
T
A
D
E
E
D
R
H
V
V
A
Q
A
N
S
P
I
D
A
D
G
R
F
V
E
P
R
V
L
V
R
R
K
A
G
E
V
E
Y
V
P
S
S
E
V
D
Y
M
D
V
S
P
R
Q
M
V
S
V
A
T
A
M
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
L
V
R
S
E
A
P
L
V
G
T
G
M
E
L
R
A
A
I
D
A
G
D
V
V
V
A
E
E
S
G
V
I
E
E
V
S
A
D
Y
I
T
V
-------
M
H
D
N
G
T
R
R
T
Y
R
M
R
K
F
A
R
S
N
H
G
T
C
A
N
Q
C
P
I
V
D
A
G
D
R
V
E
A
G
Q
V
I
A
D
G
P
C
T
D
D
G
E
M
A
L
G
K
N
L
L
V
A
I
M
P
W
E
G
H
N
Y
E
D
A
I
I
L
S
N
R
L
V
E
E
D
V
L
T
S
I
H
I
E
E
H
E
I
D
A
R
D
T
K
L
G
A
E
E
I
T
R
D
I
P
N
I
S
D
E
V
L
A
D
L
D
E
R
G
I
V
R
I
G
A
E
V
R
D
G
D
I
L
V
G
K
V
T
P
K
G
E
T
E
L
T
P
E
E
R
L
L
R
A
I
F
G
E
K
A
R
E
V
R
D
T
S
L
K
V
P
H
G
E
S
G
K
V
I
G
I
R
V
F
S
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
39.42
53%
24
- C5 -
-
3AOH
2
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
38.88
53%
28
- C5 -
-
2O5I
3
RPOB_THET8
M:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
38.76
53%
27
- C5 -
-
2O5I
3
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
38.56
53%
30
- C5 -
-
2O5J
4
RPOB_THET8
M:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
38.44
53%
29
- C5 -
-
4WQS
2
RPOB_THET8
M:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
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T
N
P
L
S
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L
R
H
K
R
R
I
S
A
L
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P
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L
T
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A
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F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
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K
P
G
D
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G
R
T
S
F
K
G
E
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P
E
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R
L
L
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F
G
E
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A
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D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
37.55
53%
31
- C5 -
-
4WQS
2
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
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M
L
M
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S
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D
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L
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P
A
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L
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L
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A
A
I
R
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F
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R
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Q
L
S
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K
D
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T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
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V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
-
G
E
P
V
I
V
S
P
E
E
V
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F
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V
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T
N
L
I
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D
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A
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R
A
L
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N
M
Q
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Q
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L
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V
M
T
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L
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E
R
V
V
R
D
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L
A
A
L
Y
A
E
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D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
R
L
V
E
-------
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
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I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
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S
E
A
A
L
R
D
L
D
E
E
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V
V
R
I
G
A
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K
P
G
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G
R
T
S
F
K
G
E
S
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T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
37.24
53%
33
- C5 -
-
2O5J
4
RPOB_THET8
C:
[232-801]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
--
I
R
L
S
G
R
T
L
A
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
VP
G
------------
H
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
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P
L
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L
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K
R
R
I
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A
L
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P
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G
L
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A
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F
D
V
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D
V
H
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Y
G
R
I
C
P
V
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P
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A
N
I
G
L
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T
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A
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V
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A
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L
R
V
P
P
G
E
G
G
I
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------