@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLZ6: (2017-11-05 )
MAYSYTEKKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQDGKSPKNREDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDVRECILRGSTYAAPMRVKIRLIIKDRETKSIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKTHSSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQILNLFYEKLPVYLDMGSYQIDLVPERLRGEMAQFDITDNEGKVIVEQGKRINARHVRQMEAAGLTKLSVPDEYLYERITAEDITLRDGEVIAANTLLSHEVMVKLAEGGVKQFNILFTNDIDRGSFVADTLRADLTRDREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKFNRRLGRPYEVGTDQKSREVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDDVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVARDSGVCVIANRGGVIEYVDASRIVIRVNEDEMVAGEAGVDIYNLIKYTRSNQNTCINQNVIVNLGDKVARGDILADGPSTDMGELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGLEKDDRALAIEKAQLDSYRKDLKEEYKIFEEAARERVIRLLKGQESNGGGSTKRGDKLSEDLLSGLELVDLLEIQPADEAIAERLTQIQVFLKEKSAEIDEKFAEKKRKLATGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILETHLGMAAKGLGDKIEKMLKEQRTVLELREFLDKIYNKVGGEQEDLDSLTDEEILALAGNLRAGVPLATPVFDGAEESQIKDLLELADISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIELKNGD
Atome Classification :
(65 SA)
.........10........20........30........40...-------.....50........60........70........80........90........100.......110..--.....120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.-......310-.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.....--.------------.------------450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640......-.650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170..---....1180......1190......1200......1210.....--------.1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAYS
Y
T
E
K
K
R
I
R
K
N
FGKLPQVMDA
P
Y
L
L
S
I
Q
V
D
S
Y
R
T
F
L
QDGKS-------PKN
R
E
D
I
G
L
Q
A
A
F
R
S
VFPIESYSGN
A
A
L
E
F
V
E
Y
SLGKP
E
F
D
V
R
E
C
I
LRGSTYAA
P
M
R
V
K
I
R
L
I
I
KDRET
K
--
S
I
K
D
V
R
E
QEVYMGEI
P
L
M
TEN
G
T
F
V
ING
T
E
R
V
I
V
S
Q
L
HRSPG
V
F
F
DHDKGKTHSS
G
K
V
L
Y
S
A
R
IIPYRG
S
W
L
D
F
EFDAK
D
L
V
Y
V
R
I
D
R
R
R
K
L
L
A
T
V
V
L
R
A
LGY
N
N
E
Q
I
L
N
L
F
Y
E
KL
P
V
Y
L
DMG
S
Y
Q
I
DLV
P
E
R
LRGEM
A
Q
F
D
ITDNE
G
K
V
I
V
EQGKRI
N
A
R
H
V
R
Q
M
E
A
AG
L
T
KLSV
P
D
E
Y
L
Y
E
R
ITAED-ITLRDG
E
V
I
-
A
A
N
T
LL
S
H
E
V
M
V
K
L
AEGG
V
K
Q
F
N
I
L
F
TNDIDRG
S
F
V
A
D
T
L
R
A
D
L
T
R
D
R
E
E
A
L
V
E
I
Y
K
V
MRPGEPP
T
K
E
A
A
E
N
L
F
N
N
LFFSSERYDLSPV
G
R
M
K
F
N
R
RLGRPYEVGTDQ
K
S
R
E
V
E
G
IL
S
H
E
D
I
I
D
V
L
R
T
L
V
E
I
RNG--K------------G------------EVD
D
I
D
H
LG
N
R
R
V
R
S
V
G
E
M
T
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
QAETDNL
S
P
Q
D
LINA
K
P
V
A
A
A
I
K
E
F
F
G
S
S
Q
L
S
Q
F
M
DQNN
P
L
S
E
I
T
H
K
R
RVSALGPGGLTRERAG
F
E
V
R
D
V
H
Q
THYGRVCPIETPEGPNI
G
L
I
NS
L
S
V
Y
A
KANDFGFLE
T
P
Y
R
K
VVDGRVT
D
D
V
E
Y
L
S
A
I
E
E
V
G
T
V
I
A
QADSAVDKDGN
L
T
E
E
F
V
S
V
RHQ-G
E
F
VRMPPEKVTHMDV
S
A
Q
Q
V
V
S
V
A
A
S
L
I
P
F
LEHDDANRALMGSN
M
Q
R
QAVPTLRADKPLVGTGMEANVARDS
G
V
C
V
I
ANRG
G
V
I
E
Y
VDA
S
R
I
V
I
R
VNEDEMVAGEAG
V
D
I
Y
N
L
I
K
Y
TRSNQNTCINQ
N
V
I
V
NLGDKVARG
D
I
LADGPST
D
M
G
E
LALGQN
M
R
V
A
F
M
T
WNGYNY
E
D
S
I
L
L
S
E
R
V
L
Q
EDR
L
T
S
I
H
I
Q
E
L
S
C
V
ARDTKL
G
A
E
E
I
T
ADIPNV
G
E
A
A
L
S
KLDES
G
I
V
Y
I
G
A
E
V
TAG
D
I
L
V
G
K
VTPKGETQLT
P
E
E
K
L
L
R
A
I
F
GEKAADVKDSSLRVPSGTK
G
T
V
I
D
V
Q
V
F
TRDGLEKDD
R
A
L
A
I
E
K
A
Q
L
D
S
Y
R
K
D
L
K
E
E
Y
K
I
F
E
E
A
A
R
E
R
V
I
R
L
L
KGQESNGGGSTKRG
D
K
L
S
E
D
L
L
S
G
L
E
L
V
D
LLEIQPA
D
E
A
I
A
E
R
L
T
Q
I
Q
V
F
L
K
E
KSA
E
I
D
E
K
F
A
E
K
K
RKLATG
D
E
L
T
T
G
V
L
K
V
V
K
V
Y
L
A
V
K
RRIQPGD
K
M
AGRHGNKGVVSNILPVEDMPHDANG
V
P
V
D
I
V
LNPLGVPSRM
N
V
G
Q
I
L
E
T
H
L
G
M
A
AK
G
L
G
D
K
I
E
K
M
L
K
E
Q
R
T
V
L
E
L
R
E
F
L
D
K
I
Y
N
KVGG---
E
Q
E
D
L
D
SL
T
D
E
E
I
L
A
L
AGNLRAGVPLATPVFDGA
E
E
S
Q
I
K
D
L
L
--------
E
L
A
D
ISRTG
Q
T
V
L
FDGRTGEQFDRP
V
T
V
G
Y
M
Y
M
L
K
L
N
H
LVDDKMHARSTG
S
Y
S
L
V
TQQPLGGKAQFGGQRFGE
M
E
V
W
A
L
EAYG
A
A
Y
T
L
Q
E
M
L
T
VKSDDVE
G
R
T
R
I
Y
K
N
IVDGNHYMDPGMP
E
S
F
N
V
L
T
K
E
I
R
SLG
I
N
I
E
LKNGD
37
PsiBlast_CBE
99.18
70%
0
- C- -
-
4YLN
1
RPOB_ECOLI
I:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
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R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
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V
Q
Y
V
D
A
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R
I
V
I
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V
N
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D
E
M
Y
P
G
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A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
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L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
35
PsiBlast_CBE
99.18
70%
0
- C- -
-
4YLO
1
RPOB_ECOLI
I:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
33
PsiBlast_CBE
99.18
70%
0
- C- -
-
4YLP
1
RPOB_ECOLI
I:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
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K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
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T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
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Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
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T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
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F
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Q
N
N
P
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R
R
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A
L
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G
G
L
T
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E
R
A
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F
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D
V
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Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
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P
Y
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K
V
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V
V
T
D
E
I
H
Y
L
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A
I
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N
Y
V
I
A
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A
N
S
N
L
D
E
E
G
H
F
V
E
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L
V
T
C
R
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K
-
G
E
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S
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Q
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D
Y
M
D
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T
Q
Q
V
V
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A
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A
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A
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A
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A
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K
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A
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A
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A
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Y
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L
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A
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A
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V
K
D
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S
L
R
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N
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V
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G
T
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V
Q
V
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T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
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Y
D
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K
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K
K
L
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A
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A
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Q
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A
A
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A
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A
Y
D
-
L
G
A
DVR
Q
K
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L
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E
E
V
M
R
L
A
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L
R
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F
D
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A
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E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
20
PsiBlast_PDB
99.18
70%
0
- C- -
-
4YLP
1
RPOB_ECOLI
C:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
19
PsiBlast_PDB
99.18
70%
0
- C- -
-
4YLO
1
RPOB_ECOLI
C:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
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K
D
D
V
K
L
I
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V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
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T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
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Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
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A
A
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K
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F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
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I
T
H
K
R
R
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A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
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D
V
H
P
T
H
Y
G
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V
C
P
I
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P
E
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P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
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P
Y
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K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
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G
N
Y
V
I
A
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A
N
S
N
L
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G
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F
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K
-
G
E
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S
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Q
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A
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A
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A
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A
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A
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A
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K
L
L
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A
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K
D
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S
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G
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Q
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T
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D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
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F
E
K
K
L
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A
K
R
R
K
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G
D
D
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A
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V
L
K
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L
A
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R
R
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M
A
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H
G
N
K
G
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Q
I
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M
A
A
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G
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A
K
L
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A
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D
-
L
G
A
DVR
Q
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V
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V
M
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L
A
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N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
18
PsiBlast_PDB
99.18
70%
0
- C- -
-
4YLN
1
RPOB_ECOLI
C:
[2-1341]
-
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
13
PsiBlast_PDB
72.96
70%
33
- C5 -
-
4MEY
-
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
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T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
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V
G
A
S
L
I
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F
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D
A
N
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A
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A
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Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
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A
V
D
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G
V
T
A
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A
K
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G
G
V
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A
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I
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V
N
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M
Y
P
G
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A
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I
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I
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N
L
T
K
Y
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R
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N
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N
T
C
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Q
M
P
C
V
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L
G
E
P
V
E
R
G
D
V
L
A
D
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D
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L
A
L
G
Q
N
M
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A
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M
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W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
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L
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P
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A
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P
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V
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E
A
A
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K
L
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G
I
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Y
I
G
A
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G
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I
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K
G
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T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
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F
E
K
K
L
E
A
K
R
R
K
I
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G
D
D
L
A
P
G
V
L
K
I
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Y
L
A
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R
R
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K
M
A
G
R
H
G
N
K
G
V
I
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K
I
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M
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D
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M
N
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Q
I
L
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T
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L
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M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
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A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
12
PsiBlast_PDB
72.91
70%
32
- C5 -
-
4MEX
-
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
25
PsiBlast_CBE
72.21
70%
36
- C5 -
-
5IPL
1
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
4
PsiBlast_PDB
72.08
70%
33
- C5 -
-
4JKR
-
?
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
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P
V
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Y
I
A
G
K
V
V
A
K
D
Y
I
D
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T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
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Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
17
PsiBlast_PDB
71.95
70%
36
- C5 -
-
4YG2
-
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
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R
R
I
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A
R
H
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Q
L
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K
D
D
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K
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P
V
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Y
I
A
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V
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A
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D
Y
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E
L
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C
A
A
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M
E
L
S
L
D
L
L
A
K
L
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Q
S
G
H
K
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T
L
F
T
N
D
L
D
H
G
P
Y
I
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L
R
V
D
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T
N
D
R
L
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A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
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E
I
T
H
K
R
R
I
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A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
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T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
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P
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K
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V
V
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D
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I
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A
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N
Y
V
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A
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A
N
S
N
L
D
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C
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S
K
-
G
E
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S
L
F
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D
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V
D
Y
M
D
V
S
T
Q
Q
V
V
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A
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A
N
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A
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A
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A
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P
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A
D
K
P
L
V
G
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M
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A
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A
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G
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A
V
A
K
R
G
G
V
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A
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I
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V
N
E
D
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M
Y
P
G
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A
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I
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T
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Y
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R
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L
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V
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G
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A
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A
L
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A
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N
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N
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S
I
L
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V
V
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F
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I
Q
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A
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A
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Q
L
T
P
E
E
K
L
L
R
A
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G
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K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
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Y
D
E
L
K
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K
K
L
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A
K
R
R
K
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A
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L
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Y
L
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R
R
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A
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R
H
G
N
K
G
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T
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L
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A
A
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I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
11
PsiBlast_PDB
71.92
70%
35
- C5 -
-
4LLG
-
?
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
46
PsiBlast_CBE
71.88
70%
35
- C5 -
-
4XSX
1
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
29
PsiBlast_CBE
71.85
70%
35
- C5 -
-
4ZH3
1
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
27
PsiBlast_CBE
71.82
70%
35
- C5 -
-
4ZH4
1
RPOB_ECOLI
C:
[3-1341]
--
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
EG
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
N
-
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
E
T
L
R
V
D
P
T
N
D
R
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
--------
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
--
K
------------
G
------------
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
-
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
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V
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A
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I
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A
N
R
A
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A
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M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
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A
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G
V
T
A
V
A
K
R
G
G
V
V
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Y
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A
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R
I
V
I
K
V
N
E
D
E
M
Y
P
G
E
A
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I
D
I
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L
T
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Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
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T
D
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L
A
L
G
Q
N
M
R
V
A
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M
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W
N
G
Y
N
F
E
D
S
I
L
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E
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V
V
Q
E
D
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F
T
T
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H
I
Q
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A
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A
A
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K
L
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I
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G
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K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
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G
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K
A
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D
V
K
D
S
S
L
R
V
P
N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
----
G
G
V
E
A
E
K
L
D
K
L
P
R
D
--------
R
W
L
E
L
G
L
T
D
E
E
K
Q
N
Q
L
E
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
G
V
L
K
I
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K
V
Y
L
A
V
K
R
R
I
Q
P
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D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
-
L
G
A
DVR
Q
K
V
D
L
S
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
--------
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
--
24
PsiBlast_CBE
71.82
70%
37
- C5 -
-
5UAC
1
RPOB_ECOLI
C:
[1-1341]
M
V
Y
S
Y
T
E
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
--
Q
D
-------
P
E
G
Q
--
Y
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L
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A
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F
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S
V
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I
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N
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--
K
------------
G
------------
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L
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L
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L
E
D
--