@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM29: (2017-11-05 )
MKIQGKHFVITGGGSGLGAATAEYLVKQGASVTLVDMNVEAGEQQAKHLGPKAGFVKLDVTDEATAEQFFKDVLVKHGHLHGLVNCAGIGPSAKVVGREGVHDLGLFAKTLNINVTGTFNMLRFAADAMSKNTVEEGEEDRGIIVNTASVAAFDGQIGQAAYSASKGAIVAMTLPIARELARHAIRIMTIAPGIMETPMLKGMPQNVQDALGQMVPYPSRLGKPEEFARLVAHIAENSYLNGEVIRLDGAIRMAAK
Atome Classification :
(37 SA)
.........10........20........30........40........50........60........70........80........90....--.--...100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKIQG
K
H
F
V
I
TGGGSG
L
G
A
A
T
A
E
Y
L
V
KQG
A
S
V
T
L
V
D
M
NVEA
G
E
Q
Q
A
K
HLGPKA
G
F
V
K
L
DVTD
E
A
T
A
E
Q
F
F
K
D
V
L
V
KHGHLH
G
L
V
NCAGIGPS
A
K
V--V--GREG
V
H
D
L
G
L
F
A
K
T
L
N
I
N
V
T
G
T
F
N
M
L
R
F
A
A
D
A
MSKNTVEEGEEDR
G
I
I
V
N
T
A
S
V
A
AFDGQI
G
Q
A
AYSASK
G
A
I
V
A
M
T
L
P
I
A
R
E
L
A
R
H
A
I
R
I
M
T
IAPGIMET
P
M
LKGM
P
Q
N
V
Q
D
A
L
G
QMVPY
P
S
RLG
K
P
E
E
F
A
R
L
V
A
H
I
AENSYLN
G
E
V
I
R
LDG
A
I
R
MAAK
35
PsiBlast_CBE
93.65
61%
-107
- C1 -
-
4XGN
4
?
B:
[9-260]
M
E
I
R
D
N
V
F
L
I
T
G
G
A
S
G
L
G
A
G
T
A
R
L
L
T
E
A
G
G
K
V
V
L
A
D
L
N
Q
D
A
G
E
A
L
A
R
E
L
G
--
G
V
F
V
R
C
D
V
A
R
E
E
D
A
Q
A
A
-
V
A
A
A
T
K
L
G
T
L
R
G
L
V
N
C
A
G
I
A
P
A
A
K
T
--
V
--
G
K
D
G
P
H
P
L
E
L
F
A
K
T
I
T
V
N
L
I
G
T
F
N
M
I
R
V
A
A
A
A
M
A
A
N
E
P
A
P
T
G
E
-
R
G
V
I
V
S
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
A
A
S
K
A
G
V
A
G
M
T
L
P
I
A
R
D
L
S
R
N
A
I
R
V
M
T
I
A
P
G
I
F
E
T
P
M
L
L
G
M
P
Q
E
V
Q
D
A
L
G
A
M
V
P
F
P
P
R
L
G
K
P
A
E
Y
A
M
L
V
R
Q
I
F
E
N
P
M
L
N
G
E
V
I
R
L
D
G
A
I
R
M
Q
P
K
32
PsiBlast_CBE
93.61
61%
-108
- C1 -
-
4XGN
3
?
E:
[9-260]
M
E
I
R
D
N
V
F
L
I
T
G
G
A
S
G
L
G
A
G
T
A
R
L
L
T
E
A
G
G
K
V
V
L
A
D
L
N
Q
D
A
G
E
A
L
A
R
E
L
G
--
G
V
F
V
R
C
D
V
A
R
E
E
D
A
Q
A
A
-
V
A
A
A
T
K
L
G
T
L
R
G
L
V
N
C
A
G
I
A
P
A
A
K
T
--
V
--
G
K
D
G
P
H
P
L
E
L
F
A
K
T
I
T
V
N
L
I
G
T
F
N
M
I
R
V
A
A
A
A
M
A
A
N
E
P
A
P
T
G
E
-
R
G
V
I
V
S
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
A
A
S
K
A
G
V
A
G
M
T
L
P
I
A
R
D
L
S
R
N
A
I
R
V
M
T
I
A
P
G
I
F
E
T
P
M
L
L
G
M
P
Q
E
V
Q
D
A
L
G
A
M
V
P
F
P
P
R
L
G
K
P
A
E
Y
A
M
L
V
R
Q
I
F
E
N
P
M
L
N
G
E
V
I
R
L
D
G
A
I
R
M
Q
P
K
28
PsiBlast_CBE
93.31
60%
-99
- C1 -
-
4PN3
1
?
B:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
S
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
M
M
A
G
M
P
Q
E
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
R
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
34
PsiBlast_CBE
92.96
61%
-107
- C1 -
-
4XGN
3
?
C:
[9-260]
M
E
I
R
D
N
V
F
L
I
T
G
G
A
S
G
L
G
A
G
T
A
R
L
L
T
E
A
G
G
K
V
V
L
A
D
L
N
Q
D
A
G
E
A
L
A
R
E
L
G
--
G
V
F
V
R
C
D
V
A
R
E
E
D
A
Q
A
A
-
V
A
A
A
T
K
L
G
T
L
R
G
L
V
N
C
A
G
I
A
P
A
A
K
T
--
V
--
G
K
D
G
P
H
P
L
E
L
F
A
K
T
I
T
V
N
L
I
G
T
F
N
M
I
R
V
A
A
A
A
M
A
A
N
E
P
A
P
T
G
E
-
R
G
V
I
V
S
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
A
A
S
K
A
G
V
A
G
M
T
L
P
I
A
R
D
L
S
R
N
A
I
R
V
M
T
I
A
P
G
I
F
E
T
P
M
L
L
G
M
P
Q
E
V
Q
D
A
L
G
A
M
V
P
F
P
P
R
L
G
K
P
A
E
Y
A
M
L
V
R
Q
I
F
E
N
P
M
L
N
G
E
V
I
R
L
D
G
A
I
R
M
Q
P
K
27
PsiBlast_CBE
92.44
60%
-100
- C1 -
-
4PN3
1
?
C:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
S
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
M
M
A
G
M
P
Q
E
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
R
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
33
PsiBlast_CBE
91.84
61%
-109
- C1 -
-
4XGN
4
?
D:
[9-260]
M
E
I
R
D
N
V
F
L
I
T
G
G
A
S
G
L
G
A
G
T
A
R
L
L
T
E
A
G
G
K
V
V
L
A
D
L
N
Q
D
A
G
E
A
L
A
R
E
L
G
--
G
V
F
V
R
C
D
V
A
R
E
E
D
A
Q
A
A
-
V
A
A
A
T
K
L
G
T
L
R
G
L
V
N
C
A
G
I
A
P
A
A
K
T
--
V
--
G
K
D
G
P
H
P
L
E
L
F
A
K
T
I
T
V
N
L
I
G
T
F
N
M
I
R
V
A
A
A
A
M
A
A
N
E
P
A
P
T
G
E
-
R
G
V
I
V
S
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
A
A
S
K
A
G
V
A
G
M
T
L
P
I
A
R
D
L
S
R
N
A
I
R
V
M
T
I
A
P
G
I
F
E
T
P
M
L
L
G
M
P
Q
E
V
Q
D
A
L
G
A
M
V
P
F
P
P
R
L
G
K
P
A
E
Y
A
M
L
V
R
Q
I
F
E
N
P
M
L
N
G
E
V
I
R
L
D
G
A
I
R
M
Q
P
K
23
PsiBlast_CBE
91.83
60%
-101
- C1 -
-
4PN3
1
?
G:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
S
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
M
M
A
G
M
P
Q
E
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
R
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
31
PsiBlast_CBE
91.76
61%
-107
- C1 -
-
4XGN
2
?
F:
[9-260]
M
E
I
R
D
N
V
F
L
I
T
G
G
A
S
G
L
G
A
G
T
A
R
L
L
T
E
A
G
G
K
V
V
L
A
D
L
N
Q
D
A
G
E
A
L
A
R
E
L
G
--
G
V
F
V
R
C
D
V
A
R
E
E
D
A
Q
A
A
-
V
A
A
A
T
K
L
G
T
L
R
G
L
V
N
C
A
G
I
A
P
A
A
K
T
--
V
--
G
K
D
G
P
H
P
L
E
L
F
A
K
T
I
T
V
N
L
I
G
T
F
N
M
I
R
V
A
A
A
A
M
A
A
N
E
P
A
P
T
G
E
-
R
G
V
I
V
S
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
A
A
S
K
A
G
V
A
G
M
T
L
P
I
A
R
D
L
S
R
N
A
I
R
V
M
T
I
A
P
G
I
F
E
T
P
M
L
L
G
M
P
Q
E
V
Q
D
A
L
G
A
M
V
P
F
P
P
R
L
G
K
P
A
E
Y
A
M
L
V
R
Q
I
F
E
N
P
M
L
N
G
E
V
I
R
L
D
G
A
I
R
M
Q
P
K
25
PsiBlast_CBE
91.76
60%
-100
- C1 -
-
4PN3
1
?
E:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
S
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
M
M
A
G
M
P
Q
E
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
R
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
117
HHSearch
91.73
61%
-104
- C1 -
-
4O5O
3
?
B:
[10-263]
-
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
G
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
-
G
G
E
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
M
M
A
G
M
P
Q
E
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
H
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
3
PsiBlast_PDB
91.61
61%
-105
- C1 -
-
4XGN
4
?
A:
[9-260]
M
E
I
R
D
N
V
F
L
I
T
G
G
A
S
G
L
G
A
G
T
A
R
L
L
T
E
A
G
G
K
V
V
L
A
D
L
N
Q
D
A
G
E
A
L
A
R
E
L
G
--
G
V
F
V
R
C
D
V
A
R
E
E
D
A
Q
A
A
-
V
A
A
A
T
K
L
G
T
L
R
G
L
V
N
C
A
G
I
A
P
A
A
K
T
--
V
--
G
K
D
G
P
H
P
L
E
L
F
A
K
T
I
T
V
N
L
I
G
T
F
N
M
I
R
V
A
A
A
A
M
A
A
N
E
P
A
P
T
G
E
-
R
G
V
I
V
S
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
A
A
S
K
A
G
V
A
G
M
T
L
P
I
A
R
D
L
S
R
N
A
I
R
V
M
T
I
A
P
G
I
F
E
T
P
M
L
L
G
M
P
Q
E
V
Q
D
A
L
G
A
M
V
P
F
P
P
R
L
G
K
P
A
E
Y
A
M
L
V
R
Q
I
F
E
N
P
M
L
N
G
E
V
I
R
L
D
G
A
I
R
M
Q
P
K
21
PsiBlast_CBE
91.30
61%
-102
- C1 -
-
4O5O
3
?
B:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
G
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
M
M
A
G
M
P
Q
E
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
H
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
29
PsiBlast_CBE
90.82
61%
-106
- C1 -
-
4XGN
7
?
H:
[9-260]
M
E
I
R
D
N
V
F
L
I
T
G
G
A
S
G
L
G
A
G
T
A
R
L
L
T
E
A
G
G
K
V
V
L
A
D
L
N
Q
D
A
G
E
A
L
A
R
E
L
G
--
G
V
F
V
R
C
D
V
A
R
E
E
D
A
Q
A
A
-
V
A
A
A
T
K
L
G
T
L
R
G
L
V
N
C
A
G
I
A
P
A
A
K
T
--
V
--
G
K
D
G
P
H
P
L
E
L
F
A
K
T
I
T
V
N
L
I
G
T
F
N
M
I
R
V
A
A
A
A
M
A
A
N
E
P
A
P
T
G
E
-
R
G
V
I
V
S
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
A
A
S
K
A
G
V
A
G
M
T
L
P
I
A
R
D
L
S
R
N
A
I
R
V
M
T
I
A
P
G
I
F
E
T
P
M
L
L
G
M
P
Q
E
V
Q
D
A
L
G
A
M
V
P
F
P
P
R
L
G
K
P
A
E
Y
A
M
L
V
R
Q
I
F
E
N
P
M
L
N
G
E
V
I
R
L
D
G
A
I
R
M
Q
P
K
24
PsiBlast_CBE
90.49
60%
-98
- C1 -
-
4PN3
1
?
F:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
S
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
-----
P
Q
E
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
R
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
2
PsiBlast_PDB
90.10
60%
-103
- C1 -
-
4PN3
1
?
A:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
S
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
M
M
A
G
M
P
Q
E
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
R
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
1
PsiBlast_PDB
89.04
61%
-101
- C1 -
-
4O5O
1
?
A:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
G
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
M
M
A
-----
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
H
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
116
HHSearch
88.93
61%
-101
- C1 -
-
4O5O
1
?
A:
[10-263]
-
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
G
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
-
G
G
E
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
P
M
M
A
-----
V
Q
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
H
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
129
HHSearch
88.46
61%
-106
- C1 -
-
4XGN
4
?
A:
[10-260]
-
E
I
R
D
N
V
F
L
I
T
G
G
A
S
G
L
G
A
G
T
A
R
L
L
T
E
A
G
G
K
V
V
L
A
D
L
N
Q
D
A
G
E
A
L
A
R
E
--
L
G
G
V
F
V
R
C
D
V
A
R
E
E
D
A
Q
A
A
V
A
A
A
-
T
K
L
G
T
L
R
G
L
V
N
C
A
G
I
A
P
A
A
K
T
--
V
--
G
K
D
G
P
H
P
L
E
L
F
A
K
T
I
T
V
N
L
I
G
T
F
N
M
I
R
V
A
A
A
A
M
A
A
N
E
P
A
P
-
T
G
E
R
G
V
I
V
S
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
A
A
S
K
A
G
V
A
G
M
T
L
P
I
A
R
D
L
S
R
N
A
I
R
V
M
T
I
A
P
G
I
F
E
T
P
M
L
L
G
M
P
Q
E
V
Q
D
A
L
G
A
M
V
P
F
P
P
R
L
G
K
P
A
E
Y
A
M
L
V
R
Q
I
F
E
N
P
M
L
N
G
E
V
I
R
L
D
G
A
I
R
M
Q
P
K
22
PsiBlast_CBE
87.53
60%
-103
- C1 -
-
4PN3
1
?
H:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
S
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
------------
D
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
R
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
26
PsiBlast_CBE
85.79
60%
-102
- C1 -
-
4PN3
1
?
D:
[9-263]
M
Q
I
E
N
R
V
F
L
I
T
G
A
G
S
G
L
G
A
A
V
S
K
M
A
V
E
A
G
A
K
V
V
L
L
D
V
N
A
E
A
G
E
A
G
A
K
A
L
G
A
S
A
R
F
Q
R
T
D
V
A
S
D
T
D
G
K
A
A
I
A
A
A
I
E
A
F
S
R
I
D
V
L
V
N
C
A
G
V
A
P
G
E
K
V
--
L
--
G
R
E
G
A
H
K
L
E
T
F
T
R
T
I
S
I
N
L
I
G
T
F
N
M
L
R
L
A
A
E
A
M
A
K
N
E
P
G
Q
G
G
E
-
R
G
V
I
I
N
T
A
S
V
A
A
F
D
G
Q
I
G
Q
A
A
Y
S
A
S
K
G
G
V
A
A
M
T
L
P
V
A
R
E
L
A
R
H
G
I
R
V
M
T
I
A
P
G
I
F
K
T
------------
A
L
G
A
S
V
P
F
P
P
R
L
G
E
P
A
E
Y
A
A
L
V
R
H
I
V
E
N
Q
M
L
N
G
E
V
I
R
L
D
G
A
L
R
M
A
A
K
40
PsiBlast_CBE
78.31
50%
-54
- C1 -
-
1E6W
1
HCD2_RAT
D:
[6-258]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
L
L
T
T
L
P
D
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
43
PsiBlast_CBE
77.11
50%
-52
- C1 -
-
1E3W
3
HCD2_RAT
D:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
L
L
T
T
L
P
D
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
6
PsiBlast_PDB
75.57
52%
-50
- C1 -
-
1U7T
1
HCD2_HUMAN
A:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
A
T
A
E
R
L
V
G
Q
G
A
S
A
V
L
L
D
L
P
N
S
G
G
E
A
Q
A
K
K
L
G
N
N
C
V
F
A
P
A
D
V
T
S
E
K
D
V
Q
T
A
L
A
L
A
K
G
K
F
G
R
V
D
V
A
V
N
C
A
G
I
A
V
A
S
K
T
YN
L
--
K
K
G
Q
T
H
T
L
E
D
F
Q
R
V
L
D
V
N
L
M
G
T
F
N
V
I
R
L
V
A
G
E
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
M
T
I
A
P
G
L
F
G
T
P
L
L
T
S
L
P
E
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
A
I
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
37
PsiBlast_CBE
74.85
52%
-51
- C1 -
-
1U7T
1
HCD2_HUMAN
D:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
A
T
A
E
R
L
V
G
Q
G
A
S
A
V
L
L
D
L
P
N
S
G
G
E
A
Q
A
K
K
L
G
N
N
C
V
F
A
P
A
D
V
T
S
E
K
D
V
Q
T
A
L
A
L
A
K
G
K
F
G
R
V
D
V
A
V
N
C
A
G
I
A
V
A
S
K
T
YN
L
--
K
K
G
Q
T
H
T
L
E
D
F
Q
R
V
L
D
V
N
L
M
G
T
F
N
V
I
R
L
V
A
G
E
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
M
T
I
A
P
G
L
F
G
T
P
L
L
T
S
L
P
E
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
A
I
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
39
PsiBlast_CBE
74.53
52%
-52
- C1 -
-
1U7T
1
HCD2_HUMAN
B:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
A
T
A
E
R
L
V
G
Q
G
A
S
A
V
L
L
D
L
P
N
S
G
G
E
A
Q
A
K
K
L
G
N
N
C
V
F
A
P
A
D
V
T
S
E
K
D
V
Q
T
A
L
A
L
A
K
G
K
F
G
R
V
D
V
A
V
N
C
A
G
I
A
V
A
S
K
T
YN
L
--
K
K
G
Q
T
H
T
L
E
D
F
Q
R
V
L
D
V
N
L
M
G
T
F
N
V
I
R
L
V
A
G
E
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
M
T
I
A
P
G
L
F
G
T
P
L
L
T
S
L
P
E
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
A
I
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
41
PsiBlast_CBE
74.45
50%
-58
- C1 -
-
1E6W
2
HCD2_RAT
C:
[6-258]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
L
L
T
-------
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
45
PsiBlast_CBE
74.41
50%
-58
- C1 -
-
1E3W
2
HCD2_RAT
B:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
L
L
T
--------
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
9
PsiBlast_PDB
73.48
50%
-59
- C1 -
-
1E3W
2
HCD2_RAT
A:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
L
L
T
----
T
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
38
PsiBlast_CBE
72.92
52%
-49
- C1 -
-
1U7T
1
HCD2_HUMAN
C:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
A
T
A
E
R
L
V
G
Q
G
A
S
A
V
L
L
D
L
P
N
S
G
G
E
A
Q
A
K
K
L
G
N
N
C
V
F
A
P
A
D
V
T
S
E
K
D
V
Q
T
A
L
A
L
A
K
G
K
F
G
R
V
D
V
A
V
N
C
A
G
I
A
V
A
S
K
T
YN
L
--
K
K
G
Q
T
H
T
L
E
D
F
Q
R
V
L
D
V
N
L
M
G
T
F
N
V
I
R
L
V
A
G
E
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
M
T
I
A
P
G
L
F
G
T
P
L
L
T
S
L
P
E
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
A
I
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
10
PsiBlast_PDB
72.79
50%
-57
- C1 -
-
1E6W
1
HCD2_RAT
A:
[6-258]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
L
L
T
----
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
47
PsiBlast_CBE
72.60
50%
-62
- C1 -
-
1E3S
1
HCD2_RAT
C:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
--------------
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
42
PsiBlast_CBE
72.50
50%
-64
- C1 -
-
1E6W
1
HCD2_RAT
B:
[6-258]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
L
L
T
--------
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
44
PsiBlast_CBE
72.46
50%
-58
- C1 -
-
1E3W
3
HCD2_RAT
C:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
L
L
T
-------
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
11
PsiBlast_PDB
72.43
50%
-60
- C1 -
-
1E3S
1
HCD2_RAT
A:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
--------------
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
48
PsiBlast_CBE
71.10
50%
-59
- C1 -
-
1E3S
1
HCD2_RAT
B:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
--------------
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
8
PsiBlast_PDB
71.01
52%
-56
- C1 -
-
2O23
2
HCD2_HUMAN
A:
[9-261]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
A
T
A
E
R
L
V
G
Q
G
A
S
A
V
L
L
D
L
P
N
S
G
G
E
A
Q
A
K
K
L
G
N
N
C
V
F
A
P
A
D
V
T
S
E
K
D
V
Q
T
A
L
A
L
A
K
G
K
F
G
R
V
D
V
A
V
N
C
A
G
I
A
V
A
S
K
T
YN
L
--
K
K
G
Q
T
H
T
L
E
D
F
Q
R
V
L
D
V
N
L
M
G
T
F
N
V
I
R
L
V
A
G
E
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
M
T
I
A
P
G
L
F
G
T
P
----------
N
F
L
A
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
A
I
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---
46
PsiBlast_CBE
70.51
50%
-60
- C1 -
-
1E3S
1
HCD2_RAT
D:
[7-259]
-
S
V
K
G
L
V
A
V
I
T
G
G
A
S
G
L
G
L
S
T
A
K
R
L
V
G
Q
G
A
T
A
V
L
L
D
V
P
N
S
E
G
E
T
E
A
K
K
L
G
G
N
C
I
F
A
P
A
N
V
T
S
E
K
E
V
Q
A
A
L
T
L
A
K
E
K
F
G
R
I
D
V
A
V
N
C
A
G
I
A
V
A
I
K
T
--
Y
HE
K
K
N
Q
V
H
T
L
E
D
F
Q
R
V
I
N
V
N
L
I
G
T
F
N
V
I
R
L
V
A
G
V
M
G
Q
N
E
P
D
Q
G
G
Q
-
R
G
V
I
I
N
T
A
S
V
A
A
F
E
G
Q
V
G
Q
A
A
Y
S
A
S
K
G
G
I
V
G
M
T
L
P
I
A
R
D
L
A
P
I
G
I
R
V
V
T
I
A
P
G
L
F
A
T
P
--------------
S
Q
V
P
F
P
S
R
L
G
D
P
A
E
Y
A
H
L
V
Q
M
V
I
E
N
P
F
L
N
G
E
V
I
R
L
D
G
A
I
R
M
---