@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM30: (2017-11-05 )
MILNAEQSMVQEMMRNYAQNQLKPTAAHRDKTHEFPAQELKDLGALGAMGMTVPDEWGGAGMDYVSLVLAIEEIAAGDGAISTIVSVQNSLICGITLAYGSEQQKQTYLPKFASGEWLGCFCLTEPHVGSDASAILCKAERDGDHWILNGVKQFITSGKNAQVALVFAVTDKQAGKKGISCFLVPTNTQGYLVTRIEDKMGQHASDTATITLEDCRIPLENLVGQEGEGYKIALSNLAAGRIGIAAQSVGMARAAFDAAVQYANERKAFGVELVQHQAVGFRLADMATQIEAAHQLVLHAATLKDAGLPCLKEASMAKLFASTMAERVCSDAIQIHGGYGYVSDFPVERIYRDVRVSQIYEGASDIQRLVIAREVAQV
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140........150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MILN
A
E
Q
S
M
V
Q
E
M
M
R
N
Y
A
Q
NQLKPTAAHRDKTHEF
P
A
Q
E
L
K
D
L
GALGAMGMTVPDEWGGA
G
M
D
Y
V
S
L
V
L
A
I
E
E
IAAGD
G
A
I
S
T
I
V
S
VQNS
L
I
C
G
I
T
L
AYGSE
Q
Q
K
Q
TYLPKFASG
E
W
L
G
C
F
C
LTEPHVGSDA
S
A
I
L
C
K
AE-RDGD
H
W
I
L
N
G
V
K
Q
F
I
TSGKN
A
Q
V
A
L
V
F
A
VTDKQAGKKG
I
S
C
F
L
V
PTNTQ
G
Y
L
V
T
R
I
E
D
K
MGQHASD
T
A
T
I
T
L
E
DCRI
P
L
E
N
LVGQEGE
G
Y
K
I
A
L
S
NLAAGRI
G
I
A
A
Q
S
V
G
M
A
R
A
A
F
D
A
A
V
Q
Y
ANERK
A
F
G
V
E
L
V
Q
HQAV
G
F
R
L
A
D
M
A
T
Q
I
E
A
A
H
Q
L
V
L
H
A
ATLKDAG
L
P
C
L
K
E
A
S
M
A
K
L
F
A
S
T
M
A
E
R
V
C
S
D
A
I
Q
IHGGYGYVSDF
P
V
E
R
I
Y
R
D
V
R
V
S
Q
I
Y
E
G
A
S
D
I
Q
R
L
V
I
A
R
E
V
AQV
115
HHSearch
94.46
57%
-94
- C2 -
-
4N5F
2
?
A:
[13-385]
--
Y
T
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
D
Y
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
-
L
R
D
G
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
E
A
G
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---
1
PsiBlast_PDB
94.32
63%
-96
- C2 -
-
4U83
1
?
A:
[8-380]
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
D
M
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
R
-
L
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
A
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
-----
23
PsiBlast_CBE
93.73
63%
-95
- C2 -
-
4U83
5
?
B:
[8-380]
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
D
M
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
R
-
L
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
A
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
-----
21
PsiBlast_CBE
93.50
63%
-93
- C2 -
-
4U83
2
?
D:
[8-380]
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
D
M
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
R
-
L
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
A
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
------
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
-----
22
PsiBlast_CBE
93.03
63%
-93
- C2 -
-
4U83
1
?
C:
[8-380]
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
D
M
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
R
-
L
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
A
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
-----
7
PsiBlast_PDB
91.49
49%
-92
- C2 -
-
2DVL
2
?
A:
[3-370]
--
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
P
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
D
S
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
R
-
R
V
K
G
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
K
-----
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
---
36
PsiBlast_CBE
91.30
49%
-94
- C2 -
-
2DVL
2
?
B:
[3-370]
--
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
P
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
D
S
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
R
-
R
V
K
G
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
K
-----
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
---
117
HHSearch
89.94
55%
-95
- C2 -
-
4M9A
1
?
A:
[13-384]
--
Y
T
E
D
Q
R
M
I
L
D
A
A
R
A
F
C
A
E
V
L
A
P
N
A
A
Q
W
D
R
E
S
H
L
P
D
E
V
V
A
Q
M
G
E
L
G
F
L
G
M
I
V
P
A
D
W
G
G
S
Y
T
D
Y
V
A
Y
A
L
A
L
E
E
I
A
A
G
C
A
S
C
A
T
L
V
S
V
H
N
S
V
G
C
G
P
V
L
N
Y
G
T
T
E
Q
K
E
R
W
L
R
D
L
A
S
G
K
T
V
G
A
F
S
L
T
E
P
H
-----
H
N
L
R
T
R
A
E
-
L
R
D
G
K
W
I
L
N
G
S
K
Q
F
V
T
N
G
A
R
A
G
L
A
I
V
F
A
M
T
D
P
D
E
G
K
R
G
L
S
A
F
V
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
L
E
N
C
A
I
P
Q
E
N
L
L
G
K
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
T
G
I
A
R
A
A
F
D
R
A
R
R
Y
A
R
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
A
E
K
L
A
N
M
A
T
Q
I
N
A
A
R
L
L
T
H
H
A
A
R
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
A
V
C
S
D
A
I
Q
I
H
G
G
Y
G
F
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
----
31
PsiBlast_CBE
89.57
48%
-91
- C2 -
-
2VIG
5
ACADS_HUMAN
E:
[6-375]
--
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
A
L
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------
121
HHSearch
89.13
48%
-90
* C2 *
-
2VIG
5
ACADS_HUMAN
A:
[6-380]
--
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
A
L
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
-
34
PsiBlast_CBE
88.57
48%
-95
- C2 -
-
2VIG
6
ACADS_HUMAN
B:
[6-375]
--
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
-------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------
5
PsiBlast_PDB
87.93
48%
-91
- C2 -
-
2VIG
5
ACADS_HUMAN
A:
[6-375]
--
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
A
L
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------
29
PsiBlast_CBE
87.68
48%
-93
- C2 -
-
2VIG
7
ACADS_HUMAN
G:
[6-375]
--
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
---
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------
120
HHSearch
87.65
48%
-80
- C2 -
-
1JQI
4
ACADS_RAT
A:
[9-384]
-
E
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
R
Q
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
-
2
PsiBlast_PDB
87.33
57%
-50
- C2 -
-
4N5F
2
?
A:
[16-385]
-----
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
D
Y
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
L
R
D
G
-
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
E
A
G
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---
32
PsiBlast_CBE
86.73
48%
-90
- C2 -
-
2VIG
6
ACADS_HUMAN
D:
[6-375]
--
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
-----
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------
27
PsiBlast_CBE
86.31
49%
-84
- C2 -
-
1JQI
4
ACADS_RAT
B:
[16-379]
--------
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
R
Q
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------
30
PsiBlast_CBE
86.24
48%
-91
- C2 -
-
2VIG
9
ACADS_HUMAN
F:
[6-375]
--
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
------
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------
35
PsiBlast_CBE
86.09
46%
-86
- C2 -
-
4L1F
4
?
B:
[5-375]
--
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
-
L
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
Q
G
V
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
-----
28
PsiBlast_CBE
85.99
48%
-89
- C2 -
-
2VIG
6
ACADS_HUMAN
H:
[6-375]
--
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
------
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------
4
PsiBlast_PDB
85.63
49%
-83
- C2 -
-
1JQI
4
ACADS_RAT
A:
[16-379]
--------
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
-
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
R
Q
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------
24
PsiBlast_CBE
81.99
57%
-52
- C2 -
-
4N5F
2
?
B:
[16-385]
-----
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
D
Y
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
-------
L
R
T
R
A
E
L
R
D
---
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
E
A
G
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---