@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM31: (2017-11-05 )
MKTLAEAYRQFDLTRLIEEQLVGHPQAINAYVECCERYVGKNKTALIWEGKNGQAEYYTFEQLAELSGKLANFFKAQGIQAGDCIAGLLPRTPELLITILAAWRIGAIYQPLFTAFEAKSIDHRITTAQTKLIVTNDEQRPKLNSLNVPVIVTVHQTGLLSEHDFDFWQSLQRYSEQCEPVNRSVDDDFLMMFTSGTTGLAKSVPVPLKAILAFKGYMTHAVDLREEDMFWNLADPGWAYGLYYGITGPLSLGHSIIMDERSFNVDQAMELIKKYKVSNLTGSPTAFRMFFGFKEKFDPSIKQHLRVVSSAGEPLTPEVVNWFKQDLEVNIFDQYGQTELGMVIANHHALEHPLKVGSAGFAIPGHRFAVLDQNYQELPTGGVGILAMDSEQSPLMWFKGYGGNNRKSFVGKYYLTGDTVTLNEHGGIGFVGRADDVITTSGYRVGPFDVESTLLECEAVLESAVIGKPDPERTEIVKAFVVLKPAYQACETLKDKLQQYVRNRLSRHAYPKEIEFVDSLPKTTSGKIQRGLLKQQEIAKMQPYAS
Atome Classification :
(21 SA)
.........10........20.....-...30........--40--.--.......50.-.......60........70....-....80........90........100.......110.......120.......130...--...-------------------.140......-.----.---------------.150-----......-.160--......---------...170-.-.-.----..--...180------......----...190.......200..----.....210........-220.-------.......230.......240.......250....-...-260.---.---...---...270.......280.......290....-.-..300..----.....310.......320.....---.---.330.......340-........350........360.......370.--..-....380.-......390..-.-..---..--..400..---..--...------410-...---......420.......430.......440.......450.......460.......470.......480......--.--490.......500-----.........510.......520.......530.......540....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
T
L
A
E
A
Y
R
Q
F
D
L
T
R
L
I
E
E
Q
LVGH
P
Q
-
A
I
N
A
Y
V
E
C
C
E
R
Y
V--GK--N--
K
T
A
L
I
W
EGKN-GQ
A
E
Y
Y
T
F
E
Q
L
A
E
L
S
G
K
L
A
N
F
F
K
-AQGIQA
G
D
C
I
A
G
LLPR
T
P
E
L
L
I
T
I
L
A
A
W
R
I
G
A
I
Y
Q
P
L
F
T
A
F
E
AKSIDHRITT
A
Q
T
K
L
I
V
T--NDE-------------------QR--PKLNSL-N----V---------------
P
V
I
V
-----
T
V
HQTG-LL----SEH
D
F
D
---------
F
W
Q
S
-
L
-
Q
-
R
-
Y
----
S
E
--QCEP--------VNRSVD----D
D
F
L
M
M
FTSGTTGLAKSV----P
V
P
L
K
A
-
I
L
A
FKGY
M
T
-
H
A
-
V
-------DLREED
M
F
W
NLADPGWA
Y
G
L
Y
YGIT
G
P
L
SLG
H
S
I
-
I
MD-ER-S---F---
N
V
D
---
Q
A
M
E
L
I
K
K
YKVSNLTGS
P
T
A
F
R
M
F
FG
F
K
E
K-F-
D
P
S
I
K
Q
H
----
L
R
V
V
S
SAGEPL
T
P
E
V
V
N
W
F
K
QDL---
E
---
V
N
I
F
DQYGQ
T
E
L
G
--
M
V
I
ANHHALE-HPLKVGSAGFAIPG
H
R
F
A
V
LDQ--
N
Y
-
Q
ELPTG
G
V
-
G
I
L
A
MDS--EQ-S-
P
L
---
M
W
--
F
KGYGGN---NR--
K
S
F
------
V
---
G
K
Y
---
Y
LTG
D
T
V
T
LNEHGG
I
G
FVGRAD
D
V
I
TTSG
Y
R
VG
P
F
D
V
E
S
T
L
L
E
C
E
A
V
L
E
S
AVIGKPD
P
E
R
T
E
I
V
K
A
F
V
VL
K
P
A
Y
Q
--
A
--
C
E
T
L
K
D
K
L
Q
Q
Y
-------
V
R
N
R
L
S
RHAYP
K
E
I
E
F
V
D
SLPKTTS
G
K
I
Q
R
G
L
L
K
Q
Q
E
I
A
KMQPYAS
1
PsiBlast_PDB
86.48
52%
-22
- C1 -
-
5U2A
-
?
A:
[23-561]
-----
D
A
V
A
Q
F
D
I
A
K
A
I
A
-
L
L
A
G
N
P
D
T
G
I
N
A
C
I
E
C
C
D
R
Y
T
--
G
E
--
N
--
R
V
A
L
R
A
I
S
I
D
-
N
T
L
T
E
L
T
F
E
D
L
R
D
M
S
A
R
V
G
N
M
L
A
-
D
A
G
I
S
A
G
D
V
V
A
G
L
L
P
R
T
P
E
L
V
A
T
I
L
G
A
W
R
I
G
A
I
Y
Q
P
L
F
T
A
F
G
P
K
A
I
E
Q
R
F
G
T
S
G
A
K
L
V
V
T
--
N
L
A
-------------------
N
R
--
S
K
L
A
E
V
E
N
----
C
---------------
P
R
V
A
-----
T
I
L
A
P
G
E
S
L
----
P
E
G
D
I
D
---------
F
R
A
A
-
V
-
A
-
A
-
A
----
S
T
--
E
C
E
P
--------
V
M
R
K
G
S
----
D
L
F
M
M
M
S
T
S
G
T
A
--
P
K
G
V
----
P
V
P
L
R
A
-
L
M
A
F
G
A
Y
M
R
-
D
A
-
V
-------
G
L
R
S
D
D
I
F
W
N
I
A
D
P
G
W
A
Y
G
L
Y
Y
A
V
T
G
P
L
L
L
G
V
P
T
-
I
L
N
-
E
G
-
G
---
F
---
T
A
E
---
N
T
Y
D
I
I
E
R
L
G
V
T
S
L
A
G
S
P
T
A
F
R
L
L
I
A
A
G
P
E
-
S
-
A
A
R
V
K
G
R
----
L
R
V
V
S
S
A
G
E
P
L
N
P
E
V
I
R
W
F
D
A
C
L
---
G
---
A
P
I
H
D
H
Y
G
Q
T
E
L
G
--
M
V
V
N
N
H
H
G
L
E
-
H
P
V
R
Q
G
S
A
G
Y
A
M
P
G
Y
R
V
A
V
L
D
E
--
A
G
-
K
E
V
G
P
N
E
P
-
G
V
L
A
I
D
I
--
D
N
-
S
-
P
L
---
L
W
--
F
T
G
Y
Y
K
K
---
D
T
--
P
S
I
------
S
---
G
G
Y
---
Y
R
T
G
D
T
V
E
F
E
P
D
G
S
I
S
F
I
G
R
A
D
D
V
I
T
S
S
G
Y
R
I
G
P
F
D
V
E
S
A
L
L
K
H
P
A
V
N
E
A
A
V
V
G
V
P
D
P
Q
R
T
E
I
V
K
A
F
V
I
L
A
P
G
F
E
--
G
--
T
P
E
L
A
E
E
L
A
L
H
-------
V
K
K
Q
L
S
A
H
A
Y
P
R
Q
I
D
F
V
A
E
L
P
K
T
P
S
G
K
I
Q
R
F
L
L
R
K
A
E
V
E
K
Q
Q
----
27
HHSearch
82.13
52%
-26
- C1 -
-
5U2A
-
?
A:
[45-558]
----------------------------
I
N
A
C
I
E
C
C
D
R
Y
T
--
G
E
--
N
--
R
V
A
L
R
A
I
S
I
D
-
N
T
L
T
E
L
T
F
E
D
L
R
D
M
S
A
R
V
G
N
M
L
A
-
D
A
G
I
S
A
G
D
V
V
A
G
L
L
P
R
T
P
E
L
V
A
T
I
L
G
A
W
R
I
G
A
I
Y
Q
P
L
F
T
A
F
G
P
K
A
I
E
Q
R
F
G
T
S
G
A
K
L
V
V
T
--
N
L
A
-------------------
N
R
--
S
K
L
A
E
V
-
E
----
N
C
P
R
------------
V
A
T
I
-----
L
A
P
G
E
S
-
L
-----
P
-
E
G
D
I
---------
D
F
R
A
-
A
-
V
A
A
-
A
----
S
T
--
E
C
E
P
--------
V
M
R
K
G
S
----
D
L
F
M
M
M
S
T
S
G
T
A
--
P
K
G
V
----
P
V
P
L
R
A
-
L
M
A
F
G
A
Y
M
R
-
D
A
-
V
-------
G
L
R
S
D
D
I
F
W
N
I
A
D
P
G
W
A
Y
G
L
Y
Y
A
V
T
G
P
L
L
L
G
V
P
T
-
I
L
N
-
E
G
-
G
---
F
---
T
A
E
---
N
T
Y
D
I
I
E
R
L
G
V
T
S
L
A
G
S
P
T
A
F
R
L
L
I
A
A
G
P
E
-
S
-
A
A
R
V
K
G
R
----
L
R
V
V
S
S
A
G
E
P
L
N
P
E
V
I
R
W
F
D
A
C
L
---
G
---
A
P
I
H
D
H
Y
G
Q
T
E
L
G
--
M
V
V
N
N
H
H
G
L
E
-
H
P
V
R
Q
G
S
A
G
Y
A
M
P
G
Y
R
V
A
V
L
D
E
--
A
G
-
K
E
V
G
P
N
E
P
-
G
V
L
A
I
D
I
--
D
N
-
S
-
P
L
---
L
W
--
F
T
G
Y
Y
K
K
---
D
T
--
P
S
I
------
S
---
G
G
Y
---
Y
R
T
G
D
T
V
E
F
E
P
D
G
S
I
S
F
I
G
R
A
D
D
V
I
T
S
S
G
Y
R
I
G
P
F
D
V
E
S
A
L
L
K
H
P
A
V
N
E
A
A
V
V
G
V
P
D
P
Q
R
T
E
I
V
K
A
F
V
I
L
A
P
G
F
E
--
G
--
T
P
E
L
A
E
E
L
A
L
H
-------
V
K
K
Q
L
S
A
H
A
Y
P
R
Q
I
D
F
V
A
E
L
P
K
T
P
S
G
K
I
Q
R
F
L
L
R
K
A
E
V
E
-------
10
PsiBlast_PDB
75.41
31%
0
- C- -
-
1RY2
1
ACS1_YEAST
A:
[81-646]
----------------------------
L
N
A
C
Y
N
C
V
D
R
H
A
--
L
K
TP
N
--
K
K
A
I
I
F
E
G
D
E
P
G
Q
G
Y
S
I
T
Y
K
E
L
L
E
E
V
C
Q
V
A
Q
V
L
T
Y
S
M
G
V
R
K
G
D
T
V
A
V
Y
M
P
M
V
P
E
A
I
I
T
L
L
A
I
S
R
I
G
A
I
H
S
V
V
F
A
G
F
S
S
N
S
L
R
D
R
I
N
D
G
D
S
K
V
V
I
T
--
T
D
E
S
N
R
GG
K
V
I
E
T
K
R
I
V
D
D
A
L
R
E
T
--
P
G
V
R
H
V
-
L
----
V
---------------
Y
R
K
T
-----
N
N
P
S
V
A
-
F
H
----
A
P
R
D
L
D
---------
W
A
T
E
-
K
-
K
-
K
-
Y
----
K
T
Y
Y
P
C
T
P
--------
V
D
S
--
E
----
D
P
L
F
L
L
Y
T
S
G
S
T
G
A
P
K
G
V
----
Q
H
S
T
A
G
Y
L
L
G
A
L
L
T
M
R
-
Y
T
-
F
-------
D
T
H
Q
E
D
V
F
F
T
A
G
D
I
G
W
I
T
G
H
T
Y
V
V
Y
G
P
L
L
Y
G
C
A
T
-
L
V
F
-
E
G
-
T
---
P
AYP
N
Y
S
---
R
Y
W
D
I
I
D
E
H
K
V
T
Q
F
Y
V
A
P
T
A
L
R
L
L
---
K
R
A
-
G
-
D
S
Y
I
E
N
H
SLKS
L
R
C
L
G
S
V
G
E
P
I
A
A
E
V
W
E
W
Y
S
E
K
I
GKN
E
---
I
P
I
V
D
T
Y
W
Q
T
E
S
G
--
S
H
L
V
T
P
L
A
G
G
V
T
P
M
K
P
G
S
A
S
F
P
F
F
G
I
D
A
V
V
L
D
P
--
N
T
G
E
E
L
N
T
S
H
A
E
G
V
L
A
V
K
A
--
A
W
-
P
-
S
F
ART
I
W
KN
H
D
R
Y
L
D
T
---
Y
L
--
N
P
Y
------
P
---
G
-
Y
---
Y
F
T
G
D
G
A
A
K
D
K
D
G
Y
I
W
I
L
G
R
V
D
D
V
V
N
V
S
G
H
R
L
S
T
A
E
I
E
A
A
I
I
E
D
P
I
V
A
E
C
A
V
V
G
F
N
D
D
L
T
G
Q
A
V
A
A
F
V
V
L
K
----------------
L
Q
D
I
K
K
H
L
V
F
T
V
R
K
D
I
G
P
F
A
A
P
K
L
I
I
L
V
D
D
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
31
HHSearch
70.18
27%
-30
- C1 -
-
2P20
1
ACSA_SALTY
A:
[105-623]
--------------------------------------------------------------
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
--
A
D
E
-------------------
G
V
--
R
A
G
R
S
I
-
P
----
L
K
K
N
V
D
D
A
L
K
NPNVTS
V
E
H
V
-----
I
V
L
K
R
T
-
G
S
D
I
D
W
Q
E
G
R
D
L
---------
W
W
R
D
-
L
-
I
-
E
K
A
----
S
P
--
E
H
Q
P
--------
E
A
M
N
A
E
----
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
----
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
F
K
Y
V
-
F
-------
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
-
L
M
F
-
E
G
-
V
PNW
P
---
T
P
A
---
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
-
A
I
E
G
T
D
R
S
S
----
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
G
--
G
F
M
I
T
P
L
P
G
A
-
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
--
E
G
-
H
P
Q
E
G
A
T
E
-
G
N
L
V
I
T
D
SW
P
G
---------
Q
--
A
R
T
L
F
G
D
---
H
E
--
R
F
E
Q
T
YFST
F
---
K
N
M
---
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
--
S
P
E
L
Y
A
E
V
R
N
W
-------
V
A
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
G
-------
38
HHSearch
69.01
31%
3
* C1 *
-
3B7W
1
ACS2A_HUMAN
A:
[56-562]
------------------------------------------
R
P
--
P
--
S
P
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
-
A
SECP
S
---------------
L
R
I
K
-----
L
L
V
S
E
K
-------
S
C
D
G
W
L
---------
N
F
K
K
-
L
-
L
-
N
E
A
----
S
T
--
T
H
H
C
--------
V
E
T
G
S
Q
----
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
D
A
-
G
W
-
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
L
L
P
-
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
L
S
----
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
---
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
-
I
R
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
A
N
I---
R
---
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
SH
D
--
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
2
PsiBlast_PDB
67.77
30%
8
- C1 -
-
3ETC
10
?
A:
[34-559]
-
K
T
D
F
E
S
Y
E
D
F
Q
-----
E
N
F
K
I
L
V
P
E
-
N
F
N
F
A
Y
D
V
V
D
V
Y
A
R
D
S
P
--
E
--
K
L
A
M
I
W
C
D
D
Y
-
G
N
E
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
A
E
D
D
-------------------
V
P
--
E
Q
V
D
E
A
-
H
----
A
---------------
E
C
G
D
-----
I
P
L
K
K
A
-
K
V
----
G
G
D
V
L
E
---------
G
W
I
D
-
F
-
R
-
K
-
E
----
L
E
--
E
S
S
P
IFERPTGE
V
S
T
K
N
E
----
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
EHDN
T
Y
P
L
G
H
-
I
L
T
A
K
Y
W
Q
-------------
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
Y
D
-
Y
D
-
R
---
F
---
E
A
K
---
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
--
F
L
I
K
E
D
-
L
----
N
F
S
T
----
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
---
I
K
L
M
E
G
F
G
Q
T
E
T
V
--
V
T
I
A
T
F
P
W
M
E
-
P
--
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
--
D
G
-
R
L
C
E
V
G
E
E
-
G
E
I
V
I
N
T
M-
E
G
-
K
-
P
V
---
G
L
--
F
V
H
Y
G
K
D
P
E
R
T
E
--
E
T
W
------
H
---
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
--
P
--
S
D
S
L
K
N
E
L
Q
D
H
-------
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
---------------------------
14
PsiBlast_PDB
67.54
27%
-1
- C1 -
-
2P2M
1
ACSA_SALTY
A:
[75-622]
----------------------------
L
N
L
A
A
N
C
L
D
R
H
L
--
Q
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
--
A
D
E
G
V
R
AGASIP
L
---------
K
K
--
N
V
D
D
A
L
-
K
----
N
---------------
P
N
V
T
-----
S
V
E
H
V
I
-
V
L
----
K
R
T
G
S
D
I
D
W
Q
E
GRDL
W
W
R
D
-
L
I
E
-
K
-
A
----
S
P
--
E
H
Q
P
--------
E
A
M
N
A
E
----
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
-----------
L
H
T
T
G
G
Y
L
V
-
Y
A
-
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
-
L
M
F
-
E
G
-
V
---
P
---
N
W
P
TPA
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
-
E
G
T
D
R
S
S
----
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
GKE
K
---
C
P
V
V
D
T
W
W
Q
T
E
T
G
GF
M
I
T
P
L
P
G
A
I
E
---
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
EG
H
P
-
Q
E
G
A
T
E
G
N
-
L
V
I
---
T
--
D
S
-
W
-
P
G
---
Q
A
--
R
T
L
F
G
D
H
---
E
R
F
E
Q
T
Y
------
F
---
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
--
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
4
PsiBlast_PDB
67.14
31%
-1
- C1 -
-
3B7W
1
ACS2A_HUMAN
A:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
N
IR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------
37
HHSearch
66.97
31%
3
- C1 -
-
3C5E
4
ACS2A_HUMAN
A:
[56-562]
------------------------------------------
R
P
--
P
--
S
P
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
-
A
SECP
S
---------------
L
R
I
K
-----
L
L
V
S
E
K
-------
S
C
D
G
W
L
---------
N
F
K
K
-
L
-
L
-
N
E
A
----
S
T
--
T
H
H
C
--------
V
E
T
G
S
Q
----
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
-
L
G
L
K
A
K
M
D
A
-
G
W
-
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
L
L
P
-
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
L
S
----
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
---
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
-
I
R
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
A
N
I---
R
---
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
SH
D
--
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
12
PsiBlast_PDB
66.80
27%
-1
- C1 -
-
5JRH
6
ACSA_SALTY
A:
[75-620]
----------------------------
L
N
L
A
A
N
C
L
D
R
H
L
--
Q
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
--
A
D
E
G
V
R
AGRSIP
L
---------
K
K
--
N
V
D
D
A
L
-
K
----
N
---------------
P
N
V
T
-----
S
V
E
H
V
I
-
V
L
----
K
R
T
G
S
D
I
D
W
Q
E
GRDL
W
W
R
D
-
L
I
E
-
K
-
A
----
S
P
--
E
H
Q
P
--------
E
A
M
N
A
E
----
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
-----------
L
H
T
T
G
G
Y
L
V
-
Y
A
-
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
-
L
M
F
-
E
G
-
V
---
P
---
N
W
P
TPA
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
-
E
G
T
D
R
S
S
----
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
GKE
K
---
C
P
V
V
D
T
W
W
Q
T
E
T
G
GF
M
I
T
P
L
P
G
A
I
E
---
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
EG
H
P
-
Q
E
G
A
T
E
G
N
-
L
V
I
---
T
--
D
S
-
W
-
P
G
---
Q
A
--
R
T
L
F
G
D
H
---
E
R
F
E
Q
T
Y
------
F
---
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
--
S
P
E
L
Y
A
E
V
R
N
W
-------
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
24
PsiBlast_CBE
66.68
31%
-1
- C1 -
-
3EQ6
2
ACS2A_HUMAN
B:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
NIR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------
7
PsiBlast_PDB
66.65
31%
-0
- C1 -
-
2VZE
1
ACS2A_HUMAN
A:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
N
IR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------
6
PsiBlast_PDB
66.40
31%
-1
- C1 -
-
3DAY
3
ACS2A_HUMAN
A:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
N
IR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
--
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------
28
HHSearch
66.39
31%
-5
- C1 -
-
3ETC
8
?
B:
[70-562]
-------------------------------------------
P
--
E
--
K
L
A
M
I
W
C
D
D
Y
-
G
N
E
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
--
I
A
E
-------------------
D
D
V
P
E
Q
V
D
E
A
-
H
----
A
---------------
E
C
G
D
IP
L
K
K
A
K
V
G
G
D
-
V
L
------
E
G
W
I
---------
D
F
R
K
E
L
-
E
-
E
-
S
SPIF
E
R
--
P
T
G
E
--------
V
S
T
K
N
E
----
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
----
E
H
D
N
T
Y
-
P
L
G
H
I
L
T
A
K
-
Y
W
-
Q
-------
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
-
F
V
Y
-
D
Y
D
R
---
F
---
E
A
K
---
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
F
L
I
K
E
D
L
S
-
H
---
Y
N
F
S
T
----
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
---
I
K
L
M
E
G
F
G
Q
T
E
T
V
--
V
T
I
A
T
F
P
W
M
---
E
P
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
--
D
G
-
R
L
C
E
V
G
E
E
-
G
E
I
V
I
N
T
--
M
E
-
G
K
P
V
---
G
L
--
F
V
H
Y
G
K
D
---
P
E
--
R
T
E
E
T
W
---
H
---
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
--
P
--
S
D
S
L
K
N
E
L
Q
D
H
-------
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
L
P
K
------------------------
25
PsiBlast_CBE
66.38
31%
-0
- C1 -
-
2VZE
1
ACS2A_HUMAN
C:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
NIR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------
17
PsiBlast_PDB
66.37
27%
-2
- C1 -
-
2P20
1
ACSA_SALTY
A:
[75-619]
----------------------------
L
N
L
A
A
N
C
L
D
R
H
L
--
Q
E
--
N
GD
R
T
A
I
I
W
E
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
--
A
D
E
G
V
R
AGRSIP
L
---------
K
K
--
N
V
D
D
A
L
-
K
----
N
---------------
P
N
V
T
-----
S
V
E
H
V
I
-
V
L
----
K
R
T
G
S
D
I
D
W
Q
E
GRDL
W
W
R
D
-
L
I
E
-
K
-
A
----
S
P
--
E
H
Q
P
--------
E
A
M
N
A
E
----
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
-----------
L
H
T
T
G
G
Y
L
V
-
Y
A
-
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
-
L
M
F
-
E
G
-
V
---
P
---
N
W
P
TPA
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
-
E
G
T
D
R
S
S
----
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
GKE
K
---
C
P
V
V
D
T
W
W
Q
T
E
T
G
GF
M
I
T
P
L
P
G
A
I
E
---
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
EG
H
P
-
Q
E
G
A
T
E
G
N
-
L
V
I
---
T
--
D
S
-
W
-
P
G
---
Q
A
--
R
T
L
F
G
D
H
---
E
R
F
E
Q
T
Y
------
F
---
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
--
P
--
S
P
E
L
Y
A
E
V
R
N
W
-------
V
A
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
8
PsiBlast_PDB
66.07
31%
0
- C1 -
-
3EQ6
2
ACS2A_HUMAN
A:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
N
IR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------
26
PsiBlast_CBE
66.04
31%
0
- C1 -
-
2VZE
1
ACS2A_HUMAN
B:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
N
IR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------
22
PsiBlast_CBE
65.98
31%
2
- C1 -
-
2WD9
1
ACS2A_HUMAN
B:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
N
IR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------
3
PsiBlast_PDB
65.88
31%
1
- C1 -
-
2WD9
1
ACS2A_HUMAN
A:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
N
IR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------
5
PsiBlast_PDB
65.53
31%
3
- C1 -
-
3C5E
4
ACS2A_HUMAN
A:
[61-560]
---------------------------------------------------
A
L
W
W
V
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
--
G
D
E
-------------------
V
I
--
Q
E
V
D
T
V
------
A
---------------
S
E
C
P
-----
S
L
R
I
K
L
-
L
V
----
S
E
K
S
C
D
---------
G
W
L
N
-
F
-
K
-
K
-
L
----
L
N
--
E
A
S
T
--------
T
H
H
C
V
E
TGSQ
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
----
E
H
S
Y
S
S
--
L
G
L
K
A
K
M
D
-
A
G
W
T
-------
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
-
F
V
H
-
L
L
P
K
---
F
---
D
P
L
---
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
--
Q
Q
D
-
L
-
S
S
Y
K
F
P
H
----
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
K
---
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
--
K
G
-
N
V
L
P
P
G
T
E
-
G
D
I
G
I
R
V
--
K
P
I
R
-
P
I
---
G
I
--
F
S
G
Y
V
D
N
---
P
D
--
K
T
A
------
A
N
IR
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
--
S
HD
P
E
Q
L
T
K
E
L
Q
Q
H
-------
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
---------