@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM48: (2017-11-06 )
MAEVEQQPTSAPSSPKKRRILRSFLLTILIILLLLVASIIIMMSTDRGSRFLLDRVLQAQQVIKYEYEGGNLLRGIILKNIIAQLKEVDVTLDRADVRLGWRSLILEKEVHLSNADIRNLVIINKAPPSDKPFEFKPIKLPFVLRVDVGDVDHLEIKNSGSVVNFHDVHLNDALWSETKLKFENSSMDMGYLSVHNATGNMDFSGKYPLNATADLRIPSLKSLNIQNIKVAAWGSLDTLQAGVATTTPDLLTGWVVLHPVRHEVPMQGALLLKNYHLPLLVEQKLFAKNGVIKFQGDIKQLNLALETDLKGENLPEGQYNALMNTDLVHQLNITDFNGQVMKGAVNLKGLVNWKDHVTWDIKGRLDHVNPKDKAIPQVVQDFLPPSLDAAVSSTGSLEKGTEVFANVDFDRYESWKLKLNQAPEKNKKPQPMFMNVAWANIDRAMPYIGWLSSGSGQVDLTLRDGQQDIKVSTKVYQHEQTLLPAGQYLATLNVKDNILNVPSFSFAAQKGSLTGQAKALLPSEKRQLAWNALLNAKDFNPQSIHTAAPVNLLNGSIKASGFAKPSQQIIQLEKIDLKGRLAQAGQEMVALAGKSTAALLFNDVKAGGGFKGFAVNYDGSLKALNQANGLLKFSIAGTPEFIRISQLQHDGVAGKIYATGALNLKDRIAWDINSSLVRFKPQYFASSVKGEISGNVKTQGIWSDKLKRIDIQQLNLAGYLNNKPVRGKGNLSILMDSNQKGFLPQQFEANNLFLVYAQNQLQATGNAQNLKIKLNAPALYELYPGLSGRAYGDLSVQSQPRLKATANIAVDNFAFNTLVSIKKLRIQGELPTSETTPTQLTAKLDNLRSGSRQIQSAEVNLTGTRKAHLLKVQGNNNVSKFYVQLAGGFNAKNDWLGQIQKGSFDSRRIRLAQNQNAPVVFSSARSELYVGQHCWQSTNSQLCLDQPVRVSKAQGNISFVTQNLDLGDFAAFMPEGLAMTGQLNGYAKASWVNGGHPKLDARLVTRKGELGLAAEDPQDPPTTLAYDELSVIAKSISEGLLFRVDVKTPDIGTGYANVIINPYQSSMPMHGEVAFNDVQLKVLKPFIQDVRSMSGTLALAGKVNGTLTQPQFTGEMRLKNGAISMISLPVNLTNVQVYSSIRQDMATIDGAFNSGQGVGLLKGSFDWKNAPRLQLNLKGDNLLVRQAPLITAIANPNLTLDMYPFDKRLSLKGSVDVPRARISMPETTAPVVNTSSDVRIVRQGQDPLAILRAAKPWDIRADISVNIGNQVIFQGFNSNIPLVGRLNLTQRGYETAMRAMGAIGVSQKVKIEAYGQSLDLNRAIARFNGPLANPTLDIDANKNVQGSMVGVRVTGTASSPNIQVYNDAGLSEQEALNALVTGRINEGASGLSNAEGFKSDVNNTIAAAGISMGLGGTRALTNQIGRTFGLSGLALDAQGTGDDTQVSLTGYITPDLFIRYGVGVFTPVNKLTLRYQMNRRLYLEASQSLERAIDLFYNWRF
Atome Classification :
(20 SA)
.........10----.........20........30........40........50........60........70........80........90........100.......110......----.120.......130.......140.......150.......160-.........170.......180.......190........200........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430......--.440.......450.......460.......470.......480.......490...----....500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630-------------------...-....---640.....-..650.......660...-....670.......680.......690.......700--.----..-....--.710...------..--..720....--...730.......740..--.....750.....---..760.......770.......780........790.......800.......810-.........820.......830.......840..--.....850.......860.......870......-.880-....--.....890.......900....------------------...910.......920.......-930----.......940.......950.......960..---.....970......--------------------..980.......990.......1000......1010......1020......1030--.........1040-.......1050......1060......1070....---..1080.--....------.-1090.-.....1100......1110.....-....1120........--1130-......----1140......1150--.......1160......1170.......1180--........1190.......1200......1210......1220......1230......1240.....---.1250......-1260......1270-----...---.....1280....----------..1290......1300.......1310.---------.....1320......-1330......1340......1350......1360------...-..------------.1370.....--------.1380..-....1390......1400......1410......1420..----....1430....-..1440......--1450......1460.......1470..-----....1480......1490......1500
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAEVEQQPTS-----APS
S
P
K
K
R
R
I
L
R
S
F
L
L
T
I
L
I
I
L
L
L
L
V
A
S
I
I
I
M
MSTDRG
S
R
F
L
L
D
R
V
L
Q
A
Q
Q
V
I
K
Y
EYEGG
N
L
L
R
G
I
I
L
K
N
I
I
A
Q
L
K
E
V
D
V
T
LDR
A
D
V
R
L
G
W
R
S
L
I
L
E
KEVHLSNADI
R
----
N
L
V
I
I
NKAPPSDKPFEFKP
I
K
L
P
F
V
L
R
V
DVGD
V
D
H
L
E
IKNSG---
S
V
V
N
F
H
D
V
HLNDALWSE
T
K
L
K
FENSSM
D
M
G
-
Y
L
S
V
HNATGN-MDFSGKYPLNATA
D
L
RIPSLKSLNI
Q
N
I
K
V
A
A
WGS
L
D
T
L
QAGVATT
T
P
D
L
L
T
G
W
V
V
L
HP
V
R
HEVPMQ
G
A
L
L
L
KNYHL
P
L
L
V
E
Q
K
L
FAKN
G
V
I
K
FQGD
I
K
Q
L
N
L
A
L
ETDLKGENLPE
G
Q
Y
N
ALMNT
D
L
V
H
Q
L
N
ITDFNG
Q
V
M
KGAVNL
K
G
LVNWKD
H
V
T
W
DIKGRLDHVNP
K
D
K
A
I
P
Q
V
V
Q
D
FLPP
S
L
D
A
A
VSSTGSLEKG
T
E
V
F
A
NVDFDRY
E
S
W
K
L
KLNQAPEKNKKPQ
P
M
F
M
N
V
A
W
--
A
N
I
D
RAM
P
Y
I
G
W
LSSGS
G
Q
V
D
L
T
LRDGQQ
D
I
K
V
S
T
K
V
Y
QHEQTLLPAG
Q
Y
L
A
T
L
NVK----DNILNVPSFSFAAQKGSLTGQ
A
K
ALL
P
S
E
K
R
Q
L
A
W
N
A
LLNAKDFNPQSIHTAAP
V
N
LLNGSIKASGFAKP
S
Q
Q
I
I
Q
L
E
KIDLK
G
R
L
A
Q
A
G
Q
E
M
V
A
LAGK
S
T
A
A
L
L
F
N
DVKAGGGFK
G
F
A
V
NYDGSL
K
A
L
N
QAN
G
L
L
K
-------------------
F
SI-AGTP---
E
F
I
R
I
S
Q
L-QHDGVA
G
K
I
Y
A
TGALNLK-
D
R
I
A
WDINS
S
L
V
RF
K
P
Q
Y
F
A
S
SVKGEISGN
V
K
TQGI---
W
----
S
D
-
K
L
K
R
--
I
D
I
Q
Q
L
N
------
L
A
--
G
YLNNKPVR--GKG
N
L
S
I
L
M
DSNQKGFLP--QQFEAN
N
L
F
L
V
Y
A---QNQLQATGNA
Q
N
L
K
I
K
LNAP
A
L
Y
-
E
LYPGLSGRAYGDLSVQSQPRL
K
A
T
A
N
I
A
V---DN
F
A
F
N
T
L
V
S
I
K
K
L
R
I
Q
GELPTSETT
P
T
Q
L
T
A
K
L
--
D
N
LRSGSR
Q
I
Q
S
A
E
V
N
L
TGTR
K
A
H
L
L
K
V
QGNNN
V
-
S
K
---
F
Y
V
Q
--
L
AGGFNA
K
N
D
W
L
G
QIQKGSFDS------------------
R
R
I
R
L
AQNQNA
P
V
V
F
SSARSEL
Y
-
V
G
Q
----
H
C
W
QSTNS
Q
L
CLDQPV
R
V
SKAQG
N
I
S
F
V
TQNL---D
L
G
D
F
A
-
A
F
MPEG
L
--------------------
A
MTGQLNG
Y
A
K
ASWVNGGHPKL
D
A
R
L
V
TRKGELGLAAEDPQDPPTT
L
A
Y
D
E
L
S
-----
V
I
A
K
S
ISEG
L
L
F
--
R
V
DVKTPDIGT
G
Y
A
N
V
I
INPYQSSMPMHG
E
V
A
FN
D
---
V
Q
L
K
V
L
K
--
P
F
I
Q
------
D
-
V
R
SMS-G
T
L
A
L
A
GKVNG
T
L
TQP---QFT
G
E
-
M
R
LKNG--
A
I
S
M
I
S
LP--
V
N
L
T
-
N
V
Q
V
Y
S
----
S
I
R
Q
D
M
A
T
IDGAF---NSGQ
G
V
G
L
LKGSFDWKNA
P
-
R
L
Q
L
N
LKGD
N
----
L
L
V
RQA
P
L
I
T
A
-IANP
N
L
T
L
D
MYPFDKRLSLKGSVDVPRARISMPETTA
P
V
VNTSS
D
V
R
I
V
RQGQD
P
L
---
A
I
LRAAKPW
D
I
-
R
A
D
I
S
V
NIG
N
Q
V
-------
I
F
Q---GFNSNI
P
L
V
G
RLN----------L
T
Q
R
G
Y
E
T
A
M
R
A
M
-
G
AIGV
S
Q
K
V
K
I
E
A
Y---------GQSL
D
L
N
R
A
I
A
RFNG-PLAN
P
T
L
D
IDANKNVQG
S
M
V
G
V
R
V
TGTASSP
N
I
Q
------
V
Y
N-DA------------GL
S
E
Q
E
A
L
N
A
--------
L
V
TGRIN-EGASGLSNAEGFKSDVN
N
T
I
A
A
A
GISMGLG
G
T
R
A
L
T
N
Q
I
G
----
R
T
FGLS
G
L
A
L
DA-QGTGDD
T
Q
V
S
L
T
--
G
YI
T
P
D
L
F
I
R
YGV-GVFTPV
N
K
L
T
L
R
Y
-----QMN
R
R
L
Y
L
E
A
S
Q
S
L
E
R
A
I
D
L
F
YNWRF
30
Fugue
65.85
18%
18
* C9 *
-
4W8J
-
CR1AC_BACTK
A:
[33-1178]
-------
Y
T
P
-----
I
D
I
S
L
S
L
T
Q
F
L
L
S
E
F
V
P
G
A
G
F
V
L
G
L
V
D
I
I
W
G
I
F
G
P
S
Q
W
D
A
F
L
V
----
Q
I
E
Q
L
I
N
Q
R
I
E
----------------------
E
F
A
R
N
Q
A
I
S
R
L
E
G
L
S
N
L
Y
Q
I
Y
A
E
S
F
R
E
W
----
E
A
D
P
T
N
P
A
L
R
E
E
M
R
I
Q
F
N
D
M
N
S
A
L
T
T
A
I
P
L
L
A
V
Q
N
Y
Q
V
P
L
L
S
V
Y
V
Q
A
A
N
L
H
L
S
V
L
R
D
V
S
V
F
G
Q
R
W
G
F
D
A
A
T
I
N
S
R
-
Y
N
D
L
T
R
L
I
G
N
Y
T
D
Y
A
V
R
W
Y
N
T
G
L
E
R
V
W
G
P
D
----------
S
R
D
W
V
R
Y
N
Q
F
R
R
E
L
T
L
T
V
L
D
I
V
A
L
F
P
N
Y
D
S
R
R
Y
P
I
R
T
V
S
Q
L
T
R
E
I
Y
T
N
P
V
L
E
-----------
N
F
D
G
S
F
R
G
S
A
Q
G
I
E
R
S
I
R
S
P
H
L
M
D
I
L
N
S
I
T
I
Y
T
D
A
H
R
--
G
Y
Y
Y
W
S
G
H
Q
I
M
A
S
P
----
V
G
F
S
G
P
E
F
T
F
P
L
Y
G
T
M
G
N
A
A
P
Q
Q
R
I
V
A
Q
-----
L
G
Q
G
V
Y
R
T
L
S
S
T
L
Y
R
R
P
F
N
Q
Q
L
S
V
L
D
-------
G
T
E
F
A
Y
G
T
S
S
N
--------------------
L
P
S
A
V
Y
R
K
S
G
T
-------
V
D
S
L
D
E
I
P
P
Q
N
N
N
V
P
P
R
Q
G
F
---
S
H
R
L
S
H
V
S
M
F
R
S
G
F
V
S
I
I
R
A
P
M
F
S
W
I
H
R
------------------------------------
S
A
E
V
N
N
I
I
-----------
A
S
D
S
I
T
Q
I
P
--
A
V
K
G
N
F
L
F
N
G
-----------------
S
V
I
S
G
P
G
F
T
G
------
G
D
L
V
R
L
N
S
S
N
---------------------------
I
Q
N
R
---
G
Y
I
E
V
P
------------------------
I
H
F
P
S
T
S
T
R
Y
R
V
R
V
R
Y
A
-
S
V
T
P
I
H
L
N
V
N
W
G
N
S
S
I
---
F
----
S
N
-
T
V
P
A
TA
T
S
L
D
N
L
Q
------
S
S
D
F
G
Y
F
E
S
A
N
A
F
--
T
G
N
I
V
G
V
R
N
F
S
G
T
A
G
V
I
I
--
D
R
F
E
F
I
P
V
--------
T
A
T
L
E
A
E
Y
N
L
E
R
A
Q
K
A
V
N
A
------
L
F
T
--
S
T
N
Q
L
G
L
K
T
N
V
T
D
Y
H
I
D
Q
V
S
N
L
V
T
---
Y
------
L
S
D
E
F
S
L
D
E
K
R
E
L
S
E
K
V
K
H
A
K
R
L
S
D
E
R
--
N
L
L
Q
D
S
N
F
K
D
I
N
R
E
R
G
W
G
G
S
T
G
---
I
T
I
Q
G
G
D
D
V
F
K
E
---
N
Y
V
T
--
L
S
G
T
F
D
--------------
E
S
------------------
Y
P
T
Y
L
Y
Q
K
I
D
E
S
K
L
K
A
F
T
R
Y
Q
L
R
---------------------------------
G
Y
I
E
D
S
Q
---
D
L
E
I
Y
L
-
I
--------------------------------------------------
R
Y
N
A
K
H
E
T
V
N
V
P
G
T
G
S
S
A
H
H
S
H
H
F
S
L
D
I
D
-----
V
G
S
T
D
L
N
E
D
L
G
V
--
W
V
I
F
K
I
K
T
------------------
Q
D
G
H
A
R
L
G
N
---
L
E
F
L
E
E
K
--
P
L
V
G
---------
E
A
L
A
-
R
V
K
R
A
E
K
K
W
R
D
K
R
E
K
L
---
E
W
E
T
N
-
I
V
Y
K
E
A
--
K
E
S
V
D
A
L
F
--
V
N
-----
S
Q
Y
D
----
Q
L
Q
A
D
T
-
N
I
A
M
I
H
---
A
A
D
K
R
V
H
S
I
R
E
A
Y
L
----
P
-
E
L
S
V
---------------
I
P
G
V
N
A
-
A
I
F
E
E
L
E
G
R
I
F
T
A
F
S
L
Y
D
A
R
--------------------------
N
V
I
K
N
G
D
-------
F
N
N
G
L
S
S
W
N
V
-
K
G
H
V
D
V
E
E
Q
N
N
-----------------------
Q
R
S
V
----------
L
V
V
P
E
W
E
A
E
---------
V
S
Q
E
V
R
V
S
P
------------------------------------------
G
R
G
Y
I
L
R
V
T
A
Y
K
E
G
-----------
Y
G
-
E
G
------------
S
V
T
I
H
E
I
E
N
N
--------
T
D
E
L
K
F
S
-
N
P
------------------------------------------------------------------
V
--
G
Y
V
T
K
E
L
E
Y
-------
F
P
E
T
D
K
V
W
I
E
I
-----
G
E
T
E
G
T
F
I
V
D
S
V
E
L
L
L
M
E
E
-------
31
Fugue
51.81
19%
13
* C11 *
-
5H41
3
?
A:
[2-1114]
---
G
I
L
K
T
L
S
-----
A
P
------------------
I
I
L
E
N
S
N
S
T
F
T
F
L
P
G
G
D
N
F
E
W
I
H
E
S
I
M
----
I
N
A
F
Q
---
G
N
T
L
D
G
S
T
-
N
N
L
Y
L
R
I
Y
K
--------
D
N
S
L
A
F
Y
P
L
I
G
M
N
----
S
K
S
T
I
K
S
G
TS
T
L
I
F
E
G
T
A
E
D
---------
I
S
Y
T
V
T
F
R
L
T
P
Y
G
I
W
F
W
D
I
S
L
S
G
---
N
C
N
K
A
D
I
I
Y
S
Q
D
-
I
G
V
G
T
K
G
S
V
N
S
N
E
L
Y
L
A
Q
Y
L
G
H
S
I
F
Q
G
D
---------------------
Y
G
Y
V
I
C
S
R
Q
N
M
A
Q
G
D
L
---------------------
F
P
----
Y
L
Q
Q
G
S
L
G
I
R
-----------------
S
I
A
Y
S
T
D
G
T
Q
F
---
F
G
L
S
Y
K
K
T
N
I
P
E
A
L
Y
G
D
L
P
S
K
N
K
Q
Y
E
L
----
A
H
T
A
L
Q
T
E
A
F
S
L
S
G
----
T
K
Q
F
S
F
Y
G
I
C
K
T
N
H
--------
P
E
V
I
R
E
---------
I
E
Y
I
Q
E
L
E
K
A
Y
A
--------
Y
H
E
S
G
E
I
L
P
V
N
V
P
T
L
Q
N
I
G
A
P
-
Y
A
S
S
R
W
D
A
K
Q
V
E
H
Y
F
P
----------
K
R
L
L
E
E
K
E
E
E
A
L
L
S
F
F
T
P
--------------------------------------
E
K
S
H
V
V
L
Q
D
K
E
L
---
T
T
E
R
P
H
G
H
I
L
M
T
N
F
D
V
T
K
V
P
Q
G
V
V
S
S
T
N
Y
M
Y
G
A
F
N
C
Q
----------------------------------------------------
F
V
V
G
N
T
T
Y
N
K
L
L
S
N
H
R
G
L
L
N
-------------------
I
Q
K
D
S
G
Q
R
---
I
F
I
K
I
----------
G
D
C
Y
R
Q
L
T
L
P
-----
A
A
Y
E
M
N
V
A
---------
G
S
T
W
Y
Y
Q
L
D
E
D
V
L
I
I
T
S
---
F
----
A
---------------------------
M
Y
N
R
P
---------
E
I
V
L
K
V
Q
S
L
G
H
K
K
--
Y
D
F
I
V
T
H
Q
L
T
V
G
P
NEY
E
N
E
I
K
L
T
R
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G
N
I
L
Q
L
S
P
T
D
P
V
V
T
N
H
F
Y
P
E
L
S
F
R
M
R
----------
I
P
E
D
C
T
L
S
D
---
D
S
I
F
F
H
N
N
T
T
I
--------------
N
P
S
L
L
S
I
E
I
--
L
Q
K
S
S
F
D
I
V
M
Q
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F
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T
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N
V
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F
L
D
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Y
K
E
Q
L
E
A
Y
-
R
I
---
Y
Y
D
Q
--
L
V
C
N
F
K
L
S
A
P
--
D
K
I
P
L
S
A
E
K
L
------------------
N
A
I
I
H
W
Y
A
H
D
A
L
I
H
F
A
S
P
H
G
L
E
Q
-
S
G
G
----
A
A
W
G
T
R
D
V
------------
C
Q
G
P
I
E
F
F
L
T
T
G
---
H
F
D
L
V
R
-
H
I
L
I
T
L
Y
--------------------
S
H
Q
I
E
-
G
G
F
E
W
P
Q
W
F
M
F
D
H
-------------
Y
P
I
H
Q
E
D
C
H
G
D
V
V
F
W
P
L
K
A
I
S
-----
D
Y
I
Q
A
T
G
D
T
S
I
L
N
E
L
V
D
Y
R
T
A
K
------
D
A
L
P
T
N
Q
P
E
T
I
L
I
H
I
K
R
A
V
T
T
---
I
K
N
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Y
L
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GT
A
L
I
S
YAGGDW
D
-
D
T
L
Q
P
-
A
N
S
E
L
K
E
N
L
V
S
A
W
T
Q
A
---
L
A
E
Q
T
-
L
E
L
L
C
S
--
A
I
K
G
I
D
H
D
--
F
S
K
E
-
L
S
H
M
A
N
----
D
I
R
T
S
F
Y
Q
Y
---
L
---
I
K
D
---
G
V
I
A
G
F
L
Y
R
E
S
E
E
-
H
M
K
Y
M
L
H
P
D
D
TESS
I
H
Y
R
L
L
P
L
T
R
S
-
I
I
-------
A
Q
L
A
D
F
K
L
A
T
R
-
N
L
E
I
I
D
E
H
L
A
C
P
D
----------
G
V
R
L
M
---
D
H
P
A
---
S
Y
S
G
G
I
S
K
I
F
L
-
R
A
E
Q
A
A
N
V
G
R
E
I
-------
S
L
Q
Y
V
H
A
H
I
R
Y
I
E
A
L
A
T
M
G
----------
L
S
K
K
A
W
D
A
L
M
R
I
--------------------------------------------
N
P
I
L
L
T
D
Y
V
P
N
A
L
T
R
Q
S
N
V
Y
F
S
S
S
E
G
C
F
-------------
D
D
------------
R
Y
E
Y
A
K
N
F
D
K
--------
L
R
T
G
D
I
N
V
K
G
G
W
R
L
Y
S
S
-------
G
P
G
I
Y
I
R
R
I
I
A
D
L
L
G
I
R
F
G
H
N
V
I
H
I
D
P
V
V
T
K
E
L
D
G
V
T
L
Q
F
-
T
C
F
G
K
T
V
F
F
T
Y
H
V
D
D
T
M
D
K
H
I
C
V
K
S
N
--
N
N
I
L
P
G
D
N
L
N
N
I
Y
R
D
G
G
I
Q
I
A
K
D
V
F
L
S
A
A
M
S
-
D
N
N
F
H
I
Y
V
K
N
--
35
Fugue
45.50
21%
27
* C10 *
-
3W5F
6
?
A:
[3-708]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
E
F
S
V
S
Y
D
D
--
R
A
I
I
I
-
N
G
K
R
K
-------------------
I
L
I
-
S
G
S
I
---
H
Y
P
R
S
T
P
Q
-
M
W
P
D
L
I
Q
K
A
K
D
G
G
-
L
D
V
I
-
E
T
Y
V
F
W
N
G
H
E
P
S
P
G
K
Y
N
F
E
G
R
Y
D
L
V
R
F
I
K
M
V
Q
R
A
G
L
---
Y
----
V
N
L
R
I
G
P
--
Y
V
C
A
E
W
N
------
F
G
--
G
F
----
P
V
W
--
L
K
Y
V
P
G
M
E
F
R
T
N
N
Q
P
F
K
V
A
M
Q
G
F
V
Q
K
I
V
N
M
M
K
S
---
E
N
L
F
E
S
Q
G
G
P
I
I
M
A
Q
I
E
N
E
Y
G
P
V
-
E
W
E
I
G
A
P
G
K
A
Y
T
K
W
A
A
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M
A
V
G
L
K
T
G
V
P
W
I
M
C
KQ
E
D
A
P
D
P
V
I
D
T
C
N
G
F
Y
C
E
G
F
R
P
N
K
P
Y
K
P
K
M
W
T
E
V
W
T
G
W
Y
T
K
F
G
G
P
I
P
Q
R
P
---
A
E
D
I
A
F
S
V
A
R
F
V
Q
N
N
G
S
F
-
F
N
---
Y
Y
M
Y
--
H
-
G
G
T
N
F
G
R
T
S
S
G
L
F
I
A
T
S
Y
D
Y
DAPLDEYGLLNE
P
K
Y
G
H
L
R
D
L
H
K
A
I
K
L
S
E
P
A
L
V
S
S
Y
A
A
V
T
S
-
L
G
S
N
Q
E
A
H
V
Y
R
S
K
S
G
A
C
A
A
F
L
S
N
Y
D
S
R
Y
S
V
K
V
T
F
Q
N
R
P
Y
---
N
L
P
P
W
S
I
S
I
L
P
D
----------------------
C
K
T
A
V
Y
N
T
----
A
Q
V
N
S
Q
S
S
S
I
K
M
T
P
A
G
G
G
L
S
W
Q
S
Y
N
E
E
T
P
T
A
L
T
A
N
G
L
W
E
Q
K
-----
N
V
T
R
D
S
S
D
Y
L
W
Y
--
M
T
N
V
N
I
A
S
-
N
E
G
F
L
K
N
G
K
D
P
Y
L
T
V
M
S
-------------
A
G
H
V
L
H
--
V
F
V
N
------
G
-
K
L
S
---------
G
T
V
Y
G
T
L
D
N
P
K
L
-
T
Y
S
G
N
-
V
K
L
R
A
G
I
N
K
I
S
L
L
S
V
S
--
V
G
L
P
-
N
V
G
V
H
------
Y
D
T
W
N
A
G
V
L
G
P
V
---
T
L
S
---
G
L
N
E
G
S
R
N
L
A
K
Q
K
W
S
Y
K
V
G
L
K
G
E
S
----
L
S
L
H
-------------------------
S
L
S
G
S
S
S
V
E
W
V
R
G
S
L
M
A
Q
K
Q
P
L
T
W
Y
K
A
T
F
N
-
A
P
G
G
N
D
P
L
---
A
L
D
M
A
S
M
G
----
K
G
Q
I
W
I
N
-
G
E
G
V
GRHWPGY
I
A
Q
---
G
D
C
S
K
C
S
Y
A
G
T
F
N
EKKCQTNCGQ
P
S
Q
R
W
Y
H
V
P
R
S
W
L
-
K
P
S
G
-
N
L
L
V
V
F
E
E
W
---------
G
G
N
P
T
G
I
S
L
V
R
R
S
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
41.10
18%
30
- C10 -
-
4TXG
-
?
A:
[107-793]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
L
V
Q
V
P
P
P
--
T
G
N
A
L
C
R
P
E
A
L
A
Q
T
Q
G
V
DVP
Y
----
C
A
-
V
Y
K
Q
--
G
G
A
E
Q
L
A
NGSR
R
R
I
I
--
G
Y
F
T
S
W
R
T
G
--
K
D
G
S
P
A
Y
L
A
S
D
I
P
W
S
K
L
T
----------
H
I
N
Y
A
---
F
A
H
V
D
G
S
N
K
L
S
V
N
E
T
A
P
G
N
P
A
T
D
-
M
S
W
P
G
V
A
G
-
A
E
M
D
A
S
L
P
Y
K
G
H
F
N
L
L
T
Q
Y
K
R
---
K
Y
P
G
V
K
T
L
I
S
V
G
G
W
A
E
T
G
G
Y
F
D
A
N
G
K
R
V
A
S
G
G
F
Y
--
S
M
T
V
N
A
D
G
T
V
N
Q
A
G
I
N
A
F
S
D
S
A
V
A
F
L
R
K
Y
G
F
D
G
V
-
D
I
DFE
Y
P
T
S
--
M
N
N
A
G
N
P
L
D
W
T
F
S
N
A
R
L
G
S
L
N
K
------------------
G
Y
V
A
L
L
Q
T
L
R
D
R
L
D
R
A
A
A
Q
D
G
R
Y
-
Y
--------------
Q
I
T
A
A
V
P
A
S
G
Y
L
L
R
G
M
E
T
F
--
Q
G
L
---
K
Y
L
D
F
V
-
N
V
M
S
Y
D
L
HGAWNR
F
V
G
P
NAALYDDGKD
A
E
L
A
F
W
N
V
Y
S
T
P
Q
Y
G
N
I
G
Y
L
N
T
D
W
A
Y
H
Y
Y
R
G
G
L
P
A
S
R
V
N
M
G
V
P
Y
Y
T
R
G
W
K
N
V
S
GGSNG
L
W
G
S
S
V
G
S
N
------
C
P
A
G
L
T
E
C
G
D
G
A
V
G
-
I
D
N
I
W
H
D
L
D
D
S
G
K
E
I
P
G
G
S
---
N
P
M
W
H
A
K
--
N
L
E
K
------
G
----
L
A
-
G
S
Y
L
A
A
Y
G
I
D
P
T
L
P
I
N
---
Q
L
T
G
S
Y
Q
R
N
Y
N
G
--
A
L
A
A
P
W
L
W
--
N
A
G
K
-
K
V
F
L
S
T
E
D
E
Q
S
I
A
Q
K
A
A
W
I
D
A
N
N
---
V
G
G
V
M
F
W
E
L
A
G
D
Y
D
W
K
A
Q
R
-
N
---
N
G
Q
G
E
Y
----
F
I
---
G
T
T
L
T
S
-
L
L
Y
N
T
F
S
Q
P
P
K
V
S
A
P
T
A
A
I
D
V
G
F
S
L
G
G
--
F
K
L
G
D
Q
N
Y
P
I
---
N
P
K
L
T
I
V
N
R
S
Q
T
T
L
P
GG
T
E
F
Q
F
D
V
P
T
S
A
-
P
A
N
I
A
D
Q
S
G
F
G
L
-------
K
V
V
---
S
A
G
H
S
G
S
N
V
G
G
L
K
----------
G
D
F
N
R
V
S
V
K
L
P
S
W
-
Q
S
L
G
A
G
Q
S
V
T
L
D
V
V
Y
Y
L
PISGPS
H
Y
T
V
G
L
N
G
K
T
Y
A
I
R
D
E
A
P
Y
L
P
Y
L
R
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
36.81
18%
14
- C5 -
-
5C37
2
FAS_HUMAN
A:
[1-655]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
Q
Q
V
P
I
L
E
K
F
C
F
T
P
---
H
T
E
E
G
C
L
S
E
R
A
A
L
Q
E
E
L
Q
L
C
K
G
L
-
V
Q
A
L
Q
T
K
A
Q
I
P
R
D
P
S
Q
Q
E
L
P
R
L
L
S
A
A
C
R
L
Q
---
L
N
G
N
L
Q
L
E
L
A
Q
V
L
A
Q
E
R
P
K
L
P
E
--------------
D
P
L
L
S
G
L
L
D
--------
S
P
A
L
K
A
C
L
D
T
A
V
E
N
M
P
S
-
L
K
---
M
K
V
V
E
V
L
A
G
H
G
H
L
Y
S
R
I
P
G
L
L
S
P
H
P
L
L
Q
------------------
L
S
Y
T
A
T
D
R
H
P
Q
A
L
E
A
A
Q
A
E
L
Q
Q
H
D
V
A
Q
----
G
Q
W
D
P
A
D
P
A
---------
P
S
A
L
G
S
A
D
L
L
V
C
N
C
AVA
A
L
G
D
P
A
-
S
A
L
S
N
M
V
--------------------
A
A
L
R
E
-
G
G
F
L
L
L
H
T
L
L
R
G
H
P
L
G
D
I
V
A
F
L
T
S
G
Q
-
G
I
L
S
Q
D
A
W
E
S
L
F
S
R
V
S
L
R
L
V
-----
G
L
K
K
S
F
Y
G
S
T
L
F
--
L
C
R
R
P
T
P
Q
D
S
P
I
F
L
P
V
D
D
T
S
F
R
W
V
E
S
L
K
G
I
L
A
D
E
D
---
S
S
----
R
--
P
V
W
L
------
K
-
A
I
N
C
A
--
T
S
G
V
V
G
L
V
N
C
L
R
R
E
P
------
G
G
-
N
R
L
R
C
V
--
L
L
S
--------
N
L
S
-
S
T
S
H
V
P
----
E
V
D
P
G
S
A
E
L
Q
K
V
L
---
Q
G
D
L
V
M
N
V
Y
R
D
G
-
A
W
G
A
F
R
-
H
F
L
L
E
E
D
S
K
T
----
G
C
P
A
H
K
S
Y
I
I
A
-
G
G
L
G
G
F
G
L
E
L
A
Q
W
L
I
Q
----------------
R
G
V
Q
K
L
V
L
T
S
R
S
G
I
R
T
G
Y
Q
A
K
Q
V
R
---
R
W
R
R
Q
G
V
Q
V
Q
V
S
T
S
N
I
S
S
L
E
G
A
R
G
-------
L
I
A
---
E
A
A
Q
L
G
P
V
G
G
V
F
N
----------
L
A
V
V
L
R
D
G
L
L
E
N
Q
-
T
P
E
F
F
Q
D
V
C
K
P
-
K
Y
---------
S
G
T
L
N
L
D
R
V
T
R
E
A
C
------
P
E
L
D
-----------
Y
F
V
V
F
S
S
V
S
C
G
R
G
N
A
------
G
Q
S
-
N
Y
------------
G
F
A
N
S
-
A
M
E
R
--------
I
C
E
K
R
R
H
-
E
G
L
P
G
L
A
V
Q
W
G
A
I
G
D
V
-------
G
I
L
V
E
T
M
S
T
N
D
T
I
V
S
G
T
----
L
P
Q
R
M
A
S
C
L
E
V
L
-
D
L
F
L
N
Q
P
H
M
V
L
S
--
S
F
V
L
A
E
----------------------------------------------------
36
Fugue
34.86
18%
25
- C9 -
-
4DN7
3
?
A:
[24-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
E
Q
V
S
L
K
K
R
A
E
S
A
A
E
K
K
A
A
F
G
E
D
F
E
L
-----
E
K
Y
E
E
G
S
K
V
S
K
P
--
I
E
D
L
Q
S
L
D
E
E
S
K
K
T
L
L
Q
V
G
V
I
P
S
E
E
G
R
S
G
S
F
L
V
L
D
NAV
S
H
S
T
L
K
D
--
K
N
V
E
------
L
M
S
T
H
K
A
M
E
K
Y
E
W
L
K
D
Y
S
W
K
L
V
Q
V
DAD
K
Y
T
A
K
-
T
Y
L
E
D
A
--
D
G
Y
F
I
R
V
P
A
G
K
K
T
S
M
P
V
Q
T
C
L
M
---
L
G
S
K
K
A
A
Q
T
V
H
N
I
I
I
V
E
E
G
A
T
L
D
I
I
T
G
C
T
T
K
K
G
V
E
-
E
-
G
L
H
L
G
I
S
E
M
---
Y
I
K
K
G
G
T
L
N
F
T
M
I
H
N
W
A
E
Q
I
G
V
R
P
R
T
V
V
S
V
E
E
G
G
T
Y
V
S
N
Y
I
C
L
K
P
---
V
R
S
V
Q
T
Y
P
T
V
R
L
E
G
E
G
-------
A
V
T
R
L
N
T
I
A
I
A
-
H
P
G
S
E
L
D
L
G
S
K
A
-------
I
F
N
---
A
P
G
T
R
A
E
L
I
S
R
T
I
----------
T
--
I
G
G
R
L
I
A
R
G
E
M
I
G
N
A
K
G
A
K
G
H
L
E
C
K
---------
G
L
V
L
T
------
D
K
G
S
-
Q
L
A
I
P
I
L
E
----
A
N
V
D
D
I
E
L
T
H
E
A
A
V
G
K
I
A
K
D
Q
V
------
E
Y
L
M
A
R
------------
G
L
T
E
D
E
A
V
G
M
--------
I
I
R
G
F
L
D
-
V
G
I
R
G
I
P
--
E
E
L
K
E
E
I
E
N
T
I
A
Q
T
A
L
G
-------------------------------------------------------------------------------------------------------
33
Fugue
30.57
21%
27
- C4 -
-
5CMN
-
AGRL3_HUMAN
E:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
SDHQSGAWCKDPLQASDKI
Y
Y
M
-
P
W
T
P
YRT
D
T
L
T
E
Y
S
S
-
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
---------------------
G
E
A
I
I
A
------
N
A
--
N
Y
H
D
T
S
P
Y
R
WG
G
K
S
D
I
D
L
A
V
D
E
N
--------------
G
L
W
V
I
Y
A
---
T
E
Q
N
N
------------
G
K
I
V
I
S
-
Q
L
N
P
-
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
-
S
A
S
N
A
F
M
I
-------
C
G
I
L
Y
V
V
K
S
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
--
P
N
---
S
Y
Q
Y
I
A
A
V
D
Y
N
----
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
-
V
K
---
Y
S
L
D
--
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
30.49
24%
-139
* C8 *
-
4XTR
-
?
G:
[15-26]
-----------------------
R
W
R
V
Y
L
L
I
V
L
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
27.69
16%
-216
- C11 -
-
1PG1
1
?
?:
[1-18]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
G
G
R
----
L
C
Y
C
R
R
R
F
C
V
C
V
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
22.75
33%
138
- C1 -
-
1YFN
-
RSEA_ECOLI
G:
[1-15]
----
E
A
Q
P
A
P
HQWQK
M
P
F
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
21.32
42%
-
- C3 -
-
2JPW
-
TNNI3_MOUSE
A:
[11-22]
----
E
P
Q
P
A
P
-----
A
P
V
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
19.66
29%
10
- C- -
-
1P3C
-
?
A:
[29-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
C
T
G
T
L
I
A
P
N
K
I
L
T
N
GHC
V
Y
N
-
T
A
SRSYSA
K
G
S
V
Y
P
G
M
N
D
S
T
A
V
N
G
S
A
N
M
T
E
F
Y
V
P
S
G
Y
I
N
-
T
G
A
S
Q
Y
D
F
A
V
-
I
K
T
D
T
N
-----
I
G
N
T
V
G
Y
R
S
I
R
Q
V
T
N
L
T
G
----
T
T
I
K
I
S
G
Y
P
G
D
K
M
R
S
T
G
K
V
S
Q
W
E
M
S
--
G
S
V
T
------------------------------------------------------
18
PsiBlast_PDB
19.42
29%
9
- C6 -
-
1P3E
-
?
A:
[29-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
C
T
G
T
L
I
A
P
N
K
I
L
T
N
G
H
C
V
Y
N
-
T
A
SRSYSA
K
G
S
V
Y
P
G
M
N
D
S
T
A
V
N
G
S
A
N
M
T
E
F
Y
V
P
S
G
Y
I
N
-
T
G
A
S
Q
Y
D
F
A
V
-
I
K
T
D
T
N
-----
I
G
N
T
V
G
Y
R
S
I
R
Q
V
T
N
L
T
G
----
T
T
I
K
I
S
G
Y
P
G
D
K
M
R
S
T
G
K
V
S
Q
W
E
M
S
--
G
S
V
T
------------------------------------------------------
10
PsiBlast_PDB
19.05
25%
39
- C8 -
-
1WTH
-
BP27_BPT4
D:
[266-368]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
T
G
K
G
E
N
S
I
V
V
S
R
S
G
A
Y
S
E
M
T
Y
R
N
G
Y
----------------------------
E
---
E
A
I
R
L
Q
T
M
A
Q
Y
D
G
Y
A
-
K
C
S
T
I
G
N
F
N
L
T
-
P
G
V
K
I
I
F
N
D
S
K
N
Q
F
K
T
E
F
Y
V
D
E
V
I
H
E
L
S
N
N
N
S
V
T
H
L
---
Y
MFTN
A
T
-
K
L
E
T
--
I
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
18.61
25%
18
- C8 -
-
2Z6B
-
BP27_BPT4
D:
[266-368]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
T
G
K
G
E
N
S
I
V
V
S
R
S
G
A
Y
S
E
M
T
Y
R
N
G
Y
----------------------------
E
---
E
A
I
R
L
Q
T
M
A
Q
Y
D
G
Y
A
-
K
C
S
T
I
G
N
F
N
L
T
-
P
G
V
K
I
I
F
N
D
S
K
N
Q
F
K
T
E
F
Y
V
D
E
V
I
H
E
L
S
N
N
N
S
V
T
H
L
---
Y
MFTN
A
T
-
K
L
E
T
--
I
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
18.58
11%
85
- C8 -
-
1Q90
1
?
R:
[6-23]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
------------
D
M
N
K
R
N
I
M
N
L
--------
I
L
A
G
G
A
-----------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
17.48
40%
26
- C8 -
-
1Y3Q
-
?
A:
[78-117]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
F
I
R
Y
G
M
E
G
A
F
I
P
L
N
K
L
I
D
Q
N
-----
A
P
N
L
K
A
F
F
K
T
H
P
E
V
Q
R
A
I
--------
7
PsiBlast_PDB
17.48
40%
22
- C8 -
-
3VLV
-
?
A:
[78-118]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
F
I
R
Y
G
M
E
G
A
F
I
P
L
N
K
L
I
D
Q
N
-----
A
P
N
L
K
A
F
F
K
T
H
P
E
V
Q
R
A
I
--------
8
PsiBlast_PDB
17.25
40%
28
- C8 -
-
3VLW
2
?
A:
[78-117]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
F
I
R
Y
G
M
E
G
A
F
I
P
L
N
K
L
I
D
Q
N
-----
A
P
N
L
K
A
F
F
K
T
H
P
E
V
Q
R
A
I
--------
9
PsiBlast_PDB
17.09
25%
-
- C8 -
-
1PDJ
-
BP27_BPT4
D:
[266-368]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
T
G
K
G
E
N
S
I
V
V
S
R
S
G
A
Y
S
E
M
T
Y
R
N
G
Y
----------------------------
E
---
E
A
I
R
L
Q
T
M
A
Q
Y
D
G
Y
A
-
K
C
S
T
I
G
N
F
N
L
T
-
P
G
V
K
I
I
F
N
D
S
K
N
Q
F
K
T
E
F
Y
V
D
E
V
I
H
E
L
S
N
N
N
S
V
T
H
L
---
Y
MFTN
A
T
-
K
L
E
T
--
I
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------