@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM50: (2017-11-06 )
MLEAYRQHVAERAALGVPPKPLDDAQTAQLVELLKNPPAGEEAFLVDLLENRVPAGVDQAAYVKAAFLAAIAKGEATSPLVSKERAVYLLGTMLGGYNVAPLVELLDDAELGSLAAEALKKTLLVFDAFHDVADKAKAGNANAKAVLQSWADAEWFTSRKDVPEEIKITVFKVTGETNTDDLSPAQDAWSRPDIPLHANAMLKNERDGINPEKPGEVGPLSQIKELIAKGNQVAYVGDVVGTGSSRKSATNSVLWFFGDEIAHIPNKKDGGVCLGGKIAPIFFNTMEDAGALPVEIDVSNMNMGDEVTLKIDHAAAKVTAFKNGEQIAESELKTPVLLDEVHAGGRINLIIGRGLTAKAREVLGLAPSTLFRTPVQPADTGKGFTLAQKMVGRACGLPEGQGIRPGTYCEPKMTTVGSQDTTGPMTRDELKDLACLGFSADLVMQSFCHTAAYPKPVDVQMQHTLPDFIMNRGGVSLRPGDGIIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFAAATGVMPLDMPESVLVKFKGKMQPGITLRDLVHAIPYYAIKEGDLTVEKKGKKNIFSGRILEIDLTEMETDLTVEQAFELSDASAERSAAGCAITLSEEKVAEYLRSNITMLKWMISQGYGDARTMARRVENMEKWLANPSLLKADADAEYTKVYEIDLSEIKEPILCCPNDPDDAKLLSDVQGDKIDEVFIGSCMTNIGHFRAAGQLLEKVPSGSLTTRLWLAPPTRMDEHQLMEEGFYNTYGRAGARTEMPGCSLCMGNQARVAPNTTVVSTSTRNFPNRLGQGSNVYLASAELASVAAVLGKLPTPEEYQQYAAQIDSMSADIYKYLNFDQMGEYTNAADKVDTKKIAAAQLT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400..-..-...410.......420.......430..----.-..-..440..------....---------.------450.....---------------..460.......470.....----.-..480.....-.--.490---------.--..-......500...-------....---510-.........--520.......530.......540.......550......---------.560.......570......-.580.......-590.......600.......610......-.620.......630.......640.......650.......660.....----..670.......680.......690.......700....------.---------------------------------------.-.710--------.......720-........730.------.---..-...740.........750.......760.......770.......780.----.-.--...--.790------.--.---.......800.....--.-.--810.......820.......---------830.......840....---------...850.......860.......870.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
E
A
Y
R
Q
H
V
A
E
RAALGVPPKPLD
D
A
Q
T
A
Q
L
V
E
L
LKNPPAG
E
E
A
F
L
V
D
L
L
ENRVPAGV
D
Q
A
A
Y
V
K
A
A
F
L
A
A
I
AKGEATSPLVSKE
R
A
V
Y
L
L
G
T
MLGGY
N
V
A
P
L
V
E
L
LDDA
E
L
G
S
L
A
A
E
A
L
K
K
T
L
L
V
F
D
A
F
H
D
V
A
D
KAKAGNA
N
A
K
A
V
L
Q
S
WAD
A
E
WFTSRKDVPE
E
I
K
I
T
V
F
K
V
TGETNTDDLSP
A
Q
DAWSRPDIPLH
A
N
A
MLKNERDGINPEKPGEVG
P
L
S
Q
I
K
E
L
I
AKGN
Q
V
A
Y
V
G
D
V
VGTGSSRKSATN
S
V
L
W
F
FG
D
E
I
A
HIPNKKDG
G
V
C
LG
G
K
I
A
P
I
F
F
NTMEDAGA
L
P
V
E
I
D
VSNMNMG
D
E
V
T
L
K
I
DHA
A
A
K
V
T
AFKN
G
E
Q
I
A
E
S
ELKT
P
V
L
L
D
EVHAG
G
R
I
N
L
I
IGRGL
T
A
K
A
R
E
V
LGLA
P
S
T
L
FRTPVQPADTGK
G
F
T
L
A
Q
K
M
V
G
RACGLPEGQGIR-PG-TYCEPK
M
T
TVGSQDTTGPM
T
R
D
E
L
K
D
L
A
----C-LG-F
S
A
D
L
V
M
------
Q
S
F
C
---------H------TAAYPKPV---------------
D
V
Q
M
QHT
L
P
D
F
I
M
N-RGGVS----L-RPG
D
G
I
I
H
S
W
-
L
--NR-----------M--LL-PDTVGTGGDSH
T
-------
R
F
P
I
---
G
---
I
SFPAGSG
L
--
V
A
F
A
AATGVMPLDM
P
E
S
V
L
V
K
FKGKMQPG
I
T
L
R
D
L
V
H
AI---------
P
Y
Y
A
IKEG
D
L
T
V
EKKGKKNI-FS
G
R
I
L
E
I
DLT-EMETDL
T
V
E
Q
A
FELSDASAERSAA
G
C
A
I
T
-L
S
E
E
K
V
A
E
Y
L
R
S
N
I
T
M
L
K
W
M
I
SQGYG
D
A
R
T
M
A
R
R
V
E
N
M
E
K
W
LANPSLLK----ADADA
E
Y
T
K
V
Y
E
I
D
L
S
EIKE
P
I
L
CCPNDP
D
D
A
K
L
L
S
D
VQ------G---------------------------------------D-K
I
D
E
--------
V
F
I
G
S
C
M
T
-N-IG
H
F
R
A
A
G
Q
L
L
E
------K---VP-SGS
L
--
T
T
R
L
W
LAPPTRM
D
E
H
Q
L
M
E
E
GFYNTYGRAGARTEMPGCSLCMG----N-Q--ARV--AP--------N--
T
---
T
V
V
STSTRN
F
P
N
RLG--Q-G--S
N
V
Y
L
A
S
A
E
L
A
S
V
A
A
V
LGKL---------P
T
P
E
E
Y
Q
Q
Y
A
A
Q
I
D
S
M
S
---------
A
D
I
Y
K
YL
N
F
D
QMGEYTNAADKVDT
K
K
I
A
AAQLT
1
PsiBlast_PDB
91.13
74%
-63
- C7 -
-
1L5J
1
ACNB_ECOLI
A:
[1-859]
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
L
L
K
N
P
P
A
G
E
E
E
F
L
L
D
L
L
T
N
R
V
P
P
G
V
D
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
G
G
Y
N
I
H
P
L
I
D
A
L
D
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
F
K
V
T
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
P
D
I
P
L
H
A
L
A
M
L
K
N
A
R
E
G
I
E
P
D
Q
P
G
V
V
G
P
I
K
Q
I
E
A
L
Q
Q
K
G
F
P
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
F
M
G
D
D
I
P
H
V
P
N
K
R
G
G
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
V
S
N
L
N
M
G
D
--
V
I
D
V
Y
P
Y
K
G
E
V
R
N
H
E
T
G
E
L
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
G
R
A
C
G
V
---
K
G
I
R
-
P
G
-
A
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
----
C
-
L
G
-
F
S
A
D
L
V
M
------
Q
S
F
C
---------
H
------
T
A
A
Y
P
K
P
V
---------------
D
V
N
T
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
----
L
-
R
P
G
D
G
V
I
H
S
W
-
L
--
N
R
-----------
M
--
L
L
-
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
F
P
I
---
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
A
T
G
V
M
P
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
L
L
T
V
E
K
K
G
K
K
N
I
-
F
S
G
R
I
L
E
I
----
E
G
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
-
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
E
----
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
Q
------
G
---------------------------------------
E
-
K
I
D
E
--------
V
F
I
G
S
C
M
T
-
N
-
I
G
H
F
R
A
A
G
K
L
L
D
----------
A
H
-
K
G
Q
L
--
P
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
-
Q
--
A
R
V
--
A
D
--------
G
--
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
--
T
-
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
---------
P
T
P
E
E
Y
Q
T
Y
V
A
Q
V
D
K
T
A
---------
V
D
T
Y
R
Y
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
V
-----------
42
Fugue
91.04
74%
-63
- C7 -
-
1L5J
1
ACNB_ECOLI
A:
[1-862]
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
L
L
K
N
P
P
A
G
E
E
E
F
L
L
D
L
L
T
N
R
V
P
P
G
V
D
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
G
G
Y
N
I
H
P
L
I
D
A
L
D
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
F
K
V
T
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
P
D
I
P
L
H
A
L
A
M
L
K
N
A
R
E
G
I
E
P
D
Q
P
G
V
V
G
P
I
K
Q
I
E
A
L
Q
Q
K
G
F
P
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
F
M
G
D
D
I
P
H
V
P
N
K
R
G
G
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
V
S
N
L
N
M
G
D
V
I
D
V
Y
P
Y
K
G
--
E
V
R
N
H
E
T
G
E
L
L
A
T
F
E
L
K
T
D
V
L
I
D
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R
A
G
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
G
R
A
C
G
V
K
G
---
I
R
-
P
G
-
A
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
----
C
-
L
G
-
F
S
A
D
L
V
M
------
Q
S
F
C
---------
H
------
T
A
A
Y
P
K
P
V
---------------
D
V
N
T
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
----
L
-
R
P
G
D
G
V
I
H
S
W
-
L
--
N
R
-----------
M
--
L
L
-
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
F
P
I
---
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
A
T
G
V
M
P
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
L
L
T
V
E
K
K
G
K
K
N
I
-
F
S
G
R
I
L
E
I
E
G
L
-
P
---
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
-
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
E
----
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
Q
------
G
---------------------------------------
E
-
K
I
D
E
--------
V
F
I
G
S
C
M
T
-
N
-
I
G
H
F
R
A
A
G
K
L
L
D
------
A
----
H
-
K
G
Q
L
--
P
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
-
Q
--
A
R
V
--
A
D
--------
G
--
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
--
T
-
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
---------
P
T
P
E
E
Y
Q
T
Y
V
A
Q
V
D
K
T
A
---------
V
D
T
Y
R
Y
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
V
I
F
Q
--------
21
PsiBlast_CBE
91.01
74%
-62
- C7 -
-
1L5J
1
ACNB_ECOLI
B:
[1-859]
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
L
L
K
N
P
P
A
G
E
E
E
F
L
L
D
L
L
T
N
R
V
P
P
G
V
D
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
G
G
Y
N
I
H
P
L
I
D
A
L
D
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
F
K
V
T
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
P
D
I
P
L
H
A
L
A
M
L
K
N
A
R
E
G
I
E
P
D
Q
P
G
V
V
G
P
I
K
Q
I
E
A
L
Q
Q
K
G
F
P
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
F
M
G
D
D
I
P
H
V
P
N
K
R
G
G
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
V
S
N
L
N
M
G
D
--
V
I
D
V
Y
P
Y
K
G
E
V
R
N
H
E
T
G
E
L
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
G
R
A
C
G
V
---
K
G
I
R
-
P
G
-
A
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
----
C
-
L
G
-
F
S
A
D
L
V
M
------
Q
S
F
C
---------
H
------
T
A
A
Y
P
K
P
V
---------------
D
V
N
T
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
----
L
-
R
P
G
D
G
V
I
H
S
W
-
L
--
N
R
-----------
M
--
L
L
-
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
F
P
I
---
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
A
T
G
V
M
P
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
L
L
T
V
E
K
K
G
K
K
N
I
-
F
S
G
R
I
L
E
I
----
E
G
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
-
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
E
----
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
Q
------
G
---------------------------------------
E
-
K
I
D
E
--------
V
F
I
G
S
C
M
T
-
N
-
I
G
H
F
R
A
A
G
K
L
L
D
----------
A
H
-
K
G
Q
L
--
P
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
-
Q
--
A
R
V
--
A
D
--------
G
--
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
--
T
-
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
---------
P
T
P
E
E
Y
Q
T
Y
V
A
Q
V
D
K
T
A
---------
V
D
T
Y
R
Y
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
V
-----------
22
HHSearch
87.85
75%
-41
- C7 -
-
1L5J
1
ACNB_ECOLI
B:
[1-862]
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
L
L
K
N
P
P
A
G
E
E
E
F
L
L
D
L
L
T
N
R
V
P
P
G
V
D
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
G
G
Y
N
I
H
P
L
I
D
A
L
D
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
F
K
V
T
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
P
D
I
P
L
H
A
L
A
M
L
K
N
A
R
E
G
I
E
P
D
Q
P
G
V
V
G
P
I
K
Q
I
E
A
L
Q
Q
K
G
F
P
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
F
M
G
D
D
I
P
H
V
P
N
K
R
G
G
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
V
S
N
L
N
M
G
D
V
I
D
V
--
Y
P
Y
K
G
E
V
R
N
H
E
T
G
E
L
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
G
R
A
C
G
V
K
---
G
I
R
-
P
G
-
A
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
----
C
-
L
G
-
F
S
A
D
L
V
M
------
Q
S
F
C
---------
H
------
T
A
A
Y
P
K
P
V
---------------
D
V
N
T
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
----
L
-
R
P
G
D
G
V
I
H
S
W
-
L
--
N
R
-----------
M
--
L
L
-
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
F
P
I
---
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
A
T
G
V
M
P
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
L
L
T
V
E
K
K
G
K
K
N
I
-
F
S
G
R
I
L
E
I
E
G
---
L
-
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
-
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
E
----
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
Q
------
G
---------------------------------------
E
-
K
I
D
E
--------
V
F
I
G
S
C
M
T
-
N
-
I
G
H
F
R
A
A
G
K
L
L
D
------
A
---
H
K
--
G
Q
L
--
P
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
-
Q
--
A
R
V
--
A
D
--------
G
--
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
--
T
-
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
---------
P
T
P
E
E
Y
Q
T
Y
V
A
Q
V
D
K
T
A
---------
V
D
T
Y
R
Y
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
V
I
F
Q
--------
43
Fugue
50.01
81%
2
- C7 -
-
1L5J
1
ACNB_ECOLI
A:
[380-822]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
F
S
L
A
Q
K
M
V
G
R
A
C
G
V
---
K
G
I
R
-
P
G
-
A
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
----
C
-
L
G
-
F
S
A
D
L
V
M
------
Q
S
F
C
---------
H
TAAYPK------
P
V
---------------
D
V
N
T
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
----
L
-
R
P
G
D
G
V
I
H
S
W
-
L
--
N
R
--------------
M
L
L
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
--
F
P
I
-
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
A
T
G
V
M
P
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
L
L
T
V
E
K
K
G
K
K
N
I
-
F
S
G
R
I
L
E
I
E
-
G
---
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
-
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
E
----
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
Q
------
G
----------------------------------------E
K
I
D
E
--------
V
F
I
G
S
C
M
--
T
N
I
G
H
F
R
A
A
G
K
L
L
D
------
A
-------
H
K
G
QL
P
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
-
Q
--
A
R
----
V
--------
A
DG
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
--
T
-
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
---------
P
T
---------------------------------------------------------
12
PsiBlast_PDB
37.29
38%
-101
- C5 -
-
2JT3
-
TNNC1_HUMAN
A:
[36-66]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
T
K
E
L
G
K
V
M
R
M
L
G
Q
N
---------
P
T
P
E
E
L
Q
E
M
I
D
E
V
D
E
--------------------------------------------
24
HHSearch
35.94
26%
-2
- C7 -
-
4KP2
-
HACA_METJA
A:
[1-418]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
L
V
E
K
I
L
S
K
K
V
G
Y
----
E
V
C
-
A
G
-
D
S
I
E
V
E
V
D
L
A
M
T
H
D
G
T
T
P
L
A
Y
K
A
L
K
E
M
S
----
D
-
S
V
-
W
N
P
D
K
I
V
------
V
A
F
D
---------
H
------
N
V
P
P
N
T
V
K
---------------
A
A
E
M
Q
K
L
A
L
E
F
V
K
R
-
F
G
I
K
N
----
F
H
K
G
G
E
G
I
C
H
Q
I
-
L
--
A
E
-----------
N
Y-
V
L
-
P
N
M
F
V
A
G
G
D
S
H
T
-------
C
T
H
G
AFG
A
---
F
A
T
G
F
G
A
T
D
--
M
A
Y
I
Y
A
T
G
E
T
W
I
K
V
P
K
T
I
R
V
D
I
V
G
K
-
N
E
N
V
S
A
K
D
I
V
L
R
V
---------
C
----
K
--
E
I
------
G
R
R
G
-
A
T
Y
M
A
I
E
Y
G
G
E
-
V
V
-
K
N
M
D
M
D
G
R
L
T
L
C
N
M
A
I
E
M
G
G
K
T
G
V
I
E
-
A
D
E
I
T
Y
-
D
Y
L
K
K
E
R
---------
G
L
S
D
-----
E
D
I
A
K
---
L
-
K
K
E
R
I
T
V
----
N
R
D
E
A
N
Y
Y
K
E
I
E
I
D
I
T
D
M
-
E
E
Q
V
A
V
P
H
H
P
D
N
V
K
P
I
S
D
V
E
------
G
---------------------------------------
T
-
E
I
N
Q
--------
V
F
I
G
S
C
T
N
G
R
-
L
S
D
L
R
E
A
A
K
Y
L
K
------
G
---
R
--
E
V
H
K
--
D
V
K
L
I
V
I
P
A
S
K
K
V
F
L
Q
A
L
K
E
G
I
I
D
I
F
V
K
A
G
A
M
I
C
T
P
G
C
G
P
C
L
G
----
A
-
H
Q-
G
V
L
--
A
E
--------
G
--
E
---
I
C
L
S
T
T
N
R
N
F
K
G
R
M
G
H-
I
-
N
--
S
Y
I
Y
L
A
S
P
K
I
A
A
I
S
A
V
K
G
Y
I
---------
T
N
K
--------------------------------------------------------
4
PsiBlast_PDB
35.67
26%
-8
- C7 -
-
4KP2
-
HACA_METJA
A:
[1-415]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
L
V
E
K
I
L
S
K
K
V
G
Y
E
----
V
C
-
A
G
-
D
S
I
E
V
E
V
D
L
A
M
T
H
D
G
T
T
P
L
A
Y
K
A
L
K
E
M
S
----
D
-
S
V
-
W
N
P
D
K
I
V
------
V
A
F
D
---------
H
------
N
V
P
P
N
T
V
K
---------------
A
A
E
M
Q
K
L
A
L
E
F
V
K
R
-
F
G
I
K
N
----
F
H
K
G
G
E
G
I
C
H
Q
I
-
L
A
-
E
N
-----------
Y
--
V
L
-
P
N
M
F
V
A
G
G
D
S
H
T
CT-----
H
G
A
F
---
G
----
A
F
A
T
G
F
G
A
T
D
M
A
Y
I
Y
A
T
G
E
T
W
I
K
V
P
K
T
I
R
V
D
I
V
G
K
N
E
-
N
V
S
A
K
D
I
V
L
R
V
C
K
E
I
GRRGA
T
Y
M
A
I
E
Y
G
G
E
V
V
-----
K
N
M
D
M
D
G
R
L
T
L
C
N
M
A
I
E
M
G
G
K
T
G
V
I
E
A
D
E
I
T
Y
D
Y
L
K
K
E
R
G
------
L
S
D
E
D
I
A
K
L
K
K
E
R
I
T
V
N
R
-------------------------------------
D
E
A
N
Y
Y
K
E
I
E
I
D
I
T
D
M
E
E
Q
V
-
A
V
P
H
H
P
D
N
V
K
P
I
S
D
V
E
------
G
---------------------------------------
T
-
E
I
N
Q
--------
V
F
I
G
S
C
T
N
G
R
-
L
S
D
L
R
E
A
A
K
Y
L
-------
K
---
G
R
-
E
V
H
K
--
D
V
K
L
I
V
I
P
A
S
K
K
V
F
L
Q
A
L
K
E
G
I
I
D
I
F
V
K
A
G
A
M
I
C
T
P
G
C
G
P
C
L
G
A---
H
-
Q
--
G
V
L
--
A
E
--------
G
--
E
---
I
C
L
S
T
T
N
R
N
F
K
G
R
M
G
--
H
I
N
--
S
Y
I
Y
L
A
S
P
K
I
A
A
I
S
A
V
K
G
Y
I
--------------------------------------------------------------------
25
HHSearch
34.50
22%
10
- C7 -
-
1C96
2
ACON_BOVIN
A:
[29-483]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
N
Q
E
I
E
R
G
K
-
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
----
L
P
K
V
-
A
V
P
S
T
--------
I
H
C
D
---------
H
------
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
-----
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
F
----
W
-
R
P
G
S
G
I
I
H
Q
I
-
I
--
L
E
-----------
N
Y-
A
Y
-
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
GLG
G
---
I
C
I
G
V
G
G
A
D
--
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------
A
----
G
--
I
L
------
T
V
K
G
-
G
T
G
A
I
V
E
Y
H
G
P
-
G
V
-
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
-
Y
N
H
R
M
K
-
K
Y
L
S
K
T
----------
G
R
A
D
I
---
A
N
L
---
A
D
E
F
---
K
D
H
L
V
----
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
WP-------------------------------------
L
-
D
I
R
V
--------
G
L
I
G
S
C
T
N
S
S
-
Y
E
D
M
G
R
S
A
A
V
A
K
------
Q
A
L
A
H
G
L
K
C
----
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
-
W
DR
K
D
I
KK
G
E
--------
K
--
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
AN
P
-
E
--
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
---------
K
F
N
P
E
T
-----------------------------------------------------
26
HHSearch
34.23
22%
8
- C7 -
-
1B0K
2
ACON_PIG
A:
[30-483]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
N
Q
E
I
E
R
G
K
-
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
----
L
P
K
V
-
A
V
P
S
T
--------
I
H
C
D
---------
H
------
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
-----
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
F
----
W
-
R
P
G
S
G
I
I
H
Q
I
-
I
--
L
E
-----------
N
Y-
A
Y
-
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
GLG
G
---
I
C
I
G
V
G
G
A
D
--
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------
A
----
G
--
I
L
------
T
V
K
G
-
G
T
G
A
I
V
E
Y
H
G
P
-
G
V
-
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
-
Y
N
H
R
M
K
-
K
Y
L
S
K
T
----------
G
R
A
D
I
---
A
N
L
---
A
D
E
F
---
K
D
H
L
V
----
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
WP-------------------------------------
L
-
D
I
R
V
--------
G
L
I
G
S
C
T
N
S
S
-
Y
E
D
M
G
R
S
A
A
V
A
K
------
Q
A
L
A
H
G
L
K
C
----
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
-
W
DR
K
D
I
KK
G
E
--------
K
--
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
AN
P
-
E
--
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
---------
K
F
N
P
E
T
-----------------------------------------------------
19
PsiBlast_PDB
34.04
38%
-56
* C5 *
-
1DTL
2
TNNC1_CHICK
A:
[36-73]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
T
K
E
L
G
K
V
M
R
M
L
G
Q
N
---------
P
T
P
E
E
L
Q
E
M
I
D
E
V
D
E
--------------------------------------------
51
Fugue
33.36
19%
-108
- C- -
-
3VIE
-
?
B:
[116-151]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
T
W
E
R
E
I
E
N
Y
T
---------
R
Q
I
Y
R
I
L
E
E
S
Q
E
Q
Q
D
R
N
E
R
D
L
L
E
----------
20
PsiBlast_PDB
33.30
38%
-61
- C5 -
-
1J1D
-
TNNC1_HUMAN
A:
[36-68]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
T
K
E
L
G
K
V
M
R
M
L
G
Q
N
---------
P
T
P
E
E
L
Q
E
M
I
D
E
V
D
E
--------------------------------------------
2
PsiBlast_PDB
32.81
26%
4
- C7 -
-
4NQY
-
LEUC_METJA
A:
[22-442]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
I
V
E
K
I
L
A
K
A
S
G
K
K
E
---
V
S
-
P
G
-
D
I
V
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
----
I
-
E
K
V
W
N
P
E
K
I
V
------
I
L
F
D
-------------------------------------------
N
H
I
L
M
R
K
F
V
K
-
E
Q
G
I
K
Y
F
Y
D
I
-
R
--
E
G
V
C
H
Q
V
-
L
P
E
K
G
-----------
H
--
V
A
-
P
G
E
V
V
V
G
A
D
S
H
T
CTHGAFG
A
F
A
T
---
G
---
I
----
G
S
T
D
--
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
---------
I
------
G
E
V
G
V
D
G
A
T
Y
K
A
C
Q
F
G
G
E
T
V
K
---------
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
-
T
G
I
I
-
E
P
D
E
K
T
I
Q
Y
V
K
E
A
M
--------
K
K
H
G
T
E
R
P
F
--------------
E
V
I
K
----
G
D
E
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
P
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
E
V
A
------
G
---------------------------------------
K
-
P
I
D
Q
--------
V
F
I
G
S
C
T
N
G
R
-
L
E
D
L
R
M
A
I
K
I
I
E
------
K
---
H
G
-
G
I
A
D
--
D
V
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
----
S
-
L
--
Y
G
V
L-
G
P
--------
G
--
E
---
V
C
V
S
T
S
N
R
N
F
R
G
R
Q
G
--
S
L
E
--
A
E
I
Y
L
A
S
P
I
T
A
A
A
C
A
V
K
G
E
L
---------
V
D
P
R
D
------------------------------------------------------
3
PsiBlast_PDB
32.37
26%
-5
- C7 -
-
4KP1
5
LEUC_METJA
A:
[23-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
T
I
V
E
K
I
L
A
K
A
S
G
K
K
E
---
V
S
-
P
G
-
D
I
V
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
----
I
-
E
K
V
W
N
P
E
K
I
V
------
I
L
F
D
---------
H
------
Q
V
P
-
A
D
S
I
---------------
K
A
A
E
N
H
I
L
M
R
K
F
V
K
-
E
Q
G
I
K
Y
F
Y
D
I
-
R
--
E
G
V
C
H
Q
V
-
L
P
E
K
G
-----------
H
--
V
A
-
P
G
E
V
V
V
G
A
D
S
H
T
CTHGAFG
A
F
A
T
---
G
---
I
----
G
S
T
D
--
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
I
G
E
V
GVDGA
T
Y
K
A
C
Q
F
G
G
E
T
V
K
K
M
------------
S
I
A
S
R
-
M
T
M
T
N
M
A
I
E
------------
M
G
G
K
T
G
I
I
-
E
P
D
E
K
T
I
Q
Y
V
K
E
A
--------
M
K
K
H
G
T
E
R
P
F
--------------
E
V
I
K
----
G
D
E
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
P
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
E
V
A
------
G
---------------------------------------
K
-
P
I
D
Q
--------
V
F
I
G
S
C
T
N
G
R
-
L
E
D
L
R
M
A
I
K
I
I
E
------
K
---
H
G
-
G
I
A
D
--
D
V
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
----
S
-
L
--
Y
G
V
L-
G
P
--------
G
--
E
---
V
C
V
S
T
S
N
R
N
F
R
G
R
Q
G
--
S
L
E
--
A
E
I
Y
L
A
S
P
I
T
A
A
A
C
A
V
K
G
E
L
---------
V
D
P
R
D
------------------------------------------------------
27
HHSearch
31.80
22%
15
- C7 -
-
2B3X
2
ACOC_HUMAN
A:
[72-569]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
-
L
G
-
G
D
P
E
K
I
N
PV
C
P
A
D
L
V
I
D
---------
H
------
S
I
Q
V
D
F
N
R
RAD
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
----
I
-
P
P
G
S
G
I
I
H
Q
V
-
N
--
L
E
YLARVVFDQDG
Y
--
Y
Y
-
P
D
S
-
L
V
G
T
D
S
H
T
-------
T
M
I
D
---
G
LG
I
L
G
W
G
V
G
G
I
E
--
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
---------
T
----
K
--
H
L
------
R
Q
V
G
-
V
V
G
K
F
V
E
F
F
G
P
-
G
V
-
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
-
V
D
E
V
S
I
-
T
Y
L
V
Q
T
----------
G
R
D
E
-----
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
DFND
P
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
-
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
------
K
D
F
E
S
C
L
G
AKQGFKGFQVAPEHHN
D
H
K
T
F
I
Y
DN
T
E
F
T
L
A
H
G
-
S
V
V
I
--------
A
A
I
T
S
C
T
N
T
S
-
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
---
L
--
N
V
M
P
--
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
-
S
--
G
P
L
--
P
E
P
V
V
E
A
I
T
Q
G
--
D
LV
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P-
N
-
T
--
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
---------
R
I
D
F
-------------------------------------------------------
23
HHSearch
31.55
26%
22
- C7 -
-
4KP1
5
LEUC_METJA
A:
[23-445]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
T
I
V
E
K
I
L
A
K
A
S
G
K
K
---
E
V
S
-
P
G
-
D
I
V
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
----
I
E
K
V
-
W
N
P
E
K
I
V
------
I
L
F
D
---------
H
------
Q
V
P
A
D
S
I
K
---------------
A
A
E
N
H
I
L
M
R
K
F
V
K
E
-
Q
G
I
K
Y
----
F
Y
D
I
R
E
G
V
C
H
Q
V
-
L
--
P
E
-----------
K
GH
V
A
-
P
G
E
V
V
V
G
A
D
S
H
T
-------
C
T
H
G
---
A
FGA
F
A
T
G
I
G
S
T
D
--
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
---------
I
----
G
--
E
V
------
G
V
D
G
-
A
T
Y
K
A
C
Q
F
G
G
E
-
T
V
-
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
-
P
D
E
K
T
I
-
Q
Y
V
K
E
A
M
----------
K
K
H
-----
G
T
---
E
R
P
F
----
E
V
I
K
----
G
D
E
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
P
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
E
V
A
------
G
---------------------------------------
K
-
P
I
D
Q
--------
V
F
I
G
S
C
T
N
G
R
-
L
E
D
L
R
M
A
I
K
I
I
E
------
K
---
H
G
-
G
I
A
D
--
D
V
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
----
S
L
Y
--
G
V
L
--
G
P
--------
G
--
E
---
V
C
V
S
T
S
N
R
N
F
R
G
R
Q
G
S-
L
-
E
--
A
E
I
Y
L
A
S
P
I
T
A
A
A
C
A
V
K
G
E
L
---------
V
D
P
R
D
L
-----------------------------------------------------
28
HHSearch
31.14
22%
15
- C7 -
-
2B3Y
2
ACOC_HUMAN
B:
[72-569]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
DAVK
K
-
L
G
-
G
D
P
E
K
I
N
PVCPAD
L
V
I
D
---------
H
------
S
I
Q
V
D
F
N
R
RADSLQKNQDLEFER
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
----
I
-
P
P
G
S
G
I
I
H
Q
V
-
N
--
L
E
YLARVVFDQDG
Y
--
Y
Y
-
P
D
S
-
L
V
G
T
D
S
H
T
-------
T
M
I
D
---
G
LGI
L
G
W
G
V
G
G
I
E
--
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
---------
T
----
K
--
H
L
------
R
Q
V
G
-
V
V
G
K
F
V
E
F
F
G
P
-
G
V
-
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
-
V
D
E
V
S
I
-
T
Y
L
V
Q
T
----------
G
R
D
E
-----
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
DFND
P
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
-
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
------
K
DFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAH
G
-
S
V
V
I
--------
A
A
I
T
S
C
T
N
T
S
-
N
P
S
V
M
L
G
A
G
L
L
A
KKAVDA
G
---
L
--
N
V
M
P
--
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
-
S
--
G
P
L
--
P
E
PVVEAITQ
G
--
D
LVA
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P-
N
-
T
--
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
---------
R
I
D
F
-------------------------------------------------------
44
Fugue
30.83
19%
23
- C7 -
-
1ACO
1
?
?:
[2-528]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
V
A
M
S
H
F
E
P
H
E
Y
I
R
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
----
L
-
P
K
-
V
A
V
P
S
T
I
------
H
C
D
H
L
I
E
A
Q
LGG
E
K
------
D
L
R
R
A
K
D
I
---------------
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
F
----
W
-
R
P
G
S
G
I
I
H
Q
I
I
L
--
E
N
-----------
Y
--
A
Y
-
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
---
G
LG
G
I
C
I
G
V
G
G
A
D
--
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------
A
G
I
L
T
V
K
G
G
-------------
T
G
A
I
V
E
Y
H
G
P
-
G
V
D
S
-
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
-
Y
N
-
H
R
M
K
K
Y
L
S
K
-------------------
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
L
V
----
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------
S
---------------------------------------
V
-
A
E
K
E
GWPLDIR
V
G
L
I
G
S
C
T
N
-
S
S
Y
E
D
M
G
R
S
A
A
V
A
K
------
Q
---
A
L
-
A
H
G
L
KC
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
QWDR
K
-
D
--
I
K
K
--
G
E
--------
K
--
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
--
A
-
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
KFNPE
T
D
F
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
LPRAEFDPG
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
------------------
11
PsiBlast_PDB
29.91
38%
-56
- C5 -
-
1LA0
-
TNNC1_CHICK
A:
[36-66]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
T
K
E
L
G
K
V
M
R
M
L
G
Q
N
---------
P
T
P
E
E
L
Q
E
M
I
D
E
V
D
E
--------------------------------------------