@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM63: (2017-11-06 )
MTDEKLTQRRIHTLDAALANQIAAGEVIERPSSVVKELLENSIDAGATELIVRIAQGGSTLIEIIDNGHGIHPDDLPLAVMRHATSKIKTAEDLHAIVSLGFRGEALASIAAVSRLTLTSSQDESGIGHQVEVNGTAFDHQQVQAVAAQKGTHIRVQDLFFNVPARRKFLKKPTTEFGHIEEIVRRLALTHFDIRFVLEHNDNIRINLPIADSGELRFQRVQQLLGQQFVQNAYWIDAESINMRLSGWLGHPSDARAQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQHSSYLLFLEVDPENIDVNVHPTKHEIRFLNQREVHEFVRHYAKETLAQFQTASADLAQAMKVDDTQNLSVQPQPKYQEQFTLHRTAQAADTAVDKPNGYQPSTELLTDFNNSRPQSVHYAEQTPKYNGSAQLNNALKTYLAPLRDQPANFSVDESIEPVPKVDEFPLGIAIAQLHGIYILAQNTEGLIIVDMHAAHERILLKQMKNAWDKPEFWTSQQLLIPKVISISRMQAVRVEDLKPQLERLGLEIDLYGDEQVIVRGVPAILQKADFENLIPELLNDLDPNDEAQGLLQKRDELLAGMACHGAVRAHRQLSLSEMNALLRQMEQTEFASQCNHGRPTWRAFPLSQLDKLFARGE
Atome Classification :
(21 SA)
.........10........20.....-..---.30........40........50........60........70........80........90.....---...100.......110.......120--------.......130..-..-..-.140......---.150.......160......-.170-.-.......180.......190.......200-------------..-----.-----.....-.210.....-..220.......230---......------------------.240..----......250.--.--..-...260.......270.......280.......290.......300.......310.......320.......330----........340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500........510.......520.......530.......540.......550.......560.......570..--.....580.......590.......600.......610------------------........620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
D
E
K
L
T
Q
R
R
I
H
T
L
D
A
A
L
A
N
Q
IAA
G
E
-
V
I---ER
P
S
S
V
V
K
E
L
L
ENSIDA
G
A
T
E
L
I
V
RIAQGG
S
T
L
I
E
I
IDNGHGIHP
D
D
L
P
L
A
V
M
R
H
A
TSKI
K
T
A
E
D
L
H
A
---
I
V
SLGFR
G
E
A
L
A
S
I
A
A
V
S
R
L
T
L
TSSQ--------DESGIG
H
Q
V
E
VN-GT-AF-
D
H
Q
Q
V
Q
A
V
A
A---QKG
T
H
I
R
V
Q
D
L
F
FN
V
P
A
R
R
K
-
F
L-K-K-PTTEFG
H
I
E
E
I
V
R
R
L
A
LT
H
F
D
I
R
F
V
L
EH---------------ND-----
N
-----
I
R
I
N
L
-PIADSG
E
L
R
-
F
Q
R
V
Q
Q
L
L
G
Q
Q
F
V
Q
N---
A
Y
W
I
DA------------------E
S
I
-
N
M
----
R
L
S
GWLGHPS--D--AR-AQ
A
D
L
Q
Y
V
Y
VN
G
R
I
VK
D
K
T
I
S
H
A
L
R
M
A
Y
D
G
I
LHGHQHS
S
Y
L
L
F
L
E
VDPEN
I
D
V
N
VHPT
K
H
E
I
R
F
L
N
Q
R
E
V
H
E
F
V
R
-----
H
Y
A
K
E
T
L
A
Q
F
Q
T
A
S
A
D
L
A
Q
A
MKVDDTQNLSVQPQP
K
Y
Q
E
Q
F
T
LHRTAQAADTAVDKPNGYQP
S
T
E
L
L
T
DFNNSRPQSVHYAEQTPKYNG
S
A
Q
L
N
N
A
L
K
T
Y
L
A
P
LRDQPANFSVDESIEPVPKVDEFP
L
G
I
A
I
A
QL
H
G
I
Y
I
L
A
QNTE
G
L
I
I
V
DM
H
A
A
H
E
R
I
L
L
K
Q
M
K
N
AWD-KPEFWTSQQ
L
L
I
P
K
V
I
S
I
S
R
M
Q
A
V
R
V
E
D
L
K
P
Q
L
E
RLG
L
E
I
D
L
YGD
E
Q
V
I
V
R
G
V
P
A
I
L
Q
KA
D
F
E
N
L
I
P
E
L
L
N
DL--DP
N
D
E
A
Q
G
L
L
Q
K
R
D
E
L
L
A
G
M
A
C
H
G
A
V
R
A
H
R
QL
S
L
S
E
M
-------------------
N
A
L
L
R
Q
M
E
Q
T
E
F
A
S
QCNHGRPTWRAF
P
L
S
Q
L
D
K
L
FARGE
4
PsiBlast_PDB
86.29
46%
-82
- C2 -
-
1B62
1
MUTL_ECOLI
A:
[9-337]
----------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
E
-
G
R
-
D
M
-
N
-
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
--
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
-----
Q
G
V
L
S
V
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.70
48%
-77
- C2 -
-
1NHJ
1
MUTL_ECOLI
A:
[5-324]
----------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
P
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
E
-
G
R
-
D
M
-
N
-
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.79
49%
-76
- C2 -
-
1NHI
3
MUTL_ECOLI
A:
[5-324]
----------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
E
-
G
R
-
D
M
-
N
-
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.72
49%
-75
- C2 -
-
1B63
3
MUTL_ECOLI
A:
[5-324]
----------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
E
-
G
R
-
D
M
-
N
-
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
79.43
48%
-25
- C2 -
-
1B63
3
MUTL_ECOLI
A:
[2-332]
-------
H
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
E
-
G
R
-
D
M
N
V
T
V
K
P
A
--
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
T-
T
P
-
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
-----
Q
G
V
L
S
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.17
49%
-77
- C2 -
-
1NHH
6
MUTL_ECOLI
A:
[5-324]
----------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
E
-
G
R
-
D
M
-
N
-
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
---
Q
K
-
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
--
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.93
47%
-99
- C2 -
-
5AKC
-
MUTL_ECOLI
C:
[40-351]
----------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
----------
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
L
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
-----
Q
G
V
L
S
V
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.25
47%
-107
- C2 -
-
5AKD
-
MUTL_ECOLI
C:
[40-351]
----------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
----------
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
L
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
-----
Q
G
V
L
S
V
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.57
47%
-96
- C2 -
-
5AKB
-
MUTL_ECOLI
C:
[40-351]
----------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
----------
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
L
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
-----
Q
G
V
L
S
V
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
75.28
48%
11
- C2 -
-
1B63
3
MUTL_ECOLI
A:
[1-333]
------
S
H
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
-
E
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
E
-
G
R
-
D
M
-
N
V
-
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
---
R
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
-------GK---
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
-G
D
L
----
T
L
R
G
W
V
A
D
P
N
---HT
T
P
-
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
-----
Q
G
V
L
S
V
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.09
46%
-99
- C2 -
-
1BKN
-
MUTL_ECOLI
A:
[20-331]
----------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
----------
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
----------------
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
-----
Q
G
V
L
S
V
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
64.11
26%
-29
- C2 -
-
3H4L
2
PMS1_YEAST
B:
[8-362]
------------
Q
I
N
D
I
D
V
H
R
I
T
S
G
Q
-
V
I
---
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
K
H
Y
T
S
K
I
A
K
F
Q
D
V
A
K
---
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
T
T
--------
S
P
-
P
K
A
D
K
L
E
Y
D
M
V
G
-
H
I
-
T
S
K
T
T
T
--
S
R
---
N
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
-
E
F
-
S
K
T
-
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
I
N
A
A
I
K
F
S
V
W
N
---------------
I
T
-----
P
KGKKN
L
I
L
S
T
-
M
R
N
---
S
S
M
-
R
K
N
I
S
S
V
F
G
A
G
G
M
R
G
---
L
E
E
V
D
L
V
L
DLNPFKNRMLLD----
L
D
Y
-
K
I
----
R
V
K
G
Y
I
S
Q
N
S
--
F
GC
G
R
-
N
S
K
D
R
Q
F
I
Y
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
T
F
N
-
N
V
Q
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
----
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
-----
T
T
L
S
D
Y
Y
N
R
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
62.74
52%
-83
- C2 -
-
1B63
3
MUTL_ECOLI
A:
[3-218]
--------
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
E
-
G
R
-
D
--
M
N
V
T
V
K
P
A
A
H
---
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
G
-----
K
-----
I
V
R
Q
Y
-
R
A
V
P
E
G
G
Q
K
-
E
R
R
L
G
A
I
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
59.89
24%
-29
- C2 -
-
1H7S
-
PMS2_HUMAN
A:
[29-364]
------------------------
G
Q
-
V
V
---
L
S
L
S
T
A
V
K
E
L
V
E
N
S
L
D
A
G
A
T
N
I
D
L
K
L
K
D
Y
G
V
D
L
I
E
V
S
D
N
G
C
G
V
E
E
E
N
F
E
G
L
T
L
----------
A
D
L
T
Q
---
V
E
T
F
G
F
R
G
E
A
L
S
S
L
C
A
L
S
D
V
T
I
S
T
C
H
--------
A
S
A
K
V
G
T
R
L
M
F
D
-
H
N
G
K
I
-
I
Q
K
T
P
Y
--
P
R
---
P
R
G
T
T
V
S
V
Q
Q
L
F
S
T
L
P
V
R
H
K
-
E
F
Q
R
-
N
-
I
K
K
E
Y
A
K
M
V
Q
V
L
H
A
Y
C
I
I
S
A
G
I
R
V
S
C
T
N
---------------
Q
L
GQGKR
Q
-----
P
V
V
C
T
-
G
G
S
---
P
S
I
-
K
E
N
I
G
S
V
F
G
Q
K
Q
L
Q
S
---
L
I
P
F
V
Q
L
P
PS
D
S
V
C
E
E
Y
GLSCSDA
L
H
N
-
L
F
----
Y
I
S
G
F
I
S
Q
C
T
--
H
GV
G
R
-
S
S
T
D
R
Q
F
F
F
I
N
R
R
P
C
D
P
A
K
V
C
R
L
V
N
E
V
Y
H
M
Y
-
N
R
H
Q
Y
P
F
V
V
L
N
I
S
V
D
S
E
C
V
D
I
N
------
Q
I
L
L
Q
E
E
K
L
L
L
A
V
L
K
-----
T
S
L
I
G
M
F
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
53.90
27%
-7
- C2 -
-
3H4L
1
PMS1_YEAST
A:
[13-364]
-----------------
D
V
H
R
I
T
S
G
Q
-
V
I
---
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
K
H
Y
T
---------
A
K
---
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
T
T
SPP
K
A
D
K
L
E
Y
D
M
V
G
H
I
T
S
K
T
-
T
T
------------
S
R
---
N
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
E
F
S
-
K
-
T
-
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
I
N
A
A
I
K
F
S
V
W
N
I
T
PK
G
K
K
N
L
I
L
S
T
M
R
N
S
-----
S
-----
M
R
K
N
I
S
S
V
F
G
A
G
G
M
R
G
L
E
E
V
D
L
V
L
D
L
N
P
F
K
N
RML------------------------------DY
K
I
R
V
K
G
Y
I
S
Q
N
S
FG
C
--
G
R
-
N
S
K
D
R
Q
F
I
Y
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
-
T
F
N
N
V
Q
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
V
N
V
T
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
T
T
L
S
D
Y
Y
N
R
Q
E
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
47.62
53%
41
- C2 -
-
1B63
3
MUTL_ECOLI
A:
[1-204]
---
S
H
M
P
I
Q
---
V
L
P
P
Q
L
A
N
Q
I
A
A
G
----
E
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
-
A
II--
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
--------
A
E
Q
Q
E
A
W
Q
A
Y
A
E
-
G
R
-
D
M
-
N
V
-
T
-
V
K
P
A
-
A
H
P
-
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
---
R
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---------------
N
---------------
G
K
-
I
V
R
Q
Y
R
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
47.56
19%
-145
- C1 -
-
1X9Z
2
B:
[5-186]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
S
F
G
R
V
L
T
I
V
H
S
D
C
A
L
L
E
R
D
G
N
I
S
L
L
S
L
P
V
A
E
R
W
L
R
Q
A
Q
L
T
P
G
E
A
----
P
V
C
A
Q
P
L
L
I
P
L
R
L
K
V
S
A
E
E
K
S
A
L
E
K
A
Q
S
A
L
A
E
L
G
I
D
F
Q
S
D
-
A
Q
H
V
T
I
R
A
V
P
L
P
L
R
Q
Q
N
L
Q
I
L
I
P
E
L
I
G
Y
L
--
A
K
Q
S
V
F
----
E
-
P
G
N
I
A
Q
W
I
A
R
N
L
M
S
E
-
H
A
Q
W
S
M
A
Q
A
I
T
L
L
A
D
V
E
R
L
C
P
Q
L
V
K
T
PP
G
G
L
L
Q
S
V
D
L
H
P
A
I
K
A
L
K
----------------------
12
PsiBlast_PDB
45.01
33%
-21
- C1 -
-
3GAB
-
MUTL_BACSU
A:
[435-624]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E-
P
E
V
---
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
---
R
E
E
A
A
I
M
M
S
C
K
-----
N
R
H
L
R
N
D
E
I
-------------------
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
---
29
Fugue
42.06
40%
-53
- C2 -
-
1B63
3
MUTL_ECOLI
A:
[219-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
F
L
E
Q
---
A
L
A
I
E
W
------------------
Q
H
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
-----
Q
G
V
L
S
V
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
41.33
29%
-130
* C1 *
-
5B42
2
A:
[2-102]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
T
Y
E
I
L
G
Q
M
D
E
T
F
I
L
V
K
D
S
E
Y
L
Y
F
V
D
Q
H
L
L
E
E
R
I
N
Y
E
K
L
K
D
E
------------------------------------------------------------------------------------------------
N
L
A
C
R
I
S
V
K
A
G
Q
K
L
S
E
E
K
I
-------------------
R
E
L
I
K
T
W
R
N
L
E
N
P
H
V
C
P
H
G
R
P
I
Y
Y
K
I
P
L
R
E
I
Y
E
K
V
G
R
N
Y
30
Fugue
38.24
38%
-40
- C2 -
-
1B63
3
MUTL_ECOLI
A:
[219-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
F
-
L
E
Q
A
L
A
I
E
W
Q
H
---------------------------------
G
-
D
L
----
T
L
R
G
W
V
A
D
P
N
---HT
T
P
-
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
-----
Q
G
V
L
S
V
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------