@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM88: (2017-11-06 )
MNIAAQPPVQADQTVYLKDYQKPVFLVESINLDIQVYDDKTIVDSTLVMKRQTAGDLVLLGRDLELQSIQLNGQDLTPAQYSLDSEQLVITDAPDEVILQTQVIIHPETNTQLEGLYKAGDLFVTQNEPEGFRKITFYPDRPDVLSVFTTRVEADKKYPVLLANGNLLETGEVGENRHFAIWQDPTKKPSYLFACVIGDLAVLKDRYTTSEGREVALEIYAIEKDIPKCHIAMEALKHSMRWDEEHYGRAYDLDNYMIVAVSQFNMGAMENKGLNIFNTSCVLADEEYTTDAAIMRVQSVIAHEYFHNWTGNRITCRDWFQLCLKEGLTVFRDQSFSEDLQSAAVQRIDDVAVLKSHQFPEDAGPLSHPPRPDHFVEINNFYTATVYEKGAEINRMMSTLLGKEKFRQGTDEYFRRHDGQAVTVEDWVAALSAGSGVDLSAFLTWYNQPGTPKVEAKGEYDAAAQTYRLSFKQSLKAHPKYPNLKAVPIPVALALFNAKTGEQYTLQSESLFVNGVKDGVYLFDQDEATIEFTGVTEQPVVSLLRNFSAPVNLVFDYTDEELAFLIQHETNGFNQWQATQTLLERILLEDHSADAYIQAIQSTLPELVSRAPLLASRLFDVPTEGYLGSRIDQNYAPADIHVKREALLNRLAQELGSFWKDTYLTLDPDLQKEFSLAMGVRALKNIMLMMMARQGDQSAFELAYEQYQSTGNMSERLGALRVLVWQSAPQAQEALADFYNRFKDEALSLDQWFMIQAANPNATVETIEYLTQHPDYDLTTPNRIRAVSGGLSNNPENTWGFGVAHFINLAEYLDEKNPILGSRLLQVLSRWYTLAEPQRTQVQQALQALQPKVKSKNVSETLNSMLSI
Atome Classification :
(65 SA)
.........10........20........30........40........---50.--.---...--...60........70......-..80.........90-..---.--.....100.......110.......120.......130.......140.......150....-.--..160.......170.......180.......190.......200.......210........220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430------.....-------...440.......450.......460.......470.......480.......490......-.500.......510.......520.......530.......540.......550.......560.......570.......------580.--------------.----------------------------.....590------------------.----------..------....600.......610.---......620-........630.......640.......650.......660....-...670----....---...---..680.......690.......700.......710.......720.......730.......740.......750.-......760-.-.-.....770.......780.......790.....----..----800.......810.---......820.......830..-.....840.......850...-.....860......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNIAAQPPVQAD
Q
T
V
Y
L
KDYQK
P
V
F
L
V
E
SI
N
L
D
I
Q
V
YDDKTIV
D
S
T
L
V
M
---KRQ--T---AG
D
--
L
V
L
LGRD
L
E
L
Q
S
I
Q
LNGQDLT-PAQ-YSLDSE
Q
L
V
I
T-DA---P--D
E
V
I
L
Q
T
Q
V
I
I
HPETNT
Q
L
E
G
L
Y
KA
G
D
L
F
V
TQNEPEG
F
R
K
I
TFYPDR
P
D
V
L
S
V
F
T
T
RVEADK-K--Y
P
V
L
L
ANG
N
L
L
ETGEVGENR
H
F
A
I
WQDPTKKP
S
Y
L
F
A
C
VIG
D
L
A
V
L
KDRYTTS-EG
R
E
V
A
L
E
I
Y
A
IEKDI
P
K
C
H
I
A
M
E
A
L
K
H
SMRW
D
E
E
HYG
R
A
YDLD
N
Y
M
I
V
A
V
S
QFNMGAMENKG
L
N
I
FN
T
S
C
V
L
ADEEYT
T
D
A
A
I
M
R
V
Q
S
V
I
A
H
E
Y
F
HNWTG
N
R
I
T
C
R
D
W
F
Q
L
C
L
KEG
L
T
V
FRDQ
S
F
S
E
D
L
Q
S
A
A
V
Q
R
I
D
D
V
A
V
L
K
SHQFPEDAGPLSHPPRPD
H
F
V
E
IN
N
F
Y
T
A
T
V
Y
EKG
A
E
I
N
R
M
M
S
T
L
L
G
K
E
K
F
R
Q
G
T
D
E
Y
F
R
RHDG
Q
A
V
T
V
E
D
W
V
A
A
L-------SAGSG-------
V
D
L
S
A
F
L
T
W
YNQPGTP
K
V
E
AKGEYDAA
A
Q
T
Y
R
L
S
F
K
Q
S
LKAHPKYPNLKAV
P
I
P
V
A
L
A
LFNA-KTG
E
Q
Y
T
LQSE
S
L
F
V
NGVKD
G
V
Y
L
F
DQDE
A
T
I
E
F
TGV
T
E
Q
P
V
V
S
L
L
R
NFSA
P
V
N
L
V
F
DYTD
E
E
L
A
F
L
I
QHETNGF
N
Q
W
Q
A
T
------
Q
T
L
L
--------------
E
----------------------------
R
I
L
LEDHS------------------
A
----------
D
A
------
Y
I
Q
A
I
Q
S
T
L
P
E
L
V
S
RA
P
L
---
L
A
S
R
L
FDV--PTEGYLGSRIDQNYAPAD
I
H
V
K
R
E
A
L
L
N
R
L
A
Q
E
L
G
S
F
W
K
D
T
Y
L
T
L-D
P
D
L
------
Q
K
E
F
---
S
L
A
---
M
G
V
R
A
L
K
N
I
M
L
M
M
M
ARQGD
Q
S
A
F
E
L
A
Y
E
Q
Y
Q
STG
N
M
S
E
R
L
G
A
L
R
V
L
VWQSAP
Q
A
Q
E
A
L
A
D
F
Y
N
R
F
K
D
EALSL
D
Q
W
F
-
M
I
Q
AANPNA-
T
-
V
-
E
T
I
E
Y
L
T
QHPDYDLTTPN
R
I
R
AVSGGLSNNPE
N
----
T
W
----
G
F
G
V
A
H
F
I
N
L
A
E
Y
L---DEKNP
I
L
G
S
R
L
L
Q
V
L
S
R
W
Y
TL-AE
P
Q
R
T
Q
V
Q
Q
A
L
Q
A
L
Q
P
-KVK-SK
N
V
S
E
T
L
N
S
M
LSI
65
Fugue
90.04
40%
11
- C3 -
-
3B34
9
AMPN_ECOLI
A:
[26-891]
-----------
P
Q
A
K
Y
R
H
D
Y
R
A
P
D
Y
Q
I
T
D
I
D
L
T
F
D
L
D
A
Q
K
T
V
V
T
A
V
S
Q
A
---
V
R
H
--
G
---
A
S
D
A
P
L
R
L
N
G
E
D
L
K
L
V
S
V
H
I
N
D
E
P
W
T
-
A
---
W
K
E
E
E
G
A
L
V
I
S
-
N
L
---
P
--
E
R
F
T
L
K
I
I
N
E
I
S
P
A
A
N
T
A
L
E
G
L
Y
Q
S
G
D
A
L
C
T
Q
C
E
A
E
G
F
R
H
I
T
Y
Y
L
D
R
P
D
V
L
A
R
F
T
T
K
I
I
A
D
K
I
K
--
Y
P
F
L
L
S
N
G
N
R
V
A
Q
G
E
L
E
N
G
R
H
W
V
Q
W
Q
D
P
F
P
K
P
C
Y
L
F
A
L
V
A
G
D
F
D
V
L
R
D
T
F
T
T
R
-
S
G
R
E
V
A
L
E
L
Y
V
D
R
G
N
L
D
R
A
P
W
A
M
T
S
L
K
N
S
M
K
W
D
E
E
R
F
G
L
E
Y
D
L
D
I
Y
M
I
V
A
V
D
F
F
N
M
G
A
M
E
N
K
G
L
N
I
F
N
S
K
Y
V
L
A
R
T
D
T
A
T
D
K
D
Y
L
D
I
E
R
V
I
G
H
E
Y
F
H
N
W
T
G
N
R
V
T
C
R
D
W
F
Q
L
S
L
K
E
G
L
T
V
F
R
D
Q
E
F
S
S
D
L
G
S
R
A
V
N
R
I
N
N
V
R
T
M
R
G
L
Q
F
A
E
D
A
S
P
M
A
H
P
I
R
P
D
M
V
I
E
M
N
N
F
Y
T
L
T
V
Y
E
K
G
A
E
V
I
R
M
I
H
T
L
L
G
E
E
N
F
Q
K
G
M
Q
L
Y
F
E
R
H
D
G
S
A
A
T
C
D
D
F
V
Q
A
M
-------
E
D
A
S
N
-------
V
D
L
S
H
F
R
R
W
Y
S
Q
S
G
T
P
I
V
T
V
K
D
D
Y
N
P
E
T
E
Q
Y
T
L
T
I
S
Q
R
T
P
A
T
P
D
Q
A
E
K
Q
P
L
H
I
P
F
A
I
E
L
Y
D
--
N
E
G
K
V
I
P
L
Q
K
G
----
G
H
P
V
N
S
V
L
N
V
T
Q
A
E
Q
T
F
V
F
D
N
V
Y
F
Q
P
V
P
A
L
L
C
E
F
S
A
P
V
K
L
E
Y
K
W
S
D
Q
Q
L
T
F
L
M
R
H
A
R
N
D
F
S
R
W
D
A
A
------
Q
S
L
L
--------------
A
----------------------------
T
Y
I
K
L
N
V
A
------------------
R
----------
H
Q
Q
GQ
P
L
S
L
P
V
H
V
A
D
A
F
R
A
V
L
L
D
E
K
I
D
P
A
L
A
A
E
I
L
T
L
--
P
S
V
N
E
M
A
E
L
F
D
I
I
D
-
P
I
A
I
A
E
V
R
E
A
L
T
R
T
L
A
T
E
L
A
D
E
L
L
A
I
Y
N
A
N
-
Y
Q
S
E
------
Y
R
V
E
---
H
E
D
---
I
A
K
R
T
L
R
N
A
C
L
R
F
L
A
F
G
E
T
H
L
A
D
V
L
V
S
K
Q
F
H
E
A
N
N
M
T
D
A
L
A
A
L
S
A
A
V
A
A
Q
L
P
C
R
D
A
L
M
Q
E
Y
D
D
K
W
H
Q
N
G
L
V
M
D
K
W
F
-
I
L
Q
A
T
S
P
A
A
N
V
-
L
-
E
T
V
R
G
L
L
Q
H
R
S
F
T
M
S
N
P
N
R
I
R
S
L
I
G
A
F
A
G
S
N
P
A
----
A
F
H
AED
G
S
G
Y
L
F
L
V
E
M
L
T
D
L
---
N
S
R
N
P
Q
V
A
S
R
L
I
E
P
L
I
R
L
K
R
Y
-
D
A
K
R
Q
E
K
M
R
A
A
L
E
Q
L
K
G
-
L
E
N
L
S
G
D
L
Y
E
K
I
T
K
A
L
A
-
3
PsiBlast_PDB
90.02
41%
15
- C3 -
-
2DQM
1
AMPN_ECOLI
A:
[4-852]
----------
Q
P
Q
A
K
Y
R
H
D
Y
R
A
P
D
Y
Q
I
T
D
I
D
L
T
F
D
L
D
A
Q
K
T
V
V
T
A
V
S
Q
A
---
V
R
H
--
G
---
A
S
D
A
P
L
R
L
N
G
E
D
L
K
L
V
S
V
H
I
N
D
E
P
W
T
-
A
---
W
K
E
E
E
G
A
L
V
I
S
-
N
L
---
P
--
E
R
F
T
L
K
I
I
N
E
I
S
P
A
A
N
T
A
L
E
G
L
Y
Q
S
G
D
A
L
C
T
Q
C
E
A
E
G
F
R
H
I
T
Y
Y
L
D
R
P
D
V
L
A
R
F
T
T
K
I
I
A
D
K
I
K
--
Y
P
F
L
L
S
N
G
N
R
V
A
Q
G
E
L
E
N
G
R
H
W
V
Q
W
Q
D
P
F
P
K
P
C
Y
L
F
A
L
V
A
G
D
F
D
V
L
R
D
T
F
T
T
R
-
S
G
R
E
V
A
L
E
L
Y
V
D
R
G
N
L
D
R
A
P
W
A
M
T
S
L
K
N
S
M
K
W
D
E
E
R
F
G
L
E
Y
D
L
D
I
Y
M
I
V
A
V
D
F
F
N
M
G
A
M
E
N
K
G
L
N
I
F
N
S
K
Y
V
L
A
R
T
D
T
A
T
D
K
D
Y
L
D
I
E
R
V
I
G
H
E
Y
F
H
N
W
T
G
N
R
V
T
C
R
D
W
F
Q
L
S
L
K
E
G
L
T
V
F
R
D
Q
E
F
S
S
D
L
G
S
R
A
V
N
R
I
N
N
V
R
T
M
R
G
L
Q
F
A
E
D
A
S
P
M
A
H
P
I
R
P
D
M
V
I
E
M
N
N
F
Y
T
L
T
V
Y
E
K
G
A
E
V
I
R
M
I
H
T
L
L
G
E
E
N
F
Q
K
G
M
Q
L
Y
F
E
R
H
D
G
S
A
A
T
C
D
D
F
V
Q
A
M
-------
E
D
A
S
N
-------
V
D
L
S
H
F
R
R
W
Y
S
Q
S
G
T
P
I
V
T
V
K
D
D
Y
N
P
E
T
E
Q
Y
T
L
T
I
S
Q
R
T
P
A
T
P
D
Q
A
E
K
Q
P
L
H
I
P
F
A
I
E
L
Y
D
N
-
E
-
G
K
V
I
P
L
Q
K
G
G
H
P
V
N
S
V
L
N
----
V
T
Q
A
E
Q
T
F
V
F
D
N
V
Y
F
Q
P
V
P
A
L
L
C
E
F
S
A
P
V
K
L
E
Y
K
W
S
D
Q
Q
L
T
F
L
M
R
H
A
R
N
D
F
S
R
W
D
A
A
------
Q
S
L
L
A
T
Y
I
K
L
N
V
A
R
H
Q
Q
G
Q
----------------------------
P
L
S
L
P
V
H
V
------------------
A
----------
D
A
------
F
R
A
V
L
---
L
D
E
K
I
D
--
P
A
---
L
A
A
E
I
L
T
L
--
P
S
V
N
E
M
A
E
L
F
D
I
-
I
D
P
I
A
I
A
E
V
R
E
A
L
T
R
T
L
A
T
E
L
A
----
D
E
L
L
A
I
Y
N
A
N
Y
------
Q
S
E
Y
---
R
V
E
H
E
D
I
A
K
R
T
L
R
N
A
C
L
R
F
L
A
F
G
E
T
H
L
A
D
V
L
V
S
K
Q
F
H
E
A
N
N
M
T
D
A
L
A
A
L
S
A
A
V
A
A
Q
L
P
C
R
D
A
L
M
Q
E
Y
D
D
K
W
H
Q
N
G
L
V
M
D
K
W
F
-
I
L
Q
A
T
S
P
A
A
-
N
-
V
L
E
T
V
R
G
L
L
Q
H
R
S
F
T
M
S
N
P
N
R
I
R
S
L
I
G
A
F
A
G
S
N
P
A
----
A
F
H
AED
G
S
G
Y
L
F
L
V
E
M
L
T
D
L
---
N
S
R
N
P
Q
V
A
S
R
L
I
E
P
L
I
R
L
K
R
Y
-
D
A
K
R
Q
E
K
M
R
A
A
L
E
Q
L
K
--------------------
18
PsiBlast_PDB
89.64
41%
16
- C3 -
-
5MFS
7
AMPN_ECOLI
A:
[24-873]
---------
Q
Q
P
Q
A
K
Y
R
H
D
Y
R
A
P
D
Y
Q
I
T
D
I
D
L
T
F
D
L
D
A
Q
K
T
V
V
T
A
V
S
Q
A
---
V
R
H
--
G
---
A
S
D
A
P
L
R
L
N
G
E
D
L
K
L
V
S
V
H
I
N
D
E
P
W
T
-
A
---
W
K
E
E
E
G
A
L
V
I
S
-
N
L
---
P
--
E
R
F
T
L
K
I
I
N
E
I
S
P
A
A
N
T
A
L
E
G
L
Y
Q
S
G
D
A
L
C
T
Q
C
E
A
E
G
F
R
H
I
T
Y
Y
L
D
R
P
D
V
L
A
R
F
T
T
K
I
I
A
D
K
I
K
--
Y
P
F
L
L
S
N
G
N
R
V
A
Q
G
E
L
E
N
G
R
H
W
V
Q
W
Q
D
P
F
P
K
P
C
Y
L
F
A
L
V
A
G
D
F
D
V
L
R
D
T
F
T
T
R
-
S
G
R
E
V
A
L
E
L
Y
V
D
R
G
N
L
D
R
A
P
W
A
M
T
S
L
K
N
S
M
K
W
D
E
E
R
F
G
L
E
Y
D
L
D
I
Y
M
I
V
A
V
D
F
F
N
M
G
A
M
E
N
K
G
L
N
I
F
N
S
K
Y
V
L
A
R
T
D
T
A
T
D
K
D
Y
L
D
I
E
R
V
I
G
H
E
Y
F
H
N
W
T
G
N
R
V
T
C
R
D
W
F
Q
L
S
L
K
E
G
L
T
V
F
R
D
Q
E
F
S
S
D
L
G
S
R
A
V
N
R
I
N
N
V
R
T
M
R
G
L
Q
F
A
E
D
A
S
P
M
A
H
P
I
R
P
D
M
V
I
E
M
N
N
F
Y
T
L
T
V
Y
E
K
G
A
E
V
I
R
M
I
H
T
L
L
G
E
E
N
F
Q
K
G
M
Q
L
Y
F
E
R
H
D
G
S
A
A
T
C
D
D
F
V
Q
A
M
-------
E
D
A
S
N
-------
V
D
L
S
H
F
R
R
W
Y
S
Q
S
G
T
P
I
V
T
V
K
D
D
Y
N
P
E
T
E
Q
Y
T
L
T
I
S
Q
R
T
P
A
T
P
D
Q
A
E
K
Q
P
L
H
I
P
F
A
I
E
L
Y
D
N
-
E
-
G
K
V
I
P
L
Q
K
G
G
H
P
V
N
S
V
L
N
----
V
T
Q
A
E
Q
T
F
V
F
D
N
V
Y
F
Q
P
V
P
A
L
L
C
E
F
S
A
P
V
K
L
E
Y
K
W
S
D
Q
Q
L
T
F
L
M
R
H
A
R
N
D
F
S
R
W
D
A
A
------
Q
S
L
L
A
T
Y
I
K
L
N
V
A
R
H
Q
Q
G
Q
----------------------------
P
L
S
L
P
V
H
V
------------------
A
----------
D
A
------
F
R
A
V
L
---
L
D
E
K
I
D
--
P
A
---
L
A
A
E
I
L
T
L
--
P
S
V
N
E
M
A
E
L
F
D
I
-
I
D
P
I
A
I
A
E
V
R
E
A
L
T
R
T
L
A
T
E
L
A
----
D
E
L
L
A
I
Y
N
A
N
Y
------
Q
S
E
Y
---
R
V
E
H
E
D
I
A
K
R
T
L
R
N
A
C
L
R
F
L
A
F
G
E
T
H
L
A
D
V
L
V
S
K
Q
F
H
E
A
N
N
M
T
D
A
L
A
A
L
S
A
A
V
A
A
Q
L
P
C
R
D
A
L
M
Q
E
Y
D
D
K
W
H
Q
N
G
L
V
M
D
K
W
F
-
I
L
Q
A
T
S
P
A
A
-
N
-
V
L
E
T
V
R
G
L
L
Q
H
R
S
F
T
M
S
N
P
N
R
I
R
S
L
I
G
A
F
A
G
S
N
P
A
----
A
F
H
AED
G
S
G
Y
L
F
L
V
E
M
L
T
D
L
---
N
S
R
N
P
Q
V
A
S
R
L
I
E
P
L
I
R
L
K
R
Y
-
D
A
K
R
Q
E
K
M
R
A
A
L
E
Q
L
K
--------------------
19
PsiBlast_PDB
89.34
41%
15
- C3 -
-
5MFT
11
AMPN_ECOLI
A:
[24-873]
---------
Q
Q
P
Q
A
K
Y
R
H
D
Y
R
A
P
D
Y
Q
I
T
D
I
D
L
T
F
D
L
D
A
Q
K
T
V
V
T
A
V
S
Q
A
---
V
R
H
--
G
---
A
S
D
A
P
L
R
L
N
G
E
D
L
K
L
V
S
V
H
I
N
D
E
P
W
T
-
A
---
W
K
E
E
E
G
A
L
V
I
S
-
N
L
---
P
--
E
R
F
T
L
K
I
I
N
E
I
S
P
A
A
N
T
A
L
E
G
L
Y
Q
S
G
D
A
L
C
T
Q
C
E
A
E
G
F
R
H
I
T
Y
Y
L
D
R
P
D
V
L
A
R
F
T
T
K
I
I
A
D
K
I
K
--
Y
P
F
L
L
S
N
G
N
R
V
A
Q
G
E
L
E
N
G
R
H
W
V
Q
W
Q
D
P
F
P
K
P
C
Y
L
F
A
L
V
A
G
D
F
D
V
L
R
D
T
F
T
T
R
-
S
G
R
E
V
A
L
E
L
Y
V
D
R
G
N
L
D
R
A
P
W
A
M
T
S
L
K
N
S
M
K
W
D
E
E
R
F
G
L
E
Y
D
L
D
I
Y
M
I
V
A
V
D
F
F
N
M
G
A
M
E
N
K
G
L
N
I
F
N
S
K
Y
V
L
A
R
T
D
T
A
T
D
K
D
Y
L
D
I
E
R
V
I
G
H
E
Y
F
H
N
W
T
G
N
R
V
T
C
R
D
W
F
Q
L
S
L
K
E
G
L
T
V
F
R
D
Q
E
F
S
S
D
L
G
S
R
A
V
N
R
I
N
N
V
R
T
M
R
G
L
Q
F
A
E
D
A
S
P
M
A
H
P
I
R
P
D
M
V
I
E
M
N
N
F
Y
T
L
T
V
Y
E
K
G
A
E
V
I
R
M
I
H
T
L
L
G
E
E
N
F
Q
K
G
M
Q
L
Y
F
E
R
H
D
G
S
A
A
T
C
D
D
F
V
Q
A
M
-------
E
D
A
S
N
-------
V
D
L
S
H
F
R
R
W
Y
S
Q
S
G
T
P
I
V
T
V
K
D
D
Y
N
P
E
T
E
Q
Y
T
L
T
I
S
Q
R
T
P
A
T
P
D
Q
A
E
K
Q
P
L
H
I
P
F
A
I
E
L
Y
D
N
-
E
-
G
K
V
I
P
L
Q
K
G
G
H
P
V
N
S
V
L
N
----
V
T
Q
A
E
Q
T
F
V
F
D
N
V
Y
F
Q
P
V
P
A
L
L
C
E
F
S
A
P
V
K
L
E
Y
K
W
S
D
Q
Q
L
T
F
L
M
R
H
A
R
N
D
F
S
R
W
D
A
A
------
Q
S
L
L
A
T
Y
I
K
L
N
V
A
R
H
Q
Q
G
Q
----------------------------
P
L
S
L
P
V
H
V
------------------
A
----------
D
A
------
F
R
A
V
L
---
L
D
E
K
I
D
--
P
A
---
L
A
A
E
I
L
T
L
--
P
S
V
N
E
M
A
E
L
F
D
I
-
I
D
P
I
A
I
A
E
V
R
E
A
L
T
R
T
L
A
T
E
L
A
----
D
E
L
L
A
I
Y
N
A
N
Y
------
Q
S
E
Y
---
R
V
E
H
E
D
I
A
K
R
T
L
R
N
A
C
L
R
F
L
A
F
G
E
T
H
L
A
D
V
L
V
S
K
Q
F
H
E
A
N
N
M
T
D
A
L
A
A
L
S
A
A
V
A
A
Q
L
P
C
R
D
A
L
M
Q
E
Y
D
D
K
W
H
Q
N
G
L
V
M
D
K
W
F
-
I
L
Q
A
T
S
P
A
A
-
N
-
V
L
E
T
V
R
G
L
L
Q
H
R
S
F
T
M
S
N
P
N
R
I
R
S
L
I
G
A
F
A
G
S
N
P
A
----
A
F
H
AED
G
S
G
Y
L
F
L
V
E
M
L
T
D
L
---
N
S
R
N
P
Q
V
A
S
R
L
I
E
P
L
I
R
L
K
R
Y
-
D
A
K
R
Q
E
K
M
R
A
A
L
E
Q
L
K
--------------------
17
PsiBlast_PDB
89.29
41%
16
- C3 -
-
5MFR
12
AMPN_ECOLI
A:
[24-873]
---------
Q
Q
P
Q
A
K
Y
R
H
D
Y
R
A
P
D
Y
Q
I
T
D
I
D
L
T
F
D
L
D
A
Q
K
T
V
V
T
A
V
S
Q
A
---
V
R
H
--
G
---
A
S
D
A
P
L
R
L
N
G
E
D
L
K
L
V
S
V
H
I
N
D
E
P
W
T
-
A
---
W
K
E
E
E
G
A
L
V
I
S
-
N
L
---
P
--
E
R
F
T
L
K
I
I
N
E
I
S
P
A
A
N
T
A
L
E
G
L
Y
Q
S
G
D
A
L
C
T
Q
C
E
A
E
G
F
R
H
I
T
Y
Y
L
D
R
P
D
V
L
A
R
F
T
T
K
I
I
A
D
K
I
K
--
Y
P
F
L
L
S
N
G
N
R
V
A
Q
G
E
L
E
N
G
R
H
W
V
Q
W
Q
D
P
F
P
K
P
C
Y
L
F
A
L
V
A
G
D
F
D
V
L
R
D
T
F
T
T
R
-
S
G
R
E
V
A
L
E
L
Y
V
D
R
G
N
L
D
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A
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W
A
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L
K
N
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M
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L
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D
L
D
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Y
M
I
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A
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D
F
F
N
M
G
A
M
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N
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G
L
N
I
F
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Y
V
L
A
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A
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D
Y
L
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A
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N
F
Q
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Q
L
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F
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D
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S
A
A
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C
D
D
F
V
Q
A
M
-------
E
D
A
S
N
-------
V
D
L
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H
F
R
R
W
Y
S
Q
S
G
T
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I
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T
V
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D
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Y
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P
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Q
Y
T
L
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D
Q
A
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L
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-
E
-
G
K
V
I
P
L
Q
K
G
G
H
P
V
N
S
V
L
N
----
V
T
Q
A
E
Q
T
F
V
F
D
N
V
Y
F
Q
P
V
P
A
L
L
C
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A
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V
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L
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K
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D
Q
Q
L
T
F
L
M
R
H
A
R
N
D
F
S
R
W
D
A
A
------
Q
S
L
L
A
T
Y
I
K
L
N
V
A
R
H
Q
Q
G
Q
----------------------------
P
L
S
L
P
V
H
V
------------------
A
----------
D
A
------
F
R
A
V
L
---
L
D
E
K
I
D
--
P
A
---
L
A
A
E
I
L
T
L
--
P
S
V
N
E
M
A
E
L
F
D
I
-
I
D
P
I
A
I
A
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R
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A
L
T
R
T
L
A
T
E
L
A
----
D
E
L
L
A
I
Y
N
A
N
Y
------
Q
S
E
Y
---
R
V
E
H
E
D
I
A
K
R
T
L
R
N
A
C
L
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L
A
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V
L
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N
M
T
D
A
L
A
A
L
S
A
A
V
A
A
Q
L
P
C
R
D
A
L
M
Q
E
Y
D
D
K
W
H
Q
N
G
L
V
M
D
K
W
F
-
I
L
Q
A
T
S
P
A
A
-
N
-
V
L
E
T
V
R
G
L
L
Q
H
R
S
F
T
M
S
N
P
N
R
I
R
S
L
I
G
A
F
A
G
S
N
P
A
----
A
F
H
AED
G
S
G
Y
L
F
L
V
E
M
L
T
D
L
---
N
S
R
N
P
Q
V
A
S
R
L
I
E
P
L
I
R
L
K
R
Y
-
D
A
K
R
Q
E
K
M
R
A
A
L
E
Q
L
K
--------------------