@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMB8: (2017-11-07 )
MFDRPMLEFMKTLKIATRQSPLALWQAEHICARLQELHPDLTVELVKFVTQGDKILDTPLAKIGGKGLFVKELEAALLDGRADLAVHSMKDVPMALPEGLTLAVICEREDPLDAFVSNQFEKFADLPQGAKVGTSSLRRKSQILKQRPDLQIIDLRGNVGTRLAKLDDGQYDAIILASAGLKRLGLAERIRHCIEPSVSLPAVGQGALGLECRADDQEVLALIQPLLHPETDICVRAERAFNAYLEGGCQVPIAGYATLQDGKIHIEGRVGSVDGQTLLRAELTDEANNAQQLGENLARNLLDQGAGDLLKALY
Atome Classification :
(20 SA)
----.......-----..10.-------------.......20........30........-40---..------.......50........60........70........80........---90......--..100..----------.....110..-----------------------....-.120-.........130.......140...--------....150-..-.-....----------..160......-.170........---180...--..-.-.190------..------.....200-.........210.......220...------...-------.230.---------------......240.......250.......-260-........270...----....280-----------...------------------..--..-------------------------290.......300.......310..-------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----MFD
R
P
M
L
-----
E
F
M
K
T
-------------
L
K
I
ATRQS
P
L
A
L
W
Q
A
E
H
I
C
A
R
L
Q
E
LHP-
D
----
L
T
------
V
E
L
V
K
F
V
TQGDKILD
T
P
L
A
K
IGGKG
L
F
V
K
E
L
E
A
A
L
LDGRA
D
L
A
V
HSM---KDVPMALP--EG
L
T
L
A
V
----------
I
CERED
P
L
D
A
-----------------------
F
V
S
N
-
Q
F
---
E
K
F
ADLPQGAKV
G
T
S
S
L
R
R
K
S
Q
I
L
K
--------QRPD
L
---
Q
I
-
I
-
D
LRG----------NVG
T
R
L
A
KLDD-GQ-Y
D
A
I
I
L
ASA---
G
L
K
RL
G
--
L
A
-
E
-
R
I
R
H
------
C
I------EPSVSL---PAVGQGALG
L
E
CRA
D
D
Q
E
V
L
A
L
I
Q
P
------
L
LH-------PET
D
I
---------------
C
V
R
A
E
R
A
F
N
A
Y
LEGGCQVPIA
G
Y
A
T
L-Q-D-
G
K
I
H
I
EGRVGSVDG----
Q
T
L
L
R
A
E-----------LTD------------------EA--N
N
-------------------------
A
Q
Q
L
G
E
N
L
A
R
N
L
L
D
Q
G
A
G
D
L
L
K
A
LY-------------
5
PsiBlast_PDB
94.17
60%
-85
- C3 -
-
1AH5
-
HEM3_ECOLI
A:
[4-307]
-------------------
N
V
-------------
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
-
G
----
L
V
------
V
E
L
V
P
M
V
T
R
G
D
------------
K
G
L
F
V
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
---
K
D
V
P
V
E
F
P
--
Q
G
L
G
L
V
T
----------
I
C
E
R
E
D
P
R
D
A
-----------------------
F
V
S
N
-
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
Q
C
Q
L
A
E
--------
R
R
P
D
L
---
I
I
-
R
-
S
L
R
G
----------
N
V
G
T
R
L
S
K
L
D
N
-
G
E
-
Y
D
A
I
I
L
A
V
A
---
G
L
K
R
L
G
--
L
E
-
S
-
R
I
R
A
------
A
L
------
P
P
E
I
S
L
---
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
------
L
N
H
-------
H
E
T
A
L
---------------
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
-
I
-
D
-
G
E
I
W
L
R
A
L
V
G
A
P
D
G
----
S
Q
I
I
R
G
E
-----------
R
R
G
------------------
A
P
--
Q
D
-------------------------
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
Y
-------------
2
PsiBlast_PDB
93.63
60%
-92
- C3 -
-
1GTK
-
HEM3_ECOLI
A:
[4-307]
-------------------
N
V
-------------
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
-
G
----
L
V
------
V
E
L
V
P
M
V
-----------------
G
L
F
V
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
---
K
D
V
P
V
E
F
P
--
Q
G
L
G
L
V
T
----------
I
C
E
R
E
D
P
R
D
A
-----------------------
F
V
S
N
-
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
Q
C
Q
L
A
E
--------
R
R
P
D
L
---
I
I
-
R
-
S
L
R
G
----------
N
V
G
T
R
L
S
K
L
D
N
-
G
E
-
Y
D
A
I
I
L
A
V
A
---
G
L
K
R
L
G
--
L
E
-
S
-
R
I
R
A
------
A
L
------
P
P
E
I
S
L
---
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
------
L
N
H
-------
H
E
T
A
L
---------------
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
-
I
-
D
-
G
E
I
W
L
R
A
L
V
G
A
P
D
G
----
S
Q
I
I
R
G
E
-----------
R
R
G
------------------
A
P
--
Q
D
-------------------------
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
Y
-------------
3
PsiBlast_PDB
93.58
60%
-82
- C3 -
-
1PDA
1
HEM3_ECOLI
A:
[4-307]
-------------------
N
V
-------------
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
-
G
----
L
V
------
V
E
L
V
P
M
V
T
R
G
D
V
I
---------
G
K
G
L
F
V
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
---
K
D
V
P
V
E
F
P
--
Q
G
L
G
L
V
T
----------
I
C
E
R
E
D
P
R
D
A
-----------------------
F
V
S
N
-
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
Q
C
Q
L
A
E
--------
R
R
P
D
L
---
I
I
-
R
-
S
L
R
G
----------
N
V
G
T
R
L
S
K
L
D
N
-
G
E
-
Y
D
A
I
I
L
A
V
A
---
G
L
K
R
L
G
--
L
E
-
S
-
R
I
R
A
------
A
L
------
P
P
E
I
S
L
---
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
------
L
N
H
-------
H
E
T
A
L
---------------
R
V
T
A
E
R
A
M
N
T
R
L
E
G
A
C
Q
V
P
I
G
S
Y
A
E
L
-
I
-
D
-
G
E
I
W
L
R
G
L
V
G
A
P
D
G
----
S
Q
I
I
R
G
E
-----------
R
R
G
------------------
A
P
--
Q
D
-------------------------
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
Y
-------------
4
PsiBlast_PDB
93.55
60%
-85
- C3 -
-
1YPN
-
HEM3_ECOLI
A:
[4-306]
-------------------
N
V
-------------
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
-
G
----
L
V
------
V
E
L
V
P
M
V
T
R
G
D
V
----------
G
Q
G
L
F
V
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
---
K
D
V
P
V
E
F
P
--
Q
G
L
G
L
V
T
----------
I
C
E
R
E
D
P
R
D
A
-----------------------
F
V
S
N
-
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
Q
C
Q
L
A
E
--------
R
R
P
D
L
---
I
I
-
R
-
S
L
R
G
----------
N
V
G
T
R
L
S
K
L
D
N
-
G
E
-
Y
D
A
I
I
L
A
V
A
---
G
L
K
R
L
G
--
L
E
-
S
-
R
I
R
A
------
A
L
------
P
P
E
I
S
L
---
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
------
L
N
H
-------
H
E
T
A
L
---------------
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
-
I
-
D
-
G
E
I
W
L
R
A
L
V
G
A
P
D
G
----
S
Q
I
I
R
G
E
-----------
R
R
G
------------------
A
P
--
Q
D
-------------------------
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
--------------
1
PsiBlast_PDB
93.03
60%
-93
- C3 -
-
2YPN
-
HEM3_ECOLI
A:
[4-307]
-------------------
N
V
-------------
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
-
G
----
L
V
------
V
E
L
V
P
M
V
-----------------
G
L
F
V
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
---
K
D
V
P
V
E
F
P
--
Q
G
L
G
L
V
T
----------
I
C
E
R
E
D
P
R
D
A
-----------------------
F
V
S
N
-
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
Q
C
Q
L
A
E
--------
R
R
P
D
L
---
I
I
-
R
-
S
L
R
G
----------
N
V
G
T
R
L
S
K
L
D
N
-
G
E
-
Y
D
A
I
I
L
A
V
A
---
G
L
K
R
L
G
--
L
E
-
S
-
R
I
R
A
------
A
L
------
P
P
E
I
S
L
---
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
------
L
N
H
-------
H
E
T
A
L
---------------
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
-
I
-
D
-
G
E
I
W
L
R
A
L
V
G
A
P
D
G
----
S
Q
I
I
R
G
E
-----------
R
R
G
------------------
A
P
--
Q
D
-------------------------
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
Y
-------------
25
HHSearch
84.84
59%
-2
- C3 -
-
1AH5
-
HEM3_ECOLI
A:
[3-307]
------------------
D
N
V
-------------
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
-
H
P
G
----
L
V
------
V
E
L
V
P
M
V
T
R
G
D
------------
K
G
L
F
V
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
---
K
D
V
P
V
E
F
P
--
Q
G
L
G
L
V
T
----------
I
C
E
R
E
D
P
R
D
A
-----------------------
F
V
S
N
-
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
Q
C
Q
L
A
E
--------
R
R
P
D
L
---
I
I
-
R
-
S
L
R
G
----------
N
V
G
T
R
L
S
K
L
D
N
-
G
E
-
Y
D
A
I
I
L
A
V
A
---
G
L
K
R
L
G
--
L
E
-
S
-
R
I
R
A
------
A
L
------
P
P
E
I
S
L
---
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
------
L
N
H
-------
H
E
T
A
L
---------------
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
-
I
-
D
-
G
E
I
W
L
R
A
L
V
G
A
P
D
G
----
S
Q
I
I
R
G
E
-----------
R
R
G
------------------
A
P
--
Q
D
-------------------------
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
Y
-------------
24
HHSearch
84.42
59%
-11
- C3 -
-
1GTK
-
HEM3_ECOLI
A:
[3-307]
------------------
D
N
V
-------------
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
-
H
P
G
----
L
V
------
V
E
L
V
P
M
V
-----------------
G
L
F
V
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
---
K
D
V
P
V
E
F
P
--
Q
G
L
G
L
V
T
----------
I
C
E
R
E
D
P
R
D
A
-----------------------
F
V
S
N
-
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
Q
C
Q
L
A
E
--------
R
R
P
D
L
---
I
I
-
R
-
S
L
R
G
----------
N
V
G
T
R
L
S
K
L
D
N
-
G
E
-
Y
D
A
I
I
L
A
V
A
---
G
L
K
R
L
G
--
L
E
-
S
-
R
I
R
A
------
A
L
------
P
P
E
I
S
L
---
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
------
L
N
H
-------
H
E
T
A
L
---------------
R
V
T
A
E
R
A
M
N
T
R
L
E
G
G
C
Q
V
P
I
G
S
Y
A
E
L
-
I
-
D
-
G
E
I
W
L
R
A
L
V
G
A
P
D
G
----
S
Q
I
I
R
G
E
-----------
R
R
G
------------------
A
P
--
Q
D
-------------------------
A
E
Q
M
G
I
S
L
A
E
E
L
L
N
N
G
A
R
E
I
L
A
E
V
Y
-------------
6
PsiBlast_PDB
78.48
48%
-46
- C3 -
-
4MLQ
2
?
A:
[3-299]
------------------
M
R
K
-------------
I
I
V
G
S
R
R
S
K
L
A
L
T
Q
T
K
W
V
I
E
Q
L
K
K
Q
G
L
-
P
----
F
E
------
F
E
I
K
E
M
V
---------------------
K
E
I
E
Q
A
M
L
D
K
E
I
D
M
A
V
H
S
M
---
K
D
M
P
A
V
L
P
--
E
G
L
T
I
G
C
----------
I
P
L
R
E
D
H
R
D
A
-----------------------
L
I
S
K
-
N
G
---
E
R
F
E
E
L
P
S
G
A
V
I
G
T
S
S
L
R
R
G
A
Q
L
L
S
--------
M
R
S
D
I
---
E
I
-
K
-
W
I
R
G
----------
N
I
D
T
R
L
E
K
L
K
N
-
E
D
-
Y
D
A
I
I
L
A
A
A
---
G
L
S
R
M
G
--
W
S
K
D
-
T
V
T
Q
------
Y
L
------
E
P
E
I
S
V
---
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
------
L
N
H
-------
D
E
T
A
R
---------------
A
V
R
A
E
R
V
F
L
K
E
M
E
G
G
C
Q
V
P
I
A
G
Y
G
R
I
-
L
-
D
G
G
N
I
E
L
T
S
L
V
A
S
P
D
G
----
K
T
I
Y
K
E
H
-----------
I
T
--------------------
G
--
K
D
-------------------------
P
I
A
I
G
S
E
A
A
E
R
L
T
S
Q
G
A
---------------------
7
PsiBlast_PDB
77.86
48%
-44
- C3 -
-
4MLV
2
?
A:
[3-299]
------------------
M
R
K
-------------
I
I
V
G
S
R
R
S
K
L
A
L
T
Q
T
K
W
V
I
E
Q
L
K
K
Q
G
L
-
P
----
F
E
------
F
E
I
K
E
M
V
---------------------
K
E
I
E
Q
A
M
L
D
K
E
I
D
M
A
V
H
S
M
---
K
D
M
P
A
V
L
P
--
E
G
L
T
I
G
C
----------
I
P
L
R
E
D
H
R
D
A
-----------------------
L
I
S
K
-
N
G
---
E
R
F
E
E
L
P
S
G
A
V
I
G
T
S
S
L
R
R
G
A
Q
L
L
S
--------
M
R
S
D
I
---
E
I
-
K
-
W
I
R
G
----------
N
I
D
T
R
L
E
K
L
K
N
-
E
D
-
Y
D
A
I
I
L
A
A
A
---
G
L
S
R
M
G
--
W
S
K
D
-
T
V
T
Q
------
Y
L
------
E
P
E
I
S
V
---
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
------
L
N
H
-------
D
E
T
A
R
---------------
A
V
R
A
E
R
V
F
L
K
E
M
E
G
G
C
Q
V
P
I
A
G
Y
G
R
I
-
L
-
D
G
G
N
I
E
L
T
S
L
V
A
S
P
D
G
----
K
T
I
Y
K
E
H
-----------
I
T
--------------------
G
--
K
D
-------------------------
P
I
A
I
G
S
E
A
A
E
R
L
T
S
Q
G
A
---------------------
8
PsiBlast_PDB
77.43
42%
-16
- C3 -
-
3ECR
-
HEM3_HUMAN
A:
[21-354]
------------------
M
R
V
-------------
I
R
V
G
T
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
-
G
----
L
Q
------
F
E
I
I
A
M
-------------------
L
F
T
K
E
L
E
H
A
L
E
K
N
E
V
D
L
V
V
H
S
L
---
K
D
L
P
T
V
L
P
--
P
G
F
T
I
G
A
----------
I
C
K
R
E
N
P
H
D
A
-----------------------
V
V
F
H
P
K
F
VG-
K
T
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
R
R
A
A
Q
L
Q
R
--------
K
F
P
H
L
---
E
F
-
R
-
S
I
R
G
----------
N
L
N
T
R
L
R
K
L
D
E
-
Q
Q
E
F
S
A
I
I
L
A
T
A
---
G
L
Q
R
M
G
--
W
H
-
N
-
R
V
G
Q
------
I
L
------
H
P
E
E
C
M
---
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
------
L
H
D
-------
P
E
T
L
L
---------------
R
C
I
A
E
R
A
F
L
R
H
L
E
--
C
S
V
P
V
A
V
H
T
A
M
-
K
-
D
-
G
Q
L
Y
L
T
G
G
V
W
S
L
D
G
S
D
S
I
Q
E
T
M
Q
A
T
-----------
I
H
V
------------------
P
A
--
Q
H
EDGPEDDPQLVGITARNIP
R
G
P
Q
L
A
A
Q
N
L
G
I
S
L
A
N
L
L
L
S
K
G
A
K
N
I
L
-----------------
14
Fugue
76.02
64%
-86
- C3 -
-
1PDA
1
?
?:
[3-219]
------------------
D
N
V
-------------
L
R
I
A
T
R
Q
S
P
L
A
L
W
Q
A
H
Y
V
K
D
K
L
M
A
S
H
P
-
G
----
L
V
------
V
E
L
V
P
M
V
T
R
G
D
V
---------
I
G
K
G
L
F
V
K
E
L
E
V
A
L
L
E
N
R
A
D
I
A
V
H
S
M
---
K
D
V
P
V
E
F
P
--
Q
G
L
G
L
V
T
----------
I
C
E
R
E
D
P
R
D
A
-----------------------
F
V
S
N
-
N
Y
---
D
S
L
D
A
L
P
A
G
S
I
V
G
T
S
S
L
R
R
Q
C
Q
L
A
E
--------
R
R
P
D
L
---
I
I
-
R
-
S
L
R
G
----------
N
V
G
T
R
L
S
K
L
D
N
-
G
E
-
Y
D
A
I
I
L
A
V
A
---
G
L
K
R
L
G
--
L
E
-
S
-
R
I
R
A
------
A
L
------
P
P
E
I
S
L
---
P
A
V
G
Q
G
A
V
G
I
E
C
R
L
D
D
S
R
T
R
E
L
L
A
A
------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.34
42%
-5
- C3 -
-
3EQ1
-
HEM3_HUMAN
A:
[19-351]
-------------------
R
V
-------------
I
R
V
G
T
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
Y
P
-
G
----
L
Q
------
F
E
I
I
A
---------------------
F
T
K
E
L
E
H
A
L
E
K
N
E
V
D
L
V
V
H
S
L
---
K
D
L
P
T
V
L
P
--
P
G
F
T
I
G
A
----------
I
C
K
R
E
N
P
H
D
A
-----------------------
V
V
F
H
P
K
F
VG-
K
T
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
R
R
A
A
Q
L
Q
R
--------
K
F
P
H
L
---
E
F
-
R
-
S
I
Q
G
----------
N
L
N
T
R
L
R
K
L
D
E
-
Q
Q
E
F
S
A
I
I
L
A
T
A
---
G
L
Q
R
M
G
--
W
H
-
N
-
R
V
G
Q
------
I
L
------
H
P
E
E
C
M
---
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
------
L
H
D
-------
P
E
T
L
L
---------------
R
C
I
A
E
R
A
F
L
R
H
L
E
G
G
C
S
V
P
V
A
V
H
T
A
M
-
K
-
D
-
G
Q
L
Y
L
T
G
G
V
W
S
L
D
G
S
D
S
I
Q
E
T
M
Q
A
T
-----------
I
H
V
------------------
P
---
Q
H
ED
D
P
Q
L
VGITARNIPR
G
P
Q
L
A
----
A
Q
N
L
G
I
S
L
A
N
L
L
L
S
K
G
A
K
N
I
L
-----------------
27
HHSearch
74.69
44%
15
- C3 -
-
3ECR
-
HEM3_HUMAN
A:
[21-358]
------------------
M
R
V
-------------
I
R
V
G
T
R
K
S
Q
L
A
R
I
Q
T
D
S
V
V
A
T
L
K
A
S
-
Y
P
G
----
L
Q
------
F
E
I
I
A
M
-------------------
L
F
T
K
E
L
E
H
A
L
E
K
N
E
V
D
L
V
V
H
S
L
---
K
D
L
P
T
V
L
P
--
P
G
F
T
I
G
A
----------
I
C
K
R
E
N
P
H
D
A
-----------------------
V
V
F
H
-
P
K
FVG
K
T
L
E
T
L
P
E
K
S
V
V
G
T
S
S
L
R
R
A
A
Q
L
Q
R
--------
K
F
P
H
L
---
E
F
-
R
-
S
I
R
G
----------
N
L
N
T
R
L
R
K
L
D
E
Q
Q
E
-
F
S
A
I
I
L
A
T
A
---
G
L
Q
R
M
G
--
W
H
-
N
-
R
V
G
Q
------
I
L
------
H
P
E
E
C
M
---
Y
A
V
G
Q
G
A
L
G
V
E
V
R
A
K
D
Q
D
I
L
D
L
V
G
V
------
L
H
D
-------
P
E
T
L
L
---------------
R
C
I
A
E
R
A
F
L
R
H
L
E
--
C
S
V
P
V
A
V
H
T
A
M
-
K
-
D
-
G
Q
L
Y
L
T
G
G
V
W
S
L
D
G
----
S
D
S
I
Q
E
T
M
Q
A
T
I
H
VPAQH
E
D
G
PEDDPQLVGITARNIP
R
G
P
Q
--
L
A
-------------------------
A
Q
N
L
G
I
S
L
A
N
L
L
L
S
K
G
A
K
N
I
L
D
V
A
R
-------------
26
HHSearch
73.55
48%
13
- C3 -
-
4MLV
2
?
A:
[1-307]
----------------
S
H
M
R
K
-------------
I
I
V
G
S
R
R
S
K
L
A
L
T
Q
T
K
W
V
I
E
Q
L
K
K
Q
-
G
L
P
----
F
E
------
F
E
I
K
E
M
V
---------------------
K
E
I
E
Q
A
M
L
D
K
E
I
D
M
A
V
H
S
M
---
K
D
M
P
A
V
L
P
--
E
G
L
T
I
G
C
----------
I
P
L
R
E
D
H
R
D
A
-----------------------
L
I
S
K
-
N
G
---
E
R
F
E
E
L
P
S
G
A
V
I
G
T
S
S
L
R
R
G
A
Q
L
L
S
--------
M
R
S
D
I
---
E
I
-
K
-
W
I
R
G
----------
N
I
D
T
R
L
E
K
L
K
N
-
E
D
-
Y
D
A
I
I
L
A
A
A
---
G
L
S
R
M
G
--
W
S
-
K
D
T
V
T
Q
------
Y
L
------
E
P
E
I
S
V
---
P
A
V
G
Q
G
A
L
A
I
E
C
R
E
N
D
H
E
L
L
S
L
L
Q
A
------
L
N
H
-------
D
E
T
A
R
---------------
A
V
R
A
E
R
V
F
L
K
E
M
E
G
G
C
Q
V
P
I
A
G
Y
G
R
I
-
L
D
G
-
G
N
I
E
L
T
S
L
V
A
S
P
D
G
----
K
T
I
Y
K
E
H
-----------
I
T
G
----------------------
K
D
-------------------------
P
I
A
I
G
S
E
A
A
E
R
L
T
S
Q
G
A
K
L
L
I
D
R
V
K
-------------
28
HHSearch
69.07
43%
33
* C3 *
-
4HTG
1
HEM3_ARATH
A:
[10-311]
------------------
T
A
I
-------------
I
R
I
G
T
R
G
S
P
L
A
L
A
Q
A
Y
E
T
R
E
K
L
K
K
K
H
P
-
E
LVED
G
A
------
I
H
I
E
I
I
K
T
T
G
D
K
I
L
S
Q
P
L
A
D
I
G
G
K
G
L
F
T
K
E
I
D
E
A
L
I
N
G
H
I
D
I
A
V
H
S
M
---
K
D
V
P
T
Y
L
P
--
E
K
T
I
L
P
C
----------
N
L
P
R
E
D
V
R
D
A
-----------------------
F
I
C
L
-
T
A
---
A
T
L
A
E
L
P
A
G
S
V
V
G
T
A
S
L
R
R
K
S
Q
I
L
H
--------
K
Y
P
A
L
---
H
V
-
E
E
N
F
R
G
----------
N
V
Q
T
R
L
S
K
L
Q
G
-
G
K
-
V
Q
A
T
L
L
A
L
A
---
G
L
K
R
L
S
--
M
T
-
E
-
N
V
A
S
------
I
L
------
S
L
D
E
M
L
---
P
A
V
A
Q
G
A
I
G
I
A
C
R
T
D
D
D
K
M
A
T
Y
L
A
S
------
L
N
H
-------
E
E
T
R
L
---------------
A
I
S
C
E
R
A
F
L
E
T
L
D
G
S
C
R
T
P
I
A
G
Y
A
S
K
-
D
E
E
-
G
N
C
I
F
R
G
L
V
A
S
P
D
G
----
T
K
V
L
E
T
S
-----------
R
K
G
------------------
P
Y
V
Y
E
D
-------------------------
M
V
K
M
G
K
D
A
G
Q
E
L
L
S
------------------------
10
PsiBlast_PDB
65.89
47%
37
- C3 -
-
4HTG
1
HEM3_ARATH
A:
[13-285]
----------------------------------
I
R
I
G
T
R
G
S
P
L
A
L
A
Q
A
Y
E
T
R
E
K
L
K
K
K
H
P
-
E
----
L
V
EDGA
I
H
I
E
I
I
K
--
T
T
G
D
K
I
L
S
Q
P
L
A
D
I
G
G
K
G
L
F
T
K
E
I
D
E
A
L
I
N
G
H
I
D
I
A
V
H
S
M
---
K
D
V
P
T
Y
L
P
--
E
K
T
I
L
P
C
----------
N
L
P
R
E
D
V
R
D
A
-----------------------
F
I
C
L
-
T
A
---
A
T
L
A
E
L
P
A
G
S
V
V
G
T
A
S
L
R
R
K
S
Q
I
L
H
--------
K
Y
P
A
L
---
H
V
E
E
-
N
F
R
G
----------
N
V
Q
T
R
L
S
K
L
Q
G
-
G
K
-
V
Q
A
T
L
L
A
L
A
---
G
L
K
R
L
S
--
M
T
-
E
-
N
V
A
S
------
I
L
------
S
L
D
E
M
L
---
P
A
V
A
Q
G
A
I
G
I
A
C
R
T
D
D
D
K
M
A
T
Y
L
A
S
------
L
N
H
-------
E
E
T
R
L
---------------
A
I
S
C
E
R
A
F
L
E
T
L
D
G
S
C
R
T
P
I
A
G
Y
A
S
K
D
E
-
E
-
G
N
C
I
F
R
G
L
V
A
S
P
D
G
----
T
K
V
L
--------------------------------------------------------------------------------------------------------
19
Fugue
31.10
22%
24
- C2 -
-
5F4H
5
?
A:
[1-437]
M
N
D
L
M
L
D
K
S
A
L
L
F
G
V
S
K
Y
L
E
K
GIIT
G
N
V
L
I
H
K
S
L
L
A
E
L
E
R
E
S
N
D
G
L
V
S
A
E
I
A
L
D
E
V
K
K
L
K
D
-
I
----
T
E
------
R
I
L
V
N
F
E
I
V
G
D
D
S
K
K
G
E
A
N
E
L
S
R
E
Y
C
L
E
K
G
C
I
I
V
T
A
D
E
T
Q
K
K
I
C
D
A
M
G
I
Q
Y
N
F
L
Q
P
L
K
--
Q
G
L
S
F
E
S
FFDDETM
S
L
H
I
K
E
D
T
V
P
R
A
K
K
G
K
P
G
N
W
K
F
V
N
LSD
K
P
M
L
S
T
D
V
R
M
I
A
N
-
E
I
---
I
N
A
V
R
L
I
K
G
S
F
V
E
I
E
--
R
R
G
S
L
I
I
Q
L
GN
Y
R
V
V
I
T
R
P
P
L
SD
G
W
E
-
I
-
T
I
T
R
P
V
VRKRLEDY
N
L
D
E
R
L
I
K
R
L
E
-
E
R
-
A
E
G
I
I
I
A
G
A
PGM
G
A
T
T
F
A
Q
A
L
A
-
E
-
Y
Y
M
R
L
G
K
I
V
K
T
I
------
E
S
P
R
D
M
H
L
P
P
E
I
T
Q
Y
S
K
N
Y
A
E
I
G
E
L
H
D
I
L
L
L
S
R
P
D
Y
T
V
Y
D
E
M
R
-------
N
D
E
D
F
K
L
Y
V
D
L
R
L
A
G
V
G
M
V
G
V
V
H
A
T
S
P
I
D
A
I
H
R
F
V
N
R
V
D
I
G
T
I
P
N
I
-
L
-
D
-
T
I
I
F
I
N
S
--
G
N
V
S
K
----
V
Y
T
L
E
M
T
-----------
V
K
V
------------------
P
A
--
G
L
-------------------------
K
E
A
D
L
A
R
P
V
V
E
I
K
D
L
A
T
G
N
T
E
Y
E
I
Y
V
FGEQ
T
M
I
V
P
VNR
31
HHSearch
30.09
14%
-20
- C3 -
-
3IR1
-
?
F:
[41-107]
--------------------------------------------------------------------------------------------------------
R
P
N
L
A
L
A
E
G
E
L
D
I
N
V
F
Q
H
---
K
P
Y
L
D
D
F
K
KE
H
N
L
D
I
T
E
----------
V
F
Q
V
P
T
A
P
L
G
-----------------------
L
Y
P
G
-
K
L
---
K
S
L
E
E
V
K
D
G
S
T
V
S
A
P
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
28.86
30%
-132
- C3 -
-
2Q74
-
SUHB_MYCTU
A:
[144-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
S
A
A
T
---
G
L
G
A
H
L
--
T
D
-
E
-
R
G
R
H
------
V
L
R
C
T
GVD
E
L
S
M
A
L
---
L
G
T
G
F
G
-
Y
S
V
R
C
R
E
K
Q
A
E
L
L
A
H
V
V
P
------
L
V
R
D
V
R
R
I
GS
A
A
L
D
L
---------------
C
M
V
A
A
G
R
L
D
A
Y
Y
E
H
G
V
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
28.53
13%
-21
- C- -
-
3DEL
-
ARTJ_CHLTR
D:
[84-192]
--------------------------------------------------------------------------------------------------------
A
L
I
L
N
L
K
Q
H
R
I
D
A
V
I
T
G
M
---
S
I
T
P
S
R
-
L
--
K
E
I
L
M
I
P
----------
Y
Y
G
-
E
E
I
K
H
L
-----------------------
V
L
V
F
-
K
G
ENK
H
P
L
P
L
T
-
Q
Y
R
S
V
A
V
Q
T
G
T
Y
Q
E
A
Y
L
Q
--------
S
L
S
E
V
---
H
I
-
R
-
S
F
-
D
----------
S
T
L
E
V
L
M
E
V
M
H
-
G
K
-
S
P
V
A
V
L
E
P
S
---
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------