@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMD7: (2017-11-07 )
MNQLTNLSSAEISAQHEQDAKDLTRILPASKKVYIEGSRPDIQVPMREISLTDTPTGLGGEHNPPIMVYDTSGVYTDPNVQIDLNKGLPSVRQKWIEERNDTDVLSGLTSKFGQERLKDIRTADIRFAHIQNPRRAKAGKNVTQMHYAKQGIITPEMEYIAIRENQRQHEAVDMRQHPGQNFGAKNLKEITPEFVRQEVAEGRAIIPANINHPELEPMIIGRNFLVKINANIGNSALGSSIDEEVAKMTWATRWGADTIMDLSTGKNIHETREWIIRNSPVPIGTVPIYQALEKVDGVAENLTWEIFKDTLIEQAEQGVDYFTIHAGVLLRYVPLTANRLTGIVSRGGSIMAQWCLAHHEENFLYTHFDEICEIMKAYDVSFSLGDGLRPGCIQDANDEAQFSELKTLGELTHRAWERDVQVMIEGPGHVPMHMIKENMDLQLEVCKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAMLCYVTPKEHLGLPNKKDVKDGIITYKIAAHAADLAKGHPGAQARDNALSKARFEFRWDDQFNLSLDPDTARSMHDETLPKEAHKSAHFCSMCGPKFCSMKITQNVRDYANNLTNSDSEVEEGLKAMKEVYQEQGQKLYHKV
Atome Classification :
(20 SA)
.........10........20........30.......----.-40........50........60........70........80........90........100...-....110.......120......---.-130------.........140.......150.......160...-....170.......180.......190.......200.......210.......220.......230..-.....240.......250.......260.......270.......280.......290.......300.....--..310.......320.....--..330.......-------------340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540....---...550.......560.......570.......580.......590.--.....--.600.......610.......620...-------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNQLTNLSSAEI
S
A
Q
H
E
Q
D
A
K
D
L
T
R
ILPAS
K
K
V
Y
I
EGS----R-P
D
I
Q
V
P
M
R
E
I
SLTDTPTGLGGEHNP
P
I
M
V
Y
DTSGVYTDP
N
V
Q
I
D
LNKG
L
P
S
V
R
Q
K
W
I
E
ERN
D
T
D
V
L
-
S
G
L
T
S
K
F
G
Q
E
R
L
K
DIRTAD
I
R
F
A
---H-I--------QNPRRAKAGKN
V
T
Q
M
H
Y
AKQGIITPE
M
E
Y
I
A
IREN-Q
R
Q
H
E
A
V
D
M
R
QHPGQNF
G
A
K
N
L
K
E
I
T
P
E
F
V
R
Q
E
V
AEG
R
A
I
I
PANINHPEL
E
P
M
I
IG
R
N
F
L
V
K
I
NANIGN-SALG
S
S
I
D
E
E
V
A
K
M
T
W
ATRWGA
D
T
I
M
DLSTGK
N
I
H
E
T
R
E
W
I
IRNSPVPI
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
V
A
E
N
L
T
W
E
I
F
--
K
D
T
L
I
E
Q
A
E
QGV
D
Y
F
T
I
H
A
G
--
V
L
L
R
YVPL
T
A
N
R
-------------
L
T
G
I
V
SR
G
G
S
I
M
A
Q
W
C
L
A
H
HEEN
F
L
Y
T
H
F
D
E
I
C
E
I
M
K
A
YD
V
S
F
SLGDGLRPGCIQDAN
D
E
A
Q
F
S
E
L
K
T
L
G
E
L
T
H
R
A
W
E
R
D
V
Q
V
M
I
EGPGHV
P
M
H
M
I
K
ENM
D
L
Q
L
E
V
CKEAP
F
Y
TLGPLTTDIAP
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
WYG
T
A
M
L
C
Y
V
T
P
K
E
HLGLP
N
K
K
D
VKD
G
I
I
T
Y
K
I
A
A
H
A
A
D
L
AKGHPGA
Q
A
R
DNALSK
A
R
F
E
F
RWDDQFN---LSLDPD
T
A
RS
M
H
DETL
P
K
E
A
HKSA
H
F
C
S
MCGPKFC
S
M
K
I
T
Q
N
V
R
D
Y
A
--NNLTN--
S
D
S
E
V
E
E
G
L
K
A
M
K
E
V
Y
Q
E
Q
G
Q
K
L
YHKV-------
24
HHSearch
71.56
67%
18
- C2 -
-
4S2A
1
THIC_CAUCR
A:
[17-612]
----------------------
S
T
G
P
I
P
G
S
R
K
V
Y
Q
A
G
E
----
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
------
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
G
D
V
E
E
V
A
D
P
R
Q
V
K
P
E
D
N
G
F
A
Q
G
K
H
L
A
P
E
F
P
---
D
T
G
--------
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
-
L
R
R
E
Q
D
R
P
-
C
V
R
D
G
E
D
F
G
A
S
I
P
D
F
V
T
P
E
F
V
R
Q
E
I
A
R
G
R
A
I
I
P
A
N
I
N
H
G
E
L
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
-----
S
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
--
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
R
L
P
F
I
P
M
T
A
K
R
-------------
V
T
G
I
V
S
R
G
G
S
I
M
A
K
W
C
L
A
H
H
K
E
N
F
L
Y
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
G
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
E
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
Q
V
M
I
E
G
P
G
H
V
A
M
H
K
I
K
A
N
M
D
E
Q
L
K
H
C
H
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
A
R
F
E
F
R
W
E
D
Q
F
N
---
L
G
L
D
P
E
T
A
R
K
F
H
D
E
T
L
P
K
E
A
H
K
T
A
H
F
C
S
M
C
G
P
K
F
C
S
M
K
I
S
Q
E
V
R
D
F
A
--
A
G
K
----
A
P
N
S
A
E
L
G
M
A
E
M
S
E
K
F
R
E
Q
G
S
E
I
Y
L
K
--------
8
PsiBlast_PDB
70.98
62%
-51
- C2 -
-
4S27
5
THIC_ARATH
A:
[32-523]
------------------------------
K
E
V
V
H
E
E
S
----
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
------
G
G
E
--
P
A
F
D
N
Y
D
T
S
G
----
P
Q
-
N
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
E
-----------
K
L
G
T
P
R
Y
-------------------------------------
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-------------------------
K
L
D
P
E
F
V
R
S
E
V
A
R
G
R
A
I
I
P
S
N
K
K
H
L
E
L
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
-
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
--
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
L
L
R
Y
I
P
L
T
A
K
R
-------------
L
T
G
I
V
S
R
G
G
S
I
H
A
K
W
C
L
A
Y
H
K
E
N
F
A
Y
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
G
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
E
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
Q
V
M
N
E
G
P
G
H
V
P
M
H
K
I
P
E
N
M
Q
K
Q
L
E
W
C
N
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
A
R
F
E
F
R
W
M
D
Q
F
A
---
L
S
L
D
P
M
T
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E------------------------------------------
9
PsiBlast_PDB
70.71
62%
-51
- C2 -
-
4S28
5
THIC_ARATH
A:
[32-530]
------------------------------
K
E
V
V
H
E
E
S
----
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
------
G
G
E
--
P
A
F
D
N
Y
D
T
S
G
----
P
Q
-
N
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
E
-----------
K
L
G
T
P
R
Y
-------------------------------------
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-------------------------
K
L
D
P
E
F
V
R
S
E
V
A
R
G
R
A
I
I
P
S
N
K
K
H
L
E
L
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
-
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
--
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
L
L
R
Y
I
P
L
T
A
K
R
-------------
L
T
G
I
V
S
R
G
G
S
I
H
A
K
W
C
L
A
Y
H
K
E
N
F
A
Y
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
G
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
E
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
Q
V
M
N
E
G
P
G
H
V
P
M
H
K
I
P
E
N
M
Q
K
Q
L
E
W
C
N
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
A
R
F
E
F
R
W
M
D
Q
F
A
---
L
S
L
D
P
M
T
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
EE
N
G
Y
G
S
--
A
---------------------------------
6
PsiBlast_PDB
70.13
62%
-50
- C2 -
-
4S25
5
THIC_ARATH
A:
[32-523]
------------------------------
K
E
V
V
H
E
E
S
----
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
------
G
G
E
--
P
A
F
D
N
Y
D
T
S
G
----
P
Q
-
N
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
E
-----------
K
L
G
T
P
R
Y
-------------------------------------
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-------------------------
K
L
D
P
E
F
V
R
S
E
V
A
R
G
R
A
I
I
P
S
N
K
K
H
L
E
L
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
-
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
--
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
L
L
R
Y
I
P
L
T
A
K
R
-------------
L
T
G
I
V
S
R
G
G
S
I
H
A
K
W
C
L
A
Y
H
K
E
N
F
A
Y
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
G
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
E
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
Q
V
M
N
E
G
P
G
H
V
P
M
H
K
I
P
E
N
M
Q
K
Q
L
E
W
C
N
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
A
R
F
E
F
R
W
M
D
Q
F
A
---
L
S
L
D
P
M
T
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E------------------------------------------
3
PsiBlast_PDB
69.79
65%
31
- C2 -
-
4S2A
1
THIC_CAUCR
A:
[21-612]
--------------------------
I
P
G
S
R
K
V
Y
Q
A
G
E
----
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
------
A
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
G
D
V
E
E
V
-
A
D
P
---------
R
Q
V
K
P
E
D
N
G
F
A
QGK
H
-
L
APEFPDTG
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
-
L
R
R
E
Q
D
R
P
C
V
R
D
-
G
E
D
F
G
A
S
I
P
D
F
V
T
P
E
F
V
R
Q
E
I
A
R
G
R
A
I
I
P
A
N
I
N
H
G
E
L
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
-----
S
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
--
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
R
L
P
F
I
P
M
T
A
K
R
-------------
V
T
G
I
V
S
R
G
G
S
I
M
A
K
W
C
L
A
H
H
K
E
N
F
L
Y
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
G
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
E
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
Q
V
M
I
E
G
P
G
H
V
A
M
H
K
I
K
A
N
M
D
E
Q
L
K
H
C
H
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
A
R
F
E
F
R
W
E
D
Q
F
N
---
L
G
L
D
P
E
T
A
R
K
F
H
D
E
T
L
P
K
E
A
H
K
T
A
H
F
C
S
M
C
G
P
K
F
C
S
M
K
I
S
Q
E
V
R
D
F
A
--
A
G
K
A
P
--
N
S
A
E
L
--
G
M
A
E
M
S
E
K
F
R
E
Q
G
S
E
I
Y
L
K
--------
7
PsiBlast_PDB
69.59
62%
-50
- C2 -
-
4S26
4
THIC_ARATH
A:
[32-527]
------------------------------
K
E
V
V
H
E
E
S
----
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
------
G
G
E
--
P
A
F
D
N
Y
D
T
S
G
----
P
Q
-
N
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
E
-----------
K
L
G
T
P
R
Y
-------------------------------------
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-------------------------
K
L
D
P
E
F
V
R
S
E
V
A
R
G
R
A
I
I
P
S
N
K
K
H
L
E
L
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
-
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
--
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
L
L
R
Y
I
P
L
T
A
K
R
-------------
L
T
G
I
V
S
R
G
G
S
I
H
A
K
W
C
L
A
Y
H
K
E
N
F
A
Y
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
G
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
E
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
Q
V
M
N
E
G
P
G
H
V
P
M
H
K
I
P
E
N
M
Q
K
Q
L
E
W
C
N
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
A
R
F
E
F
R
W
M
D
Q
F
A
---
L
S
L
D
P
M
T
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E
E
N
G
Y
--------------------------------------
25
HHSearch
69.55
67%
-17
- C2 -
-
4S28
5
THIC_ARATH
A:
[19-530]
---------------------
S
F
E
E
C
F
P
K
S
T
K
E
H
K
E
V
V
HEES
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
G
--------
G
E
P
A
F
D
N
Y
D
T
S
G
P
Q
-----
N
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
E
K
L
G
T
-----------------------------------------------
P
-
R
Y
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
K
-
L
------------------------
D
P
E
F
V
R
S
E
V
A
R
G
R
A
I
I
P
S
N
K
K
H
L
E
L
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
-
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
--
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
L
L
R
Y
I
P
L
T
A
K
R
-------------
L
T
G
I
V
S
R
G
G
S
I
H
A
K
W
C
L
A
Y
H
K
E
N
F
A
Y
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
G
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
E
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
Q
V
M
N
E
G
P
G
H
V
P
M
H
K
I
P
E
N
M
Q
K
Q
L
E
W
C
N
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
A
R
F
E
F
R
W
M
D
Q
F
A
---
L
S
L
D
P
M
T
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
--
E
E
N
G
Y
GS
A
---------------------------------
13
PsiBlast_CBE
69.04
62%
-52
- C2 -
-
4S26
4
THIC_ARATH
B:
[32-527]
------------------------------
K
E
V
V
H
E
E
S
----
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
------
G
G
E
--
P
A
F
D
N
Y
D
T
S
G
----
P
Q
-
N
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
E
-----------
K
L
G
T
P
R
Y
-------------------------------------
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-------------------------
K
L
D
P
E
F
V
R
S
E
V
A
R
G
R
A
I
I
P
S
N
K
K
H
L
E
L
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
-
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
--
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
L
L
R
Y
I
P
L
T
A
K
R
-------------
L
T
G
I
V
S
R
G
G
S
I
H
A
K
W
C
L
A
Y
H
K
E
N
F
A
Y
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
G
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
E
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
Q
V
M
N
E
G
P
G
H
V
P
M
H
K
I
P
E
N
M
Q
K
Q
L
E
W
C
N
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
A
R
F
E
F
R
W
M
D
Q
F
A
---
L
S
L
D
P
M
T
A
M
S
F
H
D
E
T
L
P
A
D
G
A
K
V
A
H
F
C
S
M
C
G
P
K
F
C
S
M
K
I
T
E
D
I
R
K
Y
A
E
E
N
G
Y
--------------------------------------
14
Fugue
68.66
68%
-3
- C2 -
-
3EPO
1
THIC_CAUCR
A:
[5-546]
------------
S
T
I
K
A
V
A
E
T
I
S
T
G
P
I
P
G
S
R
K
V
Y
Q
A
G
E
----
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
N
------
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
G
D
V
E
E
V
-
A
D
P
------------
R
Q
V
P
E
F
P
D
---
T
-
G
--------
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
-
L
R
R
E
Q
D
R
P
-
C
V
R
D
G
E
D
F
G
A
S
I
P
D
F
V
T
P
E
F
V
R
Q
E
I
A
R
G
R
A
I
I
P
A
N
I
N
H
G
E
L
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
-
T
-----
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
--
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
R
L
P
F
I
P
M
T
A
K
R
-------------
V
T
G
I
V
S
R
G
G
S
I
M
A
K
W
C
L
A
H
H
K
E
N
F
L
Y
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
G
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
E
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
Q
V
M
I
E
G
P
G
H
V
A
M
H
K
I
K
A
N
M
D
E
Q
L
K
H
C
H
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
A
R
F
E
F
R
W
E
D
Q
F
N
---
L
G
L
D
P
E
T
A
R
K
F
H
------------------------------------------------------------------------------
10
PsiBlast_PDB
68.06
62%
-48
- C2 -
-
4S29
2
THIC_ARATH
A:
[32-488]
------------------------------
K
E
V
V
H
E
E
S
----
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
------
G
G
E
--
P
A
F
D
N
Y
D
T
S
G
----
P
Q
-
N
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
E
-----------
K
L
G
T
P
R
Y
-------------------------------------
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-------------------------
K
L
D
P
E
F
V
R
S
E
V
A
R
G
R
A
I
I
P
S
N
K
K
H
L
E
L
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
-
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
--
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
L
L
R
Y
I
P
L
T
A
K
R
-------------
L
T
G
I
V
S
R
G
G
S
I
H
A
K
W
C
L
A
Y
H
K
E
N
F
A
Y
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
G
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
E
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
Q
V
M
N
E
G
P
G
H
V
P
M
H
K
I
P
E
N
M
Q
K
Q
L
E
W
C
N
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
A
R
F
E
F
R
W
M
D
Q
F
A
---
L
S
L
D
P
M
T
A
M
S
F
H
D
-----------------------------------------------------------------------------
5
PsiBlast_PDB
68.06
62%
-49
- C2 -
-
4N7Q
3
THIC_ARATH
A:
[30-486]
------------------------------
K
E
V
V
H
E
E
S
----
G
-
H
V
L
K
V
P
F
R
R
V
H
L
S
------
G
G
E
--
P
A
F
D
N
Y
D
T
S
G
----
P
Q
-
N
V
N
A
H
I
G
L
A
K
L
R
K
E
W
I
D
R
R
E
-----------
K
L
G
T
P
R
Y
-------------------------------------
T
Q
M
Y
Y
A
K
Q
G
I
I
T
E
E
M
L
Y
C
A
T
R
E
-------------------------
K
L
D
P
E
F
V
R
S
E
V
A
R
G
R
A
I
I
P
S
N
K
K
H
L
E
L
E
P
M
I
V
G
R
K
F
L
V
K
V
N
A
N
I
G
N
-
S
A
V
A
S
S
I
E
E
E
V
Y
K
V
Q
W
A
T
M
W
G
A
D
T
I
M
D
L
S
T
G
R
H
I
H
E
T
R
E
W
I
L
R
N
S
A
V
P
V
G
T
V
P
I
Y
Q
A
L
E
K
V
D
G
I
A
E
N
L
N
W
E
V
F
--
R
E
T
L
I
E
Q
A
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
L
L
R
Y
I
P
L
T
A
K
R
-------------
L
T
G
I
V
S
R
G
G
S
I
H
A
K
W
C
L
A
Y
H
K
E
N
F
A
Y
E
H
W
D
D
I
L
D
I
C
N
Q
Y
D
V
A
L
S
I
G
D
G
L
R
P
G
S
I
Y
D
A
N
D
T
A
Q
F
A
E
L
L
T
Q
G
E
L
T
R
R
A
W
E
K
D
V
Q
V
M
N
E
G
P
G
H
V
P
M
H
K
I
P
E
N
M
Q
K
Q
L
E
W
C
N
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
N
I
G
A
L
G
T
A
L
L
C
Y
V
T
P
K
E
H
L
G
L
P
N
R
D
D
V
K
A
G
V
I
A
Y
K
I
A
A
H
A
A
D
L
A
K
Q
H
P
H
A
Q
A
W
D
D
A
L
S
K
A
R
F
E
F
R
W
M
D
Q
F
A
---
L
S
L
D
P
M
T
A
M
S
F
H
D
-----------------------------------------------------------------------------
23
HHSearch
67.86
67%
9
- C2 -
-
3EPO
1
THIC_CAUCR
A:
[10-546]
-----------------
V
A
E
T
I
S
T
G
P
I
P
G
S
R
K
V
Y
Q
A
G
E
----
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
A
------
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
G
D
V
E
E
V
A
D
P
R
Q
V
--------------
P
E
F
P
---
D
T
G
--------
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
-
L
R
R
E
Q
D
R
P
-
C
V
R
D
G
E
D
F
G
A
S
I
P
D
F
V
T
P
E
F
V
R
Q
E
I
A
R
G
R
A
I
I
P
A
N
I
N
H
G
E
L
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
------
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
--
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
R
L
P
F
I
P
M
T
A
K
R
-------------
V
T
G
I
V
S
R
G
G
S
I
M
A
K
W
C
L
A
H
H
K
E
N
F
L
Y
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
G
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
E
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
Q
V
M
I
E
G
P
G
H
V
A
M
H
K
I
K
A
N
M
D
E
Q
L
K
H
C
H
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
A
R
F
E
F
R
W
E
D
Q
F
N
---
L
G
L
D
P
E
T
A
R
K
F
H
------------------------------------------------------------------------------
2
PsiBlast_PDB
65.91
65%
21
- C2 -
-
3EPO
1
THIC_CAUCR
A:
[19-546]
--------------------------
I
P
G
S
R
K
V
Y
Q
A
G
E
----
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
------
A
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
G
D
V
E
E
V
-
A
D
P
---------
R
Q
V
--------------PEFPDTG-
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
-
L
R
R
E
Q
D
R
P
C
V
R
D
-
G
E
D
F
G
A
S
I
P
D
F
V
T
P
E
F
V
R
Q
E
I
A
R
G
R
A
I
I
P
A
N
I
N
H
G
E
L
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
------
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
--
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
R
L
P
F
I
P
M
T
A
K
R
-------------
V
T
G
I
V
S
R
G
G
S
I
M
A
K
W
C
L
A
H
H
K
E
N
F
L
Y
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
G
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
E
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
Q
V
M
I
E
G
P
G
H
V
A
M
H
K
I
K
A
N
M
D
E
Q
L
K
H
C
H
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
A
R
F
E
F
R
W
E
D
Q
F
N
---
L
G
L
D
P
E
T
A
R
K
F
H
------------------------------------------------------------------------------
1
PsiBlast_PDB
65.82
65%
20
- C2 -
-
3EPN
1
THIC_CAUCR
A:
[19-546]
--------------------------
I
P
G
S
R
K
V
Y
Q
A
G
E
----
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
------
A
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
G
D
V
E
E
V
-
A
D
P
---------
R
Q
V
--------------PEFPDTG-
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
-
L
R
R
E
Q
D
R
P
C
V
R
D
-
G
E
D
F
G
A
S
I
P
D
F
V
T
P
E
F
V
R
Q
E
I
A
R
G
R
A
I
I
P
A
N
I
N
H
G
E
L
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
------
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
--
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
R
L
P
F
I
P
M
T
A
K
R
-------------
V
T
G
I
V
S
R
G
G
S
I
M
A
K
W
C
L
A
H
H
K
E
N
F
L
Y
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
G
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
E
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
Q
V
M
I
E
G
P
G
H
V
A
M
H
K
I
K
A
N
M
D
E
Q
L
K
H
C
H
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
A
R
F
E
F
R
W
E
D
Q
F
N
---
L
G
L
D
P
E
T
A
R
K
F
H
------------------------------------------------------------------------------
4
PsiBlast_PDB
65.23
63%
25
- C2 -
-
3EPM
1
THIC_CAUCR
A:
[19-546]
--------------------------
I
P
G
S
R
K
V
Y
Q
A
G
E
----
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
------
A
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
G
D
V
E
E
V
-
A
D
P
---------
R
Q
---------------APEFPDTG
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
L
R
R
E
Q
D
R
P
C
V
R
D
--
G
E
D
F
G
A
S
I
P
D
F
V
T
P
E
F
V
R
Q
E
I
A
R
G
R
A
I
I
P
A
N
I
N
H
G
E
L
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
------
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
--
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
R
L
P
F
I
P
M
T
A
K
R
-------------
V
T
G
I
V
S
R
G
G
S
I
M
A
K
W
C
L
A
H
H
K
E
N
F
L
Y
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
G
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
E
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
Q
V
M
I
E
G
P
G
H
V
A
M
H
K
I
K
A
N
M
D
E
Q
L
K
H
C
H
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
A
R
F
E
F
R
W
E
D
Q
F
N
---
L
G
L
D
P
E
T
A
R
K
F
H
------------------------------------------------------------------------------
11
PsiBlast_CBE
65.19
65%
36
- C2 -
-
3EPO
1
THIC_CAUCR
B:
[19-548]
--------------------------
I
P
G
S
R
K
V
Y
Q
A
G
E
----
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
------
A
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
G
D
V
E
E
V
-
A
D
P
---------
R
Q
V
K
P
------------PEFPG---
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
-
L
R
R
E
Q
D
R
P
C
V
R
D
-
G
E
D
F
G
A
S
I
P
D
F
V
T
P
E
F
V
R
Q
E
I
A
R
G
R
A
I
I
P
A
N
I
N
H
G
E
L
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
------
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
--
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
R
L
P
F
I
P
M
T
A
K
R
-------------
V
T
G
I
V
S
R
G
G
S
I
M
A
K
W
C
L
A
H
H
K
E
N
F
L
Y
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
G
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
E
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
Q
V
M
I
E
G
P
G
H
V
A
M
H
K
I
K
A
N
M
D
E
Q
L
K
H
C
H
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
A
R
F
E
F
R
W
E
D
Q
F
N
---
L
G
L
D
P
E
T
A
R
K
F
H
D
E
----------------------------------------------------------------------------
12
PsiBlast_CBE
64.99
65%
34
- C2 -
-
3EPN
1
THIC_CAUCR
B:
[19-546]
--------------------------
I
P
G
S
R
K
V
Y
Q
A
G
E
----
L
F
P
E
L
R
V
P
F
R
E
V
A
V
H
P
S
------
A
N
E
P
P
V
T
I
Y
D
P
S
G
P
Y
S
D
P
A
I
Q
I
D
I
E
K
G
L
P
R
T
R
E
A
L
V
V
A
R
G
D
V
E
E
V
-
A
D
P
---------
R
Q
V
--------------PEFPG---
R
K
I
Y
R
A
K
P
G
K
L
V
T
Q
L
E
Y
A
R
A
G
I
I
T
A
E
M
E
Y
V
A
I
R
E
N
-
L
R
R
E
Q
D
R
P
C
V
R
D
-
G
E
D
F
G
A
S
I
P
D
F
V
T
P
E
F
V
R
Q
E
I
A
R
G
R
A
I
I
P
A
N
I
N
H
G
E
L
E
P
M
A
I
G
R
N
F
L
V
K
I
N
A
N
I
G
N
------
T
V
A
D
E
V
D
K
L
V
W
A
T
R
W
G
A
D
T
V
M
D
L
S
T
G
R
N
I
H
N
I
R
D
W
I
I
R
N
S
S
V
P
I
G
T
V
P
I
Y
Q
A
L
E
K
V
N
G
V
A
E
D
L
N
W
E
V
F
--
R
D
T
L
I
E
Q
C
E
Q
G
V
D
Y
F
T
I
H
A
G
--
V
R
L
P
F
I
P
M
T
A
K
R
-------------
V
T
G
I
V
S
R
G
G
S
I
M
A
K
W
C
L
A
H
H
K
E
N
F
L
Y
E
R
F
D
E
I
C
E
I
M
R
A
Y
D
V
S
F
S
L
G
D
G
L
R
P
G
S
T
A
D
A
N
D
E
A
Q
F
S
E
L
R
T
L
G
E
L
T
K
V
A
W
K
H
G
V
Q
V
M
I
E
G
P
G
H
V
A
M
H
K
I
K
A
N
M
D
E
Q
L
K
H
C
H
E
A
P
F
Y
T
L
G
P
L
T
T
D
I
A
P
G
Y
D
H
I
T
S
A
I
G
A
A
M
I
G
W
F
G
T
A
M
L
C
Y
V
T
P
K
E
H
L
G
L
P
D
R
D
D
V
K
T
G
V
I
T
Y
K
L
A
A
H
A
A
D
L
A
K
G
H
P
G
A
A
M
W
D
D
A
I
S
R
A
R
F
E
F
R
W
E
D
Q
F
N
---
L
G
L
D
P
E
T
A
R
K
F
H
------------------------------------------------------------------------------
37
HHSearch
40.75
27%
-203
- C2 -
-
1MZH
-
DEOC_AQUAE
A:
[129-154]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
E
E
E
I
--
K
K
A
V
E
I
C
I
E
A
G
A
D
F
I
K
T
S
T
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
28.52
18%
-10
- C2 -
-
4IMP
1
?
A:
[31-550]
---
S
D
P
A
A
G
W
F
W
Q
A
V
A
R
Q
D
L
K
S
V
S
D
A
L
D
L
D
A
D
A
P
L
S
A
T
----
L
-
P
A
L
S
V
W
H
R
Q
E
R
E
R
V
L
A
D
G
W
---------
R
Y
R
V
D
W
V
R
V
A
P
-------
Q
P
V
R
R
T
R
E
T
W
L
L
V
V
P
P
-----
G
G
I
E
E
A
L
V
E
R
L
T
D
A
L
N
T
R
G
I
S
T
L
---
R
-
L
--------
D
V
P
P
A
A
T
S
G
E
L
A
T
E
L
R
A
A
A
D
G
--
D
P
V
K
A
I
L
S
L
--------
T
A
L
D
E
R
P
H
P
E
--------
C
K
D
V
P
S
G
I
A
L
L
L
N
L
V
K
A
L
G
E
A
D
L
R
I
P
-
L
W
T
I
T
R
G
A
V
K
A
G
P
A
D
R
L
L
R
P
-
M
Q
A
Q
A
W
G
L
G
R
V
A
A
L
E
H
P
E
R
W
G
G
--
L
I
D
L
P
-----------------------------
D
S
L
D
G
D
V
L
T
R
L
G
E
A
L
--
T
N
G
L
A
E
------
D
Q
L
A
I
R
Q
S
G
V
L
A
R
R
L
V
P
A
P
A
N
Q
PAGRK
W
R
P
R
G
S
A
L
I
T
G
G
L
G
A
V
G
A
Q
V
A
R
W
L
A
E
I
G
A
E
R
I
V
L
T
S
R
R
-----
G
N
Q
A
A
G
A
A
E
L
E
A
E
L
R
A
---
L
G
A
Q
V
S
I
V
A
C
D
V
T
D
R
A
E
M
S
A
L
L
A
E
F
D
V
T
A
V
F
H
A
A
G
V
G
R
L
L
P
L
A
E
---------------------
T
D
----
Q
N
G
L
A
E
I
C
A
A
K
V
R
G
A
Q
V
L
D
E
L
C
--------------
D
S
T
D
L
D
A
F
V
L
F
S
S
G
A
G
V
W
G
G
G
G
Q
G
A
Y
G
A
A
N
A
F
L
D
T
L
A
E
Q
R
R
A
R
G
L
P
A
T
S
I
S
W
G
S
W
A
G
G
G
M
A
D
G
--
A
A
G
E
H
L
R
R
R
G
I
R
P
M
P
A
A
S
A
I
L
A
L
Q
E
V
L
D
Q
D
E
--
T
C
V
S
I
--
A
D
V
D
W
D
R
F
V
P
T
F
A
A
---
T
R
A
T
R
L
F
D
E
V
P
A
A
R
K
AM
19
Fugue
25.82
16%
-8
- C2 -
-
1TUB
1
TBA1A_PIG
A:
[1-440]
M
R
E
C
I
S
I
H
---
V
G
Q
A
G
V
Q
I
G
N
A
C
W
E
L
Y
C
L
E
H
G
I
Q
P
D
G
Q
--------
M
P
--------
S
D
K
T
I
G
G
G
D
D
S
F
N
T
F
F
S
E
T
G
A
G
K
H
V
P
R
A
V
F
V
D
L
E
---
P
T
V
I
D
E
V
R
T
G
T
Y
R
Q
L
F
H
-
P
E
Q
L
I
T
G
K
-
E
---------------------------------
D
A
A
N
N
Y
A
R
G
H
Y
T
-----------------------------------
I
G
K
E
I
I
D
L
V
L
D
R
I
R
K
L
A
D
Q
C
T
G
----------------
L
Q
G
F
S
V
F
H
S
F
G
G
G
T
G
S
G
F
T
S
L
L
M
E
R
L
S
V
D
-----
Y
G
K
K
S
K
L
E
F
S
-----------
I
Y
P
A
P
Q
V
S
T
A
V
V
E
P
Y
N
S
I
L
T
T
H
T
T
L
E
H
S
D
C
A
F
M
VD
N
E
A
I
Y
D
I
C
R
R
N
L
D
I
E
R
P
T
Y
T
--
N
L
N
R
L
I
G
Q
I
V
S
S
-------------
I
T
A
S
L
R
F
D
G
A
--------------
L
N
V
D
L
T
E
F
Q
T
N
L
V
P
Y
P
R
G
H
F
P
L
A
T
Y
A
P
----
V
I
S
A
E
K
A
Y
H
E
Q
L
S
V
A
E
I
T
N
A
C
F
E
P
A
N
Q
M
V
K
C
D
P
R
H
-------------
G
K
Y
M
A
C
C
L
L
Y
R
G
D
V
V
P
K
D
V
N
A
A
I
A
T
I
K
T
K
R
T
I
Q
F
V
D
W
C
P
T
G
F
K
V
G
I
N
Y
E
P
P
T
V
V
P
-----------------
G
G
D
L
A
K
V
Q
R
A
V
C
M
L
S
N
T
T
A
I
A
E
A
W
A
R
L
D
H
K
F
D
---
L
M
Y
A
K
R
A
F
V
H
W
Y
V
G
E
------------
G
M
E
E
G
E
F
------------------------
S
E
A
R
E
D
M
A
A
L
E
K
D
Y
E
E
V
G
V
D
S
V
----------