@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMG0: (2017-11-08 )
MTDATAGKIPHVLVIMDGVGHREAIEDNAFLAAKNPNLTAMKAKHPNSLISGSGEDVGLPDGQMGNSEVGHMNLGAGRVLYQDFTRITKDIRTGAFFEHEVLVDAVEKAKAAGGAVHIMGLLSEGGVHSHEDHIVAMCELALKRGAKVYLHAFLDGRDTPPRSAQPSLEKLDALFAQYEGKGRIATMIGRYFAMDRDNRWDRVEQAYRLLTEGEAVRTATTAVEGLELAYAANENDEFVKATRIGEIAKVQDGDSVVFMNFRADRAREITHAFVEKDFAGFERTVVPNLSKFVMLTRYQASIDAPVAYMPEELKNSLGEYLSSLGKTQLRIAETEKYAHVTFFFSGGREDEYPGEKRILIPSPNVATYDLKPEMSAYEVTDELVKAINSGEYDLLVVNYANGDMVGHTGVFDAAVKAVEAVDTCLGRVYEAVMAKKGHMLITADHGNVEQMQDYESGQVHTQHTTELVPFIYVGPTQATIAEGGVLADVAPTILNLMQIPVPAEMQGRNLITLSA
Atome Classification :
(21 SA)
.........10........20........30........40......-..50........60.........70........80........90........100.......110.......120.......130.......140....-.-..150.......160.......170.......180---.......190-....-...200.......210...--....220........230.......240..-----..-----.-.-----.250.......260.......270.......280.-.-.-.-...290.......300.......--310.......320.......330.......340.......350.......--360.......370.......380.......390.......400.......410.......420.......430.......440.......450...---------....--460.......-------470..-----....---.480.......490.......500.......510...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTDATAGKI
P
H
V
L
V
I
MDGVG
H
R
E
AIEDN
A
F
L
AAKNPN
L
T
A
M
KAKHPN-SLISGSGEDVGLP-DGQMGNSEVG
H
M
NLGA
G
R
V
L
Y
Q
D
F
T
R
I
T
K
D
I
RTGAF
F
E
H
E
V
L
V
D
A
V
E
K
A
KAAG
G
A
V
H
I
M
G
L
L
SEGGVHSHE
D
H
I
V
A
M
C
E
L
A
L
KRG
A
-
K
-
V
Y
L
H
A
F
LDGRDTPPRSAQP
S
L
E
K
L
D
A
L
F
A
QYEGK
G
---
R
I
A
T
M
I
G
R
Y
F-AMDR-DN
R
W
D
R
V
E
Q
A
Y
R
L
LTEGE
A
--
V
R
T
A
T
-
T
AVE
G
L
E
L
A
Y
AANENDE
F
V
K
A
TRI-----G
E
-----
I
-
A
-----
K
VQDG
D
S
V
V
F
M
NFRA
D
R
A
R
E
I
T
H
A
F
V
E
K
D
FAGFE
R
-
T
-V-V-P
N
L
S
K
F
V
M
L
T
R
YQASIDAPVAYM--
P
E
E
L
K
N
S
L
G
E
Y
L
S
SLGKT
Q
L
R
I
A
ETE
K
Y
A
H
V
T
F
F
F
SGGREDEYPGE
K
R
I
L
--IPSPN
V
A
T
Y
DLKPEM
S
A
Y
E
V
T
D
E
L
V
K
A
I
NSGEY
D
L
L
V
V
N
YANGDMVGHT
G
V
F
D
A
A
V
K
A
V
E
A
V
D
T
C
L
G
R
V
Y
E
A
V
M
AKKG
H
M
L
I
T
ADHG
N
V
E
Q
M
Q
DYE---------SG
Q
V
--
H
T
Q
HTT
E
L
V
P
-------
F
I
Y
VG-----PTQ
A
---
T
IAEG
G
V
L
A
D
V
A
P
T
I
L
N
L
M
QIPVPAEMQG
R
N
L
I
T
LSA
27
HHSearch
95.73
99%
-75
- C3 -
-
5VPU
8
?
A:
[14-522]
-----
A
G
K
I
P
H
V
L
V
I
M
D
G
V
G
H
R
E
A
I
E
D
N
A
F
L
A
A
K
T
P
N
L
T
A
M
K
A
K
H
P
N
-
S
L
I
S
G
S
G
E
D
V
G
L
P
-
D
G
Q
M
G
N
S
E
V
G
H
M
N
L
G
A
G
R
V
L
Y
Q
D
F
T
R
I
T
K
D
I
R
T
G
A
F
F
E
H
E
V
L
V
D
A
V
E
K
A
K
A
A
G
G
A
V
H
I
M
G
L
L
S
E
G
G
V
H
S
H
E
D
H
I
V
A
M
C
E
L
A
L
K
R
G
A
-
K
-
V
Y
L
H
A
F
L
D
G
R
D
T
P
P
R
S
A
Q
P
S
L
E
K
L
D
A
L
F
A
Q
Y
E
G
K
G
---
R
I
A
T
M
I
G
R
Y
F
-
A
M
D
R
-
D
N
R
W
D
R
V
E
Q
A
Y
R
L
L
T
E
G
E
A
--
V
R
T
A
T
-
T
A
V
E
G
L
E
L
A
Y
A
A
N
E
N
D
E
F
V
K
A
T
R
I
-----
G
E
-----
I
-
A
-----
K
V
Q
D
G
D
S
V
V
F
M
N
F
R
A
D
R
A
R
E
I
T
R
A
F
V
E
K
D
F
A
G
F
E
R
-
K
-
V
-
V
-
P
N
L
S
K
F
V
M
L
T
R
Y
Q
A
S
I
D
A
P
V
A
Y
M
--
P
E
E
L
K
N
S
L
G
E
Y
L
S
S
L
G
K
T
Q
L
R
I
A
E
T
E
K
Y
A
H
V
T
F
F
F
S
G
G
R
E
D
E
Y
P
G
E
K
R
I
L
--
I
P
S
P
N
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
E
L
V
K
A
I
N
S
G
E
Y
D
L
L
V
V
N
Y
A
N
G
D
M
V
G
H
T
G
V
F
D
A
A
V
K
A
V
E
A
V
D
T
C
L
G
R
V
Y
E
A
V
M
A
K
K
G
H
M
L
I
T
A
D
H
G
N
V
E
Q
M
Q
D
Y
E
---------
S
G
Q
V
--
H
T
Q
H
T
T
E
L
V
P
-------
F
I
Y
V
G
-----
P
T
Q
A
---
T
I
A
E
G
G
V
L
A
D
V
A
P
T
I
L
N
L
M
Q
I
P
V
P
A
E
M
Q
G
R
N
L
I
T
L
S
-
1
PsiBlast_PDB
95.73
99%
-75
- C3 -
-
5VPU
8
?
A:
[14-522]
-----
A
G
K
I
P
H
V
L
V
I
M
D
G
V
G
H
R
E
A
I
E
D
N
A
F
L
A
A
K
T
P
N
L
T
A
M
K
A
K
H
P
N
-
S
L
I
S
G
S
G
E
D
V
G
L
P
-
D
G
Q
M
G
N
S
E
V
G
H
M
N
L
G
A
G
R
V
L
Y
Q
D
F
T
R
I
T
K
D
I
R
T
G
A
F
F
E
H
E
V
L
V
D
A
V
E
K
A
K
A
A
G
G
A
V
H
I
M
G
L
L
S
E
G
G
V
H
S
H
E
D
H
I
V
A
M
C
E
L
A
L
K
R
G
A
-
K
-
V
Y
L
H
A
F
L
D
G
R
D
T
P
P
R
S
A
Q
P
S
L
E
K
L
D
A
L
F
A
Q
Y
E
G
K
G
---
R
I
A
T
M
I
G
R
Y
F
-
A
M
D
R
-
D
N
R
W
D
R
V
E
Q
A
Y
R
L
L
T
E
G
E
A
--
V
R
T
A
T
-
T
A
V
E
G
L
E
L
A
Y
A
A
N
E
N
D
E
F
V
K
A
T
R
I
-----
G
E
-----
I
-
A
-----
K
V
Q
D
G
D
S
V
V
F
M
N
F
R
A
D
R
A
R
E
I
T
R
A
F
V
E
K
D
F
A
G
F
E
R
-
K
-
V
-
V
-
P
N
L
S
K
F
V
M
L
T
R
Y
Q
A
S
I
D
A
P
V
A
Y
M
--
P
E
E
L
K
N
S
L
G
E
Y
L
S
S
L
G
K
T
Q
L
R
I
A
E
T
E
K
Y
A
H
V
T
F
F
F
S
G
G
R
E
D
E
Y
P
G
E
K
R
I
L
--
I
P
S
P
N
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
E
L
V
K
A
I
N
S
G
E
Y
D
L
L
V
V
N
Y
A
N
G
D
M
V
G
H
T
G
V
F
D
A
A
V
K
A
V
E
A
V
D
T
C
L
G
R
V
Y
E
A
V
M
A
K
K
G
H
M
L
I
T
A
D
H
G
N
V
E
Q
M
Q
D
Y
E
---------
S
G
Q
V
--
H
T
Q
H
T
T
E
L
V
P
-------
F
I
Y
V
G
-----
P
T
Q
A
---
T
I
A
E
G
G
V
L
A
D
V
A
P
T
I
L
N
L
M
Q
I
P
V
P
A
E
M
Q
G
R
N
L
I
T
L
S
-
9
PsiBlast_PDB
70.65
48%
9
- C3 -
-
4NWX
2
?
A:
[11-511]
-------
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
A
K
F
N
E
L
-
G
I
G
---
Q
F
A
S
V
S
G
R
Y
Y
-
A
M
D
R
-
D
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
---
P
T
Y
A
-
T
A
K
E
G
V
E
A
S
Y
N
E
G
L
T
D
E
F
V
V
P
F
I
V
E
----
N
Q
-----
N
-
D
-----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
-
E
-
Q
-
V
-
K
D
L
F
-
Y
A
T
F
T
K
Y
N
D
N
I
D
A
A
I
V
F
E
--
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
M
V
G
H
S
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
-
D
---------
D
D
Q
P
--
M
T
T
H
T
T
N
P
V
P
-------
V
I
-
V
T
-----
K
E
G
V
---
T
L
R
E
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
----
2
PsiBlast_PDB
70.50
49%
-5
- C3 -
-
2IFY
-
GPMI_BACAN
A:
[3-507]
---------
P
T
A
L
I
I
L
D
G
F
G
L
R
E
E
T
Y
G
N
A
V
A
Q
A
K
K
P
N
F
D
G
Y
W
N
K
F
P
H
-
T
T
L
T
A
C
G
E
A
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
V
N
V
A
I
R
E
G
E
F
D
K
N
E
T
F
Q
S
A
I
K
S
V
K
E
K
G
T
A
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
M
N
H
M
F
A
L
L
R
L
A
A
K
E
G
V
E
K
-
V
Y
I
H
A
F
L
D
G
R
D
V
G
P
K
T
A
Q
S
Y
I
D
A
T
N
E
V
I
K
E
-
T
G
V
G
---
Q
F
A
T
I
S
G
R
Y
Y
-
S
M
D
R
-
D
K
R
W
D
R
V
E
K
C
Y
R
A
M
V
N
G
E
G
---
P
T
Y
K
-
S
A
E
E
C
V
E
D
S
Y
A
N
G
I
Y
D
E
F
V
L
P
S
V
I
V
N
EDN
T
P
-----
V
-
A
-----
T
I
N
D
D
D
A
V
I
F
Y
N
F
R
P
D
R
A
I
Q
I
A
R
V
F
T
N
G
D
F
R
E
F
D
R
G
E
-
K
-
V
-
P
H
I
P
E
F
V
C
M
T
H
F
S
E
T
V
D
G
Y
V
A
F
K
--
P
M
N
L
D
N
T
L
G
E
V
V
A
Q
A
G
L
K
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
F
S
G
G
R
E
A
E
F
P
G
E
E
R
I
L
--
I
N
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
I
Y
E
V
T
D
A
L
V
N
E
I
E
N
D
K
H
D
V
I
I
L
N
F
A
N
C
D
M
V
G
H
S
G
M
M
E
P
T
I
K
A
V
E
A
T
D
E
C
L
G
K
V
V
E
A
I
L
A
K
D
G
V
A
L
I
T
A
D
H
G
N
A
D
E
E
L
T
S
E
----------
G
E
P
--
M
T
A
H
T
T
N
P
V
P
-------
F
I
-
V
T
-----
K
N
D
V
---
E
L
R
E
D
G
I
L
G
D
I
A
P
T
M
L
T
L
L
G
V
E
Q
P
K
E
M
T
G
K
T
I
I
----
8
PsiBlast_PDB
70.22
48%
8
- C3 -
-
4NWJ
1
?
A:
[10-511]
------
A
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
A
K
F
N
E
L
-
G
I
G
---
Q
F
A
S
V
S
G
R
Y
Y
-
A
M
D
R
-
D
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
---
P
T
Y
A
-
T
A
K
E
G
V
E
A
S
Y
N
E
G
L
T
D
E
F
V
V
P
F
I
V
E
----
N
Q
-----
N
-
D
-----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
-
E
-
Q
-
V
-
K
D
L
F
-
Y
A
T
F
T
K
Y
N
D
N
I
D
A
A
I
V
F
E
--
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
M
V
G
H
S
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
-
D
---------
D
D
Q
P
--
M
T
T
H
T
T
N
P
V
P
-------
V
I
-
V
T
-----
K
E
G
V
---
T
L
R
E
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
----
52
Fugue
70.17
49%
1
- C3 -
-
1EJJ
1
GPMI_GEOSE
A:
[3-510]
-------
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
K
R
-
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
E
Y
-
G
V
G
---
E
I
A
T
L
S
G
R
Y
Y
-
S
M
D
R
-
D
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
---
P
T
Y
R
-
D
P
L
E
C
I
E
D
S
Y
K
H
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
R
EDGRP
V
-
A
-----
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
G
P
-
K
-
H
-
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
V
A
G
Y
V
A
F
K
--
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
V
G
H
S
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
-
P
---------
D
G
K
P
--
Q
T
A
H
T
T
N
P
V
P
-------
V
I
V
T
K
-----
K
-
G
I
---
K
L
R
D
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
---
30
HHSearch
70.15
50%
-7
- C3 -
-
2IFY
-
GPMI_BACAN
A:
[1-508]
-------
R
K
P
T
A
L
I
I
L
D
G
F
G
L
R
E
E
T
Y
G
N
A
V
A
Q
A
K
K
P
N
F
D
G
Y
W
N
K
F
P
H
-
T
T
L
T
A
C
G
E
A
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
V
N
V
A
I
R
E
G
E
F
D
K
N
E
T
F
Q
S
A
I
K
S
V
K
E
K
G
T
A
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
M
N
H
M
F
A
L
L
R
L
A
A
K
E
G
V
E
K
-
V
Y
I
H
A
F
L
D
G
R
D
V
G
P
K
T
A
Q
S
Y
I
D
A
T
N
E
V
I
K
E
T
G
-
V
G
---
Q
F
A
T
I
S
G
R
Y
Y
-
S
M
D
R
-
D
K
R
W
D
R
V
E
K
C
Y
R
A
M
V
N
G
E
G
--
P
-
T
Y
K
-
S
A
E
E
C
V
E
D
S
Y
A
N
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
N
-----
E
-
D
NTPVA
T
I
N
D
D
D
A
V
I
F
Y
N
F
R
P
D
R
A
I
Q
I
A
R
V
F
T
N
G
D
F
R
E
F
D
R
-
G
E
K
-
V
-
P
H
I
P
E
F
V
C
M
T
H
F
S
E
T
V
D
G
Y
V
A
F
K
--
P
M
N
L
D
N
T
L
G
E
V
V
A
Q
A
G
L
K
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
F
S
G
G
R
E
A
E
F
P
G
E
E
R
I
L
--
I
N
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
I
Y
E
V
T
D
A
L
V
N
E
I
E
N
D
K
H
D
V
I
I
L
N
F
A
N
C
D
M
V
G
H
S
G
M
M
E
P
T
I
K
A
V
E
A
T
D
E
C
L
G
K
V
V
E
A
I
L
A
K
D
G
V
A
L
I
T
A
D
H
G
N
A
D
E
E
L
T
S
----------
E
G
E
P
--
M
T
A
H
T
T
N
P
V
P
-------
F
I
V
T
K
-----
N
D
V
E
----
L
R
E
D
G
I
L
G
D
I
A
P
T
M
L
T
L
L
G
V
E
Q
P
K
E
M
T
G
K
T
I
I
K
---
10
PsiBlast_PDB
69.81
48%
10
- C3 -
-
4QAX
1
?
A:
[11-511]
-------
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
A
K
F
N
E
L
-
G
I
G
---
Q
F
A
S
V
S
G
R
Y
Y
-
A
M
D
R
-
D
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
---
P
T
Y
A
-
T
A
K
E
G
V
E
A
S
Y
N
E
G
L
T
D
E
F
V
V
P
F
I
V
E
----
N
Q
-----
N
-
D
-----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
-
E
-
Q
-
V
-
K
D
L
F
-
Y
A
T
F
T
K
Y
N
D
N
I
D
A
A
I
V
F
E
--
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
M
V
G
H
S
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
-
D
---------
D
D
Q
P
--
M
T
T
H
T
T
N
P
V
P
-------
V
I
-
V
T
-----
K
E
G
V
---
T
L
R
E
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
----
7
PsiBlast_PDB
69.79
48%
10
- C3 -
-
4MY4
-
?
A:
[11-511]
-------
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
A
K
F
N
E
L
-
G
I
G
---
Q
F
A
S
V
S
G
R
Y
Y
-
A
M
D
R
-
D
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
---
P
T
Y
A
-
T
A
K
E
G
V
E
A
S
Y
N
E
G
L
T
D
E
F
V
V
P
F
I
V
E
----
N
Q
-----
N
-
D
-----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
-
E
-
Q
-
V
-
K
D
L
F
-
Y
A
T
F
T
K
Y
N
D
N
I
D
A
A
I
V
F
E
--
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
M
V
G
H
S
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
-
D
---------
D
D
Q
P
--
M
T
T
H
T
T
N
P
V
P
-------
V
I
-
V
T
-----
K
E
G
V
---
T
L
R
E
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
----
31
HHSearch
69.60
49%
-2
- C3 -
-
1O98
1
GPMI_GEOSE
A:
[2-510]
------
S
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
K
R
-
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
E
Y
G
-
V
G
---
E
I
A
T
L
S
G
R
Y
Y
-
S
M
D
R
-
D
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
--
P
-
T
Y
R
-
D
P
L
E
C
I
E
D
S
Y
K
H
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
R
-----
E
-
D
GRPVA
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
-
G
-
P
K
H
-
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
V
A
G
Y
V
A
F
K
--
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
V
G
H
S
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
P
----------
D
G
K
P
--
Q
T
A
H
T
T
N
P
V
P
-------
V
I
V
T
K
-----
K
G
I
K
----
L
R
D
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
---
28
HHSearch
69.57
48%
7
- C3 -
-
4NWJ
1
?
A:
[10-512]
------
A
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
A
K
F
N
E
L
G
-
I
G
---
Q
F
A
S
V
S
G
R
Y
Y
-
A
M
D
R
-
D
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
--
P
-
T
Y
A
-
T
A
K
E
G
V
E
A
S
Y
N
E
G
L
T
D
E
F
V
V
P
F
I
V
-----
E
N
-----
Q
-
N
D----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
-
E
---
Q
-
V
K
D
L
F
Y
A
T
F
T
K
Y
N
D
N
I
D
A
A
I
V
F
E
--
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
M
V
G
H
S
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
D
----------
D
D
Q
P
--
M
T
T
H
T
T
N
P
V
P
-------
V
I
V
T
K
-----
E
G
V
----
T
L
R
E
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
---
6
PsiBlast_PDB
69.46
48%
2
- C3 -
-
1O99
1
GPMI_GEOSE
A:
[3-509]
-------
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
M
G
N
A
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
E
Y
-
G
V
G
---
E
I
A
T
L
S
G
R
Y
Y
-
S
M
D
R
-
D
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
---
P
T
Y
R
-
D
P
L
E
C
I
E
D
S
Y
K
H
G
I
Y
D
E
F
V
L
P
S
V
I
V
R
EDG
R
P
-----
V
-
A
-----
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
-
G
-
P
-
K
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
V
A
G
Y
V
A
F
K
--
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
V
G
H
S
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
-
P
---------
D
G
K
P
--
Q
T
A
H
T
T
N
P
V
P
-------
V
I
-
V
T
-----
K
K
G
I
---
K
L
R
D
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
----
32
HHSearch
69.24
42%
-21
- C3 -
-
5KGN
1
GPMI_CAEEL
B:
[3-521]
M
A
N
N
S
S
V
A
N
K
V
C
L
I
V
I
D
G
W
G
V
S
E
D
P
Y
G
N
A
I
L
N
A
Q
T
P
V
M
D
K
L
C
S
G
N
-
W
-
A
Q
I
E
A
H
G
L
H
V
G
L
P
-
E
G
L
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
V
I
Y
Q
D
I
V
R
I
N
L
A
V
K
N
N
K
F
V
T
N
E
S
L
V
D
A
C
D
R
A
K
N
G
N
G
R
L
H
L
A
G
L
V
S
D
G
G
V
H
S
H
I
D
H
M
F
A
L
V
K
A
I
K
E
L
G
V
P
E
-
L
Y
L
H
F
Y
G
D
G
R
D
T
S
P
N
S
G
V
G
F
L
E
Q
T
L
E
F
L
E
K
T
T
G
Y
G
---
K
L
A
T
V
V
G
R
Y
Y
-
A
M
D
R
-
D
N
R
W
E
R
I
N
V
A
Y
E
A
M
I
G
G
V
G
--
E
T
S
D
E
A
G
V
V
E
V
V
R
K
R
Y
A
A
D
E
T
D
E
F
L
K
P
I
I
L
-----
Q
G
-----
E
K
G
-----
R
V
Q
N
D
D
T
I
I
F
F
D
Y
R
A
D
R
M
R
E
I
S
A
A
M
G
M
D
R
Y
K
D
C
N
S
-
K
-
L
A
H
-
P
S
N
L
Q
V
Y
G
M
T
Q
Y
K
A
E
F
P
F
K
S
L
F
P
--
P
A
S
N
K
N
V
L
A
E
W
L
A
E
Q
K
V
S
Q
F
H
C
A
E
T
E
K
Y
A
H
V
T
F
F
F
N
G
G
L
E
K
Q
F
E
G
E
E
R
C
L
--
V
P
S
P
K
V
A
T
Y
D
L
Q
P
E
M
S
A
A
G
V
A
D
K
M
I
E
Q
L
E
A
G
T
H
P
F
I
M
C
N
F
A
P
P
D
M
V
G
H
T
G
V
Y
E
A
A
V
K
A
C
E
A
T
D
I
A
I
G
R
I
Y
E
A
T
Q
K
H
G
Y
S
L
M
V
T
A
D
H
G
N
A
E
K
M
K
A
P
D
----------
G
G
K
--
H
T
A
H
T
C
Y
R
V
P
-------
L
T
L
S
H
-----
P
G
F
K
F
V
D
P
A
D
R
H
P
A
L
C
D
V
A
P
T
V
L
A
I
M
G
L
P
Q
P
A
E
M
T
G
V
S
I
V
Q
K
I
-
5
PsiBlast_PDB
68.96
48%
3
- C3 -
-
1O98
1
GPMI_GEOSE
A:
[3-509]
-------
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
E
Y
-
G
V
G
---
E
I
A
T
L
S
G
R
Y
Y
-
S
M
D
R
-
D
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
---
P
T
Y
R
-
D
P
L
E
C
I
E
D
S
Y
K
H
G
I
Y
D
E
F
V
L
P
S
V
I
V
R
EDG
R
P
-----
V
-
A
-----
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
-
G
-
P
-
K
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
V
A
G
Y
V
A
F
K
--
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
V
G
H
S
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
-
P
---------
D
G
K
P
--
Q
T
A
H
T
T
N
P
V
P
-------
V
I
-
V
T
-----
K
K
G
I
---
K
L
R
D
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
----
33
HHSearch
68.93
42%
-21
- C3 -
-
5KGN
1
GPMI_CAEEL
A:
[3-521]
M
A
N
N
S
S
V
A
N
K
V
C
L
I
V
I
D
G
W
G
V
S
E
D
P
Y
G
N
A
I
L
N
A
Q
T
P
V
M
D
K
L
C
S
G
N
-
W
-
A
Q
I
E
A
H
G
L
H
V
G
L
P
-
E
G
L
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
V
I
Y
Q
D
I
V
R
I
N
L
A
V
K
N
N
K
F
V
T
N
E
S
L
V
D
A
C
D
R
A
K
N
G
N
G
R
L
H
L
A
G
L
V
S
D
G
G
V
H
S
H
I
D
H
M
F
A
L
V
K
A
I
K
E
L
G
V
P
E
-
L
Y
L
H
F
Y
G
D
G
R
D
T
S
P
N
S
G
V
G
F
L
E
Q
T
L
E
F
L
E
K
T
T
G
Y
G
---
K
L
A
T
V
V
G
R
Y
Y
-
A
M
D
R
-
D
N
R
W
E
R
I
N
V
A
Y
E
A
M
I
G
G
V
G
--
E
T
S
D
E
A
G
V
V
E
V
V
R
K
R
Y
A
A
D
E
T
D
E
F
L
K
P
I
I
L
-----
Q
G
-----
E
K
G
-----
R
V
Q
N
D
D
T
I
I
F
F
D
Y
R
A
D
R
M
R
E
I
S
A
A
M
G
M
D
R
Y
K
D
C
N
S
-
K
-
L
A
H
-
P
S
N
L
Q
V
Y
G
M
T
Q
Y
K
A
E
F
P
F
K
S
L
F
P
--
P
A
S
N
K
N
V
L
A
E
W
L
A
E
Q
K
V
S
Q
F
H
C
A
E
T
E
K
Y
A
H
V
T
F
F
F
N
G
G
L
E
K
Q
F
E
G
E
E
R
C
L
--
V
P
S
P
K
V
A
T
Y
D
L
Q
P
E
M
S
A
A
G
V
A
D
K
M
I
E
Q
L
E
A
G
T
H
P
F
I
M
C
N
F
A
P
P
D
M
V
G
H
T
G
V
Y
E
A
A
V
K
A
C
E
A
T
D
I
A
I
G
R
I
Y
E
A
T
Q
K
H
G
Y
S
L
M
V
T
A
D
H
G
N
A
E
K
M
K
A
P
D
----------
G
G
K
--
H
T
A
H
T
C
Y
R
V
P
-------
L
T
L
S
H
-----
P
G
F
K
F
V
D
P
A
D
R
H
P
A
L
C
D
V
A
P
T
V
L
A
I
M
G
L
P
Q
P
A
E
M
T
G
V
S
I
V
Q
K
I
-
29
HHSearch
68.61
48%
9
- C3 -
-
4QAX
1
?
A:
[11-512]
-------
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
A
K
F
N
E
L
G
-
I
G
---
Q
F
A
S
V
S
G
R
Y
Y
-
A
M
D
R
-
D
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
--
P
-
T
Y
A
-
T
A
K
E
G
V
E
A
S
Y
N
E
G
L
T
D
E
F
V
V
P
F
I
V
-----
E
N
-----
Q
-
N
D----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
-
E
---
Q
-
V
K
D
L
F
Y
A
T
F
T
K
Y
N
D
N
I
D
A
A
I
V
F
E
--
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
M
V
G
H
S
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
D
----------
D
D
Q
P
--
M
T
T
H
T
T
N
P
V
P
-------
V
I
V
T
K
-----
E
G
V
----
T
L
R
E
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
---
3
PsiBlast_PDB
68.58
48%
3
- C3 -
-
1EJJ
1
GPMI_GEOSE
A:
[3-509]
-------
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
E
Y
-
G
V
G
---
E
I
A
T
L
S
G
R
Y
Y
-
S
M
D
R
-
D
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
---
P
T
Y
R
-
D
P
L
E
C
I
E
D
S
Y
K
H
G
I
Y
D
E
F
V
L
P
S
V
I
V
R
EDG
R
P
-----
V
-
A
-----
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
-
G
-
P
-
K
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
V
A
G
Y
V
A
F
K
--
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
V
G
H
S
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
-
P
---------
D
G
K
P
--
Q
T
A
H
T
T
N
P
V
P
-------
V
I
-
V
T
-----
K
K
G
I
---
K
L
R
D
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
----
4
PsiBlast_PDB
68.56
48%
3
- C3 -
-
1EQJ
1
GPMI_GEOSE
A:
[3-509]
-------
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
E
Y
-
G
V
G
---
E
I
A
T
L
S
G
R
Y
Y
-
S
M
D
R
-
D
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
---
P
T
Y
R
-
D
P
L
E
C
I
E
D
S
Y
K
H
G
I
Y
D
E
F
V
L
P
S
V
I
V
R
EDG
R
P
-----
V
-
A
-----
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
-
G
-
P
-
K
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
V
A
G
Y
V
A
F
K
--
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
V
G
H
S
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
-
P
---------
D
G
K
P
--
Q
T
A
H
T
T
N
P
V
P
-------
V
I
-
V
T
-----
K
K
G
I
---
K
L
R
D
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
----
12
PsiBlast_PDB
68.02
42%
-22
- C3 -
-
5KGL
-
GPMI_CAEEL
A:
[32-536]
-----------
C
L
I
V
I
D
G
W
G
V
S
E
D
P
Y
G
N
A
I
L
N
A
Q
T
P
V
M
D
K
L
C
S
G
N
-
W
-
A
Q
I
E
A
H
G
L
H
V
G
L
P
-
E
G
L
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
V
I
Y
Q
D
I
V
R
I
N
L
A
V
K
N
N
K
F
V
T
N
E
S
L
V
D
A
C
D
R
A
K
N
G
N
G
R
L
H
L
A
G
L
V
S
D
G
G
V
H
S
H
I
D
H
M
F
A
L
V
K
A
I
K
E
L
G
V
P
E
-
L
Y
L
H
F
Y
G
D
G
R
D
T
S
P
N
S
G
V
G
F
L
E
Q
T
L
E
F
L
E
K
T
T
G
Y
G
---
K
L
A
T
V
V
G
R
Y
Y
-
A
M
D
R
-
D
N
R
W
E
R
I
N
V
A
Y
E
A
M
I
G
G
V
G
E
-
T
S
D
E
A
-
G
V
V
E
V
V
R
K
R
Y
A
A
D
E
T
D
E
F
L
K
P
I
I
L
Q----
G
E
-----
K
-
G
-----
R
V
Q
N
D
D
T
I
I
F
F
D
Y
R
A
D
R
M
R
E
I
S
A
A
M
G
M
D
R
Y
K
D
C
N
S
-
K
-
L
-
A
H
P
S
N
L
Q
V
Y
G
M
T
Q
Y
K
A
E
F
P
F
K
S
L
F
P
--
P
A
S
N
K
N
V
L
A
E
W
L
A
E
Q
K
V
S
Q
F
H
C
A
E
T
E
K
Y
A
H
V
T
F
F
F
N
G
G
L
E
K
Q
F
E
G
E
E
R
C
L
--
V
P
S
P
K
V
A
T
Y
D
L
Q
P
E
M
S
A
A
G
V
A
D
K
M
I
E
Q
L
E
A
G
T
H
P
F
I
M
C
N
F
A
P
P
D
M
V
G
H
T
G
V
Y
E
A
A
V
K
A
C
E
A
T
D
I
A
I
G
R
I
Y
E
A
T
Q
K
H
G
Y
S
L
M
V
T
A
D
H
G
N
A
E
K
M
K
A
P
D
---------
G
G
K
---
H
T
A
H
T
C
Y
R
V
P
L
T
L
SHPG
F
K
F
V
D
-----
P
A
D
R
---
H
P
A
----
L
C
D
V
A
P
T
V
L
A
I
M
G
L
P
Q
P
A
E
M
T
G
V
S
I
V
----
11
PsiBlast_PDB
67.79
42%
-22
- C3 -
-
5KGN
1
GPMI_CAEEL
A:
[14-518]
-----------
C
L
I
V
I
D
G
W
G
V
S
E
D
P
Y
G
N
A
I
L
N
A
Q
T
P
V
M
D
K
L
C
S
G
N
-
W
-
A
Q
I
E
A
H
G
L
H
V
G
L
P
-
E
G
L
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
V
I
Y
Q
D
I
V
R
I
N
L
A
V
K
N
N
K
F
V
T
N
E
S
L
V
D
A
C
D
R
A
K
N
G
N
G
R
L
H
L
A
G
L
V
S
D
G
G
V
H
S
H
I
D
H
M
F
A
L
V
K
A
I
K
E
L
G
V
P
E
-
L
Y
L
H
F
Y
G
D
G
R
D
T
S
P
N
S
G
V
G
F
L
E
Q
T
L
E
F
L
E
K
T
T
G
Y
G
---
K
L
A
T
V
V
G
R
Y
Y
-
A
M
D
R
-
D
N
R
W
E
R
I
N
V
A
Y
E
A
M
I
G
G
V
G
E
-
T
S
D
E
A
-
G
V
V
E
V
V
R
K
R
Y
A
A
D
E
T
D
E
F
L
K
P
I
I
L
Q----
G
E
-----
K
-
G
-----
R
V
Q
N
D
D
T
I
I
F
F
D
Y
R
A
D
R
M
R
E
I
S
A
A
M
G
M
D
R
Y
K
D
C
N
S
-
K
-
L
-
A
H
P
S
N
L
Q
V
Y
G
M
T
Q
Y
K
A
E
F
P
F
K
S
L
F
P
--
P
A
S
N
K
N
V
L
A
E
W
L
A
E
Q
K
V
S
Q
F
H
C
A
E
T
E
K
Y
A
H
V
T
F
F
F
N
G
G
L
E
K
Q
F
E
G
E
E
R
C
L
--
V
P
S
P
K
V
A
T
Y
D
L
Q
P
E
M
S
A
A
G
V
A
D
K
M
I
E
Q
L
E
A
G
T
H
P
F
I
M
C
N
F
A
P
P
D
M
V
G
H
T
G
V
Y
E
A
A
V
K
A
C
E
A
T
D
I
A
I
G
R
I
Y
E
A
T
Q
K
H
G
Y
S
L
M
V
T
A
D
H
G
N
A
E
K
M
K
A
P
D
---------
G
G
K
---
H
T
A
H
T
C
Y
R
V
P
L
T
L
SHPG
F
K
F
V
D
-----
P
A
D
R
---
H
P
A
----
L
C
D
V
A
P
T
V
L
A
I
M
G
L
P
Q
P
A
E
M
T
G
V
S
I
V
----
15
PsiBlast_PDB
57.88
32%
22
- C3 -
-
3IGY
1
?
B:
[18-545]
-----------
L
I
V
V
M
D
G
L
G
I
G
P
E
D
D
Y
D
A
V
H
M
A
S
T
P
F
M
D
A
H
R
R
D
N
R
H
F
R
C
V
R
A
H
G
T
A
V
G
L
P
T
D
A
D
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
G
E
I
Y
T
G
E
G
Y
R
Y
L
H
G
A
F
S
K
E
G
S
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
I
Y
S
I
I
E
H
A
V
K
D
G
A
-
K
R
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
G
S
S
F
R
F
T
D
E
L
E
A
V
L
A
K
V
R
Q
N
G
CDA
A
I
A
S
G
G
G
R
M
F
V
T
M
D
R
Y
D
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
G
D
A
RH
F
H
S
A
K
-
E
A
I
T
T
F
R
E
E
D
P
K
V
T
D
Q
Y
Y
P
P
F
I
V
V
-----
D
E
QDKP-
L
-
G
-----
T
I
E
D
G
D
A
V
L
C
V
N
F
R
G
D
R
V
I
E
M
T
R
A
F
E
D
E
D
F
N
K
F
D
R
-
V
-
R
-
V
-
P
K
V
-
R
Y
A
G
M
M
R
Y
D
G
D
L
G
I
P
N
N
F
L
VP
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
I
D
E
K
H
E
T
F
KE
V
P
S
D
R
V
-
Q
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
S
G
M
Y
N
V
V
R
I
N
F
P
N
G
D
M
V
G
H
T
G
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
V
N
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
M
A
Q
R
D
KKGKPMKDG
N
G
N
V
LP
L
T
S
H
T
L
S
P
V
P
--------
V
F
I
G
GAGLD
P
R
V
A
MR-
T
D
L
P
A
A
G
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
Y
E
---------