@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMG9: (2017-11-08 )
MSELKQDQYWMQQAIELAKRGLYSTKPNPNVGCVIVKDNQVIGEGFHPRAGQPHAEVFALRQAGEQAQGATAYVTLEPCAHYGRTPPCAEALVKAQVKKVVVACPDPNPLVAGKGVQILKNAGIEVEIGICEDLAAQLNQGFLKAMSSGMPYVRLKVASSLDGRTAMASGESKWITGSAARQDVQHWRAISGAVITGIETVIADDCQLNVRPLHNVDIETVAQPKRVILDRRGRLPLTAKILENPETVMVMGPYRQELADLGVIQLEIQPLKTLLQTLSKQYQIYDVLIEAGATLSSAFLQEGLIDEMISYVAPTLLGQSARAMFNADFEYMAQQLRFKLLDVTQLDQDIRLRLIPTQEKV
Atome Classification :
(20 SA)
.........10........20........30........40........----50--..--......60--.....-----.-----...70........80........90........100.......110.......120..----.----....130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230......-.240----.-.---.....250.-----..-----..----..260.--...--..----.270--...--......280.......290.......300.......310......--.320..-.....-.330........340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
E
L
K
Q
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
RGLYSTKPNP
N
V
G
C
V
I
V
KDN
Q
V
IGEGFHPR----AG--Q
P
--
H
A
E
V
F
A
L
---
R
QAGE-----Q-----AQG
A
T
A
Y
V
T
L
E
P
C
AHYGRTP
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
ACPDPNPLVAGK
G
V
Q
I
L
K
NAG
I
----
E
----
V
E
I
G
I
C
E
D
L
A
A
Q
L
N
Q
G
F
L
K
A
M
SSGM
P
Y
V
R
L
K
V
ASSLDGRTAMASGES
K
W
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
IS
G
A
V
I
T
G
I
E
T
V
IADD
C
Q
L
N
V
R
PLHNV
D
I
E
TVAQ
P
K
R
V
I
L
DRRGRL
P
L
T
-
A
K
IL----E-N---P
E
T
V
M
V
MG
P
-----
Y
R
-----
Q
E
----
L
ADL
G
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--
I
Q
L
--E
I
----
Q
P
----
L
K
T
--
L
L
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T
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Q
Y
Q
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Y
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V
L
I
EAG
A
T
L
S
S
A
F
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QE
G
L
I
D
E
M
I
S
Y
V
A
P
T
L
L
G
--
Q
S
-
A
R
A
-
M
FNA
D
-
F
E
Y
-
M
A
Q
Q
L
R
F
K
L
L
D
V
T
QLDQD
I
R
L
R
L
IPTQEKV
48
HHSearch
92.57
98%
-108
- C3 -
-
3ZPG
2
?
A:
[23-378]
-
S
E
L
K
Q
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
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----
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--
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A
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V
F
A
L
---
R
Q
A
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-----
Q
-----
A
Q
G
A
T
A
Y
V
T
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E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
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K
V
V
V
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C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
A
G
I
----
E
----
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
--
I
T
G
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A
A
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D
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Q
H
W
R
A
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S
G
A
V
I
T
G
I
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T
V
I
A
D
D
C
Q
L
N
V
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S
L
H
N
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R
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-
A
K
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----
E
-
N
---
P
E
T
V
M
V
M
G
P
-----
Y
R
-----
Q
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----
L
A
D
L
G
V
--
I
Q
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----
Q
P
----
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K
T
--
L
L
Q
T
L
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K
Q
Y
Q
I
Y
D
V
L
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A
G
A
T
L
S
S
A
F
L
Q
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G
L
I
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M
I
S
Y
V
A
P
T
L
L
G
--
Q
S
-
A
R
A
-
M
F
N
A
D
-
F
E
Y
-
M
A
Q
Q
L
R
F
K
L
L
D
V
I
Q
L
D
Q
D
I
R
L
R
L
I
P
T
----
49
HHSearch
92.42
98%
-111
- C3 -
-
3ZPC
-
?
A:
[23-379]
-
S
E
L
K
Q
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
----
A
G
--
Q
P
--
H
A
E
V
F
A
L
---
R
Q
A
G
E
-----
Q
-----
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
A
G
I
----
E
----
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
K
W
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
S
L
H
N
I
D
I
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T
V
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
----
E
-
N
---
P
E
T
V
M
V
M
G
P
-----
Y
R
-----
Q
E
----
L
A
D
L
G
V
--
I
Q
L
--
E
I
----
Q
P
----
L
K
T
--
L
L
Q
T
L
S
K
Q
Y
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
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G
L
I
D
E
M
I
S
Y
V
A
P
T
L
L
G
--
Q
S
-
A
R
A
-
M
F
N
A
D
-
F
E
Y
-
M
A
Q
Q
L
R
F
K
L
L
D
V
I
Q
L
D
Q
D
I
R
L
R
L
I
P
T
Q
---
2
PsiBlast_PDB
92.35
97%
-108
- C3 -
-
3ZPG
2
?
A:
[23-378]
-
S
E
L
K
Q
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
----
A
G
--
Q
P
--
H
A
E
V
F
A
L
---
R
Q
A
G
E
-----
Q
-----
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
A
G
I
----
E
----
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
--
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
S
L
H
N
I
D
I
E
T
V
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
----
E
-
N
---
P
E
T
V
M
V
M
G
P
-----
Y
R
-----
Q
E
----
L
A
D
L
G
V
--
I
Q
L
--
E
I
----
Q
P
----
L
K
T
--
L
L
Q
T
L
S
K
Q
Y
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
E
G
L
I
D
E
M
I
S
Y
V
A
P
T
L
L
G
--
Q
S
-
A
R
A
-
M
F
N
A
D
-
F
E
Y
-
M
A
Q
Q
L
R
F
K
L
L
D
V
I
Q
L
D
Q
D
I
R
L
R
L
I
P
T
----
1
PsiBlast_PDB
92.20
97%
-111
- C3 -
-
3ZPC
-
?
A:
[23-379]
-
S
E
L
K
Q
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
----
A
G
--
Q
P
--
H
A
E
V
F
A
L
---
R
Q
A
G
E
-----
Q
-----
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
A
G
I
----
E
----
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
K
W
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
S
L
H
N
I
D
I
E
T
V
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
----
E
-
N
---
P
E
T
V
M
V
M
G
P
-----
Y
R
-----
Q
E
----
L
A
D
L
G
V
--
I
Q
L
--
E
I
----
Q
P
----
L
K
T
--
L
L
Q
T
L
S
K
Q
Y
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
E
G
L
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D
E
M
I
S
Y
V
A
P
T
L
L
G
--
Q
S
-
A
R
A
-
M
F
N
A
D
-
F
E
Y
-
M
A
Q
Q
L
R
F
K
L
L
D
V
I
Q
L
D
Q
D
I
R
L
R
L
I
P
T
Q
---
51
HHSearch
68.38
42%
-65
- C3 -
-
4G3M
1
RIBD_BACSU
A:
[12-372]
----
S
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
L
P
N
V
-----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QI-
A
P
T
W
I
F
T
T
A
-----
R
A
D
E
E
K
K
K
R
----
L
S
A
F
G
V
--
N
I
F
--
T
L
ETER
I
Q
----
I
P
D
--
V
L
K
I
L
A
E
-
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
-
H
A
P
S
L
I
S
G
E
-
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
K
---
6
PsiBlast_PDB
67.79
42%
-64
- C3 -
-
4G3M
1
RIBD_BACSU
A:
[14-372]
------
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QI
A
P
T
W
I
F
T
T
A
R
-----
A
D
-----
E
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
--
E
T
----
E
R
----
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
H
A
P
S
-
L
I
S
G
E
G
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
K
---
52
HHSearch
67.68
42%
-61
- C3 -
-
2B3Z
-
RIBD_BACSU
A:
[13-371]
-----
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
L
P
N
V
-----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QI-
A
P
T
W
I
F
T
T
A
-----
R
A
D
E
E
K
K
K
R
----
L
S
A
F
G
V
--
N
I
F
--
T
L
ETER
I
Q
----
I
P
D
--
V
L
K
I
L
A
E
-
E
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
-
H
A
P
S
L
I
S
G
E
-
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
30
PsiBlast_CBE
67.61
42%
-64
- C3 -
-
2D5N
1
RIBD_BACSU
B:
[14-371]
------
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QI
A
P
T
W
I
F
T
T
A
R
-----
A
D
-----
E
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
--
E
T
----
E
R
----
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
H
A
P
S
-
L
I
S
G
E
G
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
73
Fugue
67.51
42%
-59
- C3 -
-
2B3Z
-
RIBD_BACSU
A:
[13-371]
-----
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
L
P
N
V
T
K
-----
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
CD--
Q
-
I
---
A
P
T
W
I
F
T
T
A
RAD
E
E
K
K
-----
K
R
----
L
S
A
F
G
V
--
N
I
F
--
T
L
----
E
T
ERIQ
I
P
D
--
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
G
T
H
A
-
P
S
L
-
I
S
G
E
G
-
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
26
PsiBlast_CBE
67.50
42%
-65
- C3 -
-
3EX8
1
RIBD_BACSU
C:
[14-371]
------
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QIA
P
T
W
I
F
T
T
A
R
-----
A
D
-----
E
E
KKKR
L
S
A
F
G
V
NI
F
T
L
--
E
T
----
E
R
----
I
Q
I
PD
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
H
A
P
S
-
L
I
S
G
E
G
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
3
PsiBlast_PDB
67.34
42%
-60
- C3 -
-
2B3Z
-
RIBD_BACSU
A:
[14-371]
------
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QI
A
P
T
W
I
F
T
T
A
R
-----
A
D
-----
E
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
--
E
T
----
E
R
----
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
H
A
P
S
-
L
I
S
G
E
G
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
22
PsiBlast_CBE
67.29
42%
-60
- C3 -
-
4G3M
2
RIBD_BACSU
D:
[14-371]
------
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QIA
P
T
W
I
F
T
T
A
R
-----
A
D
-----
E
E
KKKR
L
S
A
F
G
V
NI
F
T
L
--
E
T
----
E
R
----
I
Q
I
PD
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
H
A
P
S
-
L
I
S
G
E
G
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
23
PsiBlast_CBE
66.82
42%
-64
- C3 -
-
4G3M
2
RIBD_BACSU
C:
[14-371]
------
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QIA
P
T
W
I
F
T
T
A
R
-----
A
D
-----
E
E
KKKR
L
S
A
F
G
V
NI
F
T
L
--
E
T
----
E
R
----
I
Q
I
PD
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
H
A
P
S
-
L
I
S
G
E
G
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
5
PsiBlast_PDB
66.50
42%
-61
- C3 -
-
3EX8
-
RIBD_BACSU
A:
[14-371]
------
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QI
A
P
T
W
I
F
T
T
A
R
-----
A
D
-----
E
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
--
E
T
----
E
R
----
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
H
A
P
S
-
L
I
S
G
E
G
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
4
PsiBlast_PDB
65.97
42%
-62
- C3 -
-
2D5N
-
RIBD_BACSU
A:
[14-371]
------
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QI
A
P
T
W
I
F
T
T
A
R
-----
A
D
-----
E
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
--
E
T
----
E
R
----
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
H
A
P
S
-
L
I
S
G
E
G
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
24
PsiBlast_CBE
65.42
42%
-58
- C3 -
-
4G3M
2
RIBD_BACSU
B:
[14-371]
------
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
--
E
A
--
H
A
E
V
H
A
I
---
H
M
A
G
A
-----
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
----
E
----
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
----
C
-
D
QI
A
P
T
W
I
F
T
T
A
R
-----
A
D
-----
E
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
--
E
T
----
E
R
----
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
--
G
T
H
A
P
S
-
L
I
S
G
E
G
F
Q
S
-
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
----
54
HHSearch
56.61
37%
-8
* C3 *
-
2HXV
9
?
A:
[11-357]
---
H
H
M
Y
E
T
F
M
K
R
A
I
E
L
A
K
K
G
L
G
R
V
N
P
N
P
P
V
G
A
V
V
V
K
D
G
R
I
I
A
E
G
F
H
P
Y
----
F
G
--
G
P
--
H
A
E
R
M
A
I
---
E
S
A
R
K
-----
K
GED--
L
R
G
A
T
L
I
V
T
L
E
P
C
D
H
H
G
K
T
P
P
C
T
D
L
I
I
E
S
G
I
K
T
V
V
I
G
T
R
D
P
N
P
V
-
S
G
N
G
V
E
K
F
R
N
H
G
I
----
E
----
V
I
E
G
V
L
E
E
E
V
K
K
L
C
E
F
F
I
T
Y
V
T
K
K
R
P
F
V
A
L
K
Y
A
S
T
L
D
G
K
I
A
D
H
R
G
D
S
K
W
I
T
D
K
-
L
R
F
K
V
H
E
M
R
N
I
Y
S
A
V
L
V
G
A
G
T
V
L
K
D
N
P
Q
L
T
C
R
L
K
E
G
------
R
N
P
V
R
V
I
L
D
R
K
G
V
L
S
G
K
V
F
R
V
F
----
E
E
N
---
A
R
V
I
V
F
T
E
S
-----
E
E
-----
A
E
-----
Y
P
P
H
V
--
E
K
A
LS
D
-----
C
S
----
V
E
S
--
I
L
R
N
L
Y
E
-
R
D
I
D
S
V
L
V
E
G
G
S
K
V
F
S
E
F
L
D
H
--
A
D
V
V
F
G
F
Y
S
T
K
I
F
G
--
K
G
-
L
-
D
-
V
F
S
G
Y
-
L
S
D
-
V
S
V
P
P
K
F
K
V
V
N
V
E
F
S
D
S
E
F
L
V
E
M
R
P
C
----
7
PsiBlast_PDB
54.13
35%
-3
- C3 -
-
2HXV
9
?
A:
[15-356]
-------
E
T
F
M
K
R
A
I
E
L
A
K
K
G
L
G
R
V
N
P
N
P
P
V
G
A
V
V
V
K
D
G
R
I
I
A
E
G
F
H
P
Y
----
F
G
--
G
P
--
H
A
E
R
M
A
I
E
S
A
R
K
K
G
E
-----
D
-----
L
R
G
A
T
L
I
V
T
L
E
P
C
D
H
H
G
K
T
P
P
C
T
D
L
I
I
E
S
G
I
K
T
V
V
I
G
T
R
D
P
N
P
-
V
S
G
N
G
V
E
K
F
R
N
H
G
I
----
E
----
V
I
E
G
V
L
E
E
E
V
K
K
L
C
E
F
F
I
T
Y
V
T
K
K
R
P
F
V
A
L
K
Y
A
S
T
L
D
G
K
I
A
D
H
R
G
D
S
K
W
I
T
-
D
K
L
R
F
K
V
H
E
M
R
N
I
Y
S
A
V
L
V
G
A
G
T
V
L
K
D
N
P
Q
L
T
C
R
------
L
K
E
G
R
N
P
V
R
V
I
L
D
R
K
G
--
V
L
S
-
G
K
V
F
RVFE
E
-
N
---
A
R
V
I
V
F
T
E
S
-----
E
E
-----
A
E
----
Y
P
P
H
V
E
--
K
A
L
--
S
D
----
C
S
----
V
E
S
--
I
L
R
N
L
Y
E
R
-
D
I
D
S
V
L
V
E
G
G
S
K
V
F
S
E
F
L
D
H
A
--
D
V
V
F
G
F
Y
S
T
K
I
F
G
--
K
G
-
L
-
D
-
V
F
S
G
Y
-
L
S
D
-
V
S
V
P
P
K
F
K
V
V
N
V
E
F
S
D
S
E
F
L
V
E
M
R
P
-----
62
HHSearch
43.86
31%
-59
- C3 -
-
2B3J
2
TADA_STAAM
C:
[4-155]
---
M
T
N
D
I
Y
F
M
T
L
A
I
E
E
A
K
K
A
A
Q
--
L
G
E
V
P
I
G
A
I
I
T
K
D
D
E
V
I
A
R
A
H
N
L
R
ETLQ
Q
P
--
T
A
--
H
A
E
H
I
A
I
---
E
R
A
A
K
-----
V
LGSWR
L
E
G
C
T
L
Y
V
T
L
E
P
C
------
V
M
C
A
G
T
I
V
M
S
R
I
P
R
V
V
Y
G
A
D
D
P
K
G
G
C
S
G
S
L
M
N
L
L
Q
Q
S
N
F
NHRA
I
----
V
D
K
G
V
L
K
E
A
C
S
T
L
L
T
T
F
F
K
N
L
R
A
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
43.62
29%
-61
- C3 -
-
2B3J
2
TADA_STAAM
A:
[4-151]
---
M
T
N
D
I
Y
F
M
T
L
A
I
E
E
A
K
K
A
--
A
Q
L
G
E
V
P
I
G
A
I
I
T
K
D
D
E
V
I
A
R
A
H
N
L
R
----
E
T
LQ
Q
P
TA
H
A
E
H
I
A
I
---
E
R
A
A
K
V
L
GSW
R
-----
L
E
G
C
T
L
Y
V
T
L
E
P
C
V
M
------
C
A
G
T
I
V
M
S
R
I
P
R
V
V
Y
G
A
D
D
P
K
G
G
C
S
G
S
L
M
N
L
L
Q
Q
S
N
F
----
N
H
R
A
I
V
D
K
G
V
L
K
E
A
C
S
T
L
L
T
T
F
F
K
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------