@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMH5: (2017-11-08 )
MLKINDFPHDNNFWKVEWIGGVYNDIDGEPRIRIYLAQIKSNIERQKTLYNSSLEVRNQQNISSVHDVKIGLIQFIPIGSVWKNGILDQSFTAQYEQFNFNSDTPSEVCFQSQYGGIAETGLNNTTEWNNHLNDFHYRIVNSEARALGNYINVFYDYNGLSRIYIPSIVILQACYITSPKSARHIIFGQINKLLDPETSGFIDKETFRIHLHRDYKDIEAPMIANLATNFNAKMGLRTLRQSLVKESNITSISTPKRLKISFPFSNDFSIKVKGKYIMENNKIYGFFVTQIIEFSTKFDFTKLVIFRKNSNQKGKEKAENLQNAYEGCNAVRPSHSESLDDKDESQPLIFTHDQVSNQNLPQSIDFPLCSNISNLEVLKEDKDIQYYQNASYTNLNLRPSNTTSTGPAISSNNGVSELQIEPSLPVDLEYFFDVLEILNKLGYQFKSIAVNNSRDHPRGIINQFNRFIKNLHKWHLQDDDQTPRPFIVAEMIYKGAFYYLLDIAPRKGAALSAQLIRAYTGEQITPTAFAILLNDVARTSPKGWSVLDHAKYSQKWQHFRIEHNRNNKPELVAKNIIKKLG
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.--------.......20........30....---....40.------.---......50.---......----.----60........70----..----------.--------.....80--........-90..--......100-..---......110---.......120.......130....-------...--------140---......--..150.......------160.......-------170-------.......180-----.----..------.----....----.190..---.....200...------------....210-.......220----..--------------...----....230......-.----240--...---------....----.250-------------.........260....---.---..-270-.......--..280-.....----...---.290-.--------....--------.--------..--------------300..-------.....---.310......-.320....----...330---.......340--....------...350----..-----.....360..--..--...-------------370--.....-------...380---------..-.....------..390...--------.--...400....------.-..410...-----...--.420.--...-----------------------..-----.430-..---------.......440..------.-...-------..450.....---..460.....--..-470-..--.....480.......490....------------....500..------...--.-.510----.......520--------........----530--.........-540.-----......------------------..550..-.....560...---------....----570...---------....580---------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------MLKINDFPHDNN--------
F
W
K
V
E
WIG
G
V
Y
NDIDGEP
R
I
R
I
Y
---
L
A
Q
I
K
S
N
------
I
---
E
R
Q
K
T
L
YNS---S
L
E
VRN----Q----QNISSV
H
D
V
K
I
G
----
L
I
----------
Q
--------
F
I
PI
G
S
V
--
W
KNGILDQ-
S
F
T
A
--
Q
Y
E
QFNFN--SD---
T
P
S
E
V
C
F
Q
S---QYGG
I
A
ETGLNNT
T
E
W
NNHLND
F
H
-------
Y
R
I
--------VN----
S
E
A
R
A
L
--G
N
Y
I
N
V
F
Y
DYNG------
L
S
R
I
YI
P
S
I
V
-------
I
L
Q
-------
A
C
YITSPK-------S----A
R
------
H
----
I
I
F
G
----
Q
I
N
K
LL---DPETSG
F
I
DK
E
------------
T
F
R
I
H
L
H-RDYKDIEA------
P
M
--------------
I
A
N
----
L
ATNFN
A
K
M
G
L
R
T
-
L
----
R
Q
---
S
L
V
---------KESN----IT---------------SISTP
K
R
L
K
I
SFPFSN---
D
---
F
S
-
I
---
K
V
K
G
K
Y
I
--
M
EN---N
K
I
Y
G
----
F
F
V
---
T
Q
I
--
I
--------
E
FST--------K--------F
D
--------------
F
-
T
K
L
-------
V
I
F
RK---NSNQK
G
K
E
K
A
-
E
N
L
Q
N
A
Y
E
----
G
C
NAVR---PSHSESLDDK--DESQ------
P
L
I
F
T
H----DQ-----VSNQNLPQSI--DF--PLC-------------SN---ISN
L
E
-------
V
LKE-----------DK-D
I
Q
Y
Y------QNASY
T
N
L
--------
N
--
L
RPSNTTSTG------P-AISSNNG
V
-----
S
E
L
--
Q
IEPS--LP
V
-----------------------
D
L
-----
E
Y
---
F
F
---------
D
V
L
E
I
L
N
K-LGY------
Q
-
F
K
S
-------
I
AVNNSRDH
P
---
R
G
I
I
N
Q
F
N
R
F
--
I
K
-
N
L
H
-
K
W--HLQDDDQTPR
P
F
I
V
A
E
M
-
I
YKG------------
A
F
Y
Y
L
L
DIA------PRK--G-
A
A
L
S
----
A
Q
L
I
R
A
YTG---------EQI
T
P
T
A
F
----
A
----
I
L
L
N
D
V
ART-S--P-----KGW
S
V
L
------------------
D
H
A
K
Y
S
Q
-
K
W
Q
H
F
R
I
EHNR---------NN
K
P
----
E
L
V
A
K
N
---------
I
I
K
KLG----------------------------------------------
13
Fugue
73.79
15%
0
* C9 *
-
5HYW
-
MAX2_ORYSJ
A:
[38-740]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
P
E
P
L
L
--------
L
H
I
L
S
F
L
----
T
D
V
R
S
R
H
R
A
A
L
A
---
C
G
R
M
R
A
A
------
E
---
R
A
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---
R
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P
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----
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----
A
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----------
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--------
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SP
W
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---
C
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---
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-------
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--------
W
H
----
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R
P
P
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L
PD
G
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ALR
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L
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-------
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-------
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L
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T
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-------
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----
T
A
------
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----
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T
------
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L
D
L
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L
---
A
A
A
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------------
L
G
P
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A
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S
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N
L
R
K
L
V
A
------
P
C
L
FNPRFSDCVG
D
D
A
L
L
S
----
L
A
T
S
C
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R
L
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V
L
R
-
L
----
S
E
---
P
F
E
---------
E
E
A
A
----
I
T
----------------
V
A
G
L
V
A
F
F
A
A
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P
A
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---
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---
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A
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----
A
L
A
---
R
R
C
PR
I
--------
K
F
L
T
L
G
SFQGLC
K
--------
A
S
--------------
W
-
L
H
L
DGVAVCG
G
L
E
S
L
---
Y
M
K
N
C
Q
D
L
T
D
-
A
S
L
A
A
I
G
R
----
G
C
---
R
---
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--
D
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------
S
A
G
I
R
R
----
L
A
-----
F
T
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K
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--
T
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--
L
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-------------
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L
---
L
H
T
A
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-------
C
L
T
A
-----------
L
S
-
P
I
S
W
---------
E
M
L
R
S
L
--------
S
--
L
W
F
S
A
G
Q
L
L
S
------
P
-
L
I
S
A
G
L
D
S
-----
C
P
V
--
L
E
E
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--
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K
V
-----------------------
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G
-----
D
T
---
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F
---------
G
L
S
D
L
A
G
F
-
P
V
L
------
A
-
K
M
K
-------
L
D
L
S
E
A
V
D
L
S
L
W
E
R
F
Y
L
H
G
I
E
S
L
QT
L
Y
-
E
L
D
-
Y
W
--
P
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H
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L
T
L
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A
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G
L
I
-
Q
--------------------------------
R
--
C
-
V
G
L
R
----
K
L
F
I
H
G
T
T
H
---------
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H
F
M
T
F
F
L
----
S
----
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P
N
L
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Q
L
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--
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-----
D
Y
Y
P
A
P
-----------------------
A
E
-
S
W
L
R
F
E
V
Q
L
N
S
---------
R
Q
I
D
----
D
------------------------------------------------------------------
21
Fugue
67.94
17%
26
- C8 -
-
2QYU
1
SOPA_SALTY
A:
[8-627]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
S
S
P
S
S
P
A
D
W
---
A
K
K
L
T
D
A
------
V
---
L
R
Q
K
A
--
G
E
---
T
L
T
-
A
A
----
D
----
R
D
F
S
N
A
D
F
R
N
I
T
----
F
S
----------
K
--------
I
L
P
P
S
F
M
--
E
R
D
G
D
I
I
K
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G
F
N
F
--
S
N
S
K
F
T
-
Y
--
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D
----
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S
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L
H
F
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T
L
S
D
V
V
C
S
N
T
K
F
S
N
S
D
M
N
E
V
F
-------
L
Q
Y
---------
S
----
I
T
T
Q
Q
Q
--
P
S
F
I
D
T
T
L
K
N
T
L
------
I
R
H
K
A
N
L
S
G
V
-------
I
L
N
-------
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P
D
N
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-------
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VS
G
G
G
N
------
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----
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L
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D
I
W
L
Q
M
P
L
L
W
T--
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N
A
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F
L
N
H
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HNNGKS
I
L
M
T
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D
S
L
P
D
K
Y
S
-
Q
E
K
V
Q
A
M
E
------
D
L
--------------
V
K
S
----
L
R
G
G
R
L
T
E
A
C
I
R
P
-
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----
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S
---
S
L
V
S
V
LAHPPYT
Q
S
A
L
----
I
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---------------
E
W
L
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P
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Q
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F
A
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C
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---
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A
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---
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----
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L
---
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D
--------
R
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S
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--------
A
--------
M
T
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---------
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-
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-------
I
L
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C
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D
C
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T
R
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A
-
A
A
L
Y
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Y
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----
A
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A
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---
P
H
I
H
N
G
L
F
G
N
--
Y
D
G
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------
P
------------------
D
W
T
T
R
A
A
D
--
N
F
--
L
L
L
-------------
S
S
---
Q
D
S
------------------------
D
T
-
A
M
M
L
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------
T
D
T
L
L
T
M
L
--------
N
--
P
T
P
D
T
A
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L
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-----
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--
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I
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H
-----------------------
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-----
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---
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L
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A
A
F
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Q
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A
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-
Q
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F
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G
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L
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I
D
I
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L
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---
G
E
L
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Q
Q
F
L
A
A
--
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L
I
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D
A
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S
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L
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F
D
P
-
L
L
P
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GKLS
P
A
H
Y
Q
H
I
L
S
A
Y
H
L
T
D
A
T
------
P
Q
K
--
Q
-
A
E
T
L
----
F
C
L
S
T
A
F
A
R
Y
S
SSAIFGT
E
H
D
S
P
P
A
L
----
R
G
Y
A
E
A
L
M
Q
K
A
W
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L
-
S
--
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-----
A
I
F
P
--------------------
S
S
E
Q
F
T
E
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W
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D
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F
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G
L
H
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A
---------
F
T
C
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----
S
V
V
A
D
S
---------
M
Q
R
H
A
R
K
YF
P
S
V
L
S
S
I
LPLAWA------------------------------
20
Fugue
59.08
16%
3
- C9 -
-
3UGM
-
PTHX1_XANOP
A:
[169-1048]
KPKVRELVAHIVALSQHPAALGTVAVTYQHIITALAT
H
E
D
I
V
G
V
G
KQWSG
A
R
A
L
E
A
L
L
T
D
A
G
E
L
RGPPLQLDT
G
Q
L
V
K
I
A
K
R
GG
V
T
A
M
E
A
V
H
A
SRNALTPLNLT
P
A
Q
V
V
A
I
A
SNNG
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
HGLTPA
Q
V
V
A
I
A
SHDG
G
K
Q
A
L
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T
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Q
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L
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P
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L
C
Q
A
H
--------
G
L
P
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Q
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L
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---
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L
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Q
---
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V
A
I
A
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G
K
----
Q
A
L
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R
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L
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V
----
L
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----------
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AHGLT
P
D
Q
V
V
A
I
A
S
----
H
D
G
G
K
Q
A
-
L
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--
Q
R
L
L
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T
P
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Q
V
V
A
I
A
---
S
N
G
G
-
G
K
Q
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R
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L
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V
L
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A
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P
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A
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--------
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K
Q
A
L
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--
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L
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V
L
C
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A
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G
------
L
T
P
D
Q
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A
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A
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G
K
Q
A
L
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-------
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V
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R
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L
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V
-------
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----
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------
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L
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A
----
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V
V
A
I
A
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D
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Q
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Q
------------
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L
L
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L
C
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L
T
P
------
D
Q
--------------
V
V
A
----
I
A
S
N
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G
G
K
Q
A
L
A
T
-
V
----
Q
R
LLP
V
L
C
---------
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A
H
G
----
L
T
PDQV
V
A
I
A
S
N
GGG
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
---
G
---
L
T
-----
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V
V
A
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--
A
S
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GG
G
K
Q
A
L
E
----
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V
Q
---
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L
L
--
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--------
V
L
C
Q
--------
A
--------
H
G
--------------
L
-
T
Q
V
-------
Q
V
V
A
I
---
A
S
N
I
G
G
K
Q
A
L
-
E
T
V
Q
R
L
L
P
----
V
L
C
Q
A
H
G
L
T
P
A
Q
V
V
A
I
A
S
H
--
D
G
G
K
------
Q
A
L
E
T
V
----
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
D
Q
--
V
V
--
A
I
A
-------------
S
N
GG
G
K
Q
A
L
E
-------
T
V
Q
R
LLPGLT-----
Q
E
-
Q
V
V
A
I
A
SNNGG
K
Q
A
L
E
T
V
Q
--------
R
--
L
L
P
V
L
C
Q
A
H
G
LT
P
D
Q
V
V
-
A
I
A
S
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G
G
G
-----
K
Q
A
L
E
T
V
Q
R
L
--
L
P
V
LCQAHGLT
P
A
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V
A
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A
SNIG
G
K
Q
A
L
-----
E
T
---
V
Q
---------
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L
L
P
V
L
C
Q
D
H
G
L
------
T
-
L
A
Q
-------
V
V
A
I
A
S
N
I
G
G
---
K
Q
A
L
E
T
V
Q
R
L
--
L
P
-
V
L
C
-
Q
G
--
L
T
Q
D
Q
V
V
A
I
A
S
N
I
G
G
K
Q
-
A
L
E
T
------------
V
Q
R
L
L
P
V
L
C
------
Q
D
H
--
G
---
L
T
----
P
D
Q
V
V
A
I
A
S
---------
N
I
G
G
K
Q
A
L
----
E
----
T
V
Q
R
L
L
P
V
L
C
Q
--
D
-----
H
G
L
T
L
D
------------------
Q
V
V
A
I
A
S
-
N
G
G
K
Q
A
L
E
T
V
Q
---------
R
L
L
P
----
V
L
C
Q
D
H
GLTPDQVVA
I
A
S
N
S
G
----------------------------------------------
22
Fugue
49.87
11%
31
- C5 -
-
4HG6
3
?
B:
[36-702]
--------------------------------------------------------------------------------------------------------------------------------------------------------P
W
I
I
P
L
R
P
L
A
E
T
A
Q
V
G
P
--------
L
F
R
L
Q
G
Q
-------
Q
A
R
A
A
F
R
L
F
---
L
P
T
E
A
V
G
------
G
---
T
L
T
L
A
Q
R
S
S
I--
D
I
L
P
E
S
----
S
----
Q
I
I
V
R
M
N
D
Q
E
I
G
----
R
F
T
P
RQFGA
L
G
A
V
--------
T
M
P
L
G
E
A
--
V
R
A
G
D
N
L
V
-
T
I
E
A
--
Q
H
-
R
H
R
I
Y
--
C
G
---
A
D
A
E
F
D
L
W
T
---
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D
-
L
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A
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G
T
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F
-------
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A
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--------
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----
A
Q
A
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S
G
--
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P
V
E
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R
T
P
T
P
P
D
------
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A
T
L
R
T
L
A
Q
A
-------
L
G
R
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L
PDEAL
P
L
A
L
S
K
P
W
-------
S
----
A
E
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A
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----
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T
L
L
----
P
S
D
A
D
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---
V
S
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R
R
G
G
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G
A
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------------
V
L
V
L
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P
-
P
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-
G
S
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N
A
------
S
L
--------------
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A
D
----
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L
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A
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T
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P
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L
-
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----
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I
---
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P
G
---------
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V
V
T
----
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A
---------------
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M
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V
D
T
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L
T
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N
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Y
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---
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---
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G
--
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A
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A
L
L
L
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--------
K
--------
V
N
--------------
G
-
T
T
V
-------
R
M
L
P
L
---
D
R
D
A
A
P
V
K
P
R
-
L
D
I
R
F
P
A
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G
P
N
R
L
S
---
F
E
S
V
I
P
G
N
P
P
--
D
Q
P
C
------
P
A
S
A
G
D
----
L
M
-----
Q
V
L
S
S
T
--
D
L
--
E
V
--
P
P
S
-------------
P
R
---
M
Q
M
A
D
-------
M
A
R
D
L
A
Q
VT------
P
A
-
S
V
H
P
A
------
T
P
D
G
L
A
R
T
--------
L
--
P
F
M
A
A
F
R
E
V
P
------
D
-
A
A
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V
D
L
T
V
-----
A
G
L
--
H
D
I
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--
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P
L
-----------------------
N
E
-----
E
G
---
L
T
---------
P
R
L
L
A
L
T
L
-
L
P
S
------
T
-
G
P
P
A
N
A
LAPL
G
A
A
P
G
E
G
V
M
P
---
P
L
V
E
S
N
W
S
D
R
--
A
Q
-
T
F
V
-
Q
A
--
T
L
Q
P
V
I
Q
T
-----
V
R
R
M
-
L
R
P
G
------------
D
G
N
L
A
E
W
L
A
------
T
R
K
--
G
-
T
A
M
L
L
A
P
E
P
G
K
L
W
V
I
L
G
---------
P
E
A
E
P
A
R
V
----
A
----
E
A
L
A
M
A
P
R
S
-
P
GG
P
-----
R
G
Q
V
A
V
LGSDG
R
W
S
S
W
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PG
L
L
P
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L
R
E
P
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S
L
-
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V
G
N
V
A
---------
S
A
R
P
----
P
L
L
L
G
G
---------
M
L
G
L
A
W
I
S
A
A
I
A
V
G
F
V
L
R
TR--------------------------------
19
Fugue
48.89
17%
34
- C4 -
-
4YJ1
1
?
A:
[1-615]
-----------------------------------------------------------------------------------------------------------------------------------------------------------GF
S
P
L
M
D
F
F
H
S
V
E
G
--------
R
N
Y
G
E
L
R
S
L
T
N
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T
Y
Q
I
S
E
N
V
R
C
T
---
F
L
S
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D
PFAP
G
S
Q
---
V
R
L
V
C
P
C
T
F
---
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L
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K
V
L
----
Q
TTDL
A
A
A
N
P
C
R
R
V
A
A
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----
D
F
----------
I
--------
L
R
S
F
H
A
G
--
Y
R
N
G
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P
R
R
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G
A
V
--
Q
V
L
R
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--
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---
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L
V
K
---
A
H
Q
--
A
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F
A
R
V
K
L
P
G
H
-------------------------------------
G
R
R
I
D
---
G
H
G
A
------
I
D
I
F
Y
N
E
L
V
P
-------
L
L
E
-------
Q
C
V
V
G
L
N
E
-------
E
----
D
L
------
H
Q
H
V
I
C
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D
----
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E
V
L
R
S
---
N
L
L
G
A
G
Y
V
A
F
V
------------
A
N
G
A
I
L
P
-
R
D
A
G
N
S
D
K
------
P
L
--------------
R
D
N
-----
A
V
P
F
Q
S
P
K
S
L
E
C
-
S
----
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T
---
L
P
H
---------
S
G
K
T
----
I
T
---------------
G
M
G
L
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L
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G
G
F
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---
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---
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--------
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T
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--------
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--------
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F
-
I
N
N
-------
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---
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A
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---
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G
S
Q
L
L
L
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--
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A
------
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N
L
M
Y
R
----
D
A
-----
L
M
Q
M
L
V
P
R
A
Q
--
E
P
IT
P
F
V
-------------
E
R
---
V
A
D
L
S
QNHG
V
S
S
I
M
V
I
-----------
G
G
-
S
G
Q
Y
F
------
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Q
A
R
V
V
L
V
--------
M
N
A
Y
Q
I
S
D
C
T
K
E
A
------
K
-
E
I
A
S
N
S
S
L
PGDTA
S
V
F
--
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--
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C
F
-----------------------
D
P
-----
D
G
---
S
F
---------
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T
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R
R
G
T
K
-
V
S
G
I
GTESI
R
-
F
S
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-------
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T
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D
L
S
M
V
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Q
---
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V
E
E
G
Q
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-
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L
A
-
L
L
--
Y
D
G
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------
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P
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M
-
T
T
K
G
------------
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A
---
L
T
Q
L
------
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S
P
--
G
-
G
V
C
E
----
I
Q
-
R
G
K
F
N
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---------
N
F
S
S
M
I
A
G
----
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----
C
S
H
Q
H
D
K
R
L
-
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--
L
-----
R
T
P
S
C
Y
------------------
L
P
R
G
F
T
S
-
A
T
R
H
I
E
I
G
A
A
L
---------
N
R
L
R
----
T
L
R
T
V
T
-------------------------------------------------------------
16
Fugue
48.80
15%
59
- C6 -
-
4ZUZ
-
?
A:
[8-864]
-------D
V
I
K
F
K
EPERCDY
L
Y
V
D
ENN
K
V
H
I
L
L
P
IVGGDE
I
G
L
D
N
TC
Q
T
A
V
E
L
I
T
F
F
YGSAHSGVTKYS
A
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K
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A
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Q
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D
D
L
L
K
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K
I
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L
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Q
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L
I
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L
K
K
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TGGIPQLP
S
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A
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L
F
N
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K
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D
T
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A
P
I
P
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EG
L
G
Y
R
L
R
S
T
------
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D
K
T
P
T
P
I
N
K
K
S
L
R
D
K
V
K
S
----
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----
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L
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K
D
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D
R
I
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K
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----------
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--------
L
N
E
L
I
T
N
--
L
Q
N
E
L
V
K
E
-
L
V
K
S
DP
Q
Y
S
K
L
S
L
S
--
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----
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K
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---
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Y
L
V
N
S
L
M
L
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D
N
D
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G
D
W
I
D
T
I
L
-------
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A
T
--------
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D
----
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T
V
W
A
V
--
Q
A
S
S
P
F
Y
Q
G
A
K
E
------
I
S
S
D
R
D
A
D
K
I
-------
S
I
R
-------
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Q
Y
L
L
---------------
A
E
------
A
----
N
I
Y
C
----
K
T
N
K
L
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---
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A
N
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F
F
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------------
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A
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F
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I
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P
I
--------------
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D
----
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A
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L
G
L
K
S
P
L
----
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---
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---------
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----
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---------------
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---
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F
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---
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D
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F
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---
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Q
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--
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--------
G
K
H
P
--------
L
--------
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D
--------------
L
A
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-------
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A
L
Q
E
---
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T
S
N
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L
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H
K
N
-
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V
A
Q
G
Y
E
----
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L
D
Q
F
K
---
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L
L
A
E
N
--
K
P
K
E
------
L
L
D
Y
L
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----
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T
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P
N
Y
S
M
L
S
K
E
T
--
Q
N
--
Y
I
A
-------------
Y
N
---
R
N
W
P
A
-------
I
Q
K
E
L
E
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ATSIP
E
S
Q
K
Q
-
D
L
S
R
L
LSR---
D
N
L
Q
H
D
N
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--------
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--
A
I
T
W
S
K
Y
S
S
K
------
P
-
L
L
D
V
E
L
N
K
-----
I
A
E
--
G
L
E
L
T
--
A
K
I
-----------------------
Y
N
E
K
RGR
E
W
---
W
F
AGSR
N
E
A
R
K
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Q
C
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L
Q
R
-
V
S
K
------
E
-
I
N
T
-------
L
L
Q
S
E
S
L
T
K
S
---
Q
-
V
L
E
K
V
L
N
S
--
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E
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T
L
D
-
K
I
D
R
D
I
S
A
E
S
N
W
F
Q
S
T
L
Q
K
E
V
R
L
F
R
D
------------
Q
L
K
D
I
C
Q
L
D
K
Y
Y
F
K
S
T
K
L
--
D
-
E
I
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----
L
E
M
E
E
Q
F
Q
-----------
K
I
Q
D
P
A
V
----
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----
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R
D
L
P
S
H
-
C
--
H
N
D
E
A
I
E
F
F
K
T
L
------------------
N
P
E
E
A
A
K
-
V
A
S
Y
L
S
L
E
Y
R
E
---------
I
N
K
S
TDK
K
T
L
L
E
Q
D
---------
I
P
R
L
F
K
E
V
N
T
Q
L
L
S
K
L
K
E
E
KAID
E
Q
V
H
E
K
L
S
Q
L
ADKIAPEHFT
R
N
N
I
I
K
W
S
T
17
Fugue
44.19
12%
38
* C8 *
-
1JMU
2
?
B:
[1-633]
--------------------------------------------------------------------------------------------------------------------------------------------------------PG
G
V
P
W
I
A
I
G
D
E
T
S
V
T
S
--------
P
G
A
L
R
R
M
----
T
S
K
D
I
D
E
P
L
V
V
V
---
T
E
H
A
I
A
N
------
F
---
T
K
A
E
M
A
L
E
F
---
N
R
E
F
L
D
----
K
----
L
R
V
L
S
V
---
S
P
K
----
Y
S
----------
D
--------
L
L
T
Y
V
D
C
--
Y
V
G
V
S
A
R
Q
-
A
L
N
N
--
F
Q
K
Q
V
P
V
I
--
T
--------
P
T
R
Q
T
---
M
Y
V
D
S
I
Q
A
A
L
K
A
L
E
K
W
E
I
D
L
R
V
A
Q
-------
T
L
L
PTNVP
I
G
E
V
S
----
C
P
M
Q
S
V
--
V
K
L
L
D
D
Q
L
P
D
D
S
------
L
I
R
R
Y
P
K
E
A
A
-------
V
A
L
-------
A
K
R
N
G
G
I
Q
W
M
DVSEG
T
----
V
M
------
N
----
E
A
V
N
----
A
V
A
A
S
A
L
AP
S
A
S
A
P
P
L
E
E
K
S
------------
K
L
T
E
Q
A
M
-
D
L
V
T
A
A
E
P
------
E
I
--------------
I
A
S
LVPV
P
A
P
V
F
A
I
P
P
K
P
A
D
-
Y
----
N
V
---
R
T
L
---------
K
I
D
E
----
A
T
---------------
W
L
R
M
-----
I
P
K
T
M
G
T
---
L
---
F
Q
-
I
---
Q
V
T
D
N
------
T
---
G
T
N
W
H
----
F
N
L
R
GG
T
R
V
--
V
--------
N
L
D
-------------------
Q
--------------
I
-
A
P
M
-------
R
F
V
L
D
---
L
G
G
K
S
Y
K
E
T
S
-
W
D
P
N
G
K
K
V
----
G
F
I
V
F
Q
S
--
K
I
P
F
E
L
W
T
A
A
--
S
Q
I
G
------
Q
A
T
V
V
N
----
Y
V
Q
L
Y
A
-
E
D
S
S
F
T
A
Q
S
I
I
A
T
T
--
S
L
A
-------------
Y
N
---
Y
E
P
E
Q
-------
L
N
K
T
-----------
D
P
-
E
M
N
Y
Y
------
L
L
A
T
F
I
D
S
--------
A
--
A
I
T
P
T
N
M
T
Q
P
------
D
-
V
W
D
A
----------
L
L
--
T
M
S
P
L
--
S
A
G
-----------------------
E
V
-----
T
V
KGA
V
V
---------
S
E
V
V
P
A
E
L
-
I
G
S
------
Y
T
P
E
S
-------
L
N
A
S
L
P
N
D
A
A
---
R
C
M
I
D
R
A
S
K
I
--
A
E
-
A
I
K
-
I
D
DD
A
G
P
D
E
Y
S
P
N
S
V
P
I
Q
G
Q
L
-
A
I
S
Q
------------
L
E
T
G
Y
G
V
R
I
------
F
N
P
--
K
-
G
I
L
S
----
K
I
A
S
R
A
M
Q
A
---------
F
I
G
D
P
S
T
I
ITQA
A
----
P
V
L
S
D
K
N
N
W
-
I
--
A
-----
L
A
Q
G
V
K
------------------
T
S
L
R
T
K
S
-
L
S
A
G
V
K
T
A
V
S
K
---------
L
S
S
S
----
E
S
I
Q
N
W
---------
T
Q
G
F
L
D
K
V
S
T
H
F
PAP-------------------------------------
5
HHSearch
41.37
17%
-14
- C11 -
-
5D16
1
TNSE_ECOLX
A:
[39-196]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
N
Y
N
S
I
--
F
A
N
-----------------------
R
F
-----
A
A
---
F
D
---------
E
L
L
S
I
L
K
T
-
K
-----------
F
A
-------
C
R
V
L
F
------------
E
E
T
L
V
L
--
P
K
V
G
R
S
-
R
L
--
H
L
C
K
D
-
G
S
P
R
V
I
K
A
V
G
V
-
Q
R
N
G
------------
S
E
F
V
L
L
E
V
D
------
V
S
D
--
G
V
K
M
L
S
----
T
K
V
L
S
G
V
D
S
---------
E
T
W
R
N
-
D
F
----
E
----
K
I
R
R
G
V
V
K
S
-
S
--------
L
N
W
P
N
S
------------------
L
F
D
Q
-
L
Y
G
Q
D
G
H
R
G
V
N
H
P
K
GLGELQVS
R
E
N
M
E
----
G
W
A
E
R
V
---------
V
R
E
Q
F
-----------------------------------------------
4
HHSearch
40.63
17%
-11
* C11 *
-
5D16
-
B:
[39-193]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
N
Y
N
S
I
--
F
A
N
-----------------------
R
F
-----
A
A
---
F
D
---------
E
L
L
S
I
L
K
T
-
K
-----------
F
A
-------
C
R
V
L
F
------------
E
E
T
L
V
L
--
P
K
V
G
R
S
-
R
L
--
H
L
C
K
D
-
G
S
P
R
V
I
K
A
V
G
V
-
Q
R
N
G
------------
S
E
F
V
L
L
E
V
D
------
V
S
D
--
G
V
K
M
L
S
----
T
K
V
L
S
G
V
D
S
---------
E
T
W
R
N
-
D
F
----
E
----
K
I
R
R
G
V
V
K
S
-
S
--------
L
N
W
P
N
S
------------------
L
F
D
Q
-
L
Y
G
Q
D
G
H
R
G
V
N
H
P
K
GLGELQVSR
E
N
M
E
----
G
W
A
E
R
V
---------
V
R
--------------------------------------------------
2
PsiBlast_PDB
37.78
25%
-56
- C10 -
-
3UDT
2
IPPK_ARATH
A:
[333-469]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----
V
L
D
R
L
L
---
E
I
Q
K
L
D
K
L
D
I
E
------------
G
-
A
I
H
C
Y
-
Y
D
I
I
N
Q
P
C
------
P
---------------
I
C
--------------
S
L
H
A
-
L
P
L
D
E
S
L
---
K
I
V
---------
K
E
Y
L
----
I
A
---------------
A
T
A
K
D
C
S
I
M
I
S
F
Q
S
-------------------
G
D
Y
V
S--
P
T
---
N
Q
T
F
D
----
Y
K
V
----
H
F
--
I
--------
D
L
S
L
--------
K
PLKR
M
E
S
Y
Y
K
--------------
L
-
D
K
K
-------
I
I
S
F
Y
---
N
R
K
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
34.24
13%
31
- C2 -
-
5IG8
-
?
A:
[5-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
--------------
V
V
L
----
L
L
T
H
S
G
D
F
F
T
I
D
R
-
V
----
A
E
---
A
I
E
---------
K
K
G
A
T
P
F
R
L
D
---------------
T
D
K
F
P
L
E
V
Q
L
T
A
Q
F
N
G
---
K
KS
F
Y
Q
-
L
---
S
Y
N
H
Q
S
I
--
D
S
E
---
Q
-
V
Q
S
----
V
W
T
---
R
R
I
W
Q
P
--------
E
L
T
G
--------
D
--------
L
D
--------------
P
-
Q
F
R
-------
E
V
C
V
R
---
E
S
Q
T
T
L
A
G
F
W
-
D
S
L
R
S
A
R
W
LD--
N
L
A
Q
I
E
---
K
A
K
N
K
L
L
Q
L
R
--
L
A
S
E
V
G
L
I
I
P
P
T
L
V
T
N
----
N
P
-----
D
A
A
R
E
F
F
S
Q
V
--
Q
G
--
R
M
V
-------------
S
K
---
L
L
T
A
I
-------
A
R
S
M
-----------
E
S
-
P
E
F
F
L
------
Y
T
S
R
V
K
A
E
--------
D
--
L
E
E
A
E
S
L
R
Y
C
------
P
----------------
M
--
V
F
Q
A
E
--
I
P
K
-----------------------
Q
L
-----
E
L
---
R
V
---------
V
V
V
N
G
Q
T
F
-
V
G
A
------
L
-
E
S
S
-------
Q
G
A
W
Q
H
H
T
L
P
---
D
S
L
L
Q
Q
L
Q
I
F
--
M
A
-
N
L
G
L
N
F
--
G
A
F
D
F
I
L
T
P
G
G
E
Y
V
F
L
E
-
V
N
P
G
------------
G
E
W
G
M
L
E
R
D
------
L
D
L
P
I
S
-
Q
A
I
A
----
D
F
L
V
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
34.07
13%
-28
- C3 -
-
4WPC
1
RGD1_YEAST
A:
[14-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
T
P
E
I
---
K
K
V
L
N
S
D
V
A
I
N
------------
A
L
L
S
R
L
K
-
Q
S
L
L
T
C
E
E
------
F
M
--------------
K
F
I
----
R
K
K
Y
A
F
E
E
E
H
V
Q
E
-
L
----
S
K
---
Q
Y
K
---------
H
F
F
N
----
I
Q
---------------
N
S
S
L
K
K
M
I
H
E
V
L
G
F
D
G
---
K
---
M
A
-----
Q
V
K
Q
S
Y
I
--
T
A
L
---
Q
K
M
Y
S
----
E
I
S
---
S
L
L
--
L
--------
T
M
T
K
-----------------------------------------------
L
R
K
---
S
V
K
E
N
S
K
R
L
E
-
K
D
V
S
D
A
I
H
----
S
A
E
K
A
Q
---
S
R
Y
N
S
L
C
Q
D
W
--
D
K
L
R
------
K
T
K
L
T
L
----
R
G
------
S
K
T
T
K
E
Q
E
E
--
E
L
--
L
R
K
-------------
I
D
---
N
A
D
L
E
-------
Y
K
Q
K
-----------
V
D
-
H
S
N
S
L
------
R
N
T
F
I
T
K
------------
E
R
P
R
I
V
Q
E
L
K
------
D
-
L
I
L
E
I
D
T
A
-----
M
T
I
--
Q
L
Q
K
Y
--
T
I
W
-----------------------
T
E
-----
N
L
---
V
L
---------
N
T
G
V
T
I
S
P
-
L
D
S
------
T
-
K
S
M
-------
K
S
F
A
G
S
V
S
N
E
---
R
D
L
Y
S
F
L
N
K
Y
--
N
Q
-
L
I
N
-
K
---
N
L
I
P
V
S
Y
K
K
H
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
33.51
29%
4
- C10 -
-
5B04
-
EI2BD_SCHPO
G:
[114-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IF
E
E
K
Q
------
V
S
I
F
S
H
LDWR
R
R
-----
R
T
T
E
N
I
P
K
D
I
--
H
P
--
A
V
I
RLGLKLANYKIFG
S
N
---
Q
R
C
I
D
-------
L
L
K
T
-----------
F
K
I
V
I
Q
D
Y
------
Q
T
P
Y
G
T
T
L
SRHLTTHI
N
--
S
Q
I
A
Y
L
V
S
T
R
------
P
L
S
I
S
M
G
N
A
I
-----
R
F
L
--
K
L
E
I
S
V-
L
D
I
-----------------------
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
33.17
25%
-29
- C10 -
-
4LV7
2
IPPK_ARATH
A:
[333-471]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----
V
L
D
R
L
L
---
E
I
Q
K
L
D
K
L
D
I
E
------------
G
-
A
I
H
C
Y
-
Y
D
I
I
N
Q
P
C
------
P
---------------
I
C
--------------
S
L
H
A
-
L
P
L
D
E
S
L
---
K
I
V
---------
K
E
Y
L
----
I
A
---------------
A
T
A
K
D
C
S
I
M
I
S
F
Q
----------------------
Y
V
S
L
K
P
T
---
N
Q
T
F
D
----
Y
K
V
----
H
F
--
I
--------
D
L
S
L
--------
K
P
LKR
M
E
S
Y
Y
K
--------------
L
-
D
K
K
-------
I
I
S
F
Y
---
N
R
K
Q
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
29.22
10%
-78
- C7 -
-
2RGF
-
A:
[56-86]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
--
D
Y
E
L
L
Q
I
L
S
-
D
D
-------
R
K
L
K
I
P
E
N
---------
A
N
-------
V
F
Y
A
M
N
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
25.00
8%
-
- C11 -
-
5CQC
-
?
A:
[129-165]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
T
F
I
L
P
F
V
E
-------
M
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
22.62
25%
-30
- C12 -
-
3GN6
1
?
B:
[255-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
E
-------
I
L
R
-------
N
A
H
A
D
G
G
--------
L
----
R
A
------
Y
----
I
M
H
G
----
V
W
E
S
V
W
---
D
H
E
N
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
21.79
9%
-
- C1 -
-
5MS2
-
?
A:
[159-169]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
F
I
L
P
F
V
E
-------
M
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
21.17
25%
-26
* C12 *
-
3GN6
3
?
C:
[255-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
E
-------
I
L
R
-------
N
A
H
A
D
G
G
--------
L
----
R
A
------
Y
----
I
M
H
G
----
V
W
E
S
V
W
---
D
H
E
N
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
6.11
21%
116
* C10 *
-
5LZ6
-
?
B:
[18-31]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
V
---
L
E
I
--
L
--------
S
K
S
K
--------
P
--------
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------