@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMK1: (2017-11-08 )
MRLKIAKESLLNVLSHVVGAVERRHTLNILSNVKIQTNAQALTITGSDLEVELVASTALSEGACLEAGETTVPARKLMEICKSLPTAALIDLQITEDQRCILKSGNSRFVLGTLPAEDYPLLTTENSQGTQVQVTQRELKRLFEKTAFAMAVQDVRFYLTGTLLEIDENQLRAVTTDGHRLALCEILASSTSSQLVQAIVPRKAVGELQRLLSIEDEQLTLLIGRELLNVTINTPSRDKEQGDITVRFTTKLIDGKFPDYRRVIPRGGDKHVLIGHDVFKQSLQRVAILSNEKLRGVFLNFNQDSLQLRANNPEQDEAIEDLAIQYQNAPLEMSFNAQYLLDVLGVLDGDDVNMSMTEANQSVLVQDPAHPDQTYVVMPMRV
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130........140.......150.......160.......170.......180....-...190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRLK
I
A
K
E
S
L
L
N
V
L
S
H
V
V
G
A
V
E
R
R
H
T
L
N
I
L
SN
V
K
I
Q
TNA
Q
A
L
T
I
TGSD
L
E
V
E
L
V
A
STALSEGACLEAGETTV
P
A
R
K
L
M
E
I
C
K
SLPT
A
A
L
I
D
L
Q
ITEDQ
R
C
I
LKSGN
S
R
F
V
L
G
TLPAED
Y
P
L
L
TTENSQG
T
-
Q
V
Q
V
T
Q
R
E
L
K
R
L
F
E
K
T
A
F
A
M
A
V
Q
D
V
R
F
Y
L
T
G
T
L
L
E
IDENQ
L
R
A
VTTDG
H
R
L
A
L
C
E
I
-
L
A
SS
T
S
S
Q
L
V
Q
A
IV
P
R
K
A
V
G
E
L
Q
R
L
L
SIED
E
Q
L
T
L
L
I
G
R
E
L
L
N
V
T
INTPSRDKEQG
D
I
T
V
R
F
T
T
K
LIDGKFP
D
Y
R
R
VIPRGGDK
H
V
L
I
G
H
D
V
F
K
Q
S
L
Q
R
V
A
ILSNE
K
L
R
G
V
F
L
NFNQD
S
L
Q
L
RANNP
E
Q
D
E
A
I
E
D
L
A
I
QYQNAP
L
E
M
SF
N
A
Q
Y
L
L
D
V
L
G
VLDGDDVN
M
S
MTEAN
Q
S
V
L
VQDPAHPD
Q
T
Y
V
V
M
P
MRV
95
HHSearch
90.32
46%
-127
- C4 -
-
4K3L
8
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
--
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
-
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
-
S
E
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
-
P
I
G
Q
-
S
L
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
-----------
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
96
HHSearch
89.45
46%
-120
- C4 -
-
3BEP
2
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
--
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
-
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
-
S
E
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
-
P
I
G
Q
-
S
L
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
-----------
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
100
HHSearch
89.35
48%
-129
- C4 -
-
4TR8
-
?
B:
[17-383]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
---
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
--
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
-
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
----
G
P
-
G
S
L
-
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
-
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
-----------
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
1
PsiBlast_PDB
88.16
47%
0
- C- -
-
4TSZ
-
?
H:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
--
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
-
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
--
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
-
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
---------
G
E
F
T
--
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
94
HHSearch
87.87
48%
0
- C- -
-
4TSZ
-
?
G:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
--
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
-
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
-
G
S
L
-
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
-
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
-----------
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
45
PsiBlast_CBE
87.24
45%
-48
- C4 -
-
4OVG
5
?
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
88
PsiBlast_CBE
86.86
45%
-46
- C4 -
-
3D1G
1
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
50
PsiBlast_CBE
86.66
45%
-52
- C4 -
-
4N9A
4
DPO3B_ECOLI
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
--------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
8
PsiBlast_PDB
86.65
45%
-45
- C4 -
-
1UNN
-
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
90
PsiBlast_CBE
86.55
45%
-47
- C4 -
-
3BEP
3
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
15
PsiBlast_PDB
86.53
45%
-53
- C4 -
-
3Q4K
-
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
-------
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
--
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
16
PsiBlast_PDB
86.52
45%
-49
- C4 -
-
4K3K
5
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
--------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
5
PsiBlast_PDB
86.44
45%
-51
- C4 -
-
3Q4L
-
DPO3B_ECOLI
A:
[3-368]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
65
PsiBlast_CBE
86.40
45%
-51
- C4 -
-
4MJQ
5
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
----
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
37
PsiBlast_CBE
86.26
45%
-50
- C4 -
-
4PNW
4
?
B:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
39
PsiBlast_CBE
86.25
45%
-47
- C4 -
-
4PNV
2
?
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
80
PsiBlast_CBE
86.24
45%
-49
- C4 -
-
4K3K
2
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
4
PsiBlast_PDB
86.22
45%
-49
- C4 -
-
3QSB
1
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
38
PsiBlast_CBE
86.21
45%
-51
- C4 -
-
4PNW
1
?
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
14
PsiBlast_PDB
86.16
45%
-47
- C4 -
-
3Q4J
-
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
55
PsiBlast_CBE
85.99
45%
-51
- C4 -
-
4N97
5
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
44
PsiBlast_CBE
85.89
45%
-52
- C4 -
-
4OVH
6
?
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
--
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
46
PsiBlast_CBE
85.68
45%
-49
- C4 -
-
4OVG
5
?
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
-----
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
48
PsiBlast_CBE
85.60
45%
-50
- C4 -
-
4OVF
5
?
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
53
PsiBlast_CBE
85.43
45%
-51
- C4 -
-
4N98
2
DPO3B_ECOLI
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
------
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
66
PsiBlast_CBE
85.17
45%
-49
- C4 -
-
4MJP
4
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
-------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
63
PsiBlast_CBE
85.14
45%
-49
- C4 -
-
4MJR
3
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
47
PsiBlast_CBE
85.11
45%
-48
- C4 -
-
4OVF
4
?
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
--------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
81
PsiBlast_CBE
85.05
45%
-45
- C4 -
-
3QSB
1
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
13
PsiBlast_PDB
84.78
45%
-47
- C4 -
-
3D1G
1
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
79
PsiBlast_CBE
84.41
45%
-49
- C4 -
-
4K3L
8
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
41
PsiBlast_CBE
84.14
45%
-51
- C4 -
-
4PNU
3
?
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
57
PsiBlast_CBE
83.94
45%
-51
- C4 -
-
4N96
3
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
---------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
-
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
42
PsiBlast_CBE
83.74
45%
-52
- C4 -
-
4PNU
5
?
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
-----
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
61
PsiBlast_CBE
83.45
45%
-43
- C4 -
-
4N94
2
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
-
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
17
PsiBlast_PDB
83.06
45%
-48
- C4 -
-
4K3L
5
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
---------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
--
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
-
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
-
V
-
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
S
V
--
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
---
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
---------
G
D
F
I
--
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-