@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMK6: (2017-11-08 )
MIQFDQVSLRRGGRVLFQKASMQLHPGWKIGLTGVNGAGKSTLFAALLGSLGADEGSLTRPSVWTVAHMAQEVKALDMPAIDFVLSGDEEYWDIQNKLAQPEQLTDSDLAKLHGRFDEIHGYSAPSKAAQLMAGLGFLEHQLRLNVASFSGGWRMRLNLARTLMSRSDLLLLDEPTNHLDLDAILWLEDWLKAYEGTLILISHDRDFLDAITDHILHIENQELTLYTGNYSTFETTRSERLAQQQQAFEKQQEARAHLQKFIDRFKAKATKARQAQSRIKQLERMQQLAPAHVDTPFTFSFREPTKMSSPLLTLENASIGYGDKKIAEKIKLQITPNSRIGLLGMNGAGKSTLIKSLVGDLPLLAGERKASELLNIGYFAQHQMDALDGQASPMLQLARIADKQISEATLRSFLGSFGFSGERMDTPCESFSGGERARLALALIVWQRPNVLILDEPTNHLDLDMRHALSMALQDFEGAVVLVSHERQLIASVCDELLLVHGGKCTEFEGDLQDYAKWLREARQQQINAQTAVAQNNSSSAAPAPAKVDKEAQRKEAARRREQTRPIRKNIEKVESQIEKLQPRLAEIEEALADTSLYEANRKDDLLKLMNEQTELKAKLEQYEEQLLELMMELEEMEASFEN
Atome Classification :
(20 SA)
----------------------------------------------------------------------.........10.....------....20...-.------....30........40........50........60.-.----------.--.---------------....70...--..--...80....-...--.90..-......100--..---.------..-------.-------..110---.......120.......130.......140..-----.....150.......160.......170.......180--.........190--..----..---...200........210.......220.......230.......240.......250..--.....260.--------..-....270..-.....280.----------------------.-.....290...----......300.......------310........320-..--......330-.......-----.340.......350.-----------------......--------360....-----------...370..--.--....380--......----------.------390.---------------------------------------------------------..------------------.-...----------------------------------------------..400---------..---.---------------------------.---------------------------.....410-.......---420-.......---------------430.......440.......450.......460.......470....----...----480.......490.......500--.....-..510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------------------------MIQF
D
Q
V
S
L
R-RG
G
R
V
------
L
F
Q
KAS
M
Q
L-H------PG
W
K
I
G
L
TGVNGA
G
K
S
T
L
F
A
A
L
L
G
SLGADEGSLTRP
S
-
V
----------
W
--
T
---------------
V
A
H
M
A
Q
E
V
K
--AL--DMP
A
I
D
F
V
L-SGD--
E
E
Y
W
D
-
I
Q
N
KLAQP---EQ---L------
T
D
-------
S
-------
D
L
A
K
L
---HG
R
F
D
E
IHGYSA
P
S
K
A
A
Q
L
M
A
G
L
G
F
L
E
H
Q
L
R
L
-----
N
V
ASFSG
G
W
R
M
R
L
N
L
A
R
T
L
MSRS
D
L
L
L
LDEPTNHLD----
L
D
A
I
L
W
L
E
D
W
L
K
--AY----E
G
---
T
L
I
L
I
-SHD
R
D
F
L
D
A
I
T
D
H
I
L
H
IEN
Q
E
L
T
L
Y
TGNYS
T
F
E
T
T
R
S
E
R
L
A
Q
Q
Q
Q
A
F
E
K
Q
Q
E
A
--
R
A
H
L
Q
K
F
I
D
--------
R
F
-
K
A
K
A
T
K
A
R
Q
-
A
Q
S
R
I
K
Q
L
E
----------------------
R
-
M
Q
Q
LAP--AHV----DT
P
F
T
F
SFREPTKMSS------
P
-
L
L
T
L
ENASIGY--G
D
--
K
K
I
A
E
K
I
K
--
L
Q
ITPN
S
-----
R
I
G
L
L
GMNGA
G
K
S
T
L
-----------------
I
K
S
L
V
G--------DLPLLAG-----------
E
R
K
A
S
E
L
L
--
N
--
I
G
Y
F
A
Q
H
--
Q
M
D
ALD----------G------Q--A---------------------------------------------------------
S
P
------------------
M
-
L
Q
L
----------------------------------------------
A
R
I
-----------
A
D
---
K
---------------------------
Q
---------------------------
I
S
E
A
T
L
R
S
-
F
L
G
SFGF---SGE-RMDTPCE---------------SFSGGE
R
A
R
L
A
L
A
L
I
V
WQRP
N
V
L
I
LDEPTNHL
D
L
D
M
R
H
A
L
S
M
A
L
Q
DF----E
G
A
----
V
V
L
VSH
E
R
Q
L
I
A
S
V
C
D
E
L
L
L
VHG--GKCT
E
-
F
EG
D
L
Q
D
Y
A
K
W
L
R
E
A
R
Q
Q
QINA
Q
T
A
V
AQNNSSSAAPAPAKV
D
K
E
A
Q
R
K
E
A
A
R
R
R
E
QT
R
P
I
R
K
N
I
E
K
V
E
S
Q
I
E
K
L
Q
P
R
L
A
E
I
E
E
A
L
ADTSLYEAN
R
K
D
D
L
L
K
L
M
N
E
Q
T
E
L
K
A
K
L
E
Q
Y
E
E
Q
L
L
E
L
M
M
E
L
E
E
M
E
A
SFEN
41
HHSearch
81.12
31%
-2
- C1 -
-
2IW3
1
EF3A_YEAST
A:
[442-978]
-----------------------------------------------------------------------------
S
L
A
-
Y
G
A
K
I
------
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
D
--
G
F
P
T
Q
E
E
-
C
----------
R
--
T
---------------
V
-
Y
V
E
H
D
I
D
GT
H
S
--
D
T
S
V
L
D
F
V
F
-
E
S
G
--
V
---------------------------------------------------------------
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
-----
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
----
T
V
N
V
A
W
L
V
N
Y
L
N
--
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
--------------------
K
A
Y
E
E
--------
L
S
-
N
------------------------------------------
T
---
D
L
--
E
F
K
----
F
P
E
P
G
-
Y
L
E
G
V
K
T
K
Q
K
------
A
-
I
V
K
V
T
N
M
E
F
Q
Y
--
P
G
TS
K
P
Q
I
T
D
I
N
--
F
Q
C
S
L
S
S
-----
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
-----------------
I
N
V
L
T
G
--------
E
L
L
P
T
S
G
-----------
E
V
Y
T
H
E
N
C
--
R
--
I
A
Y
I
K
Q
H
--
A
F
A
H
I
E
SHLDKT
P
S
E
Y
I
------
Q
--
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
------------------
L
G
E
N
I
----------------------------------------------
G
M
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
-
P
---------------------------
R
GELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQFRP
L
T
R
K
E
I
E
E
-
H
C
S
M
L
G
L
---
D
P
E
I
V
S
H
S
R
I
R
---------------
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
D
--
G
R
M
T
P
-----------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
74.08
31%
-12
- C1 -
-
2IX8
-
A:
[1434-1972]
---------------------------------------------------------------------------
E
F
S
L
A
-
Y
G
A
K
I
------
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
D
--
G
F
P
T
Q
E
E
-
C
----------
R
--
T
---------------
V
Y
V
E
H
D
I
D
G
T
-
H
S
--
D
T
S
V
L
D
F
V
F
-
E
S
G
--
V
---------------------------------------------------------------
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
-----
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
----
T
V
N
V
A
W
L
V
N
Y
L
N
--
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
-----
A
---------
Y
---
E
E
L
S
N
--------
T
--
D
------------------------------------------
L
E
------
F
K
F
----
P
-
E
P
G
-
Y
L
E
G
V
K
T
K
Q
K
------
A
-
I
V
K
V
T
N
M
E
F
Q
Y
--
P
G
TS
K
P
Q
I
T
D
I
N
--
F
Q
C
S
L
S
S
-----
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
-----------------
I
N
V
L
T
G
--------
E
L
L
P
T
S
G
-----------
E
V
Y
T
H
E
N
C
--
R
--
I
A
Y
I
K
Q
H
--
A
F
A
H
I
E
SHLDKT----
P
S
E
Y
I
--
Q
W
R
F
Q
TG-------------------------------------------------------
D
RETMDRANRQINENDAEA
M
-
N
K
I
F
K
I
E
G
T
P
R
R
I
AGI
H
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
NIGMKSE
R
W
V
P
M
M
S
V
D
-----------
N
A
W
I
-
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
ALASGQFR
P
---------------------------
L
T
R
K
E
I
E
E
-
H
C
S
M
L
G
L
---
D
P
E
I
V
S
H
S
R
I
R
---------------
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
D
--
G
R
M
T
P
-----------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.35
31%
2
- C1 -
-
4FIN
6
ETTA_ECOLI
A:
[19-533]
------------------------------------------------------------------------------------
R
H
------
I
L
K
N
I
S
L
S
F
-
F
------
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
G
E
A
R
P
Q
P
-
D
----------
I
--
K
---------------
I
G
Y
L
P
Q
E
P
Q
--
L
----
N
P
E
H
T
V
R
E
-
S
I
E
--
E
A
V
S
E
-
V
V
N
A
L
K
R
L
---
D
E
---
V
Y
A
L
YAD
P
D
-------
A
-------
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
---
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
PDWDA
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
----
A
E
S
V
A
W
L
E
R
F
L
H
--
D
F
----
E
G
---
T
V
V
A
I
-
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
-----
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
--------
W
V
-
R
-
Q
G
T
K
-----
K
G
K
A
R
-
L
A
----------------------
R
-
F
E
E
L
N
S
--
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
-
R
L
G
D
------
K
-
V
L
E
V
S
N
L
R
K
S
Y
--
G
D
--
R
L
L
I
D
D
L
S
--
F
S
I
P
K
G
A
-----
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
-----------------
F
R
M
I
S
G
--------
Q
E
Q
P
D
S
G
-----------
T
I
T
L
G
E
T
V
--
K
--
L
A
S
V
D
Q
F
--
R
-
D
S
M
D
----------
N
SKT
V
W
E
E
--
V
---------------------------------------------------------
S
G
------------------
G
-
L
D
I
----------------------------------------------
M
K
I
-----------
G
N
------------------------------------------------------------
T
E
M
P
S
R
A
-
Y
V
G
R
F
N
F
---
K
G
V
-
D
Q
G
K
R
V
G
---------------
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E-
G
K
V
E
F
-
F
E
G
N
F
T
E
Y
E
E
Y
-----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.13
31%
34
- C1 -
-
3J5S
-
ETTA_ECOLI
D:
[2-533]
-----------------------------------------------------------------------
A
Q
F
-
V
Y
T
M
H
-
R
V
G
K
V
VPPKRH
I
L
K
N
I
S
L
S
F
-
F
------
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
G
E
A
R
P
Q
P
-
D
----------
I
--
K
---------------
I
G
Y
L
P
Q
E
P
Q
--
L
----
N
P
E
H
T
V
R
E
-
S
I
E
--
E
A
V
S
E
-
V
V
N
A
L
K
R
L
---
D
E
---
V
YALYAD
P
D
-------
A
-------
D
F
D
K
L
AAE
Q
G
R
L
E
E
I
---
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
PDWDA
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
----
A
E
S
V
A
W
L
E
R
F
L
H
--
D
F
----
E
G
---
T
V
V
A
I
-
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
-----
E
A
S
Q
E
A
AR
R
K
S
I
E
K
E
L
E
--------
W
V
-
R
-
Q
G
T
K
G
R
Q
-
S
K
G
K
A
R
-
L
A
----------------------
R
-
F
E
E
L
N
S
--
T
E
Y
QKRN
E
T
N
E
L
F
I
P
P
G
P
-
R
L
G
D
------
K
-
V
L
E
V
S
N
L
R
K
S
Y
--
G
D
--
R
L
L
I
D
D
L
S
--
F
S
I
P
K
G
A
-----
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
-----------------
F
R
M
I
S
G
--------
Q
E
Q
P
D
S
G
-----------
T
I
T
L
G
E
T
V
--
K
--
L
A
S
V
D
Q
F
--
R
-
D
S
M
D
----------
N
SKTVWE
E
--
V
---------------------------------------------------------
S
G
------------------
G
-
L
D
I
----------------------------------------------
M
K
I
-----------
G
N
------------------------------------------------------------
T
E
M
P
S
R
A
-
Y
V
G
R
F
N
F
---
K
G
V
-
D
Q
G
K
R
V
G
---------------
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E-
G
K
V
E
F
-
F
E
G
N
F
T
E
Y
E
E
Y
-----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.61
26%
-5
- C1 -
-
2IWH
1
EF3A_YEAST
A:
[440-977]
---------------------------------------------------------------------------
E
F
S
L
A
-
Y
G
A
K
I
------
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
--
G
Q
V
D
G
F
P
T
Q
E
E
-
C
----------
R
--
T
---------------
V
-
Y
V
E
H
D
I
D
--
G
T
HS
D
T
S
V
L
D
F
V
F
E
S
G
V
--
G
T
K
E
A
-
I
K
D
K
L
I
E
---------------------------------------------------------------
F
G
F
T
D
E
M
I
A
M
-----
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
----
T
V
N
V
A
W
L
V
N
Y
L
N
--
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
-----
T
E
F
V
K
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
--
D
L
E
F
-
K
F
P
E
--------
P
G
-
Y
L
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
PGTSKPQITD
I
N
F
Q
C
S
LSS
R
-
I
A
V
I
G
P
NG
A
G
K
----
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
------
E
-
V
Y
T
H
E
N
C
R
I
A
Y
--
I
K
--
Q
H
A
F
A
H
I
E
SH
L
D
K
T
P
S
E
-----
Y
I
Q
W
R
F
Q
T
G
E
D
R
E
T
M
DRANRQINEND
A
E
A
M
N
K
I
F
K
I
E
G
--------
T
P
R
R
I
A
G
I
H
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
--
I
G
M
K
S
E
R
W
V
P
M
M
S
V
D
----------
N
------
A
--
W
---------------------------------------------------------
I
P
------------------
R
-
G
E
L
----------------------------------------------
V
E
S
-----------
H
S
---
K
---------------------------
M
---------------------------
V
A
E
V
D
M
K
E
-
A
L
A
S
G
Q
F
RPL
T
R
K
-
E
I
E
E
H
C
S
M
L
GLD
P
E
I
V
S
HSRIR
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
D
--
G
R
M
T
------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.90
26%
-3
- C1 -
-
2IX3
-
EF3A_YEAST
A:
[440-977]
---------------------------------------------------------------------------
E
F
S
L
A
-
Y
G
A
K
I
------
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
--
G
Q
V
D
G
F
P
T
Q
E
E
-
C
----------
R
--
T
---------------
V
-
Y
V
E
H
D
I
D
--
G
T
HS
D
T
S
V
L
D
F
V
F
E
S
G
V
--
G
T
K
E
A
-
I
K
D
K
L
I
E
---------------------------------------------------------------
F
G
F
T
D
E
M
I
A
M
-----
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
----
T
V
N
V
A
W
L
V
N
Y
L
N
--
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
-----
T
E
F
V
K
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
--
D
L
E
F
-
K
F
P
E
--------
P
G
-
Y
L
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
PGTSKPQITD
I
N
F
Q
C
S
LSS
R
-
I
A
V
I
G
P
NG
A
G
K
----
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
------
E
-
V
Y
T
H
E
N
C
R
I
A
Y
--
I
K
--
Q
H
A
F
A
H
I
E
SH
L
D
K
T
P
S
E
-----
Y
I
Q
W
R
F
Q
T
G
E
D
R
E
T
M
DRANRQINENDAEAMN
K
I
F
K
I
E
G
--------
T
P
R
R
I
A
G
IH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
--
I
G
M
K
S
E
R
W
V
P
M
M
S
V
D
----------
N
------
A
--
W
---------------------------------------------------------
I
P
------------------
R
-
G
E
L
----------------------------------------------
V
E
S
-----------
H
S
---
K
---------------------------
M
---------------------------
V
A
E
V
D
M
K
E
-
A
L
A
S
G
Q
F
RPL
T
R
K
-
E
I
E
E
H
C
S
M
L
GLD
P
E
I
V
S
HSRIR
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
D
--
G
R
M
T
------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
63.77
27%
36
- C1 -
-
3J5S
-
ETTA_ECOLI
D:
[9-533]
--------------------------------------------------------------------------
H
R
V
G
K
V
V
P
P
K
R
H
------
I
L
K
N
I
S
L
S
F
-
F
------
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
G
E
A
R
P
Q
P
-
D
----------
I
--
K
---------------
I
G
Y
L
P
Q
E
P
Q
L-
N
P
--
E
H
T
V
R
E
S
I
E
-
E
A
V
--
S
E
V
V
N
-
A
L
K
R
L
D
E
V
---
Y
A
LYA
D
------
P
D
-------
A
DFDKLAA
E
Q
G
R
L
---
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
--
D
W
D
A
-----
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
----
A
E
S
V
A
W
L
E
R
F
L
H
--
D
F
----
E
G
---
T
V
V
A
I
-
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
--
I
E
K
E
L
E
W
V
R
--------
Q
G
-
T
-
K
G
-
R
Q
S
K
-
G
K
A
R
L
A
R
F
E
----------------------
E
-
L
N
S
T
E
Y
--
Q
K
R
----
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
------
K
-
V
L
E
V
S
N
L
R
K
S
Y
--
G
D
--
R
L
L
I
D
D
L
S
--
F
S
I
P
K
G
A
-----
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
-----------------
F
R
M
I
S
G
--------
Q
E
Q
P
D
S
G
-----------
T
I
T
L
G
E
T
V
--
K
--
L
A
S
V
D
Q
F
--
R
D
-
S
M
D
----------
N
------
S
--
K
---------------------------------------------------------
T
V
------------------
W
-
E
E
V
----------------------------------------------
S
G
G
-----------
L
D
IMK
I
---------------------------
G
---------------------------
N
T
E
M
P
S
R
A
-
Y
V
G
R
F
N
F
---
K
G
V
-
D
Q
G
K
R
V
G
---------------
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
--
E
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
-----------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.23
23%
18
- C1 -
-
3J15
2
?
B:
[78-533]
------------------------------------------------------------------------
Q
L
D
E
D
C
V
H
-
R
Y
G
V
N
------
A
F
V
L
Y
R
L
P
I
V
K
------
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
------------------------------------------
I
P
N
L
C
E
D
N
D
--
S
W
--
D
N
V
I
R
A
F
R
G
-
N
E
L
--
Q
N
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
K
P
Q
---
Y
------
V
D
L
L
P
K
A
V
K
G
-------
K
V
R
E
L
---
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
------------
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
----
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
----
E
G
---
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
-
V
I
H
V
V
Y
G
E
P
G
V
Y
G
-------------------
I
F
S
K
P
K
G
T
--
R
N
G
I
N
E
F
L
Q
--------
G
Y
L
K
D
E
N
V
R
F
R
P
-
Y
E
I
R
F
T
K
L
S
----------------------
E
----------
R
V
----
D
V
E
-----
R
E
-
T
L
V
E
Y
------
P
-
R
L
V
K
D
Y
G
S
F
---------------
K
--
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
-----------------
V
K
M
L
A
G
V-------
E
E
P
T
--------------
E
G
K
V
E
W
D
L
--
T
--
V
A
Y
K
P
Q
Y
--
I
K
A
E
Y
E
----------
G
------
T
--
V
---------------------------------------------------------
Y
E
------------------
L
-
L
------------------------------------------------
S
K
I
-----------
D
S
---
S
---------------------------
K
---------------------------
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
---
I
-
D
-
L
Y
D
R
N
V
E
---------------
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.03
23%
13
- C1 -
-
3BK7
2
?
A:
[92-547]
------------------------------------------------------------------------
Q
L
D
E
D
C
V
H
-
R
Y
G
V
N
------
A
F
V
L
Y
R
L
P
I
V
K
------
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
------------------------------------------
I
P
N
L
C
E
D
N
D
--
S
W
--
D
N
V
I
R
A
F
R
G
-
N
E
L
--
Q
N
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
K
P
Q
---
Y
------
V
D
L
L
P
K
A
V
K
G
-------
K
V
R
E
L
---
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
------------
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
----
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
----
E
G
---
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
-
V
I
H
V
V
Y
G
E
P
G
V
Y
G
-------------------
I
F
S
K
P
K
G
T
--
R
N
G
I
N
E
F
L
Q
--------
G
Y
L
K
D
E
N
V
R
F
R
P
-
Y
E
I
R
F
T
K
L
S
----------------------
E
----------
R
V
----
D
V
E
-----
R
E
-
T
L
V
E
Y
------
P
-
R
L
V
K
D
Y
G
S
F
---------------
K
--
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
-----------------
V
K
M
L
A
G
V-------
E
E
P
T
--------------
E
G
K
V
E
W
D
L
--
T
--
V
A
Y
K
P
Q
Y
--
I
K
A
E
Y
E
----------
G
------
T
--
V
---------------------------------------------------------
Y
E
------------------
L
-
L
------------------------------------------------
S
K
I
-----------
D
S
---
S
---------------------------
K
---------------------------
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
---
I
-
D
-
L
Y
D
R
N
V
E
---------------
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.36
23%
19
- C1 -
-
5LW7
-
?
B:
[78-533]
------------------------------------------------------------------------
Q
L
D
E
D
C
V
H
-
R
Y
G
V
N
------
A
F
V
L
Y
R
L
P
I
V
K
------
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
------------------------------------------
I
P
N
L
C
E
D
N
D
--
S
W
--
D
N
V
I
R
A
F
R
G
-
N
E
L
--
Q
N
Y
F
E
R
L
K
N
G
E
I
R
P
VVK
P
Q
---
Y
------
V
D
LLPKAVK
G
-------
K
V
R
E
L
---
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
------------
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
----
I
R
Q
R
L
K
V
A
R
V
I
R
RL
A
N
----
E
G
---
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
-
V
I
H
V
V
Y
G
E
P
G
V
Y
G
-------------------
I
F
S
K
P
K
G
T
--
R
N
G
I
N
E
F
L
Q
--------
G
Y
L
K
D
E
N
V
R
F
R
P
-
Y
E
I
R
F
T
K
L
S
----------------------
E
----------
R
V
----
D
V
E
-----
R
E
-
T
L
V
E
Y
------
P
-
R
L
V
K
D
Y
G
S
F
---------------
K
--
L
E
V
E
P
G
E
IRKGE
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
-----------------
V
K
M
L
A
G
V-------
E
E
P
T
--------------
E
G
K
V
E
W
D
L
--
T
--
V
A
Y
K
P
Q
Y
--
I
K
A
E
Y
E
----------
G
------
T
--
V
---------------------------------------------------------
Y
E
------------------
L
-
L
------------------------------------------------
S
K
I
-----------
D
S
---
S
---------------------------
K
---------------------------
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
---
I
-
D
-
L
Y
D
R
N
V
E
---------------
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
MEKN
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
58.71
22%
5
- C1 -
-
1YQT
2
?
A:
[25-481]
--------------------------------------------------------------------------
E
D
C
V
H
R
-
Y
G
V
N
A
------
F
V
L
Y
R
L
P
V
V
-
K
------
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
G
D
N
D
S
W
D
G
----------
V
--
I
---------------
R
A
F
R
G
N
E
L
Q
--------
N
Y
F
E
K
L
K
-
N
G
E
--
I
R
P
V
--
V
K
P
Q
Y
V
D
L
---
I
P
---
K
---------------
A
-------
V
K
G
K
V
---
I
E
L
L
---
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
-
N
V
L
E
R
-----
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
----
I
R
Q
R
L
N
A
A
R
A
I
R
--
R
L
S
E
E
-
G
K
---
S
V
L
V
V
-
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
-
H
V
V
Y
G
E
P
G
V
Y
-
G
I
F
S
---
Q
P
K
G
T
R
N
-----
G
I
N
E
---
F
--
L
--
R
G
Y
L
K
D
--------
E
N
-
V
----
R
F
----
R
P
Y
E
I
K
F
T
----------------------
K
-
T
G
E
--------------
R
V
E
-------
I
E
R
E
------
T
-
L
V
T
Y
P
R
L
V
K
D
Y
--
G
---
S
F
R
L
E
V
E
P
--
G
E
I
K
K
G
E
-----
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
-----------------
V
K
M
L
A
G
--------
V
E
E
P
T
E
G
-----------
K
I
E
W
D
L
----
T
--
V
A
Y
K
P
Q
Y
--
I
K
--
A
D
----------
Y
------
E
--
G
---------------------------------------------------------
T
V
------------------
Y
-
E
L
L
----------------------------------------------
S
K
I
-----------
D
A
---
S
K
--------------------------
L
---------------------------
N
S
N
F
Y
K
T
E
-
L
L
K
P
L
G
I
---
I
D
--
L
Y
D
R
E
V
N
---------------
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
--
E
P
G
K
------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.63
28%
-13
- C1 -
-
2IW3
1
EF3A_YEAST
A:
[440-744]
---------------------------------------------------------------------------
E
F
S
L
A
-
Y
G
A
K
I
------
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
--
G
Q
V
D
G
F
P
T
Q
E
E
-
C
----------
R
--
T
---------------
V
-
Y
V
E
H
D
I
D
--
G
T
HS
D
T
S
V
L
D
F
V
F
E
S
G
V
--
G
T
K
E
A
-
I
K
D
K
L
I
E
---------------------------------------------------------------
F
G
F
T
D
E
M
I
A
M
-----
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
----
T
V
N
V
A
W
L
V
N
Y
L
N
--
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
-----------------------------------------
K
C
P
A
A
K
A
Y
E
-
E
L
S
---------------------------------------------
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
G
VKTKQK
A
-
I
V
K
V
T
N
M
E
F
Q
Y
PG
T
S
--
K
P
Q
I
T
D
I
N
--
F
Q
C
S
L
S
S
-----
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
-----------------
I
N
V
L
T
G
--------
E
L
L
P
T
S
G
-----------
E
V
Y
T
H
E
N
C
--
R
--
I
A
Y
I
K
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
57.47
19%
-0
- C1 -
-
4CRM
2
RLI1_YEAST
P:
[99-559]
---------------------------------------------------------------------------------------------------
T
P
-
R
------
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
G
R
F
D
D
P
P
-
E
----------
W
QE
I
---------------
I
K
Y
F
R
G
S
E
L
QN
Y
F
--
T
K
M
L
E
D
D
I
K
-
A
I
I
--
K
-
P
-
Q
-
Y
V
D
N
I
P
R
A
---
I
------------
K
-------
G
-------
P
V
Q
K
V
---
G
E
L
L
-
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
-
N
V
L
K
R
-----
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
----
V
K
Q
R
L
N
A
A
Q
I
I
R
--
S
L
LAP-
T
K
---
Y
V
I
C
V
-
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
G
V
V
T
L
P
A
S
V
R
---
E
G
I
-------------------
N
I
F
L
D
--------
G
H
-
I
----
P
A
E
N
-
L
R
F
R
T
E
A
L
Q
----------------------
F
R
I
A
D
-----
A
--------
T
E
--
D
L
--
Q
N
D
S
A
S
------
R
-
A
F
S
Y
P
S
L
K
K
T
Q
---
G
--
D
F
V
L
N
V
E
E
--
G
E
F
S
D
S
E
-----
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
-----------------
I
K
L
L
A
G
--------
A
L
K
P
D
E
G
-----------
Q
D
I
P
K
--
L
--
N
--
V
S
M
K
P
Q
K
--
I
A
--
P
K
----------
F
------
P
--
G
---------------------------------------------------------
T
V
------------------
R
-
Q
L
F
----------------------------------------------
F
K
K
-----------
I
R
G--
Q
---------------------------
F
---------------------------
L
N
P
Q
F
Q
T
D
-
V
V
K
P
L
R
I
---
D
D
--
I
I
D
Q
E
V
Q
---------------
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
ILHN
K
K
T
----
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
IP
S
K
N
A
--
H
A
R
A
P
E
S
L
L
T
------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.07
23%
5
- C1 -
-
1YQT
2
?
A:
[47-486]
--------------------------------------------------------------------------------------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
------------------------------------------
I
P
N
L
C
G
D
N
D
--
S
W
--
D
G
V
I
R
A
F
R
G
-
N
E
L
--
Q
N
Y
F
E
K
L
K
N
G
E
I
R
P
V
V
K
P
Q
---
Y
------
V
D
-------
L
-------
I
P
K
A
V
---
K
G
K
V
I
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
V
L
E
R
-----
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
----
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
----
E
G
K
--
S
V
L
V
V
-
E
H
D
L
A
V
L
D
Y
L
S
D
-
I
I
H
V
V
Y
G
E
----
P
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
E
F
L
---------
R
G
Y
L
K
D
E
N
V
--------
R
F
-
R
P
Y
E
I
K
F
T
K
-
T
G
E
R
V
-
E
I
E
----------------------
R
--------------------------
E
T
L
V
T
Y
------
P
-
R
L
V
K
D
Y
G
S
F
---------------
R
--
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
-----------------
V
K
M
L
A
G
V-------
E
E
P
T
--------------
E
G
K
I
E
W
D
L
--
T
--
V
A
Y
K
P
Q
Y
--
I
K
A
D
Y
E
----------
G
------
T
--
V
---------------------------------------------------------
Y
E
------------------
L
-
L
------------------------------------------------
S
K
I
D----------
A
S
---
K
---------------------------
L
---------------------------
N
S
N
F
Y
K
T
E
-
L
L
K
P
L
G
I
---
I
-
D
-
L
Y
D
R
E
V
N
---------------
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
-----------
F
E
G
E
P
G
K
Y
G
R
A
L
----------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.57
28%
-14
- C1 -
-
2IX8
-
A:
[1434-1739]
---------------------------------------------------------------------------
E
F
S
L
A
-
Y
G
A
K
I
------
L
L
N
K
T
Q
L
R
L
-
K
------
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
--
G
Q
V
D
G
F
P
T
Q
E
E
-
C
----------
R
--
T
---------------
V
-
Y
V
E
H
D
I
D
--
G
T
H
S
D
T
S
V
L
D
F
V
F
E
S
G
V
--
G
T
K
E
A
-
I
K
D
K
L
I
E
---------------------------------------------------------------
F
G
F
T
D
E
M
I
A
M
-----
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
----
T
V
N
V
A
W
L
V
N
Y
L
N
--
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
-----------------------------------------
K
C
P
A
A
K
A
Y
E
-
E
L
S
---------------------------------------------
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
G
VKTKQK
A
-
I
V
K
V
T
N
M
E
F
Q
Y
PG
T
S
--
K
P
Q
I
T
D
I
N
--
F
Q
C
S
L
S
S
-----
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
-----------------
I
N
V
L
T
G
--------
E
L
L
P
T
S
G
-----------
E
V
Y
T
H
E
N
C
--
R
--
I
A
Y
I
K
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
55.38
20%
40
- C1 -
-
3J16
3
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CPFDA
I
Q
I
I
N
L
P
T
N
L
E
-
A
H
V
T
H
------
R
Y
S
A
N
S
F
K
L
-
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
G
R
F
D
D
P
P
-
E
----------
W
--
Q
---------------
E
I
I
K
Y
F
R
G
S
--
E
L
--
Q
N
Y
F
T
K
M
L
E
-
D
D
I
K
A
I
I
K
P
Q
-
Y
V
D
N
I
P
R
A
---
I
K
---
G
------
P
V
-------
Q
-------
K
V
G
E
L
---
L
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
-----
L
E
N
V
L
K
R
-----
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
----
V
K
Q
R
L
N
A
A
Q
I
I
R
--
S
L
----
L
A
P
T
K
Y
V
I
C
V
-
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
-----
S
V
Y
G
V
V
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
---------
G
H
I
P
A
E
N
L
--------
R
F
-
R
T
E
A
L
Q
F
R
I
-
A
D
A
T
E
D
L
---------------------------------------------------
Q
N
D
S
A
S
------
R
-
A
F
S
Y
P
S
L
K
K
T
Q
--
G
D
--
F
V
L
N
V
E
-
E
--
G
E
F
S
D
S
E
-----
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
-----------------
I
K
L
L
A
G
--------
A
L
K
P
D
E
G
-----------
Q
D
I
P
K
--
L
--
N
--
V
S
M
K
P
Q
K
--
I
A
P
K
F
P
----------
G
------
T
--
V
---------------------------------------------------------
R
Q
------------------
L
-
F
F
K
----------------------------------------------
K
-
I
-----------
R
G
---
Q
---------------------------
F
---------------------------
L
N
P
Q
F
Q
T
D
-
V
V
K
P
L
R
I
---
D
-
D
-
I
I
D
Q
E
V
Q
---------------
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
----
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
-----------------------------------
I
P
S
K
N
A
H
A
R
A
P
-----------------------------
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
R
D
P
N
S
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
N
T
G
I
---------------
12
PsiBlast_PDB
53.37
21%
4
- C1 -
-
4CRM
2
RLI1_YEAST
P:
[87-543]
---------------------------------------------------------------------------------------------
Y
S
A
N
S
F
K
L
-
H
RLPTPR
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
G
R
F
D
D
P
P
-
E
----------
W
--
Q
EIIKYFRGSELQNYF
T
K
M
L
E
D
D
I
K
--
A
I
--
I
K
P
-------------
Q
Y
V
D
N
I
P
R
A
I
K
G
P
---
V
Q
---
K
------
V
-------------------------
G
E
L
L
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
-
L
E
N
V
L
K
R
-----
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
VKQR
L
N
A
A
Q
I
I
R
S
L
L
---
A
P
----
T
K
---
Y
V
I
C
V
-
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
--------
C
I
I
Y
G
V
P
S
V
Y
G
V
V
T
L
P
------------
A
S
V
--
R
E
G
I
N
I
F
L
D
GHIPAENL
R
F
-
R
T
E
A
L
Q
F
R
I
-
A
D
A
T
----
E
----------------------
D
-
L
Q
N
D
S
A
--
S
R
---------
A
F
S
Y
P
S
L
K
K
T
Q
G
------
D
F
V
L
N
V
E
E
G
E
--
F
--
S
D
--
S
E
I
--------------------
L
V
M
M
G
E
N
G
T
G
K
T
T
L
-----------------
I
K
L
L
A
G
ALKPDEGQ
D
I
P
K
L
N
V
-----------
S
M
K
P
Q
K
I
A
--
P
KF
P
G
T
V
R
Q
L
--
F
F
K
K
I
R
----------
G
------
Q
F-
L
---------------------------------------------------------
N
P
------------------
Q
-
F
Q
T
----------------------------------------------
D
V
V
-----------
K
P
---
L
---------------------------
R
---------------------------
I
D
D
I
--------------------
I
D
Q
E
V
Q
---------------
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
ILHN
K
K
T
----
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
53.07
21%
4
- C1 -
-
3J16
1
RLI1_YEAST
B:
[87-543]
---------------------------------------------------------------------------------------------
Y
S
A
N
S
F
K
L
-
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
G
R
F
D
D
P
P
-
E
----------
W
--
Q
E
I
I
K
Y
F
RGSEL
Q
N
Y
F
T
K
M
L
E
D
D
I
K
--
A
I
--
I
K
P
-------------
Q
Y
V
D
N
I
P
R
A
I
K
G
P
---
V
Q
---
K
------
V
-------------------------
G
E
L
L
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
-
L
E
N
V
L
K
R
-----
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
---
A
P
----
T
K
---
Y
V
I
C
V
-
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
--------
C
I
I
Y
G
V
P
S
V
Y
G
V
V
T
L
P
------------
A
S
V
--
R
E
G
I
N
I
F
L
D
GHIPAENL
R
F
-
R
T
E
A
L
Q
F
R
I
-
A
D
A
T
----
E
----------------------
D
-
L
Q
N
D
S
A
--
S
R
---------
A
F
S
Y
P
S
L
K
K
T
Q
G
------
D
F
V
L
N
V
E
E
G
E
--
F
--
S
D
--
S
E
I
--------------------
L
V
M
M
G
E
N
G
T
G
K
T
T
L
-----------------
I
K
L
L
A
G
ALKPD
E
G
Q
D
I
P
K
L
N
V
-----------
S
M
K
P
Q
K
I
A
--
P
KF
P
G
T
V
R
Q
L
--
F
F
K
K
I
R
----------
G
------
Q
F-
L
---------------------------------------------------------
N
P
------------------
Q
-
F
Q
T
----------------------------------------------
D
V
V
-----------
K
P
---
L
---------------------------
R
---------------------------
I
D
D
I
--------------------
I
D
Q
E
V
Q
---------------
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
----
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
52.59
23%
-43
- C1 -
-
4YER
2
?
A:
[5-251]
----------------------------------------------------------------------
I
I
V
V
E
N
L
V
K
K
-
F
G
D
F
E
------
A
V
K
G
V
S
F
S
V
-
K
------
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
-
H
DVLKE
P
R
E
V
R
R
--
K
---------------
I
G
I
V
F
Q
D
Q
S
L-
D
R
--
E
L
T
A
Y
E
N
M
Y
-
I
H
G
--
K
I
Y
G
--------------------------------------------------------
Y
G
G
E
K
L
K
K
R
I
L
E
L
L
E
F
V
E
L
L
E
-
F
K
D
K
-----
P
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
----
P
H
T
R
A
H
M
W
E
Y
I
S
--
K
M
K
K
EH
N
M
---
T
I
F
L
T
-
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
L
-
G
T
P
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
51.14
22%
-60
* C1 *
-
3RLF
2
MALK_ECOLI
A:
[3-215]
----------------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
A
-
W
G
E
V
V
------
V
S
K
D
I
N
L
D
I
-
H
------
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
RMNDTPPAE-
R
--
G
---------------
V
G
M
V
F
Q
S
Y
A
L-
Y
P
--
H
L
S
V
A
E
N
M
S
-
F
G
L
--
K
L
A
G
--------------------------------------------------------
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
-----
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
----
A
A
L
R
V
Q
M
R
I
E
I
S
--
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
-
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------